TumCP Cancer Research Results

TumCP, Tumor Cell proliferation: Click to Expand ⟱
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Tumor cell proliferation is a key characteristic of cancer. It refers to the rapid and uncontrolled growth of cells that can lead to the formation of tumors.
Scientific Papers found: Click to Expand⟱
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
- in-vitro, PC, NA
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2/PTGS2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1/CCL2↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3431- TQ,    PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Glycolysis↓, Warburg↓, HK2↓, ATP↓, NADPH↓, PI3K↓, Akt↓, TumCP↓, E-cadherin↑, N-cadherin↓, Hif1a↓, PKM2↓, GlucoseCon↓, lactateProd↓, EMT↓,
3421- TQ,    Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer
- Analysis, Nor, NA - in-vivo, Nor, NA - in-vitro, BC, MCF7 - in-vitro, Nor, HaCaT
HDAC↓, P21↑, Maspin↑, BAX↑, B2M↓, TumCCA↑, selectivity↑, *toxicity↓, TumCMig↓, TumCP↓,
3417- TQ,    Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress
- in-vitro, BC, MCF7 - in-vitro, Liver, HepG2
TumCP↓, NF-kB↓, cl‑Casp3↑, GRP78/BiP↑, ER Stress↑, Apoptosis↑,
3416- TQ,    Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, 253J - in-vitro, Nor, SV-HUC-1
TumCP↓, Apoptosis↑, ER Stress↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp7↑, cl‑PARP↑, Cyt‑c↑, PERK↑, IRE1↑, ATF6↑, p‑eIF2α↑, ATF4↑, GRP78/BiP↑, CHOP/DDIT3↑,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, Synergy↑, DNAdam↑, *iNOS↓,
3747- TTT,    Tumor treating induced fields: a new treatment option for patients with glioblastoma
- in-vitro, GBM, U87MG
*TumCP↑,
6456- TUR,    Ar-turmerone inhibits the proliferation and mobility of glioma by downregulating cathepsin B
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCP↓, TumCCA↑, CTSB↓, cl‑p27/CDKN1B↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
5911- TV,    Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway
- vitro+vivo, CRC, NA
TumCP↓, Apoptosis↑, TumVol↓, Bax:Bcl2↑, EMT↓, TumCI↓, TumMeta↓, Wnt/(β-catenin)↓,
1020- UA,    Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting Wnt/β-Catenin Pathway
- in-vitro, Melanoma, RPMI-8226
β-catenin/ZEB1↓, TCF↓, cMyc↓, cycD1/CCND1↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, Casp7↑,
5019- UA,    Ursolic acid in colorectal cancer: mechanisms, current status, challenges, and future research directions
- Review, Var, NA
TumCP↓, Diff↑, Apoptosis↑, TumCI↓, angioG↓,
5021- UA,    Anticancer effect of ursolic acid via mitochondria-dependent pathways
- Review, Var, NA
Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2/PTGS2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2/PTGS2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2/PTGS2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
4840- Uro,    Urolithin A: A promising selective estrogen receptor modulator and 27-hydroxycholesterol attenuator in breast cancer
- vitro+vivo, BC, NA
MMP↓, TumCP↓, Apoptosis↑, tumCV↓, ER-α36↝, *toxicity↓,
4841- Uro,    Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
TumCP↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, Bcl-2↓, Cyt‑c↑, Casp↑, ROS↑, *ROS↓,
4842- Uro,    Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, MCF7 - in-vitro, BC, 4T1
Inflam↓, IL6↓, TNF-α↓, Synergy↑, STAT3↓, TumCP↓, TumCMig↓,
4843- Uro,    The effects of urolithins on the response of prostate cancer cells to non-steroidal antiandrogen bicalutamide
- in-vitro, Pca, LNCaP
TumCP↓, eff↑, ChemoSen↝,
4847- Uro,    Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells
- in-vitro, CRC, SW-620
TumCP↓, TumCMig↓, MMP9↓, TumAuto↑, Apoptosis↑, TumCCA↓, TumMeta↓, ChemoSen↓,
4849- Uro,    Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway
- vitro+vivo, GC, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, TumAuto↑, TumCG↓, chemoP↑, ChemoSen↑,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,
8159- UsA,    Usnic acid suppresses cervical cancer cell proliferation by inhibiting PD-L1 expression and enhancing T-lymphocyte tumor-killing activity
- in-vitro, Cerv, HeLa
STAT3↓, RAS↓, mTOR↓, PD-L1↓, TumCP↓, angioG↓, TumCMig↓, TumCI↓, TumCG↓,
3143- VitC,  ATO,    Vitamin C enhances the sensitivity of osteosarcoma to arsenic trioxide via inhibiting aerobic glycolysis
- in-vitro, OS, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Glycolysis↓, lactateProd↓, ATP↓, PGK1↓, PGM1↓, LDHA↓,
3133- VitC,    Vitamin C supplementation had no side effect in non-cancer, but had anticancer properties in ovarian cancer cells
- in-vitro, Ovarian, NA
*SVCT-2↑, *GLUT1↓, SVCT-2↓, GLUT1↑, TumCP↓, CDK2↓, PARP↓, selectivity↑,
1739- VitD3,    Effect of Vitamin D3 Supplements on Development of Advanced Cancer
- Trial, Var, NA
AntiCan↑, Dose↝, Risk↓, TumCP↓, Inflam↓, eff∅,
115- VitD3,    Vitamin D3 Inhibits Hedgehog Signaling and Proliferation in Murine Basal Cell Carcinomas
- in-vivo, RCC, NA - in-vivo, BCC, NA
HH↓, GLI2↓, Shh↓, Gli1↓, Ki-67↓, TumCP↓,
1833- VitK2,    Divergent effects of vitamins K1 and K2 on triple negative breast cancer cells
- in-vitro, BC, HS587T - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SUM159
TumCP↓, other↑,
1829- VitK2,    Vitamin K: New insights related to senescence and cancer metastasis
