Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Scientific Papers found: Click to Expand⟱
7906- IVT,    Isovitexin accelerates diabetic wound repair via coordinated angiogenesis and collagen remodeling: Mechanistic insights from cellular and streptozotocin-induced SD rat models
- in-vivo, Nor, NA
*Inflam↓, *Wound Healing↑, *angioG↑, *ROS↓, *Apoptosis↓, *PI3K↑, *Akt↑, *eNOS↑,
7892- IVT,    Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway
- in-vitro, Nor, HCEC 1CT - in-vivo, Colon, NA
TumCP↓, selectivity↑, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑, TumVol↓, TumW↓,
7893- IVT,    Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress
- vitro+vivo, Liver, NA
TumCG↓, Apoptosis↑, BAX↑, cl‑Casp3↑, cl‑PARP↑, Cyt‑c↑, TumAuto↑, LC3II↑, ATG3↑, ATG5↑, Beclin-1/ATG6↑, ER Stress↑, IRE1↑, XBP-1↑, CHOP/DDIT3↑, GRP78/BiP↑, *chemoPv↑,
7888- IVT,    Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways
- vitro+vivo, Nor, NA
*Inflam↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Apoptosis↓, *p‑MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *ICAM-1↓, *VCAM-1↓, *MPO↓, *MDA↓, *GSH↑, *SOD↑,
8007- JG,    Juglone reduces growth and migration of U251 glioblastoma cells and disrupts angiogenesis
- in-vitro, GBM, U251
Pin1↓, AntiCan↑, TumCP↓, Apoptosis↑, Casp3↑, TumCMig↓, angioG↓, VEGF↓, CD31/PECAM-1↓, TGF-β1↓,
7965- JG,    Mechanistic investigation of Juglone (5-hydroxy-1,4-naphthoquinone) as an anti-cancer agent in human colorectal cancer HCT116 and HT-29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
Apoptosis↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Bcl-2↓, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, ERK↓, AKT1↓, p38↑, JNK↑, TumCMig↓, TumCI↓, TumMeta↓,
7961- JG,    Juglone Inhibits Tumor Metastasis by Regulating Stemness Characteristics and the Epithelial-to-Mesenchymal Transition in Cancer Cells both in Vitro and in Vivo
- vitro+vivo, BC, MCF7 - in-vitro, BC, 4T1 - vitro+vivo, CRC, HCT116
EMT↓, CSCs↓, TumMeta↓, Pin1↓, TumCCA↑, angioG↓, Apoptosis↑, BAX↑, Bcl-2↓,
5118- JG,    Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells
- in-vitro, HCC, HepG2
m-ROS↑, DNAdam↑, Apoptosis↑, TumAuto↑, p38↑, MAPK↑, JNK↑, MMP↓, LC3II↑, Beclin-1/ATG6↑,
5099- JG,    Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK
- vitro+vivo, GBM, LN229 - vitro+vivo, GBM, T98G
Ferroptosis↑, p‑MAPK↑, NRF2↓, GPx4↓, TumPF↓, Apoptosis↑, ROS↑, GSH↓, lipid-P↑, Ki-67↓, TumCG↓,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, eff↑, BAX↑, Fas↑, Pin1↓,
5117- JG,    https://pubmed.ncbi.nlm.nih.gov/31283929/
- vitro+vivo, Liver, NA
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, AMPK↑, mTOR↑, P53↑, H2O2↑, ROS↑,
1918- JG,    ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro
- in-vitro, Liver, HepG2 - in-vivo, NA, NA
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, AMPK↑, mTOR↑, P53↑, H2O2↑, ROS↑, toxicity↝, p62↓, DR5↑, Casp8↑, PARP↑, cl‑Casp3↑,
1927- JG,    Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway
