TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱
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Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.
Scientific Papers found: Click to Expand⟱
52- QC,    Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell Lines
- in-vitro, BC, MCF7 - in-vitro, Ovarian, SKOV3 - in-vitro, OS, U2OS
Bcl-2↓, BAX↑, PI3K/Akt↓, cycD1/CCND1↓, TumCCA↑,
94- QC,  HPT,    Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, JCA-1
HSP70/HSPA5↓, TumCCA↑, TumCG↓, Synergy↑,
91- QC,    The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells
- in-vitro, Pca, PC3
CDK2↓, cycE/CCNE↓, cycD1/CCND1↓, ATFs↑, GRP78/BiP↑, Bcl-2↓, BAX↑, Casp3↑, Casp8↑, Casp9↑, ER Stress↑, CHOP/DDIT3↑, TumCCA↑, DNAdam↑, AIF↑, Ca+2↑, MMP↓,
88- QC,  PacT,    Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production
- vitro+vivo, Pca, PC3
ROS↑, ER Stress↑, TumCP↓, Apoptosis↑, TumCCA↑, TumCMig↓, GRP78/BiP↑, CHOP/DDIT3↑, TumCG↓,
84- QC,    Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression
- in-vitro, Pca, PC3
P21↑, cDC2↓, CDK1↓, CycB/CCNB1↓, Casp3↑, Bcl-2↓, Bcl-xL↓, BAX↑, pRB↓, TumCCA↑, Apoptosis↑,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4/6↓, E2Fs↓, PCNA↓, cDC2↓, PTEN↑, MSH2↑, P21↑, EP300↑, BRCA1↑, NF2↑, TSC1↑, TGFβR1↑, P53↑, RB1↑, AKT1↓, cMyc↓, CDC7↓, cycF↓, CDC16↓, CUL4B↑, CBP↑, TSC2↑, HER2/EBBR2↓, BCR↓, TumCCA↑, chemoPv↑,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
- Review, Var, NA
tumCV↓, Apoptosis↑, PI3k/Akt/mTOR↓, Wnt/(β-catenin)↓, MAPK↝, ERK↝, TumCCA↑, H2O2↑, ROS↑, TumAuto↑, MMPs↓, P53↑, Casp3↑, Hif1a↓, cFLIP↓, IL6↓, IL10↓, lactateProd↓, Glycolysis↓, PKM2↓, GLUT1↓, COX2/PTGS2↓, VEGF↓, OCR↓, ECAR↓, STAT3↓, MMP2↓, MMP9:TIMP1↓, mTOR↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
914- QC,    Quercetin and Cancer Chemoprevention
- Review, Var, NA
GSH↓, ROS↑, TumCCA↑, Ca+2↑, MMP↓, Casp3↑, Casp8↑, Casp9↑, β-catenin/ZEB1↓, AMPKα↑, ASK1↑, p38↑, TRAIL↑, DR5↑, cFLIP↓, Apoptosis↑,
913- QC,    Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression
- in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-435
TumCP↓, TumCCA↑, DNAdam↑, Chk2↑, CycB/CCNB1↓, CDK1↓, tumCV↓, p‑RB1↓, P21↑,
4666- RES,    Structural modification of resveratrol analogue exhibits anticancer activity against lung cancer stem cells via suppression of Akt signaling pathway
- in-vitro, Lung, H23 - in-vitro, Lung, H292 - in-vitro, Lung, A549
CSCs↓, eff↑, Akt↓, GSK‐3β↑, SOX2↓, cMyc↓, TumCCA↑, ROS↑, Apoptosis↑,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
882- RES,    Resveratrol: A Double-Edged Sword in Health Benefits
- Review, Var, NA
AntiTum↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↑, NAF1↓, NRF2↑, ROS↑, Apoptosis↑, HDAC↓, TumCCA↑, TumAuto↑, angioG↓, iNOS↓,
881- RES,    Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
- in-vitro, BC, MDA-MB-231 - in-vitro, PC, PANC1 - in-vitro, Pca, DU145
TumCCA↑, cycD1/CCND1↓, Bcl-xL↓, Mcl-1↓, other↓,
924- RES,    Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells
- in-vitro, OS, U2OS - in-vitro, Lung, A549
TumCCA↑, ROS↑, γH2AX↑, ATM↑, p‑CHK1↑, cellSen↑, CXCR2↑,
884- RES,  PTS,    Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells
- in-vitro, Cerv, HeLa
TumCD↑, TumCCA↑, E6↓, Casp3↑, P53↑,
883- RES,    Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy
- Review, Var, NA
HDAC↓, TumCCA↑, Apoptosis↑, angioG↓, ROS↑,
993- RES,    Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
- in-vitro, CRC, Caco-2 - in-vivo, Nor, HCEC 1CT
TumCG↓, Glycolysis↓, PPP↓, ATP↑, PDH↑, Ca+2↝, TumCP↓, lactateProd↓, OCR↑, ECAR↓, *ECAR∅, *other?, cycE/CCNE↑, cycA1/CCNA1↑, TumCCA↑, cycD1/CCND1↑, OXPHOS↑,
1490- RES,    Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues
- Review, Var, NA
TumCCA↑, ROS↑, Ca+2↑, MMP↓, ATP↓, TOP1?, P53↑, p53 Wildtype∅, Akt↓, mTOR↓, EMT↓, *BioAv↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3054- RES,    Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
- in-vitro, Melanoma, A375
TumCG↓, P21↑, p27/CDKN1B↑, CycB/CCNB1↓, ROS↑, ER Stress↑, p‑p38↑, P53↑, p‑eIF2α↑, EP4/PTGER4↑, CHOP/DDIT3↑, Bcl-2↓, BAX↓, TumCCA↑, NRF2↓, ChemoSen↑, GSH↓,
3055- RES,    Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
BioAv↓, BioAv↓, Dose↑, eff↑, eff↑, Dose↑, BioAv↑, ROS↑, MMP↓, P21↑, p27/CDKN1B↑, TumCCA↑, ChemoSen↑, COX2/PTGS2↓, 5LO↓, VEGF↓, IL1↓, IL6↓, IL8↓, AR↓, PSA↓, MAPK↓, Hif1a↓, Glycolysis↓, miR-21↓, PTEN↑, Half-Life↝, *IGF-1↓, *IGFBP3↑, Half-Life↓,
2981- RES,    Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways
- in-vitro, Colon, HT-29 - in-vitro, Colon, SW48
TumCCA↑, p27/CDKN1B↑, cycD1/CCND1↓, TumCP↓, IGF-1R↓, Akt↓, Wnt↓, P53↑, Apoptosis↑, Sp1/3/4↓, cl‑PARP↑, β-catenin/ZEB1↓, MDM2↓,
7149- Rhe,    Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells
- in-vitro, PC, NA
TumCCA↑, Casp↑, mt-Apoptosis↑, PI3K↓, Akt↓, ChemoSen↑, ROS↑, eff↓,
3027- RosA,    Rosmarinic acid inhibits proliferation and invasion of hepatocellular carcinoma cells SMMC 7721 via PI3K/AKT/mTOR signal pathway
- in-vitro, HCC, SMMC-7721 cell
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, TumCMig↓, MMPs↓, Vim↓,
