E-cadherin Cancer Research Results

E-cadherin, E-cadherin: Click to Expand ⟱
Source: HalifaxProj(restore)
Type:
Also known as Cadherin1 (CDH1)
E-cadherin, is a type of cell adhesion molecule that plays a crucial role in maintaining tissue structure and cell-cell interactions. In the context of cancer, E-cadherin has been found to be a tumor suppressor gene.

E-cadherin is a transmembrane protein that mediates cell-cell adhesion through its extracellular domain, which interacts with other E-cadherin molecules on adjacent cells. This interaction helps to maintain tissue integrity and prevent cancer cells from invading surrounding tissues.

In many types of cancer, including breast, colon, and prostate cancer, E-cadherin expression is often reduced or lost.
cell adhesion molecules spanning four families of 1) Integrins (α2β1, α5/β1, αL/β2); 2) Cadherins (E-cad, P-cad, N-cad); 3) Ig-CAMs (VCAM, NCAM, ICAM, Nectins, Necl); and 4) Selectins (E-selectin, P-selectin, L-selectin).
Scientific Papers found: Click to Expand⟱
5965- CEL,  Cisplatin,    Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway
- in-vitro, OS, MG63
COX2/PTGS2↓, ChemoSen↑, MDR1↓, MRP1/ABCC1↓, E-cadherin↓, β-catenin/ZEB1↓, Apoptosis↑, TumCCA↑, TumCG↓, P-gp/ABCB1↓, PI3K↓, Akt↓,
6643- Cen,    Asiaticoside inhibits epithelial-mesenchymal transition and stem cell-like properties of pancreatic cancer PANC-1 cells by blocking the activation of p65 and p38MAPK
- vitro+vivo, PC, PANC1
tumCV↓, Ki-67↓, PCNA↓, N-cadherin↓, Vim↓, SOX2↓, OCT4↓, p65↓, MAPK↓, CD44↓, CD133↓, E-cadherin↑, TumVol↓, TumCP↓, EMT↓, CSCsMark↓,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *Stroke↓, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
1106- CGA,    Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6
- vitro+vivo, BC, MCF7
E-cadherin↑, ZO-1↑, Zeb1↓, N-cadherin↓, Vim↓, Snail↓, Slug↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, LRP6↓, p‑LRP6↓, β-catenin/ZEB1↓, TumVol↓, TumW↓,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, Synergy↑, Synergy↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, Synergy↑,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2/PTGS2↓, Synergy↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, Synergy↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
1107- CHr,    Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway
- in-vitro, BC, NA
TumCP↓, Apoptosis↑, MMP-10↓, E-cadherin↑, Vim↓, Snail↓, Slug↓, EMT↓,
6162- Cin,    Anticancer Potential and Molecular Mechanisms of Cinnamaldehyde and Its Congeners Present in the Cinnamon Plant
- Review, Var, NA
AntiCan↑, Apoptosis↑, ROS↑, BAX↑, Cyt‑c↑, Fas↑, Casp9↑, E-cadherin↑, Casp7↑, PARP↑, Bak↑, AMPK↑, Ca+2↑, BAD↑, MMP↓, cycA1/CCNA1↓, CycB/CCNB1↓, ERK↓, VEGF↓, TumCP↓, MAPK↓, mTOR↓, PI3K↓, PCNA↓, Bcl-2↓, TumCCA↑, angioG↓, *ROS↓, Inflam↓,
6142- Cin,    Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway
- in-vitro, CRC, LoVo - in-vitro, CRC, SW48 - in-vitro, CRC, HCT116
E-cadherin↑, MMP2↓, MMP9↓, PI3K↓, Akt↓, IGF-1↓, Apoptosis↑, BAX↑, cl‑PARP↑, PARP↓, Bcl-2↓, TumCI↓,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, Synergy↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
1587- Citrate,    ATP citrate lyase: A central metabolic enzyme in cancer
- Review, Var, NA
ACLY↓, other↓, PFK1↓, ATP↓, PFK2↓, Mcl-1↓, Casp3↑, Casp2↑, Casp9↑, IGF-1R↓, PI3K↓, Akt↓, p‑Akt↓, p‑ERK↓, PTEN↑, Snail↓, E-cadherin↑, ChemoSen↑,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27/CDKN1B↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
4652- CUR,    Anticancer effect of curcumin on breast cancer and stem cells
- Review, BC, NA
TumCP↓, TumMeta↓, TumCCA↑, Apoptosis↑, CSCs↓, NF-kB↓, Telomerase↓, Cyt‑c↑, Casp9↑, Casp3↑, E-cadherin↑,
464- CUR,    Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p/STAT3 axis
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, TPC-1
