DNMT1 Cancer Research Results

DNMT1, DNA (cytosine-5-)-methyltransferase 1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
DNMT1 overexpression in various cancer types.
DNA (cytosine-5-)-methyltransferase 1, commonly referred to as DNMT1, is an enzyme that plays a crucial role in the maintenance of DNA methylation patterns.
Increased DNMT1 activity can promote tumorigenesis by facilitating the accumulation of methylation changes that drive cancer progression.
Is frequently overexpressed in a variety of cancers, including breast, colorectal, lung, prostate, and hematological malignancies. This overexpression is often associated with hypermethylation of tumor suppressor genes, leading to their silencing and contributing to tumorigenesis.
Scientific Papers found: Click to Expand⟱
3424- TQ,    Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex
- Review, Var, NA
DNMT1↓, HDAC1↓, TumCCA↑, ROS↑, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, BioAv↓, BioAv↓, HDAC1↓, HDAC4↓, UHRF1↓, selectivity↑, G9a↓,

Showing Research Papers: 51 to 51 of 51
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 51

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx4↓, 1,   GSH↓, 3,   GSS↑, 1,   HO-1↑, 3,   lipid-P↑, 1,   MDA↓, 1,   NQO1↑, 3,   NRF2↓, 2,   NRF2↑, 5,   ROS↓, 1,   ROS↑, 15,   ROS⇅, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   AMACR↓, 1,   AMPK↑, 4,   ATP↓, 1,   Glycolysis↓, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HK2↓, 1,   PDK1 / PDPK1↓, 1,   PKM2↓, 2,   RARβ↑, 1,   SIRT1↓, 2,   SIRT1↑, 2,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 1,   Apoptosis↑, 15,   aSmase↝, 1,   Bak↑, 1,   BAX↑, 12,   Bcl-2↓, 8,   Bcl-xL↓, 3,   BID↓, 1,   BID↑, 1,   BIM↑, 1,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 3,   Casp3↑, 11,   cl‑Casp3↑, 1,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 2,   Casp8↑, 3,   Casp9↑, 7,   cFLIP↓, 1,   CSR1↑, 1,   Cyt‑c↑, 4,   Diablo↑, 1,   DR5↑, 1,   Fas↓, 1,   Fas↑, 1,   Ferroptosis↑, 2,   iNOS↓, 3,   Mcl-1↓, 3,   MDM2↓, 1,   NOXA↑, 1,   p38↑, 1,   RIP1↑, 1,   RIP3↑, 1,   survivin↓, 5,   TRAIL↑, 2,   XIAP↓, 2,   XIAP↝, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9,   Akt↑, 1,   p‑Akt↓, 2,   Akt2↓, 1,   cMET↓, 2,   cSrc↓, 1,   EGFR↓, 2,   p‑EGFR↓, 1,   EphB4↓, 1,   ERK↓, 4,   p‑ERK↓, 1,   FLT4↓, 1,   IGF-1R↓, 1,   IGFR↓, 1,   IκB↓, 1,   IκB↑, 1,   JAK2↓, 5,   JNK↑, 1,   MAPK↓, 6,   MAPK↑, 1,   mTOR↓, 5,   mTORC2↓, 1,   P70S6K↓, 1,   PI3K↓, 9,   p‑PI3K↓, 1,   PTEN↑, 6,   Sp1/3/4↓, 3,   Src↓, 1,   STAT3↓, 7,   STAT3↑, 1,   p‑STAT3↓, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 3,   DNMT1↓, 43,   DNMT1↑, 2,   DNMT3A↓, 14,   DNMT3A↑, 1,   DNMTs↓, 7,   EZH2↓, 4,   FOXO↑, 2,   FOXO3↓, 1,   FOXO3↑, 1,   p‑FOXO3↓, 1,   ac‑H3↑, 3,   ac‑H4↑, 2,   HATs↓, 1,   HATs↑, 1,   HDAC↓, 12,   HDAC↑, 1,   HDAC1↓, 10,   HDAC2↓, 3,   HDAC3↓, 4,   HDAC4↓, 6,   HDAC8↓, 3,   HMTs↑, 1,   miR-148a↑, 1,   miR-155↓, 2,   miR-200c↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   miR-29b↓, 2,   miR-29b↑, 1,   miR-34a↑, 1,   Myc↓, 2,   MYCN↓, 1,   OCT4↓, 2,   other↝, 1,   PRC2↓, 1,   SOX2↓, 2,   SOX9?, 1,   SOX9↓, 1,   SPP1↓, 1,   TET3↑, 1,   tumCV↓, 5,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↓, 1,   ER Stress↑, 2,   Hsc70↓, 1,   HSP90↓, 1,   ac‑HSP90↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↑, 2,   LC3II↓, 1,   LC3II↑, 2,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   BRCA1↑, 2,   DFF45↓, 1,   DFF45↑, 1,   DNA-PK↓, 1,   DNAdam↑, 3,   G9a↓, 3,   hTERT/TERT↓, 5,   p16↑, 3,   P53↑, 7,   PARP↑, 3,   cl‑PARP↑, 4,   PARP1↓, 1,   PCNA↓, 1,   SIRT6↓, 1,   Telomerase↓, 1,   TP53↑, 2,   UHRF1↓, 5,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 2,   CDK2↓, 1,   CDK4↓, 1,   CDK6↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 7,   cycD1/CCND1↑, 1,   E2Fs↓, 1,   Ki-67↓, 1,   P21↓, 1,   P21↑, 7,   p27/CDKN1B↑, 4,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   CD133↓, 2,   CDX2↓, 1,   CSCs↓, 5,   FBXW7↝, 1,   IGFBP1↑, 1,   Ki-67↓, 1,   Nanog↓, 3,   NOTCH↓, 3,   NOTCH1↓, 1,   NOTCH3↓, 1,   Shh↓, 1,   TumCG↓, 6,   TumCP↓, 6,   Wnt↓, 9,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

