IL1β Cancer Research Results

IL1β, interleukin-1 beta: Click to Expand ⟱
Source:
Type:
The term "IL-1" is often used as an umbrella term for the interleukin-1 family, which includes multiple cytokines. The two best-known members are IL-1α and IL-1β.
IL-1β is secreted from cells and plays a major systemic role in inflammation. It is a crucial mediator in the inflammatory response and is involved in the fever response, activation of endothelial cells, and leukocyte recruitment.
Its increased expression is commonly linked to:
  – Promotion of a pro-inflammatory microenvironment that supports tumor growth.
  – Enhanced angiogenesis, invasion, and metastasis.
  – Recruitment of myeloid cells that may further suppress antitumor immunity.

High expression of either tends to be associated with a more aggressive phenotype and worse prognosis in many cancer types.
Scientific Papers found: Click to Expand⟱
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
3515- Bor,    EVIDENCE THAT BORON DOWN-REGULATES INFLAMMATION THROUGH THE NF-(KAPPA)B PATHWAY
- in-vitro, Nor, NA
*TNF-α↓, *IL1β↓, *MIP‑1α/CCL3↓, *iNOS↓, *NF-kB↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,
4270- Bos,    Boswellic acids ameliorate neurodegeneration induced by AlCl3: the implication of Wnt/β-catenin pathway
- in-vivo, AD, NA
*memory↑, *AChE↓, *Aβ↓, *TNF-α↓, *IL1β↓, *lipid-P↓, *TAC↑, *BDNF↑, *β-catenin/ZEB1↑, *Dose↑,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2/PTGS2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6553- BSB,    Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms
- Review, Nor, NA
*ROS↓, *Inflam↓, *Inf↓, *neuroP↑, *RNS↓, *MDA↓, *GSH↑, *MPO↓, *SOD↑, *Catalase↑, *Bcl-2↑, *BAX↓, *P53↓, *APAF1↓, *Casp3↓, *Casp9↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *ERK↓, *JNK↓, *NF-kB↓, *p38↓, *cognitive↑, *BChE↓,
6557- BSB,    Alpha-bisabolol protects against neonatal asthma by suppressing airway inflammatory signaling
- in-vivo, Nor, NA
*ROS↓, *Inflam↓, *IL1β↓, *IL6↓, *IL8↓, *IL17↓, *CXCR4↓, *COX2/PTGS2↓, *TLR4↓, *NO↓, *MDA↓, *XO↓, *antiAll↑,
5742- Buty,    Butyrate: A Double-Edged Sword for Health?
- Review, Var, NA
HCAR2↑, Inflam↓, HDAC↓, *IFN-γ↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↑, *LTA/TNF-β↑, *NF-kB↓, *ROS↓, PPARγ↓, Weight↓,
5740- Buty,    A Review of Nutritional Regulation of Intestinal Butyrate Synthesis: Interactions Between Dietary Polysaccharides and Proteins
- Review, RCC, NA
*eff↓, Dose↝, eff↑, HDAC↓, ac‑H3↓, ac‑H4↓, *HCAR2↑, *Inflam↓, *ROS↓, *NRF2↑, *GSH↑, *CLDN1↑, *ZO-1↑, IL1β↓, IL6↓, COX2/PTGS2↓, eff↝, eff↑, other↝,
4264- CA,    Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2HO-1 Pathway
- in-vivo, AD, NA
*NRF2↑, *HO-1↑, *Trx1↑, *BDNF↑, *5HT↑, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓,
5830- CAP,    Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro
- in-vitro, Nor, HK-2
*IL1β↓, *IL18↓, *TRPV1↑, *ROS↓, *MMP↑, *Apoptosis↓, *RenoP↑, *Inflam↓, *UCPs↑,
5860- CAP,    Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *memory↑, *Pain↓, *TRPV1↑, *Aβ↓, *tau↓, *cognitive↑, *Risk↓, *motorD↓, *ROS↓, *TNF-α↓, *IL1β↓, *Stroke↓, *Risk↓,
5900- CAR,  TV,    Lights and Shadows of Essential Oil-Derived Compounds: Antimicrobial and Anti-Inflammatory Properties of Eugenol, Thymol, Cinnamaldehyde, and Carvacrol
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *cardioP↑, *neuroP↑, *NADPH↓, *NRF2↑, *HO-1↑, *IL1β↓, *TNF-α↓,
5932- CAR,    Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
- in-vivo, IBD, NA - in-vivo, Park, NA
*GutMicro↑, Risk↓, *Inflam↓, *antiOx↓, *ZO-1↑, *iNOS↓, *IL6↓, *NO↓, *PGE2↓, *memory↑, *TLR4↓, *NF-kB↓, *IBI↑, *CLDN3↑, *CLDN1↑, *MUC1↑, *OCLN↑, *iNOS↑, *COX2/PTGS2↓, *IFN-γ↓, IL1β↓, ADAM10?,