TumCI↓, TumCI↓, MMP2↓, MMP9↓, EMT↓, STAT3↓, miR-301a-3p↓, STAT↓, N-cadherin↓, Vim↓, Fibronectin↓, p‑JAK↓, p‑JAK2↓, p‑JAK3↓, p‑STAT1↓, p‑STAT2↓, E-cadherin↑,
473- CUR,    Curcumin inhibits epithelial-mesenchymal transition in oral cancer cells via c-Met blockade
- in-vitro, Oral, HSC4 - in-vitro, Oral, Ca9-22
Vim↓, p‑cMET↓, p‑ERK↓, pro‑MMP9↓, E-cadherin↑,
470- CUR,    Regulation of carcinogenesis and modulation through Wnt/β-catenin signaling by curcumin in an ovarian cancer cell line
- in-vitro, Ovarian, SKOV3
Wnt/(β-catenin)↓, EMT↓, DNMT3A↓, cycD1/CCND1↓, cMyc↓, Fibronectin↓, Vim↓, E-cadherin↑, SFRP5↑,
478- CUR,    Curcumin decreases epithelial‑mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cells
- in-vitro, Cerv, SiHa
EMT↓, N-cadherin↓, Vim↓, Slug↓, Zeb1↓, PIR↓, Pirin↓, E-cadherin↑,
433- CUR,    Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells Through Radiation-Induced Suppression of Epithelial-Mesenchymal Transition and Soluble E-Cadherin Expression
- in-vitro, Lung, A549
E-cadherin↓, Vim↓, Slug↓, N-cadherin↓, Snail↓, MMP9↓, EMT↓,
429- CUR,    TAp63α Is Involved in Tobacco Smoke-Induced Lung Cancer EMT and the Anti-cancer Activity of Curcumin via miR-19 Transcriptional Suppression
- in-vitro, Lung, H1299 - in-vitro, Lung, A549
TAp63α↑, E-cadherin↑, ZO-1↑, Vim↓, N-cadherin↓, miR-19b↓,
413- CUR,    Curcumin attenuates lncRNA H19-induced epithelial-mesenchymal transition in tamoxifen-resistant breast cancer cells
- in-vitro, BC, MCF7
N-cadherin↓, E-cadherin↑, H19↓,
420- CUR,    Anti-metastasis activity of curcumin against breast cancer via the inhibition of stem cell-like properties and EMT
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Vim↓, Fibronectin↓, β-catenin/ZEB1↓, E-cadherin↓, CD44↑, CD24↓, OCT4↓, Nanog↓, SOX2↓,
455- CUR,    Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-β-Catenin
- in-vitro, GC, SGC-7901
Shh↓, Gli1↓, FOXM1↓, β-catenin/ZEB1↓, TumCMig↓, Apoptosis↑, TumCCA↑, Wnt↓, EMT↓, E-cadherin↑, Vim↓,
451- CUR,    The effect of Curcumin on multi-level immune checkpoint blockade and T cell dysfunction in head and neck cancer
- vitro+vivo, HNSCC, SCC15 - vitro+vivo, HNSCC, SNU1076 - vitro+vivo, HNSCC, SNU1041
TumCMig↓, TumCG↓, PD-L1↓, PD-L2↓, Galectin-9↓, EMT↓, T-Cell↑, TILs↑, PD-1↓, TIM-3↓, CD4+↓, CD25+↓, FoxP3+↓, E-cadherin↑, CD8+↑, IFN-γ↑,
447- CUR,  OXA,    Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-β/Smad2/3 signaling pathway
- vitro+vivo, CRC, HCT116
p‑p65↓, Bcl-2↓, Casp3↑, EMT↓, p‑SMAD2↓, p‑SMAD3↓, N-cadherin↓, TGF-β↓, E-cadherin↑, TumVol↓, TumCMig↓,
443- CUR,    Reduced Caudal Type Homeobox 2 (CDX2) Promoter Methylation Is Associated with Curcumin’s Suppressive Effects on Epithelial-Mesenchymal Transition in Colorectal Cancer Cells
- in-vitro, CRC, SW480
DNMT1↓, DNMT3A↓, N-cadherin↓, Vim↓, Wnt↓, Snail↓, Twist↓, β-catenin/ZEB1↓, E-cadherin↑, EMT↓, CDX2↓,
442- CUR,  5-FU,    Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress
- in-vitro, CRC, HCT116
Apoptosis↑, TumCP↓, TumCCA↑, TET1↑, NKD2↑, Wnt↓, EMT↓, Vim↑, E-cadherin↓, β-catenin/ZEB1↓, TCF↓, AXIN1↓,
11- CUR,    Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway
- in-vitro, PC, PANC1
HH↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, E-cadherin↑, Vim↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓, chemoPv↑,
2974- CUR,    Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT15 - in-vitro, CRC, COLO205 - in-vitro, CRC, SW-620 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumCG↓, TumMeta↓, Sp1/3/4↓, HDAC4↓, FAK↓, CD24↓, E-cadherin↑, EMT↓, TumCP↓, NF-kB↓, AP-1↝, STAT3↓, P53?, β-catenin/ZEB1↓, NOTCH1↝, Hif1a↝, PPARα↝, Rho↓, MMP2↓, MMP9↓,
6245- Cyc,    Blockade of Hedgehog Signaling Inhibits Pancreatic Cancer Invasion and Metastases: A New Paradigm for Combination Therapy in Solid Cancers
- vitro+vivo, PC, NA
HH↓, Snail↓, E-cadherin↑, EMT↓, TumCI↓, ChemoSen↑, TumMeta↓, ALDH↓, eff↑,
6248- Cyc,    The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells
