Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5374- ATO,    A pharmacokinetic and safety study of oral arsenic trioxide in patients with acute promyelocytic leukemia
- Trial, APL, NA
toxicity↓, OS↑,
5454- ATV,    Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility
- Review, BC, NA
HMG-CoA↓, HMGCR↓, TumCP↓, RadioS↑, CD44↓, P53↑,
5453- ATV,    Epidemiologic Analysis Along the Mevalonate Pathway Reveals Improved Cancer Survival in Patients Who Receive Statins Alone and in Combination With Bisphosphonates
- Trial, Var, NA
OS↑, eff↑, other↝,
5452- ATV,    Mevalonate pathway in pancreatic ductal adenocarcinoma: mechanisms driving metabolic and cellular plasticity
- Review, Var, NA
ChemoSen↑, HMG-CoA↓, EMT↓, Ferroptosis↑, Hif1a↓,
5451- ATV,    In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, GBM, U87MG - in-vitro, GBM, A172
TumAuto↑, CSCs↓, HMG-CoA↓, TumCP↓, tumCV↓, TumCCA↑, TumCG↓, HMGCR↓,
5450- ATV,    The Mevalonate Pathway in the Radiation Response of Cancer
- vitro+vivo, Var, NA
eff↑, RadioS↑,
5448- ATV,    Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, eff↑, HMGCR↓, LDL↓, cardioP↑, AntiTum↑, ChemoSen↑, RadioS↑, toxicity↓,
5447- ATV,    The Mevalonate Pathway, a Metabolic Target in Cancer Therapy
- Review, Var, NA
Risk↓, Dose↑, ChemoSen↑, chemoP↑, HMG-CoA↓, EMT↓, CSCs↓, HH↝, YAP/TEAD↝,
5446- ATV,    Targeting the Mevalonate Pathway in Cancer
- Review, Var, NA
EMT↓, HMG-CoA↓,
5445- ATV,    Atorvastatin
- NA, Nor, NA
*cardioP↑, *LDL↓, HMG-CoA↓, Half-Life↝, BioAv↓, Dose↝,
5449- ATV,    Pleiotropic effects of statins: A focus on cancer
- NA, Var, NA
lipid-P↓, TumCG↓, Apoptosis↑, ChemoSen↑, RAS↓, HMG-CoA↓, HMGCR↓, LDL↓, toxicity↓, Risk↓, P21↑, HDAC↓, Bcl-2↓, BAX↑, BIM↑, Casp↑, cl‑PARP↑, MMP↓, ROS↑, angioG↓, TumMeta↓, PTEN↑, eff↑, OS↑, Remission↑,
4982- ATV,    Inhibiting the mevalonate pathway with atorvastatin alters gut microbiota and has potential as an anti-cancer treatment for ovarian cancer
- in-vivo, Ovarian, NA
HMG-CoA↓, GutMicro↑,
4981- ATV,    Crosstalk between Statins and Cancer Prevention and Therapy: An Update
Apoptosis↑, selectivity↑, eff↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,
4980- ATV,    A review of effects of atorvastatin in cancer therapy
- Review, Var, NA
HMG-CoA↓, TumCP↓, TumCMig↓,
4979- ATV,  Rad,    Short‐Term Statin Treatment Reduces, and Long‐Term Statin Treatment Abolishes, Chronic Vascular Injury by Radiation Therapy
- in-vivo, Nor, NA
radioP↑, radioP↑,
4978- ATV,  Rad,    Atorvastatin Sensitizes Breast and Lung Cancer Cells to Ionizing Radiation
- in-vitro, BC, A549
Apoptosis↑, RadioS↑, TumCP↓, ROS↑,
4988- ATV,  Dipy,    Repurposing of the Cardiovascular Drug Statin for the Treatment of Cancers: Efficacy of Statin–Dipyridamole Combination Treatment in Melanoma Cell Lines
- in-vivo, Melanoma, NA
HMGCR↓, SREBP2↑, SREBP2↓, AntiAg↑,
4985- ATV,  Dipy,    Repurposing of the Cardiovascular Drug Statin for the Treatment of Cancers: Efficacy of Statin-Dipyridamole Combination Treatment in Melanoma Cell Lines
- in-vivo, Melanoma, SK-MEL-28 - in-vitro, BC, MDA-MB-435
HMG-CoA↓, SREBP2↓, eff↑, HMGCR⇅, ChemoSen↑,
4986- ATV,  Dipy,    The combination of statins and dipyridamole is effective preclinically in AML, MM, and breast cancer
- Review, Var, NA
HMG-CoA↓, AntiAg↑, eff↑, Apoptosis↑, selectivity↑, *toxicity↓, TumCG↓, PDE4↓, other↑,
1302- AV,    Quantitative measurement of Bax and Bcl2 genes and protein expression in MCF7 cell-line when treated by Aloe Vera extract
- in-vitro, BC, MCF-7
BAX↑, Bcl-2↓,
5368- AV,    Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms
- Trial, HNSCC, NA
radioP↝,
5362- AV,    Anti-cancer effects of aloe-emodin: a systematic review
- Review, Var, NA
AntiCan↑, eff↝, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumCD↑, MMP↓, ROS↑, Apoptosis↑, CDK1↓, CycB/CCNB1↓, Bcl-2↓, PCNA↓, ATP↓, ER Stress↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, MMP2↓, Ca+2↑, DNAdam↑, Akt↓, PKCδ↓, mTORC2↓, GSH↓, ChemoSen↑,
5363- AV,    Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments
- Study, HCC, NA
AKT1↓, EGFR↓, PI3K↓, Bcl-2↓, TumCG↓, Apoptosis↑,
5364- AV,    A New Biomaterial Derived from Aloe vera—Acemannan from Basic Studies to Clinical Application
