Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Scientific Papers found: Click to Expand⟱
8232- LCA,    Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study
- vitro+vivo, ESCC, NA
TumCP↓, TumCMig↓, TumCI↓, MMPs↓, ROS↑, MMP↓, BAX↑, Casp3↑, Casp9↑, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK1↓, P53↑, TumCG↓, toxicity↓,
8233- LCA,    Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer
- in-vitro, Lung, NA
TumCP↓, selectivity↑, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, BAX↑, PARP1↑, Casp3↑, Bcl-2↓, MAPK↓, FBXO5/EMI1↓, TumVol↓, TumW↓, toxicity↓,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8261- LCA,    Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels
- in-vitro, CRC, T24/HTB-9
TumCP↓, ROS↑, Apoptosis↑, ER Stress↑, i-Ca+2↑, MMP↓, APAF1↑, Casp9↑, Casp3↑, cal2↑, CASP4↑,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑,
8238- LCA,    Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6
- in-vitro, BC, MCF7 - in-vivo, NA, MCF10
PRMT6↓, EstroRS/ERS↓, selectivity?, P53↑, TumCCA↑, Apoptosis↑,
8241- LCA,    Licochalcone A induces apoptotic cell death via JNK/p38 activation in human nasopharyngeal carcinoma cells
- in-vitro, NPC, NA
tumCV↓, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, ERK↑, p38↑, JNK↑,
8243- LCA,    Licochalcone A Inhibits Cellular Motility by Suppressing E-cadherin and MAPK Signaling in Breast Cancer
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, TumAuto↑, Sp1/3/4↓, TumCMig↓, MAPK↓, Akt↓, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, Cyt‑c↑, TumCP↓, ROS↑, Apoptosis↑, TumCMig↓, TumCI↓, MMP↓, γH2AX↑,
8244- LCA,    Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest
- in-vitro, Liver, HepG2
TumCP↓, ROS↑, TumCCA↑, Apoptosis↑, survivin↓, CycB/CCNB1↓, CDK1↓, WEE1↑, P21↑, cycD1/CCND1↑, JNK↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, Casp3↑, Casp8↑, Casp10↑, Fas↑, BAD↑, BAX↑, PUMA↑, PKCδ↓, P70S6K↓, Akt↓,
8245- LCA,    Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity
- in-vivo, LiverDam, NA
*hepatoP↑, *Apoptosis↓, *mtDam↓, *ROS↓, *NRF2↑, *Keap1↓, *ARE↑, *ALAT↓, *AST↓, *MDA↓, *MPO↓, *SOD↑, *GSH/GSSG↑, *Bcl-2↑, *BAX↓, *cl‑Casp3↓, *p‑cJun↓, *AIF↓, *Cyt‑c↓,
8231- LCA,    Maintenance of the Expression of c-FLIPL by Hsp70 to Resist Licochalcone A-Induced Anti-Colorectal Cancer Effect through ERK-Mediated Autophagy Induction
- in-vitro, CRC, NA
TumCP↓, Apoptosis↑, HSP70/HSPA5↓, cFLIP↓, ERK↑, p38↑,
8249- LCA,    Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells
tumCV↓, LDH↑, Apoptosis↑, selectivity↑, LC3II↑, TumAuto↑, ER Stress↑, CHOP/DDIT3↑, chemoP↑, RenoP↑, cl‑PARP↑, cl‑Casp7↑, cl‑Casp3↑,
8253- LCA,    Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma
- in-vitro, SCC, HSC4
*AntiTum↑, *angioG↓, *AntiP↑, *antiOx↑, *Bacteria↓, *Inflam↓, tumCV↓, Sp1/3/4↓, p27/CDKN1B↑, P21↑, cycD1/CCND1↓, Mcl-1↓, survivin↓, Apoptosis↑,
8259- LCA,    Modulation of bcl-2 and cytotoxicity by licochalcone-A, a novel estrogenic flavonoid
- in-vitro, BC, MCF7 - in-vitro, AML, HL-60