- in-vitro, CRC, NA
HH↓, Apoptosis↑, Slug↓, Snail↓, Twist↓, EMT↓, β-catenin/ZEB1↓, E-cadherin↑, TumCI↓,
16- Cyc,  RES,    Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis
- in-vitro, GC, SGC-7901
HH↓, Gli1↓, EMT↓, N-cadherin↓, E-cadherin↑, Snail↓, TumCI↓, TumMeta↓,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, Synergy↑, ROS↑, Akt↑, Casp3↑,
8851- DIM,    3,3’-Diindolylmethane and its derivatives: nature-inspired strategies tackling drug resistant tumors by regulation of signal transduction, transcription factors and microRNAs
- Review, Var, NA
Apoptosis↑, NF-kB↓, Akt↓, Wnt↓, PI3K↓, mTOR↓, PSA↓, Let-7↓, miR-34a↓, EZH2↓, NOTCH1↓, AR↓, E-cadherin↑, Zeb1↓, Vim↓, Slug↓, EMT↓, MTA2↓, NF-kB↓, IRAK1↓, EGFR↓, SOX4↓, FOXM1↓, p27/CDKN1B↓, AhR↓, EZH2↓, Wnt↓, PUMA↓, AEG1↑, ROS↑, PPARα↑, CycB/CCNB1↑,
8845- DIM,  I3C,    3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways
- Review, Var, NA
*BioAv↝, *BioAv↓, *BioAv↓, *AntiAg↑, *ROS↓, *AntiThr↑, *Stroke↓, *CYP1A1↑, *CYP1A2↑, *GSTs↑, *NQO1↑, AntiTum↑, AntiCan↑, TumAuto↓, Let-7↑, miR-34a↑, TumCMig↓, Apoptosis↑, MMP↓, mtDam↑, ROS↑, TumCCA↑, other↝, PSA↓, Dose↝, MMP2↓, MMP3↓, MMP9↓, EGFR↓, RAS↓, PI3K↓, Akt↓, mTOR↓, CDK4↓, cycD1/CCND1↓, P21↑, MDM2↓, TumCP↓, NF-kB↓, RANKL↓, PUMA↓, Wnt↓, MTA2↓, EZH2↓, AhR↓, PTEN↑, NOTCH1↓, IRAK1↓, p27/CDKN1B↓, CDKN1C/p57↓, CDC25↓, EGFR↓, Zeb1↓, FOXM1↓, SOX4↓, E-cadherin↑, uPA↓, uPAR↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2/PTGS2↓, Hif1a↓, VEGF↓, VEGFR2/KDR/Flk1↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
7193- EGb 761,  5-FU,    Ginkgo biloba extract 761 enhances 5-fluorouracil chemosensitivity in colorectal cancer cells through regulation of high mobility group-box 3 expression
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
*antiOx↑, AntiCan↑, ChemoSen↑, selectivity↑, EMT↓, E-cadherin↑, Vim↓, HMGB1↓, other↝, chemoPv↑,
4685- EGCG,    Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition in nasopharyngeal cancer cell lines
- in-vitro, NPC, TW01 - in-vitro, NPC, TW06
CSCs↓, EMT↓, TumCMig↓, TumCI↓, OCT4↓, Snail↓, Vim↓, E-cadherin↓, HSP70/HSPA5↓, HSP90↓, AntiTum↓,
6823- EMD,    Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
- Review, Var, NA
AntiCan↑, *antiOx↑, *chemoP↑, *Inflam↓, TumCP↓, TumMeta↓, TumCCA↑, MAPK↑, BAX↑, Casp↑, ROS↑, *BioAv↓, other↝, TumCI↓, EMT↓, TumCG↑, Apoptosis↑, TumCP↑, MMP2↓, Casp3↑, ChemoSen↑, PI3K↓, Akt↓, Cyt‑c↑, cl‑PARP↑, MMP↓, Warburg↓, HK2↓, PKM2↓, LDHA↓, mtDam↑, Apoptosis↑, N-cadherin↓, Vim↓, E-cadherin↑, eff↑, eff↑, eff↑, toxicity↝, toxicity↑,
1247- EMD,    Emodin exerts antitumor effects in ovarian cancer cell lines by preventing the development of cancer stem cells via epithelial mesenchymal transition
- vitro+vivo, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S
TumCP↓, TumCMig↓, TumCI↓, EMT↓, N-cadherin↓, Vim↓, E-cadherin↑, TumCG↓, CD133↓, OCT4↓, CSCs↓,
6580- EU,    Eurycomanone Blocks TGF-β1-Induced Epithelial-to-Mesenchymal Transition, Migration, and Invasion Pathways in Human Non-Small Cell Lung Cancer Cells by Targeting Smad and Non-Smad Signaling
- in-vitro, Lung, A549 - in-vitro, Lung, Calu-1
TumCMig↓, MMP2↓, EMT↓, E-cadherin↑, Akt↓, N-cadherin↓, TGF-β↓, Smad1↓,
6390- Eug,    Molecular mechanisms of eugenol as an antitumour bioactive compound: A comprehensive review
- Review, Var, NA
TumCCA↑, angioG↓, TumMeta↓, tumCV↓, Casp3↑, Casp6↑, DFF45↑, PARP↑, ROS↑, Cyt‑c↑, MPT↑, *ROS↓, NF-kB↓, COX2/PTGS2↓, 5LO↓, EMT↓, Snail↓, E-cadherin↑, Vim↓, PI3K↓, Akt↓, mTORC2↓, TumAuto↑, FOXO3↓, Apoptosis↑, ChemoSen↑, RadioS↑, DNMT1↓, DNMT3A↓,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑, CompStab↑,
6330- Eug,    Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement
- Review, Var, NA
TumCD↑, TumCCA↑, AntiCan↑, Apoptosis↑, angioG↓, TumCI↓, TumMeta↓, ChemoSen↑, ALDH↓, NF-kB↓, IL6↓, IL8↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Snail↓, E-cadherin↑, SOX2↓, ROS↑, PCNA↓, MMP1↓, Cyt‑c↑, LDH↑, CSCs↓, OCT4↓, NOTCH1↓, EpCAM↓, CD44↓, HER2/EBBR2↓, VEGF↓, TIMP2↑, eff↑, Ca+2↑, TumVol↓, DNAdam↑, GSH↓, H2O2↑, lipid-P↑,
