Cancer Database Query Results

Scientific Papers found: Click to Expand⟱

5510-

bemA,

Combined inhibition of ACLY and CDK4/6 reduces cancer cell growth and invasion

in-vitro,

BC,

MDA-MB-231

in-vitro,

PC,

eff↑, Apoptosis↑, TumCI↓, ACLY↓, LDL↓, eff↑, TumCP↓,

5509-

bemA,

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Review,

Nor,

LDL↓, AMPK↑, ACLY↓,

5511-

bemA,

Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation

in-vitro,

Var,

ACLY↓, PD-L1↑, mtDam↑, cGAS–STING↑, LDL↓, eff↑,

5512-

bemA,

Recent advance of ATP citrate lyase inhibitors for the treatment of cancer and related diseases

Review,

Var,

ACLY↓, other↝, CSCs↓,

5513-

bemA,

ACLY inhibition promotes tumour immunity and suppresses liver cancer

in-vitro,

Liver,

ACLY↓, AMPK↑, eff↑, other↝, eff↝,

5514-

bemA,

Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients

Trial,

Nor,

13,970 patients underwent randomization; 6992 were assigned to the bempedoic acid group

*ACLY↓, *LDL↓, *MusCon↓, Dose↝, cardioP↑,

5582-

BetA,

Targeting mitochondrial apoptosis by betulinic acid in human cancers

Review,

Var,

Apoptosis↑, MMP↓, Cyt‑c↑, ROS↑, NF-kB↑, angioG↓, mtDam↑, TOP1↓, selectivity↑, ChemoSen↑, TumCG↓, chemoPv↑, RadioS↑,

5593-

BetA,

Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth

in-vitro,

Lung,

Sp1/3/4↓, cycA1/CCNA1↓, p‑RB1↓, TumCCA↑,

5592-

BetA,

Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells

in-vitro,

Liver,

HepG2

10 to 15 mg/mL

in-vitro,

Cerv,

HeLa

Casp3↑, Casp9↑, cl‑PARP↑, Apoptosis↑, Cyt‑c↑, MMP↓,

5591-

BetA,

Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment

Review,

BC,

IC50 values ranging from 1 to 13.0 μg mL−1

BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,

5590-

BetA,

Betulinic acid a radiosensitizer in head and neck squamous cell carcinoma cell lines

in-vitro,

HNSCC,

SCC9

in-vitro,

HNSCC,

SCC25

RadioS↑,

5589-

BetA,

Advancements in Betulinic Acid-Loaded Nanoformulations for Enhanced Anti-Tumor Therapy

Review,

Var,

BioAv↓, toxicity↝, BioAv↑, Half-Life↑,

5588-

BetA,

Therapeutic applications of betulinic acid nanoformulations

Review,

Var,

BioAv↓, Half-Life↓, BioAv↑, Half-Life↑,

5587-

BetA,

Rad,

Effects of betulinic acid alone and in combination with irradiation in human melanoma cells

in-vitro,

Melanoma,

TumCG↓, RadioS↑, Apoptosis↑, selectivity↑,

5586-

BetA,

Suppression of HIF-1α accumulation by betulinic acid through proteasome activation in hypoxic cervical cancer

in-vitro,

Cerv,

HeLa

Hif1a↓, VEGF↓, GLUT1↓, PDK1↓,

5585-

BetA,

Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response

in-vitro,

Cerv,

HeLa

in-vitro,

lymphoma,

U937

mtDam↑, TumAuto↑,

5584-

BetA,

Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors

in-vitro,

GBM,

A172

in-vitro,

GBM,

U118MG

in-vitro,

GBM,

U251

Apoptosis↑, P53↑, Cyt‑c↑, AIF↑, Casp↑, AntiTum↑, MMP↓,

5583-

BetA,

Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

vitro+vivo,

NA,

ROS↑, Bcl-2↓, BAX↑, TOP1↝, eff↝, toxicity↓, toxicity↓, selectivity↑,

943-

BetA,

Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

in-vivo,

NA,

mouse model

Glycolysis↓, lactateProd↓, GlucoseCon↓, ECAR↓, cMyc↓, LDHA↓, p‑PDK1↓, PDK1↓, Cav1↑, *Glycolysis↑, selectivity↑, OCR↓, OXPHOS↓,

BetA,

Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana

in-vitro,

PC,

HaCaT

in-vitro,

Pca,

PANC1

HH↓, Gli1↓, PTCH1↓, Bcl-2↓,

4273-

BetA,

Betulinic acid, a natural PDE inhibitor restores hippocampal cAMP/cGMP and BDNF, improve cerebral blood flow and recover memory deficits in permanent BCCAO induced vascular dementia in rats

in-vivo,

NA,

 (BCCAO) induced VaDin experimental rats

*neuroP↑, *BDNF↑, *ROS↓, *Inflam↓, *cognitive↑,

2722-

BetA,

Betulinic Acid for Cancer Treatment and Prevention

Review,

Var,

MMP↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, ROS↑, NF-kB↑, TOP1↓,

2723-

BetA,

Betulinic acid and oleanolic acid modulate CD81 expression and induce apoptosis in triple-negative breast cancer cells through ROS generation

in-vitro,

BC,

MDA-MB-231

Apoptosis↑, tumCV↓, ROS↑,

2718-

BetA,

The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis

in-vitro,

AML,

U937

TumCCA↑, Apoptosis↑, i-ROS↑, cycA1/CCNA1↓, CycB/CCNB1↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,

2721-

BetA,

Proteomic Investigation into Betulinic Acid-Induced Apoptosis of Human Cervical Cancer HeLa Cells

in-vitro,

Cerv,

HeLa

15 µmol/L, 30 µmol/L, 50 µmol/L) of BA for 24 h, 48 h, and 72 h.

