| Source: |
| Type: |
| The term "IL-1" is often used as an umbrella term for the interleukin-1 family, which includes multiple cytokines. The two best-known members are IL-1α and IL-1β. IL-1β is secreted from cells and plays a major systemic role in inflammation. It is a crucial mediator in the inflammatory response and is involved in the fever response, activation of endothelial cells, and leukocyte recruitment. Its increased expression is commonly linked to: – Promotion of a pro-inflammatory microenvironment that supports tumor growth. – Enhanced angiogenesis, invasion, and metastasis. – Recruitment of myeloid cells that may further suppress antitumor immunity. High expression of either tends to be associated with a more aggressive phenotype and worse prognosis in many cancer types. |
| 5932- | CAR, | Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome |
| - | in-vivo, | IBD, | NA | - | in-vivo, | Park, | NA |
| 5925- | CAR, | Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review |
| - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | Stroke, | NA |
| 3869- | Carno, | Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation |
| - | Review, | AD, | NA | - | Review, | Stroke, | NA |
| 5943- | Cela, | Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases |
| - | Review, | Arthritis, | NA | - | Review, | IBD, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 2393- | Cela, | Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect |
| - | in-vivo, | Sepsis, | NA | - | in-vitro, | Nor, | RAW264.7 |
| 2392- | Cela, | The role of natural products targeting macrophage polarization in sepsis-induced lung injury |
| - | Review, | Sepsis, | NA |
| 6018- | CGA, | Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems |
| - | Review, | Var, | NA | - | Review, | RCC, | NA |
| 6007- | CGA, | A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer |
| - | Review, | CRC, | NA |
| 6010- | CGA, | The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review |
| - | Review, | Nor, | NA |
| 5988- | Chit, | Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways |
| - | Review, | Var, | NA |
| 2781- | CHr, | PBG, | Chrysin a promising anticancer agent: recent perspectives |
| - | Review, | Var, | NA |
| 2782- | CHr, | Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives |
| - | Review, | Var, | NA | - | Review, | Stroke, | NA | - | Review, | Park, | NA |
| 2785- | CHr, | Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin |
| - | Review, | Var, | NA |
| 2794- | CHr, | An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches |
| - | Review, | Park, | NA | - | Review, | Stroke, | NA |
| 3795- | CUR, | Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence |
| - | Review, | AD, | NA |
| 3583- | CUR, | Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers |
| - | Review, | Arthritis, | NA |
| 3581- | CUR, | Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer's Disease |
| - | NA, | AD, | NA |
| 3576- | CUR, | Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease |
| - | Review, | AD, | NA |
| 3575- | CUR, | The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse |
| - | in-vivo, | AD, | NA |
| 3574- | CUR, | The effect of curcumin (turmeric) on Alzheimer's disease: An overview |
| - | Review, | AD, | NA |
| 2818- | CUR, | Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways |
| - | Review, | AD, | NA |
| 3225- | EGCG, | Epigallocatechin‐3‐Gallate Ameliorates Diabetic Kidney Disease by Inhibiting the TXNIP/NLRP3/IL‐1β Signaling Pathway |
| - | in-vitro, | Nor, | NA | - | in-vivo, | Nor, | NA |
| 2992- | EGCG, | Effects of Epigallocatechin-3-Gallate on Matrix Metalloproteinases in Terms of Its Anticancer Activity |
| - | Review, | Var, | NA |
| 3778- | FA, | Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review |
| - | Review, | AD, | NA |
| 3714- | FA, | Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review |
| - | Review, | AD, | NA |
| 3715- | FA, | CUR, | PS, | The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice |
| - | in-vivo, | AD, | NA |
| 2861- | FIS, | The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress |
| - | Review, | Nor, | NA | - | Review, | Stroke, | NA | - | Review, | Park, | NA |
| 2862- | FIS, | Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rat |
| - | in-vivo, | Diabetic, | NA |
| 2841- | FIS, | Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer |
| - | in-vitro, | Nor, | RAW264.7 | - | in-vitro, | Liver, | HepG2 | - | in-vitro, | Liver, | Hep3B | - | in-vitro, | Liver, | HUH7 |
| 3723- | Gb, | Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies |
| - | Review, | AD, | NA |
| 4003- | Gins, | Neuroprotective Potentials of Panax Ginseng Against Alzheimer's Disease: A Review of Preclinical and Clinical Evidences |
| - | Review, | adrenal, | NA |
| 2523- | H2, | Prospects of molecular hydrogen in cancer prevention and treatment |
| - | Review, | Var, | NA |
| 2514- | H2, | Hydrogen: A Novel Option in Human Disease Treatment |
| - | Review, | NA, | NA |
| 2503- | H2, | Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report |
| - | Case Report, | Lung, | NA |
| 3770- | H2, | Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3772- | H2, | Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis |
| - | in-vivo, | AD, | NA |
| 3773- | H2, | Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases |
| - | Review, | Park, | NA |
| 3767- | H2, | The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges |
| - | Review, | AD, | NA |
| 4238- | HNK, | Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint |
| - | Review, | AD, | NA | - | NA, | Park, | NA |
| 2871- | HNK, | Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling |
| - | in-vivo, | Nor, | NA |
| 2869- | HNK, | Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 2885- | HNK, | Honokiol: a novel natural agent for cancer prevention and therapy |
| 4292- | LT, | Luteolin for neurodegenerative diseases: a review |
| - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | MS, | NA | - | Review, | Stroke, | NA |
| 2921- | LT, | Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies |
| - | Review, | Nor, | NA |
| 2919- | LT, | Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence |
| - | Review, | Var, | NA |
| 3528- | Lyco, | The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene |
| - | Review, | Nor, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3264- | Lyco, | Pharmacological potentials of lycopene against aging and aging‐related disorders: A review |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | Stroke, | NA |
| 3278- | Lyco, | Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells |
| - | in-vitro, | Colon, | SW480 |
| 1711- | Lyco, | Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review |
| - | Review, | Var, | NA |
| 4230- | Lyco, | Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway |
| - | in-vivo, | AD, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:978 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid