Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱

Source:

Type: type of cell death

Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.

Scientific Papers found: Click to Expand⟱

4910-

Sal,

A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent

Apoptosis↑, CSCs↓, ChemoSen↑, RadioS↑, selectivity↑, Wnt↓, toxicity⇅,

5123-

Sal,

Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells

-

in-vitro,

BC,

MCF-7

-

in-vitro,

Pca,

PC3

-

in-vitro,

Pca,

DU145

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

Nor,

HEK293

Wnt↓, β-catenin/ZEB1↓, mTORC1↓, GSK‐3β↑, cycD1/CCND1↓, survivin↓, LRP6↓, TumCG↓, Apoptosis↑,

323-

Sal,

AgNPs,

Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy

-

in-vitro,

BC,

MDA-MB-231

 Sal (3 µM), AgNPs (4 µg/mL)

 IC25 values of both Sal and AgNPs (3.0 µM and 4 µg/mL)

-

in-vitro,

Ovarian,

A2780S

TumCD↑, LDH↓, MDA↑, SOD↓, ROS↑, GSH↓, Catalase↓, MMP↓, P53↑, P21↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Apoptosis↑, TumAuto↑,

1208-

SANG,

Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3 to the single-stranded DNA-binding protein 1 (SSBP1) promoter region

-

in-vitro,

OS,

NA

SSBP1↑, mtDam↑, Apoptosis↑, JAK↓, STAT3↓, PI3k/Akt/mTOR↓, ROS↑, MMP↓,

1307-

SANG,

Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway

-

in-vitro,

CRC,

HT-29

Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑,

5139-

SAS,

Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis

-

in-vitro,

OS,

MG63

-

in-vitro,

OS,

U2OS

*Inflam↓, TumCP↓, TumCMig↓, Apoptosis↑, Ferroptosis↑, Iron↑, MDA↑, ROS↑, GSH↓, SOD↓, MMP↓, NRF2↓, xCT↓, GPx4↓, FTH1↓,

5041-

SAS,

Cisplatin,

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

-

in-vitro,

CRC,

NA

xCT↓, Inflam↓, Apoptosis↓, GSH↓, ROS↑, TumCG↓, selectivity↑, eff↑, eff↓,

1388-

Sco,

Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells

-

in-vitro,

CRC,

NA

tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, BAX↑, Bcl-2↓, ROS↑, GSH↓, SOD↓, ER Stress↑, GRP78/BiP↑, CHOP↑, eff↓,

4483-

Se,

Chit,

Anti-cancer potential of chitosan-starch selenium Nanocomposite: Targeting osteoblastoma and insights of molecular docking

-

in-vitro,

OS,

NA

AntiCan↑, TumCP↓, Apoptosis↑, ROS↑, eff↑, other↝, eff↑, TumCCA↑,

4484-

Se,

Chit,

PEG,

Anti-cancer potential of selenium-chitosan-polyethylene glycol-carvacrol nanocomposites in multiple myeloma U266 cells

-

in-vitro,

Melanoma,

U266

tumCV↓, selectivity↑, ROS↑, MMP↓, Apoptosis↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,

4486-

Se,

Chit,

Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis

-

in-vitro,

Liver,

HepG2

Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,

4488-

Se,

Chit,

PEG,

Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats

-

in-vivo,

Liver,

HepG2

 size ranging from 390 to 450 nm

diethylnitrosamine (DEN)-induced liver cancer in rats

-

in-vivo,

Nor,

HL7702

tumCV↓, Apoptosis↑, *GSH↑, *VitC↑, *VitE↑, *SOD↑, *GPx↑, *GR↑, ALAT↓, ALP↓, AST↓, LDH↓, selectivity↑, eff↑,

4726-

Se,

Oxy,

Oxygen therapy accelerates apoptosis induced by selenium compounds via regulating Nrf2/MAPK signaling pathway in hepatocellular carcinoma

-

in-vivo,

HCC,

NA

tumor-bearing mice

eff↝, NRF2↓, p‑p38↑, Apoptosis↑, eff↑, TumVol↓, other↝, toxicity↓, Dose↝, NRF2↝, HO-1↓, Catalase↓, SOD↓, e-pH↓, pH∅, MAPK↑, eff↑,

4714-

Se,

SSE,

SeNPs,

Selenium in cancer management: exploring the therapeutic potential

-

Review,

Var,

NA

Risk↓, *BioAv↑, eff↝, *ROS↓, MMP↓, ROS↑, P53↑, *toxicity↓, TumCP↓, Casp↑, Apoptosis↑,

4734-

SeNPs,

CPT-11,

Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles

-

in-vitro,

CRC,

HCT8

-

in-vivo,

NA,

NA

chemoP↑, ChemoSen↑, P53↑, Apoptosis↑, TumCG↓, Casp↑, Dose↝, NRF2↓, selectivity↑, *NRF2↑,

4611-

SeNPs,

Rad,

Radioprotective Effect of Selenium Nanoparticles: A Mini Review

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *radioP↑, *ROCK1↓, *DNAdam↓, *Apoptosis↓, *RadioS↑, *Dose↝,

4480-

SeNPs,

Chit,

Biogenic synthesized selenium nanoparticles combined chitosan nanoparticles controlled lung cancer growth via ROS generation and mitochondrial damage pathway

-

in-vitro,

Lung,

A549

 55.285 and 30.9 nm, for SeNPs and Se-chitosan NPs, respectively.

Chito-NPs of 24.09 µg/mL, whereas for SeNPs it was 18.56 µg/mL

-

in-vitro,

Nor,

HK-2

selectivity↑, *toxicity↓, ROS↑, mtDam↑, Apoptosis↑, LDH↑,

4504-

SeNPs,

Chit,

FA,

doxoR,

pH-responsive selenium nanoparticles stabilized by folate-chitosan delivering doxorubicin for overcoming drug-resistant cancer cells

-

in-vitro,

Var,

NA

ChemoSen↑, Apoptosis↑, Casp3↑, PARP↝,

4501-

SeNPs,

Mechanisms of the Cytotoxic Effect of Selenium Nanoparticles in Different Human Cancer Cell Lines

-

in-vitro,

GBM,

A172

10ug/mL

-

in-vitro,

Colon,

Caco-2

-

in-vitro,

Pca,

DU145

3ug/mL

-

in-vitro,

BC,

MCF-7

10ug/mL

-

in-vitro,

Nor,

L929

*BioAv↑, selectivity↑, AntiCan↑, Apoptosis↑, CHOP↑, GADD34↑, BIM↑, PUMA↑, Ca+2↝,

4469-

SeNPs,

Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential

-

Review,

Var,

NA

antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,

4471-

SeNPs,

Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis

-

in-vitro,

Liver,

HepG2

stable SeNPs were prepared with an average size of 113 nm

eff↑, ROS↑, MMP↓, Casp9↑, Bcl-2↓, selectivity↑, Apoptosis↑,

4449-

SeNPs,

PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction

-

in-vitro,

Liver,

HepG2

PEG-SeNPs had Se cores about 5 nm in diameter, and the coated PEG gave them coronas and hydrodynamic diameters of about 28.7 nm

MMP↓, selectivity↑, Apoptosis↑, ROS↑,

4451-

SeNPs,

Effects of chitosan-stabilized selenium nanoparticles on cell proliferation, apoptosis and cell cycle pattern in HepG2 cells: comparison with other selenospecies

-

in-vitro,

Liver,

HepG2

*antiOx↑, Apoptosis↑, TumCCA↑,

4453-

SeNPs,

Selenium Nanoparticles: Green Synthesis and Biomedical Application

-

Review,

NA,

NA

*toxicity↓, *Bacteria↓, ROS↑, MMP↓, ER Stress↑, P53↑, Apoptosis↑, Casp9↑, DNAdam↑, TumCCA↑, eff↑, Catalase↓, SOD↓, GSH↓, selectivity↓, selectivity↑, PCNA↓, eff↑, *ALAT↓, *AST↓, *ALP↓, *creat↓, *Inflam↓, *toxicity↓, selectivity↑,

3180-

SFN,

Exploring the therapeutic effects of sulforaphane: an in-depth review on endoplasmic reticulum stress modulation across different disease contexts

-

Review,

Var,

NA

*cardioP↑, *ER Stress↓, GRP78/BiP↑, XBP-1↑, Apoptosis↑, *NRF2↑, UPR↑,

3181-

SFN,

Effect of sulforaphane on protein expression of Bip/GRP78 and caspase-12 in human hapetocelluar carcinoma HepG-2 cells

-

in-vitro,

HCC,

HepG2

GRP78/BiP↑, Casp12↑, Apoptosis↑, ER Stress↑,

2167-

SFN,

The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice

-

in-vitro,

PC,

MIA PaCa-2

-

in-vitro,

PC,

PANC1

Casp8↑, MMP↓, Casp3↑, Apoptosis↑, GSH↓, GSH↑,

2555-

SFN,

Chemopreventive functions of sulforaphane: A potent inducer of antioxidant enzymes and apoptosis

-

Review,

Var,

NA

chemoPv↑, HDAC↓, TumCCA↑, Apoptosis↑, Mets↑, *NRF2↑, ROS⇅,

2448-

SFN,

Sulforaphane and bladder cancer: a potential novel antitumor compound

-

Review,

Bladder,

NA

Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,

1014-

SFN,

Sulforaphane Modulates Cell Migration and Expression of β-Catenin and Epithelial Mesenchymal Transition Markers in Breast Cancer Cells

-

in-vitro,

BC,

MDA-MB-231

5, 10, 20, 30 and 40 μM

Zeb1↓, Apoptosis↑, Fibronectin↓, CLDN1↓, β-catenin/ZEB1↓, EMT↓,

1730-

SFN,

Sulforaphane: An emergent anti-cancer stem cell agent

-

Review,

Var,

NA

BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,

1733-

SFN,

Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal

-

in-vitro,

PC,

PanCSC

-

in-vitro,

Nor,

HPNE

-

in-vitro,

Nor,

HNPSC

CSCs↓, Shh↓, Gli↓, Nanog↓, OCT4↓, PDGFRA↓, cycD1/CCND1↑, Apoptosis↑, Casp↑, Smo↓, Gli1↓, GLI2↓, Bcl-2↓, Casp3↑, Casp7↑,

1735-

SFN,

Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane

-

in-vitro,

GBM,

T98G

 20 μM and 40 μM SFN for 24 h

-

in-vitro,

GBM,

U87MG

Apoptosis↑, Ca+2↑, Bax:Bcl2↑, cal2↑, Casp12↑, Casp9↑, Cyt‑c↑,

1723-

SFN,

Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review

-

Review,

Var,

NA

*NRF2↑, ROS↑, MMP↓, Cyt‑c↑, cl‑PARP↑, Apoptosis↑, AMPK↑, GSH↓,

1722-

SFN,

Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems

-

Review,

Var,

NA

TumCCA↑, CYP1A1↓, CYP3A4↓, Cyt‑c↑, Casp9↑, Apoptosis↑, ROS↑, MAPK↑, P53↑, BAX↑, ChemoSen↑, HDAC↓, GSH↓, HO-1↑,

1498-

SFN,

Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells

-

in-vitro,

CRC,

HCT116

-

in-vitro,

Nor,

NCM460

selectivity↑, TumCCA↑, Apoptosis↑, *p‑ERK↑, cMYB↓, selectivity↑, selectivity↑,

1459-

SFN,

AF,

Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway

-

in-vitro,

Liver,

Hep3B

 auranofin (0.5, 1, 1.5, and 2 μM) or sulforaphane (2.5, 5, 7.5, and 10 μM)

-

in-vitro,

Liver,

HepG2

eff↑, TumCCA↑, Apoptosis↑, MMP↓, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, ROS↑, eff↓, PI3K↓, Akt↓, TrxR↓, BAX↑, Bcl-2∅,

1471-

SFN,

ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells

-

in-vitro,

GC,

AGS

TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↑, P21↑, p‑H3↑, p‑AMPK↑, eff↓, MMP↓, Cyt‑c↑, ROS↑, eff↓,

