TumW Cancer Research Results

TumW, Tumor Weight: Click to Expand ⟱
Source:
Type:
Tumor Weight
Scientific Papers found: Click to Expand⟱
2081- HNK,    Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, SW48 - in-vitro, Colon, HT-29 - in-vitro, Colon, LS174T - in-vitro, Colon, HCT8 - in-vitro, Colon, SW480 - in-vivo, NA, NA
tumCV↓, ROS↑, Iron↑, GPx4↓, mtDam↑, Ferroptosis↑, TumVol↓, TumW↓,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
7569- HYP,    Inhibitory effects of hyperoside on lung cancer by inducing apoptosis and suppressing inflammatory response via caspase-3 and NF-κB signaling pathway
- vitro+vivo, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, Casp3↑, Apoptosis↑, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL18↓, TumVol↓, TumW↓,
7590- I3C,    Indole-3-carbinol synergistically sensitises ovarian cancer Indole-3-carbinol synergistically sensitises ovarian cancer cells to bortezomib treatmentcells to bortezomib treatment
- in-vivo, Ovarian, NA
ChemoSen↑, TumCG↓, TumW↓,
7776- IBC,    Isobavachalcone Activates Antitumor Immunity on Orthotopic Pancreatic Cancer Model: A Screening and Validation
- vitro+vivo, PC, Panc02
TumCP↓, Apoptosis↑, ROS↑, TumW↓, CD8+↑, M2 MC↓, CSCs↓, antiNeop↑, Imm↑, eff↓, Bcl-2↓, BAX↑,
7655- IP,  SFN,    Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition
- in-vivo, BC, NA
Dose↝, TumCG↓, TumW↓, GutMicro↑, HDAC↓, DNMTs↓, Akt↓, PI3K↓, mTOR↓, NF-kB↓, TumCCA↑, cl‑Casp3↑, cl‑Casp7↑, CDK2↓, CDK4↓, Risk↓, Dose↝,
7697- IP6,  Ins,    Combination of Inositol Hexaphosphate and Inositol Inhibits Liver Metastasis of Colorectal Cancer in Mice Through the Wnt/β-Catenin Pathway
- in-vivo, CRC, NA
TumMeta↓, OS↑, TumW↓, Wnt↓, TCF7/TCF1↓, cMyc↓,
7691- IP6,    Inositol Hexaphosphate Suppresses Growth and Induces Apoptosis in Prostate Carcinoma Cells in Culture and Nude Mouse Xenograft: PI3K-Akt Pathway as Potential Target
- vitro+vivo, Pca, PC3 - in-vitro, Pca, C4-2B
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, Akt↓, PI3K↓, p‑GSK‐3β↓, cycD1/CCND1↓, TumVol↓, TumW↓, PCNA↓, angioG↓, CD31/PECAM-1↓, ILK↓, VEGF↓, eNOS↓, Hif1a↓,
7699- IP6,    IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise
- Review, Var, NA
*Iron∅, ChemoSen↑, *cardioP↑, neuroP↑, IronCh∅, P21↓, p27/CDKN1B↓, p‑pRB↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TumW↓, TumCI↓, TumMeta↓, Imm↑, Diff↑, selectivity↑, toxicity↓, RenoP↑, QoL↑,
7702- IP6,  Ins,  capec,    Inositol Hexakisphosphate and Inositol Enhance the Inhibition of Colorectal Cancer Growth and Liver Metastasis by Capecitabine in a Mouse Model
- in-vivo, CRC, NA
Dose↝, AntiTum↑, OS↑, TumW↓, TumMeta↓, E-cadherin↑, N-cadherin↓, Vim↓, TNF-α↓, IL6↓, IL8↓, ChemoSen↑,
8042- IVM,    Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug
- vitro+vivo, Var, NA
Dose↝, TumCD↑, eff↓, TumCCA↑, ChemoSen↑, tumCV↓, TumVol↓, TumW↓,
7892- IVT,    Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway
- in-vitro, Nor, HCEC 1CT - in-vivo, Colon, NA
TumCP↓, selectivity↑, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑, TumVol↓, TumW↓,
8074- KAE,    Dose-dependent tuning of HSP70-Beclin-1 by kaempferol governs autophagy and chemosensitivity
- in-vitro, SCC, KYSE150 - in-vitro, SCC, KYSE450 - in-vitro, CRC, HCT116 - in-vitro, Liver, HepG2 - in-vitro, Cerv, HeLa - in-vitro, Lung, A549