6846- EVO,    Evodiamine Inhibits Colorectal Cancer Growth via RTKs Mediated PI3K/AKT/p53 Signaling Pathway
- in-vitro, CRC, HT29 - in-vitro, CRC, HCT116
TumCP↓, TumCI↓, TumCCA↑, PI3K↓, AKT1↓, P53↑, Bcl-2↓, BAX↑, Apoptosis↑, p‑Casp9↑, E-cadherin↑, N-cadherin↓, MMP9↓, CSCs↓, EGFR↓, PDGFRA↓, Dose↝, TumCG↓,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
6915- FIS,  SRF,    Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma
- in-vitro, Melanoma, NA
EMT↓, TumCP↓, PI3K↓, Synergy↑, N-cadherin↓, Vim↓, Fibronectin↓, E-cadherin↑, Snail↓, Twist↓, Slug↓, Zeb1↓, MMP2↓, MMP9↓, TumCI↓, TumMeta↓, ChemoSen↑,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, Synergy↑, ChemoSen↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, Synergy↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,

Showing Research Papers: 51 to 100 of 248
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 248

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ARE↑, 1,   Catalase↓, 5,   Catalase↑, 1,   Copper↑, 1,   ENOX2↓, 1,   GPx↓, 3,   GPx4↓, 4,   GSH↓, 12,   GSH↑, 2,   GSR↓, 1,   GSTs↓, 2,   GSTs↑, 2,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 8,   Iron↑, 1,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 1,   MPO↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 9,   NRF2↑, 7,   p‑NRF2↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 12,   ROS↑, 85,   ROS⇅, 3,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SOD↓, 9,   SOD↑, 3,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   TAC?, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR↓, 2,   TrxR↑, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 6,   CDC25↓, 5,   compI↓, 2,   compIII↓, 2,   compV↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   Insulin↓, 1,   MFN2↓, 1,   mitResp↓, 3,   MKK7↓, 1,   mtDam↑, 13,   OCR↓, 4,   OXPHOS↓, 1,   OXPHOS↝, 1,   PDH↓, 1,   PDH↑, 1,   PDH↝, 1,   PINK1↑, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 2,   ACC-α↓, 1,   ACC1↓, 1,   ACLY↓, 2,   p‑ACLY↓, 1,   adiP↑, 1,   ALAT↓, 2,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 15,   AMPK↝, 1,   p‑AMPK↑, 2,   ATP↓, 8,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   ECAR↓, 1,   FASN↓, 3,   GAPDH↓, 1,   glucose↝, 1,   GlucoseCon↓, 5,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 14,   GSK‐3β↓, 6,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 6,   HK1↓, 1,   HK2↓, 11,   HMG-CoA↓, 1,   lactateProd↓, 5,   LDHA↓, 4,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 2,   NADPH↓, 4,   NADPH↑, 1,   PCK1↓, 1,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 2,   PFK↓, 1,   PFK1↓, 2,   PFK2↓, 1,   PIP3↑, 1,   PKM2↓, 5,   Pyruv↑, 1,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   SIRT1↓, 7,   SIRT1↑, 3,   SIRT2↓, 1,   SREBP1/SREBF1↓, 3,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 80,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 6,   Bak↑, 4,   BAX↓, 1,   BAX↑, 55,   Bax:Bcl2↑, 10,   Bcl-2↓, 63,   Bcl-2↑, 2,   Bcl-xL↓, 11,   Bcl-xL↑, 1,   BID↑, 2,   BIM↑, 8,   BNIP3↑, 2,   BOK↑, 1,   Casp↑, 12,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 1,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 55,   cl‑Casp3↑, 16,   Casp6↑, 1,   Casp7↑, 7,   cl‑Casp7↑, 2,   Casp8↑, 11,   cl‑Casp8↑, 3,   Casp9↓, 1,   Casp9↑, 40,   p‑Casp9↑, 1,   cl‑Casp9↑, 5,   proCasp9↓, 1,   CellShr↑, 2,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 41,   mt-Cyt‑c↓, 1,   Diablo↑, 7,   DR5↑, 11,   FADD↑, 3,   Fas?, 1,   Fas↑, 13,   FasL↑, 1,   Ferroptosis↑, 3,   GSDMD↑, 1,   HEY1↓, 1,   IAP1↓, 3,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 7,   Mcl-1↓, 9,   MDM2↓, 6,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   NAIP↓, 1,   NOXA↑, 1,   oncosis↑, 1,   p38↓, 3,   p38↑, 4,   p‑p38↓, 4,   p‑p38↑, 2,   PUMA↓, 2,   PUMA↑, 2,   Pyro↑, 