1467-

SFN,

Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells

-

in-vitro,

AML,

U937

Apoptosis↑, ROS↑, MMP↓, Casp3↑, Bcl-2↓, eff↓,

1466-

SFN,

Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway

-

vitro+vivo,

Thyroid,

FTC-133

10.8 to 19.6 μM

mice

TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, Slug↓, Twist↓, MMP2↓, MMP9↓, TumCG↓, p‑Akt↓, P21↑, ERK↑, p38↑, ROS↑, *toxicity∅, MMP↓, eff↓,

1465-

SFN,

TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells

-

NA,

Bladder,

NA

eff↑, Apoptosis↑, Casp↑, MMP↓, BID↑, DR5↑, ROS↑, NRF2↑, eff↑, eff↓,

1464-

SFN,

d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway

-

in-vitro,

GBM,

NA

Apoptosis↑, Casp3↑, BAX↑, Bcl-2↓, ROS↑, p‑STAT3↓, JAK2↓, eff↓,

1463-

SFN,

Sulforaphane induces reactive oxygen species-mediated mitotic arrest and subsequent apoptosis in human bladder cancer 5637 cells

-

in-vitro,

Bladder,

5637

tumCV↓, CycB/CCNB1↑, p‑CDK1↑, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, ROS↑, eff↓,

1461-

SFN,

Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer - contradictory effects and future perspectives

-

Review,

BC,

NA

TumCP↓, Apoptosis↑, TumCCA↑, antiOx↑,

1434-

SFN,

GEM,

Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity

-

in-vitro,

CCA,

HuCCT1

 SFN (0–80 μM) or GEM (0–10 μM) for 24 h

27.4uM(SFN),0.57 μM(GEM)

-

in-vitro,

CCA,

HuH28

34.2 μM(SFN), 0.71um(GEM)

-

in-vivo,

NA,

NA

50 mg/kg/day

tumors of SFN- and GEM-treated mice

HDAC↓, ac‑H3↑, ChemoSen↑, tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, TumCI↓, VEGF↓, VEGFR2↓, Hif1a↓, eNOS↓, EMT?, TumCG↓, Ki-67↓, TUNEL↑, P21↑, p‑Chk2↑, CDC25↓, BAX↑, *ROS↓, NQO1?,

1474-

SFN,

Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway

-

in-vitro,

Colon,

SW480

5, 10, 15 and 20 µM

TumCG↓, Apoptosis↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp7↑, Casp9↑, ROS↑, e-ERK↑, p38↑, P53∅, eff↓, ChemoSen↑,

1509-

SFN,

Combination therapy in combating cancer

-

Review,

NA,

NA

NRF2↑, ChemoSideEff↓, eff↑, TumCP↓, Apoptosis↑, TumCCA↑, eff↑, PSA↓, P53↑, Hif1a↓, CAIX↓, chemoR↓, 5HT↓,

1497-

SFN,

Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells

-

in-vitro,

Nor,

PrEC

-

in-vitro,

Pca,

LNCaP

15 µM SFN

-

in-vitro,

Pca,

PC3

HDAC↓, selectivity↑, TumCCA↑, Apoptosis↑, selectivity↑, H3↑, P21↑, selectivity↑,

1482-

SFN,

Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway

-

in-vitro,

Bladder,

T24/HTB-9

tumCV↓, Apoptosis↑, Cyt‑c↑, Bax:Bcl2↑, Casp9↑, Casp3↑, Casp8∅, cl‑PARP↑, ROS↑, MMP↓, eff↓, ER Stress↑, p‑NRF2↑, HO-1↑,

1480-

SFN,

Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells

-

in-vitro,

CRC,

HCT116

tumCV↓, TumCCA↑, Apoptosis↑, cycA1/CCNA1↑, CycB/CCNB1↑, CDC25↓, CDK1↓, ROS↑, eff↓, Cyt‑c↑, AIF↑, ER Stress↑,

Showing Research Papers: 951 to 1000 of 1153
Prev Page 20 of 24 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1153

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 2, Catalase↓, 3, CYP1A1↓, 1, Ferroptosis↑, 1, GPx4↓, 1, GSH↓, 8, GSH↑, 1, GSTA1↑, 1, HO-1↓, 1, HO-1↑, 2, Iron↑, 1, MDA↑, 2, Mets↑, 1, NQO1?, 1, NRF2↓, 3, NRF2↑, 4, NRF2↝, 1, p‑NRF2↑, 1, mt-OXPHOS↓, 1, ROS↑, 28, ROS⇅, 1, SOD↓, 5, TrxR↓, 1, xCT↓, 2,

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

AIF↑, 2, ATP↓, 1, CDC25↓, 2, MMP↓, 20, mtDam↑, 2, SSBP1↑, 1,

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1, ALAT↓, 1, AMPK↑, 1, p‑AMPK↑, 1, CAIX↓, 1, CYP3A4↓, 1, glucoNG↓, 1, Glycolysis↓, 1, HK2↓, 1, LDH↓, 2, LDH↑, 1, PI3k/Akt/mTOR↓, 1,

Cell Death ⓘ

Akt↓, 1, p‑Akt↓, 1, Apoptosis↓, 1, Apoptosis↑, 48, BAX↑, 11, Bax:Bcl2↑, 3, Bcl-2↓, 9, Bcl-2∅, 1, BID↑, 1, BIM↑, 1, Casp↑, 4, Casp12↑, 2, Casp3↑, 16, cl‑Casp3↑, 2, Casp7↑, 4, Casp8↑, 4, Casp8∅, 1, Casp9↑, 13, cl‑Casp9↑, 1, p‑Chk2↑, 1, Cyt‑c↓, 1, Cyt‑c↑, 9, DR5↑, 1, FADD↑, 1, Fas↑, 1, FasL↑, 1, Ferroptosis↑, 1, GADD34↑, 1, hTERT/TERT↓, 1, MAPK↑, 2, p27↑, 1, p38↑, 2, p‑p38↑, 1, PUMA↑, 1, survivin↓, 2, TumCD↑, 1, TUNEL↑, 1,

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,

Transcription & Epigenetics ⓘ

H3↑, 1, p‑H3↑, 1, ac‑H3↑, 1, HATs↓, 1, other↝, 2, tumCV↓, 7,

Protein Folding & ER Stress ⓘ

CHOP↑, 2, ER Stress↑, 5, GRP78/BiP↑, 3, UPR↑, 1, XBP-1↑, 1,

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

DNAdam↑, 3, DNMT1↓, 1, DNMT3A↓, 1, P53↑, 6, P53∅, 1, PARP↝, 1, cl‑PARP↑, 5, PCNA↓, 1,

Cell Cycle & Senescence ⓘ

CDK1↓, 1, CDK1↑, 1, p‑CDK1↑, 1, cycA1/CCNA1↑, 1, CycB/CCNB1↑, 3, cycD1/CCND1↓, 1, cycD1/CCND1↑, 2, P21↑, 6, TumCCA↑, 17,

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1, ALDH1A1↓, 1, CD133↓, 1, CD44↓, 1, cMYB↓, 1, CSCs↓, 3, EMT?, 1, EMT↓, 4, ERK↑, 1, e-ERK↑, 1, Gli↓, 1, Gli1↓, 2, GSK‐3β↑, 1, HDAC↓, 6, LRP6↓, 1, mTORC1↓, 1, Nanog↓, 2, NOTCH↓, 1, OCT4↓, 2, PDGFRA↓, 1, PI3K↓, 1, Shh↓, 2, Smo↓, 2, STAT3↓, 1, p‑STAT3↓, 1, TumCG↓, 9, Wnt↓, 3,

Migration ⓘ

Ca+2↑, 1, Ca+2↝, 1, cal2↑, 1, CLDN1↓, 1, Fibronectin↓, 1, GLI2↓, 1, Ki-67↓, 1, MMP2↓, 3, MMP9↓, 2, Slug↓, 1, Snail↓, 1, TumCI↓, 3, TumCMig↓, 2, TumCP↓, 8, TumMeta↓, 2, Twist↓, 1, Zeb1↓, 2, β-catenin/ZEB1↓, 2,