30.42±2.39 µM

ROS↑, Dose↝, Bcl-2↓, BAX↑, ER Stress↑,

2720-

BetA,

Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo

in-vitro,

Cerv,

HeLa

Keap1↝, ROS↑, Ca+2↑, Beclin-1↓, GRP78/BiP↑, LC3II↑, p62↑, ERStress↑, TumAuto↑,

2719-

BetA,

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential

in-vitro,

CRC,

T24/HTB-9

30 μg/mL BA for 48 h

in-vitro,

Bladder,

UMUC3

33.2 μg/mL

in-vitro,

Bladder,

5637

 28.5 μg/mL

TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,

2734-

BetA,

Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer

in-vitro,

CRC,

HCT116

6.441 µg/mL (14.15 µM)

in-vitro,

CRC,

SW480

1.67 µg/mL (3.670 µM)

tumCV↓, HSP70/HSPA5⇅, ROS↑, cl‑Casp3↑, mt-Apoptosis↑, Dose↝,

2724-

BetA,

Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice

in-vivo,

Nor,

mice

in-vivo,

Stroke,

AntiTum↑, *Inflam↓, *ROS↓, *NOX4↓, *Apoptosis↓, neuroP↑,

2725-

BetA,

Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice

in-vivo,

Nor,

*RenoP↑, *SOD?, *Catalase↑, *GSH↑, *ROS↓, *MDA↓, *IL1β↓, *TNF-α↓, *IL10↓, *IL6↑, *NRF2↑,

2726-

BetA,

Betulinic acid induces DNA damage and apoptosis in SiHa cells

in-vitro,

Cerv,

SiHa

39.83 μg/ml

tumCV↓, DNAdam↑, MMP↓, ROS↑, TumCCA↑, TOP1↓,

2727-

BetA,

Betulinic acid in the treatment of breast cancer: Application and mechanism progress

Review,

BC,

mt-ROS↑, Sp1/3/4↓, TumMeta↓, GlucoseCon↓, NF-kB↓, ChemoSen↑, chemoP↑, m-Apoptosis↑, TOP1↓,

2728-

BetA,

Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy

in-vitro,

Var,

NF-kB↑, IKKα↑, eff↓,

2729-

BetA,

Betulinic acid in the treatment of tumour diseases: Application and research progress

Review,

Var,

ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, eff↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP↑, *toxicity↓,

2730-

BetA,

Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells

in-vitro,

Bladder,

T24/HTB-9

tumCV↓, TumCP↓, TumCMig↓, Casp↑, TumAuto↑, LC3B-II↑, p‑AMPK↑, mTOR↓, BMI1↓, ROS↑, eff↓,

2731-

BetA,

Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives

Review,

GBM,

Review,

Park,

Review,

AD,

BBB↑, *GSH↑, *Catalase↑, *motorD↑, *neuroP↑, *cognitive↑, *ROS↓, *antiOx↑, *Inflam↓, MMP↓, STAT3↓, NF-kB↓, Sp1/3/4↓, TOP1↓, EMT↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, BioAv↓,

2717-

BetA,

Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma

in-vitro,

Melanoma,

U266

10-40uM

in-vivo,

Melanoma,

Nude Mouse Xenograft Model

in-vitro,

Melanoma,

RPMI-8226

Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, NF-kB↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP1↑, MDA↑, SOD↓, SOD2↓, GCLM↓, GSTA1↓, FTH1↓, GSTs↓, TumVol↓,

2716-

BetA,

Cellular and molecular mechanisms underlying the potential of betulinic acid in cancer prevention and treatment

Review,

Var,

AntiCan↑, TumCD↑, TumCCA↑, ROS↑, NF-kB↓, Bcl-2↓, Half-Life↝, GLUT1↓, VEGF↓, PDK1↓,

2732-

BetA,

Chemo,

Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78

in-vitro,

BC,

MCF-7

18.411

in-vitro,

BC,

MDA-MB-231

20.465 μM

in-vitro,

Nor,

MCF10

ChemoSen↑, selectivity↑, GRP78/BiP↑, ER Stress↑, PERK↑, Ca+2↑, Cyt‑c↑, BAX↑, Bcl-2↓,

2733-

BetA,

Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling

in-vitro,

Oral,

12.5–100 μM BA for 24–72 h

in-vivo,

NA,

BA against OSCC in implanted mice in vivo

TumCP↓, TumVol↓, mt-Apoptosis↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↑, OCR↓, TumCCA↑, ROS↑, eff↓, P53↑, STAT3↓, cycD1/CCND1↑,

