eff Cancer Research Results

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1456- SFN,    Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
tumCV↓, TumCP↓, cl‑PARP↑, cl‑Casp3↑, TumCCA↑, ROS↑, MMP↓, γH2AX↑, eff↓, *toxicity↓,
1455- SFN,    Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress
- in-vitro, Cerv, HeLa - in-vitro, Nor, 1321N1
*ROS↓, *BioAv↑, LC3II↑, LAMP1?, TumAuto↑, TFEB↑, ROS↑, eff↓,
1454- SFN,    Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract
- Human, Nor, NA
*HDAC↓, *eff↑, *eff↑, *eff↑, *BioAv↑, *BioAv↑,
1437- SFN,    Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition
- Review, Var, NA
HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, HDAC8↓, eff↑, ac‑HSP90↑, DNMT1↓, DNMT3A↓, hTERT/TERT↓, NRF2↑, HO-1↑, NQO1↑, miR-155↓, miR-200c↑, SOX9↓, *toxicity↓,
1474- SFN,    Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway
- in-vitro, Colon, SW480
TumCG↓, Apoptosis↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp7↑, Casp9↑, ROS↑, e-ERK↑, p38↑, P53∅, eff↓, ChemoSen↑,
1509- SFN,    Combination therapy in combating cancer
- Review, Var, NA
NRF2↑, ChemoSideEff↓, eff↑, TumCP↓, Apoptosis↑, TumCCA↑, ChemoSen↑, PSA↓, P53↑, Hif1a↓, CAIX/CA9↓, chemoR↓, 5HT↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, Synergy↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
1501- SFN,    The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation
- in-vitro, CRC, T24/HTB-9
Dose↝, NRF2↑, GSH↓, eff↑,
1496- SFN,  VitD3,    Association between histone deacetylase activity and vitamin D-dependent gene expressions in relation to sulforaphane in human colorectal cancer cells
- in-vitro, CRC, Caco-2
eff↑, VDR↑, CYP11A1↓, HDAC↓,
1495- SFN,  doxoR,    Sulforaphane protection against the development of doxorubicin-induced chronic heart failure is associated with Nrf2 Upregulation
- in-vivo, Nor, NA
*CardioT↓, *NRF2↑, *eff↓, *ROS↓,
1484- SFN,    Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action
- Review, Var, NA - Review, AD, NA
neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,
1483- SFN,    Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment
- in-vitro, OS, 143B - in-vitro, Nor, HEK293 - in-vivo, OS, NA
AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,
1482- SFN,    Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway
- in-vitro, Bladder, T24/HTB-9
tumCV↓, Apoptosis↑, Cyt‑c↑, Bax:Bcl2↑, Casp9↑, Casp3↑, Casp8∅, cl‑PARP↑, ROS↑, MMP↓, eff↓, ER Stress↑, p‑NRF2↑, HO-1↑,
1480- SFN,    Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells
- in-vitro, CRC, HCT116
tumCV↓, TumCCA↑, Apoptosis↑, cycA1/CCNA1↑, CycB/CCNB1↑, CDC25↓, CDK1↓, ROS↑, eff↓, Cyt‑c↑, AIF↑, ER Stress↑,
1476- SFN,  PDT,    Enhancement of cytotoxic effect on human head and neck cancer cells by combination of photodynamic therapy and sulforaphane
- in-vitro, HNSCC, NA
Synergy↑, tumCV↓, ROS↑, eff↓, Casp↑,
1731- SFN,    Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts
- Review, Var, NA
CSCs↓, ChemoSen↑, NF-kB↓, Shh↓, Smo↓, Gli1↓, GLI2↓, PI3K↓, Wnt↓, β-catenin/ZEB1↓, Nanog↓, COX2/PTGS2↓, Zeb1↓, Snail↓, ChemoSideEff↓, eff↑, *BioAv↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
1727- SFN,    Glucoraphanin, sulforaphane and myrosinase activity in germinating broccoli sprouts as affected by growth temperature and plant organs
- Analysis, Nor, NA
eff↑, eff↓,
1728- SFN,    Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
- Review, Nor, NA
eff↑, eff↓,
1729- SFN,    Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
- Review, Nor, NA
eff↑, angioG↓, VEGF↓, MMP9↓, MMP2↓,
3298- SIL,    Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells
- in-vitro, BC, MCF7
LC3II↑, Beclin-1/ATG6↑, Bcl-2↓, ROS↑, MMP↓, ATP↓, eff↓, BNIP3?, TumAuto↑, eff↑,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, Synergy↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3292- SIL,  Fe,    Anti-tumor activity of silymarin nanoliposomes in combination with iron: In vitro and in vivo study
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1
*antiOx↑, ROS↑, OS↑, Weight↑, TumVol↓, eff↑, Fenton↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
2358- SK,    SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2
- in-vivo, Park, NA
*eff↑, *PKM2↓, *motorD↑, *lactateProd↓,
2364- SK,    Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation
- in-vivo, PSA, NA
eff↑, lactateProd↓, PKM2↓,
2230- SK,    Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,
2213- SK,    Shikonin attenuates cerebral ischemia/reperfusion injury via inhibiting NOD2/RIP2/NF-κB-mediated microglia polarization and neuroinflammation
- in-vivo, Stroke, NA
*neuroP↑, *Inflam↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *ARG1/2↑, *TGF-β↑, *IL10↑, *NF-kB↓, *eff↓,
2201- SK,    Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice
- in-vitro, PSA, HaCaT - in-vivo, NA, NA
*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,
2196- SK,    Research progress in mechanism of anticancer action of shikonin targeting reactive oxygen species
- Review, Var, NA
*ALAT↓, *AST↓, *Inflam?, *EMT↑, ROS?, TrxR1↓, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, IRE1↑, JNK↑, eff↝, DR5↑, Glycolysis↓, PKM2↓, ChemoSen↑, GPx4↓, HO-1↑,
2228- SK,    Shikonin induced Apoptosis Mediated by Endoplasmic Reticulum Stress in Colorectal Cancer Cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, HCT15 - in-vivo, NA, NA