3005- RosA,    Nanoformulated rosemary extract impact on oral cancer: in vitro study
- in-vitro, Laryn, HEp2
TumCCA↑, ROS↑, Bcl-2↓, BAX↑, Casp3↑, P53↑, necrosis↑, eff↑, BioAv↑,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
3002- RosA,    Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
- Review, Var, NA
TumCG↓, TumCP↓, TumCCA↑, ChemoSen↑, NRF2↑, PERK↑, SESN2↑, HO-1↑, cl‑Casp3↑, ROS↑, UPR↑, ER Stress↑, CHOP/DDIT3↑, HER2/EBBR2↓, ER-α36↓, PSA↓, BAX↑, AR↓, P-gp/ABCB1↓, Cyt‑c↑, HSP70/HSPA5↑, eff↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, cl‑PARP↑, Synergy↑,
3033- RosA,    Rosemary (Rosmarinus officinalis) Extract Modulates CHOP/GADD153 to Promote Androgen Receptor Degradation and Decreases Xenograft Tumor Growth
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, LNCaP - vitro+vivo, NA, NA
ER Stress↑, selectivity↑, AR↓, TumCG↓, TumCCA↑, CHOP/DDIT3↑, PERK↓, GRP78/BiP↑, PSA↓,
3035- RosA,    Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling
- in-vitro, PC, NA - in-vivo, NA, NA
Gli1↓, TumCCA↑, TumCMig↓, TumCI↓, CDK2↓, cycE/CCNE↓, P21↑, p27/CDKN1B↑,
1747- RosA,    Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review
- Review, BC, MDA-MB-231 - Review, BC, MDA-MB-468
TumCCA↑, TNF-α↑, GADD45A↑, BNIP3↑, survivin↓, Bcl-2↓, BAX↑, HH↓, Synergy↑, ChemoSen↑, RadioS↑, TumCP↓, TumCMig↓, Apoptosis↑, RenoP↑, CardioT↓,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
7377- RS,    Reserpine Induces Apoptosis and Cell Cycle Arrest in Hormone Independent Prostate Cancer Cells through Mitochondrial Membrane Potential Failure
- in-vitro, Pca, PC3
TumCCA↑, MMP↑, ROS↓,
7375- RS,    Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancer
- in-vitro, BC, MDA-MB-231
eff↝, TumCCA↑, TumCMig↓, ROS↑, BAX↑, Mst1↑, Bcl-2↓, YAP/TEAD↓, LATS1↓,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
106- RT,    Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells
- in-vivo, BC, MCF7
P-gp/ABCB1↓, TumCCA↑, Apoptosis↑, ChemoSen↑,
4899- Sal,    Anticancer activity of salinomycin quaternary phosphonium salts
- in-vitro, Var, NA
eff↑, selectivity↑, CSCs↓, TumCCA↑, MMP↓, ROS↑, mitResp↑,
4902- Sal,  OXA,    Salinomycin and oxaliplatin synergistically enhances cytotoxic effect on human colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, NA
RadioS↑, ChemoSen↑, TumCP↓, Apoptosis↑, ROS↑, MMP↓, MAPK↑, eff↓, TumCG↓, TumCCA↑,
4903- Sal,    Salinomycin: A new paradigm in cancer therapy
- Review, Var, NA
TumCG↓, ATP↓, CSCs↓, ROS↑, Casp↑, MMP↓, selectivity↑, OXPHOS↓, STAT3↓, P53↑, γH2AX↑, cycD1/CCND1↓, TumCCA↑, DNAdam↑, ChemoSen↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp/ABCB1↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
- in-vitro, Var, NA
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, Synergy↑,
6442- SAO,    Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review
- Review, RCC, NA
AntiTum↑, Apoptosis↑, TumCCA↑, *Inflam↓, selectivity↑, tumCV↓, Casp8↓, Casp9↓, Casp6↓, Casp3↓, cl‑PARP↑, angioG↓, VEGFR2/KDR/Flk1↓, Akt↑, mTOR↓, TumCG↓, *GSTs↑, *antiOx↑, *ROS↓,
6445- SAO,    Antineoplastic Effects of α-Santalol on Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancer Cells through Cell Cycle Arrest at G2/M Phase and Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10 - in-vitro, BC, MCF-10AT
tumCV↓, TumCP↓, selectivity↑, TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, Casp3↑, Casp6↑, Casp7↑,
6448- SAO,    A novel chemopreventive mechanism for a traditional medicine: East Indian sandalwood oil induces autophagy and cell death in proliferating keratinocytes
- in-vitro, Nor, HaCaT
*TumCCA↑, *AP-1↓, chemoPv↑,
6449- SAO,    Skin cancer chemoprevention by α-santalol
- Review, Melanoma, A431
*chemoPv↑, Apoptosis↑, Casp↑, MMP↓, Cyt‑c↑, TumCCA↑, TumCG↓,
5038- SAS,  Rad,    Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma
- in-vivo, Melanoma, B16-F10
xCT/SLC7A11↓, ROS↑, RadioS↓, GSH↓, selectivity↑, DNArepair↓, TumCCA↑, H2O2↑, Dose↝,
4486- Se,  Chit,    Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
- in-vitro, Liver, HepG2
Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,
4483- Se,  Chit,    Anti-cancer potential of chitosan-starch selenium Nanocomposite: Targeting osteoblastoma and insights of molecular docking
- in-vitro, OS, NA
AntiCan↑, TumCP↓, Apoptosis↑, ROS↑, eff↑, other↝, eff↑, TumCCA↑,
4603- SeNPs,    Therapeutic applications of selenium nanoparticles
- Review, Var, NA
AntiCan↑, Imm↑, *AntiDiabetic↑, *antiOx↑, *Inflam↓, ROS↑, ER Stress↑, DNAdam↑, *toxicity↓, *eff↑, *BioAv↑, selectivity↑, TumCCA↑, Risk↓, *lipid-P↓, *TNF-α↓, *CRP↓, TumMeta↓, angioG↓, selectivity↑, Synergy↑, *Synergy↑,
4448- SeNPs,    Selenium Nanoparticles: A Comprehensive Examination of Synthesis Techniques and Their Diverse Applications in Medical Research and Toxicology Studies
- Review, Nor, NA
*toxicity↓, *toxicity↓, selectivity↑, *antiOx↑, *cognitive↑, *other↝, TumCCA↑,

Showing Research Papers: 1001 to 1050 of 1163
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1163