- in-vitro, GC, SGC-7901
Apoptosis↑, ROS↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, Casp3?, Bax:Bcl2↑,
1924- JG,    Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Cyt‑c↑, ROS↑, MDA↑, GPx4↓, SOD↓, PI3K↓, Akt↓, eff↓,
1922- JG,    Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma
- in-vitro, GBM, U87MG
tumCV↓, TumCP↓, ROS↑, p‑p38↑, eff↓, Apoptosis↑, OS↑,
1919- JG,    The Anti-Glioma Effect of Juglone Derivatives through ROS Generation
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
ROS↑, Apoptosis↑, eff↓, eff↓,
8085- KAE,    Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, PI3K↓, Akt↓, STAT3↓, AP-1↓, NRF2↓, BioAv↑, Inflam↓, NF-kB↓, TNF-α↓, VEGF↓, BAX↑, Casp↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, NRF2↓, ROS↑, DR5↑, ERK↑, CHOP/DDIT3↑, DR4↑, JNK↑, Ki-67↓, ChemoSen↑,
8087- KAE,    Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways
- Review, Var, NA
TumCCA↓, ROS↝, Apoptosis↑, TumCP↑, TumMeta↓, angioG↓, PI3K↓, EMT↓, Snail↓, E-cadherin↓, N-cadherin↓, MMP2↓, Casp9↑, Casp7↑, PARP↑, Apoptosis↑, *ROS↓, Hif1a↓, p‑Akt↓, P53↑, cMyc↓, Glycolysis↓, PKM2↓, miR-339-5p↝, BioAv↓,
8092- KAE,    Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells
- in-vitro, Colon, HCT116 - in-vitro, Colon, DLD1
TumCP↓, TumCCA↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, ATP↓, miR-339-5p↑, Glycolysis↓, PKM2↓, PKM1↑,
8093- KAE,    Kaempferol inhibits Nrf2 signalling pathway via downregulation of Nrf2 mRNA and induces apoptosis in NSCLC cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
GSTA1↓, NQO1↓, HO-1↓, NRF2↓, ROS↑, Apoptosis↑,
8096- KAE,  5-FU,    Synergistic effect of kaempferol and 5‑fluorouracil on the growth of colorectal cancer cells by regulating the PI3K/Akt signaling pathway
- in-vitro, CRC, HCT8 - in-vitro, CRC, HCT8
ChemoSen↑, TumCP↓, Apoptosis↓, BAX↑, Bcl-2↓, TS↓, PI3K↓, Akt↓,
8097- KAE,    The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells
- in-vitro, CRC, LS174T
ChemoSen↑, tumCV↓, Apoptosis↑, TumCCA↑, ROS↓, Casp3↑, Casp9↑, cl‑PARP↑, p‑STAT3↓, Akt↓, FOXO3↓, NF-kB↓, VEGF↓, TS↓, TK1↓,
8100- KAE,    Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways
- in-vitro, Cerv, HeLa
*antiOx↑, *AntiTum↑, Apoptosis↑, TumCD↑, tumCV↓, PI3K↓, Akt↓, hTERT/TERT↓,
8102- KAE,    Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study
- vitro+vivo, GC, MKN-28 - vitro+vivo, GC, SGC-7901 - in-vitro, GC, GES-1
TumCP↓, TumCCA↑, Apoptosis↑, selectivity↑, TumVol↓, CycB/CCNB1↓, CDK1↓, CDC25↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, p‑Akt↓, p‑ERK↓, COX2/PTGS2↓,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓,
8106- KAE,    Anticancer effects of kaempferol in A375 human malignant melanoma cells are mediated via induction of apoptosis, cell cycle arrest, inhibition of cell migration and downregulation of m-TOR/PI3K/AKT pathway
- in-vitro, Melanoma, A375
Apoptosis↑, TumCCA↑, TumCMig↓, mTOR↓, PI3K↓, Akt↓,
8107- KAE,    Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B
- in-vitro, Ovarian, A2780S
