CDK4 Cancer Research Results

CDK4, Cyclin-dependent kinase 4: Click to Expand ⟱
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Cyclin-dependent kinase 4 (CDK4) is a key regulator of the cell cycle, particularly in the transition from the G1 phase to the S phase. Its expression and activity are often altered in various cancers, contributing to tumorigenesis.
CDK4 is frequently overexpressed in various cancers, and its expression levels can serve as a prognostic marker.
Scientific Papers found: Click to Expand⟱
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, Synergy↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, Synergy↑,
8857- DIM,    Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells
- in-vitro, CRC, HT-29
Dose↝, TumCCA↑, CDK2↓, E2Fs↓, cycA1/CCNA1↓, cycD1/CCND1↓, CDK4↓, P21↑, p27/CDKN1B↑, CDC2↓, CDC25↓,
8838- DIM,    3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, p27/CDKN1B↑, other↝,
8845- DIM,  I3C,    3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways
- Review, Var, NA
*BioAv↝, *BioAv↓, *BioAv↓, *AntiAg↑, *ROS↓, *AntiThr↑, *Stroke↓, *CYP1A1↑, *CYP1A2↑, *GSTs↑, *NQO1↑, AntiTum↑, AntiCan↑, TumAuto↓, Let-7↑, miR-34a↑, TumCMig↓, Apoptosis↑, MMP↓, mtDam↑, ROS↑, TumCCA↑, other↝, PSA↓, Dose↝, MMP2↓, MMP3↓, MMP9↓, EGFR↓, RAS↓, PI3K↓, Akt↓, mTOR↓, CDK4↓, cycD1/CCND1↓, P21↑, MDM2↓, TumCP↓, NF-kB↓, RANKL↓, PUMA↓, Wnt↓, MTA2↓, EZH2↓, AhR↓, PTEN↑, NOTCH1↓, IRAK1↓, p27/CDKN1B↓, CDKN1C/p57↓, CDC25↓, EGFR↓, Zeb1↓, FOXM1↓, SOX4↓, E-cadherin↑, uPA↓, uPAR↓,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, Synergy↑, COX2/PTGS2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
6801- EA,    A radiotherapeutic paradox: ellagic acid sensitizes tumors while attenuating radiation-induced myocardial injury
- vitro+vivo, BC, 4T1
TumCCA↑, CDK4↓, RadioS↑, TumCG↓, *radioP↑, *cardioP↑, *antiOx↑, *ROS↓, Dose↑, selectivity↑, BioAv↓,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑, CompStab↑,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, Synergy↑, Synergy↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
7513- FA,    Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP
- in-vitro, Thyroid, NA
cycD1/CCND1↓, URGCP/URG4↓, CDK4↓, CDK6↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, BAX↑, Casp3↑, Casp9↑, TIMP1↑, TumCI↓, TumCMig↓, TumCCA↑, Apoptosis↑,
7512- FA,    Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro
- in-vitro, PC, MIA PaCa-2
cycD1/CCND1↓, CDK4↓, CDK6↓, Casp10↓, Casp8↓, P53↑, BAX↑, PTEN↑, Casp3↑, Casp9↑, TumCCA↑, TumCI↑,
7507- FA,    Assessment of the anticancer mechanism of ferulic acid via cell cycle and apoptotic pathways in human prostate cancer cell lines
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Dose↝, ATR↑, ATM↑, P21↑, p27/CDKN1B↑, E2F4↑, RB1↑, TP53↑, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, TumCP↓, Casp1↑, Casp2↑, Casp8↑, Fas↑, TRADD↑, Bcl-2↓, XIAP↓, TumCCA↑,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, Synergy↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX/CA9↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
1655- FA,    Ferulic acid inhibiting colon cancer cells at different Duke’s stages
- in-vitro, Colon, SW480 - in-vitro, Colon, Caco-2 - in-vitro, Colon, HCT116
TumCP↓, TumCMig↓, TumCCA↑, Apoptosis↑, ATM↑, Chk2↑, ATR↑, CHK1↑, CK2↓, cycA1/CCNA1↑, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
6922- FIS,    Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin
- Review, Var, NA