- Review, Var, NA
TumCP↓, TumCG↓, ChemoSen↑, ROS↑,
1823- VitK2,  VitK3,    Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells
- in-vitro, CRC, NA - in-vivo, NA, NA
TumCP↓, TumCCA↑, Casp3↑,
1816- VitK2,    Role of Vitamin K in Selected Malignant Neoplasms in Women
- Review, Var, NA
TumCP↓, TumMeta↓, TumAuto↑, Apoptosis↑, Apoptosis↑, Casp3↑, Casp7↑, ROS↑, AR↓, EMT↓, Wnt↓, MMP↓, Cyt‑c↑, NF-kB↓, cycD1/CCND1↓, TumCCA↓,
1213- VitK2,    Vitamin K2 Inhibits Hepatocellular Carcinoma Cell Proliferation by Binding to 17β-Hydroxysteroid Dehydrogenase 4
- in-vitro, HCC, HepG2
HSD17B4↓, Akt↓, MEK↓, ERK↓, STAT3↓, TumCP↓,
1834- VitK3,  PDT,    Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells
- in-vitro, Melanoma, A431
Synergy↑, TumCG↓, TumCP↓, ROS↑, MMP↓,
1839- VitK3,    Vitamin K3 derivative inhibits androgen receptor signaling in targeting aggressive prostate cancer cells
- in-vitro, Pca, NA
TumCP↓, Apoptosis↑, TumCCA↑, ROS↑, eff↓, AR↓, Trx↓, Bcl-2↓,
7887- VT,  IVT,    Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,
9149- WN,    Mechanistic examination of walnuts in prevention of breast cancer
- in-vitro, BC, MCF7
Ingr↝, TumCP↓, NR1H4↑,
9145- WN,    Dietary walnut altered gene expressions related to tumor growth, survival, and metastasis in breast cancer patients: a pilot clinical trial
- Trial, BC, NA
Dose?, Apoptosis↑, TumCA↓, TumCP↓, TumCMig↓, eff↑, Synergy↑,
9144- WN,    Walnuts Have Potential for Cancer Prevention and Treatment in Mice
- Review, Var, NA
Ingr↝, TumCG↓, TumNum↓, TumCP↓, angioG↓, Ingr↝, Ingr↝, Risk↓,
2621- Wog,    Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review
- Review, Var, NA
Hif1a↓, MCT4↓, LDH↓, lactateProd↓, ECAR↓, TumCP↓, Glycolysis↓,
4890- ZER,    Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite
- in-vitro, Nor, RAW264.7
*iNOS↓, *COX2/PTGS2↓, *EP2↓, TumCP↓, selectivity↑, Apoptosis↑, *chemoP↑, *Inflam↓,
4889- ZER,    Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha
- in-vitro, CRC, HCT116
TumCP↓, TNF-α↓, *toxicity↝,
4886- ZER,    Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio
- in-vitro, Liver, HepG2
TumCP↓, Apoptosis↑, BAX↑, Bcl-2↓, *selectivity↑,
9131- ZYF,    Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets
- vitro+vivo, PC, NA
TumCP↓, ChemoSen↑, Apoptosis↑, NF-kB↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, Bcl-2↓, IAP1↓, VEGF↓, survivin↓, ICAM-1↓, CXCR4↓, TumCG↓, Ki-67↓, MMP9↓,
9132- ZYF,    Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cells
- in-vitro, Melanoma, NA
TumCP↓, TumCI↓, angioG↓, TumMeta↓, Inflam↓, TumCG↓, Apoptosis↑,
9133- ZYF,    Zyflamend induces apoptosis in pancreatic cancer cells via modulation of the JNK pathway
- in-vitro, PC, NA
TumCP↓, Apoptosis↑, TumCCA↑, ER Stress↑, TumAuto↑, JNK↑, Synergy↑, cl‑Casp3↑, cl‑PARP↑, p‑Akt↓, ERK↓, PERK↑, eIF2α↑, p‑IRE1↑, CHOP/DDIT3↑, AMPK↑,
9129- ZYF,    Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation
- in-vitro, Pca, PC3
Inflam↓, COX1↓, COX2/PTGS2↓, 5LO↓, 5-HETE↓, TumCP↓, TumCCA↑, Apoptosis↑, 12LOX↓, p‑P21↑, pRB↓,

Showing Research Papers: 1251 to 1300 of 1302
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1302

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 2,   NA↑, 4,   NA↝, 1,   NA?, 1,   NA∅, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 2,   antiOx↓, 5,   antiOx↑, 25,   antiOx⇅, 2,   ARE↑, 1,   ARE/EpRE↑, 1,   Catalase↓, 9,   Catalase↑, 7,   DJ-1↓, 1,   ENOX2↑, 1,   Fenton↑, 4,   GCLC↑, 2,   GPx↓, 4,   GPx↑, 7,   GPx1↓, 1,   GPx4↓, 30,   GPx4↑, 2,   GSH↓, 60,   GSH↑, 12,   GSH/GSSG↓, 10,   GSR↓, 1,   GSR↑, 3,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 5,   H2O2↓, 3,   H2O2↑, 8,   mt-H2O2↑, 1,   HO-1↓, 9,   HO-1↑, 22,   HO-2↓, 1,   Iron↓, 3,   Iron↑, 19,   i-Iron↑, 5,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 2,   lipid-P↓, 10,   lipid-P↑, 41,   lipid-P↝, 1,   MDA↓, 4,   MDA↑, 20,   i-MDA↑, 2,   MPO↓, 1,   NADH↓, 2,   mt-NADH↑, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 6,   Nrf1↑, 1,   NRF2↓, 27,   NRF2↑, 33,   NRF2↝, 1,   Prx↓, 1,   Prx3↑, 1,   Prx6↑, 1,   PrxII↓, 2,   RNS↑, 1,   ROS?, 3,   ROS↓, 38,   ROS↑, 412,   ROS⇅, 9,   ROS↝, 6,   ROS∅, 1,   i-ROS↑, 2,   mt-ROS↓, 2,   mt-ROS↑, 15,   selenoP↓, 1,   SOD↓, 13,   SOD↑, 11,   SOD1↓, 4,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 4,   mt-SOD2↑, 1,   TAC↓, 1,   TBARS↓, 1,   Thiols↓, 2,   i-Thiols↓, 1,   TKT↓, 1,   TKT↝, 1,   Trx↓, 3,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 9,   TrxR1↓, 5,   TrxR1↑, 1,   xCT/SLC7A11↓, 10,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↝, 1,   FTH1↓, 5,   IronCh↑, 4,   LIP↑, 1,   NCOA4↑, 2,   SFXN2↓, 1,   Tf↑, 2,   TfR1/CD71↓, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   BCR-ABL↓, 1,   CDC2↓, 5,   CDC25↓, 15,   CDC25↝, 1,   compI↓, 6,   compII↓, 1,   compIII↓, 3,   compV↓, 1,   EGF↓, 4,   ETC↓, 6,   HSP60/HSPD1↓, 2,   Insulin↓, 3,   KIF2C↓, 1,   mitResp↓, 6,   mitResp↑, 1,   MKK7↓, 2,   Mortalin↓, 1,   mtDam?, 1,   mtDam↑, 40,   OCR↓, 13,   OCR↑, 7,   mt-OCR↑, 1,   OXPHOS↓, 6,   OXPHOS↑, 10,   mt-OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 4,   PDH↝, 1,   PDH∅, 1,   PGC-1α↑, 2,   PHB↓, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 4,   5-HETE↓, 1,   5LO↓, 3,   ACC↓, 4,   ACC↑, 3,   p‑ACC↑, 1,   ACLY↓, 