1,   survivin↓, 16,   survivin↝, 1,   TNFR 1↑, 2,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 4,   XIAP↓, 13,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 64,   Akt↑, 3,   p‑Akt↓, 23,   AKT1↓, 3,   Akt2↓, 1,   CIP2A↓, 1,   CK2↓, 5,   cMET↓, 2,   p‑cMET↓, 1,   cSrc↓, 1,   EGFR↓, 20,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 20,   ERK↑, 3,   p‑ERK↓, 9,   ERK5↑, 1,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 2,   IGFR↓, 1,   IKKα↓, 4,   p‑IκB↓, 2,   JAK↓, 2,   p‑JAK↓, 1,   JAK1↓, 2,   JAK2↓, 3,   p‑JAK2↓, 2,   JAK3↓, 1,   p‑JAK3↓, 1,   JNK↓, 1,   JNK↑, 4,   p‑JNK↓, 2,   p‑JNK↑, 1,   LIMK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 12,   MAPK↑, 5,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MARK4↓, 2,   MEK↓, 1,   MKK4↓, 1,   mTOR↓, 42,   mTOR↑, 1,   mTOR↝, 1,   p‑mTOR↓, 7,   mTORC2↓, 2,   p42↑, 1,   p70S6↓, 1,   PDGFRA↓, 2,   PI3K↓, 58,   PI3K↑, 1,   p‑PI3K↓, 5,   p‑PI3K↑, 1,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   PKCδ↓, 3,   PTEN↓, 2,   PTEN↑, 16,   Raf↓, 1,   RAS↓, 4,   SHP1↑, 1,   Sp1/3/4↓, 5,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 1,   p‑STAT2↓, 1,   STAT3↓, 39,   p‑STAT3↓, 8,   p‑STAT3↑, 1,   STAT5↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 7,   p‑ATF4↝, 1,   cJun↓, 6,   cMyc↓, 26,   p‑cMyc↑, 1,   CREBBP↓, 1,   DNMT1↓, 3,   DNMT3A↓, 3,   DNMTs↓, 4,   EZH2↓, 7,   FOXM1↓, 4,   FOXO1↓, 3,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 2,   p‑FOXO3↓, 1,   FOXO4↓, 2,   FOXO4↑, 1,   H19↓, 1,   H3↓, 2,   p‑H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 1,   H3K27ac↓, 1,   H4↓, 1,   ac‑H4↓, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 12,   HDAC1↓, 4,   HDAC2↓, 4,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 1,   HES1↓, 1,   HOXB-AS1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-139-5p↑, 2,   miR-140↑, 1,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-19b↓, 2,   miR-200b↑, 1,   miR-200c↑, 2,   miR-203↑, 1,   miR-205↑, 1,   miR-21↓, 3,   miR-224↓, 1,   miR-29b↓, 1,   miR-301a-3p↓, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 2,   miR-375↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   miR-448↑, 1,   miR-592↑, 1,   MTA2↓, 2,   Myc↓, 2,   NDRG1↑, 2,   OCT4↓, 12,   OCT4↑, 1,   other↓, 3,   other↑, 2,   other↝, 4,   other∅, 2,   PAX2↓, 1,   SOX2↓, 9,   SOX4↓, 2,   SOX4↑, 1,   TCF-4↓, 1,   tumCV↓, 16,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 9,   p‑CHOP/DDIT3↝, 1,   eIF2α↑, 2,   p‑eIF2α↑, 5,   p‑eIF2α↝, 1,   ER Stress↓, 1,   ER Stress↑, 14,   Erlin1↑, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 5,   HSP70/HSPA5↓, 5,   HSP90↓, 3,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 5,   p‑PERK↝, 1,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 8,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 2,   LC3B↑, 1,   LC3B-II↑, 2,   LC3II↓, 1,   LC3II↑, 8,   LC3s↑, 1,   LysoPr↑, 1,   MitoP↑, 1,   p62↓, 8,   PARK2↑, 2,   TumAuto↓, 1,   TumAuto↑, 13,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   ATM↑, 1,   BRCA1↓, 2,   DFF45↑, 2,   DNAdam↑, 20,   DNAdam⇅, 1,   mt-DNAdam↑, 1,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC3↑, 1,   hTERT/TERT↓, 9,   p16↑, 1,   P53?, 1,   P53↓, 1,   P53↑, 32,   p‑P53↑, 1,   ac‑P53↑, 1,   p53 Wildtype↑, 1,   PARP↓, 1,   PARP↑, 9,   cl‑PARP↑, 27,   PARP1↑, 2,   cl‑PARP1↑, 2,   PCNA↓, 18,   PCNA↑, 1,   POLD1↓, 1,   RAD51↓, 1,   Telomerase↓, 8,   TOP1↓, 4,   TOP2↓, 6,   TP53↑, 2,   XRCC1↓, 1,   γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 8,   CDK1/2/5/9↓, 1,   CDK2↓, 22,   CDK2↑, 2,   CDK4↓, 26,   CDK4↑, 1,   CDK6↓, 11,   CDK6↑, 1,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 2,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 13,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 41,   CycD3↓, 1,   cycE/CCNE↓, 8,   E2Fs↓, 1,   E2Fs↑, 1,   Ki-67↓, 17,   MAD↓, 1,   MKI67↑, 1,   P21↑, 26,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 