5925- CAR,    Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2/PTGS2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *Stroke↓, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2/KDR/Flk1↓, NF-kB↓,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
2392- Cela,    The role of natural products targeting macrophage polarization in sepsis-induced lung injury
- Review, Sepsis, NA
TNF-α↓, IL1β↓, IL6↓, Warburg↓, PKM2↓, NRF2↑, HO-1↑, NF-kB↓, iNOS↓, M1↓,
2393- Cela,    Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- in-vivo, Sepsis, NA - in-vitro, Nor, RAW264.7
OS↑, PKM2↓, Glycolysis↓, Warburg↓, Inflam↓, HMGB1↓, ALAT↓, AST↓, TNF-α↓, IL1β↓, IL6↓,
6615- Cen,    Asiaticoside suppresses cell proliferation by inhibiting the NF-κB signaling pathway in colorectal cancer
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
Dose↝, TumCP↓, selectivity↑, MMP↓, Apoptosis↑, TumCCA↑, NF-kB↓, CDK4↓, cycD1/CCND1↓, Casp9↑, Casp3↑, Bax:Bcl2↑, TumCG↓, ChemoSen↑, TNF-α↓, IL1β↓, P53↑, P21↑,
6660- Cen,    Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury in BALB/c mice
- in-vivo, LiverDam, NA
*hepatoP↑, *NO↓, *lipid-P↓, *IL1β↓, *ALAT↓, *AST↓, *LDH↓, GSH↑, MDA↓,
6651- Cen,    Study of the cytotoxicity of asiaticoside on rats and tumour cells
- vitro+vivo, BC, MCF7
Casp3↑, TNF-α↓, IL1β↓, Apoptosis↑, TumCCA↑, TumVol↓, radioP↑, Inflam↓,
6018- CGA,    Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems
- Review, Var, NA - Review, RCC, NA
*BioAv↓, *Inflam↓, *TNF-α↓, *NO↓, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *IL6↓, *IL1β↓, *TLR2↓, *MAPK↓, *NRF2↓, *HO-1↑, *NQO1↑, *cardioP↑, *neuroP↑, *SOD↑, *GSH↑, *ROS↓, *LDH↓, *MDA↓, *cognitive↑, *eff↑,
6007- CGA,    A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer
- Review, CRC, NA
antiOx↑, TumCCA↑, Apoptosis↑, Wnt↝, PI3K↝, MAPK↝, ROS↓, BioAv↝, P53↑, P21↑, CDK1↑, Ki-67↓, Ca+2↑, p‑Akt↓, mTOR↓, GSH↑, NRF2↑, HO-1↑, COX2/PTGS2↓, TNF-α↓, IL1β↓, IL6↓,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2/PTGS2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
5988- Chit,    Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways
- Review, Var, NA
DDS↑, *Cartilage↑, *Wound Healing↑, Imm↑, cGAS–STING↑, STAT1↑, NLRP3↑, *DCells↑, *IL10↓, *TGF-β1↓, *TNF-α↓, IL1β↓, ROS↑,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, Synergy↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2/PTGS2↓, NF-kB↓, PDK1 / PDPK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, Synergy↑, Synergy↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, Synergy↑,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, Synergy↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
7434- Chy,    Chyawanprash, An Ancient Indian Ayurvedic Medicinal Food, Regulates Immune Response in Zebrafish Model of Inflammation by Moderating Inflammatory Biomarkers
- in-vivo, Nor, NA
*Inflam↓, *IL6↓, *TNF-α↓, *IL1β↓,
6624- Cic,    Chicoric acid supplementation ameliorates cognitive impairment induced by oxidative stress via promotion of antioxidant defense system
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, *TNF-α↓, *IL1β↓, *MDA↓, *Catalase↑, *GSH↑, *NRF2↑, *mtDam↓, *Inflam↓, *Apoptosis↓, *ROS↓, *cognitive↑, *Aβ↓, *BDNF∅, *APP↓, *BACE/β-secretase↓,
6625- Cic,  Ech,    Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB
- in-vivo, AD, NA
*memory↑, *Aβ↓, *BACE/β-secretase↓, *MAPK↓, *NF-kB↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *BDNF∅, *MMPs↓,
6626- Cic,  Ech,    Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer’s Disease Models
- in-vivo, Nor, NA
*antiOx↑, *Obesity↓, *memory↑, *Aβ↓, *MAPK↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *NF-kB↓,
6309- Cro,    Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway
- in-vitro, CRC, HCT116