Apoptosis↑, tumCV↓, TumCP↓, TumAuto↑, GRP78/BiP↑, PERK↑, ATF6↑, IRE1↑, LC3II↑, Beclin-1/ATG6↑, Ca+2↑, ChemoSen↑, ER Stress↑,
8071- KAE,    Cellular reprogramming and signaling control by kaempferol in colorectal cancer
- Review, CRC, NA
*toxicity↓, Risk↓, MMPs↓, VEGF↓, VEGFR1↓, Wnt↓, β-catenin/ZEB1↑, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, *BioAv↓, TumCCA↑, Apoptosis↑, Hif1a↓, ROS↑, TumCMig↓, TumMeta↓, PKM2↓, Glycolysis↓, DNAdam↑, HO-1↑, Ferroptosis↑, eff↑, Dose↝, BioAv↑,
8059- KAE,    Kaempferol Inhibits Cervical Cancer Cells by Inducing Apoptosis and Autophagy via Inactivation of the PI3K/AKT/mTOR Signaling Pathway
- in-vitro, Cerv, KB
*antiOx↑, *Inflam↓, tumCV↓, TumCMig↓, TumAuto↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Apoptosis↑, PI3K↓, Akt↓, mTOR↓,
8061- KAE,    Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, OVCAR-3
TumCP↓, Apoptosis↑, Casp3↑, Casp7↑, Risk↓, VEGF↓, TumCP↓, Dose↝, P53↑,
8064- KAE,    Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1 - in-vitro, PC, SNU-213
AntiCan↑, tumCV↓, Apoptosis↑, TumCMig↓, *toxicity↓, Dose?,
8067- KAE,  Cisplatin,    Kaempferol Induces Cell Death and Sensitizes Human Head and Neck Squamous Cell Carcinoma Cell Lines to Cisplatin
- in-vitro, HNSCC, NA
AntiCan↑, OCR↓, i-ATP↓, TumCMig↓, TumCP↓, Apoptosis↑, ChemoSen↑,
8070- KAE,    Kaempferol: Paving the path for advanced treatments in aging-related diseases
- Review, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *NF-kB↓, *Akt↝, *β-catenin/ZEB1↝, *Aβ↓, *BDNF↑, Apoptosis↑, TumCCA↑, EMT↓, PI3K↓,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, eff↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, P53↑, Bcl-2↓, PARP↑, ERK↓, IQGAP3↓, γH2AX↑, cl‑Casp3↑, cl‑Casp9↑, Rho↓, Rac1↓, MMP2↓, MMP9↓, CTSB↓, CTSD↓, O-Glc↓, SERPINH1/HSP47↓, EMT↓, angioG↓, EGF↓, VEGFR2/KDR/Flk1↓, RadioS↑,
8077- KAE,    Kaempferol exerts anti-colorectal cancer effects through its multi-target mediated glucose metabolism remodeling
- in-vitro, CRC, NA
AntiTum↑, Glycolysis↓, PPP↓, OXPHOS↑, ROS↑, MMP↓, Apoptosis↑, TKT↓, ALDOA↓, TumCP↓,
8078- KAE,    Kaempferol induces mitophagy and disrupts iron metabolism via SFXN2 leading to apoptosis in multiple myeloma cells
- in-vitro, Mye, NA
TumCP↓, Apoptosis↑, mtDam↑, mt-TumAuto↑, i-Iron↑, SFXN2↓,
8079- KAE,    Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Kaempferol in Colorectal Cancer Cells
- in-vitro, CRC, DLD1 - in-vitro, Lung, A549 - in-vitro, Liver, HUH7 - in-vitro, Cerv, HeLa
*antiOx↑, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, Dose↝, TumCP↓, ER Stress↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Casp12↝, NF-kB↓, P53↑,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
8053- KAE,    Kaempferol as a therapeutic agent in Alzheimer's disease: Evidence from preclinical studies
- Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *Apoptosis↓, *AChE↓,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
8147- Lae,    Mechanisms underlying the therapeutic effects of Amygdalin in treating Cervical Cancer based on multi-omics analysis