- Review, Var, NA
BioAv↑, AntiTum↑, cardioP↑,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
5366- AV,    Aloe vera: A review of toxicity and adverse clinical effects
- Review, Var, NA
*Dose↝, *toxicity↝, tumCV↓, *AntiAg↑,
5367- AV,  Rad,    Aloe vera for prevention of radiation-induced dermatitis: a self-controlled clinical trial
- Trial, Var, NA
radioP↑, Dose↝, eff↑,
5369- AV,    Assessment of Anticancer Effects of Aloe vera on 3D Liver Tumor Spheroids in a Microfluidic Platform
- in-vitro, Liver, HepG2
tumCV↓, AntiCan↑, P53↑, Bcl-2↓,
5370- AV,    The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial
- Trial, AML, NA
Dose↝, stomatitis↓, Pain↓,
5371- AV,    Assessment of the immunomodulatory effect of Aloe vera polysaccharides extracts on macrophages functions
- Study, Nor, NA
*eff↑, *IL6↑, *toxicity↓, *Imm↑,
5581- B-Gluc,    Chemo-Immunotherapy Using Lentinan for the Treatment of Gastric Cancer with Liver Metastases
- Human, GC, NA
OS↑,
5572- B-Gluc,    The Effects of Orally Administered Beta-Glucan on Innate Immune Responses in Humans, a Randomized Open-Label Intervention Pilot-Study
- Study, Nor, NA
Imm↑, *Dose↝, *BioAv↓, *toxicity↑,
5571- B-Gluc,  immuno,    Potential benefit of β-glucans as adjuvant therapy in immuno-oncology: a review
- Review, Var, NA
Imm↑, ChemoSen↑, LDL↑, GutMicro↑, TumCP↓, Apoptosis↑, angioG↓, QoL↑,
5570- B-Gluc,    Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1
- Review, Var, NA
Imm↑, BioAv↝, eff↑, AntiCan↑, Dectin1↝, Dose↝, BioAv↓,
5569- B-Gluc,    Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response
- in-vitro, CRC, NA
Imm↑,
5568- B-Gluc,  immuno,    Beta-glucans in oncology: revolutionizing treatment with immune power & tumor targeting
- Review, Var, NA
TNF-α↓, IL6↓, NF-kB↓, PD-L1↓, Imm↑, BAX↑, Bcl-2↓, TumCCA↑, angioG↓, VEGF↓, MMPs↓, OS↑, chemoP↑, eff↑, BioAv↑,
5567- B-Gluc,    Trained immunity: A new player in cancer immunotherapy
- Review, Var, NA
Imm↑, ROS↑, Apoptosis↑, OS↑, TumMeta↓, Dose↝,
5566- B-Gluc,    The effects of beta-glucan on human immune and cancer cells
- Review, Var, NA
Imm↑, *BioAv↓, OS↑, ChemoSen↑,
5573- B-Gluc,    Continuous Exposure to Non-Soluble β-Glucans Induces Trained Immunity in M-CSF-Differentiated Macrophages
- in-vitro, Nor, NA
*Dectin1↑, *Imm↑, *TNF-α↓,
5574- B-Gluc,    Beta Glucan: Health Benefits in Obesity and Metabolic Syndrome
- Review, Obesity, NA
*BioAv↑, *toxicity↓, *Imm↑, *eff↑, *Risk↓, *Weight↓, *eff↝, *BP↓, *GutMicro↑, *eff↓,
5575- B-Gluc,    The effects of β-glucan on human immune and cancer cells
- Review, Var, NA
Imm↑, *toxicity↓, eff↑, Imm↑,
5576- B-Gluc,  Chemo,    Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy
- Trial, GC, NA
OS↑, eff↑,
5577- B-Gluc,    Lentinan progress in inflammatory diseases and tumor diseases
- Review, Var, NA - Review, IBD, NA
AntiTum↑, GutMicro↑, *Inflam↓, *TNF-α↓, *NF-kB↓, ChemoSen↑, OS↑, Imm↑, IL6↓, ERK↓, MAPK↓, *antiOx↑, eff↑,
5578- B-Gluc,    A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group
- Trial, GC, NA
OS↑, QoL↑,
5579- B-Gluc,    Fungal beta-glucans as adjuvants for treating cancer patients – A systematic review of clinical trials
- Review, Var, NA
*toxicity↓, Imm↑, radioP↑, chemoP↑,
5580- B-Gluc,    Lentinan, a Shiitake Mushroom β-Glucan, Downregulates the Enhanced PD-L1 Expression Induced by Platinum Compounds in Gastric Cancer Cells
- in-vitro, GC, MKN45
PD-L1↓, MAPK↓, OS↑, AntiTum↑, Imm↑,
874- B-Gluc,    Potential promising anticancer applications of β-glucans: a review
- Review, NA, NA
AntiCan↑, TumCG↓, BAX↑, Bcl-2↓, IFN-γ↑, PI3K/Akt↑, MAPK↑, NFAT↑, NF-kB↑, ROS↑, NK cell↑, TumCCA↑, ERK↓, Telomerase↓,
875- B-Gluc,    Chemistry, physico-chemistry and applications linked to biological activities of β-glucans
- Review, NA, NA
AntiCan↑,
876- B-Gluc,    Clinical and Physiological Perspectives of β-Glucans: The Past, Present, and Future
- Review, NA, NA
AntiTum↑,
996- Ba,  Tam,    Baicalein resensitizes tamoxifen‐resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia‐inducible factor‐1α
Hif1a↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, lact/pyru↓, ROS↑, Apoptosis↑,