tumCV↓, TumCP↓, Ki-67↓, Apoptosis↓, Inflam↓, ROS↑, MMP↓, JAK2↓, STAT3↓, ERK↓, MIP2↓, IL6↓, MCP1/CCL2↓, IL8↓, IL1β↓, TNF-α↓, SOD↓, Catalase↓, GSH↓, ROS↑, mtDam↑,
6304- Cro,    Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ
- in-vitro, BC, NA
NF-kB↓, tumCV↓, TumCP↓, TNF-α↓, IL1β↓, Inflam↓, PRKCQ/PKCθ↓,
6300- Cro,    Interaction of saffron and its constituents with Nrf2 signaling pathway: A review
- Review, Nor, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑, *NRF2↑, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL10↓, *IL1β↓, *TNF-α↓, *HO-1↑, ROS↑, NQO1↑, NRF2↑, HO-1↑, NQO2↑, LDHA↓, ATP↓, *hepatoP↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *ROS↓, *cardioP↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *Apoptosis↓, *miR-34a↓, *SIRT1↑, chemoP↑,
6299- Cro,    Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *ALP↓, *MDA↓, *ROS↓, *Catalase↑, *SOD↑, *IL6↓, *IL1β↓, *TNF-α↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *hepatoP↑, *GSH↑,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27/CDKN1B↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
6531- CRV,    D-carvone attenuates LPS-induced acute lung injury via TLR4/NF-κB and Nrf2/HO-1 signaling pathways in rats
- in-vivo, Nor, NA
*TRAF1↓, *IL1β↓, *TNF-α↓, *ROS↓, *MDA↓, *GSH↑, *SOD↑, *Inflam↓, *NRF2↑, *Bcl-2↑, *IL8↓, *antiOx↑,
7429- CS,    Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
- Review, Nor, NA - Review, IBD, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *ICAM-1↓, *IL1β↓, *IL6↓, *MUC1↑, *OCLN↑, *IBI↑, *ROS↓, *cardioP↑, *SOD↑, *GPx↑, *GSH↑, *TG/TAG↓, *LDL↓, *neuroP↑, *5HT↑, *BDNF↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2/PTGS2↓, *MCP1/CCL2↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE/β-secretase↓, *AChE↓, *LDL↓,
3583- CUR,    Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers
- Review, Arthritis, NA
*TNF-α↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMPs↓, *Synergy↑,
3581- CUR,    Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer's Disease
- NA, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *NRF2↑, *NF-kB↓, *cognitive↑, *ROS↓, *MDA↓, *SOD↑, *Catalase↑, *INF-γ↓, *IL4↓, *memory↑, *TNF-α↓, *IL1β↓,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
3575- CUR,    The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
- in-vivo, AD, NA
*antiOx↑, *ROS↓, *IL1β↓, *Aβ↓, *Inflam↓, *toxicity↓,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2/PTGS2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *Synergy↑,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,

Showing Research Papers: 51 to 100 of 330
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 330

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 5,   Catalase↓, 5,   Catalase↑, 2,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 12,   GSH↑, 5,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 2,   H2O2↑, 2,   HO-1↓, 3,   HO-1↑, 8,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 7,   MDA↓, 3,   MDA↑, 3,   MPO↓, 2,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 6,   NRF2↑, 9,   ROS?, 1,   ROS↓, 19,   ROS↑, 54,   ROS⇅, 3,   ROS↝, 1,   mt-ROS↑, 1,   SOD?, 1,   SOD↓, 6,   SOD↑, 5,   SOD2↓, 2,   TAC↓, 1,   Thiols↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   EGF↓, 2,   ETC↓, 1,   MFN2↑, 1,   mtDam↑, 3,   OXPHOS↓, 1,   PDH↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ACLY↓, 1,   ALAT↓, 2,   AMPK↓, 2,   AMPK↑, 6,   ATP↓, 3,   ATP↑, 1,   mt-ATP↓, 1,   FASN↓, 3,   FDG↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   GlutMet↓, 1,   Glycolysis↓, 9,   GSK‐3β↓, 4,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 2,   Histones↝, 1,   HK2↓, 7,   HMG-CoA↓, 1,   lactateProd↓, 4,   LDHA↓, 4,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFK↓, 3,   PKM2↓, 7,   p‑PKM2↓, 1,   Pyruv↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 