ChemoSen↑, Apoptosis↑, cl‑PARP↑, Bcl-2↓, Bax:Bcl2↑,
8207- LCA,    Licochalcone a Induces ROS-Mediated Apoptosis through TrxR1 Inactivation in Colorectal Cancer Cells
- in-vitro, CRC, HCT116
ROS↑, TumCCA↑, Apoptosis↑, eff↓, TrxR1↓, cDC2↓, Bcl-2↓, BAX↑, NRF2↓, p‑ASK1↑,
8208- LCA,    Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells
- in-vitro, BC, MCF7
*Inflam↓, *AntiCan↑, *AntiP↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, Casp3↑, Bcl-2↓, TumAuto↑, Apoptosis↑, tumCV?,
8209- LCA,    Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells
- in-vitro, Ovarian, SKOV3
tumCV↓, TumCCA↑, ROS↑, MMP↓, Apoptosis↑, cl‑Casp↑, Cyt‑c↑, STAT3↓, TumCP↓, Dose↝, p‑STAT3↓,
8210- LCA,    Licochalcone A-Induced Human Bladder Cancer T24 Cells Apoptosis Triggered by Mitochondria Dysfunction and Endoplasmic Reticulum Stress
- in-vitro, Bladder, T24/HTB-9
chemoPv↑, TumCP↓, ROS↑, Apoptosis↑, mtDam↑, Casp3↑, cl‑PARP↑, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, Casp12↑, mt-ROS↑, tumCV↓, GSH/GSSG↓, NA↓,
8211- LCA,    Licochalcone A induces endoplasmic reticulum stress-mediated apoptosis of endometrial cancer cells via upregulation of GRP78 expression
- in-vitro, EC, NA
AntiCan↑, tumCV↓, Apoptosis↑, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑,
8223- LCA,    Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells
- in-vitro, Nor, RAW264.7
*Apoptosis↓, *ROS↓, *GSH↑, *GCLM↑, *GCLC↑, *HO-1↑, *NRF2↑, *Keap1↓, *ARE↑, *Akt↑, *ERK↑, *PI3K↑,
8225- LCA,  Cisplatin,    Licochalcone A protects against cisplatin-induced acute kidney injury via the modulation of Nrf2/Keap1-mediated ferroptosis and apoptosis
- in-vivo, Nor, NA
*RenoP↑, *Urea↓, *BUN↓, *creat↓, *Apoptosis↓, *Ferroptosis↓, *Iron↓, *ROS↓, *lipid-P↓, *mtDam↓, *NRF2↑,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
8265- LE,    Glycyrrhizin ameliorates colorectal cancer progression by regulating NHEJ pathway through inhibiting HMGB1-induced DNA damage response
- vitro+vivo, CRC, NA
TumCG↓, Inflam↓, tumCV↓, DNAdam↑, Apoptosis↑, Casp3↑, TumCCA↑, cycD1/CCND1↓, HMGB1↓, NHEJ↓, TumCP↓,
8262- LE,    Phytochemical profiling, antimicrobial, cytotoxic and apoptotic effects of Glycyrrhiza glabra ethanolic extract
- in-vitro, Liver, HepG2
*Dose↝, *AntiBio↑, Dose↝, P53↑, BAX↑, Bcl-2↓, Apoptosis↑,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
1306- LE,    Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell
- in-vitro, BC, MCF7
Bcl-2↓, BAX↑, Apoptosis↑, TumCCA↑,
8130- LF,    Lactoferrin targeting INTL1 receptor inhibits hepatocellular carcinoma progression via apoptosis and cell cycle signaling pathways
- in-vitro, HCC, HepG2 - in-vitro, HCC, HepG3 - in-vitro, HCC, SK-HEP-1
Iron↓, TumCP↓, selectivity↑, TumCCA↑, p‑MAPK↑, JNK↑, Apoptosis↑,
8145- LF,    Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review
- Review, AD, NA - Review, Park, NA
*AntiBio↑, *Imm↑, *AntiCan↑, *neuroP↑, *BBB↑, *APOE4↓, *ROS↓, *Inflam↓, *Apoptosis↓, *Learn↑, *memory↑, *ADAM10↑, *PSEN1/PS1↑, *cl‑APP↑, *BACE/β-secretase↓, *cognitive↑, *MDA↓, *IL6↓, *TNF-α↓, *neuroP↑, *Dose↝, *IronCh↑, *SOD↑, *BioAv↝,