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 6,   antiOx↑, 25,   antiOx⇅, 2,   ARE↑, 1,   ARE/EpRE↑, 1,   Catalase↓, 14,   Catalase↑, 7,   Copper↑, 1,   DJ-1↓, 1,   ENOX2↓, 1,   Fenton↑, 4,   GCLM↓, 1,   GPx↓, 3,   GPx↑, 5,   GPx1↓, 2,   GPx4↓, 20,   GPx4∅, 1,   GSH?, 1,   GSH↓, 65,   GSH↑, 10,   GSH⇅, 1,   GSH/GSSG↓, 3,   GSR↓, 2,   GSR↑, 1,   GSSG↓, 1,   GSTs↓, 4,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 10,   HO-1↓, 6,   HO-1↑, 25,   HO-2↓, 1,   Iron↓, 3,   Iron↑, 8,   Iron↝, 1,   i-Iron↑, 2,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 2,   lipid-P↓, 5,   lipid-P↑, 33,   MDA↓, 6,   MDA↑, 13,   i-MDA↑, 1,   NADH↓, 2,   mt-NADH↓, 1,   mt-NADH↑, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 4,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 29,   NRF2↑, 34,   NRF2⇅, 1,   NRF2↝, 1,   Prx↓, 2,   Prx4↑, 1,   Prx6↑, 1,   PrxII↓, 2,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 3,   ROS↓, 51,   ROS↑, 534,   ROS⇅, 11,   ROS↝, 4,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 5,   mt-ROS↑, 9,   SOD?, 1,   SOD↓, 16,   SOD↑, 11,   SOD1↓, 2,   SOD1↑, 1,   SOD2↓, 5,   mt-SOD2↑, 1,   TBARS↓, 1,   TBARS↑, 1,   Thiols↓, 2,   TKT↓, 1,   Trx↓, 7,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 2,   ox-Trx1↑, 1,   TrxR↓, 12,   TrxR↑, 1,   TrxR1↓, 8,   TrxR1↑, 1,   xCT/SLC7A11↓, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   FTH1↓, 2,   IronCh↑, 3,   Mets↑, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   BCR-ABL↓, 1,   CDC16↓, 1,   CDC2↓, 12,   p‑CDC2↓, 1,   CDC25↓, 30,   CDC25↑, 2,   CDC25↝, 1,   p‑CDC25↑, 1,   compI↓, 4,   compII↓, 2,   compIII↓, 1,   compV↓, 1,   EGF↓, 6,   EGF↑, 1,   ETC↓, 7,   HSP60/HSPD1↓, 2,   HSP60/HSPD1↑, 1,   IDH2↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 6,   mitResp↑, 2,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↓, 3,   mtDam↑, 44,   OCR↓, 6,   OCR↑, 2,   mt-OCR↑, 1,   OXPHOS↓, 5,   OXPHOS↑, 5,   mt-OXPHOS↓, 1,   mt-OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 4,   PINK1↑, 1,   SIRT3↓, 3,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 6,   5LO↓, 5,   ACC↓, 1,   ACC↑, 3,   p‑ACC↑, 1,   ACLY↓, 2,   ACSL4↑, 2,   ALAT↓, 10,   ALDOA↓, 2,   AMP↓, 1,   AMP↑, 1,   AMPK?, 1,   AMPK↓, 3,   AMPK↑, 37,   AMPK↝, 1,   p‑AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 40,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 4,   CholSyn↓, 1,   ECAR↓, 4,   ECAR↑, 1,   ECAR↝, 1,   ENO1↓, 3,   FABP4↓, 1,   FASN↓, 9,   G6PD↓, 2,   GAPDH↓, 2,   GLO-I↓, 2,   GLS↓, 2,   glucoNG↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 18,   GlucoseCon∅, 1,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 1,   Glycolysis↓, 51,   GSK‐3β↓, 15,   GSK‐3β↑, 9,   p‑GSK‐3β↓, 9,   H2S↑, 1,   Histones↑, 2,   HK1↓, 2,   HK2↓, 26,   HMG-CoA↓, 1,   IDH1↑, 1,   IDO1↓, 1,   lactateProd↓, 23,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 17,   LDL↓, 4,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 2,   NADPH↓, 4,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 4,   PFK1↓, 1,   PGK1↓, 1,   PKM1↑, 1,   PKM2↓, 21,   PKM2↑, 1,   PKM2∅, 1,   PLA2↓, 1,   PPP↓, 2,   Pyrim↓, 1,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 2,   SCD1↓, 2,   SIRT1↓, 10,   SIRT1↑, 5,   SLC25A1↓, 1,   SREBF2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA↓, 2,   TCA↑, 1,   TS↓, 2,   Warburg↓, 10,  

Cell Death(tgid=5) ⓘ

AIF↑, 22,   APAF1↑, 11,   Apoptosis?, 2,   Apoptosis↓, 12,   Apoptosis↑, 657,   mt-Apoptosis↑, 11,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 3,   p‑ASK1↑, 1,   BAD↓, 3,   BAD↑, 23,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 14,   BAX↓, 6,   BAX↑, 251,   BAX↝, 3,   Bax:Bcl2↑, 67,   Bcl-2↓, 276,   Bcl-2↑, 8,   Bcl-2↝, 2,   Bcl-2∅, 1,   Bcl-xL↓, 70,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 12,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 10,   BNIP3↑, 4,   BNIP3↝, 1,   BOK↑, 1,   BTG3↑, 1,   Casp↓, 4,   Casp↑, 73,   Casp↝, 2,   Casp∅, 1,   cl‑Casp↑, 3,   Casp1↓, 2,   Casp1↑, 3,   proCasp1↓, 1,   Casp10↓, 1,   Casp10↑, 3,   Casp12?, 1,   Casp12↑, 5,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp2↑, 2,   Casp3↓, 6,   Casp3↑, 295,   Casp3↝, 2,   cl‑Casp3↑, 65,   cl‑Casp3⇅, 1,   proCasp3↓, 3,   proCasp3↑, 3,   pro‑Casp3↑, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 3,   Casp7↑, 32,   cl‑Casp7↑, 7,   Casp8↓, 3,   Casp8↑, 66,   Casp8∅, 1,   cl‑Casp8↑, 11,   proCasp8↑, 3,   Casp9↓, 2,   Casp9↑, 171,   p‑Casp9↑, 1,   cl‑Casp9↑, 21,   proCasp9↓, 2,   proCasp9↑, 3,   cFLIP↓, 8,   Cyt‑c↓, 4,   Cyt‑c↑, 162,   Cyt‑c↝, 5,   mt-Cyt‑c↓, 1,   Diablo↑, 10,   DR5↓, 1,   DR5↑, 36,   Endon↑, 2,   FADD↑, 9,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 34,   FasL↑, 18,   FasL⇅, 1,   Ferroptosis↑, 31,   GSDME↑, 1,   cl‑GSDME↑, 2,   HEY1↓, 1,   IAP1↓, 14,   IAP1↑, 1,   IAP2/BIRC3↓, 3,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 18,   iNOS↑, 1,   Mcl-1↓, 34,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 16,   MLKL↑, 2,   MOMP↓, 1,   MOMP↑, 8,   NAIP↓, 1,   Necroptosis↑, 6,   necrosis↑, 6,   NOXA↑, 6,   oncosis↑, 1,   P2X7↓, 1,   p38↓, 7,   p38↑, 31,   p‑p38↓, 5,   p‑p38↑, 7,   PUMA↓, 1,   PUMA↑, 10,   Pyro↑, 7,   RIP1↓, 2,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 80,   TNFR 1↑, 2,   TRAIL↑, 6,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 