67LR↓, 1,   AP-1↓, 4,   Ca+2↑, 1,   CCN2/CTGF↓, 1,   CDH1↑, 1,   DLC1↑, 2,   E-cadherin↑, 3,   EMT↓, 8,   FAK↓, 2,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 1,   ITGA6↓, 1,   ITGB3↓, 1,   LAMs↓, 1,   MMP-10↓, 1,   MMP13↓, 1,   MMP2↓, 4,   MMP7↓, 3,   MMP9↓, 6,   MMPs↓, 3,   N-cadherin?, 1,   N-cadherin↓, 3,   NM23↑, 1,   RECK↑, 1,   Slug↓, 1,   Snail↓, 3,   TET1↑, 4,   TGF-β↓, 2,   TumCI↓, 5,   TumCMig↓, 5,   TumMeta↓, 5,   Twist↓, 5,   uPA↓, 1,   Vim↓, 4,   Zeb1↓, 3,   α-SMA↓, 1,   β-catenin/ZEB1↓, 8,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   CCN1/CYR61↓, 1,   ECM/TCF↓, 1,   Hif1a↓, 5,   NO↑, 1,   VEGF↓, 8,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 2,   MPT↑, 1,   NHE1↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   COX2/PTGS2↓, 8,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 3,   IL1↓, 1,   IL10↓, 2,   IL12↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 6,   Inflam↓, 2,   NF-kB↓, 16,   NF-kB↑, 1,   p65↓, 1,   TNF-α↓, 4,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

PLC↓, 1,  

Protein Aggregation(tgid=19) ⓘ

SNCG↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   COMT↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 6,   BioAv↑, 2,   ChemoSen↑, 10,   CompStab↝, 2,   CYP1B1↑, 2,   eff↓, 1,   eff↑, 3,   eff↝, 1,   GSTA1↑, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   RadioS↑, 5,   selectivity↑, 9,   Synergy↑, 9,   TET2↓, 1,   TET2↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   BRCA1↑, 2,   EGFR↓, 2,   p‑EGFR↓, 1,   EZH2↓, 4,   HEC1↓, 1,   hTERT/TERT↓, 5,   IL6↓, 6,   Maspin↑, 1,   Myc↓, 2,   NOS2↓, 2,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   chemoPv↑, 2,   hepatoP↑, 2,   IMPDH1↓, 1,   IMPDH2↓, 1,   RenoP↑, 2,   Risk↓, 1,   TumVol↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 327

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↑, 5,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 1,   HO-1↑, 1,   MDA↓, 3,   NRF2↑, 2,   ROS↓, 8,   SOD↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 1,   cAMP↑, 1,   NAD↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,   Casp9↓, 1,   Ferroptosis↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

JNK↓, 1,   MAPK↓, 1,   PP2A↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

DNMT1↓, 6,   DNMT3A↓, 3,   DNMTs↓, 2,   HDAC↓, 3,   HDAC3↓, 1,   KLF4↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,  

Migration(tgid=13) ⓘ

MMP13↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   IBI↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 2,   IL10↑, 1,   IL1β↓, 2,   IL6↓, 2,   Inflam↓, 6,   MCT1↓, 1,   NF-kB↓, 3,   PGE2↓, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 3,   BioAv↝, 1,   Dose↝, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 2,   hepatoP↑, 2,   memory↑, 2,   neuroP↑, 2,   Obesity↓, 1,   radioP↑, 2,   RenoP↑, 3,   toxicity↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 1,  
Total Targets: 72

Scientific Paper Hit Count for: DNMT1, DNA (cytosine-5-)-methyltransferase 1
8 Thymoquinone
6 Sulforaphane (mainly Broccoli)
6 Berberine
5 EGCG (Epigallocatechin Gallate)
4 Curcumin
2 Apigenin (mainly Parsley)
2 Luteolin
2 Quercetin
2 Shikonin
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 Isovitexin
1 Ashwagandha(Withaferin A)
1 Capsaicin
1 Chlorogenic acid
1 Butyrate
1 Emodin
1 Eugenol
1 Evodiamine
1 Hydrogen Gas
1 Magnolol
1 methylseleninic acid
1 Piperlongumine
1 Rutin
1 buckwheat sprouts
1 Silymarin (Milk Thistle) silibinin
1 Selenite (Sodium)
1 Osimertinib
1 Adagrasib
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:85  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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