8132- LF,    Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase
- in-vitro, BC, HS587T - in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D - in-vitro, BC, MCF10
Iron↓, AntiCan↑, Apoptosis↑, selectivity↑, ECAR↓, i-pH↑, ATPase↓,
8134- LF,    Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways
- in-vitro, CRC, HT-29
Iron↓, Apoptosis↑, selectivity↑, Casp8↑, P53↑, P21↑,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8199- LGE,    Citral is a new inducer of caspase-3 in tumor cell lines
Dose↑, Apoptosis↑, DNAdam↑, Casp3↑,
8193- LGE,    Targets and pathways involved in the antitumor activity of citral and its stereo-isomers
- Review, Var, NA
TumCP↓, Apoptosis↑, ROS↑, DNAdam↑, MARK4↓, ALDH1A3↓, CSCs↓, chemoR↓, BioAv↓, selectivity↝,
8192- LGE,    Essential Oils of Lemongrass (Cymbopogon citratus Stapf) Induces Apoptosis and Cell Cycle Arrest in A549 Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H1975
Dose↝, TumCD↑, Apoptosis↑, TumCCA↑, Apoptosis↑,
8189- LGE,    Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects
- vitro+vivo, CRC, NA
Apoptosis↑, Dose↝, selectivity↑, eff↑,
8188- LGE,    Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells
- in-vitro, BC, MCF7
TumCG↓, TumCCA↑, Apoptosis↑, PGE2↓,
8187- LGE,    Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation
- in-vitro, BC, 4T1 - in-vitro, Ovarian, OVCAR-3 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Bcl-2↓, ER Stress↑, CHOP/DDIT3↑, GADD45A↑, EDEM↑, ATF4↑, HSP90↑, ATG5↑, eIF2α↑, ROS↑, P53↑, eff↓,
6484- LIN,    Linalool Inhibits MCF-7 Tumor Growth in a Xenograft Model by Apoptosis Induction and Immune Modulation
- vitro+vivo, BC, MCF7
TumCG↓, Apoptosis↑, ROS↓, TumCCA↑,
6479- LIN,    Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer
- in-vivo, Colon, HCT116
Apoptosis↑, ROS↑, lipid-P↑, selectivity↑, TumCP↓, *toxicity↓,
6481- LIN,    Linalool inhibits 22Rv1 prostate cancer cell proliferation and induces apoptosis
- in-vivo, Pca, 22Rv1
TumCP↓, Apoptosis↑, Ki-67↓, PCNA↓, TumCCA↑, MMP↓, TumCG↓,
6483- LIN,    Linalool-Incorporated Nanoparticles as a Novel Anticancer Agent for Epithelial Ovarian Carcinoma
- in-vitro, Ovarian, A2780S
Apoptosis↑, ROS↑, MMP↓, Casp3↑, TumW↓, ChemoSen↑, EPR↑,
7825- LT,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *OS↑, *antiOx↑, *Aβ42↓, *AChE↓, *Aβ↓, *IRes↓, *p‑tau↓, *ROS↓, *Apoptosis↓, *Inflam↓, *Iron↝,
1025- LT,  Api,    Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer
- in-vivo, Lung, NA
TumCG↓, Apoptosis↑, PD-L1↓, p‑STAT3↓,
1100- LT,    Luteolin, a flavonoid, as an anticancer agent: A review
- Review, NA, NA
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, ROS↑, ER Stress↑, mtDam↑, p‑eIF2α↝, p‑PERK↝, p‑CHOP/DDIT3↝, p‑ATF4↝, cl‑Casp12↝,
973- LT,    Luteolin impairs hypoxia adaptation and progression in human breast and colon cancer cells
- in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-231