Angiogenesis & Vasculature ⓘ

angioG↓, 1, EGFR↓, 1, eNOS↓, 1, Hif1a↓, 3, VEGF↓, 1, VEGFR2↓, 1,

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, IL1β↓, 1, Inflam↓, 1, JAK↓, 1, JAK2↓, 1, NF-kB↓, 1, PSA↓, 1, TNF-α↓, 1,

Cellular Microenvironment ⓘ

pH∅, 1, e-pH↓, 1,

Synaptic & Neurotransmission ⓘ

Drug Metabolism & Resistance ⓘ

BioAv↓, 1, BioAv↑, 1, BioAv↝, 2, chemoR↓, 1, ChemoSen↑, 9, Dose↝, 3, eff↓, 13, eff↑, 15, eff↝, 2, P450↓, 1, RadioS↑, 2, selectivity↓, 1, selectivity↑, 18,

Clinical Biomarkers ⓘ

ALAT↓, 1, ALP↓, 1, AST↓, 1, EGFR↓, 1, HER2/EBBR2↓, 1, hTERT/TERT↓, 1, Ki-67↓, 1, LDH↓, 2, LDH↑, 1, PSA↓, 1,

Functional Outcomes ⓘ

AntiCan↑, 3, AntiTum↑, 2, chemoP↑, 1, chemoPv↑, 1, ChemoSideEff↓, 1, Risk↓, 2, toxicity↓, 1, toxicity⇅, 1, TumVol↓, 1,
Total Targets: 205

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 2, GPx↑, 1, GSH↑, 1, NRF2↑, 4, ROS↓, 2, SOD↑, 1, VitC↑, 1, VitE↑, 1,

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Apoptosis↓, 1,

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,

DNA Damage & Repair ⓘ

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1, HDAC↓, 1, HDAC3↓, 1,

Migration ⓘ

Ki-67↓, 1, ROCK1↓, 1,

Immune & Inflammatory Signaling ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