Apoptosis↑, Bcl-2↓, Casp3↑, Casp9↑, cl‑PARP↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, JNK↑, eff↓, ER Stress↑, ROS↑, TumCG↓,
2189- SK,    PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells
- in-vitro, Melanoma, NA
PKM2↓, chemoPv↑, eff↝, lactateProd↓, ROS↑, *ROS?, *PKM2↓,
2188- SK,    Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment
- Review, Var, NA
ROS↑, EGFR↓, PI3K↓, Akt↓, angioG↓, Apoptosis↑, Necroptosis↑, GSH↓, Ca+2↓, MMP↓, ERK↓, p38↑, proCasp3↑, eff↓, VEGF↓, FOXO3↑, EGR1↑, SIRT1↑, RIP1↑, RIP3↑, BioAv↓, NF-kB↓, Half-Life↓,
2186- SK,    Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line
- in-vitro, HCC, HepG2 - in-vitro, HCC, HCCLM3
Glycolysis↓, PKM2↓, Apoptosis↑, ROS↑, OXPHOS⇅, eff↓,
2229- SK,    Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways
- in-vitro, Melanoma, A375
Apoptosis↑, TumAuto↑, TumCP↓, TumCCA↑, P21↑, cycD1/CCND1↓, ER Stress↑, p‑eIF2α↑, CHOP/DDIT3↑, cl‑Casp3↑, p38↑, LC3B-II↑, Beclin-1/ATG6↑, ROS↑, eff↓,
2227- SK,    Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,
2226- SK,    Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma
- in-vitro, HCC, HUH7 - in-vitro, HCC, Bel-7402
selectivity↑, ROS↑, eff↓, Akt↓, RIP1↓, NF-kB↓,
2224- SK,    Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells
- in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2
PYCR1↓, PI3K↓, Akt↓, mTOR↓, eff↑,
2217- SK,    Shikonin Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis to Attenuate Renal Ischemia/Reperfusion Injury by Activating the Sirt1/Nrf2/HO-1 Pathway
- in-vivo, Nor, NA - in-vitro, Nor, HK-2
*ER Stress↓, *SIRT1↑, *NRF2↑, *HO-1↑, *eff↓, *RenoP↑, *GRP78/BiP↓, *CHOP/DDIT3↓, *Casp12↓, *BAX↓, *cl‑Casp3↓,
2215- SK,  doxoR,    Shikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice
- in-vivo, Nor, NA
*cardioP↑, *ROS↓, *Inflam↓, *Mst1↓, *NRF2↑, *eff↓, *antiOx↑, *SOD↑, *GSH↑, *TNF-α↓, BAX↓, Bcl-2↑,
2210- SK,    Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC-803 via the Toll-like receptor 2/nuclear factor-kappa B pathway
- in-vitro, BC, MGC803
TumCA↓, TumCI↓, TumCMig↓, MMP2↓, MMP7↓, TLR2↓, p65↓, NF-kB↓, eff↑, ROS↑,
3051- SK,    Resveratrol mediates its anti-cancer effects by Nrf2 signaling pathway activation
- Review, Var, NA
Nrf1↑, Apoptosis↑, TumCP↓, eff⇅, chemoP↑, eff↑, VCAM-1↓, Hif1a↓,
3047- SK,    Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL-6/STAT3 signaling pathway
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
TumCG↓, p‑STAT3↓, ADAM17↓, Apoptosis↑, Casp3↑, cl‑PARP↑, cycD1/CCND1↓, cycE/CCNE↓, TumCCA↑, JAK1?, p‑JAK1↓, p‑JAK2↓, p‑eIF2α↑, eff↓, ROS↑, IL6↓,
2469- SK,    Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2
- in-vitro, Lung, H1975
Apoptosis↑, Pyro↑, Casp↑, cl‑PARP↑, GSDME↑, ROS↑, COX2/PTGS2↓, PDK1 / PDPK1↓, Akt↓, ERK↓, eff↓, eff↓, eff↑,
5101- SK,    Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis
- vitro+vivo, CRC, SW-620 - vitro+vivo, CRC, HCT116
Apoptosis↑, TumAuto↑, Gal1↑, TumCP↓, ROS↑, eff↑,
5100- SK,    Shikonin-induced necroptosis in nasopharyngeal carcinoma cells via ROS overproduction and upregulation of RIPK1/RIPK3/MLKL expression
- vitro+vivo, NPC, NA
TumCP↓, RIP1↑, ROS↑, Necroptosis↑, Casp3↑, Casp8↑, eff↓, TumCG↓,
1281- SK,    Enhancement of NK cells proliferation and function by Shikonin
- in-vivo, Colon, Caco-2
Perforin↑, GranB/GZMB↑, p‑ERK↑, p‑Akt↑, NK cell↑, eff↝,
2008- SK,  Cisplatin,    Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
ChemoSen↑, selectivity↑, i-ROS↑, DNAdam↑, MMP↓, TumCCA↑, eff↓, *toxicity↓,
2010- SK,    Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway
- in-vitro, Lung, H1975 - in-vitro, Lung, H1650 - in-vitro, Nor, CCD19
EGFR↓, selectivity↑, Casp↑, PARP↑, Apoptosis↑, ROS↑, eff↓, selectivity↑,
1344- SK,    Novel multiple apoptotic mechanism of shikonin in human glioma cells
- in-vitro, GBM, U87MG - in-vitro, GBM, Hs683 - in-vitro, GBM, M059K
ROS↑, GSH↓, MMP↓, P53↑, cl‑PARP↑, Catalase↓, SOD1↑, Bcl-2↓, BAX↑, eff↓,

Showing Research Papers: 1251 to 1300 of 1416
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1416

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 21,   ARE/EpRE↑, 1,   Catalase↓, 12,   Catalase↑, 4,   Catalase∅, 1,   Copper↓, 1,   CoQ10↑, 1,   cystine↓, 1,   DJ-1↓, 1,   ENOX2↓, 2,   ENOX2↑, 1,   Fenton↑, 16,   GCLM↓, 1,   GPx↓, 8,   GPx↑, 5,   GPx1↓, 1,   GPx1↑, 1,   GPx4↓, 16,   GSH↓, 74,   GSH↑, 3,   GSH↝, 1,   GSH∅, 1,   i-GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 12,   GSR↓, 3,   GSSG↓, 1,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   GSTs∅, 1,   H2O2?, 1,   H2O2↑, 17,   e-H2O2↓, 1,   i-H2O2↑, 1,   i-H2O2∅, 1,   mt-H2O2↑, 1,   HO-1↓, 8,   HO-1↑, 14,   HO-2↓, 1,   HO-2↑, 1,   hyperG↓, 1,   Iron↓, 1,   Iron↑, 11,   Iron↝, 2,   i-Iron↑, 2,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 4,   lipid-P↑, 40,   MDA↓, 3,   MDA↑, 11,   MPO↓, 1,   NADH↑, 1,   NADHdeh?, 1,   NADPH/NADP+↓, 1,   NQO1↓, 2,   NQO1↑, 1,   Nrf1↑, 2,   NRF2↓, 17,   NRF2↑, 20,   NRF2↝, 3,   p‑NRF2↑, 1,   Prx↓, 1,   Prx3↑, 1,   Prx4↑, 1,   Prx6↑, 2,   PrxII↓, 1,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 5,   ROS↓, 23,   ROS↑, 554,   ROS⇅, 7,   ROS↝, 5,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 6,   mt-ROS↑, 18,   RPM↑, 1,   SOD↓, 18,   SOD↑, 6,   mt-SOD↑, 1,   SOD1↓, 3,   