| Source: |
| Type: type of cell death |
| Situation in which a cell actively pursues a course toward death upon receiving certain stimuli. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. |
| 8145- | LF, | Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 8130- | LF, | Lactoferrin targeting INTL1 receptor inhibits hepatocellular carcinoma progression via apoptosis and cell cycle signaling pathways |
| - | in-vitro, | HCC, | HepG2 | - | in-vitro, | HCC, | HepG3 | - | in-vitro, | HCC, | SK-HEP-1 |
| 8132- | LF, | Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase |
| - | in-vitro, | BC, | HS587T | - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | T47D | - | in-vitro, | BC, | MCF10 |
| 8134- | LF, | Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways |
| - | in-vitro, | CRC, | HT-29 |
| 8135- | LF, | Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 8199- | LGE, | Citral is a new inducer of caspase-3 in tumor cell lines |
| - | in-vitro, | Var, | NA |
| 8193- | LGE, | Targets and pathways involved in the antitumor activity of citral and its stereo-isomers |
| - | Review, | Var, | NA |
| 8192- | LGE, | Essential Oils of Lemongrass (Cymbopogon citratus Stapf) Induces Apoptosis and Cell Cycle Arrest in A549 Lung Cancer Cells |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Lung, | H1975 |
| 8189- | LGE, | Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects |
| - | vitro+vivo, | CRC, | NA |
| 8188- | LGE, | Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells |
| - | in-vitro, | BC, | MCF7 |
| 8187- | LGE, | Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation |
| - | in-vitro, | BC, | 4T1 | - | in-vitro, | Ovarian, | OVCAR-3 | - | in-vitro, | Ovarian, | SKOV3 |
| 8292- | lign, | Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives |
| - | Review, | Var, | NA |
| 8299- | lign, | Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer |
| - | Trial, | BC, | NA |
| 8333- | LIN, | Linalool preferentially induces robust apoptosis of a variety of leukemia cells via upregulating p53 and cyclin-dependent kinase inhibitors |
| - | in-vitro, | AML, | NA |
| 8330- | LIN, | SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death |
| - | in-vitro, | GBM, | U87MG |
| 8325- | LIN, | Validating linalool as a potential drug for breast cancer treatment based on machine learning and molecular docking |
| - | in-vitro, | BC, | NA |
| 8321- | LIN, | doxoR, | Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells |
| - | in-vitro, | BC, | MCF7 |
| 8320- | LIN, | Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways |
| - | in-vivo, | Nor, | NA |
| - | in-vitro, | Oral, | OECM-1 | - | in-vitro, | Nor, | FR-2 |
| 8317- | LIN, | Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways |
| - | in-vitro, | Liver, | HepG2 |
| 6484- | LIN, | Linalool Inhibits MCF-7 Tumor Growth in a Xenograft Model by Apoptosis Induction and Immune Modulation |
| - | vitro+vivo, | BC, | MCF7 |
| 6479- | LIN, | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer |
| - | in-vivo, | Colon, | HCT116 |
| 6481- | LIN, | Linalool inhibits 22Rv1 prostate cancer cell proliferation and induces apoptosis |
| - | in-vivo, | Pca, | 22Rv1 |
| 6483- | LIN, | Linalool-Incorporated Nanoparticles as a Novel Anticancer Agent for Epithelial Ovarian Carcinoma |
| - | in-vitro, | Ovarian, | A2780S |
| 7825- | LT, | MBS, | Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review |
| - | Review, | AD, | NA |
| 8375- | LT, | Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches |
| - | Review, | Var, | NA |
| 8395- | LT, | PacT, | Luteolin enhances drug chemosensitivity by downregulating the FAK/PI3K/AKT pathway in paclitaxel‑resistant esophageal squamous cell carcinoma |
| - | in-vitro, | ESCC, | NA |
| 8379- | LT, | Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | Stroke, | NA |
| 8377- | LT, | Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases |
| - | Review, | Asthma, | NA |
| 8384- | LT, | Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors |
| - | Review, | GC, | NA |
| 8387- | LT, | QC, | Api, | Ba, | Identification of Flavonoid Compounds in Treating Alzheimer's Disease Based on Network Medicine Framework Strategy |
| - | in-vitro, | AD, | NA |
| 8389- | LT, | Luteolin-Manganese Nanozyme Induces Apoptosis and Ferroptosis for Enhanced Cancer Therapy |
| - | in-vitro, | Var, | NA |
| 8390- | LT, | Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective |
| - | Review, | IBD, | NA | - | Review, | CRC, | NA |
| 8391- | LT, | Mechanism of luteolin against non-small-cell lung cancer: a study based on network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments |
| - | in-vitro, | NSCLC, | NA |
| 8403- | LT, | Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells |
| - | in-vitro, | CRC, | HT-29 |
| 8400- | LT, | Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling |
| - | in-vitro, | BC, | NA |
| - | in-vivo, | AD, | NA |
| 8397- | LT, | Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules |
| - | Review, | Var, | NA |
| 8367- | LT, | Role of Luteolin in Prevention of Oral, Esophageal, Gastric, Pancreatic, and Colon Cancers: Recent Trends and Future Perspectives |
| - | Review, | Var, | NA |
| 8368- | LT, | A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells |
| - | in-vitro, | Lung, | NA |
| 8371- | LT, | Study on the regulatory mechanism of luteolin inhibiting WDR72 on the proliferation and metastasis of non small cell lung cancer |
| - | vitro+vivo, | Lung, | A549 | - | in-vitro, | Lung, | H1299 | - | in-vitro, | Nor, | BEAS-2B |
| 8372- | LT, | Luteolin targets peroxiredoxin 2 to augment T-cell-mediated cytotoxicity and suppress lung adenocarcinoma progression |
| - | in-vitro, | Lung, | NA |
| 1317- | LT, | Luteolin Suppresses Teratoma Cell Growth and Induces Cell Apoptosis via Inhibiting Bcl-2 |
| - | vitro+vivo, | Ovarian, | PA1 |
| 1171- | LT, | The inhibition of β-catenin activity by luteolin isolated from Paulownia flowers leads to growth arrest and apoptosis in cholangiocarcinoma |
| - | in-vitro, | CCA, | NA |
| - | in-vitro, | Nor, | MCF10 | - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MDA-MB-468 | - | in-vitro, | PC, | Bxpc-3 |
| 1025- | LT, | Api, | Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer |
| - | in-vivo, | Lung, | NA |
| 1100- | LT, | Luteolin, a flavonoid, as an anticancer agent: A review |
| - | Review, | Var, | NA |
| 973- | LT, | Luteolin impairs hypoxia adaptation and progression in human breast and colon cancer cells |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | BC, | MDA-MB-231 |
| 2925- | LT, | Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3 |
| - | in-vitro, | Cerv, | HeLa | - | in-vitro, | Nor, | HEK293 | - | in-vitro, | BC, | MCF7 |
| 2923- | LT, | Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells |
| - | in-vitro, | neuroblastoma, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:14 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid