CDK6 Cancer Research Results

CDK6, Cyclin-dependent kinase 6: Click to Expand ⟱
Source:
Type:
Cyclin-dependent kinase 6 (CDK6) is another important regulator of the cell cycle, particularly involved in the transition from the G1 phase to the S phase.
CDK6 is frequently overexpressed in various cancers, and its expression levels can serve as a prognostic marker. Targeting CDK6 with specific inhibitors, such as palbociclib (which also targets CDK4), has shown promise in clinical settings, particularly in hormone receptor-positive breast cancer.


Scientific Papers found: Click to Expand⟱
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3376- QC,    Inhibiting CDK6 Activity by Quercetin Is an Attractive Strategy for Cancer Therapy
- in-vitro, BC, MCF7 - in-vitro, Lung, A549
CDK6↓, tumCV↓, Apoptosis↑, ROS↓, ChemoSen↑, *Synergy↑,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *chemoPv↑, ChemoSen↑, BioAv↑, Half-Life↝, COX2/PTGS2↓, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, P21↑, MMP9↓, NF-kB↓, Telomerase↓, PSA↓, MAPK↑, P53↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,

Showing Research Papers: 51 to 57 of 57
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 57

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   Catalase↓, 1,   GPx↓, 1,   GSH↓, 3,   GSH↑, 1,   GSTs↑, 2,   HO-1↓, 3,   HO-1↑, 3,   HO-2↓, 1,   hyperG↓, 1,   Keap1↓, 1,   lipid-P↑, 2,   MDA↑, 1,   MPO↓, 1,   NADH↓, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 3,   Prx4↑, 1,   PYCR1↓, 1,   ROS↓, 5,   ROS↑, 28,   ROS⇅, 1,   SOD↓, 3,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 2,   Trx↓, 1,   TrxR↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 3,   CDC25↑, 1,   compI↓, 2,   HSP60/HSPD1↑, 1,   mitResp↓, 1,   mtDam↑, 4,   OCR↓, 2,   OCR↑, 1,   PDH↝, 1,   PGC-1α↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ALAT↓, 2,   AMP↑, 1,   AMPK↑, 6,   ATP↓, 3,   CAIX/CA9↓, 1,   ECAR↓, 1,   ECAR↝, 1,   glucoNG↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 5,   GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HK2↓, 2,   lactateProd↓, 2,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PKM2↓, 2,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   Apoptosis↑, 26,   ASK1↑, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 21,   BAX⇅, 1,   Bax:Bcl2↑, 5,   Bcl-2↓, 21,   Bcl-xL↓, 4,   BID↓, 1,   BID↑, 2,   BIM↑, 3,   Casp↑, 5,   Casp1↑, 1,   Casp10↓, 1,   Casp10∅, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 27,   cl‑Casp3↑, 2,   CASP4↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 9,   Casp8∅, 1,   proCasp8↑, 1,   Casp9↑, 18,   cl‑Casp9↑, 1,   cFLIP↓, 2,   Cyt‑c↑, 18,   Diablo↑, 6,   DR5↑, 4,   DR5∅, 1,   FADD↑, 1,   FADD∅, 1,   Fas↑, 8,   Ferroptosis↑, 1,   HEY1↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   ICD↑, 1,   iNOS↓, 4,   Mcl-1↓, 7,   MDM2↓, 2,   MDM2↑, 1,   NOXA↑, 3,   p38↑, 5,   PUMA↑, 4,   survivin↓, 9,   TRAIL↑, 1,   TumCD↑, 2,   XIAP↓, 9,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 22,   Akt↑, 3,   p‑Akt↓, 6,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   EGFR↓, 5,   ERK↓, 5,   ERK↑, 2,   p‑ERK↓, 2,   FGFR1↓, 3,   FGFR2↓, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   Hippo↓, 1,   IKKα↓, 2,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 4,   JNK↓, 1,   JNK↑, 7,   LIMK1↓, 1,   MAPK↓, 5,   MAPK↑, 4,   mTOR↓, 12,   mTOR↑, 3,   p‑mTOR↓, 