- in-vitro, Cerv, Ca9-22 - in-vitro, Cerv, HeLa
TumCP↓, Apoptosis↑, TumCCA↑, HK2↓, CAIX/CA9↓,
8148- lamb,    Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells
- in-vitro, Pca, LNCaP
*antiAll↑, *Bacteria↓, AR↓, PSA↓, TumCCA↑, CDK4↓, CDK6↓, cycD1/CCND1↓, P53↑, P21↑, p27/CDKN1B↓, Apoptosis↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Dose↝,
8161- LapC,    Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells
- in-vitro, ESCC, KYSE-30 - in-vitro, ESCC, KYSE450 - in-vitro, ESCC, KYSE-510
RSK2/RPS6KA3/p90RSK2↓, TumCG↓, Apoptosis↑, Casp3↑, Casp7↑, PARP↑, Cyt‑c↑, BAX↑, p‑CREB↓, ATF1↓, H3↓, CycB/CCNB1↓, cycD1/CCND1↓, p‑CDK2↓,
8162- LapC,    Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
- in-vitro, Melanoma, MEL526 - in-vitro, Melanoma, MEL697 - in-vitro, Melanoma, MEL103
Glycolysis↓, OCR↑, PKM2↓, ATP↓, TumCP↓, Apoptosis↑, OXPHOS↑, Dose↝,
8164- LapC,    Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II
- vitro+vivo, GBM, NA
TumCP↓, Apoptosis↑, DNAdam↑, TOP1↓, TOP2↓,
8175- Las,    Lasiodin Inhibits Proliferation of Human Nasopharyngeal Carcinoma Cells by Simultaneous Modulation of the Apaf-1/Caspase, AKT/MAPK and COX-2/NF-κB Signaling Pathways
- in-vitro, NPC, NA
tumCV↓, TumCMig↓, APAF1↑, Cyt‑c↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, p‑Akt↓, p‑ERK↓, p‑p38↓, p‑JNK↓, COX2/PTGS2↓, NF-kB↓, chemoPv↑,
8176- Las,    In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model
- vitro+vivo, BC, NA
TumCCA↑, Apoptosis↑, DNAdam↑, TumMeta↓, PI3K↓, Akt↓, mTOR↓, STAT3↓, TumVol↓, toxicity↓,
8177- Las,    Lasiokaurin Regulates PLK1 to Induce Breast Cancer Cell G2/M Phase Block and Apoptosis
- vitro+vivo, BC, MDA-MB-231
Dose↝, tumCV↓, Apoptosis↑, TumCCA↑, PLK1↓, CDC25↓, Akt↓,
8179- Las,    Lasiokaurin suppresses hepatocellular carcinoma proliferation and induces apoptosis via the JAK2/STAT3 pathway
- in-vitro, HCC, NA
Apoptosis↑, TumCCA↑, TumCG↓, JAK2↓, STAT3↓,

Showing Research Papers: 1201 to 1250 of 1808
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1808

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

p‑AMT/GCST/T-protein↑, 1,   ATF1↓, 1,   IQGAP3↓, 1,   miR-339-5p↑, 1,   miR-339-5p↝, 1,   O-Glc↓, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   SERPINH1/HSP47↓, 1,   SFXN2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 2,   Ferroptosis↑, 2,   GPx↓, 1,   GPx4↓, 2,   GSH↓, 2,   GSTA1↓, 1,   H2O2↑, 2,   HO-1↓, 1,   HO-1↑, 1,   i-Iron↑, 1,   lipid-P↑, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 4,   NRF2↑, 2,   OXPHOS↑, 2,   ROS↓, 1,   ROS↑, 15,   ROS↝, 1,   m-ROS↑, 1,   SOD↓, 2,   TKT↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   i-ATP↓, 1,   CDC25↓, 2,   EGF↓, 1,   MMP↓, 6,   mtDam↑, 2,   OCR↓, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   ALDOA↓, 1,   AMPK↑, 2,   CAIX/CA9↓, 1,   cMyc↓, 1,   p‑CREB↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 6,   HK2↓, 1,   lactateProd↓, 1,   PKM1↑, 1,   PKM2↓, 4,   PPP↓, 1,   