2,   TumCD↑, 61,   TUNEL↑, 2,   XIAP?, 1,   XIAP↓, 38,   XIAP↑, 1,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 245,   Akt↑, 9,   Akt↝, 1,   p‑Akt↓, 69,   p‑Akt↑, 2,   AKT1↓, 6,   Akt2↓, 3,   AMPKα↑, 4,   BRAF↓, 1,   CaMKII ↓, 1,   CDC7↓, 1,   CIP2A↓, 1,   CK2↓, 7,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 56,   EGFR↑, 1,   p‑EGFR↓, 6,   ERK↓, 67,   ERK↑, 18,   ERK↝, 2,   p‑ERK↓, 20,   p‑ERK↑, 7,   p‑ERK⇅, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 23,   IGF-1R↓, 2,   IGFR↓, 3,   IKKα↓, 10,   p‑IKKα↓, 2,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 2,   JAK↓, 7,   JAK1?, 1,   JAK1↓, 6,   JAK1↑, 1,   p‑JAK1↓, 2,   JAK2↓, 20,   p‑JAK2↓, 5,   p‑JAK3↓, 1,   JNK↓, 7,   JNK↑, 42,   JNK↝, 2,   p‑JNK↓, 4,   p‑JNK↑, 5,   LATS1↓, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 57,   MAPK↑, 30,   MAPK↝, 4,   p‑MAPK↓, 2,   p‑MAPK↑, 2,   MARK4↓, 2,   MEK↓, 7,   p‑MEK↓, 2,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 116,   mTOR↑, 3,   mTOR↝, 2,   p‑mTOR↓, 15,   mTORC2↓, 5,   p42↓, 1,   p70S6↓, 6,   p70S6↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 7,   p‑P70S6K↓, 2,   p85S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PI3K↓, 176,   PI3K↑, 6,   PI3K↝, 2,   p‑PI3K↓, 8,   p‑PI3K↑, 1,   PI3K/Akt↓, 7,   PI3K/Akt↑, 1,   PI3k/Akt/mTOR↓, 6,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 14,   PP2A↑, 1,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 1,   PTEN↑, 33,   p‑PTEN↓, 1,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 17,   RET↓, 1,   RPS6KA1↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 16,   Src↓, 1,   Src↑, 1,   STAT↓, 5,   STAT3↓, 120,   STAT3↑, 6,   STAT3↝, 1,   p‑STAT3↓, 28,   p‑STAT3↑, 2,   STAT5↓, 4,   STAT6↓, 4,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 2,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 4,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF2↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 19,   ATF4↝, 1,   p‑ATF4↝, 1,   ATFs↑, 1,   BRD4↓, 1,   CBP↓, 3,   CBP↑, 1,   ChrMod↑, 3,   ChrMod↝, 1,   cJun↓, 8,   cJun↑, 4,   p‑cJun↑, 1,   cMyc↓, 65,   cMyc↑, 2,   DNMT1↓, 15,   DNMT1↑, 1,   DNMT3A↓, 3,   DNMT3B↓, 2,   DNMTs↓, 11,   EZH2↓, 2,   FOXM1↓, 8,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 3,   FOXO3↓, 8,   FOXO3↑, 8,   FOXO3↝, 1,   FOXO4↓, 2,   GATA3↓, 1,   H3↓, 2,   H3↑, 4,   p‑H3↓, 2,   p‑H3↑, 1,   ac‑H3↑, 10,   H3K27ac↓, 1,   H3K4↓, 1,   H4↑, 2,   ac‑H4↑, 7,   ac‑H4∅, 1,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 48,   HDAC1↓, 9,   HDAC10↓, 1,   HDAC2↓, 7,   HDAC3↓, 7,   HDAC4↓, 2,   HDAC8↓, 4,   HMTs↓, 2,   JHDM1D-AS1↓, 1,   KLF4↓, 1,   miR-106b↓, 1,   miR-107↑, 2,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 4,   miR-195↑, 1,   miR-199↓, 1,   miR-199↑, 1,   miR-19b↓, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-206↑, 1,   miR-21↓, 8,   miR-21↑, 2,   miR-210↑, 1,   miR-215-5p↑, 1,   miR-218↑, 1,   miR-22↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-27a-3p↓, 2,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-326-5p↑, 1,   miR-339-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 11,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-422a↑, 2,   MTA2↓, 1,   Myc↓, 6,   Myc↑, 1,   MYCN↓, 1,   n-MYC↓, 2,   NDRG1↑, 1,   NNMT↓, 1,   OCT4↓, 16,   other?, 2,   other↓, 9,   other↑, 7,   other↝, 25,   other∅, 2,   OV6↓, 1,   PAX2↓, 1,   PCAF↓, 1,   PhotoS↑, 4,   PRC2↓, 1,   PRMT6↓, 1,   SBF2-AS1↓, 1,   Set9↑, 1,   sonoS↑, 1,   SOX2↓, 15,   SOX4↓, 4,   SOX4↑, 1,   SUV39H↓, 3,   TBX3↑, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV?, 2,   tumCV↓, 152,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP/DDIT3↑, 41,   p‑CHOP/DDIT3↝, 1,   cl‑CHOP/DDIT3↑, 1,   EDEM↑, 1,   eIF2α↓, 3,   eIF2α↑, 11,   p‑eIF2α↑, 6,   p‑eIF2α↝, 1,   ER Stress↓, 4,   ER Stress↑, 85,   ER Stress↝, 1,   ERStress↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 19,   GRP94↑, 1,   HSF1↓, 2,   HSP27↓, 8,   HSP27↑, 3,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 5,   HSP70/HSPA5↝, 1,   HSP90↓, 24,   HSP90↑, 2,   HSPs↓, 3,   IRE1↑, 4,   PDI↑, 1,   PERK↓, 1,   PERK↑, 12,   p‑PERK↑, 1,   p‑PERK↝, 1,   UPR↑, 16,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 2,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↓, 1,   ATG5↑, 11,   ATG7↑, 2,   AVOs↑, 1,   Beclin-1/ATG6↓, 6,   Beclin-1/ATG6↑, 20,   CTSB↓, 2,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 4,   LC3A↑, 2,   LC3B↓, 1,   LC3B↑, 2,   LC3B-II↓, 1,   LC3B-II↑, 4,   LC3II↓, 2,   LC3II↑, 13,   LC3s↑, 2,   LC3s↝, 1,   MitoP↓, 1,   p62↓, 9,   p62↑, 7,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 4,   TumAuto↓, 4,   TumAuto↑, 84,   TumAuto⇅, 1,   TumAuto↝, 2,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 11,   p‑ATM↑, 2,   ATR↑, 4,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↑, 2,   DNA-PK↑, 1,   DNAdam↓, 6,   DNAdam↑, 160,   mt-DNAdam↑, 1,   DNArepair↓, 8,   ERCC3↑, 1,   m-FAM72A↓, 1,   G9a↓, 2,   HR↓, 1,   hTERT/TERT↓, 17,   MDMX↓, 1,   MGMT↓, 2,   MSH2↑, 1,   NHEJ↓, 1,   p16↑, 7,   P53?, 1,   P53↓, 9,   P53↑, 213,   P53↝, 3,   p‑P53↓, 2,   p‑P53↑, 5,   ac‑P53↑, 1,   p53 Wildtype↓, 1,   p53 