Apoptosis↑, necrosis↑, TumAuto↑, HIF-1↓,
2925- LT,    Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3
- in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293 - in-vitro, BC, MCF7
HSP90↓, p‑STAT3↓, Apoptosis↑, selectivity↑,
2923- LT,    Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells
- in-vitro, NA, NA
Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2909- LT,    Revisiting luteolin: An updated review on its anticancer potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, TumCP↓, chemoP↑, MDR1↓,
2913- LT,    Luteolin induces apoptosis by impairing mitochondrial function and targeting the intrinsic apoptosis pathway in gastric cancer cells
- in-vitro, GC, HGC27 - in-vitro, BC, MCF7 - in-vitro, GC, MKN45
TumCP↓, MMP↓, Apoptosis↑, ROS↑, SOD↓, ATP↓, Bax:Bcl2↑, TumCCA↑,

Showing Research Papers: 1251 to 1300 of 1808
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1808

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ALDH1A3↓, 1,   ATG13↑, 1,   ATG16L1↑, 1,   CASP4↑, 1,   EDEM↑, 1,   FBXO5/EMI1↓, 1,   NA↓, 1,   NHEJ↓, 1,   PRMT6↓, 1,   RUBCN↓, 1,   THEM4/CTMP↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   ULK1/ATG1↑, 1,   WEE1↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx⇅, 1,   CYP1A1↓, 1,   Ferroptosis↑, 1,   GSH/GSSG↓, 1,   Iron↓, 3,   Iron↝, 1,   lipid-P↑, 1,   NRF2↓, 1,   ROS↓, 2,   ROS↑, 17,   mt-ROS↑, 1,   SOD↓, 1,   TrxR1↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 3,   CDC2↓, 1,   CDC25↓, 1,   MKK4↓, 1,   MKK7↓, 1,   MMP↓, 12,   mtDam↑, 4,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATG7↑, 1,   ECAR↓, 1,   FASN↓, 1,   Glycolysis↓, 2,   HK2↓, 2,   LDH↑, 1,   PDK1 / PDPK1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   p‑Akt↓, 1,   APAF1↑, 3,   Apoptosis?, 1,   Apoptosis↑, 43,   mt-Apoptosis↑, 1,   p‑ASK1↑, 1,   BAD↑, 2,   BAX↑, 11,   Bax:Bcl2↑, 3,   Bcl-2↓, 11,   Bcl-xL↓, 2,   BIM↑, 1,   Casp↑, 2,   cl‑Casp↑, 1,   Casp10↑, 1,   Casp12↑, 2,   cl‑Casp12↝, 1,   Casp3↑, 13,   cl‑Casp3↑, 4,   cl‑Casp7↑, 2,   Casp8↑, 3,   Casp9↑, 4,   cl‑Casp9↑, 2,   cFLIP↓, 2,   Cyt‑c↑, 6,   DR5↑, 3,   Fas↑, 3,   FasL↑, 1,   Ferroptosis↑, 1,   IAP1↓, 1,   iNOS↓, 1,   JNK↓, 2,   JNK↑, 4,   MAPK↓, 4,   p‑MAPK↑, 1,   Mcl-1↓, 1,   MDM2↓, 1,   necrosis↑, 1,   p27/CDKN1B↑, 2,   p38↑, 4,   PUMA↑, 1,   RIP1↓, 1,   survivin↓, 4,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,   Sp1/3/4↓, 4,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   tumCV?, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑ATF6↑, 1,   CHOP/DDIT3↑, 7,   p‑CHOP/DDIT3↝, 1,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 1,   p‑eIF2α↝, 1,   ER Stress↑, 9,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 3,   HSP90↑, 1,   PERK↑, 2,   p‑PERK↝, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 2,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↑, 3,   p62↓, 1,   p62↑, 1,   TumAuto↑, 6,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 4,   GADD45A↑, 1,   P53↑, 7,   cl‑PARP↑, 7,   PARP1↑, 1,   