3,   ACOX1↑, 1,   ACSL1↓, 1,   ACSL4↑, 6,   ALAT↓, 5,   ALAT↑, 1,   ALDOA↓, 2,   ALDOB↑, 1,   AMP↑, 3,   AMPK?, 1,   AMPK↓, 2,   AMPK↑, 42,   p‑AMPK↑, 6,   ATP↓, 47,   ATP↑, 3,   e-ATP↑, 1,   i-ATP↓, 1,   i-ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 5,   CAIX/CA9↑, 1,   CBS↑, 1,   CPT1A↓, 1,   CPT1A↑, 1,   DGAT1↓, 1,   ECAR↓, 8,   ECAR↑, 1,   ECAR↝, 1,   ENO1↓, 3,   ENO3↑, 1,   FABP4↓, 1,   FAO↓, 1,   FASN↓, 12,   FASN↑, 1,   FBI-1↓, 1,   FBP1↑, 1,   FBPase↑, 1,   FDG↓, 1,   G6PD↓, 2,   GALNT10↓, 1,   GLO-I↓, 1,   GLS↓, 3,   glucoNG↓, 1,   glucoNG↑, 1,   glucose↓, 6,   GlucoseCon↓, 34,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 3,   Glycolysis↓, 84,   Glycolysis↑, 1,   Glycolysis↝, 1,   GPI↓, 1,   GSK‐3β↓, 13,   GSK‐3β↑, 9,   p‑GSK‐3β↓, 7,   H2S↑, 1,   ac‑Histones↑, 1,   HK1↓, 2,   HK2↓, 39,   HK3↑, 1,   HMG-CoA↓, 6,   HSD17B4↓, 1,   IDH1↓, 1,   lactateProd↓, 40,   lactateProd↑, 1,   LDHA↓, 19,   LDHA∅, 1,   LDL↓, 4,   LDL↑, 1,   lipidLev↓, 2,   lipoGen↓, 2,   MCT4↓, 1,   NAD↓, 1,   NADPH↓, 6,   O-Glc↓, 1,   PCK1↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 15,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PFK↓, 10,   PFK1↓, 6,   PFK2↓, 1,   PFKFB3↓, 2,   PFKFB4?, 1,   PGC1A↑, 1,   PGK1↓, 2,   PGK2↑, 1,   PGM1↓, 1,   PGM1↑, 1,   PGM3↑, 1,   PIP3↑, 1,   PKLR↑, 1,   PKM1↑, 1,   PKM2↓, 37,   PKM2↑, 1,   PKM2∅, 2,   p‑PKM2↓, 1,   polyA↓, 1,   PPP↓, 3,   PYGL↓, 1,   Pyrim↓, 1,   R5P↝, 1,   p‑S6↓, 2,   SCD1↓, 4,   SCP2↓, 1,   SIRT1↓, 8,   SIRT1↑, 10,   SIRT2↓, 1,   SIRT2↑, 1,   SREBF2↓, 1,   SREBP1/SREBF1↓, 6,   SREBP2↓, 2,   TCA↓, 2,   TCA↑, 2,   TPI↓, 1,   TS↓, 3,   TumCM/A↓, 1,   UGDH↓, 2,   Warburg↓, 25,  

Cell Death(tgid=5) ⓘ

AIF↑, 12,   APAF1↑, 9,   Apoptosis?, 6,   Apoptosis↓, 20,   Apoptosis↑, 647,   mt-Apoptosis↑, 4,   ASC↑, 1,   BAD?, 1,   BAD↓, 3,   BAD↑, 19,   p‑BAD↓, 1,   Bak↑, 10,   BAX↓, 6,   BAX↑, 210,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 41,   Bcl-2↓, 223,   Bcl-2↑, 6,   Bcl-2↝, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 46,   Bcl-xL↑, 2,   BID↓, 1,   BID↑, 6,   BIM↑, 7,   BNIP3↑, 2,   BOK↑, 1,   Casp↓, 3,   Casp↑, 53,   Casp↝, 2,   cl‑Casp↑, 3,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 2,   Casp10∅, 1,   Casp12↑, 3,   Casp12↝, 1,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp2↑, 3,   Casp3↓, 7,   Casp3↑, 205,   Casp3↝, 2,   cl‑Casp3↓, 1,   cl‑Casp3↑, 84,   proCasp3↓, 1,   proCasp3↑, 3,   CASP4↑, 1,   Casp6↑, 1,   Casp7↓, 1,   Casp7↑, 27,   cl‑Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 44,   Casp8∅, 1,   cl‑Casp8↑, 9,   proCasp8↓, 1,   proCasp8↑, 3,   Casp9↑, 106,   p‑Casp9↑, 1,   cl‑Casp9↓, 1,   cl‑Casp9↑, 22,   proCasp9↓, 1,   proCasp9↑, 2,   cFLIP↓, 1,   Cupro↑, 1,   Cyt‑c↑, 104,   Cyt‑c↝, 3,   mt-Cyt‑c↓, 1,   Diablo↑, 5,   DIDO1/DIO-1↑, 1,   DR5↑, 21,   DR5∅, 1,   Endon↑, 4,   FADD↑, 8,   FADD∅, 1,   Fas↓, 2,   Fas↑, 21,   FasL↓, 1,   FasL↑, 7,   FasL⇅, 1,   Ferroptosis↓, 2,   Ferroptosis↑, 47,   GranB/GZMB↑, 1,   GRP58↓, 1,   GSDMD↑, 2,   cl‑GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 11,   IAP1↑, 1,   IAP2/BIRC3↓, 2,   ICAD↓, 1,   ICAD↑, 1,   ICD↑, 2,   iNOS↓, 16,   Mcl-1↓, 29,   MDM2↓, 15,   p‑MDM2↓, 1,   MLKL↑, 1,   MOMP↑, 2,   NAIP↓, 1,   Necroptosis↑, 8,   necrosis↑, 4,   NOXA↑, 4,   p38↓, 4,   p38↑, 26,   p‑p38↓, 4,   p‑p38↑, 8,   Paraptosis↑, 1,   Perforin↑, 1,   PUMA↓, 1,   PUMA↑, 7,   Pyro↑, 4,   RIP3↓, 1,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 72,   TNFR 1↓, 1,   TNFR 1↑, 2,   TRAIL↑, 3,   TRAIL⇅, 1,   TRAILR↑, 3,   TumCD?, 1,   TumCD↓, 2,   TumCD↑, 36,   TumCD∅, 2,   TUNEL↑, 2,   XIAP↓, 31,   YAP/TEAD↓, 12,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 239,   Akt↑, 9,   Akt↝, 1,   p‑Akt↓, 85,   p‑Akt↑, 2,   AKT1↓, 7,   Akt2↓, 3,   AKT3↓, 1,   AMPKα↓, 1,   AMPKα↑, 1,   BCAP↓, 1,   BRAF↓, 1,   CaMKII ↓, 3,   Cavin3↓, 1,   CIP2A↓, 2,   CK2↓, 3,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 2,   CREB2↓, 1,   cSrc↓, 3,   DDIT4↑, 1,   EGFR↓, 42,   p‑EGFR↓, 4,   ERK↓, 71,   ERK↑, 9,   ERK↝, 1,   p‑ERK↓, 28,   p‑ERK↑, 6,   FGFR1↓, 2,   FGFR2↓, 1,   FGFR4/CD334↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↓, 1,   IGF-1R↓, 10,   IGF-2R↑, 1,   IGFR↓, 4,   IKKα↓, 10,   IKKα↑, 3,   p‑IKKα↓, 2,   ILK↓, 1,   IR↓, 2,   IκB↓, 1,   JAK↓, 11,   JAK1↓, 9,   JAK1↑, 1,   JAK2↓, 23,   p‑JAK2↓, 2,   JNK↓, 6,   JNK↑, 30,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 7,   cl‑JNK↑, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 49,   MAPK↑, 23,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 4,   MARK4↓, 2,   MEK↓, 7,   p‑MEK↓, 3,   p‑MEK↑, 1,   MKK4↓, 1,   mTOR?, 1,   mTOR↓, 124,   mTOR↑, 6,   mTOR⇅, 1,   p‑mTOR↓, 20,   mTORC2↓, 1,   mTORC2↑, 1,   p42↑, 1,   p70S6↓, 2,   p70S6↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 7,   p‑P70S6K↓, 3,   p85S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PFKFB2↓, 1,   PHKG1↑, 1,   PI3K?, 1,   PI3K↓, 168,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 23,   PI3K/Akt↓, 6,   PI3k/Akt/mTOR↓, 1,   PI3K/mTOR/ETS2↓, 1,   PKA↓, 4,   PKCδ↓, 14,   PP2A↑, 1,   PRAS40↓, 1,   PRAS40↑, 1,   PRKCQ/PKCθ↓, 1,   PTEN↓, 3,   PTEN↑, 29,   Raf↓, 6,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 13,   RIP1↓, 2,   RIP1↑, 1,   S6K↓, 1,   p‑S6K↓, 1,   