Wildtype∅, 1,   p73↑, 1,   PARP↓, 9,   PARP↑, 36,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 143,   PARP1↓, 1,   PARP1↑, 5,   cl‑PARP1↑, 3,   PCNA↓, 48,   PCNA↑, 1,   PCNA↝, 1,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 3,   SIRT6↑, 1,   Telomerase↓, 15,   TOP1?, 1,   TOP1↓, 8,   TOP2↓, 7,   TP53↑, 4,   TRF2↓, 2,   UHRF1↓, 2,   XRCC1↓, 1,   γH2AX↑, 26,   γH2AX↝, 1,   p‑γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 2,   CDK1↓, 45,   CDK1↑, 7,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK1/2/5/9∅, 1,   CDK2↓, 90,   CDK2↑, 6,   p‑CDK2↓, 1,   CDK4↓, 114,   CDK4↑, 5,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 35,   CDK6↑, 6,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 2,   cellSen↑, 2,   CHK1↓, 4,   CHK1↑, 4,   CHK1↝, 1,   p‑CHK1↑, 4,   Chk2↓, 2,   Chk2↑, 9,   p‑Chk2↑, 2,   ChrCon↑, 1,   Cyc↓, 8,   cycA1/CCNA1↓, 33,   cycA1/CCNA1↑, 5,   CycB/CCNB1↓, 74,   CycB/CCNB1↑, 10,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 220,   cycD1/CCND1↑, 6,   cycD1/CCND1↝, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 4,   CycD3↑, 1,   cycE/CCNE↓, 63,   cycE/CCNE↑, 5,   cycE1↓, 4,   cycF↓, 1,   cycF↑, 1,   E2F4↑, 1,   E2Fs↓, 10,   FBXO5/EMI1↓, 1,   GADD45A↑, 5,   Ki-67↓, 49,   mitA↑, 4,   p19↑, 3,   P21?, 2,   P21↓, 10,   P21↑, 193,   P21↝, 1,   p27/CDKN1B↓, 7,   p27/CDKN1B↑, 75,   cl‑p27/CDKN1B↓, 1,   PLK1↓, 1,   pRB↓, 5,   pRB↑, 1,   p‑pRB↓, 7,   RB1↑, 6,   p‑RB1↓, 10,   cl‑RB1↓, 1,   Securin↓, 2,   TumCCA?, 8,   TumCCA↓, 29,   TumCCA↑, 1128,   TumCCA⇅, 1,   TumCCA∅, 1,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 3,   p‑4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 4,   AXIN1↓, 1,   Axin2↓, 1,   Axin2↑, 1,   BMI1↓, 1,   BMP7/OP1↓, 3,   BMPs↑, 1,   CD133↓, 17,   CD24↓, 3,   CEBPA↑, 1,   cFos↓, 6,   cFos↑, 1,   cMYB↓, 3,   CSCs?, 1,   CSCs↓, 68,   CSCs↑, 1,   Diff↓, 1,   Diff↑, 7,   EIF4E↓, 2,   EP300↑, 1,   EP4/PTGER4↑, 1,   FGF↓, 4,   Gli1↓, 12,   HH?, 1,   HH↓, 12,   HMGCR↓, 3,   IGF-1?, 1,   IGF-1↓, 12,   IGF-1↑, 1,   p‑IGF-1↓, 1,   IGFBP3↑, 4,   IGFBP7↑, 1,   p‑Jun↓, 1,   Ki-67↓, 49,   Let-7↑, 5,   LGR5↓, 1,   mTORC1↓, 6,   p‑mTORC1↓, 1,   Nanog↓, 17,   Nestin↓, 3,   NF2↑, 1,   NKD2↑, 1,   NOTCH↓, 22,   NOTCH1↓, 17,   NOTCH1↑, 3,   NOTCH2↓, 1,   NOTCH3↓, 4,   OGFr↑, 1,   p300↓, 5,   PTCH1↓, 1,   SAL↑, 1,   SCF↓, 1,   Shh↓, 15,   Smo↓, 5,   Smo∅, 1,   STAT1↓, 1,   Sufu↑, 1,   TOPflash↓, 1,   TumCG?, 4,   TumCG↓, 244,   TumCG↑, 3,   TumCP?, 2,   TumCP↓, 396,   TumCP↑, 8,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt↓, 60,   Wnt↝, 1,   Wnt/(β-catenin)↓, 15,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

67LR↓, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 17,   APC↑, 1,   ATPase↓, 2,   AXL↓, 1,   BACH1↓, 1,   CA↓, 2,   Ca+2↓, 3,   Ca+2↑, 57,   Ca+2↝, 4,   i-Ca+2↑, 4,   CAFs/TAFs↓, 1,   cal2↑, 2,   CCN2/CTGF↓, 2,   CD11b↑, 1,   Cdc42↑, 1,   Chl↑, 1,   Cofilin↓, 2,   COL1↓, 1,   COL1A1↓, 1,   COL3A1↓, 2,   E-cadherin↓, 12,   E-cadherin↑, 58,   E-cadherin↝, 1,   EMT?, 1,   EMT↓, 104,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 6,   F-actin↓, 2,   FAK↓, 19,   FAK↑, 1,   p‑FAK↓, 7,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 3,   GIT1↓, 1,   GLI2↓, 1,   ITGA5↓, 2,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 2,   KRAS↓, 2,   LAMs↓, 3,   LEF1↓, 3,   MALAT1↓, 1,   MET↓, 2,   MMP-10↓, 2,   MMP1↓, 8,   MMP13↓, 3,   MMP16↓, 2,   MMP2↓, 124,   MMP3↓, 10,   MMP7↓, 14,   MMP9↓, 152,   MMP9↑, 2,   MMP9:TIMP1↓, 1,   MMPs↓, 47,   MTA1↓, 1,   MUC1↓, 1,   MUC1-C↓, 1,   MUC4↓, 4,   N-cadherin?, 1,   N-cadherin↓, 36,   N-cadherin↑, 1,   N-cadherin↝, 1,   NCAM↓, 2,   NCAM↑, 1,   NEDD9↓, 2,   NFAT↑, 1,   p44↓, 1,   PAK1↓, 3,   pax↓, 1,   p‑pax↓, 1,   PCBP1↓, 1,   PDGF↓, 6,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 7,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 9,   Smad1↓, 1,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 4,   p‑SMAD2↓, 1,   SMAD3↓, 6,   SMAD3↑, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 21,   STAC2↓, 1,   T-cadherin↑, 1,   TET1↓, 1,   TET1↑, 5,   TGF-β↓, 24,   TGF-β↑, 1,   TGF-β↝, 1,   TGF-β1↓, 1,   THBS1↓, 1,   THBS1↑, 1,   TIMP1↓, 2,   TIMP1↑, 11,   TIMP2↓, 3,   TIMP2↑, 12,   TPM4↓, 1,   pol-TregCell↓, 1,   TRIB3↑, 1,   Trop2↓, 1,   TSC1↑, 2,   TSP-1↑, 4,   TumCA↓, 1,   TumCI↓, 152,   TumCI↑, 2,   TumCMig?, 1,   TumCMig↓, 161,   TumCMig↑, 2,   TumMeta↓, 129,   TumMeta↑, 9,   Twist↓, 18,   TXNIP↑, 1,   uPA↓, 25,   uPAR↓, 4,   Vim?, 1,   Vim↓, 42,   Vim↑, 1,   Zeb1↓, 13,   ZEB2↓, 2,   α-SMA↓, 2,   α-tubulin↓, 4,   β-catenin/ZEB1↓, 74,   β-catenin/ZEB1↑, 3,   p‑β-catenin/ZEB1↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 160,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   ECM/TCF↓, 1,   EGR1↓, 1,   Endoglin↑, 2,   eNOS↓, 3,   HIF-1↓, 10,   Hif1a↓, 90,   Hif1a↑, 2,   LOX1↓, 2,   NO↓, 6,   NO↑, 7,   VCAM-1↓, 3,   VEGF↓, 153,   VEGF↑, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 23,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 7,   BBB∅, 1,   CellMemb↑, 1,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN2↓, 2,   CTR1↑, 1,   EPR↑, 14,   GLUT1↓, 16,   GLUT2↓, 2,   