TS↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 15,   p‑Akt↓, 5,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 48,   BAX↑, 13,   Bax:Bcl2↑, 1,   Bcl-2↓, 11,   Casp↑, 1,   Casp12↝, 1,   Casp3?, 1,   Casp3↑, 12,   cl‑Casp3↑, 7,   Casp7↑, 5,   Casp8↑, 3,   Casp9↑, 9,   cl‑Casp9↑, 3,   Cyt‑c↑, 6,   DR4↑, 2,   DR5↑, 3,   Fas↑, 1,   Ferroptosis↑, 2,   hTERT/TERT↓, 2,   JNK↑, 3,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↑, 2,   p‑MAPK↑, 1,   p27/CDKN1B↓, 1,   p38↑, 2,   p‑p38↓, 1,   p‑p38↑, 1,   PUMA↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,   tumCV↓, 10,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↑, 3,   ER Stress↑, 4,   GRP78/BiP↑, 3,   IRE1↑, 2,   PERK↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 1,   Beclin-1/ATG6↑, 3,   LC3II↑, 3,   p62↓, 1,   TumAuto↑, 7,   mt-TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 6,   P53↑, 9,   PARP↑, 4,   cl‑PARP↓, 1,   cl‑PARP↑, 7,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   p‑CDK2↓, 1,   CDK4↓, 2,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 3,   P21↑, 1,   PLK1↓, 1,   TumCCA↓, 2,   TumCCA↑, 19,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   CTSB↓, 2,   CTSD↓, 2,   EMT↓, 6,   EMT↑, 1,   ERK↓, 2,   ERK↑, 1,   p‑ERK↓, 2,   FOXO3↓, 1,   GSK‐3β↓, 1,   mTOR↓, 4,   mTOR↑, 2,   p‑mTOR↓, 2,   PI3K↓, 13,   p‑PI3K↓, 2,   PTEN↑, 1,   STAT3↓, 3,   p‑STAT3↓, 1,   TK1↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 6,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 2,   i-Ca+2↑, 1,   CC(CDKs/cyclins)↓, 1,   CD31/PECAM-1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 1,   Ki-67↓, 2,   MMP2↓, 4,   MMP3↓, 1,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↓, 3,   Rac1↓, 1,   Rho↓, 1,   Slug?, 1,   Snail?, 1,   Snail↓, 1,   TGF-β1↓, 1,   TIMP2↓, 1,   TumCI↓, 6,   TumCMig↓, 11,   TumCP↓, 21,   TumCP↑, 1,   TumMeta↓, 6,   TumPF↓, 1,   VEGFR1↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   Hif1a↓, 3,   VEGF↓, 7,   VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   FOXP3↑, 1,   Inflam↓, 2,   JAK2↓, 1,   NF-kB↓, 6,   PSA↓, 2,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 3,   ChemoSen↑, 8,   Dose?, 1,   Dose↝, 6,   eff↓, 4,   eff↑, 3,   RadioS↑, 1,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   hTERT/TERT↓, 2,   Ki-67↓, 2,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   OS↑, 1,   Pin1↓, 3,   Risk↓, 3,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 3,   TumW↓, 1,  
Total Targets: 210

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

antiAll↑, 2,   AntiBio↑, 3,   IRes↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 6,   Catalase↑, 2,   CYP2E1↓, 1,   GPx↑, 2,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 2,   MPO↓, 1,   NRF2↑, 4,   ROS↓, 8,   SOD↑, 3,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   DGAT1↓, 1,   FASN↓, 1,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Akt↝, 1,   Apoptosis↓, 3,   BAX↓, 1,   BMP2↑, 1,   Casp3↓, 1,   Cyt‑c↓, 1,   iNOS↓, 1,   MAPK↓, 1,   p‑MAPK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↑, 1,   RUNX2↑, 1,   STAT↓, 1,  