13,   pRB↓, 1,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   Securin↓, 1,   TAp63α↑, 1,   TumCCA↓, 4,   TumCCA↑, 79,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   ALDH1A1↓, 2,   AXIN1↓, 1,   AXIN1↑, 1,   Axin2↓, 1,   BMI1↓, 2,   BMPs↑, 1,   CD133↓, 4,   CD24↓, 2,   CD34↓, 1,   CDX2↓, 1,   cFos↓, 6,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 30,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 9,   GTPBP4↓, 1,   HH↓, 8,   IGF-1↓, 6,   IGFBP1↑, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Ki-67↓, 17,   Let-7↓, 1,   Let-7↑, 5,   LRP6↓, 1,   p‑LRP6↓, 1,   MSCmark↓, 1,   mTORC1↓, 2,   Nanog↓, 10,   Nanog↑, 1,   Nestin↓, 1,   NICD↓, 1,   NKD2↑, 1,   NOTCH↓, 8,   NOTCH⇅, 1,   NOTCH1↓, 13,   NOTCH1↑, 2,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH2↑, 1,   NOTCH3↓, 1,   p300↓, 1,   Piezo1↑, 1,   Pirin↓, 1,   PTCH1↓, 1,   SFRP5↑, 1,   Shh↓, 6,   Smo↓, 4,   p‑STAT1↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG↓, 45,   TumCG↑, 3,   TumCP?, 1,   TumCP↓, 70,   TumCP↑, 4,   tyrosinase↓, 1,   Wnt↓, 29,   Wnt/(β-catenin)↓, 4,   Wnt/(β-catenin)↑, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 2,   AEG1↑, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 4,   AP-1↝, 1,   AXL↓, 1,   CA↓, 1,   Ca+2↑, 20,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↑, 2,   Cal9↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 5,   COL1A1↓, 1,   COL3A1↓, 1,   COL4↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 30,   E-cadherin↑, 211,   E-cadherin↝, 1,   EM↑, 1,   EMT↓, 148,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 2,   F-actin↑, 1,   FAK↓, 7,   FAK↑, 1,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 15,   Fibronectin↑, 1,   Galectin-9↓, 1,   GIT1↓, 1,   GLI2↓, 2,   ITGA5↑, 1,   ITGB1↓, 1,   ITGB1↑, 1,   ITGB4↓, 1,   LAMA5↑, 1,   LEF1↓, 1,   MALAT1↓, 3,   MET↓, 3,   MET↑, 2,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 3,   MMP1:TIMP1↑, 1,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 88,   MMP2↝, 1,   MMP3↓, 6,   MMP7↓, 10,   MMP9↓, 88,   MMP9↝, 1,   pro‑MMP9↓, 1,   MMPs↓, 17,   MTA1↓, 1,   MUC1↑, 1,   N-cadherin↓, 107,   N-cadherin↑, 3,   N-cadherin↝, 1,   p44↑, 1,   p‑pax↓, 1,   PDGF↓, 2,   PIR↓, 1,   Rac1↓, 1,   Rho↓, 4,   ROCK1↓, 3,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 31,   Smad1↓, 3,   SMAD2↓, 4,   p‑SMAD2↓, 7,   SMAD3↓, 5,   p‑SMAD3↓, 6,   Snail?, 1,   Snail↓, 74,   Snail↑, 4,   TET1↑, 3,   TGF-β↓, 14,   TGF-β↑, 2,   TGF-β1↓, 2,   TIMP1↓, 2,   TIMP1↑, 5,   TIMP2↓, 3,   TIMP2↑, 5,   TIMP3↑, 1,   TSP-1↑, 3,   TumCA↓, 2,   TumCI?, 2,   TumCI↓, 83,   TumCI↑, 1,   TumCMig?, 1,   TumCMig↓, 90,   TumCMig↑, 1,   TumMeta↓, 53,   TumMeta↑, 2,   Twist↓, 34,   Twist↑, 2,   Tyro3↓, 1,   uPA↓, 15,   uPAR↓, 2,   Vim?, 1,   Vim↓, 128,   Vim↑, 6,   vinculin↓, 1,   Zeb1↓, 31,   Zeb1↑, 2,   ZEB2↓, 3,   ZEB2↑, 2,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↓, 55,   β-catenin/ZEB1↑, 1,   p‑β-catenin/ZEB1↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 34,   angioG↑, 3,   CD31/PECAM-1↓, 3,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 29,   Hif1a↑, 1,   Hif1a↝, 1,   NO↓, 3,   NO↑, 1,   NO↝, 1,   TXA2↓, 1,   VCAM-1↓, 2,   VEGF↓, 59,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 10,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   CLDN1↓, 4,   CLDN2↓, 1,   CLDN2↑, 1,   CLDN7↑, 1,   GLUT1↓, 2,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↑, 1,   MMP↓, 42,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,   OCLN↑, 1,   TRPV1↑, 1,   ZO-1↑, 10,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↓, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 10,   CD44↑, 1,   CD59↑, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 37,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 2,   CXCL12↓, 1,   CXCR4↓, 9,   DR4↑, 2,   Eos↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   FoxP3+↓, 1,   HMGB1↓, 3,   ICAM-1↓, 