ChemoSen⇅, HSP70/HSPA5↑, Beclin-1/ATG6⇅, Dose↝, TumVol⇅, TumW⇅,
8233- LCA,    Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer
- in-vitro, Lung, NA
TumCP↓, selectivity↑, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, BAX↑, PARP1↑, Casp3↑, Bcl-2↓, MAPK↓, FBXO5/EMI1↓, TumVol↓, TumW↓, toxicity↓,
8335- LDN,    The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice
- vitro+vivo, Ovarian, SKOV3
OGF↑, OGFr↑, Dose↝, TumW↓, TumNum?, TumCP↓, angioG↓, toxicity↓,
8322- LIN,  doxoR,    Effect of linalool as a component of Humulus lupulus on doxorubicin-induced antitumor activity
- vitro+vivo, Var, NA
ChemoSen↑, TumW↓, Na+↝,
6483- LIN,    Linalool-Incorporated Nanoparticles as a Novel Anticancer Agent for Epithelial Ovarian Carcinoma
- in-vitro, Ovarian, A2780S
Apoptosis↑, ROS↑, MMP↓, Casp3↑, TumW↓, ChemoSen↑, EPR↑,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
1041- Lyco,  immuno,    Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells
- in-vivo, Lung, NA
TumVol↓, TumW↓, eff↑, IL1↑, IFN-γ↑, IL4↓, IL10↓,
8509- MAG,  Rad,    The In Vivo Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma
- in-vivo, HCC, NA
TumVol↓, TumW↓, *ERK↓, *NF-kB↓, Casp3↑, Casp9↑, RadioS↑, *toxicity↓, Ki-67↓, IL1β↓, TNF-α↓,
8557- Matr,    Effects of matrine in combination with cisplatin on liver cancer
- in-vivo, Liver, HepG2
ChemoSen?, TumW↓, TumVol↓, survivin↓, XIAP↓, Casp3↑, Casp7↑, Casp9↑,
8642- MBZ,    In vitro and in vivo anticancer activity of mebendazole in colon cancer: a promising drug repositioning
- vitro+vivo, CRC, HT-29 - NA, NA, MCF10
Dose↝, selectivity↑, Apoptosis↑, TumVol↓, TumW↓, OS↑, TumCP↓,
8816- MCP,    Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, 4T1
GlucoseCon↓, GLUT1↓, Gal-3↓, ROS↓, NRF2↓, Hif1a↓, angioG↓, pol-M2 MC↓, p‑STAT3↓, TumCG↓, TumW↓,
8750- MeSA,    Methylseleninic acid restricts tumor growth in nude mice model of metastatic breast cancer probably via inhibiting angiopoietin-2
- vitro+vivo, BC, MDA-MB-231
ANGPT2↓, VEGF↓, TumVol↓, TumW↓,
9075- MGF,    Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and β-catenin signaling pathway
- vitro+vivo, BC, MDA-MB-231
tumCV↓, TumMeta↓, MMP7↓, MMP9↓, EMT↓, β-catenin/ZEB1↓, TumVol↓, TumW↓, TumCP↓, Apoptosis↑, Vim↓, E-cadherin↑,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
8683- MLT,    Intra-tumor ROS amplification by melatonin interferes in the apoptosis-autophagy-inflammation-EMT collusion in the breast tumor microenvironment
- in-vivo, BC, NA
ROS↑, SIRT1↑, IL6↓, STAT3↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, tumCV↓, JNK↑, P53↑, Bax:Bcl2↑, cl‑Casp3↑, Apoptosis↑, eff∅, TumAuto↑, EMT↓, Half-Life↓, CompStab↓, BioAv↓, Dose↝, TumW↓, TumVol↓, Ki-67↓, PTEN↑,
8951- mushLions,    Apoptotic mechanisms of gastric cancer cells induced by isolated erinacine S through epigenetic histone H3 methylation of FasL and TRAIL
- vitro+vivo, GC, NA
Apoptosis↑, ROS↑, selectivity↑, TumCG↓, FasL↑, TRAIL↑, PCNA↓, cycD1/CCND1↓, Casp3↑, Casp9↑, Casp8↑, Bcl-2↓, Bcl-xL↓, TumCCA↑, tumCV↓, TumVol↓, TumW↓,
8967- mushLions,    Recent developments in mushrooms as anti-cancer therapeutics: a review
- Review, Var, NA
ChemoSen↑, cFLIP↓, JNK↑, NF-kB↓, TumW↓, VEGF↓, COX2/PTGS2↓, 5LO↓, angioG↓, Ingr↝,