Migration(tgid=13) ⓘ

COL1↑, 1,   VCAM-1↓, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   eNOS↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   ICAM-1↓, 1,   IL6↓, 1,   Inflam↓, 8,   NF-kB↓, 4,   PGE2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 1,   chemoPv↑, 1,   hepatoP↑, 1,   neuroP↓, 1,   neuroP↑, 3,   toxicity↓, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 69

Scientific Paper Hit Count for: Apoptosis, Apoptosis
69 Curcumin
67 Silver-NanoParticles
45 Magnetic Fields
44 Quercetin
36 Thymoquinone
34 Berberine
34 EGCG (Epigallocatechin Gallate)
32 Sulforaphane (mainly Broccoli)
29 Baicalein
25 Ashwagandha(Withaferin A)
25 Capsaicin
25 Kaempferol
25 Shikonin
23 Betulinic acid
23 Honokiol
23 Phenethyl isothiocyanate
22 Radiotherapy/Radiation
22 Resveratrol
22 Licochalcone A
20 Garcinol
19 Artemisinin
19 Apigenin (mainly Parsley)
19 Boron
19 Chrysin
19 Selenite (Sodium)
18 Cisplatin
18 Dandelion Root
18 Lycopene
18 Urolithin
17 Gambogic Acid
17 Hyperoside
16 Chemotherapy
16 Emodin
16 Eugenol
16 Fisetin
16 Formononetin
15 chitosan
15 Carvacrol
15 Luteolin
15 Nimbolide
14 Astaxanthin
14 Crocetin
14 Ivermectin
13 Beta-Caryophyllene
13 salinomycin
13 Graviola
13 Magnolol
13 Indole-3-carbinol
12 Allicin (mainly Garlic)
12 Metformin
12 chaetocin
12 HydroxyTyrosol
12 Isobavachalcone
12 Juglone
12 Selenium NanoParticles
11 Paclitaxel/Taxol
11 Propolis -bee glue
11 Chlorogenic acid
11 Silymarin (Milk Thistle) silibinin
11 Dichloroacetate
11 Isoliquiritigenin
11 Isovitexin
10 isoquercitrin
10 Copper and Cu NanoParticles
10 Vitamin C (Ascorbic Acid)
10 Alpha-Lipoic-Acid
10 doxorubicin
10 Fucoidan
10 Gallic acid
10 Ginkgetin
10 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
10 isoorientin
10 Phenylbutyrate
10 Piperlongumine
9 Photodynamic Therapy
9 5-fluorouracil
9 α-Bisabolol / Chamomile oil
9 Selenium
9 Cucurbitacin
9 Hydrogen Gas
9 Magnetic Field Rotating
9 Rosmarinic acid
8 Coenzyme Q10
8 Auranofin
8 Gemcitabine (Gemzar)
8 Bufalin/Huachansu
8 Caffeic acid
8 Citric Acid
8 Carvone
8 Cynara scolymus/Globe Artichoke/Artichoke Extract
8 Electrical Pulses
8 Ursolic acid
8 Cynaropicrin
8 Ginkgolide B
7 Atorvastatin
7 Biochanin A
7 borneol
7 Boswellia (frankincense)
7 Carnosic acid
7 Cinnamon
7 Deguelin
7 Lemongrass Extract/Citral
7 Genistein (soy isoflavone)
7 Evodiamine
7 Vitamin K2
6 Astragalus
6 Fenbendazole
6 Andrographis
6 Celecoxib
6 D-limonene
6 Disulfiram
6 Ellagic acid
6 Echinacea
6 Ferulic acid
6 Ginkgo biloba
6 Hibiscus sabdariffa
6 Piperine
6 Parthenolide
6 Terpinen-4-ol / Tea Tree Oil
5 3-bromopyruvate
5 Anethole/trans-Anethole
5 immunotherapy
5 Melatonin
5 Thymol-Thymus vulgaris
5 Celastrol
5 Chlorophyllin
5 Diclofenac
5 Aflavin-3,3′-digallate
5 iodine
5 Vitexin
5 Lactoferrin/Talactoferrin
5 Plumbagin
5 Pterostilbene
4 1,8-Cineole
4 Rutin
4 Gold NanoParticles
4 Ascorbyl Palmitate
4 Berbamine
4 Brucea javanica
4 Bacopa monnieri
4 Bromelain
4 Butyrate