1,   p70S6↓, 1,   P70S6K↓, 1,   PI3K↓, 18,   PI3K↑, 2,   p‑PI3K↓, 1,   PKA↓, 1,   PKCδ↓, 3,   PTEN↑, 5,   RAS↓, 2,   Sp1/3/4↓, 4,   STAT3↓, 10,   p‑STAT3↓, 3,   STAT6↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 3,   ATF4↝, 1,   cJun↓, 2,   cMyc↓, 10,   DNMT1↓, 1,   DNMTs↓, 2,   EZH2↓, 2,   FOXM1↓, 1,   FOXO↑, 2,   FOXO3↑, 1,   p‑FOXO3↓, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 3,   HDAC1↓, 2,   HDAC3↓, 1,   KLF2↓, 1,   KLF5↓, 1,   miR-124-3p↓, 1,   miR-130a↓, 1,   miR-200b↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 2,   miR-34a↑, 3,   Myc↓, 2,   NDRG1↑, 1,   OCT4↓, 2,   SOX2↓, 1,   SOX4↑, 1,   TCF-4↓, 1,   TFE3↑, 1,   tumCV↓, 8,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↓, 1,   p‑eIF2α↑, 1,   ER Stress↑, 9,   GRP78/BiP↑, 4,   HSF1↓, 1,   HSP27↓, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 2,   IRE1↑, 2,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,   LC3II↑, 4,   p62↓, 1,   p62↑, 1,   PARK2↑, 1,   TumAuto↑, 4,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   ATR↑, 2,   BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↓, 1,   DNAdam↑, 10,   p16↑, 2,   P53?, 1,   P53↑, 21,   p‑P53↑, 1,   PARP↑, 5,   cl‑PARP↑, 16,   PARP1↓, 1,   PARP1↑, 1,   PCNA↓, 4,   SIRT6↑, 1,   Telomerase↓, 4,   TOP1↓, 1,   TOP2↓, 2,   TP53↑, 2,   UHRF1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CDK1↓, 3,   CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 26,   CDK2↑, 3,   CDK4↓, 41,   CDK4↑, 5,   CDK4∅, 1,   CDK6↓, 50,   CDK6↑, 9,   CDK6∅, 1,   CDK8↓, 1,   CDKN2C/p18↑, 1,   CHK1↑, 1,   Chk2↑, 1,   cycA1/CCNA1↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 40,   cycD1/CCND1∅, 1,   CycD3↓, 4,   cycE/CCNE↓, 20,   cycE/CCNE↑, 1,   cycE1↓, 1,   cycF↑, 1,   E2F4↑, 1,   E2Fs↓, 1,   GADD45A↑, 1,   Ki-67↓, 6,   MAD↓, 1,   mitA↓, 1,   P21↓, 1,   P21↑, 25,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 14,   pRB↓, 2,   pRB↑, 2,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 2,   cl‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 38,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   cFos↓, 3,   CSCs↓, 5,   Diff↑, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 1,   HH↓, 2,   IGF-1↓, 3,   Ki-67↓, 6,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 2,   NOTCH↓, 4,   NOTCH1↓, 1,   NOTCH3↓, 1,   Shh↓, 1,   STAT1↓, 1,   TumCG↓, 10,   TumCP↓, 20,   TumCP↑, 1,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt↓, 4,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AP-1↓, 5,   ATPase↓, 1,   AXL↓, 1,   Ca+2↑, 10,   Ca+2↝, 1,   CAFs/TAFs↓, 1,   Cofilin↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 11,   EMT↓, 11,   FAK↓, 2,   p‑FAK↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP2↓, 17,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 21,   MMPs↓, 2,   N-cadherin↓, 5,   NEDD9↓, 1,   PAK1↑, 1,   PDGF↓, 2,   Rho↑, 1,   ROCK1↑, 1,   Slug↓, 3,   SMAD3↓, 2,   Snail?, 1,   Snail↓, 7,   TGF-β↓, 6,   TGF-β↑, 1,   TIMP1↑, 2,   TIMP2↑, 1,   TSP-1↑, 2,   TumCI↓, 12,   TumCI↑, 1,   TumCMig↓, 12,   TumCMig↑, 1,   TumMeta↓, 10,   Twist↓, 9,   uPA↓, 6,   Vim↓, 11,   Zeb1↓, 3,   ZEB2↓, 1,   β-catenin/ZEB1↓, 11,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 16,   angioG↑, 1,   Endoglin↑, 1,   HIF-1↓, 1,   Hif1a↓, 11,   NO↓, 2,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 19,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