SOD1↑, 2,   SOD2↓, 5,   SOD2↑, 4,   TAC↓, 3,   Thiols↓, 3,   i-Thiols↓, 1,   Trx↓, 6,   Trx↑, 1,   Trx1↓, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 30,   TrxR↑, 1,   TrxR1↓, 10,   TrxR1↑, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 6,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 5,   Ferritin↑, 1,   FTH1↓, 3,   IronCh↑, 4,   IRP1↑, 1,   Mets↑, 1,   NCOA4↑, 2,   Tf↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 3,   CDC25↓, 9,   CDC25↑, 2,   compI↓, 6,   compII↓, 1,   compIII↓, 1,   compIII↑, 1,   EGF↓, 1,   ETC↓, 10,   ETC↝, 1,   HSP60/HSPD1↑, 1,   Insulin↓, 4,   MCU↓, 1,   mitResp↓, 8,   mitResp↑, 2,   MKK7↓, 1,   mtDam↑, 45,   OCR↓, 13,   OCR↑, 3,   mt-OCR↓, 1,   OXPHOS↓, 9,   OXPHOS↑, 6,   OXPHOS⇅, 1,   OXPHOS↝, 3,   mt-OXPHOS↑, 2,   PDH↓, 4,   PDH↑, 1,   p‑PDH↓, 1,   PGC-1α↑, 4,   PINK1↑, 4,   SDH↓, 3,   SIRT3↓, 1,   SIRT3↑, 1,   TrxR2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   12LOX↓, 3,   5LO↓, 4,   ACC↓, 2,   ACC↑, 1,   p‑ACC↑, 1,   ACLY↓, 7,   p‑ACLY↓, 1,   ACSL4↑, 2,   adiP↑, 2,   ADO↓, 1,   ALAT↓, 2,   ALAT∅, 1,   ALDOA↓, 2,   AMP↑, 1,   AMPK↑, 25,   AMPK↝, 1,   p‑AMPK↑, 3,   ATP↓, 43,   ATP↑, 1,   ATP∅, 1,   i-ATP↓, 1,   i-ATP↑, 1,   Buty↑, 2,   CAIX/CA9↓, 2,   citrate↓, 1,   CPT1A↓, 1,   CRM↑, 1,   CRM↝, 1,   ECAR↓, 6,   ECAR↝, 1,   ENO1↓, 3,   FABP4↓, 1,   FAO↑, 1,   FASN↓, 3,   FASN↑, 2,   FBPase↑, 1,   GAPDH↓, 3,   GLS↓, 1,   glucoNG↑, 1,   glucose↓, 2,   glucose↑, 1,   glucose∅, 1,   GlucoseCon↓, 15,   GlucoseCon↑, 2,   GlucoseCon∅, 1,   glut↓, 1,   glyC↓, 1,   Glycolysis↓, 51,   Glycolysis↑, 3,   Glycolysis↝, 1,   GSK‐3β↓, 10,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 4,   p‑GSK‐3β↑, 1,   Histones↑, 1,   HK1↓, 1,   HK2?, 1,   HK2↓, 24,   HK2↑, 1,   HK2∅, 1,   HMG-CoA↓, 3,   KeyT↑, 1,   lactateProd↓, 26,   lactateProd↑, 4,   lactateProd∅, 1,   e-lactateProd↓, 1,   LDHA↓, 12,   LDHA↑, 1,   LDHA∅, 1,   LDL↓, 4,   lipidLev↓, 1,   lipidLev↑, 1,   lipoGen↓, 1,   MCT4↓, 1,   NAD↓, 2,   NADPH↓, 8,   NADPH↑, 1,   NH3↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 9,   PDKs↓, 4,   PFK↓, 6,   PFK1↓, 2,   PFK2?, 1,   PFK2↓, 1,   PFKP↓, 2,   PGK1↓, 2,   PGM1↓, 1,   PGM1∅, 1,   PKM2↓, 20,   p‑PKM2↓, 1,   polyA↓, 1,   PPP↓, 2,   PPP↑, 1,   Pyruv↓, 1,   SCD1↓, 3,   SCFAs↑, 2,   SIRT1↓, 9,   SIRT1↑, 6,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 2,   TCA↑, 2,   TCA↝, 1,   TS↓, 3,   UGDH↓, 2,   Warburg↓, 11,   Warburg↑, 1,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 18,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 12,   Apoptosis↑, 357,   mt-Apoptosis↑, 6,   ASC↓, 1,   ASK1↑, 2,   p‑ASK1↑, 1,   aSmase↑, 1,   BAD↓, 1,   BAD↑, 10,   Bak↓, 1,   Bak↑, 11,   BAX↓, 6,   BAX↑, 145,   Bax:Bcl2↑, 38,   Bcl-2↓, 155,   Bcl-2↑, 4,   Bcl-2∅, 1,   Bcl-xL↓, 38,   Bcl-xL↑, 3,   BID↓, 1,   BID↑, 7,   p‑BID↓, 1,   cl‑BID↑, 2,   BIM↑, 7,   BNIP3?, 2,   BNIP3↑, 1,   BNIP3↝, 1,   Casp↓, 1,   Casp↑, 55,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp12?, 1,   Casp12↑, 2,   pro‑Casp12↓, 1,   Casp2↑, 3,   Casp3↓, 4,   Casp3↑, 176,   cl‑Casp3↑, 51,   cl‑Casp3∅, 1,   proCasp3↓, 3,   proCasp3↑, 3,   CASP4↑, 1,   Casp6↑, 1,   Casp7↑, 20,   cl‑Casp7↑, 5,   Casp8↓, 2,   Casp8↑, 41,   Casp8∅, 2,   cl‑Casp8↑, 4,   proCasp8↑, 2,   Casp9↓, 1,   Casp9↑, 105,   cl‑Casp9↓, 1,   cl‑Casp9↑, 20,   proCasp9↓, 1,   proCasp9↑, 2,   cFLIP↓, 5,   Cupro↑, 3,   Cyt‑c↓, 1,   Cyt‑c↑, 121,   Cyt‑c↝, 1,   Diablo↑, 5,   DIDO1/DIO-1↑, 1,   DR5↑, 23,   Endon↑, 1,   FADD↑, 5,   Fap1↓, 1,   Fas↓, 2,   Fas↑, 15,   FasL↓, 1,   FasL↑, 13,   FasL⇅, 1,   Ferroptosis↓, 4,   Ferroptosis↑, 30,   GranB/GZMB↑, 1,   GranB/GZMB↝, 1,   GSDMD↑, 3,   GSDME↑, 1,   cl‑GSDME↑, 1,   GSDME-N↑, 2,   IAP1↓, 7,   IAP2/BIRC3↓, 3,   ICD↑, 5,   iNOS↓, 9,   iNOS↑, 1,   Mcl-1↓, 24,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 13,   MDM2↑, 1,   p‑MDM2↓, 1,   MLKL↑, 3,   p‑MLKL↓, 1,   MOMP↓, 2,   MOMP↑, 5,   Necroptosis↑, 7,   necrosis↑, 10,   NOXA↑, 6,   p38↓, 3,   p38↑, 25,   p‑p38↓, 1,   p‑p38↑, 12,   Paraptosis↑, 4,   Perforin↑, 1,   Perforin↝, 1,   PUMA↑, 7,   Pyro↑, 9,   RIP1↓, 2,   RIP1↑, 2,   RIP3↑, 3,   p‑RIP3↑, 2,   SK↓, 1,   survivin↓, 50,   TRAIL↑, 5,   TumCD↓, 4,   TumCD↑, 55,   TumCD∅, 2,   TUNEL↑, 1,   XIAP↓, 22,   YAP/TEAD↓, 7,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 115,   Akt↑, 6,   p‑Akt↓, 37,   p‑Akt↑, 4,   AKT1↓, 2,   AMPKα↑, 4,   BRAF↓, 1,   CaMKII ↓, 2,   CaMKII ↑, 1,   CK2↓, 2,   cMET↓, 2,   CREB↑, 1,   cSrc↓, 1,   DDIT4↑, 1,   EGFR↓, 24,   EGFR↑, 2,   p‑EGFR↓, 1,   ERK↓, 32,   ERK↑, 12,   p‑ERK↓, 12,   p‑ERK↑, 8,   e-ERK↑, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 8,   HGF/c-Met↓, 1,   Hippo↓, 2,   Hippo↝, 1,   IGF-1R↓, 2,   IGFR↓, 2,   IKKα↓, 7,   IKKα↑, 3,   p‑IKKα↓, 1,   IκB↑, 2,   p‑IκB↓, 2,   JAK↓, 2,   JAK1?, 1,   JAK1↓, 1,   p‑JAK1↓, 1,   JAK2↓, 8,   p‑JAK2↓, 5,   JNK↓, 6,   JNK↑, 33,   p‑JNK↑, 13,   LATS1↓, 1,   MAPK↓, 22,   MAPK↑, 16,   p‑MAPK↓, 1,   p‑MAPK↑, 6,   MEK↓, 2,   p‑MEK↓, 2,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 59,   mTOR↑, 3,   mTOR⇅, 1,   mTOR↝, 1,   p‑mTOR↓, 12,   mTORC2↓, 1,   mTORC2↑, 1,   p70S6↓, 2,   P70S6K↓, 2,   p‑P70S6K↓, 2,   p85S6K↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 82,   PI3K↑, 5,   p‑PI3K↓, 4,   PI3K/Akt↓, 1,   PIK3CA↓, 1,   PIK3CA↑, 1,   PKA↓, 3,   PKA↑, 1,   PKCδ↓, 5,   PTEN↓, 1,   PTEN↑, 15,   