*memory↑, *Inflam↓, *5LO↓, *lipid-P↓, *NF-kB↓, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, *ROS↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumCMig↓, MMPs↓, PSA↓,
6899- FIS,    Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1
Dose↝, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↑, CDK4↑, CDK6↑, P21↑, p27/CDKN1B↑, Apoptosis↑, cl‑PARP↑, Cyt‑c↑, XIAP↓, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, PI3K↓, Akt↓,
6902- FIS,    Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
P53↑, NF-kB↓, TumCP↓, Apoptosis↑, TumCCA↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK4↓, CDK2↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓,
6994- FIS,    Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells
- in-vitro, Colon, HT29
TumCG↓, TumCCA↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑,
2852- FIS,    A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
- Review, CRC, NA
Risk↓, P53↑, MDM2↓, COX2/PTGS2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, Synergy↑, ChemoSen↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, Synergy↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, Synergy↑, Synergy↑, Synergy↑, RadioS↑, ChemoSen↑, Half-Life↝,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1/ATG6↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2828- FIS,    Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
- Review, Var, NA
*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP/DDIT3↑, ROS↑, cMyc↓, cardioP↑,
2829- FIS,    Fisetin: An anticancer perspective
- Review, Var, NA
TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP/DDIT3↑, CD44↓, CD133↓, uPA↓, CSCs↓,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, Synergy↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, Synergy↑,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
6985- Form,    Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
CDK4↓, Raf↓, miR-195↑, miR-545↑, ChemoSen↑, AFAP1-AS1↓,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
8586- FS,    The Role of Flaxseed in Improving Human Health
- Review, Nor, NA
*lipidLev↓, *BP↓, *HOMA↓, *AntiCan↑, *antiOx↑, *BioAv↑, *Ingr↑, *Ingr↝, *Ingr↝, *GutMicro↑, *CompStab↝, *TC↓, *TG/TAG↓, *LDL↓, *HDL↑, *BP↓, *AntiDiabetic↑, *AntiCan↑, TumCD↑, selectivity↑, TumCP↓, Apoptosis↑, DNAdam↑, i-ROS↑, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, ChemoSen↑, Synergy↑, *Inflam↓, *hs-CRP↓, *VCAM-1↓, *BDNF↑,
7005- Fuc,    Fucoidan and cancer: a multifunctional molecule with anti-tumor potential
- Review, Var, NA
AntiCan↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, MMP↓, Casp9↑, survivin↓, IAP1↓, Cyt‑c↑, Diablo↑, Bak↑, XIAP↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, Akt↓, eff↝, TumMeta↓,
7048- GA,    Natural bioactive gallic acid shows potential anticancer effects by inhibiting the proliferation and invasiveness behavior in human embryonic carcinoma cells
- in-vitro, Var, NA
AntiCan↑, TumCCA↑, angioG↓, TumCMig↓, TumMeta↓, CSCs↓, Apoptosis↑, P21↑, P53↑, p27/CDKN1B↑, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, SOX2↓, Nanog↓, OCT4↓, ROS↑, DNAdam↑, BRCA1↑, ATM↑, CHK1↑, Chk2↑, Histones↑, TumCI↓, MMPs↓, EGFR↓, JAK2↓, STAT5↓,
7029- GA,    Gallic acid induces G1 phase arrest and apoptosis of triple-negative breast cancer cell MDA-MB-231 via p38 mitogen-activated protein kinase/p21/p27 axis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, Nor, MCF10