2,   TCA↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   Apoptosis↓, 3,   Apoptosis↑, 41,   mt-Apoptosis↑, 1,   ASC↓, 1,   ASC↑, 1,   BAD↑, 1,   Bak↓, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 25,   Bax:Bcl2↑, 5,   Bcl-2↓, 30,   Bcl-2↑, 1,   Bcl-xL↓, 6,   BID↑, 1,   BNIP3↑, 1,   BNIP3↝, 1,   Casp↓, 1,   Casp↑, 6,   Casp↝, 1,   Casp1↓, 5,   cl‑Casp1↓, 1,   Casp12?, 1,   Casp3↓, 1,   Casp3↑, 38,   cl‑Casp3↑, 4,   cl‑Casp3⇅, 1,   Casp7↑, 3,   cl‑Casp7↑, 1,   Casp8↑, 11,   cl‑Casp8↑, 1,   Casp9↑, 20,   cl‑Casp9↑, 2,   Cyt‑c↑, 21,   mt-Cyt‑c↓, 1,   Diablo↑, 2,   DR5↑, 5,   Fas↓, 1,   Fas↑, 6,   FasL↑, 3,   Ferroptosis↓, 1,   Ferroptosis↑, 2,   GranB/GZMB↝, 1,   GSDMD↑, 1,   GSDME↑, 1,   cl‑GSDME↑, 1,   IAP1↓, 3,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 13,   Mcl-1↓, 5,   MDM2↓, 2,   MDM2↑, 2,   p‑MDM2↓, 1,   p38↓, 2,   p38↑, 5,   p‑p38↓, 2,   p‑p38↑, 1,   Perforin↝, 1,   PUMA↑, 1,   Pyro↑, 3,   survivin↓, 13,   TRAIL↑, 1,   TumCD↑, 1,   TumCD∅, 1,   XIAP↓, 7,   XIAP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 32,   Akt↑, 1,   p‑Akt↓, 9,   CK2↓, 1,   cMET↓, 1,   CREB↓, 1,   cSrc↓, 2,   EGFR↓, 8,   EGFR↑, 2,   ERK↓, 14,   ERK↑, 3,   p‑ERK↓, 4,   FGFR1↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 5,   HGF/c-Met↓, 1,   HRAS↓, 1,   IKKα↓, 2,   p‑IKKα↓, 1,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 7,   JNK↓, 3,   JNK↑, 4,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 9,   MAPK↑, 3,   MAPK↝, 2,   MARK4↓, 1,   mTOR↓, 22,   mTOR↑, 1,   mTOR↝, 1,   p‑mTOR↓, 1,   P70S6K↓, 2,   PDGFRB↓, 1,   PI3K↓, 23,   PI3K↝, 1,   p‑PI3K↓, 2,   PKCδ↓, 1,   PRKCQ/PKCθ↓, 1,   PTEN↓, 1,   PTEN↑, 3,   Raf↓, 1,   RAS↓, 4,   RCC1↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 2,   p‑Src↓, 1,   STAT↓, 2,   STAT3↓, 25,   p‑STAT3↓, 2,   STAT4↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 4,   cMyc↓, 12,   DNMT1↓, 4,   DNMT3A↓, 1,   DNMTs↓, 1,   EZH2↓, 2,   FOXM1↓, 2,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO4↓, 2,   H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 1,   H4↓, 1,   ac‑H4↓, 1,   ac‑H4↑, 1,   HDAC↓, 11,   HDAC1↓, 2,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 1,   miR-124-3p↓, 1,   miR-21↑, 1,   MYCN↓, 1,   OCT4↓, 4,   other↓, 1,   other↑, 3,   other↝, 2,   PAX2↓, 1,   SOX2↓, 2,   SOX9↓, 1,   tumCV↓, 13,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 6,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↑, 7,   GRP78/BiP↑, 4,   HSP27↓, 2,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 1,   HSP90↓, 4,   NQO2↑, 1,   PERK↑, 3,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 5,   CTSK↓, 1,   LC3B-II↑, 2,   LC3II↑, 3,   p62↓, 3,   TumAuto↑, 9,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 13,   DNArepair↓, 1,   ERCC1↓, 1,   hTERT/TERT↓, 5,   P53↓, 1,   P53↑, 25,   P53↝, 2,   p53 Wildtype↑, 1,   PARP↓, 2,   PARP↑, 6,   cl‑PARP↓, 1,   cl‑PARP↑, 10,   PCNA↓, 11,   POLD1↓, 1,   Telomerase↓, 2,   TOP1↓, 2,   TOP2↓, 3,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 3,   CDK1↑, 4,   p‑CDK1↓, 1,   CDK2↓, 3,   CDK2↑, 2,   CDK4↓, 11,   CDK4↑, 1,   CDK6↓, 3,   CDK6↑, 2,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 7,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 17,   cycD1/CCND1↑, 2,   cycE/CCNE↓, 2,   Ki-67↓, 12,   mitA↑, 1,   P21↓, 1,   P21↑, 15,   p27/CDKN1B↑, 5,   pRB↓, 1,   p‑pRB↓, 2,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↓, 2,   TumCCA↑, 40,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   ALDH1A1↓, 1,   BMP7/OP1↓, 2,   CD133↓, 1,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 11,   Diff↓, 1,   Diff↑, 3,   EIF4E↓, 1,   EP2↓, 1,   FGF↓, 2,   HH∅, 1,   IGF-1↓, 3,   IGFBP3↑, 1,   Ki-67↓, 12,   Let-7↑, 1,   Nanog↓, 3,   NOTCH↓, 3,   NOTCH1↓, 2,   NOTCH1↑, 3,   