GLUT4↓, 6,   IBI↑, 1,   memfluid↓, 1,   MMP?, 1,   MMP↓, 264,   MMP↑, 3,   MMP∅, 1,   MPT↑, 9,   NHE1↓, 2,   OATPs↓, 2,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2∅, 1,   TJ↑, 1,   TRPM7↓, 3,   TRPM7↑, 1,   TRPV1↑, 4,   TRPV1↝, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CB2 / CNR2↑, 3,   CCR7↓, 1,   CD155↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 20,   CD44↝, 1,   CD47↓, 1,   CD8+↑, 4,   cDC2↓, 8,   p‑cDC2↓, 2,   p‑cDC2↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 109,   COX2/PTGS2↑, 4,   COX2/PTGS2↝, 2,   CXCL12↓, 2,   CXCL9↓, 1,   CXCR2↓, 2,   CXCR2↑, 1,   CXCR4↓, 13,   DCells↑, 2,   DR4↑, 9,   DR4∅, 1,   DR6↑, 1,   FOXP3↓, 1,   FOXP3↑, 2,   Gal-3↓, 2,   HCAR2↑, 1,   HMGB1↓, 5,   ICAM-1↓, 6,   IFN-γ↓, 6,   IFN-γ↑, 2,   Igs↑, 2,   IL1↓, 7,   IL1↑, 1,   IL10↓, 3,   IL10↑, 3,   IL12↑, 1,   IL13↓, 1,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 21,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 4,   IL4↓, 1,   IL4↑, 1,   IL6↓, 53,   IL6↑, 1,   IL8↓, 12,   IL8↑, 1,   Imm↑, 28,   Imm↝, 3,   Inflam↓, 53,   Inflam↝, 1,   IRAK1↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 2,   MIP2↓, 1,   MyD88↑, 1,   NAF1↓, 1,   NF-kB?, 1,   NF-kB↓, 220,   NF-kB↑, 8,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 11,   NLRP3↓, 3,   NLRP3↑, 2,   NOD1↓, 1,   p65↓, 9,   p65↑, 1,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 2,   PD-1↓, 2,   PD-L1↓, 12,   PD-L1↑, 3,   PGE2↓, 22,   PSA↓, 20,   PSA∅, 1,   RAGE↓, 2,   SOCS-3↓, 1,   SOCS-3↑, 1,   T-Cell↑, 2,   TCF↓, 4,   Th1 response?, 1,   Th1 response↑, 1,   TLR4↓, 5,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 41,   TNF-α↑, 8,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 4,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   CAXII/CA12↑, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   BACE/β-secretase↓, 1,   PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   4-OHE1↓, 1,   6IL↑, 1,   ACE/ACE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 22,   AR↑, 1,   COMT↓, 1,   ER-α36↓, 4,   ER(estro)↓, 2,   ER(estro)↑, 1,   ERα/ESR1↓, 3,   ERβ/ESR2↑, 1,   Estro↝, 1,   EstroRS/ERS↓, 1,   FGF21↓, 1,   GR↑, 1,   PPARγ↓, 2,   PPARγ↑, 9,   PRL↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 63,   BioAv↑, 58,   BioAv↝, 12,   BioEnh↑, 6,   CBR1↓, 1,   chemoR↓, 1,   ChemoSen↓, 4,   ChemoSen↑, 271,   ChemoSen∅, 1,   CompStab?, 1,   CompStab↓, 1,   CompStab↑, 4,   CompStab↝, 1,   CYP1A1↓, 5,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1B1↓, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose?, 5,   Dose↓, 3,   Dose↑, 10,   Dose⇅, 3,   Dose↝, 98,   Dose∅, 12,   eff↓, 110,   eff↑, 148,   eff↝, 17,   eff∅, 3,   GSTA1↓, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 19,   Half-Life↑, 4,   Half-Life↝, 16,   Half-Life∅, 2,   MDR1↓, 13,   MRP1/ABCC1↓, 6,   NAT↓, 1,   P-gp/ABCB1↓, 31,   P-gp/ABCB1∅, 1,   P450↓, 5,   P450↝, 1,   RadioS?, 1,   RadioS↓, 1,   RadioS↑, 84,   RadioS↝, 1,   selectivity?, 4,   selectivity↓, 2,   selectivity↑, 190,   selectivity∅, 1,   Synergy↑, 136,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 10,   ALP↓, 4,   AR↓, 22,   AR↑, 1,   AST↓, 7,   B2M↓, 1,   BRAF↓, 1,   BRCA1↓, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 4,   E7↓, 3,   EGFR↓, 56,   EGFR↑, 1,   p‑EGFR↓, 6,   ERα/ESR1↓, 3,   EstroRS/ERS↓, 1,   EZH2↓, 2,   Ferritin↓, 2,   FOXM1↓, 8,   HER2/EBBR2↓, 23,   hTERT/TERT↓, 17,   IL6↓, 53,   IL6↑, 1,   KRAS↓, 2,   LDH↓, 9,   LDH↑, 6,   LDH↝, 3,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 6,   Myc↑, 1,   PD-L1↓, 12,   PD-L1↑, 3,   PSA↓, 20,   PSA∅, 1,   RAGE↓, 2,   TP53↑, 4,   TRIB3↑, 1,   Tumccf↓, 1,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 107,   AntiCan?, 1,   AntiDiabetic↑, 2,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 40,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 13,   CardioT↓, 2,   CardioT↑, 2,   chemoP↑, 43,   chemoPv↑, 33,   ChemoSideEff↓, 6,   cognitive↑, 1,   fatigue↓, 1,   fatigue∅, 1,   FTO↑, 1,   hepatoP↓, 2,   hepatoP↑, 15,   hepatoP∅, 1,   K17↓, 1,   kidSt↓, 1,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 14,   NP/CIPN↓, 1,   Obesity↓, 1,   Obesity↑, 1,   OS?, 1,   OS↑, 26,   OS⇅, 1,   Pain↓, 4,   PFS↑, 1,   Pin1↓, 3,   QoL↑, 10,   QoL∅, 2,   radioP↑, 11,   Remission↑, 1,   RenoP↑, 8,   Risk↓, 25,   Sleep↑, 2,   Strength↑, 2,   TGFβR1↑, 1,   toxicity?, 1,   toxicity↓, 31,   toxicity↑, 6,   toxicity↝, 9,   toxicity∅, 5,   TumVol↓, 50,   TumVol↑, 2,   TumVol∅, 1,   TumW↓, 21,   TumW∅, 1,   Weight↑, 3,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   Bacteria↑, 1,   GutMicro↑, 8,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 5,  
Total Targets: 1394