PCNA↓, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK2↓, 3,   CDK4↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 5,   cycD1/CCND1↑, 2,   cycE/CCNE↓, 2,   P21↑, 5,   TumCCA↑, 22,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   cDC2↓, 1,   p‑cMET↑, 1,   CSCs↓, 1,   EMT↓, 1,   ERK↓, 2,   ERK↑, 4,   p‑GSK‐3β↓, 1,   IGF-1↓, 1,   mTOR↓, 5,   P70S6K↓, 3,   PI3K↓, 7,   STAT3↓, 2,   p‑STAT3↓, 3,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 6,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

ATPase↓, 1,   Ca+2↑, 2,   i-Ca+2↑, 1,   cal2↑, 1,   CD31/PECAM-1↓, 1,   E-cadherin↑, 2,   FAK↓, 1,   Ki-67↓, 1,   MARK4↓, 1,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP3↓, 2,   MMP9↓, 1,   MMPs↓, 1,   N-cadherin↓, 2,   PDGF↓, 1,   PKCδ↓, 4,   Snail↓, 1,   TSC1↑, 1,   TumCI↓, 5,   TumCMig↓, 5,   TumCP↓, 21,   TumMeta↓, 3,   Twist↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   ATF4↑, 2,   p‑ATF4↝, 1,   EGFR↓, 3,   EPR↑, 1,   HIF-1↓, 1,   Hif1a↓, 3,   VEGF↓, 3,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 2,   Imm↝, 1,   Inflam↓, 3,   NF-kB↓, 3,   PD-L1↓, 3,   PGE2↓, 1,   T-Cell↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

i-pH↑, 1,  

Protein Aggregation(tgid=19) ⓘ

PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

EstroRS/ERS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 1,   BioEnh↑, 1,   chemoR↓, 1,   ChemoSen↑, 2,   CYP1A2↓, 1,   Dose↑, 2,   Dose↝, 6,   eff↓, 2,   eff↑, 2,   MDR1↓, 1,   P450↓, 1,   selectivity?, 1,   selectivity↑, 8,   selectivity↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 3,   EstroRS/ERS↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 1,   Ki-67↓, 1,   LDH↑, 1,   PD-L1↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   chemoP↑, 4,   chemoPv↑, 1,   PRAS40↑, 1,   RenoP↑, 1,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 2,  
Total Targets: 238

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

anemia↓, 1,   AntiArt↑, 1,   AntiBio↑, 2,   AntiP↑, 4,   APOE4↓, 1,   Aβ42↓, 2,   FPN↑, 1,   IRes↓, 1,   Learn↑, 1,   PSEN1/PS1↑, 1,   RBC↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   ARE↑, 2,   Catalase↑, 2,   Fenton↓, 1,   Ferroptosis↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 2,   GSH↑, 2,   GSH/GSSG↑, 1,   GSR↑, 1,   GSTA1↑, 1,   HO-1↑, 2,   Iron↓, 1,   Iron↝, 1,   Keap1↓, 2,   lipid-P↓, 3,   MDA↓, 2,   MPO↓, 1,   NRF2↑, 6,   ROS↓, 8,   SOD↑, 5,   TAC↑, 2,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   mtDam↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   BUN↓, 1,   glucose↝, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   Apoptosis↓, 6,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   cl‑Casp3↓, 1,   Cyt‑c↓, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↓, 1,   other↓, 1,   other↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   PI3K↑, 1,   PTEN↓, 1,  

Migration(tgid=13) ⓘ