1805- NarG,    Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota
- in-vitro, Ovarian, A2780S - in-vivo, NA, NA
TumCP↓, TumCMig↓, PI3K↓, TumVol↓, TumW↓, BioAv↑, GutMicro↑, Dose∅, eff↑, EGFR↓, cycD1/CCND1↓, toxicity∅,
1670- PBG,    Lung response to propolis treatment during experimentally induced lung adenocarcinoma
- in-vivo, Lung, NA
GSH↑, SOD↑, MDA↓, selectivity↑, Inflam↓, TumW↓,
4928- PEITC,    Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers
- vitro+vivo, Colon, SW-620
Risk↓, HDAC↓, TumW↓, TumCG↓, AP-1↓, cAMP↓, NF-kB↓, BMI1↓, SUZ12↓, EZH2↓, selectivity↑,
9016- Phyco,    Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy
- vitro+vivo, PC, PANC1 - in-vitro, PC, Capan1 - in-vitro, Liver, HepG2 - in-vitro, Lung, H460 - in-vitro, Pca, DU145
TumCP↓, TumCCA↑, Beclin-1/ATG6↑, p38↑, JNK↑, ERK↓, PI3K↓, Akt↓, mTOR↓, selectivity↑, Dose↝, toxicity↓, TumW↓, TumVol↓, TumAuto↑,
2944- PL,    Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells
- in-vitro, Thyroid, IHH4 - in-vitro, Thyroid, 8505C - in-vivo, NA, NA
ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
1238- PTS,    Pterostilbene suppresses gastric cancer proliferation and metastasis by inhibiting oncogenic JAK2/STAT3 signaling: In vitro and in vivo therapeutic intervention
- in-vitro, GC, NA - in-vivo, NA, NA
TumCCA↑, TumCP↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, Weight∅, JAK2↓, STAT3↓,
880- RES,    Forkhead Proteins Are Critical for Bone Morphogenetic Protein-2 Regulation and Anti-tumor Activity of Resveratrol
- in-vitro, BC, MDA-MB-231
other↓, TumW↓, FOXO↑, BMP2↑,
9278- SES, SSM,    Antitumor Effects of Sesamin via the LincRNA-p21/STAT3 Axis in Human Bladder Cancer: Inhibition of Metastatic Progression and Enhanced Chemosensitivity
- vitro+vivo, Bladder, UMUC3 - in-vitro, Bladder, 5637
tumCV↓, MMP2↓, STAT3↓, TumCMig↓, TumCI↓, ChemoSen↑, TumVol↓, TumW↓, Ki-67↓, Synergy↑,
1458- SFN,    Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
- Review, Bladder, NA
HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2/PTGS2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,
1483- SFN,    Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment
- in-vitro, OS, 143B - in-vitro, Nor, HEK293 - in-vivo, OS, NA
AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,
2192- SK,    Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation
- in-vitro, ESCC, KYSE-510 - in-vitro, ESCC, Eca109 - in-vivo, NA, NA
TumCP↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, p‑PKM2↓, p‑STAT3↓, GLUT1↓, HK2↓, TumW↓,
2185- SK,    Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis
- in-vitro, Lung, LLC1 - in-vitro, Melanoma, B16-BL6 - in-vivo, NA, NA
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, selectivity↑, Warburg↓, TumVol↓, TumW↓,
2182- SK,  Cisplatin,    Shikonin inhibited glycolysis and sensitized cisplatin treatment in non-small cell lung cancer cells via the exosomal pyruvate kinase M2 pathway
- in-vitro, Lung, A549 - in-vitro, Lung, PC9 - in-vivo, NA, NA
tumCV↓, TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, PKM2↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, ChemoSen↑, TumVol↓, TumW↓, GLUT1↓,
1018- SSE,    Selenite-induced autophagy antagonizes apoptosis in colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, HCT116 - vitro+vivo, CRC, SW480