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 6,   antiOx↑, 126,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↑, 48,   Copper↓, 1,   GPx↓, 1,   GPx↑, 35,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 40,   GSR↑, 6,   GSSG↓, 1,   GSTs↑, 21,   H2O2↓, 3,   HDL↓, 1,   HDL↑, 4,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 21,   Iron↓, 2,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 44,   MDA↓, 33,   MPO↓, 5,   NADH↓, 1,   NOX4↓, 1,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 51,   Prx↑, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 117,   ROS↑, 8,   ROS↝, 1,   ROS∅, 4,   mt-ROS?, 1,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 51,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 3,   Trx1↑, 1,   uricA↓, 2,   VitC↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 1,   OCR↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 4,   ALAT↓, 12,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↑, 4,   CRM↑, 1,   DGAT1↓, 1,   ECAR↓, 1,   ECAR∅, 1,   FASN↓, 2,   glucose↓, 6,   glucose↝, 1,   GlucoseCon↑, 2,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   H2S↑, 2,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 6,   lipidLev↓, 2,   NADPH↑, 2,   SIRT1↑, 4,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   Apoptosis↓, 6,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 8,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 1,   Bcl-2↑, 4,   Casp↓, 1,   Casp1↓, 1,   Casp3?, 1,   Casp3↓, 11,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↓, 3,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 4,   Cyt‑c↑, 1,   Fas↓, 2,   Fas↑, 2,   FasL↓, 1,   Ferroptosis↓, 3,   IAP1↓, 1,   iNOS↓, 18,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 1,   p38↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 3,   Akt↝, 1,   p‑Akt↑, 1,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 2,   p‑ERK↑, 1,   IκB?, 1,   JAK↓, 1,   JNK↓, 3,   JNK↑, 3,   MAPK↓, 8,   MAPK↑, 1,   mTOR↓, 3,   mTOR↑, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 6,   PI3K↑, 2,   PKCδ↓, 1,   PTEN↑, 1,   STAT↓, 3,   STAT3↓, 2,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other?, 1,   other↓, 2,   other↑, 5,   other↝, 7,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSPs↑, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   DNArepair↑, 1,   p16↓, 1,   P53↓, 3,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 2,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↑, 1,   Ki-67↓, 1,   P21↓, 3,   P21↑, 5,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 1,   neuroG↑, 1,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 12,   AP-1↓, 3,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   COL1↑, 1,   FAK↑, 1,   LAMs↑, 1,   LRP1↑, 1,   MMP13↓, 2,   MMP9↓, 5,   MUC1↑, 1,   Smad1↑, 1,   TGF-β↓, 4,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TumCI∅, 1,   TumCMig∅, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   Hif1a↓, 2,   NO↓, 10,   NO↑, 1,   VCAM-1↓, 3,   VEGF↓, 3,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 9,   BBB↝, 2,   GastroP↑, 6,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 3,   MMP↑, 9,   MMP∅, 1,   MUC5AC↓, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   VGSC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD19↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 35,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 2,   IL1↓, 2,   IL10↓, 3,   IL10↑, 5,   IL12↓, 1,   IL17↓, 5,   IL18↓, 3,   IL1β↓, 21,   IL2↓, 1,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL5↓, 1,   IL6?, 1,   IL6↓, 29,   IL6↑, 1,   IL8↓, 8,   Imm↑, 6,   Imm⇅, 2,   Inflam?, 1,   Inflam↓, 121,   Inflam↑, 4,   IRF3↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MyD88↓, 2,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 41,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 5,   NLRP3↑, 1,   PGE2↓, 15,   PGE2↑, 1,   RAGE↓, 2,   SOCS-3↓, 1,   TLR2↓, 3,   TLR4↓, 7,   TNF-α?, 1,   TNF-α↓, 37,   TNF-α↑, 2,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 2,   AChE↓, 17,   AChE↑, 1,   BChE↓, 3,   BDNF↑, 10,   GABA↑, 3,   GABA↝, 1,   MAOA↓, 2,   NGF↑, 3,   TPH1↓, 1,   TrkB↑, 2,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   Aβ↓, 19,   BACE/β-secretase↓, 6,   tau↓, 4,   p‑tau↓, 3,   XO↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   CYP19↓, 1,   GPER↑, 1,   GR↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 2,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 50,   BioAv↑, 45,   BioAv↝, 22,   BioEnh↑, 2,   ChemoSen↑, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 10,   eff↓, 1,   eff↑, 11,   eff↝, 2,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 11,   Half-Life∅, 2,   P450↓, 3,   Synergy↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12,   ALP↓, 4,   AST↓, 15,   BloodF↑, 1,   BMD↑, 5,   BP↓, 9,   creat↓, 4,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 29,   IL6↑, 1,   IRes↑, 1,   IRes↝, 1,   LDH↓, 7,   NOS2↓, 1,   RAGE↓, 2,   TC↓, 2,   TG/TAG↓, 2,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 7,   antiAll↑, 18,   AntiArt↑, 9,   AntiCan↓, 2,   AntiCan↑, 25,   antiCG↑, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 31,   antiNeop↑, 2,   antiPs↑, 1,   AntiTum↓, 2,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↓, 1,   cardioP↑, 53,   CardioT↓, 1,   chemoP↑, 10,   chemoPv↑, 7,   cognitive↑, 17,   cough?, 1,   diuretic↑, 1,   hepatoP↑, 43,   Learn↑, 1,   memory↑, 19,   motorD↑, 3,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 82,   Obesity↓, 15,   OS↑, 1,   Pain↓, 9,   radioP↑, 4,   RenoP↓, 1,   RenoP↑, 12,   Risk↓, 1,   SoreThr?, 1,   Stress↓, 2,   Stroke↓, 11,   toxicity?, 2,   toxicity↓, 56,   toxicity↑, 6,   toxicity↝, 11,   toxicity∅, 10,   Wound Healing↑, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 17,   AntiFungal↓, 2,   AntiFungal↑, 7,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 13,   Bacteria↓, 28,   Diar↓, 3,   GutMicro↑, 15,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 443