p‑PTEN↓, 1,   Raf↓, 3,   RAS↓, 4,   p‑RSK↑, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 7,   Src↓, 2,   p‑Src↓, 2,   STAT↓, 4,   STAT3↓, 54,   STAT3↑, 3,   STAT3⇅, 1,   STAT3↝, 1,   p‑STAT3↓, 15,   p‑STAT3↑, 2,   mt-STAT3↓, 1,   STAT6↓, 2,   p‑STAT6↓, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF3↑, 1,   ATF4↑, 10,   ATF4↝, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 2,   cJun↑, 3,   p‑cJun↑, 1,   cMyc↓, 31,   cMyc↑, 1,   DNMT1↓, 4,   DNMT1↑, 1,   DNMT3A↓, 1,   DNMTs↓, 5,   EZH2↓, 1,   FOXO1↑, 2,   FOXO3↓, 2,   FOXO3↑, 5,   FOXO4↑, 2,   H3↓, 3,   p‑H3↓, 1,   p‑H3↑, 1,   ac‑H3↓, 1,   ac‑H3↑, 2,   H3K27ac∅, 1,   H4↓, 1,   ac‑H4↓, 1,   ac‑H4↑, 1,   HATs↓, 1,   HATs↑, 1,   HDAC↓, 26,   HDAC1↓, 4,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 1,   HDAC3↓, 2,   HDAC8↓, 2,   IRF1↑, 1,   KLF2↓, 1,   KLF5↓, 1,   miR-124-3p↓, 1,   miR-129-5p↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-199↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-218↑, 1,   miR-22↑, 1,   miR-29b↑, 1,   miR-30a-5p↑, 2,   miR-375↑, 1,   miR-490↑, 1,   Myc↓, 5,   n-MYC↓, 1,   NDRG1↑, 1,   OCT4↓, 10,   other?, 4,   other↓, 8,   other↑, 18,   other↝, 63,   other∅, 2,   PhotoS↑, 3,   SD↑, 1,   SETBP1↓, 1,   sonoS↑, 2,   SOX2↓, 7,   SOX4↑, 1,   SOX9↓, 1,   SUV39H↓, 3,   TCF-4↓, 1,   TFE3↑, 2,   tumCV?, 1,   tumCV↓, 113,   tumCV↑, 3,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 33,   e-CRT↑, 1,   EDEM↑, 1,   eIF2α↓, 1,   eIF2α↑, 6,   p‑eIF2α↓, 1,   p‑eIF2α↑, 8,   ER Stress↓, 2,   ER Stress↑, 80,   ER Stress↝, 1,   ERStress↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 5,   GRP78/BiP↑, 18,   HSF1↓, 1,   HSP27↓, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 4,   e-HSP70/HSPA5↑, 1,   HSP90↓, 13,   HSP90↑, 2,   e-HSP90↑, 2,   ac‑HSP90↑, 1,   HSPs↑, 2,   HSPs∅, 1,   IRE1↑, 4,   NPL4↓, 2,   PERK↑, 9,   p‑PERK↓, 1,   p‑PERK↑, 1,   Proteasome↓, 4,   PSMB5↓, 1,   UPR↓, 1,   UPR↑, 14,   mt-UPR↑, 1,   XBP-1↑, 6,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

APA↑, 1,   ATG3↓, 1,   ATG5↑, 5,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 14,   p‑Beclin-1/ATG6↑, 1,   LAMP1?, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3B↑, 3,   LC3B-II↑, 5,   LC3II↑, 19,   LC3s↑, 2,   lysoMP↓, 1,   lysoMP↑, 1,   MitoP↑, 3,   p62↓, 11,   p62↑, 6,   p‑p62↑, 1,   PARK2↑, 4,   SESN2↑, 3,   TFEB↑, 1,   TumAuto↓, 5,   TumAuto↑, 75,   TumAuto↝, 1,   mt-TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   ATM↑, 5,   ATR↑, 1,   BRCA1↓, 2,   p‑BRCA1↑, 1,   BRCA2↓, 3,   DNA-PK↑, 2,   DNAdam↓, 5,   DNAdam↑, 97,   mt-DNAdam↑, 1,   DNArepair↓, 3,   hTERT/TERT↓, 7,   MDMX↓, 1,   NKX3.1↓, 2,   p16↑, 3,   P53↓, 6,   P53↑, 72,   P53↝, 3,   P53∅, 1,   p‑P53↑, 6,   p53 Wildtype↓, 1,   PARP↓, 6,   PARP↑, 16,   p‑PARP↑, 1,   cl‑PARP↑, 103,   cl‑PARP∅, 1,   proPARP↓, 1,   cl‑PARP1↑, 4,   PCNA↓, 12,   SIRT6↓, 2,   SIRT6↑, 1,   Telomerase↓, 16,   TOP1↓, 4,   TOP1↑, 1,   TOP1↝, 1,   TOP2↓, 2,   TOP2↑, 2,   TP53↓, 2,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↑, 12,   p‑γH2AX↑, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CDK1?, 1,   CDK1↓, 11,   p‑CDK1↓, 1,   p‑CDK1↑, 1,   CDK2↓, 20,   CDK4↓, 31,   CDK4↑, 3,   p‑CDK4↓, 1,   CDK6↓, 11,   CDK6↑, 5,   CDK8↓, 1,   CDKN2C/p18↑, 1,   cellSen↑, 1,   CHK1↓, 1,   Chk2↑, 2,   Cyc↓, 2,   cycA1/CCNA1↓, 8,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 22,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 56,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 2,   CycD3↑, 1,   cycE/CCNE↓, 13,   cycE/CCNE↑, 1,   cycF↑, 1,   E2Fs↓, 1,   GADD45A↑, 2,   Ki-67↓, 26,   mitA↓, 1,   mitA↑, 1,   p19↑, 1,   P21↓, 3,   P21↑, 57,   p27/CDKN1B↑, 22,   PLK1↓, 1,   RB1↑, 2,   p‑RB1↓, 4,   TubPol↓, 1,   TumCCA?, 1,   TumCCA↓, 6,   TumCCA↑, 228,   UBE2C↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 9,   ALDH1A1↓, 4,   BMI1↓, 3,   CD133↓, 9,   CD24↓, 3,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 48,   CSCs↑, 2,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 4,   FGF↓, 2,   Gli↓, 1,   Gli1↓, 6,   HH↓, 8,   HMGCR↓, 1,   IGF-1?, 1,   IGF-1↓, 18,   IGF-1↑, 1,   IGF-1↝, 1,   IGF-1∅, 1,   IGF-2↓, 1,   IGFBP1↓, 1,   IGFBP1↑, 3,   IGFBP3↑, 3,   Ki-67↓, 26,   Let-7↑, 1,   mTORC1↓, 4,   p‑mTORC1↓, 1,   Nanog↓, 10,   Nestin↓, 1,   NOTCH↓, 4,   NOTCH↑, 1,   NOTCH1↓, 5,   NOTCH1↑, 1,   NOTCH3↓, 1,   p300↓, 1,   Piezo1↑, 1,   PTCH1↓, 2,   Shh↓, 4,   Smo↓, 4,   STAT1↓, 1,   TumCG?, 1,   TumCG↓, 161,   TumCG↑, 5,   TumCG↝, 2,   TumCG∅, 1,   TumCP↓, 211,   TumCP↑, 7,   TumCP∅, 3,   Wnt?, 1,   Wnt↓, 27,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