AntiTum↑, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CDK2↓, P21↑, p27/CDKN1B↑, Casp9↑, Casp3↑, ROS↑, mtDam↑, i-Ca+2↑, *ROS↓, *Apoptosis↓, TumCG↓,
7091- GAR,    Garcinol-A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, Var, NA
antiOx↑, Inflam↓, HATs↓, p300↓, CBP↓, PCAF↓, cycD1/CCND1↓, STAT↓, PI3K↓, Akt↓, TumCP↓, TumCI↓, TumMeta↓, TumCCA↑, CDK2↓, CDK4↓,
804- GAR,    Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest
- in-vitro, EC, HEC1B - in-vitro, EC, ISH
TumCP↓, TumCCA↑, P53↑, P21↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycB/CCNB1↓, p‑cJun↑,
803- GAR,    Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↑, CDK6↑, P21↑, p27/CDKN1B↑, ERK↓, MAPK↓,
7284- Gins,  5-FU,    Ginsenoside Rg3 enhances the anticancer effect of 5-FU in colon cancer cells via the PI3K/AKT pathway
- vitro+vivo, CRC, SW-620 - in-vitro, CRC, LoVo
ChemoSen↑, TumCP↓, TumCI↓, TumCMig↓, APAF1↑, Casp9↑, Casp3↑, TumCCA↑, cycD1/CCND1↑, CDK2↑, CDK4↑, PI3K↓, Akt↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
2875- HNK,    Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, SCC, H226
HDAC↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, ac‑H3↑, ac‑H4↑, selectivity↑, CDK2↓, CDK4↓,
2865- HNK,    Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
- in-vitro, MB, DAOY - vitro+vivo, NA, NA
BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1/ATG6↑, ATG7↑, p62↑, Synergy↑, ChemoSen↑, *toxicity↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27/CDKN1B↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp/ABCB1↓,
7542- HT,    Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B - in-vitro, Nor, RWPE-1
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, CDK4↓, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, tumCV↓, Akt↓, STAT3↓, NF-kB↓, AR↓, ROS↑, mtDam↑, BioAv↓, toxicity↓, eff↑,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7655- IP,  SFN,    Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition
- in-vivo, BC, NA
Dose↝, TumCG↓, TumW↓, GutMicro↑, HDAC↓, DNMTs↓, Akt↓, PI3K↓, mTOR↓, NF-kB↓, TumCCA↑, cl‑Casp3↑, cl‑Casp7↑, CDK2↓, CDK4↓, Risk↓, Dose↝,

Showing Research Papers: 51 to 100 of 156
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 156

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↓, 1,   Catalase↑, 1,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 1,   GSH↓, 9,   GSH↑, 3,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 1,   GSTs↝, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 9,   hyperG↓, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 4,   MDA↓, 2,   MDA↑, 2,   MPO↓, 1,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 3,   NRF2↓, 3,   NRF2↑, 12,   Prx4↑, 1,   PYCR1↓, 1,   ROS↓, 10,   ROS↑, 68,   ROS⇅, 2,   i-ROS↓, 1,   i-ROS↑, 2,   mt-ROS↑, 1,   SOD↓, 5,   SOD↑, 3,   SOD1↑, 1,   SOD2↑, 3,   Trx↓, 1,   TrxR↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 8,   CDC25↓, 9,   compI↓, 3,   EGF↓, 2,   ETC↓, 1,   mitResp↓, 2,   mtDam↑, 11,   OCR↓, 1,   OCR↑, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ACC↑, 3,   ALAT↓, 3,   ALDOA↓, 1,   AMP↑, 1,   AMPK↓, 2,   AMPK↑, 11,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 7,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   ECAR↓, 2,   FASN↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 4,   Glycolysis↓, 9,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 3,   p‑GSK‐3β↑, 1,   H2S↑, 1,   Histones↑, 1,   HK1↓, 1,   HK2↓, 4,   IDO1↓, 1,   lactateProd↓, 2,   LDHA↓, 1,   LDL↓, 1,   NADPH↓, 2,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1↓, 2,   PKM2↓, 5,   SCD1↓, 1,   SIRT1↓, 2,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 4,   Apoptosis↓, 3,   Apoptosis↑, 63,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 5,   Bak↑, 4,   BAX↓, 2,   BAX↑, 48,   BAX⇅, 1,   Bax:Bcl2↑, 15,   Bcl-2↓, 49,   Bcl-xL↓, 12,   BID↓, 1,   BID↑, 5,   p‑BID↓, 1,   BIM↑, 5,   BNIP3↑, 2,   BOK↑, 2,   Casp↑, 13,   Casp1↓, 1,   Casp1↑, 1,   Casp10↓, 1,   Casp10∅, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 60,   cl‑Casp3↑, 10,   Casp7↑, 7,   cl‑Casp7↑, 5,   Casp8↓, 1,   Casp8↑, 19,   Casp8∅, 1,   cl‑Casp8↑, 3,   proCasp8↑, 1,   Casp9↑, 42,   cl‑Casp9↑, 6,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 44,   mt-Cyt‑c↓, 1,   Diablo↑, 11,   DR5↑, 12,   DR5∅, 1,   FADD↑, 4,   FADD∅, 1,   Fas↑, 14,   FasL↑, 1,   Ferroptosis↑, 2,   HEY1↓, 1,   IAP1↓, 3,   IAP1↑, 1,   IAP2/BIRC3↓, 3,   cl‑IAP2/BIRC3↑, 1,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 3,   Mcl-1↓, 12,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 6,   MDM2↑, 2,   NAIP↓, 2,   NOXA↑, 2,   p38↓, 3,   p38↑, 10,   p‑p38↓, 1,   PUMA↓, 1,   PUMA↑, 4,   survivin↓, 18,   TRAIL↑, 4,   TRAILR↑, 1,   TumCD↑, 6,   XIAP↓, 15,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 55,   Akt↑, 3,   p‑Akt↓, 14,   AKT1↓, 2,   Akt2↓, 1,   CK2↓, 5,   cMET↓, 2,   CREB↓, 1,   EF-1α↓, 1,   EGFR↓, 21,   p‑EGFR↓, 1,   ERK↓, 16,   ERK↑, 3,   p‑ERK↓, 4,   p‑ERK↑, 1,   FGFR1↓, 3,   FGFR2↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↓, 1,   IGF-1R↓, 1,   IKKα↓, 5,   p‑IKKα↓, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 7,   p‑JAK2↓, 1,   JNK↓, 3,   JNK↑, 10,   p‑JNK↓, 2,   p‑JNK↑, 1,   LIMK1↓, 1,   MAPK↓, 17,   MAPK↑, 7,   MARK4↓, 1,   MEK↓, 2,   mTOR↓, 28,   mTOR↑, 3,   mTOR↝, 1,   p‑mTOR↓, 5,   mTORC2↓, 3,   p70S6↓, 1,   P70S6K↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 47,   PI3K↑, 2,   p‑PI3K↓, 2,   PKA↓, 1,   PKCδ↓, 4,   PTEN↓, 1,   PTEN↑, 8,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 7,   p‑S6K↓, 1,   Sp1/3/4↓, 6,   Src↓, 1,   STAT↓, 2,   STAT3↓, 25,   p‑STAT3↓, 7,   p‑STAT3↑, 1,   STAT5↓, 1,   STAT6↓, 3,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AFAP1-AS1↓, 1,   ATF3↑, 1,   ATF4↓, 2,   ATF4↑, 7,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 7,   cJun↑, 2,   p‑cJun↑, 1,   cMyc↓, 24,   DNMT1↓, 1,   DNMTs↓, 3,   EZH2↓, 4,   FOXM1↓, 4,   FOXO↑, 2,   FOXO1↓, 1,   FOXO3↓, 2,   FOXO3↑, 2,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↑, 2,   p‑H3↓, 1,   ac‑H3↑, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 10,   HDAC1↓, 2,   HDAC10↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   KLF2↓, 1,   KLF5↓, 1,   miR-124-3p↓, 1,   miR-130a↓, 1,   miR-195↑, 1,   miR-200b↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 2,   miR-30a-5p↑, 1,   miR-34a↑, 5,   miR-545↑, 1,   MTA2↓, 1,   Myc↓, 2,   n-MYC↓, 1,   NDRG1↑, 1,   OCT4↓, 6,   other↑, 1,   other↝, 3,   PAX2↓, 1,   PCAF↓, 1,   SOX2↓, 5,   SOX4↓, 2,   SOX4↑, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV↓, 17,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 8,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 16,   GRP78/BiP↓, 1,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 3,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 7,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 8,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,   LC3II↑, 7,   LC3s↑, 1,   p62↓, 2,   p62↑, 2,   PARK2↑, 1,   TumAuto↓, 1,   TumAuto↑, 