4 Centella asiatica / Gotu kola → asiaticoside
4 Dichloroacetophenone(2,2-)
4 Ginkgo biloba-EGb 761
4 Eurycomanone
4 Galloflavin
4 Geraniol
4 Ginger/6-Shogaol/Gingerol
4 γ-linolenic acid (Borage Oil)
4 Gossypol/AT-101
4 itraconazole
4 Lasiodin
4 Licorice
4 Linalool
4 Spermidine
3 2-DeoxyGlucose
3 Aspirin
3 Dipyridamole
3 tamoxifen
3 Baicalin
3 brusatol
3 Bruteridin(bergamot juice)
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Cat’s Claw
3 Cannabidiol
3 Cichoric acid / Chicoric acid
3 Cyclopamine
3 Date Fruit Extract
3 diet FMD Fasting Mimicking Diet
3 Fennel Oil/Foeniculum vulgare
3 Ginkgolic acids
3 Grapeseed extract
3 HydroxyCitric Acid
3 Orlistat
3 Hyperthermia
3 Inositol
3 isoflavones
3 Lapachol
3 Methyl salicylate / Sweet Birch oil
3 Magnesium
3 Naringin
3 Niclosamide (Niclocide)
3 Sanguinarine
3 Psoralidin
3 α-Santalol/Sandalwood oil
3 Taurine
3 VitK3,menadione
3 Zerumbone
2 cetuximab
2 5-Aminolevulinic acid
2 Ajoene (compound of Garlic)
2 alpha Linolenic acid
2 DTS(dibenzyl trisulphide) from Anamu
2 Sorafenib (brand name Nexavar)
2 Aloe anthraquinones
2 beta-glucans
2 Docetaxel
2 Bortezomib
2 Bullatacin
2 Chocolate
2 Hydroxycinnamic-acid
2 irinotecan
2 Polyphenols
2 CUSP9
2 gefitinib, erlotinib
2 diet Short Term Fasting
2 Folic Acid, Vit B9
2 eicosapentaenoic acid
2 Shilajit/Fulvic Acid
2 hydrogen sulfide
2 Helleborus niger extracts – Christmas Rose
2 Methylglyoxal
2 Oleuropein
2 Oleocanthal
2 Oxygen, Hyperbaric
2 Propyl gallate
2 Sulfasalazine
2 polyethylene glycol
2 Vitamin D3
1 5-Hydroxytryptophan
1 Annona atemoya Leaf Extract
1 Glucose
1 entinostat
1 Trichostatin A
1 Radio Frequency
1 Acetyl-l-carnitine
1 Amodiaquine
1 temozolomide
1 Trastuzumab
1 almonertinib
1 epirubicin
1 Lapatinib
1 bempedoic acid
1 Bifidobacterium
1 Beta‐Lapachone
1 Selenate
1 Prebiotic
1 Choline
1 methotrexate
1 Vitamin E
1 Carica papaya leaf extract
1 Camptothecin
1 chemodynamic therapy
1 Dihydrocaffeic Acid
1 methylseleninic acid
1 diet Methionine-Restricted Diet
1 Dimethyl Sulfoxide
1 Mistletoe/Viscum album Extracts
1 Cannabichromene
1 Tetrahydroxystilbene glucoside
1 Exercise
1 ferumoxytol
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 carboplatin
1 olaparib/LYNPARZA
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginseng
1 Rapamycin
1 High-Ozonide Oil
1 Hops (Humulus lupulus)
1 Huperzine A/Huperzia serrata
1 Inoscavin A
1 Inulin Prebiotic
1 Butein
1 Scopoletin
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Mung Bean Sprouts
1 Lutein
1 Iron
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Mushroom Lion’s Mane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Proanthocyanidins
1 Phenolic Acids
1 Rhein
1 Rauwolfia serpentina/Indian Snakeroot
1 Vorinostat
1 Oxaliplatin
1 Scoulerine
1 acetazolamide
1 Osimertinib
1 Adagrasib
1 Glutathione
1 Tomatine
1 Turmerones
1 Docosahexaenoic Acid
1 Vitamin B3,Niacin
1 Whole Body Vibration
1 xanthohumol
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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