SGK1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 15,   Src↓, 3,   p‑Src↓, 2,   STAT↓, 8,   p‑STAT↓, 1,   STAT3↓, 94,   STAT3↑, 6,   STAT3↝, 1,   p‑STAT3↓, 23,   p‑STAT3↑, 2,   mt-STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 3,   STAT6↓, 2,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF2↓, 2,   ATF3↑, 2,   ATF4↑, 14,   p‑ATF4↝, 1,   BRD4↓, 1,   CBP↓, 2,   CBP↑, 1,   ChrMod↑, 1,   cJun↓, 5,   cJun↑, 2,   p‑cJun↓, 1,   p‑cJun↑, 2,   cMyc↓, 54,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 6,   DNMT1↑, 1,   DNMT3A↓, 1,   DNMT3B↓, 2,   DNMTs↓, 7,   EZH2↓, 3,   FOXM1↓, 5,   FOXO↑, 2,   FOXO1↓, 3,   FOXO1↑, 4,   FOXO3↓, 2,   FOXO3↑, 4,   p‑FOXO3↓, 1,   FOXO4↓, 2,   FOXO4↑, 1,   GATA2↑, 1,   GATA3↓, 1,   H3↓, 2,   H3↑, 1,   p‑H3↑, 1,   ac‑H3↑, 3,   ac‑H3↝, 1,   H3K18↓, 1,   H3K27ac∅, 1,   H3K9↓, 2,   H4↑, 2,   ac‑H4↑, 1,   ac‑H4∅, 1,   HATs↓, 4,   HATs↑, 1,   HDAC↓, 25,   HDAC1↓, 6,   HDAC2↓, 3,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 1,   HES1↓, 3,   HMTs↓, 1,   HOXB-AS1↓, 1,   IGF2BP3/IMP3/KOC↓, 1,   JPT1/HN1↓, 1,   KISS1↑, 1,   LINC01116↓, 1,   miR-106b↓, 2,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-122-5p↑, 1,   miR-124-3p↓, 1,   miR-130a↓, 3,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-143↑, 1,   miR-145↑, 1,   miR-148a↓, 1,   miR-149↑, 1,   miR-155↓, 3,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-19b↓, 2,   miR-205↑, 1,   miR-21↓, 12,   miR-21↝, 1,   miR-215-5p↑, 1,   miR-218↑, 1,   miR-22↑, 2,   miR-221↓, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-320a↓, 1,   miR-339-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 6,   miR-375↓, 1,   miR-375↑, 2,   miR-384↑, 1,   miR-422a↑, 2,   miR-486↑, 1,   miR-490↑, 1,   miR-590-3p↑, 1,   miR-592↑, 1,   miR-99↑, 1,   MTA2↓, 1,   Myc↓, 5,   Myc↑, 1,   MYCN↓, 1,   MYCN↑, 1,   n-MYC↓, 1,   NDRG1↑, 1,   NNMT↓, 1,   OCT4↓, 11,   OLIG2↓, 1,   other?, 1,   other↓, 5,   other↑, 12,   other↝, 38,   other∅, 1,   PAX2↓, 1,   PCAF↓, 1,   SD↑, 1,   SOX2↓, 10,   SOX4↓, 1,   SOX9↓, 1,   SUV39H↓, 5,   TBX15↑, 1,   TFAP2A↓, 1,   TFE3↑, 1,   TLE1↓, 1,   tumCV↓, 115,   tumCV↑, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 5,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 26,   p‑CHOP/DDIT3↝, 1,   CRT↑, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 8,   p‑eIF2α↑, 5,   p‑eIF2α↝, 1,   ER Stress↓, 1,   ER Stress↑, 53,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 15,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 3,   HSP27↑, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 5,   e-HSP70/HSPA5↓, 1,   HSP90↓, 21,   HSP90↑, 2,   HTRA↓, 1,   IRE1↓, 1,   IRE1↑, 3,   IRE1∅, 1,   p‑IRE1↑, 1,   NQO2↑, 1,   OTUB2↓, 1,   PDI↑, 2,   PERK↑, 13,   p‑PERK↝, 1,   Proteasome↓, 3,   SERPINH1/HSP47↓, 1,   UPR↓, 1,   UPR↑, 10,   mt-UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 2,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 3,   ATG5↓, 1,   ATG5↑, 10,   ATG7↑, 5,   autolysosome↑, 1,   Beclin-1/ATG6↓, 8,   Beclin-1/ATG6↑, 30,   CTSB↓, 2,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 7,   LC3B↓, 1,   LC3B↑, 3,   LC3B-II↓, 1,   LC3B-II↑, 7,   LC3I↓, 1,   LC3II↓, 2,   LC3II↑, 19,   LC3s↓, 1,   LC3s↑, 2,   lysoMP↑, 2,   MitoP↓, 1,   p62↓, 13,   p62↑, 7,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto?, 1,   TumAuto↓, 4,   TumAuto↑, 99,   TumAuto⇅, 1,   TumAuto↝, 2,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,   p‑ULK1/ATG1↑, 1,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   ATM↓, 1,   ATM↑, 4,   p‑ATM↑, 1,   ATR↑, 4,   BRCA1↓, 3,   BRCA2↓, 1,   DNAdam↓, 5,   DNAdam↑, 95,   DNArepair↓, 5,   DNArepair↑, 3,   ERCC1↓, 2,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   m-FAM72A↓, 1,   FEN1↓, 2,   hTERT/TERT↓, 13,   Ku70/XRCC6↓, 1,   NHEJ↓, 1,   NKX3.1↑, 1,   P53?, 2,   P53↓, 6,   P53↑, 128,   P53⇅, 1,   P53↝, 4,   p‑P53↓, 1,   p‑P53↑, 6,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 24,   PARP↝, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 111,   PARP1↑, 4,   cl‑PARP1↑, 3,   PCNA↓, 44,   PCNA↑, 1,   PCNA↝, 1,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 2,   SIRT6↑, 1,   SMG1↑, 1,   Telomerase↓, 13,   TOP1↓, 6,   TOP2↓, 6,   TOP2↑, 1,   TP53↓, 1,   TP53↑, 3,   TRF2↓, 2,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 17,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 2,   CDK1↓, 27,   CDK1↑, 5,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 53,   CDK2↑, 6,   CDK4↓, 61,   CDK4↑, 3,   CDK4∅, 1,   CDK4/6↓, 1,   CDK6↓, 19,   CDK6↑, 3,   CDK6∅, 1,   CDK7↓, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN2C/p18↑, 1,   CHK1↓, 3,   CHK1↑, 4,   CHK1↝, 1,   p‑CHK1↓, 1,   p‑CHK1↑, 1,   Chk2↓, 3,   Chk2↑, 4,   p‑Chk2↑, 1,   Cyc↓, 4,   cycA1/CCNA1↓, 16,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 40,   CycB/CCNB1↑, 6,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 144,   cycD1/CCND1↑, 4,   cycD1/CCND1↝, 1,   cycD1/CCND1∅, 1,   CycD3↓, 4,   cycE/CCNE↓, 33,   cycE/CCNE↑, 3,   cycE/CCNE↝, 1,   cycE1↓, 1,   E2F4↑, 1,   E2Fs↓, 7,   E2Fs↑, 1,   FBXO5/EMI1↓, 1,   GADD34↑, 1,   GADD45A↓, 1,   GADD45A↑, 5,   Ki-67↓, 65,   MAD↓, 1,   mitA↑, 4,   MKI67↑, 1,   p19↑, 1,   P21↓, 5,   P21↑, 113,   P21↝, 1,   p‑P21↑, 1,   p27/CDKN1B↓, 5,   p27/CDKN1B↑, 35,   cl‑p27/CDKN1B↓, 1,   PLK1↓, 1,   pRB↓, 