CLDN2↓, 1,   GLUT1↓, 3,   MMP↓, 15,   NHE1↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   CD47↓, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 16,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 5,   DR4↑, 2,   DR4∅, 1,   DR6↑, 1,   ICAM-1↓, 1,   IL1↓, 1,   IL10↓, 2,   IL12↓, 2,   IL1β↓, 2,   IL2↑, 1,   IL4↓, 1,   IL6↓, 8,   IL8↓, 4,   Imm↑, 1,   Inflam↓, 3,   M2 MC↓, 1,   NF-kB↓, 20,   NF-kB↑, 1,   NK cell↑, 1,   p50↓, 1,   p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 3,   PSA↓, 2,   TCF↝, 1,   TNF-α↓, 4,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 1,   ER-α36↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 5,   BioEnh↑, 2,   ChemoSen↑, 24,   CYP1B1↑, 1,   Dose↝, 7,   Dose∅, 2,   eff↓, 5,   eff↑, 14,   eff↝, 3,   eff∅, 1,   Half-Life↝, 3,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   RadioS↑, 13,   selectivity↑, 12,   Synergy↑, 23,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AR↓, 1,   AST↓, 2,   BG↓, 1,   BRCA1↑, 1,   EGFR↓, 5,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   IL6↓, 8,   LDH↓, 2,   Myc↓, 2,   PD-L1↓, 1,   PSA↓, 2,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 4,   ChemoSideEff↓, 2,   hepatoP↑, 1,   NP/CIPN↓, 2,   PFS↑, 1,   QoL↑, 1,   radioP↑, 1,   Risk↓, 1,   toxicity↓, 2,   TumVol↓, 3,   TumW↓, 2,  
Total Targets: 471

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 8,   Catalase↑, 3,   GPx↓, 1,   GPx↑, 2,   GSH↑, 4,   HDL↓, 1,   HO-1↑, 3,   Keap1↑, 1,   lipid-P↓, 2,   MDA↓, 3,   MPO↓, 2,   NRF2↑, 6,   ROS?, 1,   ROS↓, 4,   SOD↑, 2,   SOD1↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 1,   ATP↑, 1,   GSK‐3β↓, 1,   LDL↓, 2,  

Cell Death(tgid=5) ⓘ

Casp12↓, 1,   Casp3↓, 1,   GranB/GZMB↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   ERK↓, 1,   ERK↑, 1,   p‑JNK↓, 1,   mTOR↓, 1,   PI3K↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   p‑cMyc↑, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   MMP9↓, 2,   Rho↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   IBI↑, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL10↓, 1,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 3,   IL23↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 4,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 7,   LPS↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 3,   NLRP3↓, 1,   PGE2↓, 1,   TLR4↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 3,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↝, 1,   Dose↝, 2,   eff↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   creat↓, 1,   IL6↓, 4,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiArt↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 2,   antiPs↑, 1,   cardioP↑, 2,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 4,   memory↑, 1,   neuroP↑, 4,   Obesity↓, 2,   RenoP↑, 1,   Stroke↓, 1,   toxicity∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 3,   Sepsis↓, 2,  
Total Targets: 117

Scientific Paper Hit Count for: CDK6, Cyclin-dependent kinase 6
7 Ferulic acid
5 Ellagic acid
4 Fisetin
2 Allicin (mainly Garlic)
2 Artemisinin
2 Berberine
2 Boswellia (frankincense)
2 Chemotherapy
2 Propolis -bee glue
2 Capsaicin
2 Indole-3-carbinol
2 Piperlongumine
2 Quercetin
1 Apigenin (mainly Parsley)
1 Boron
1 Curcumin
1 Caffeic acid
1 Carvacrol
1 Celastrol
1 diet FMD Fasting Mimicking Diet
1 EGCG (Epigallocatechin Gallate)
1 Garcinol
1 Ginkgolic acids
1 Hydrogen Gas
1 Honokiol
1 phytic acid, Inositol hexakisphosphate
1 Ivermectin
1 Kaempferol
1 lambertianic acid
1 Luteolin
1 Lutein
1 Metformin
1 Lemon Balm/Melissa officinalis
1 Nimbolide
1 Phenethyl isothiocyanate
1 Resveratrol
1 Sulforaphane (mainly Broccoli)
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:895  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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