BioAv↑, 3, Dose↝, 1, RadioS↑, 1,

Clinical Biomarkers ⓘ

ALAT↓, 1, ALP↓, 1, AST↓, 1, creat↓, 1, Ki-67↓, 1,

Functional Outcomes ⓘ

cardioP↑, 1, radioP↑, 1, toxicity↓, 5, toxicity↑, 1, toxicity∅, 1,

Infection & Microbiome ⓘ

Bacteria↓, 1,
Total Targets: 33

Scientific Paper Hit Count for: Apoptosis, Apoptosis

67 Silver-NanoParticles
61 Curcumin
43 Magnetic Fields
41 Quercetin
36 Thymoquinone
34 Berberine
31 Sulforaphane (mainly Broccoli)
29 Baicalein
29 EGCG (Epigallocatechin Gallate)
25 Ashwagandha(Withaferin A)
25 Shikonin
23 Betulinic acid
23 Phenethyl isothiocyanate
21 Resveratrol
19 Artemisinin
19 Radiotherapy/Radiation
19 Apigenin (mainly Parsley)
19 Boron
19 Selenite (Sodium)
18 Honokiol
18 Lycopene
18 Urolithin
17 Garcinol
14 Chemotherapy
14 Astaxanthin
14 Luteolin
13 salinomycin
13 Magnolol
12 Allicin (mainly Garlic)
12 Chrysin
12 Graviola
11 chitosan
11 Propolis -bee glue
11 Silymarin (Milk Thistle) silibinin
11 Gambogic Acid
11 Selenium NanoParticles
10 Cisplatin
10 Vitamin C (Ascorbic Acid)
10 Alpha-Lipoic-Acid
10 Phenylbutyrate
10 Piperlongumine
9 Capsaicin
9 Fisetin
9 Juglone
9 Nimbolide
9 Rosmarinic acid
8 Photodynamic Therapy
8 Coenzyme Q10
8 Auranofin
8 Copper and Cu NanoParticles
8 Metformin
8 Paclitaxel
8 Bufalin/Huachansu
8 Selenium
8 Ursolic acid
8 Dichloroacetate
8 Magnetic Field Rotating
7 5-fluorouracil
7 Atorvastatin
7 Biochanin A
7 borneol
7 Boswellia (frankincense)
7 Caffeic acid
7 Electrical Pulses
7 Emodin
7 HydroxyTyrosol
7 Vitamin K2
6 Astragalus
6 Andrographis
6 Gemcitabine (Gemzar)
6 doxorubicin
6 Citric Acid
6 Ellagic acid
6 Hydrogen Gas
6 Piperine
6 Parthenolide
5 immunotherapy
5 Melatonin
5 Aflavin-3,3′-digallate
5 Genistein (soy isoflavone)
5 Plumbagin
5 Pterostilbene
4 3-bromopyruvate
4 Gold NanoParticles
4 Ascorbyl Palmitate
4 Berbamine
4 Brucea javanica
4 Bacopa monnieri
4 Bromelain
4 Butyrate
4 Disulfiram
4 Ferulic acid
4 Ginkgo biloba
4 γ-linolenic acid (Borage Oil)
4 Spermidine
3 2-DeoxyGlucose
3 Baicalin
3 brusatol
3 Bruteridin(bergamot juice)
3 Date Fruit Extract
3 diet FMD Fasting Mimicking Diet
3 Galloflavin
3 Orlistat
3 Hyperthermia
3 Magnesium
3 Naringin
3 Niclosamide (Niclocide)
3 Sanguinarine
3 Psoralidin
3 Taurine
3 VitK3,menadione
3 Zerumbone
2 5-Aminolevulinic acid
2 Fenbendazole
2 Ajoene (compound of Garlic)
2 alpha Linolenic acid
2 Dipyridamole
2 Aloe anthraquinones
2 beta-glucans
2 tamoxifen
2 Docetaxel
2 Bortezomib
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Deguelin
2 diet Short Term Fasting
2 Folic Acid, Vit B9
2 Fucoidan
2 Shilajit/Fulvic Acid
2 Ginger/6-Shogaol/Gingerol
2 HydroxyCitric Acid
2 Methylglyoxal
2 Oleuropein
2 Oleocanthal
2 Oxygen, Hyperbaric
2 Propyl gallate
2 Rutin
2 Sulfasalazine
2 polyethylene glycol
2 Vitamin D3
1 cetuximab
1 5-Hydroxytryptophan
1 Glucose
1 entinostat
1 Trichostatin A
1 Radio Frequency
1 Acetyl-l-carnitine
1 Amodiaquine
1 temozolomide
1 Aspirin -acetylsalicylic acid
1 Sorafenib (brand name Nexavar)
1 Trastuzumab
1 almonertinib
1 epirubicin
1 Lapatinib
1 bempedoic acid
1 Bifidobacterium
1 Carvacrol
1 Cannabidiol
1 Selenate
1 Prebiotic
1 Cinnamon
1 Vitamin E
1 Crocetin
1 chemodynamic therapy
1 methylseleninic acid
1 Dichloroacetophenone(2,2-)
1 diet Methionine-Restricted Diet
1 Evodiamine
1 Exercise
1 Gallic acid
1 carboplatin
1 gefitinib, erlotinib
1 Grapeseed extract
1 hydrogen sulfide
1 Rapamycin
1 Huperzine A/Huperzia serrata
1 Indole-3-carbinol
1 Inoscavin A
1 Ivermectin
1 Licorice
1 Lutein
1 Iron
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Mushroom Lion’s Mane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Proanthocyanidins
1 isoflavones
1 Vorinostat
1 Oxaliplatin
1 Scoulerine
1 irinotecan
1 acetazolamide
1 Osimertinib
1 Adagrasib
1 Glutathione
1 Tomatine
1 Docosahexaenoic Acid
1 Vitamin B3,Niacin
1 Whole Body Vibration
1 xanthohumol
1 Zinc Oxide

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Home Page