Alix/AIP‑1↓, 1,   AntiAg↑, 2,   AP-1↓, 7,   ATPase↓, 1,   ATPase↑, 1,   AXL↓, 3,   BACH1↑, 1,   CA↓, 1,   Ca+2↓, 8,   Ca+2↑, 45,   Ca+2↝, 5,   i-Ca+2?, 1,   i-Ca+2↓, 1,   i-Ca+2↑, 3,   CAFs/TAFs↓, 2,   Cdc42↓, 2,   Cdc42↑, 1,   Chl↑, 1,   Chl∅, 1,   CTNNB1↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 25,   EMT↓, 44,   EMT↑, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 10,   p‑FAK↓, 2,   p‑FAK↑, 1,   FOSB↑, 1,   GLI2↓, 3,   hnRNPA1↓, 1,   ITGA1∅, 1,   ITGA5∅, 1,   ITGB1↓, 1,   ITGB1∅, 1,   ITGB3↓, 1,   ITGB3∅, 1,   ITGB4∅, 1,   KRAS↓, 2,   LEF1↓, 2,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 2,   p‑MET↓, 1,   MMP1↓, 6,   MMP13↓, 1,   MMP2↓, 52,   MMP2↑, 1,   MMP2∅, 1,   proMMP2↓, 1,   MMP3↓, 3,   MMP7↓, 4,   MMP9↓, 60,   MMP9↑, 2,   MMP9∅, 1,   MMPs↓, 20,   MTA1↓, 1,   MUC1↑, 1,   N-cadherin↓, 9,   N-cadherin↑, 1,   NEDD9↓, 1,   p‑p44↓, 1,   PAK1↓, 3,   PAK1↑, 1,   PDGF↓, 3,   Rac1↓, 1,   Rho↓, 5,   ROCK1↓, 2,   Slug↓, 4,   Smad1↓, 1,   SMAD3↓, 2,   Snail?, 1,   Snail↓, 16,   SPARC↑, 1,   TET1?, 1,   TET1↑, 2,   TGF-β↓, 5,   TGF-β1↓, 2,   TIMP1↓, 1,   TIMP1↑, 2,   TIMP2↓, 1,   TIMP2↑, 6,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 2,   TumCI?, 1,   TumCI↓, 62,   TumCI↑, 1,   TumCMig↓, 66,   TumCMig↑, 2,   TumMeta↓, 62,   TumMeta↑, 5,   TumPF↓, 1,   Twist↓, 10,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 9,   uPAR↓, 2,   Vim↓, 16,   Vim↑, 1,   Zeb1↓, 8,   ZEB2↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 39,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 91,   angioG↑, 4,   angioG∅, 1,   CD31/PECAM-1↓, 1,   EGR1↑, 1,   Endoglin↑, 1,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 48,   Hif1a↑, 3,   Hypoxia↓, 1,   LOX1↓, 1,   NO↓, 1,   NO↑, 8,   PHDs↓, 1,   VCAM-1↓, 2,   VEGF↓, 65,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 2,   BBB↑, 8,   BBB∅, 1,   CellMemb↓, 1,   CellMemb↑, 6,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN2↓, 1,   CLDN2↑, 1,   CTR1↑, 1,   EPR↓, 1,   EPR↑, 19,   EPR↝, 1,   GLUT1↓, 15,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↓, 2,   GLUT4↓, 3,   IBI↑, 2,   KCNH2/hERG↓, 1,   LAT↓, 1,   MMP?, 1,   MMP↓, 198,   MMP↑, 1,   MPT↑, 11,   NHE1↓, 2,   OATPs↓, 1,   OCLN↑, 1,   SLC12A5↓, 2,   SMCT1∅, 1,   sonoP↑, 2,   TJ↓, 1,   TJ↑, 1,   TRPM7↓, 2,   TRPV1↑, 5,   VGCC↑, 1,   VGSC↑, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD14↓, 1,   CD4+↓, 1,   CD4+↑, 2,   CD44↓, 12,   CD47↓, 1,   CD8+↑, 9,   cDC2↓, 4,   cGAS–STING↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 48,   COX2/PTGS2↑, 5,   CR3↝, 1,   CXCR2↓, 1,   CXCR4↓, 11,   DCells↑, 1,   Dectin1↝, 1,   DR4↑, 6,   DR4∅, 1,   DR6↑, 1,   Eos↑, 1,   Gal1↑, 1,   HCAR2↑, 1,   HMGB1↓, 2,   e-HMGB1↑, 1,   ICAM-1↓, 3,   IFN-γ↓, 1,   IFN-γ↑, 5,   Igs↑, 2,   IL-1Ra↑, 1,   IL1↓, 3,   IL1↑, 2,   IL10↓, 3,   IL10↑, 2,   IL12↓, 1,   IL12↑, 1,   IL17↑, 1,   IL18↑, 1,   IL1R2↑, 1,   IL1RL1/ST2↑, 1,   IL1α↓, 1,   IL1β↓, 12,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 6,   IL4↓, 3,   IL6↓, 25,   IL6↑, 1,   IL7↓, 1,   IL8↓, 6,   IL8↑, 1,   Imm↑, 36,   Imm↝, 3,   Inflam↓, 33,   Inflam↑, 1,   IRAK4↓, 1,   pol-M1↑, 1,   pol-M1↝, 1,   M2 MC↓, 3,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 3,   MIP2↓, 1,   Neut↓, 1,   NF-kB↓, 105,   NF-kB↑, 5,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 15,   NLRP3↓, 2,   NLRP3↑, 3,   p50↓, 1,   p65↓, 7,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 12,   PD-L1↑, 4,   PDT+↓, 1,   PGE2↓, 13,   PSA↓, 13,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 2,   T-Cell↝, 1,   TCF↓, 3,   TCF↝, 1,   TLR1↑, 1,   TLR2↓, 1,   TLR4↓, 5,   TNF-α↓, 19,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRAF1↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   GFAP↓, 1,   pH↑, 7,   pH↝, 2,   pH∅, 1,   e-pH↓, 1,   e-pH↑, 6,   i-pH↓, 1,   TAMS↑, 1,   Temp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   ACTH↓, 1,   AR↓, 19,   AR↑, 1,   AR↝, 1,   AR-FL↓, 1,   AR-V7↑, 1,   CYP11A1↓, 1,   CYP19↓, 1,   CYP24A1↓, 1,   ER-α36↓, 1,   ER(estro)↓, 2,   Estro↝, 1,   FKBP5↓, 1,   GR↓, 1,   Leptin↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 3,   RANKL↓, 1,   SRC3↓, 1,   SXR↑, 1,   VDR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCC2↓, 1,   BioAv↓, 49,   BioAv↑, 64,   BioAv↝, 12,   BioEnh?, 1,   BioEnh↑, 10,   CBR1↓, 1,   chemoR↓, 2,   ChemoSen?, 1,   ChemoSen↓, 6,   ChemoSen↑, 209,   ChemoSen↝, 1,   CompStab↓, 3,   CompStab↑, 4,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   DDS↑, 10,   Dose?, 16,   Dose↓, 8,   Dose↑, 22,   Dose⇅, 1,   Dose↝, 153,   Dose∅, 29,   DrugR↓, 1,   eff?, 5,   eff↓, 440,   eff↑, 816,   eff⇅, 4,   eff↝, 143,   eff∅, 26,   GSTA1↓, 2,   GSTZ1↓, 1,   GSTZ1↝, 1,   GSTZ1∅, 1,   Half-Life↓, 16,   Half-Life↑, 9,   Half-Life↝, 13,   Half-Life∅, 1,   MDR1↓, 6,   MRP↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 21,   P-gp/ABCB1∅, 1,   P450↓, 2,   RadioS↓, 1,   RadioS↑, 81,   RadioS↝, 1,   RadioS∅, 1,   selectivity?, 2,   selectivity↓, 3,   selectivity↑, 199,   selectivity↝, 1,   selectivity∅, 2,   Synergy↑, 132,   Synergy∅, 1,   TET2↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 3,   ALAT↓, 2,   ALAT∅, 1,   ALB∅, 1,   ALP↓, 2,   AR↓, 19,   AR↑, 1,   AR↝, 1,   ascitic↓, 1,   AST↓, 2,   AST∅, 1,   BG↓, 6,   BMD↑, 2,   BP↓, 1,   BRAF↓, 1,   BRCA1↓, 2,   p‑BRCA1↑, 1,   CA125↓, 1,   CA125∅, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 2,   CRP∅, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 24,   EGFR↑, 2,   p‑EGFR↓, 1,   EZH2↓, 1,   Ferritin↓, 5,   Ferritin↑, 1,   Hcy/homoC↓, 4,   Hcy/homoC↝, 1,   HER2/EBBR2↓, 8,   HOMA↓, 1,   hTERT/TERT↓, 7,   IL6↓, 25,   IL6↑, 1,   KeyT↑, 1,   KRAS↓, 2,   LDH?, 1,   LDH↓, 8,   LDH↑, 4,   LDH↝, 1,   i-LDH↓, 1,   Myc↓, 5,   NOS2↑, 1,   NSE↓, 1,   PD-L1↓, 12,   PD-L1↑, 4,   PSA↓, 13,   TP53↓, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↓, 3,   AntiCan↑, 80,   AntiCan∅, 1,   AntiDiabetic↑, 1,   antiNeop↑, 4,   AntiTum↓, 3,   AntiTum↑, 34,   AntiTum⇅, 1,   cachexia↓, 2,   cardioP↑, 10,   CardioT↓, 1,   CardioT↑, 2,   CardioT↝, 1,   chemoP↑, 40,   chemoP↝, 1,   chemoPv↑, 19,   ChemoSideEff↓, 15,   cognitive↑, 5,   fatigue↓, 3,   hepatoP↓, 1,   hepatoP↑, 8,   memory↑, 2,   motorD↑, 1,   Mucositis↓, 1,   MusCon↓, 2,   neuroP↑, 7,   NKG2D↑, 1,   NP/CIPN↓, 1,   NP/CIPN↑, 2,   OS?, 2,   OS↑, 65,   OS↝, 1,   OS∅, 1,   PARP16↓, 1,   PFS?, 1,   PFS↑, 3,   QoL↑, 12,   QoL∅, 3,   radioP↑, 20,   radioP↝, 1,   Remission↑, 4,   RenoP↑, 4,   Risk↓, 35,   Risk↑, 1,   Risk∅, 4,   Sleep↑, 1,   Strength∅, 1,   toxicity↓, 51,   toxicity↑, 8,   toxicity⇅, 1,   toxicity↝, 25,   toxicity∅, 7,   TumVol↓, 58,   TumW↓, 29,   Weight↓, 1,   Weight↑, 7,   Weight∅, 5,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 2,   Bacteria↓, 4,   Dectin1↝, 1,   GutMicro↑, 13,   GutMicro↝, 3,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 1244