NOTCH3↓, 1,   Shh↓, 2,   STAT1↑, 1,   TumCG↓, 15,   TumCG↑, 1,   TumCP↓, 40,   TumCP↑, 1,   Wnt↓, 9,   Wnt↝, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   AXL↓, 1,   BACH1↓, 1,   Ca+2↑, 4,   Ca+2↝, 1,   cal2↓, 1,   Cdc42↓, 1,   COL4A3↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 12,   EMT↓, 21,   EMT↑, 1,   FAK↓, 2,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 3,   GIT1↓, 1,   ITGB1↓, 1,   KAI1/CD82↑, 1,   KRAS↓, 2,   LAMs↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 27,   MMP7↓, 1,   MMP9↓, 21,   MMP9↑, 2,   MMPs↓, 10,   MTA1↓, 1,   N-cadherin↓, 10,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 2,   Slug↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 5,   TET1↑, 3,   TGF-β↓, 5,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 3,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 15,   TumCMig↓, 22,   TumMeta↓, 18,   Twist↓, 7,   Tyro3↓, 1,   uPA↓, 2,   uPAR↓, 1,   Vim?, 1,   Vim↓, 8,   Vim↑, 1,   Zeb1↓, 4,   β-catenin/ZEB1↓, 13,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 23,   angioG↑, 1,   EGR4↓, 1,   Hif1a↓, 15,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 5,   NO↑, 1,   TYMP/ECGF1↓, 1,   VCAM-1↓, 2,   VEGF↓, 28,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   CLDN1↓, 2,   EPR↑, 1,   GLUT1↓, 2,   GLUT3↓, 1,   MMP↓, 16,   MMP↑, 1,   MMP↝, 1,   MPT↑, 1,   TRPV1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD44↓, 4,   CD47↓, 1,   CD8+↑, 3,   cGAS–STING↑, 1,   COX2/PTGS2↓, 39,   COX2/PTGS2↑, 2,   COX2/PTGS2∅, 1,   CXCL6/GCP-2↓, 1,   CXCR3↓, 1,   CXCR4↓, 4,   DR4↑, 1,   GM-CSF↓, 1,   HCAR2↑, 1,   HMGB1↓, 3,   ICAM-1↓, 4,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 5,   IL12↓, 2,   IL18↓, 4,   IL18↑, 1,   IL1β↓, 84,   IL1β↑, 7,   IL1β∅, 1,   IL2↓, 2,   IL2↑, 3,   IL6↓, 50,   IL6↑, 1,   IL8↓, 8,   IL8↑, 1,   Imm↑, 1,   Inflam↓, 28,   IRAK4↓, 1,   LPS↓, 1,   M1↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   MyD88↓, 1,   NF-kB↓, 52,   NF-kB↑, 2,   p‑NF-kB↑, 1,   NK cell↑, 4,   NLRP3↓, 8,   NLRP3↑, 3,   p50↓, 2,   p65↓, 2,   p‑p65↓, 2,   PD-1↓, 3,   PD-L1↓, 5,   PGE2↓, 7,   PGE2↑, 1,   PSA↓, 2,   Th1 response↑, 1,   TLR4↓, 8,   TNF-α↓, 53,   TNF-α↑, 6,   TNF-α∅, 1,   Treg lymp↓, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 6,   BioAv↑, 9,   BioAv↝, 7,   BioEnh↑, 1,   ChemoSen↑, 39,   ChemoSen↝, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   DDS↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 4,   Dose↝, 20,   Dose∅, 4,   eff↓, 5,   eff↑, 13,   eff⇅, 1,   eff↝, 4,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↝, 3,   MDR1↓, 2,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 9,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,   P450↓, 2,   RadioS↑, 16,   selectivity↑, 20,   Synergy↑, 38,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AR↓, 4,   AST↓, 1,   CA125↓, 1,   CEA↓, 3,   CRP↓, 4,   CYFRA21-1↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 8,   EGFR↑, 2,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 5,   hTERT/TERT↓, 5,   IL6↓, 50,   IL6↑, 1,   KRAS↓, 2,   LDH↓, 6,   LDH↑, 3,   LDH↝, 1,   i-LDH↓, 1,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 5,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 16,   AntiTum↑, 8,   cachexia↓, 2,   cardioP↑, 4,   chemoP?, 1,   chemoP↑, 15,   chemoPv↑, 3,   ChemoSideEff↓, 3,   cognitive?, 1,   cognitive↑, 3,   hepatoP↑, 6,   K17↓, 1,   neuroP↑, 6,   NP/CIPN↓, 2,   OS↑, 6,   Pain↓, 2,   PFS↑, 1,   QoL↑, 4,   radioP↑, 8,   RenoP↑, 4,   Risk↓, 5,   toxicity↓, 4,   TumVol↓, 11,   TumW↓, 4,   Weight↓, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   Bacteria↓, 1,   GutMicro↑, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 1,  
Total Targets: 589