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest
41 Curcumin
31 Quercetin
30 Silver-NanoParticles
26 Sulforaphane (mainly Broccoli)
25 Thymoquinone
23 Apigenin (mainly Parsley)
22 Berberine
21 Fisetin
21 Kaempferol
18 Radiotherapy/Radiation
18 Magnolol
17 Phenethyl isothiocyanate
16 Baicalein
16 Emodin
15 Artemisinin
15 Capsaicin
15 Piperlongumine
14 Magnetic Fields
14 Luteolin
14 Shikonin
13 Cisplatin
13 doxorubicin
13 EGCG (Epigallocatechin Gallate)
13 Chrysin
13 Garcinol
13 Lycopene
13 Resveratrol
12 Ashwagandha(Withaferin A)
12 Betulinic acid
12 Eugenol
12 Cucurbitacin
12 Honokiol
12 Licorice
11 Graviola
11 Licochalcone A
11 Linalool
10 Propolis -bee glue
9 5-fluorouracil
9 Rosmarinic acid
9 Ellagic acid
9 Formononetin
9 phytic acid, Inositol hexakisphosphate
9 Ivermectin
9 mebendazole
9 Silymarin (Milk Thistle) silibinin
9 Urolithin
8 Allicin (mainly Garlic)
8 Carvacrol
8 Crocetin
8 Diindolylmethane
8 Indole-3-carbinol
8 Ferulic acid
8 Paclitaxel/Taxol
8 Gallic acid
8 Ginkgetin
8 HydroxyTyrosol
7 Chemotherapy
7 Melatonin
7 chitosan
7 Evodiamine
7 Fucoidan
7 Juglone
7 Phenylbutyrate
7 Pterostilbene
6 Astaxanthin
6 Berbamine
6 Boswellia (frankincense)
6 Celastrol
6 chaetocin
6 Gambogic Acid
6 itraconazole
6 Matrine
6 Morin
6 Naringin
6 Selenite (Sodium)
5 Coenzyme Q10
5 Beta-Caryophyllene
5 Bufalin/Huachansu
5 Boron
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Centella asiatica / Gotu kola → asiaticoside
5 Chlorogenic acid
5 Carvone
5 Cynaropicrin
5 Dandelion Root
5 Eurycomanone
5 Fenbendazole
5 Genistein (soy isoflavone)
5 isoorientin
5 Laetrile B17 Amygdalin
5 lambertianic acid
5 methylseleninic acid
5 Methylsulfonylmethane
5 Nimbolide
5 Plumbagin
5 salinomycin
5 Ursolic acid
5 Vitamin K2
4 1,8-Cineole
4 Vitamin C (Ascorbic Acid)
4 D-limonene
4 Brucea javanica
4 Caffeic acid
4 Thymol-Thymus vulgaris
4 Selenium
4 Cinnamon
4 Hydroxycinnamic-acid
4 Deguelin
4 Hyperoside
4 Lemongrass Extract/Citral
4 Methyl Jasmonate
4 Magnetic Field Rotating
4 Moringa oleifera
4 Marjoram (Origanum majorana)
4 VitK3,menadione
4 α-Santalol/Sandalwood oil
4 Selenium NanoParticles
4 Aflavin-3,3′-digallate
3 Astragalus
3 Copper and Cu NanoParticles
3 Alpha-Lipoic-Acid
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Andrographis
3 Gemcitabine (Gemzar)
3 Anethole/trans-Anethole
3 Fennel Oil/Foeniculum vulgare
3 Isovitexin
3 Biochanin A
3 borneol
3 Bruteridin(bergamot juice)
3 Carnosic acid
3 Celecoxib
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Date Fruit Extract
3 diet Methionine-Restricted Diet
3 Piperine
3 Flaxseed/Linseed
3 SDG/lignans
3 Ginger/6-Shogaol/Gingerol
3 Hibiscus sabdariffa
3 Hyperthermia
3 Inositol
3 Isoliquiritigenin
3 Lasiodin
3 Metformin
3 Magnesium
3 Propyl gallate
3 Parthenolide
2 Gold NanoParticles
2 Photodynamic Therapy
2 Glucose
2 tamoxifen
2 DTS(dibenzyl trisulphide) from Anamu
2 Ascorbyl Palmitate
2 Atorvastatin
2 beta-glucans
2 Baicalin
2 Bacopa monnieri
2 α-Bisabolol / Chamomile oil
2 Butyrate
2 Zinc
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Chlorophyllin
2 Docetaxel
2 Dihydrocaffeic Acid
2 Cyclopamine
2 Dichloroacetate
2 Diclofenac
2 Echinacea
2 Electrical Pulses
2 Flaxseed Oil
2 carboplatin
2 Geraniol
2 isoflavones
2 isoquercitrin
2 Vitexin
2 Lactoferrin/Talactoferrin
2 Lutein
2 Methylene blue
2 Modified Citrus Pectin
2 Lemon Balm/Melissa officinalis
2 Mucuna pruriens/Velvet Bean
2 Mistletoe/Viscum album Extracts
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Oleuropein
2 Rauwolfia serpentina/Indian Snakeroot
2 Rutin
2 Terpinen-4-ol / Tea Tree Oil
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Arctigenin
1 Aloe anthraquinones
1 immunotherapy
1 epirubicin
1 brusatol
1 Bromelain
1 Carnosine
1 Selenate
1 Chocolate
1 Vitamin E
1 Polyphenols
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Dipyridamole
1 Disulfiram
1 Cannabichromene
1 Citric Acid
1 Sorafenib (brand name Nexavar)
1 flavonoids
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Ginkgolic acids
1 Ginkgo biloba
1 Germanium inorganic
1 Ginkgolide B
1 Ginseng
1 HydroxyCitric Acid
1 Rapamycin
1 High-Ozonide Oil
1 Isobavachalcone
1 iodine
1 Inulin Prebiotic
1 Recombinant Methioninase
1 Lactobacillus
1 Lapachol
1 low dose naltrexone
1 Mung Bean Sprouts
1 Dordaviprone; Modeyso
1 MCT, metronomic chemo
1 Methylglyoxal
1 Myricetin
1 Niclosamide (Niclocide)
1 Proanthocyanidins
1 Purple Corn / Purple Maize
1 Sanguinarine
1 Psoralidin
1 Rhein
1 buckwheat sprouts
1 Oxaliplatin
1 Sulfasalazine
1 Auranofin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
1 Turmerones
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:322  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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