4,   IFN-γ↓, 3,   IFN-γ↑, 2,   Igs↑, 1,   IL1↓, 2,   IL10↓, 3,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 9,   IL2↓, 2,   IL2↑, 2,   IL4↑, 1,   IL5↓, 1,   IL6↓, 21,   IL6↑, 1,   IL8↓, 11,   IL8↑, 1,   Imm↑, 4,   Imm↝, 1,   Inflam↓, 8,   IRAK1↓, 2,   pol-M1↑, 1,   MCP1/CCL2↓, 2,   MIP-1β↑, 1,   Neut↑, 1,   NF-kB↓, 65,   NF-kB↑, 2,   p‑NF-kB↑, 2,   NK cell↑, 4,   NLRP3↓, 3,   p50↓, 2,   p65↓, 4,   p65↑, 1,   p‑p65↓, 3,   PD-1↓, 4,   PD-L1↓, 6,   PD-L1↑, 1,   PD-L2↓, 1,   PGE2↓, 13,   PSA↓, 6,   RAGE↓, 1,   T-Cell↑, 2,   TCF↓, 3,   TCF↑, 1,   Th1 response↑, 3,   Th17↑, 1,   TILs↑, 1,   TIM-3↓, 1,   TLR4↓, 2,   TNF-α↓, 12,   TNF-α↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↓, 1,   AR↓, 7,   AR↑, 1,   ER(estro)↓, 1,   FGF21↓, 1,   PPARα↓, 1,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 2,   RANKL↓, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 13,   BioAv↝, 5,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 59,   ChemoSen⇅, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP3A4↓, 1,   Dose↑, 3,   Dose↝, 21,   Dose∅, 5,   eff↓, 9,   eff↑, 21,   eff↝, 7,   eff∅, 1,   Half-Life↓, 6,   Half-Life↑, 1,   Half-Life↝, 3,   MDR1↓, 5,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 4,   P450↓, 3,   RadioS↑, 23,   selectivity↑, 27,   selectivity↝, 1,   Synergy?, 1,   Synergy↑, 56,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 7,   AR↑, 1,   AST↓, 1,   BRCA1↓, 2,   CEA↓, 1,   CRP↓, 1,   EGFR↓, 20,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 7,   Ferritin↓, 1,   FOXM1↓, 4,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 9,   IL6↓, 21,   IL6↑, 1,   LDH↓, 6,   LDH↑, 1,   Myc↓, 2,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PSA↓, 6,   RAGE↓, 1,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 21,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↓, 1,   AntiTum↑, 12,   cachexia↓, 3,   cardioP↑, 6,   chemoP↑, 12,   chemoPv↑, 6,   ChemoSideEff↓, 5,   fatigue↓, 1,   hepatoP↑, 5,   neuroP↑, 4,   NKG2D↑, 1,   OS↑, 11,   Pain↓, 1,   Pin1↓, 1,   QoL↑, 1,   radioP↑, 4,   RenoP↑, 3,   Risk↓, 5,   toxicity?, 1,   toxicity↓, 6,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 2,   TumVol↓, 10,   TumW↓, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 6,  
Total Targets: 891

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 31,   Catalase↑, 18,   GPx↓, 1,   GPx↑, 12,   GSH↑, 12,   GSR↑, 2,   GSTs↑, 6,   HDL↑, 1,   HO-1↑, 8,   Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 14,   MDA↓, 8,   MPO↓, 1,   NQO1↑, 3,   NRF2↑, 18,   RNS↓, 1,   ROS↓, 39,   SOD↓, 1,   SOD↑, 19,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 1,   ALAT↓, 5,   AMPK↑, 2,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   GSK‐3β↓, 1,   LDHA↑, 1,   lipidLev↓, 1,   NAD↑, 1,   NH3↓, 1,   PLA2↓, 1,   SIRT1↑, 5,  

Cell Death(tgid=5) ⓘ

BAX↓, 3,   Bcl-2↑, 1,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 6,   Casp9↓, 3,   Cyt‑c↓, 3,   Ferroptosis↓, 1,   iNOS↓, 3,   MLKL↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 4,   p‑Akt↓, 1,   p‑Akt↑, 1,   CaMKII ↓, 1,   CREB↑, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   IκB?, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 5,   mTOR↑, 3,   p‑mTOR↓, 1,   PI3K↓, 3,   PI3K↑, 4,   PKCδ↓, 1,   PTEN↑, 1,   RAS↓, 1,   RIP1↓, 1,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   p‑cMyc↑, 1,   HDAC↓, 1,   HOTAIR↑, 1,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   IRE1↓, 1,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 3,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↝, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 1,   Ca+2↝, 1,   cal2↓, 1,   COL1↓, 3,   COL1↑, 1,   COL3A1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 7,   EMT↓, 4,   EMT↑, 1,   F-actin↓, 1,   Fibronectin↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Smad7↑, 2,   Snail↓, 1,   TGF-β↓, 2,   TGF-β1↓, 1,   TIMP1↓, 1,   TregCell↑, 1,   