2735-

BetA,

Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications

Review,

Var,

mt-Apoptosis↑, Casp↑, p38↑, MAPK↓, JNK↓, VEGF↓, AIF↑, Cyt‑c↑, ROS↑, Ca+2↑, ATP↓, NF-kB↓, ATF3↓, TOP1↓, VEGF↓, survivin↓, Sp1/3/4↓, MMP↓, ChemoSen↑, selectivity↑, BioAv↓, BioAv↑, BioAv↑, BioAv↑, BioAv↑,

2736-

BetA,

Chemo,

Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis

Review,

Var,

chemoPv↑, p‑STAT3↓, JAK1↓, JAK2↓, VEGF↓, EGFR↓, Cyt‑c↑, Diablo↑, AMPK↑, mTOR↓, Sp1/3/4↓, DNAdam↑, Gli1↓, GLI2↓, PTCH1↓, MMP2↓, MMP9↓, miR-21↓, SOD2↓, ROS↑, Apoptosis↑,

2757-

BetA,

Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways

in-vitro,

GBM,

U251

tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, Ferroptosis↑, HO-1↑, NRF2↑,

2738-

BetA,

Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

BT549

in-vivo,

NA,

mice

TumCI↓, TumCMig↓, Glycolysis↓, lactateProd↓, GRP78/BiP↑, ER Stress↑, PERK↑, p‑eIF2α↑, β-catenin/ZEB1↓, cMyc↓, ROS↑, angioG↓, Sp1/3/4↓, DNAdam↑, TOP1↓, TumMeta↓, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, LDHA↓, p‑PDK1↓, PDK1↓, ECAR↓, OCR↓, Hif1a↓, STAT3↓,

2758-

BetA,

Betulinic Acid Attenuates Oxidative Stress in the Thymus Induced by Acute Exposure to T-2 Toxin via Regulation of the MAPK/Nrf2 Signaling Pathway

in-vivo,

Nor,

mice

*ROS↓, *MDA↓, *SOD↑, *GSH↑, *p‑p38↓, *p‑JNK↓, *p‑ERK↓, *NRF2↑, *HO-1↑, *MAPK↓, *heparanase↑, *antiOx↑,

2759-

BetA,

Chemopreventive and Chemotherapeutic Potential of Betulin and Betulinic Acid: Mechanistic Insights From In Vitro, In Vivo and Clinical Studies

Review,

Var,

chemoPv↑, ChemoSen↑, *Inflam↓, *NRF2↑, *NF-kB↓, *COX2↓, ROS↑, MMP↓, Sp1/3/4↓, VEGF↓,

2760-

BetA,

A Review on Preparation of Betulinic Acid and Its Biological Activities

Review,

Var,

Review,

Stroke,

AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1↓, MMP9↓, COX2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,

2761-

BetA,

Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans

in-vivo,

Nor,

Insulin↓, IGF-1↓, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *antiOx?,

2762-

BetA,

Targeting Effect of Betulinic Acid Liposome Modified by Hyaluronic Acid on Hepatoma Cells In Vitro

in-vitro,

Liver,

HepG2

ROCK1↓, RAS↓, *BioAv↓, BioAv↑,

2763-

BetA,

Betulinic Acid Inhibits the Stemness of Gastric Cancer Cells by Regulating the GRP78-TGF-β1 Signaling Pathway and Macrophage Polarization

in-vitro,

GC,

GRP78/BiP↓, TGF-β↓, ChemoSen↑, CSCs↓, SMAD2↓, SMAD3↓, OCT4↓,

Showing Research Papers: 1301 to 1350 of 5786
Prev Page 27 of 116 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5786

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

Sepsis↓, 1,
Total Targets: 173

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx?, 1, antiOx↑, 4, Catalase↑, 4, GSH↑, 5, HO-1↑, 1, MDA↓, 3, NOX4↓, 1, NRF2↑, 3, ROS↓, 8, SOD?, 1, SOD↑, 3,

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1, ALAT↓, 1, Glycolysis↑, 1, LDH↓, 1, LDL↓, 1,

Cell Death ⓘ

Apoptosis↓, 1, p‑JNK↓, 1, MAPK↓, 1, p‑p38↓, 1,

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,

Migration ⓘ

heparanase↑, 1, α-SMA↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, IL10↓, 1, IL1β↓, 1, IL6↑, 1, Inflam↓, 6, NF-kB↓, 1, TNF-α↓, 1,

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,

Clinical Biomarkers ⓘ

ALAT↓, 1, AST↓, 1, IL6↑, 1, LDH↓, 1,

Functional Outcomes ⓘ

cognitive↑, 2, hepatoP↑, 2, motorD↑, 1, MusCon↓, 1, neuroP↑, 2, RenoP↑, 2, toxicity↓, 2,
Total Targets: 43

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Cancer Database Query Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Immune & Inflammatory Signaling ⓘ

Synaptic & Neurotransmission ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

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