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 10,   antiOx↑, 99,   mt-antiOx↑, 1,   ARE↑, 2,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 37,   Copper↓, 1,   CoQ10↑, 1,   DPPH↓, 1,   Fenton↓, 3,   GPx↑, 26,   GPx1↑, 1,   GPx4↓, 1,   GPx4↑, 3,   GPx4∅, 1,   GSH↓, 3,   GSH↑, 48,   GSR↑, 4,   GSTs↑, 8,   H2O2↓, 5,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 5,   HDL∅, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 28,   HO-1↝, 1,   HO-1∅, 1,   hyperG↓, 1,   Iron↓, 3,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 33,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA↓, 30,   MDA↑, 1,   MDA∅, 1,   MPO↓, 5,   MPO↑, 1,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 7,   Nrf1↑, 1,   NRF2↓, 4,   NRF2↑, 51,   NRF2⇅, 1,   NRF2∅, 1,   Prx↑, 1,   RNS↓, 5,   ROS?, 4,   ROS↓, 133,   ROS↑, 14,   ROS⇅, 3,   ROS↝, 1,   ROS∅, 7,   mt-ROS↓, 1,   mt-ROS↑, 2,   selenoP↑, 4,   SOD↓, 3,   SOD↑, 59,   SOD1↑, 2,   TAC↑, 7,   TBARS↓, 4,   Trx↑, 2,   TrxR↑, 1,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   IronCh↑, 6,   IronCh↝, 1,   Mets↝, 1,   NCOA4↝, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   compII↑, 1,   compIII↓, 1,   compIII↑, 1,   DRP1/DNM1L↑, 1,   ETC↓, 1,   ETC↑, 1,   FIS1↓, 1,   FIS1↑, 1,   Insulin↓, 3,   Insulin↑, 1,   mitResp↑, 2,   mtDam↓, 6,   OCR↑, 1,   mt-OCR↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1,   12LOX↓, 3,   5-HETE↓, 1,   5LO↓, 3,   ACSL4∅, 1,   adiP↓, 1,   adiP↑, 2,   ALAT↓, 15,   ALAT∅, 1,   AMPK↓, 1,   AMPK↑, 6,   ATP↓, 3,   ATP↑, 9,   BHB↑, 1,   cAMP↑, 2,   DHA↑, 1,   ECAR↓, 1,   ECAR↑, 1,   Eic↓, 1,   mt-FAO↑, 1,   glucose↓, 4,   glucose↑, 1,   GlucoseCon↑, 4,   Glycolysis↓, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↑, 1,   KeyT↑, 4,   lactateProd↓, 1,   LDL↓, 14,   lipidLev↓, 1,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 2,   NADPH↑, 3,   PKM2↓, 2,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 8,   SIRT2↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 15,   Apoptosis∅, 2,   ASK1↓, 1,   BAX↓, 6,   BAX↑, 2,   Bax:Bcl2↓, 2,   Bcl-2↓, 2,   Bcl-2↑, 3,   Bcl-2∅, 1,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   Casp12↓, 2,   Casp3↓, 16,   Casp3↑, 2,   Casp3∅, 1,   cl‑Casp3↓, 2,   cl‑Casp8↑, 1,   Casp9↓, 6,   Casp9↑, 1,   Cyt‑c↓, 5,   Cyt‑c↑, 3,   Cyt‑c∅, 3,   Ferroptosis↓, 4,   GranB/GZMB↓, 1,   HEY1↑, 1,   iNOS↓, 13,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 1,   p38↑, 2,   p‑p38↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 7,   e-Akt↑, 1,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 1,   CREB↑, 1,   ERK↓, 1,   ERK↑, 4,   e-ERK↑, 1,   HCAR2↑, 1,   IKKα↓, 1,   IκB?, 1,   JAK2↑, 1,   JNK↓, 4,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 7,   MAPK↑, 6,   Mst1↓, 1,   mTOR↓, 5,   mTOR↑, 1,   mTOR↝, 1,   p‑mTOR↓, 1,   p‑mTOR↑, 1,   PI3K↓, 4,   PI3K↑, 4,   PKA↑, 2,   PKCδ?, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PP2A↑, 1,   PTEN↓, 2,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF4↓, 1,   FOXO↑, 1,   HDAC↓, 1,   other?, 4,   other↓, 9,   other↑, 27,   other↝, 44,   SOX9↑, 1,   tumCV↓, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 6,   ER Stress↑, 1,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   HSF1↑, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSPs↑, 3,   IRE1↓, 2,   p‑PERK↑, 1,   UPR↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

CTSZ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   MitoP↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 13,   DNAdam↑, 2,   DNArepair↑, 3,   P53↑, 2,   PARP↓, 1,   γH2AX↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Choline↑, 1,   Diff↑, 4,   Diff↝, 1,   FGF↑, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   neuroG↑, 1,   NOTCH↑, 1,   TumCP↓, 2,   tyrosinase↓, 1,   Wnt↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 12,   ARG1/2↑, 1,   Ca+2↓, 3,   Ca+2↑, 7,   Ca+2↝, 4,   cal2↓, 1,   Cartilage↑, 1,   COL1↓, 1,   COL2A1↑, 1,   E-cadherin↑, 1,   EMT↓, 2,   EMT↑, 1,   F-actin↑, 1,   FAK↑, 2,   MLC2/MYL9↝, 1,   MMP13↓, 1,   MMP2↓, 2,   MMP2↑, 2,   MMP9↓, 11,   MMP9↑, 2,   MMPs↓, 1,   MMPs↑, 1,   PAI-1/SERPINE1↓, 1,   SMAD3↓, 2,   Snail↑, 1,   TG2/TGase↓, 1,   TGF-β↓, 1,   TGF-β↑, 4,   TGF-β1↓, 1,   TIMP1↓, 2,   TIMP1↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   Twist↑, 1,   Vim↓, 1,   Vim↑, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   CD31/PECAM-1↑, 1,   eNOS↑, 1,   Hif1a↓, 2,   Hif1a↑, 2,   Hif1a∅, 1,   NO?, 1,   NO↓, 13,   NO↑, 4,   VCAM-1↓, 2,   VEGF↓, 2,   VEGF↑, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 