TumCMig↓, 1,   TumMeta↓, 1,   Vim↓, 6,   Zeb1↓, 1,   α-SMA↓, 6,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   Hif1a↓, 1,   NO↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   IBI↑, 2,   MMP↑, 3,   TRPC1↓, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 8,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 2,   IL12↓, 1,   IL1RL1/ST2↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL33↓, 1,   IL4↓, 1,   IL5↓, 2,   IL6↓, 11,   IL8↓, 2,   ILC2↓, 1,   Imm↑, 2,   Inflam↓, 31,   Inflam↑, 1,   LPS↓, 1,   NeuroI↓, 1,   NF-kB↓, 10,   NK cell↑, 1,   PGE2↓, 7,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 1,   TLR4↓, 4,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 5,   BDNF↑, 1,   MAOA↓, 1,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   BACE/β-secretase↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   BNP↓, 1,   CYP19↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 18,   BioAv↑, 5,   BioAv↝, 5,   BioEnh↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose↝, 1,   eff↑, 2,   GSTA1↑, 1,   Half-Life↝, 3,   P450↓, 2,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALP↓, 3,   AST↓, 7,   BP↓, 1,   BUN↓, 1,   creat↓, 2,   CRP↓, 1,   IL6↓, 11,   LDH↓, 2,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 7,   AntiArt↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 6,   AntiTum↑, 4,   cardioP↑, 13,   CardioT↓, 1,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 4,   hepatoP↑, 13,   Learn↑, 1,   memory↑, 7,   motorD↑, 1,   Mucositis↓, 2,   neuroP↑, 19,   Obesity↓, 2,   radioP↑, 1,   RenoP↑, 3,   Stroke↓, 3,   toxicity↓, 10,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   GutMicro↑, 3,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 228

Scientific Paper Hit Count for: E-cadherin, E-cadherin
16 Curcumin
11 Resveratrol
11 Luteolin
8 Sulforaphane (mainly Broccoli)
7 Fisetin
7 Quercetin
6 Pterostilbene
6 Thymoquinone
5 Honokiol
5 Matrine
4 Astragalus
4 Cisplatin
4 Apigenin (mainly Parsley)
4 Artemisinin
4 Berberine
4 Benzyl isothiocyanate
4 Chrysin
4 Inositol
4 Piperine
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
3 Baicalein
3 Propolis -bee glue
3 Cinnamon
3 5-fluorouracil
3 Cyclopamine
3 Eugenol
3 phytic acid, Inositol hexakisphosphate
3 Isorhamnetin
3 Magnolol
3 Urolithin
2 Allicin (mainly Garlic)
2 Baicalin
2 Biochanin A
2 Betulinic acid
2 Boron
2 Capsaicin
2 Carvacrol
2 Chlorogenic acid
2 Hydroxycinnamic-acid
2 Citric Acid
2 Diindolylmethane
2 Ellagic acid
2 Emodin
2 Fucoidan
2 Garcinol
2 Grapeseed extract
2 Hydrogen Gas
2 Isoliquiritigenin
2 Isothiocyanates
2 Phenethyl isothiocyanate
2 Juglone
2 Kaempferol
2 Laetrile B17 Amygdalin
2 Lycopene
2 Marjoram (Origanum majorana)
2 Phycocyanin
2 Piperlongumine
2 Shikonin
2 Selenite (Sodium)
2 Ursolic acid
2 Vitamin D3
2 VitK3,menadione
1 1,8-Cineole
1 3-bromopyruvate
1 Alpha-Lipoic-Acid
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Aspirin
1 Astaxanthin
1 Beta-Caryophyllene
1 Boswellia (frankincense)
1 brusatol
1 Butyrate
1 Caffeic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cannabidiol
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Crocetin
1 Oxaliplatin
1 diet FMD Fasting Mimicking Diet
1 Indole-3-carbinol
1 Ginkgo biloba-EGb 761
1 EGCG (Epigallocatechin Gallate)
1 Eurycomanone
1 Evodiamine
1 Ferulic acid
1 Sorafenib (brand name Nexavar)
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Paclitaxel/Taxol
1 Ginkgo biloba
1 Ginkgolide B
1 Proanthocyanidins
1 Chemotherapy
1 HydroxyTyrosol
1 capecitabine
1 Allyl isothiocyanate
1 L-Theanine
1 Licorice
1 Metformin
1 Mangiferin
1 Melatonin
1 Morin
1 Naringin
1 Oroxylin-A
1 Oleuropein
1 Phenylbutyrate
1 Docetaxel
1 Rutin
1 salinomycin
1 Selenate
1 Sesamin
1 Spirulina(Arthrospira/Limnospira)
1 statins
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:89  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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