TumAuto↑, LC3s↑, TumW↓, Weight∅, Beclin-1/ATG6↑, p62↓, ROS↑,
6433- T4O,  CET,    Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers
- in-vitro, Colon, HT29 - in-vitro, CRC, HCT116 - in-vitro, PC, COLO357 - Human, Colon, NA
TumCG↓, Synergy↑, ChemoSen↑, Apoptosis↑, TumVol↓, TumW↓, *Inflam↓, *antiOx↓, BioAv↝,
5332- TFdiG,    Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,
9151- WN,    Antioxidant and Anti-Inflammatory Properties of Walnut Constituents: Focus on Personalized Cancer Prevention and the Microbiome
- Review, Var, NA - Review, Col, NA
Ingr↝, GutMicro↑, Inflam↓, Imm↑, *cardioP↑, *AntiDiabetic↑, *AntiAge↑, Risk↓, Ingr↝, RANTES↓, eff↑, IL10↓, TumW↓, Risk↓, Risk↓,

Showing Research Papers: 51 to 97 of 97
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 97

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

DJ-1↓, 1,   GPx4↓, 2,   GSH↓, 5,   GSH↑, 1,   H2O2↑, 1,   HO-1↑, 1,   Iron↑, 3,   Iron∅, 1,   i-Iron↑, 1,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 4,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 2,   PYCR1↓, 1,   ROS↓, 3,   ROS↑, 24,   mt-ROS↑, 2,   SOD↓, 1,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 1,   TrxR↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh∅, 1,   NCOA4↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,   OCR↑, 1,   OXPHOS↑, 2,   PDH↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   Alanine↓, 1,   p‑AMPK↑, 1,   ARG↓, 1,   ATP↓, 3,   CAIX/CA9↓, 1,   cAMP↓, 1,   ECAR↓, 1,   GlucoseCon↓, 4,   Glycine↓, 1,   Glycolysis↓, 11,   Glycolysis↑, 1,   p‑GSK‐3β↓, 1,   HK2↓, 4,   HK2∅, 1,   HMG-CoA↓, 1,   lactateProd↓, 5,   LDHA∅, 1,   lipoGen↓, 1,   PDK1 / PDPK1↓, 1,   PFK↓, 1,   PFKP↓, 1,   PKM2↓, 7,   p‑PKM2↓, 1,   PLA2↓, 1,   Pyrim↓, 1,   SIRT1↑, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis↑, 35,   mt-Apoptosis↑, 1,   Bak↑, 1,   BAX↑, 18,   Bax:Bcl2↑, 4,   Bcl-2↓, 22,   Bcl-xL↓, 6,   BIM↑, 2,   Casp↑, 6,   Casp3↑, 21,   cl‑Casp3↑, 6,   Casp7↑, 2,   cl‑Casp7↑, 2,   Casp8↑, 4,   Casp8∅, 1,   cl‑Casp8↑, 1,   Casp9↑, 10,   cl‑Casp9↑, 3,   cFLIP↓, 1,   Cyt‑c↑, 7,   DR5↑, 3,   FasL↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 3,   GSDMD↑, 1,   GSDME↑, 1,   IAP1↓, 1,   iNOS↓, 1,   Mcl-1↓, 4,   MDM2↓, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   Necroptosis↑, 1,   p38↓, 1,   p38↑, 1,   Pyro↑, 2,   RIP3↑, 1,   p‑RIP3↑, 1,   survivin↓, 10,   TRAIL↑, 2,   TumCD↑, 2,   XIAP↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 16,   p‑Akt↓, 5,   AMPKα↑, 1,   cMET↓, 1,   EGFR↓, 3,   ERK↓, 3,   ERK↑, 2,   p‑ERK↓, 1,   p‑ERK↑, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   ILK↓, 1,   JAK1↓, 2,   JAK2↓, 3,   JNK↑, 4,   p‑JNK↑, 1,   LIFR/CD118↓, 1,   MAPK↓, 2,   mTOR↓, 11,   p‑mTOR↓, 3,   p70S6↓, 1,   p‑p70S6↓, 1,   P70S6K↓, 1,   PI3K↓, 13,   p‑PI3K↓, 1,   p‑PI3k/Akt/mTOR↓, 1,   PKA↓, 1,   PTEN↑, 3,   p‑RSK↑, 1,   SHP1↑, 1,   Sp1/3/4↓, 2,   STAT↓, 1,   STAT3↓, 11,   p‑STAT3↓, 3,   p‑STAT3↑, 1,   STAT4↑, 1,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cMyc↓, 4,   DNMTs↓, 2,   EZH2↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   p‑FOXO3↓, 1,   ac‑H3↑, 1,   H3K27ac∅, 1,   HDAC↓, 5,   