38,   BBB↝, 1,   BBB∅, 2,   CellMemb↑, 1,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN1↝, 1,   EPR↑, 1,   GastroP↑, 5,   GLUT1↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 1,   ketosis↑, 1,   MMP↓, 4,   MMP↑, 10,   MMP↝, 1,   MMP∅, 2,   MPT↑, 1,   OCLN↝, 1,   TJ↓, 1,   TJ↑, 2,   TRPV3↑, 1,   VGCC↑, 2,   VGCC⇅, 1,   VGSC↓, 1,   ZO-1↓, 1,   ZO-1↑, 1,   ZO-1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD25+↑, 1,   CD4+↑, 3,   CD8+↑, 2,   COX1↓, 4,   COX2/PTGS2↓, 22,   CXCR4↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HCAR2↑, 1,   HMGB1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 2,   IgE↓, 1,   IL1↓, 2,   IL10?, 1,   IL10↓, 2,   IL10↑, 9,   IL10∅, 1,   IL17↓, 7,   IL17∅, 1,   IL18↓, 1,   IL1α↓, 1,   IL1β↓, 26,   IL2↓, 2,   IL22↓, 1,   IL23↓, 1,   IL4↓, 1,   IL4↑, 3,   IL4∅, 1,   IL5↑, 1,   IL6↓, 33,   IL6↑, 4,   IL8↓, 3,   Imm↑, 18,   Imm⇅, 1,   INF-γ↓, 1,   Inflam?, 1,   Inflam↓, 130,   Inflam↑, 2,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   MCP1/CCL2↓, 4,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MyD88↓, 2,   NeuroI↓, 1,   NF-kB↓, 31,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 5,   NLRP3↑, 1,   p65↓, 1,   PAF↓, 1,   PGE2↓, 9,   PSA↓, 1,   TLR1↓, 1,   TLR2↓, 2,   TLR4↓, 4,   TNF-α↓, 48,   TNF-α↑, 1,   Treg lymp↑, 1,   Treg lymp↝, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,   Temp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 1,   5HT↓, 1,   5HT↑, 2,   Ach?, 1,   Ach↑, 6,   AChE↓, 24,   AChE∅, 2,   ADAM10↑, 1,   BChE↓, 9,   BDNF↑, 15,   BrainVol↑, 1,   BrainVol∅, 1,   ChAT↑, 1,   GABA↑, 3,   MAOA↓, 2,   NMDAR↑, 1,   PSD95↑, 1,   SNAP25↑, 1,   TrkB↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 4,   Aβ↓, 32,   Aβ42↓, 1,   BACE/β-secretase↓, 8,   IDE↑, 1,   tau↓, 4,   p‑tau↓, 8,   XO↝, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

BNP↓, 1,   GPER↑, 1,   GR↑, 2,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 36,   BioAv↑, 66,   BioAv⇅, 1,   BioAv↝, 24,   BioAv∅, 1,   BioEnh↑, 8,   ChemoSen↑, 1,   CompStab↓, 1,   CompStab↑, 5,   CompStab↝, 2,   CYP1A1↓, 1,   CYP2C19↓, 1,   CYP2C8↓, 1,   CYP2C9↓, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose?, 2,   Dose↓, 8,   Dose↑, 7,   Dose⇅, 1,   Dose↝, 93,   Dose∅, 2,   eff?, 2,   eff↓, 37,   eff↑, 264,   eff↝, 36,   eff∅, 2,   GSTA1↓, 2,   GSTA1↑, 1,   Half-Life↓, 5,   Half-Life↑, 7,   Half-Life⇅, 1,   Half-Life↝, 14,   Half-Life∅, 4,   P-gp/ABCB1↓, 3,   P450↓, 1,   selectivity↑, 2,   Synergy↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALAT∅, 1,   ALP↓, 4,   ALP↑, 1,   anemia↓, 1,   AST↓, 15,   AST∅, 1,   BG↓, 1,   Bil↓, 1,   BloodF↑, 3,   BMD↑, 7,   BP↓, 16,   BP∅, 1,   BUN↓, 3,   creat↓, 6,   CRP↓, 7,   Ferritin↓, 1,   FEV1↑, 2,   Hcy/homoC↓, 2,   HemoG↑, 1,   hs-CRP↓, 1,   IL6↓, 33,   IL6↑, 4,   KeyT↑, 4,   LDH↓, 6,   LDH↑, 1,   LDH∅, 1,   NLR↓, 1,   NOS2↓, 2,   PEF↑, 1,   PSA↓, 1,   PV↓, 1,   RBC↑, 1,   SpO2↑, 1,   TC↓, 1,   TMAO↑, 3,   TMAO⇅, 1,   UFR?, 1,   UFR↑, 1,   UR↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll↑, 15,   antiAll∅, 1,   AntiArt↑, 7,   AntiCan↑, 11,   antiD↓, 1,   AntiDiabetic↑, 18,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 3,   BOLD↑, 2,   Bone Healing↑, 1,   cachexia↓, 1,   cardioP↑, 37,   CardioT↓, 3,   chemoP↑, 10,   chemoPv↑, 5,   cognitive?, 1,   cognitive↓, 3,   cognitive↑, 71,   cognitive∅, 1,   diuretic↑, 1,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 31,   IPSS↝, 1,   Learn↑, 1,   memory↓, 2,   memory↑, 41,   memory∅, 1,   Mood?, 1,   Mood↑, 5,   motorD↓, 1,   motorD↑, 13,   MusCon↓, 1,   Nausea↓, 1,   neuroP?, 1,   neuroP↑, 73,   Obesity↓, 8,   OS↓, 1,   OS↑, 5,   Pain↓, 9,   PDE4↓, 1,   QoL↑, 1,   radioP↑, 4,   RenoP↑, 15,   Risk↓, 8,   Risk↑, 2,   Sleep↑, 5,   Strength↑, 2,   Stress↓, 3,   Stroke↓, 8,   toxicity?, 3,   toxicity↓, 78,   toxicity↑, 7,   toxicity↝, 11,   toxicity∅, 27,   Vomit↓, 1,   Weight↓, 4,   Weight↑, 1,   Weight↝, 1,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 11,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 7,   AntiFungal↑, 4,   AntiP↓, 1,   AntiP↑, 2,   AntiViral↑, 13,   Bacteria↓, 26,   Diar↓, 1,   Dysb↓, 1,   GutMicro↑, 15,   GutMicro↝, 1,   Inf↓, 1,   Sepsis↓, 7,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2,   Ingr↝, 5,   Phen↑, 1,  
Total Targets: 612

Scientific Paper Hit Count for: eff, efficacy
64 Silver-NanoParticles
59 Magnetic Fields
33 Sulforaphane (mainly Broccoli)
28 Thymoquinone
27 Curcumin
26 immunotherapy
26 Shikonin
25 Chemotherapy
25 Vitamin C (Ascorbic Acid)
23 chitosan
22 Selenite (Sodium)
21 Radiotherapy/Radiation
21 Baicalein
21 Selenium NanoParticles
20 Piperlongumine
19 Copper and Cu NanoParticles
19 EGCG (Epigallocatechin Gallate)
18 Artemisinin
17 Magnetic Field Rotating
16 Melatonin
16 Berberine
16 Exercise
15 Chlorogenic acid
14 Apigenin (mainly Parsley)
14 Luteolin
14 Phenylbutyrate
14 Caffeic acid
14 Capsaicin
14 Resveratrol
14 Quercetin
14 Gambogic Acid
13 Selenium
13 diet FMD Fasting Mimicking Diet
12 Gold NanoParticles
12 Citric Acid
12 Ashwagandha(Withaferin A)
12 Propolis -bee glue
12 Folic Acid, Vit B9
12 Dichloroacetate
12 Hydrogen Gas
11 3-bromopyruvate
11 Cisplatin
11 Betulinic acid
11 Ivermectin
11 Lycopene
11 Phenethyl isothiocyanate
10 Vitamin D3
10 Choline
10 diet Methionine-Restricted Diet
10 Disulfiram