4,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 2,   RRM2↓, 1,   TAp63α↑, 1,   TumCCA?, 3,   TumCCA↓, 13,   TumCCA↑, 418,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 4,   ALDH1A3↓, 1,   AXIN1↓, 1,   AXIN1↑, 3,   BMI1↓, 2,   BMP7/OP1↓, 2,   CD133↓, 15,   CD24↓, 6,   CD34↓, 2,   cFos↓, 7,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 62,   CSCs↑, 3,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 11,   EIF4E↓, 1,   EP2↓, 1,   EP4/PTGER4↓, 2,   FGF↓, 3,   GH↓, 1,   Gli1↓, 14,   HH?, 1,   HH↓, 22,   HMGCR↓, 2,   IGF-1↓, 10,   IGF-1↑, 1,   IGF-2↓, 1,   IGF-2↑, 1,   IGFBP1↑, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 2,   Ki-67↓, 65,   Let-7↑, 3,   LRP6↓, 2,   MCM2↓, 1,   mTORC1↓, 4,   Nanog↓, 11,   Nestin↓, 1,   NICD↓, 1,   NKD2↑, 2,   NOTCH↓, 14,   NOTCH↑, 2,   NOTCH1↓, 11,   NOTCH1↑, 1,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH3↓, 3,   OGF↑, 1,   OGFr↑, 4,   p300↓, 3,   PCLAF↓, 1,   Piezo1↑, 1,   circ‑PLEKHM3↑, 1,   PTCH1↓, 2,   SCF↓, 1,   Shh↓, 10,   Smo↓, 6,   Smo∅, 1,   TAZ↓, 2,   TumCG?, 3,   TumCG↓, 213,   TumCG↑, 7,   TumCG↝, 1,   TumCG∅, 1,   TumCP?, 6,   TumCP↓, 1259,   TumCP↑, 26,   TumCP⇅, 6,   TumCP∅, 5,   p‑TumCP↓, 1,   tyrosinase↓, 2,   WDR72↓, 1,   Wnt↓, 57,   Wnt/(β-catenin)↓, 9,   ZFX↓, 2,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AGRN↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↑, 1,   AP-1↓, 12,   AP-1↝, 1,   ASAP2↓, 1,   ATPase↓, 2,   AXL↓, 2,   BACH1↓, 1,   BACH1↑, 1,   Ca+2?, 1,   Ca+2↓, 3,   Ca+2↑, 36,   Ca+2↝, 2,   i-Ca+2↑, 3,   CAFs/TAFs↓, 1,   cal2↑, 2,   CCAT1↓, 2,   CCN2/CTGF↓, 3,   CD11b↑, 1,   CD38↓, 1,   CD38↑, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Chl↑, 1,   Cofilin↓, 2,   COL1A1↓, 1,   COL3A1↓, 1,   COL4A3↓, 1,   E-cadherin↓, 10,   E-cadherin↑, 62,   E-cadherin↝, 1,   EMT?, 1,   EMT↓, 117,   EMT↑, 2,   EpCAM↓, 2,   F-actin↓, 3,   FAK↓, 13,   FAK↑, 2,   p‑FAK↓, 5,   Fibronectin↓, 5,   Furin↓, 1,   GLI2↓, 4,   GLI3↑, 1,   IQGAP3↓, 1,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB4↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   LAMs↓, 2,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 2,   MET↓, 2,   MET↑, 1,   MMP-10↓, 2,   MMP1↓, 4,   MMP13↓, 4,   MMP14↓, 1,   MMP16↓, 2,   MMP17↓, 1,   MMP2↓, 102,   proMMP2↓, 1,   MMP3↓, 8,   MMP7↓, 7,   MMP9↓, 139,   MMP9↑, 2,   MMPs↓, 31,   MMPs↝, 1,   MTA1↓, 1,   MUC1↓, 1,   MUC4↓, 1,   N-cadherin↓, 42,   N-cadherin↑, 1,   N-cadherin↝, 1,   NCAM↓, 1,   NEDD9↓, 1,   p44↓, 1,   p44↑, 1,   p‑p44↓, 1,   PAK1↓, 3,   pax↓, 2,   PCBP1↓, 1,   PDGF↓, 6,   Rac1↓, 2,   RHBDD1↓, 1,   Rho↓, 5,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 16,   Smad1↓, 1,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 2,   p‑SMAD2↓, 5,   SMAD3↓, 5,   SMAD3↑, 1,   p‑SMAD3↓, 3,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 32,   Snail↑, 1,   SPARC↑, 2,   STAC2↓, 1,   talin?, 1,   talin↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 21,   TGF-β↑, 2,   TGF-β↝, 1,   TGF-β1↓, 3,   THBS1↓, 1,   TIMP1↓, 2,   TIMP1↑, 14,   TIMP2↓, 1,   TIMP2↑, 11,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 2,   TumCA↓, 6,   TumCA↑, 1,   TumCI↓, 258,   TumCI↑, 4,   TumCMig?, 1,   TumCMig↓, 293,   TumCMig↑, 6,   TumMeta↓, 139,   TumMeta↑, 9,   TumPF↓, 1,   Twist↓, 16,   Twist↑, 1,   TXNIP↑, 3,   uPA↓, 16,   uPAR↓, 3,   UroPA↓, 1,   Vim?, 1,   Vim↓, 52,   Vim↑, 2,   vinculin↓, 1,   Zeb1↓, 7,   ZEB2↓, 2,   ZEB2↑, 1,   α-SMA↓, 4,   α-SMA↑, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 77,   β-catenin/ZEB1↑, 2,   p‑β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 162,   angioG↑, 5,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 4,   EGR1↓, 1,   EGR1↑, 1,   EGR4↓, 1,   Endoglin↑, 2,   eNOS↓, 3,   HIF-1↓, 6,   Hif1a↓, 84,   Hif1a↑, 2,   Hif1a↝, 1,   Hypoxia↓, 2,   LOX1↓, 1,   NO↓, 7,   NO↑, 5,   PGI2↓, 1,   TYMP/ECGF1↓, 1,   VCAM-1↓, 4,   VEGF↓, 120,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 5,   VEGFR2/KDR/Flk1↓, 15,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   AQPs↓, 2,   BBB↑, 6,   BBB∅, 1,   CellMemb↑, 3,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN2↓, 2,   EPR↑, 9,   GLUT1↓, 25,   GLUT1↑, 2,   GLUT1∅, 1,   GLUT2↓, 3,   GLUT3↓, 2,   GLUT3↑, 1,   GLUT3∅, 1,   GLUT4↓, 1,   IBI↑, 1,   KCNH2/hERG↓, 1,   MMP↓, 173,   MMP↑, 4,   MMP↝, 2,   MMP∅, 1,   MPT↓, 1,   MPT↑, 4,   NHE1↓, 1,   OATPs↓, 1,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2↓, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPM7↑, 1,   TRPV1↑, 3,   TRPV1↝, 1,   VGCC↑, 2,   VGSC↑, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   B2M↓, 1,   CB2 / CNR2↓, 1,   CB2 / CNR2↑, 3,   CD155↓, 2,   CD4+↓, 1,   CD4+↑, 5,   CD44↓, 19,   CD44↝, 1,   CD47↓, 1,   CD8+↑, 11,   cDC2↓, 1,   p‑cDC2↓, 1,   COX1↓, 3,   COX1↑, 1,   COX2/PTGS2↓, 85,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCL6/GCP-2↓, 1,   CXCL9↓, 1,   CXCR2↓, 2,   CXCR4↓, 14,   DCells↑, 1,   DR4↑, 11,   DR4∅, 1,   Eos↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   Gal-3↓, 3,   Gal1↑, 1,   HMGB1↓, 5,   HMGB1↑, 1,   ICAM-1↓, 9,   IFN-γ↓, 3,   IFN-γ↑, 3,   Igs↑, 2,   IL1↓, 3,   IL1↑, 2,   IL10↓, 2,   IL10↑, 2,   IL12↑, 3,   IL17↓, 1,   IL18↓, 2,   IL1α↓, 1,   IL1β↓, 22,   IL1β↑, 2,   IL2↓, 1,   IL2↑, 2,   IL4↓, 2,   IL4↑, 2,   IL5↓, 1,   IL6↓, 49,   