5,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 5,   ATR↑, 2,   BRCA1↓, 1,   BRCA1↑, 2,   p‑BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 25,   DNArepair↓, 1,   DNArepair↑, 1,   hTERT/TERT↓, 5,   p16↑, 3,   P53?, 1,   P53↓, 1,   P53↑, 48,   p‑P53↓, 1,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↓, 1,   PARP↑, 5,   cl‑PARP↑, 35,   PARP1↓, 1,   PARP1↑, 1,   PCNA↓, 13,   Telomerase↓, 8,   TOP1↓, 3,   TOP2↓, 4,   TOP2↑, 1,   TP53↑, 2,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK1↑, 1,   CDK2↓, 73,   CDK2↑, 3,   CDK4↓, 147,   CDK4↑, 8,   CDK4↝, 1,   CDK4∅, 1,   p‑CDK4↓, 1,   CDK6↓, 39,   CDK6↑, 8,   CDK6∅, 1,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 1,   CHK1↓, 1,   CHK1↑, 3,   Chk2↓, 1,   Chk2↑, 3,   cycA1/CCNA1↓, 10,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 17,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 106,   cycD1/CCND1↑, 1,   cycD1/CCND1∅, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 45,   cycE/CCNE↑, 3,   cycE1↓, 2,   E2F4↑, 1,   E2Fs↓, 5,   FBXO5/EMI1↓, 1,   Ki-67↓, 8,   mitA↓, 1,   P21?, 1,   P21↓, 2,   P21↑, 69,   p27/CDKN1B↓, 4,   p27/CDKN1B↑, 37,   pRB↓, 2,   pRB↑, 2,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 4,   p‑RB1↓, 7,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 4,   TumCCA↑, 115,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   ALDH1A1↓, 2,   BMPs↑, 1,   CD133↓, 4,   CD133↑, 1,   cFos↓, 8,   CSCs↓, 15,   Diff↓, 1,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 1,   HH↓, 3,   IGF-1↓, 6,   IGFBP3↑, 2,   Ki-67↓, 8,   Let-7↑, 2,   mTORC1↓, 6,   p‑mTORC1↓, 1,   Nanog↓, 6,   Nestin↓, 2,   NOTCH↓, 7,   NOTCH1↓, 4,   NOTCH3↓, 1,   p300↓, 1,   PTCH1↓, 1,   Shh↓, 2,   STAT1↓, 1,   TumCG↓, 27,   TumCG↑, 1,   TumCP↓, 62,   TumCP↑, 1,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt↓, 15,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 10,   ATPase↓, 2,   AXL↓, 2,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 17,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↑, 1,   Cdc42↑, 1,   Cofilin↓, 1,   DLC1↑, 1,   E-cadherin↓, 4,   E-cadherin↑, 22,   EMT↓, 30,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 1,   Fibronectin↓, 2,   GIT1↓, 1,   ITGA5↓, 1,   ITGB4↓, 1,   KRAS↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP1↓, 3,   MMP13↓, 2,   MMP2↓, 42,   MMP3↓, 3,   MMP7↓, 8,   MMP9↓, 49,   MMP9↑, 1,   MMPs↓, 11,   N-cadherin↓, 11,   PAK1↑, 1,   PDGF↓, 5,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Slug↓, 7,   Smad1↑, 1,   Snail?, 1,   Snail↓, 9,   TET1↓, 1,   TGF-β↓, 5,   TIMP1↑, 3,   TIMP2↑, 2,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 27,   TumCI↑, 1,   TumCMig↓, 32,   TumCMig↑, 1,   TumMeta↓, 29,   TumMeta↑, 2,   Twist↓, 10,   uPA↓, 17,   uPAR↓, 1,   Vim↓, 17,   Zeb1↓, 10,   ZEB2↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 19,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 35,   angioG↑, 1,   eNOS↓, 1,   HIF-1↓, 2,   Hif1a↓, 22,   LOX1↓, 1,   NO↓, 2,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 45,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   EPR↑, 1,   GLUT1↓, 3,   GLUT1↑, 1,   GLUT3↑, 1,   MMP↓, 43,   MPT↑, 1,   NHE1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↑, 1,   CD44↓, 4,   CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 39,   CXCL1↓, 1,   CXCR4↓, 6,   DR4↑, 3,   DR4∅, 1,   FOXP3↓, 2,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 1,   IL1↓, 4,   IL10↓, 1,   IL10↑, 1,   IL12↓, 3,   IL1α↓, 1,   IL1β↓, 