| Source: |
| Type: type of cell death |
| Situation in which a cell actively pursues a course toward death upon receiving certain stimuli. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. |
| 8053- | KAE, | Kaempferol as a therapeutic agent in Alzheimer's disease: Evidence from preclinical studies |
| - | Review, | AD, | NA |
| 8056- | KAE, | Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications |
| - | Review, | Var, | NA | - | Review, | Diabetic, | NA |
| 9063- | L-THE, | doxoR, | L-Theanine Ameliorates Doxorubicin-Induced Ovarian Toxicity by Reducing Endoplasmic Reticulum Stress |
| - | in-vivo, | Nor, | NA |
| 9007- | L-THE, | L-theanine's therapeutic effects on colorectal cancer: Mechanistic insights from a 1,2-dimethylhydrazine-induced rat model |
| - | in-vivo, | CRC, | NA |
| 9003- | L-THE, | L-Theanine Protects H9C2 Cells from Hydrogen Peroxide-Induced Apoptosis by Enhancing Antioxidant Capability |
| - | in-vitro, | Nor, | H9c2 |
| 8147- | Lae, | Mechanisms underlying the therapeutic effects of Amygdalin in treating Cervical Cancer based on multi-omics analysis |
| - | in-vitro, | Cerv, | Ca9-22 | - | in-vitro, | Cerv, | HeLa |
| 8148- | lamb, | Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells |
| - | in-vitro, | Pca, | LNCaP |
| 8161- | LapC, | Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells |
| - | in-vitro, | ESCC, | KYSE-30 | - | in-vitro, | ESCC, | KYSE450 | - | in-vitro, | ESCC, | KYSE-510 |
| 8162- | LapC, | Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2 |
| - | in-vitro, | Melanoma, | MEL526 | - | in-vitro, | Melanoma, | MEL697 | - | in-vitro, | Melanoma, | MEL103 |
| 8164- | LapC, | Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II |
| - | vitro+vivo, | GBM, | NA |
| 8175- | Las, | Lasiodin Inhibits Proliferation of Human Nasopharyngeal Carcinoma Cells by Simultaneous Modulation of the Apaf-1/Caspase, AKT/MAPK and COX-2/NF-κB Signaling Pathways |
| - | in-vitro, | NPC, | NA |
| 8176- | Las, | In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model |
| - | vitro+vivo, | BC, | NA |
| 8177- | Las, | Lasiokaurin Regulates PLK1 to Induce Breast Cancer Cell G2/M Phase Block and Apoptosis |
| - | vitro+vivo, | BC, | MDA-MB-231 |
| 8179- | Las, | Lasiokaurin suppresses hepatocellular carcinoma proliferation and induces apoptosis via the JAK2/STAT3 pathway |
| - | in-vitro, | HCC, | NA |
| 8249- | LCA, | Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells |
| - | in-vitro, | NSCLC, | NA |
| 8237- | LCA, | Role of Licochalcone A in Potential Pharmacological Therapy: A Review |
| - | Review, | Var, | NA |
| 8245- | LCA, | Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity |
| - | in-vivo, | LiverDam, | NA |
| 8244- | LCA, | Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest |
| - | in-vitro, | Liver, | HepG2 |
| 8243- | LCA, | Licochalcone A Inhibits Cellular Motility by Suppressing E-cadherin and MAPK Signaling in Breast Cancer |
| - | in-vitro, | BC, | MDA-MB-231 |
| 8241- | LCA, | Licochalcone A induces apoptotic cell death via JNK/p38 activation in human nasopharyngeal carcinoma cells |
| - | in-vitro, | NPC, | NA |
| 8238- | LCA, | Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6 |
| - | in-vitro, | BC, | MCF7 | - | in-vivo, | NA, | MCF10 |
| 8253- | LCA, | Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma |
| - | in-vitro, | SCC, | HSC4 |
| 8259- | LCA, | Modulation of bcl-2 and cytotoxicity by licochalcone-A, a novel estrogenic flavonoid |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | AML, | HL-60 |
| 8261- | LCA, | Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels |
| - | in-vitro, | CRC, | T24/HTB-9 |
| 8209- | LCA, | Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells |
| - | in-vitro, | Ovarian, | SKOV3 |
| 8208- | LCA, | Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells |
| - | in-vitro, | BC, | MCF7 |
| 8207- | LCA, | Licochalcone a Induces ROS-Mediated Apoptosis through TrxR1 Inactivation in Colorectal Cancer Cells |
| - | in-vitro, | CRC, | HCT116 |
| 8235- | LCA, | Anticancer effects of licochalcones: A review of the mechanisms |
| - | Review, | Var, | NA |
| 8229- | LCA, | Licochalcone A: a review of its pharmacology activities and molecular mechanisms |
| - | Review, | Nor, | NA |
| 8210- | LCA, | Licochalcone A-Induced Human Bladder Cancer T24 Cells Apoptosis Triggered by Mitochondria Dysfunction and Endoplasmic Reticulum Stress |
| - | in-vitro, | Bladder, | T24/HTB-9 |
| 8233- | LCA, | Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer |
| - | in-vitro, | Lung, | NA |
| 8232- | LCA, | Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study |
| - | vitro+vivo, | ESCC, | NA |
| 8211- | LCA, | Licochalcone A induces endoplasmic reticulum stress-mediated apoptosis of endometrial cancer cells via upregulation of GRP78 expression |
| - | in-vitro, | EC, | NA |
| 8231- | LCA, | Maintenance of the Expression of c-FLIPL by Hsp70 to Resist Licochalcone A-Induced Anti-Colorectal Cancer Effect through ERK-Mediated Autophagy Induction |
| - | in-vitro, | CRC, | NA |
| 8225- | LCA, | Cisplatin, | Licochalcone A protects against cisplatin-induced acute kidney injury via the modulation of Nrf2/Keap1-mediated ferroptosis and apoptosis |
| - | in-vivo, | Nor, | NA |
| 8223- | LCA, | Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells |
| - | in-vitro, | Nor, | RAW264.7 |
| 8341- | LDN, | Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy |
| - | Review, | Var, | NA |
| 8337- | LDN, | Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis by increasing M1-type macrophages and activating the Bax/Bcl-2/caspase-3/PARP pathway |
| - | in-vitro, | CRC, | NA |
| 8339- | LDN, | Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells in vitro and effects indirectly on tumor-associated macrophages in vivo |
| - | in-vivo, | Cerv, | HeLa |
| 8290- | LE, | Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells |
| - | vitro+vivo, | Pca, | DU145 |
| 8269- | LE, | Glycyrrhiza glabra-Enhanced Extract and Adriamycin Antiproliferative Effect on PC-3 Prostate Cancer Cells |
| - | in-vitro, | Pca, | PC3 |
| 8236- | LE, | Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects |
| - | Review, | Var, | NA |
| 8262- | LE, | Phytochemical profiling, antimicrobial, cytotoxic and apoptotic effects of Glycyrrhiza glabra ethanolic extract |
| - | in-vitro, | Liver, | HepG2 |
| 8265- | LE, | Glycyrrhizin ameliorates colorectal cancer progression by regulating NHEJ pathway through inhibiting HMGB1-induced DNA damage response |
| - | vitro+vivo, | CRC, | NA |
| 8282- | LE, | Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis |
| - | in-vitro, | GC, | MGC803 | - | in-vitro, | GC, | BGC-823 | - | in-vitro, | GC, | SGC-7901 |
| 8276- | LE, | Cisplatin, | Glycyrrhizin enhances the antitumor activity of cisplatin in non‑small cell lung cancer cells by influencing DNA damage and apoptosis |
| - | in-vitro, | NSCLC, | NA |
| 8278- | LE, | Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology |
| - | Review, | Var, | NA |
| 8279- | LE, | 18β-Glycyrrhetinic Acid Has Anti-Cancer Effects via Inducing Apoptosis and G2/M Cell Cycle Arrest, and Inhibiting Migration of A549 Lung Cancer Cells |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Lung, | H23 | - | in-vitro, | Lung, | H460 |
| 8281- | LE, | A Licorice Roots Extract Induces Apoptosis and Cell Cycle Arrest and Improves Metabolism via Regulating MiRNAs in Liver Cancer Cells |
| - | in-vitro, | Liver, | NA |
| 1306- | LE, | Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell |
| - | in-vitro, | BC, | MCF7 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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