cl‑APP↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL10↓, 1,   IL6↓, 3,   Imm↑, 1,   Inflam↓, 9,   IκB?, 1,   NF-kB↓, 2,   PGE2↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   ADAM10↑, 1,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 2,   ChemoSen↑, 1,   Dose↝, 2,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BMD↑, 1,   creat↓, 1,   Ferritin↓, 1,   GutMicro↑, 1,   HemoG↑, 1,   IL6↓, 3,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 4,   Obesity↓, 1,   OS↑, 1,   RenoP↑, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 2,   Sepsis↓, 1,  
Total Targets: 109

Scientific Paper Hit Count for: Apoptosis, Apoptosis
69 Curcumin
67 Silver-NanoParticles
45 Magnetic Fields
44 Quercetin
36 Thymoquinone
34 Berberine
34 EGCG (Epigallocatechin Gallate)
32 Sulforaphane (mainly Broccoli)
29 Baicalein
25 Ashwagandha(Withaferin A)
25 Capsaicin
25 Kaempferol
25 Shikonin
23 Betulinic acid
23 Honokiol
23 Phenethyl isothiocyanate
22 Radiotherapy/Radiation
22 Resveratrol
22 Licochalcone A
20 Garcinol
19 Artemisinin
19 Apigenin (mainly Parsley)
19 Boron
19 Chrysin
19 Selenite (Sodium)
18 Cisplatin
18 Dandelion Root
18 Lycopene
18 Urolithin
17 Gambogic Acid
17 Hyperoside
16 Chemotherapy
16 Emodin
16 Eugenol
16 Fisetin
16 Formononetin
15 chitosan
15 Carvacrol
15 Luteolin
15 Nimbolide
14 Astaxanthin
14 Crocetin
14 Ivermectin
13 Beta-Caryophyllene
13 salinomycin
13 Graviola
13 Magnolol
13 Indole-3-carbinol
12 Allicin (mainly Garlic)
12 Metformin
12 chaetocin
12 HydroxyTyrosol
12 Isobavachalcone
12 Juglone
12 Selenium NanoParticles
11 Paclitaxel/Taxol
11 Propolis -bee glue
11 Chlorogenic acid
11 Silymarin (Milk Thistle) silibinin
11 Dichloroacetate
11 Isoliquiritigenin
11 Isovitexin
10 isoquercitrin
10 Copper and Cu NanoParticles
10 Vitamin C (Ascorbic Acid)
10 Alpha-Lipoic-Acid
10 doxorubicin
10 Fucoidan
10 Gallic acid
10 Ginkgetin
10 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
10 isoorientin
10 Phenylbutyrate
10 Piperlongumine
9 Photodynamic Therapy
9 5-fluorouracil
9 α-Bisabolol / Chamomile oil
9 Selenium
9 Cucurbitacin
9 Hydrogen Gas
9 Magnetic Field Rotating
9 Rosmarinic acid
8 Coenzyme Q10
8 Auranofin
8 Gemcitabine (Gemzar)
8 Bufalin/Huachansu
8 Caffeic acid
8 Citric Acid
8 Carvone
8 Cynara scolymus/Globe Artichoke/Artichoke Extract
8 Electrical Pulses
8 Ursolic acid
8 Cynaropicrin
8 Ginkgolide B
7 Atorvastatin
7 Biochanin A
7 borneol
7 Boswellia (frankincense)
7 Carnosic acid
7 Cinnamon
7 Deguelin
7 Lemongrass Extract/Citral
7 Genistein (soy isoflavone)
7 Evodiamine
7 Vitamin K2
6 Astragalus
6 Fenbendazole
6 Andrographis
6 Celecoxib
6 D-limonene
6 Disulfiram
6 Ellagic acid
6 Echinacea
6 Ferulic acid
6 Ginkgo biloba
6 Hibiscus sabdariffa
6 Piperine
6 Parthenolide
6 Terpinen-4-ol / Tea Tree Oil
5 3-bromopyruvate
5 Anethole/trans-Anethole
5 immunotherapy
5 Melatonin
5 Thymol-Thymus vulgaris
5 Celastrol
5 Chlorophyllin
5 Diclofenac
5 Aflavin-3,3′-digallate
5 iodine
5 Vitexin
5 Lactoferrin/Talactoferrin
5 Plumbagin
5 Pterostilbene
4 1,8-Cineole
4 Rutin
4 Gold NanoParticles
4 Ascorbyl Palmitate
4 Berbamine
4 Brucea javanica
4 Bacopa monnieri
4 Bromelain
4 Butyrate