IRF1↑, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-21↓, 1,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↑, 2,   miR-375↑, 1,   miR-422a↑, 1,   OCT4↓, 1,   other↓, 1,   other↝, 4,   SOX2↓, 1,   SUZ12↓, 1,   tumCV↓, 17,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 2,   p‑eIF2α↓, 1,   p‑eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   IRE1↑, 1,   PERK↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   Beclin-1/ATG6⇅, 1,   p‑Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 2,   LC3B-II↓, 1,   LC3B-II↑, 1,   LC3II↓, 1,   LC3II↑, 1,   LC3s↑, 1,   p62↓, 2,   p62↑, 5,   TumAuto↓, 1,   TumAuto↑, 12,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   DNArepair↓, 1,   hTERT/TERT↓, 1,   P53↑, 7,   p‑P53↑, 1,   PARP↑, 1,   p‑PARP↑, 1,   cl‑PARP↑, 7,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 4,   PCNA↝, 1,   Telomerase↓, 1,   TOP2↓, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK2↓, 4,   CDK4↓, 5,   CDK6↓, 2,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 9,   cycE/CCNE↓, 1,   FBXO5/EMI1↓, 1,   Ki-67↓, 12,   p19↑, 1,   P21↓, 1,   P21↑, 6,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 1,   p‑pRB↓, 1,   RB1↓, 1,   TumCCA?, 1,   TumCCA↑, 20,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   AXIN1↑, 1,   BMI1↓, 1,   BMP2↑, 1,   cFos↓, 1,   CSCs↓, 3,   Diff↑, 1,   FGF↓, 1,   Ki-67↓, 12,   LRP6↓, 1,   p‑LRP6↓, 1,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   OGF↑, 1,   OGFr↑, 1,   TumCG?, 1,   TumCG↓, 20,   TumCG↑, 1,   TumCP↓, 30,   Wnt↓, 4,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

ANGPT2↓, 1,   AP-1↓, 2,   ARG1/2↑, 1,   Ca+2↑, 3,   E-cadherin↑, 5,   EMT↓, 7,   MMP16↓, 1,   MMP2↓, 6,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 9,   N-cadherin↓, 4,   Na+↝, 1,   PAI-1/SERPINE1↑, 1,   Slug↓, 2,   Snail↓, 3,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 2,   TumCI↓, 15,   TumCMig↓, 14,   TumCMig↑, 1,   TumMeta↓, 10,   Twist↓, 1,   uPA↓, 1,   Vim↓, 5,   Zeb1↓, 1,   β-catenin/ZEB1↓, 7,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 16,   CD31/PECAM-1↓, 2,   eNOS↓, 1,   Hif1a↓, 12,   NO↓, 1,   VEGF↓, 13,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   EPR↑, 3,   GLUT1↓, 5,   GLUT3↓, 1,   MMP↓, 8,   MPT↑, 1,   Na+↝, 1,   SLC12A5↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 5,   COX2/PTGS2↑, 1,   Gal-3↓, 1,   IFN-γ↑, 2,   IL1↑, 1,   IL10↓, 2,   IL18↓, 1,   IL1β↓, 2,   IL1β↑, 1,   IL4↓, 2,   IL6↓, 6,   IL7↓, 1,   IL8↓, 2,   Imm↑, 5,   Inflam↓, 4,   M2 MC↓, 1,   pol-M2 MC↓, 1,   NF-kB↓, 16,   NLRP3↑, 1,   p65↓, 2,   PD-L1↓, 1,   PGE2↓, 1,   RANTES↓, 2,   SOCS1↑, 1,   TCF7/TCF1↓, 1,   TNF-α↓, 4,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   Estro↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen?, 1,   ChemoSen↑, 21,   ChemoSen⇅, 1,   CompStab↓, 1,   Dose?, 1,   Dose↝, 25,   Dose∅, 2,   eff↓, 19,   eff↑, 19,   eff↝, 1,   eff∅, 1,   GSTZ1↓, 1,   Half-Life↓, 2,   RadioS↑, 6,   selectivity↓, 1,   selectivity↑, 19,   Synergy↑, 17,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   ascitic↓, 1,   BG↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 3,   EZH2↓, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 6,   LDH↓, 1,   LDH↑, 1,   PD-L1↓, 1,   SUZ12↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   antiNeop↑, 1,   AntiTum↑, 5,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   fatigue↓, 2,   Mucositis↓, 1,   neuroP↑, 3,   OS↑, 4,   QoL↑, 2,   radioP↑, 2,   RenoP↑, 1,   Risk↓, 6,   Sleep↑, 1,   toxicity↓, 14,   toxicity↝, 1,   toxicity∅, 1,   TumNum?, 1,   TumNum↓, 1,   TumVol↓, 61,   TumVol⇅, 1,   TumVol∅, 1,   TumW↓, 96,   TumW⇅, 1,   TumW∅, 1,   Weight↑, 1,   Weight∅, 4,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 404