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 6,   antiOx↑, 90,   ARE↑, 3,   Bil↓, 1,   Bil↑, 2,   Catalase↓, 1,   Catalase↑, 70,   Copper↓, 1,   DPPH↓, 1,   DUOX1↓, 1,   Fenton↓, 4,   GCLC↑, 2,   GCLC↝, 1,   GCLM↑, 2,   GCLM↝, 1,   GPx↓, 1,   GPx↑, 42,   GPx1↑, 2,   GPx4↑, 4,   GSH↑, 77,   GSR↓, 3,   GSR↑, 8,   GSSG↓, 1,   GSTs↓, 4,   GSTs↑, 9,   H2O2↓, 5,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 3,   HNE↓, 1,   HO-1↓, 3,   HO-1↑, 68,   HO-2↓, 1,   Iron↓, 2,   Keap1↓, 4,   Keap1↑, 1,   Keap1↝, 2,   lipid-P↓, 54,   mt-lipid-P↓, 1,   MDA↓, 72,   MPO↓, 11,   NOX↓, 2,   NOX1↓, 1,   NOX2↓, 3,   NOX4↓, 5,   NQO1↑, 17,   NQO1↝, 1,   NQO1∅, 1,   Nrf1↑, 1,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 97,   Prx↑, 1,   RNS↓, 3,   ROS?, 3,   ROS↓, 159,   ROS⇅, 1,   mt-ROS?, 1,   mt-ROS↓, 4,   SOD?, 1,   SOD↓, 2,   SOD↑, 97,   SOD1↑, 6,   SOD2↑, 3,   TAC↑, 10,   TBARS↓, 4,   Thiols↑, 1,   Trx1↑, 1,   TrxR↑, 2,   UCPs↑, 1,   uricA↓, 1,   VitC↑, 5,   VitE↓, 1,   VitE↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 8,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↑, 1,   EGF↓, 1,   FIS1↓, 1,   Insulin↑, 3,   MFN1↓, 1,   MFN2↓, 1,   mitResp↑, 1,   mtDam↓, 6,   OPA1↓, 1,   OXPHOS↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 5,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 1,   SIRT3↑, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   15-LOX/ALOX15↓, 1,   5LO↓, 7,   ACADS/SCAD↑, 1,   ACC↑, 1,   ACSL4↓, 1,   adiP↓, 1,   adiP↑, 1,   ALAT↓, 19,   AMPK↑, 13,   ATP↑, 12,   cAMP↑, 2,   CPT1A↑, 1,   CRM↑, 1,   FAM↑, 1,   G6PD↑, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↑, 2,   GSK‐3β↓, 15,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 2,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 11,   lipidLev↓, 3,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 7,   NADPH↑, 3,   PKM2↓, 2,   SIRT1↑, 15,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 24,   ASC?, 1,   ASC↓, 5,   BAD↓, 1,   BAX↓, 17,   BAX↑, 2,   Bax:Bcl2↓, 3,   Bcl-2↓, 4,   Bcl-2↑, 14,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp1?, 1,   Casp1↓, 8,   cl‑Casp1↓, 2,   proCasp1↓, 1,   Casp12↓, 2,   Casp3↓, 37,   Casp3↑, 2,   cl‑Casp3↓, 1,   Casp6↓, 1,   Casp8↓, 2,   Casp9↓, 17,   Casp9↑, 1,   Cyt‑c↓, 5,   Cyt‑c∅, 1,   Fas↓, 1,   Ferroptosis↓, 4,   GranB/GZMB↓, 1,   GSDMD↓, 3,   iNOS↓, 58,   iNOS↑, 3,   MLKL↓, 1,   necrosis↓, 2,   p38↓, 11,   p‑p38↓, 1,   Pyro?, 1,   Pyro↓, 1,   RIP1↓, 1,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↑, 9,   p‑Akt↑, 2,   AKT1↓, 1,   Akt2↓, 1,   CaMKII ↓, 1,   CREB↓, 1,   CREB↑, 3,   p‑CREB↑, 1,   EGFR↓, 2,   ERK↓, 9,   ERK↑, 3,   p‑ERK↓, 1,   p‑ERK↑, 1,   HCAR2↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 2,   p‑IKKα↓, 2,   JAK↓, 1,   p‑JAK1↓, 1,   JAK2↓, 1,   JAK2↑, 2,   p‑JAK2↓, 1,   JNK↓, 10,   JNK↑, 1,   p‑JNK↓, 5,   MAPK?, 1,   MAPK↓, 21,   MAPK↑, 3,   MAPK↝, 1,   p‑MAPK?, 1,   p‑MAPK↓, 1,   mTOR↓, 5,   mTOR↑, 2,   p‑mTOR↓, 2,   P70S6K↓, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 7,   PI3K↑, 7,   PKA↑, 1,   PKCδ?, 1,   PKCδ↓, 1,   PKCδ↑, 2,   PP2A↑, 1,   PTEN↓, 2,   STAT↓, 1,   STAT3↓, 6,   STAT3↑, 3,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cMyc↓, 1,   FOXO↑, 1,   FOXO3↑, 2,   HDAC↓, 3,   HDAC2↓, 1,   HDAC3↓, 1,   miR-23a-3p↓, 1,   miR-34a↓, 1,   other↓, 3,   other↑, 8,   other↝, 12,   SOX9↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 2,   ER Stress↓, 8,   GRP78/BiP↓, 6,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 6,   HSP70/HSPA5↝, 1,   HSPs↑, 1,   IRE1↓, 2,   PERK↓, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↓, 1,   autophagy↓, 1,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3II↑, 1,   MitoP↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 2,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   P53↓, 2,   PARP1↓, 1,   