4 Centella asiatica / Gotu kola → asiaticoside
4 Dichloroacetophenone(2,2-)
4 Ginkgo biloba-EGb 761
4 Eurycomanone
4 Galloflavin
4 Geraniol
4 Ginger/6-Shogaol/Gingerol
4 γ-linolenic acid (Borage Oil)
4 Gossypol/AT-101
4 itraconazole
4 Lasiodin
4 Licorice
4 Linalool
4 Spermidine
3 2-DeoxyGlucose
3 Aspirin
3 Dipyridamole
3 tamoxifen
3 Baicalin
3 brusatol
3 Bruteridin(bergamot juice)
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Cat’s Claw
3 Cannabidiol
3 Cichoric acid / Chicoric acid
3 Cyclopamine
3 Date Fruit Extract
3 diet FMD Fasting Mimicking Diet
3 Fennel Oil/Foeniculum vulgare
3 Ginkgolic acids
3 Grapeseed extract
3 HydroxyCitric Acid
3 Orlistat
3 Hyperthermia
3 Inositol
3 isoflavones
3 Lapachol
3 Methyl salicylate / Sweet Birch oil
3 Magnesium
3 Naringin
3 Niclosamide (Niclocide)
3 Sanguinarine
3 Psoralidin
3 α-Santalol/Sandalwood oil
3 Taurine
3 VitK3,menadione
3 Zerumbone
2 cetuximab
2 5-Aminolevulinic acid
2 Ajoene (compound of Garlic)
2 alpha Linolenic acid
2 DTS(dibenzyl trisulphide) from Anamu
2 Sorafenib (brand name Nexavar)
2 Aloe anthraquinones
2 beta-glucans
2 Docetaxel
2 Bortezomib
2 Bullatacin
2 Chocolate
2 Hydroxycinnamic-acid
2 irinotecan
2 Polyphenols
2 CUSP9
2 gefitinib, erlotinib
2 diet Short Term Fasting
2 Folic Acid, Vit B9
2 eicosapentaenoic acid
2 Shilajit/Fulvic Acid
2 hydrogen sulfide
2 Helleborus niger extracts – Christmas Rose
2 Methylglyoxal
2 Oleuropein
2 Oleocanthal
2 Oxygen, Hyperbaric
2 Propyl gallate
2 Sulfasalazine
2 polyethylene glycol
2 Vitamin D3
1 5-Hydroxytryptophan
1 Annona atemoya Leaf Extract
1 Glucose
1 entinostat
1 Trichostatin A
1 Radio Frequency
1 Acetyl-l-carnitine
1 Amodiaquine
1 temozolomide
1 Trastuzumab
1 almonertinib
1 epirubicin
1 Lapatinib
1 bempedoic acid
1 Bifidobacterium
1 Beta‐Lapachone
1 Selenate
1 Prebiotic
1 Choline
1 methotrexate
1 Vitamin E
1 Carica papaya leaf extract
1 Camptothecin
1 chemodynamic therapy
1 Dihydrocaffeic Acid
1 methylseleninic acid
1 diet Methionine-Restricted Diet
1 Dimethyl Sulfoxide
1 Mistletoe/Viscum album Extracts
1 Cannabichromene
1 Tetrahydroxystilbene glucoside
1 Exercise
1 ferumoxytol
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 carboplatin
1 olaparib/LYNPARZA
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginseng
1 Rapamycin
1 High-Ozonide Oil
1 Hops (Humulus lupulus)
1 Huperzine A/Huperzia serrata
1 Inoscavin A
1 Inulin Prebiotic
1 Butein
1 Scopoletin
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Mung Bean Sprouts
1 Lutein
1 Iron
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Mushroom Lion’s Mane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Proanthocyanidins
1 Phenolic Acids
1 Rhein
1 Rauwolfia serpentina/Indian Snakeroot
1 Vorinostat
1 Oxaliplatin
1 Scoulerine
1 acetazolamide
1 Osimertinib
1 Adagrasib
1 Glutathione
1 Tomatine
1 Turmerones
1 Docosahexaenoic Acid
1 Vitamin B3,Niacin
1 Whole Body Vibration
1 xanthohumol
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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