IL6↑, 2,   IL8↓, 12,   IL8↑, 1,   Imm↑, 25,   Imm↝, 2,   Inflam↓, 65,   IRAK1↓, 1,   IRAK4↓, 1,   LIF↑, 1,   LRIG1↑, 1,   LTA/TNF-β↓, 1,   LTA/TNF-β↑, 1,   pol-M1↑, 2,   M2 MC↓, 4,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↑, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 204,   NF-kB↑, 7,   NF-kB↝, 2,   p‑NF-kB↓, 3,   p‑NF-kB↑, 2,   NFKBIZ/IκBζ↓, 1,   NK cell↑, 7,   NLRP3↓, 6,   NLRP3↑, 3,   NOD1↓, 1,   p50↓, 1,   p65↓, 9,   p65↑, 1,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 10,   PD-L1↑, 3,   PGE2↓, 13,   PSA↓, 17,   SOCS-3↑, 1,   T-Cell↑, 4,   TCF↓, 5,   Th1 response↑, 2,   TIGIT↓, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↓, 6,   TLR4↑, 2,   TNF-α↓, 42,   TNF-α↑, 8,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3,   TRADD↑, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 2,   pH↑, 1,   e-pH↑, 2,   i-pH↓, 1,   TAMS↓, 2,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   CAXII/CA12↑, 1,   ChE↓, 1,   PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 2,   ADRB2↓, 1,   AhR↓, 1,   AhR↑, 2,   AR↓, 24,   AR-V7?, 1,   COMT↓, 1,   CYP19?, 1,   CYP19↓, 2,   DHT↓, 1,   ER-α36↓, 3,   ER-α36↝, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   FGF21↓, 1,   NR1H4↑, 1,   NR3C2/MR↑, 2,   PPARα↓, 1,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 9,   PRL↓, 1,   RANKL↓, 2,   SRC3↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   AKR1B10↓, 1,   BioAv↓, 49,   BioAv↑, 50,   BioAv↝, 16,   BioEnh?, 1,   BioEnh↑, 1,   chemoR↓, 2,   ChemoSen?, 1,   ChemoSen↓, 4,   ChemoSen↑, 235,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 1,   CompStab↓, 2,   CompStab↑, 4,   CYP1A1↓, 3,   CYP1A1↑, 4,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP1B1↓, 2,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 4,   Dose?, 11,   Dose↓, 3,   Dose↑, 7,   Dose⇅, 3,   Dose↝, 108,   Dose∅, 9,   DrugR↓, 2,   eff?, 1,   eff↓, 104,   eff↑, 145,   eff⇅, 3,   eff↝, 14,   eff∅, 4,   GSTA1↓, 1,   GSTA1↑, 1,   GSTP1/GSTπ↑, 1,   GSTZ1↓, 1,   Half-Life↓, 12,   Half-Life↑, 4,   Half-Life↝, 11,   Half-Life∅, 1,   MDR1↓, 11,   MRP↓, 1,   MRP1/ABCC1↓, 5,   MRP2↓, 1,   MRP5↓, 1,   P-gp/ABCB1↓, 20,   P-gp/ABCB1↑, 1,   P450↓, 3,   RadioS?, 1,   RadioS↑, 63,   RadioS↝, 1,   selectivity?, 1,   selectivity↑, 150,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 98,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   ALAT↓, 5,   ALAT↑, 1,   ALB↑, 1,   ALP↓, 3,   ALP↑, 1,   AR↓, 24,   AST↓, 4,   AST↑, 1,   B2M↓, 1,   BloodF↓, 1,   BMD↑, 2,   BRAF↓, 1,   BRCA1↓, 3,   BUN↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 42,   p‑EGFR↓, 4,   ERα/ESR1↓, 1,   EZH2↓, 3,   Ferritin↓, 1,   Ferritin↑, 1,   FOXM1↓, 5,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 13,   IL6↓, 49,   IL6↑, 2,   KRAS↓, 1,   LDH↓, 12,   LDH↑, 4,   LDH↝, 2,   e-LDH↑, 1,   Maspin↑, 1,   Myc↓, 5,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 10,   PD-L1↑, 3,   Polyps↓, 2,   PSA↓, 17,   TP53↓, 1,   TP53↑, 3,   TRIB3↑, 1,   Tumccf↓, 9,   Tumccf↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 87,   AntiCan∅, 1,   antiD↑, 1,   antiNeop↑, 6,   AntiTum↓, 2,   AntiTum↑, 37,   cachexia↓, 3,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP?, 1,   chemoP↑, 48,   chemoPv↑, 32,   ChemoSideEff↓, 5,   ChemoSideEff∅, 1,   fatigue↓, 1,   FTO↓, 1,   FTO↑, 2,   hepatoP↓, 1,   hepatoP↑, 9,   kidSt↓, 1,   neuroP↓, 1,   neuroP↑, 11,   NP/CIPN↓, 3,   OS↑, 30,   OS∅, 1,   Pain↓, 3,   PFS↑, 1,   PFS∅, 1,   Pin1↓, 2,   QoL↑, 11,   QoL∅, 1,   radioP↑, 15,   Remission↑, 2,   RenoP↑, 8,   Risk↓, 39,   Risk↑, 1,   Strength↑, 1,   TGFβR1↓, 1,   toxicity?, 1,   toxicity↓, 42,   toxicity↑, 6,   toxicity⇅, 1,   toxicity↝, 14,   toxicity∅, 3,   TumNum?, 1,   TumNum↓, 2,   TumVol?, 1,   TumVol↓, 58,   TumVol↑, 1,   TumVol∅, 1,   TumW↓, 30,   TumW∅, 1,   Weight↑, 1,   Weight∅, 4,   Wound Healing↓, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiP↑, 2,   Bacteria↓, 2,   GutMicro↑, 11,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 4,   Ingr↑, 1,   Ingr↝, 18,  
Total Targets: 1504

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 8,   antiOx↑, 101,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↑, 33,   Fenton↓, 1,   GPx↑, 26,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 2,   GSH↑, 31,   GSR↑, 7,   GSTs↑, 8,   H2O2↓, 3,   HDL↓, 1,   HDL↑, 4,   HO-1?, 1,   HO-1↓, 2,   HO-1↑, 21,   hyperG↓, 1,   hyperG↝, 1,   Keap1↓, 4,   Keap1↝, 1,   lipid-P↓, 26,   MDA↓, 20,   MDA↑, 1,   MPO↓, 4,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 4,   NRF2↓, 2,   NRF2↑, 40,   RNS↓, 5,   ROS?, 3,   ROS↓, 83,   ROS↑, 7,   ROS⇅, 1,   ROS∅, 1,   mt-ROS?, 1,   selenoP↑, 1,   SOD↑, 36,   SOD1↑, 6,   SOD2↑, 3,   TAC↑, 4,   TBARS↓, 2,   VitC↑, 2,   VitE↓, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,   IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 2,   mtDam↓, 1,   OCR↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   ACSL4↓, 1,   ALAT↓, 9,   AMPK↑, 6,   ATP↓, 1,   ATP↑, 6,   CRM↑, 1,   ECAR↓, 1,   ECAR∅, 1,   glucose↓, 6,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 4,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 2,   HK2↑, 1,   HMG-CoA↓, 1,   LDHA↑, 1,   LDL↓, 7,   lipidLev↓, 2,   NADPH↓, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   