10 Honokiol
9 Auranofin
9 Metformin
9 borneol
9 Electrical Pulses
9 Formononetin
9 Bicarbonate(Sodium)
8 Photodynamic Therapy
8 Fenbendazole
8 SonoDynamic Therapy UltraSound
8 chaetocin
8 doxorubicin
8 Fisetin
8 Hyperthermia
8 Plumbagin
8 Rosmarinic acid
7 Coenzyme Q10
7 Docetaxel
7 Boron
7 buckwheat sprouts
7 Ellagic acid
7 Chrysin
7 Dandelion Root
7 Juglone
7 VitK3,menadione
7 mebendazole
7 salinomycin
6 Alpha-Lipoic-Acid
6 beta-glucans
6 isoorientin
6 Carnosic acid
6 Celastrol
6 Vitamin B12
6 Chlorophyllin
6 Docosahexaenoic Acid
6 Eugenol
6 MCT oil
6 Flaxseed/Linseed
6 Ginger/6-Shogaol/Gingerol
6 isoquercitrin
6 MCT, metronomic chemo
6 Parthenolide
6 Vitamin K2
5 Astragalus
5 Akkermansia
5 Bevacizumab (brand Avastin)
5 Ascorbyl Palmitate
5 Lutein
5 Bifidobacterium
5 Boswellia (frankincense)
5 Piperine
5 Silymarin (Milk Thistle) silibinin
5 Cynaropicrin
5 Diclofenac
5 eicosapentaenoic acid
5 diet Plant based
5 Lemongrass Extract/Citral
5 Ginkgo biloba-EGb 761
5 Gossypol/AT-101
5 Isoliquiritigenin
5 Licochalcone A
5 Moringa oleifera
5 Nimbolide
5 Spermidine
5 Urolithin
4 chemodynamic therapy
4 EMF
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Allicin (mainly Garlic)
4 almonertinib
4 Berbamine
4 α-Bisabolol / Chamomile oil
4 Butyrate
4 capecitabine
4 Carvacrol
4 Cat’s Claw
4 Centella asiatica / Gotu kola → asiaticoside
4 CUSP9
4 diet Short Term Fasting
4 Echinacea
4 Kaempferol
4 phytic acid, Inositol hexakisphosphate
4 Fucoidan
4 Ginkgolide B
4 Ginseng
4 HydroxyCitric Acid
4 Magnolol
4 Isobavachalcone
4 Matrine
4 methylseleninic acid
4 Methylsulfonylmethane
4 Propyl gallate
4 Pterostilbene
4 Terpinen-4-ol / Tea Tree Oil
4 Whole Body Vibration
3 cetuximab
3 5-fluorouracil
3 Anthocyanins
3 Aspirin
3 Atorvastatin
3 Aloe anthraquinones
3 bempedoic acid
3 beta-carotene(VitA)
3 Zeaxanthin
3 Bortezomib
3 Bullatacin
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 Thymol-Thymus vulgaris
3 Cannabidiol
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Crocetin
3 Cysteamine
3 erastin
3 Gallic acid
3 Gamma-aminobutyric acid
3 Ginkgo biloba
3 Lemon Balm/Melissa officinalis
3 Germanium Organic/Ge-132 / propagermanium (organogermanium)
3 Gemcitabine (Gemzar)
3 Hibiscus sabdariffa
3 HydroxyTyrosol
3 iodine
3 Inulin Prebiotic
3 isoflavones
3 Licorice
3 Lactoferrin/Talactoferrin
3 nicotinamide adenine dinucleotide
3 Radio Frequency
3 Sulfasalazine
3 Taurine
3 Vitamin B1/Thiamine
2 1,8-Cineole
2 2-DeoxyGlucose
2 Glucose
2 Zinc
2 Andrographis
2 Anti-oxidants
2 Vitamin A, Retinoic Acid
2 Aromatherapy
2 Astaxanthin
2 Arsenic trioxide
2 Baicalin
2 Huperzine A/Huperzia serrata
2 Beta-Caryophyllene
2 Bufalin/Huachansu
2 temozolomide
2 probiotics
2 brusatol
2 Vitexin
2 Isovitexin
2 Rutin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Caffeine
2 Calcium
2 Celecoxib
2 Hydroxycinnamic-acid
2 Calorie Restriction Mimetics
2 Cyclopamine
2 Dichloroacetophenone(2,2-)
2 Deguelin
2 Date Fruit Extract
2 diet Ketogenic
2 Oxygen, Hyperbaric
2 D-limonene
2 statins
2 Emodin
2 Vitamin E
2 ferumoxytol
2 Paclitaxel/Taxol
2 SDG/lignans
2 tamoxifen
2 Garcinol
2 Geldanamycin
2 γ-linolenic acid (Borage Oil)
2 Grapeseed extract
2 Orlistat
2 hydroxychloroquine
2 Helleborus niger extracts – Christmas Rose
2 Hyperoside
2 itraconazole
2 Potassium
2 lambertianic acid
2 Lapachol
2 Methylene blue
2 Methyl Jasmonate
2 Magnesium
2 Mistletoe/Viscum album Extracts
2 Naringin
2 Marjoram (Origanum majorana)
2 Rauwolfia serpentina/Indian Snakeroot
2 Aflavin-3,3′-digallate
2 tetrathiomolybdate
2 Ursolic acid
1 5-Aminolevulinic acid
1 Anzaroot, Astragalus fasciculifolius Bioss
1 wortmannin
1 Resiquimod
1 Aidi injection
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Amodiaquine
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Sorafenib (brand name Nexavar)
1 Trastuzumab
1 Biochanin A
1 Brucea javanica
1 Bacopa monnieri
1 Bromelain
1 Bruteridin(bergamot juice)
1 urea
1 Cannabichromene
1 Beta‐Lapachone
1 Cinnamon
1 Carica papaya leaf extract
1 Camptothecin
1 irinotecan
1 Carvone
1 Polyphenols
1 Black phosphorus
1 Cucurbitacin
1 gefitinib, erlotinib
1 Dasatinib/Phyrago
1 Dihydrocaffeic Acid
1 diet Fermented Foods
1 Dipyridamole
1 Protocatechuic acid
1 PXD, phenoxodiol
1 Eurycomanone
1 flavonoids
1 Flickering Light Stimulation
1 Flaxseed Oil
1 Galloflavin
1 verapamil
1 Salvia officinalis
1 Germanium inorganic
1 Geraniol
1 Germanium-Spirogermanium
1 Ginkgetin
1 Glabrescione B
1 Graviola
1 High-Ozonide Oil
1 Indole-3-carbinol
1 entinostat
1 Recombinant Methioninase
1 Lactobacillus
1 Laetrile B17 Amygdalin
1 Lapatinib
1 low dose naltrexone
1 Lecithin
1 Linalool
1 Mung Bean Sprouts
1 Modified Citrus Pectin
1 carboplatin
1 Methylglyoxal
1 magnetic nanoparticles
1 Mushroom Lion’s Mane
1 Mushroom Reishi
1 Myricetin
1 No Product/Mechanism Only
1 Oleocanthal
1 Peppermint
1 sericin
1 Phosphatidylserine
1 Pumpkin Seed Oil / Cucurbita pepo
1 Tamsulosin
1 enzalutamide
1 Rhein
1 Oxaliplatin
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 Iron
1 Squalene
1 Glutathione
1 Sutherlandioside D
1 Triphala
1 triptolide
1 Tumor Treating Fields
1 Turmerones
1 Vitamin B3,Niacin
1 Vitamin B5,Pantothenic Acid
1 Vitamin B6,pyridoxine
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:961  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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