PCNA↓, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 3,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   Diff↑, 1,   FGF↑, 1,   IGF-1↑, 1,   Ki-67↓, 3,   MSCs↑, 1,   neuroG↑, 4,   p‑STAT1↓, 1,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 5,   AP-1↓, 5,   ARG1/2↑, 1,   BACH1↓, 1,   Ca+2↓, 5,   Ca+2↝, 1,   Cartilage↑, 5,   COL1↓, 2,   COL2A1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 2,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP1↓, 1,   MMP13↓, 3,   MMP2↓, 3,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 16,   MMP9↑, 1,   MMPs↓, 3,   MUC1↑, 2,   PAI-1/SERPINE1↓, 1,   Rho↓, 2,   ROCK1↓, 2,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   Snail↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 7,   TGF-β↑, 4,   TGF-β1↓, 1,   TGF-β1↑, 2,   TIMP1↓, 2,   TIMP2↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   Twist↑, 1,   TXNIP↓, 3,   TXNIP↑, 1,   Vim↓, 1,   Vim↑, 1,   Zeb1↓, 1,   α-SMA↓, 5,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   angioG↝, 1,   E-sel↓, 3,   eNOS↑, 2,   HIF-1↓, 1,   LOX1↓, 1,   NO↓, 39,   NO↑, 3,   VCAM-1↓, 10,   VEGF↓, 5,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 2,   BBB↑, 30,   BBB↝, 4,   BBB∅, 2,   CLDN1↓, 1,   CLDN1↑, 2,   CLDN3↑, 1,   CLDN4↑, 1,   GastroP↑, 3,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 5,   MMP↓, 1,   MMP↑, 18,   MUC19↓, 1,   MUC2↓, 1,   OCLN↓, 1,   OCLN↑, 5,   OCLN↝, 1,   TJ↑, 4,   TRPA1↑, 1,   TRPM7↓, 1,   TRPV1↑, 2,   VGSC↓, 1,   ZO-1↓, 2,   ZO-1↑, 9,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   AIM2↓, 2,   CB2 / CNR2↑, 4,   CD25+↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 7,   COX1↑, 1,   COX2/PTGS2↓, 82,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR4↓, 2,   DCells↑, 1,   FOXP3↑, 2,   HCAR2↑, 1,   HMGB1↓, 6,   ICAM-1↓, 13,   IFN-γ↓, 12,   IFN-γ↑, 2,   IL1↓, 2,   IL10↓, 9,   IL10↑, 25,   IL12↓, 5,   IL17↓, 10,   IL18↓, 11,   IL1α∅, 1,   IL1β↓, 235,   IL1β↑, 2,   IL1β∅, 1,   IL2↓, 5,   IL22↓, 1,   IL23↓, 2,   IL33↓, 2,   IL4↓, 7,   IL4↑, 3,   IL5↓, 2,   IL6?, 1,   IL6↓, 133,   IL6↑, 5,   IL8↓, 21,   IL8↑, 1,   IL8∅, 1,   Imm↑, 5,   INF-γ↓, 3,   Inflam↓, 166,   Inflam↑, 2,   IP-10/CXCL-10↓, 1,   IRF3↓, 4,   LPS↓, 2,   LTA/TNF-β↑, 1,   M1↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 13,   MCP1/CCL2↑, 1,   MCP1/CCL2∅, 1,   MIP‑1α/CCL3↓, 2,   MIP2↓, 2,   MyD88↓, 5,   NeuroI↓, 1,   NF-kB↓, 108,   p‑NF-kB↓, 1,   NLRP3↓, 38,   NOD1↓, 1,   p65↓, 3,   PGE2↓, 32,   PGE2↑, 1,   PSA↓, 1,   RAGE↓, 2,   RANTES↓, 3,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 6,   TLR4↓, 28,   TLR4↑, 1,   TNF-α↓, 197,   TNF-α↑, 1,   TRAF1↓, 1,   Treg lymp↝, 1,   TRIF↓, 3,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 10,   Ach↑, 11,   AChE↓, 31,   BChE↓, 7,   BDNF↑, 32,   BDNF∅, 2,   BrainVol↑, 1,   ChAT↑, 7,   ChE↓, 1,   DA↑, 1,   GABA↑, 2,   GABA↝, 1,   MAOA↓, 6,   MAOB↓, 2,   NGF↑, 3,   PSD95↑, 3,   SNAP25↑, 2,   SYP↑, 1,   TrkB↑, 5,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 7,   Aβ↓, 52,   Aβ42↓, 3,   BACE/β-secretase↓, 21,   tau↓, 11,   p‑tau↓, 13,   XO↓, 2,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   BNP↓, 1,   DHT↓, 1,   ER(estro)↓, 1,   GR↑, 1,   PPARα↑, 5,   PPARγ↓, 1,   PPARγ↑, 12,   p‑PPARγ↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 25,   BioAv↑, 40,   BioAv↝, 24,   BioEnh↑, 4,   CompStab↝, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 26,   eff↓, 5,   eff↑, 22,   eff↝, 2,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 5,   Half-Life↝, 12,   P-gp/ABCB1↓, 2,   P450↑, 1,   P450↝, 1,   Synergy↑, 15,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 19,   ALB↑, 1,   ALP↓, 4,   AST↓, 21,   BG↓, 2,   Bil↓, 1,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 1,   BP↓, 7,   BP∅, 1,   BUN?, 1,   BUN↓, 