Apoptosis↓, 5,   ASC↓, 1,   BAX↓, 3,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-2↑, 3,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 8,   Casp3↑, 2,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   Fas↓, 2,   FasL↓, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 11,   iNOS↑, 2,   necrosis↓, 1,   p38↓, 3,   p‑p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 6,   Akt↝, 1,   p‑Akt↑, 2,   ERK↓, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IκB?, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 2,   JNK↑, 2,   p‑JNK↓, 4,   MAPK↓, 7,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 3,   mTOR↑, 2,   PDGFR-BB↓, 1,   PI3K↓, 2,   PI3K↑, 5,   PKCδ↓, 1,   PKCδ↑, 1,   RIP1↓, 1,   STAT↓, 1,   STAT3↓, 2,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF2↑, 1,   ATF4↓, 1,   cMyc↓, 1,   FOXO3↑, 1,   HDAC↓, 1,   HOTAIR↑, 1,   other?, 1,   other↓, 4,   other↑, 3,   other↝, 8,   PhotoS↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 2,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 2,   P53↑, 1,   PARP↑, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   P21↑, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   Diff↑, 1,   Diff↝, 1,   EP2↓, 1,   FGF↑, 1,   HH↓, 1,   neuroG↑, 2,   NOTCH↓, 1,   TumCP↓, 10,   TumCP↑, 1,   Wnt↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   EMT↑, 1,   FAK↑, 1,   LAMs↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP9↓, 2,   Smad1↑, 1,   TGF-β↓, 2,   TGF-β↑, 3,   TumCI↓, 2,   TumCMig↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 1,   E-sel↓, 1,   Hif1a↓, 1,   NO↓, 11,   VCAM-1↓, 4,   VEGF↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 6,   BBB↝, 1,   GastroP↑, 3,   GLUT1↓, 1,   GLUT2↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 3,   MMP↑, 4,   MMP∅, 1,   SVCT-2↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   COX1↓, 4,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 4,   IFN-γ↓, 6,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 2,   IL10↑, 3,   IL12↓, 2,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 22,   IL2↓, 1,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6?, 1,   IL6↓, 22,   IL6↑, 1,   IL8↓, 4,   Imm↑, 11,   Imm⇅, 1,   Imm↝, 1,   Inflam?, 1,   Inflam↓, 106,   Inflam↑, 1,   IRF3↓, 2,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MCP1/CCL2↑, 1,   MyD88↓, 2,   NF-kB?, 1,   NF-kB↓, 28,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 6,   NLRP3↑, 2,   p65↓, 1,   PGE2↓, 6,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 2,   TLR4↓, 6,   TLR4↑, 1,   TLR4∅, 1,   TNF-α?, 1,   TNF-α↓, 29,   TNF-α↑, 1,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 2,   Ach↑, 1,   AChE↓, 12,   AChE↑, 1,   BChE↓, 3,   BDNF↑, 7,   proBDNF↑, 1,   ChAT↑, 1,   GABA↑, 2,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 4,   TPH1↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 1,   Aβ↓, 10,   BACE/β-secretase↓, 3,   tau↓, 1,   p‑tau↓, 3,   XO↓, 1,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   Estro↓, 1,   PPARγ↑, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 37,   BioAv↑, 49,   BioAv↝, 21,   BioEnh↑, 2,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 15,   eff↓, 1,   eff↑, 9,   eff↝, 2,   GSTA1↑, 2,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↑, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9,   ALP↓, 2,   AST↓, 10,   BG↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 7,   creat↓, 2,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 22,   IL6↑, 1,   IRes↝, 1,   LDH↓, 4,   NOS2↓, 2,   RAGE↓, 1,   SpO2↑, 1,   TC↓, 2,   TG/TAG↓, 2,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 7,   antiAll↑, 13,   AntiArt↑, 6,   AntiCan↓, 2,   AntiCan↑, 21,   antiCG↑, 2,   antiD↑, 1,   AntiDiabetic↓, 3,   AntiDiabetic↑, 22,   antiPs↑, 2,   AntiTum↑, 9,   ANXi↓, 1,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↑, 34,   CardioT↓, 1,   chemoP↑, 8,   chemoPv↑, 5,   cognitive↓, 1,   cognitive↑, 16,   diuretic↑, 2,   hepatoP↓, 2,   hepatoP↑, 37,   Learn↑, 1,   memory↑, 14,   Mood↑, 1,   motorD↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 59,   Obesity↓, 15,   OS↑, 1,   Pain↓, 1,   QoL↓, 1,   radioP↑, 3,   RenoP↓, 1,   RenoP↑, 14,   Risk↓, 2,   Sleep↑, 2,   Stress↓, 2,   Stroke↓, 11,   toxicity↓, 48,   toxicity↑, 3,   toxicity↝, 9,   toxicity∅, 12,   Weight↑, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 11,   AntiFungal↑, 4,   AntiP↓, 1,   AntiP↑, 3,   AntiViral↑, 13,   Bacteria↓, 21,   GutMicro↑, 16,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   CA↑, 1,   Catechins↑, 1,   FA↑, 1,   Fibre↑, 1,   GA↑, 1,   Ingr↑, 2,   Ingr↝, 7,   LT↑, 1,   Myr↑, 1,   Phen↑, 1,   Poly↑, 1,   QC↑, 2,  
Total Targets: 448

Scientific Paper Hit Count for: TumCP, Tumor Cell proliferation
44 Curcumin
25 Quercetin
24 Luteolin
24 Thymoquinone
23 Magnetic Fields
23 Shikonin
19 EGCG (Epigallocatechin Gallate)
19 Sulforaphane (mainly Broccoli)
18 Berberine
18 Resveratrol
18 Matrine
17 Phenethyl isothiocyanate
17 Kaempferol
17 Licochalcone A
16 Silver-NanoParticles
16 Radiotherapy/Radiation
16 Baicalein
14 Cisplatin
14 Apigenin (mainly Parsley)
14 Melatonin
14 Capsaicin
14 phytic acid, Inositol hexakisphosphate
13 Propolis -bee glue
13 Formononetin
13 Honokiol
13 Magnolol
12 Artemisinin
12 Fisetin