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↑, 2,   Fenton↓, 1,   GPx↑, 1,   GSH↑, 1,   HO-1↑, 1,   Iron∅, 1,   lipid-P↓, 2,   MDA↓, 1,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NRF2↑, 2,   RNS↓, 1,   ROS↓, 3,   SOD↑, 2,   TAC↑, 1,   TBARS↓, 1,   VitE↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp3↓, 1,   Casp9↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   ERK↓, 1,   JAK2↑, 1,   PI3K↑, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD25+↑, 1,   CD4+↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   IFN-γ↑, 1,   IL10↑, 2,   IL1β↓, 1,   IL4↑, 2,   IL6↓, 1,   Inflam↓, 3,   M2 MC↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 2,   NLRP3↓, 1,   PGE2↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,   Treg lymp↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 2,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   NLR↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 2,   hepatoP↑, 1,   neuroP↑, 2,   OS↑, 1,   Stroke↓, 1,   toxicity↓, 6,   toxicity↝, 1,   toxicity∅, 1,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↓, 1,   Bacteria↓, 1,  
Total Targets: 84

Scientific Paper Hit Count for: TumW, Tumor Weight
5 Apigenin (mainly Parsley)
4 phytic acid, Inositol hexakisphosphate
3 EGCG (Epigallocatechin Gallate)
3 Sulforaphane (mainly Broccoli)
3 Shikonin
2 cetuximab
2 Metformin
2 Ashwagandha(Withaferin A)
2 Chlorogenic acid
2 immunotherapy
2 Dichloroacetate
2 Chemotherapy
2 Diindolylmethane
2 Ferulic acid
2 Cisplatin
2 Ginkgetin
2 Hydrogen Gas
2 Honokiol
2 Inositol
2 Linalool
2 Melatonin
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Piperlongumine
1 3-bromopyruvate
1 Allyl isothiocyanate
1 Allicin (mainly Garlic)
1 Andrographis
1 Aspirin
1 Baicalein
1 Benzyl isothiocyanate
1 borneol
1 Carvacrol
1 Cannabidiol
1 Celastrol
1 chaetocin
1 chitosan
1 Chrysin
1 Cinnamon
1 Curcumin
1 Cynaropicrin
1 Bortezomib
1 Diclofenac
1 Docosahexaenoic Acid
1 5-fluorouracil
1 Ormeloxifene (Centchroman)
1 Evodiamine
1 Fenbendazole
1 Formononetin
1 Flaxseed Oil
1 Fucoidan
1 Gallic acid
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 Hibiscus sabdariffa
1 Hyperoside
1 Indole-3-carbinol
1 Isobavachalcone
1 Inulin Prebiotic
1 capecitabine
1 Ivermectin
1 Isovitexin
1 Kaempferol
1 Licochalcone A
1 low dose naltrexone
1 doxorubicin
1 Luteolin
1 Lycopene
1 Magnolol
1 Radiotherapy/Radiation
1 Matrine
1 mebendazole
1 Modified Citrus Pectin
1 methylseleninic acid
1 Mangiferin
1 Naringin
1 Propolis -bee glue
1 Phenethyl isothiocyanate
1 Phycocyanin
1 Pterostilbene
1 Resveratrol
1 Sesamin
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Walnut
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:915  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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