6,   CEA↓, 1,   creat↓, 9,   CRP↓, 9,   EGFR↓, 2,   Ferritin↑, 1,   Hcy/homoC↓, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 133,   IL6↑, 5,   LDH↓, 9,   NOS2↓, 3,   PSA↓, 1,   RAGE↓, 2,   SpO2↑, 1,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 4,   antiAll?, 1,   antiAll↑, 17,   AntiArt↑, 6,   AntiCan↑, 8,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 11,   antiPs↑, 2,   AntiTum↑, 2,   BOLD↑, 1,   cardioP?, 1,   cardioP↑, 41,   chemoP↑, 6,   chemoPv↑, 3,   cognitive↑, 60,   diuretic↑, 2,   hepatoP↑, 44,   Learn↑, 7,   memory↑, 53,   Mood↑, 1,   motorD↓, 2,   motorD↑, 14,   Mucositis↓, 1,   neuroP?, 1,   neuroP↑, 111,   NP/CIPN↓, 1,   Obesity↓, 5,   OS↑, 5,   Pain↓, 9,   PDE4↓, 1,   radioP↑, 7,   RenoP↓, 1,   RenoP↑, 24,   Risk↓, 6,   Sleep↑, 2,   Strength↑, 4,   Stress↓, 1,   Stroke↓, 15,   toxicity↓, 19,   toxicity↑, 1,   toxicity↝, 4,   toxicity∅, 8,   Weight↓, 1,   Weight↑, 2,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 9,   AntiFungal↑, 5,   AntiViral↑, 9,   Bacteria↓, 9,   Diar↓, 1,   GutMicro↑, 22,   GutMicro↝, 1,   Inf↓, 1,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr↝, 4,   Phen↑, 1,   QC↑, 1,  
Total Targets: 608

Scientific Paper Hit Count for: IL1β, interleukin-1 beta
18 Thymoquinone
12 Sulforaphane (mainly Broccoli)
10 Propolis -bee glue
10 Hydrogen Gas
10 Lycopene
10 Quercetin
9 Curcumin
7 Luteolin
7 Magnetic Fields
7 Silymarin (Milk Thistle) silibinin
6 Alpha-Lipoic-Acid
6 Resveratrol
6 Shikonin
6 Urolithin
5 Silver-NanoParticles
5 Beta-Caryophyllene
5 Chrysin
5 Crocetin
5 Hyperoside
4 Ashwagandha(Withaferin A)
4 Baicalein
4 Berberine
4 Radiotherapy/Radiation
4 Eugenol
4 Ferulic acid
4 Chemotherapy
4 Honokiol
4 Isoliquiritigenin
4 isoorientin
4 Matrine
4 Melatonin
4 Rosmarinic acid
4 Rutin
3 1,8-Cineole
3 α-Bisabolol / Chamomile oil
3 Carvacrol
3 Celastrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Chlorogenic acid
3 Cichoric acid / Chicoric acid
3 Dandelion Root
3 EGCG (Epigallocatechin Gallate)
3 Fisetin
3 Formononetin
3 Gallic acid
3 Isovitexin
3 Linalool
3 Piperine
3 Vitamin C (Ascorbic Acid)
2 Allicin (mainly Garlic)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Apigenin (mainly Parsley)
2 Artemisinin
2 Baicalin
2 Betulinic acid
2 borneol
2 Boron
2 Boswellia (frankincense)
2 Butyrate
2 Capsaicin
2 Thymol-Thymus vulgaris
2 Echinacea
2 D-limonene
2 Emodin
2 Cisplatin
2 Phosphatidylserine
2 Fucoidan
2 Ginkgo biloba
2 isoquercitrin
2 Lutein
2 5-fluorouracil
2 Magnolol
2 Methylsulfonylmethane
2 Phenylbutyrate
2 Piperlongumine
2 Pterostilbene
1 Anthocyanins
1 alpha Linolenic acid
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Atorvastatin
1 Aloe anthraquinones
1 Biochanin A
1 xanthohumol
1 Selenium
1 Bruteridin(bergamot juice)
1 Carnosic acid
1 Carnosine
1 chitosan
1 Chyawanprash
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Date Fruit Extract
1 Docosahexaenoic Acid
1 Dihydrocaffeic Acid
1 Vitamin A, Retinoic Acid
1 eicosapentaenoic acid
1 methotrexate
1 Folic Acid, Vit B9
1 Fenbendazole
1 Flaxseed/Linseed
1 Gamma-aminobutyric acid
1 Galloflavin
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 itraconazole
1 Kaempferol
1 Licorice
1 mebendazole
1 gefitinib, erlotinib
1 Magnetic Field Rotating
1 Magnesium
1 nicotinamide adenine dinucleotide
1 Vitamin B3,Niacin
1 Naringin
1 Nimbolide
1 Oleuropein
1 Oleocanthal
1 Psoralidin
1 Perilla
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Selenium NanoParticles
1 Sesame seeds and Oil
1 acetaminophen
1 Terpinen-4-ol / Tea Tree Oil
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 Vitamin K2
1 Vitexin
1 Zeaxanthin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:978  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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