12 Garcinol
12 Lycopene
11 Ashwagandha(Withaferin A)
11 Astaxanthin
11 Boron
11 Metformin
11 Crocetin
11 Emodin
11 Isorhamnetin
11 Juglone
11 Nimbolide
10 Chrysin
10 itraconazole
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
10 Urolithin
9 Berbamine
9 Flaxseed/Linseed
9 Gallic acid
9 Hyperoside
9 Ivermectin
8 Citric Acid
8 5-fluorouracil
8 chitosan
8 Beta-Caryophyllene
8 chaetocin
8 Dandelion Root
8 HydroxyTyrosol
8 Isobavachalcone
8 Isoliquiritigenin
8 Licorice
7 Astragalus
7 Benzyl isothiocyanate
7 Anethole/trans-Anethole
7 Paclitaxel/Taxol
7 Bufalin/Huachansu
7 Centella asiatica / Gotu kola → asiaticoside
7 Eugenol
7 Evodiamine
7 Ferulic acid
7 Gambogic Acid
7 Ginkgetin
7 isoorientin
7 Linalool
7 mebendazole
7 Mangiferin
7 Piperlongumine
6 Boswellia (frankincense)
6 Chemotherapy
6 Carnosic acid
6 Rosmarinic acid
6 Celastrol
6 Carvone
6 Cucurbitacin
6 Diclofenac
6 Diindolylmethane
6 Ellagic acid
6 isoquercitrin
6 Lemongrass Extract/Citral
6 Morin
6 Mushroom Lion’s Mane, Hericium erinaceus
6 Phenylbutyrate
6 salinomycin
6 Zyflamend
5 Allyl isothiocyanate
5 DTS(dibenzyl trisulphide) from Anamu
5 Gemcitabine (Gemzar)
5 Betulinic acid
5 Carvacrol
5 Cinnamon
5 Copper and Cu NanoParticles
5 Deguelin
5 Indole-3-carbinol
5 D-limonene
5 Fucoidan
5 Galloflavin
5 Geraniol
5 Hydrogen Gas
5 Helleborus niger extracts – Christmas Rose
5 low dose naltrexone
5 Magnetic Field Rotating
5 Patchouli Oil (Pogostemon cablin)
5 Vitamin K2
4 Allicin (mainly Garlic)
4 Atorvastatin
4 brusatol
4 Celecoxib
4 Chlorogenic acid
4 Chlorophyllin
4 Photodynamic Therapy
4 Date Fruit Extract
4 Disulfiram
4 Genistein (soy isoflavone)
4 Fenbendazole
4 Ginger/6-Shogaol/Gingerol
4 iodine
4 Inositol
4 Lutein
4 Marjoram (Origanum majorana)
4 Phycocyanin
4 Piperine
4 Ursolic acid
3 1,8-Cineole
3 Alpha-Lipoic-Acid
3 Andrographis
3 Isovitexin
3 Aspirin
3 immunotherapy
3 Docetaxel
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Caffeic acid
3 Thymol-Thymus vulgaris
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Cyclopamine
3 Cynaropicrin
3 Dichloroacetate
3 diet Methionine-Restricted Diet
3 Ginkgo biloba-EGb 761
3 Ginkgo biloba
3 Ginkgolide B
3 Vitamin C (Ascorbic Acid)
3 Lactoferrin/Talactoferrin
3 Methylene blue
3 Moringa oleifera
3 Mushroom Chaga, Inonotus obliquus
3 Oleuropein
3 Propyl gallate
3 Plumbagin
3 Pterostilbene
3 Selenium
3 Sesamin
3 Terpinen-4-ol / Tea Tree Oil
3 Aflavin-3,3′-digallate
3 VitK3,menadione
3 Walnut
3 Zerumbone
2 Sorafenib (brand name Nexavar)
2 3-bromopyruvate
2 Auranofin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Ascorbyl Palmitate
2 Arctigenin
2 Baicalin
2 Biochanin A
2 Isothiocyanates
2 Brucea javanica
2 Bacopa monnieri
2 Beetroot
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Hydroxycinnamic-acid
2 Coenzyme Q10
2 Carica papaya leaf extract
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Dichloroacetophenone(2,2-)
2 diet FMD Fasting Mimicking Diet
2 diet Short Term Fasting
2 Echinacea
2 Eurycomanone
2 Flaxseed Oil
2 Arsenic trioxide
2 Ginkgolic acids
2 γ-linolenic acid (Borage Oil)
2 Graviola
2 Grapeseed extract
2 hydrogen sulfide
2 doxorubicin
2 Laetrile B17 Amygdalin
2 lambertianic acid
2 Lapachol
2 SDG/lignans
2 Mung Bean Sprouts
2 Modified Citrus Pectin
2 Lemon Balm/Melissa officinalis
2 Methylsulfonylmethane
2 Mistletoe/Viscum album Extracts
2 Naringin
2 Niclosamide (Niclocide)
2 Psoralidin
2 EMF
2 Rutin
2 α-Santalol/Sandalwood oil
2 Sulfasalazine
2 Salvia miltiorrhiza
2 Vitamin D3
1 2-DeoxyGlucose
1 Açaí, Euterpe oleracea
1 Glucose
1 SonoDynamic Therapy UltraSound
1 Zinc
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Fennel Oil/Foeniculum vulgare
1 Aloe anthraquinones
1 beta-glucans
1 almonertinib
1 bempedoic acid
1 Bevacizumab (brand Avastin)
1 temozolomide
1 Bromelain
1 borneol
1 Bortezomib
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 Bullatacin
1 hydroxychloroquine
1 Cat’s Claw
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Cannabidiol
1 Camu camu
1 Camptothecin
1 irinotecan
1 Cranberry
1 CUSP9
1 Dasatinib/Phyrago
1 Dihydrocaffeic Acid
1 Electrical Pulses
1 Exercise
1 Vitamin E
1 ferumoxytol
1 Trastuzumab
1 tamoxifen
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Ginseng
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 HydroxyCitric Acid
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 Hyperthermia
1 Inoscavin A
1 Recombinant Methioninase
1 L-Theanine
1 Lactobacillus
1 MCT, metronomic chemo
1 Methyl Jasmonate
1 methylseleninic acid
1 Caffeine
1 Magnesium
1 Methylglyoxal
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 magnetic nanoparticles
1 Mucuna pruriens/Velvet Bean
1 Mushroom Maitake
1 nicotinamide adenine dinucleotide
1 Bicarbonate(Sodium)
1 Oroxylin-A
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 Purple Corn / Purple Maize
1 xanthohumol
1 Pomi-T
1 Propranolol
1 Gold NanoParticles
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Oxaliplatin
1 Selenium NanoParticles
1 Lignans
1 diet Plant based
1 Spirulina(Arthrospira/Limnospira)
1 Spermidine
1 tetrathiomolybdate
1 Tumor Treating Fields
1 Turmerones
1 Usnic acid
1 Vitexin
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:327  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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