Showing Research Papers: 1001 to 1050 of 5772
Prev Page 21 of 116 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5772

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GSH↓, 1,   lipid-P↓, 1,   ROS↑, 6,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   Histones↝, 1,   HMG-CoA↓, 12,   lact/pyru↓, 1,   lactateProd↓, 1,   LDL↓, 2,   LDL↑, 1,   PI3K/Akt↑, 1,   SREBP2↓, 2,   SREBP2↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 10,   BAX↑, 4,   Bcl-2↓, 7,   BIM↑, 1,   Casp↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Ferroptosis↑, 1,   MAPK↓, 2,   MAPK↑, 1,   Telomerase↓, 1,   TumCD↑, 1,   YAP/TEAD↝, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,   other↑, 1,   other↝, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 3,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 2,   cl‑PARP↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   P21↑, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   CSCs↓, 2,   EMT↓, 3,   ERK↓, 2,   HDAC↓, 2,   HH↝, 1,   HMGCR↓, 5,   HMGCR⇅, 1,   mTORC2↓, 1,   PI3K↓, 1,   PTEN↑, 1,   RAS↓, 1,   TumCG↓, 5,  

Migration ⓘ

AntiAg↑, 2,   Ca+2↑, 1,   MMP2↓, 1,   MMPs↓, 2,   NFAT↑, 1,   PKCδ↓, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 6,   TumMeta↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   EGFR↓, 1,   Hif1a↓, 2,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

Dectin1↝, 1,   IFN-γ↑, 1,   IL1β↓, 1,   IL6↓, 3,   IL8↓, 1,   Imm↑, 12,   NF-kB↓, 1,   NF-kB↑, 1,   NK cell↑, 2,   PD-L1↓, 2,   TNF-α↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 9,   Dose↑, 1,   Dose↝, 5,   eff↑, 13,   eff↝, 1,   Half-Life↝, 1,   RadioS↑, 4,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   GutMicro↑, 3,   IL6↓, 3,   PD-L1↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 5,   AntiTum↑, 6,   cardioP↑, 2,   chemoP↑, 3,   OS↑, 12,   Pain↓, 1,   PDE4↓, 1,   QoL↑, 2,   radioP↑, 4,   radioP↝, 1,   Remission↑, 1,   Risk↓, 2,   stomatitis↓, 1,   toxicity↓, 3,  

Infection & Microbiome ⓘ

Dectin1↝, 1,  
Total Targets: 117

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx↑, 1,   lipid-P↓, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDL↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Dectin1↑, 1,   IL10↑, 1,   IL1β↓, 1,   IL6↓, 1,   IL6↑, 1,   Imm↑, 4,   Inflam↓, 2,   NF-kB↓, 2,   TNF-α↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 2,   eff↝, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   GutMicro↑, 2,   IL6↓, 1,   IL6↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 2,   Risk↓, 1,   toxicity↓, 5,   toxicity↑, 1,   toxicity↝, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Dectin1↑, 1,  
Total Targets: 42

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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