6,   IL2↓, 2,   IL2↑, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 16,   IL6↑, 1,   IL8↓, 7,   Imm↑, 2,   Inflam↓, 10,   IRAK1↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MIP2↓, 1,   NF-kB↓, 61,   NF-kB↑, 2,   p‑NF-kB↓, 1,   NK cell↑, 2,   NLRP3↓, 1,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-L1↓, 3,   PD-L1↑, 1,   PGE2↓, 13,   PSA↓, 9,   PSA∅, 1,   T-Cell↑, 1,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 13,   TNF-α↑, 2,   TRADD↑, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 1,   AR↓, 9,   ER-α36↓, 2,   GR↑, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 4,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 18,   BioAv↑, 16,   BioAv↝, 2,   BioEnh↑, 4,   ChemoSen↓, 1,   ChemoSen↑, 55,   CompStab↑, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1B1↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 5,   Dose↝, 17,   Dose∅, 2,   eff↓, 9,   eff↑, 25,   eff↝, 9,   eff∅, 1,   Half-Life↓, 7,   Half-Life↝, 6,   MDR1↓, 1,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 10,   P450↓, 1,   P450↝, 1,   RadioS↑, 16,   selectivity?, 1,   selectivity↑, 37,   Synergy↑, 54,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 3,   ALP↓, 1,   AR↓, 9,   ascitic↓, 1,   AST↓, 2,   BG↓, 1,   BRCA1↓, 1,   BRCA1↑, 2,   p‑BRCA1↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 21,   p‑EGFR↓, 1,   EZH2↓, 4,   Ferritin↓, 2,   FOXM1↓, 4,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 5,   IL6↓, 16,   IL6↑, 1,   KRAS↓, 1,   LDH↓, 1,   Myc↓, 2,   PD-L1↓, 3,   PD-L1↑, 1,   PSA↓, 9,   PSA∅, 1,   TP53↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 20,   AntiTum↑, 4,   cachexia↓, 1,   cardioP↑, 4,   CardioT↓, 1,   chemoP↑, 7,   chemoPv↑, 7,   ChemoSideEff↓, 3,   hepatoP↑, 4,   neuroP↑, 4,   NP/CIPN↓, 2,   OS↑, 5,   PFS↑, 1,   QoL↑, 2,   radioP↑, 2,   RenoP↑, 3,   Risk↓, 3,   toxicity↓, 6,   toxicity↑, 2,   toxicity↝, 2,   toxicity∅, 2,   TumVol↓, 8,   TumW↓, 5,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 706

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 29,   Catalase↑, 13,   GPx↓, 1,   GPx↑, 8,   GSH↑, 12,   GSR↑, 3,   GSTs↑, 3,   H2O2↓, 1,   HDL↓, 1,   HDL↑, 2,   HO-1↑, 9,   Keap1↑, 1,   lipid-P↓, 10,   MDA↓, 8,   MPO↓, 2,   NQO1↑, 3,   Nrf1↑, 1,   NRF2↑, 13,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 25,   SOD↓, 1,   SOD↑, 13,   SOD1↑, 1,   SOD2↑, 1,   Trx↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↓, 1,   ALAT↓, 6,   AMPK↑, 3,   p‑AMPK↑, 1,   ATP↑, 1,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GSK‐3β↓, 2,   LDHA↑, 1,   LDL↓, 4,   lipidLev↓, 2,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↓, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 1,   cl‑Casp8↑, 1,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 6,   necrosis↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   Akt2↓, 1,   CREB↑, 1,   ERK↓, 2,   ERK↑, 2,   IKKα↓, 1,   p‑JNK↓, 1,   MAPK↓, 3,   MAPK↑, 1,   mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 1,   PKCδ↓, 1,   PTEN↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 1,   p‑cMyc↑, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP27↓, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSPs↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   p16↓, 1,   P53↓, 1,   PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   Ki-67↓, 1,   P21↓, 1,   P21↑, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   IGF-1↑, 1,   Ki-67↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   Ca+2↓, 1,   Ca+2↝, 1,   MLC2/MYL9↝, 1,   MMP2↑, 1,   MMP9↓, 2,   Rho↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TIMP1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   NO↓, 1,   VCAM-1↓, 2,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 2,   MMP↑, 2,   OCLN↝, 1,   TJ↑, 1,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 9,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 2,   IL10↑, 1,   IL17↓, 2,   IL1β↓, 6,   IL22↓, 1,   IL23↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 8,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 28,   LPS↓, 1,   MCP1/CCL2↓, 2,   NF-kB↓, 12,   NLRP3↓, 2,   PGE2↓, 4,   RAGE↓, 1,   SOCS-3↓, 1,   TLR4↓, 2,   TNF-α↓, 11,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 2,   BDNF↑, 1,   GABA↑, 2,   MAOA↓, 1,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 6,   BACE/β-secretase↓, 2,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 13,   BioAv↑, 5,   BioAv↝, 3,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↑, 1,   Dose↝, 4,   eff↑, 1,   Half-Life↑, 1,   Half-Life∅, 1,   P450↓, 1,   P450↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 1,   AST↓, 6,   BMD↑, 1,   BP↓, 3,   creat↓, 1,   CRP↓, 2,   HOMA↓, 1,   hs-CRP↓, 2,   IL6↓, 8,   LDH↓, 2,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 6,   AntiArt↑, 3,   AntiCan↑, 7,   AntiDiabetic↑, 6,   antiPs↑, 1,   cardioP↑, 12,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 4,   hepatoP↑, 10,   Learn↑, 1,   memory↑, 7,   motorD↑, 1,   neuroP↑, 22,   Obesity↓, 4,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   Stroke↓, 3,   toxicity↓, 6,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   AntiViral↑, 2,   Bacteria↓, 4,   GutMicro↑, 7,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 239

Scientific Paper Hit Count for: CDK4, Cyclin-dependent kinase 4
14 Fisetin
7 Ferulic acid
6 Honokiol
4 Artemisinin
4 Baicalein
4 Berberine
4 Boswellia (frankincense)
4 Capsaicin
4 Sulforaphane (mainly Broccoli)
4 Lycopene
4 Silymarin (Milk Thistle) silibinin
3 Propolis -bee glue
3 Carvacrol
3 Chrysin
3 Diindolylmethane
3 Garcinol
3 Luteolin
3 Magnolol
3 Thymoquinone
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Curcumin
2 Chemotherapy
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Indole-3-carbinol
2 Ellagic acid
2 Flaxseed/Linseed
2 Gallic acid
2 HydroxyTyrosol
2 phytic acid, Inositol hexakisphosphate
2 Kaempferol
2 lambertianic acid
2 Morin
2 Piperlongumine
2 Resveratrol
2 Shikonin
1 Silver-NanoParticles
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Astaxanthin
1 Radiotherapy/Radiation
1 Biochanin A
1 Betulinic acid
1 Bufalin/Huachansu
1 Boron
1 Cisplatin
1 Caffeic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Thymol-Thymus vulgaris
1 Cinnamon
1 Hydroxycinnamic-acid
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Deguelin
1 diet FMD Fasting Mimicking Diet
1 EGCG (Epigallocatechin Gallate)
1 Eugenol
1 Formononetin
1 Fucoidan
1 Ginseng
1 5-fluorouracil
1 Hydrogen Gas
1 Inulin Prebiotic
1 isoorientin
1 Ivermectin
1 Juglone
1 Licochalcone A
1 Licorice
1 Linalool
1 Matrine
1 Metformin
1 Melatonin
1 Lemon Balm/Melissa officinalis
1 doxorubicin
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Orlistat
1 Pterostilbene
1 Quercetin
1 Rosmarinic acid
1 Aflavin-3,3′-digallate
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:894  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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