eff Cancer Research Results

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2135- TQ,    Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
- in-vitro, Nor, HaCaT
*HO-1↑, *NRF2↑, *e-ERK↑, *e-Akt↑, *AMPKα↑, *ROS⇅, *eff↓, *tumCV∅,
2095- TQ,    Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis
- Review, Var, NA
TumCCA↑, Apoptosis↑, ROS↑, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, cl‑PARP↑, P53↑, P21↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, eff↑,
2096- TQ,    Effect of total hydroalcholic extract of Nigella sativa and its n-hexane and ethyl acetate fractions on ACHN and GP-293 cell lines
- in-vitro, Nor, GP-293 - in-vitro, Kidney, ACHN
selectivity↑, eff↝,
2098- TQ,    Anticancer activity of Nigella sativa (black seed) and its relationship with the thermal processing and quinone composition of the seed
- in-vitro, Colon, MC38 - in-vitro, lymphoma, L428
NF-kB↓, eff↑, eff↓,
2101- TQ,    HDAC inhibition by Nigella sativa L. sprouts extract in hepatocellular carcinoma: an approach to study anti-cancer potential
- Study, HCC, NA
HDAC↓, eff↑, eff↑, AntiCan↑,
2104- TQ,    The Potential Role of Nigella sativa Seed Oil as Epigenetic Therapy of Cancer
- in-vitro, BC, MCF7 - in-vitro, Cerv, HeLa
TumCP↓, Apoptosis↑, UHRF1↓, DNMT1↓, HDAC1↓, eff↝,
2106- TQ,    Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy
- Review, Var, NA
Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,
1929- TQ,    Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells
- in-vitro, Bladder, 5637 - in-vitro, Bladder, T24/HTB-9
tumCV↓, TumCP↓, TumCI↓, Casp↑, ROS↑, PD-L1↓, EMT↓, MMP↓, eff↓,
1931- TQ,  doxoR,    Thymoquinone enhances the anticancer activity of doxorubicin against adult T-cell leukemia in vitro and in vivo through ROS-dependent mechanisms
- in-vivo, AML, NA
eff↑, tumCV↓, TumCCA↑, ROS↑, MMP↓, eff↑, TumVol↓, eff↑, Ki-67↓,
1933- TQ,    Thymoquinone: potential cure for inflammatory disorders and cancer
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCCA↑, ROS↑, angioG↓, Apoptosis↑, Casp↑, eff↑, eff↝,
1934- TQ,    Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species
- in-vitro, Pca, PC3 - in-vitro, Pca, C4-2B
ROS↑, GSH↓, eff↓, AR↓,
2454- Trip,    Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
- in-vitro, HNSCC, HaCaT - in-vivo, NA, NA
GSDME-N↑, Pyro↑, cMyc↓, HK2↓, BAD↑, BAX↑, Casp3↑, NRF2↓, xCT↓, ROS↑, eff↑, Glycolysis↓, GlucoseCon↓, lactateProd↓, ATP↓, xCT↓, eff↑,
2412- TTT,    A review of tumor treating fields (TTFields): advancements in clinical applications and mechanistic insights
- Review, GBM, NA
TumCG↓, eff↝, OS↑,
6459- TUR,    Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis
- in-vivo, Nor, NA - in-vivo, Colon, NA
*NO?, eff↑, eff↑, AntiTum↑, *Inflam↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
5017- UA,    Ursolic acid disturbs ROS homeostasis and regulates survival-associated gene expression to induce apoptosis in intestinal cancer cells
- in-vitro, Cerv, INT-407 - in-vitro, CRC, HCT116
AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, TumCMig↓, CTNNB1↓, Twist↓, Bcl-2↓, survivin↓, NF-kB↓, Sp1/3/4↓, BAX↑, P21↑, P53↑, eff↓, TumCMig↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4861- Uro,    Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, *Aβ↓, *toxicity↓, *BBB↑, *p‑tau↓, *eff↓, *IL1α↓, *MCP1↓, *MIP‑1α↓, *TNF-α↓, *IL2↓, *SIRT1↓, *DNAdam↓, *Dose↝, *Strength↑, *motorD↑, *CTSZ↓,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *eff↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *eff↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4834- Uro,    Urolithin A increases the natural killer activity of PBMCs in patients with prostate cancer
- Human, Pca, NA
eff↑, NK cell↑,
4842- Uro,    Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, MCF7 - in-vitro, BC, 4T1
Inflam↓, IL6↓, TNF-α↓, eff↑, STAT3↓, TumCP↓, TumCMig↓,
4843- Uro,    The effects of urolithins on the response of prostate cancer cells to non-steroidal antiandrogen bicalutamide
- in-vitro, Pca, LNCaP
TumCP↓, eff↑, ChemoSen↝,
6412- Uro,  EGCG,    A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease
- in-vivo, AD, NA
*Aβ↓, *eff↑, *cognitive↑, *neuroG↑, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *p‑tau↓, *FIS1↓, *ATP↑, *lipid-P↓,
4312- VitB1/Thiamine,    Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease
- Review, AD, NA
*eff↑, *cognitive↑, *memory↑, *GlucoseCon↑, *Aβ↓, *Inflam↓, *antiOx↑, *p‑tau↓, *AGEs↓, *Dose↝,
4049- VitB1/Thiamine,    Vitamin B1 (thiamine) and dementia
- Review, AD, NA
*memory↑, *p‑tau↓, *cognitive↑, *Dose↝, *Dose↓, *Aβ↓, *other↝, *eff↑, *eff↑,
1888- VitB1/Thiamine,  DCA,    High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate
- in-vitro, PC, SK-N-BE - NA, PC, PANC1
p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,
4043- VitB12,  FA,    Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment
- Trial, AD, NA
*other↑, *other↑, *eff↝, *homoC↓, *cognitive↑,
4033- VitB3,    Can nicotinamide riboside protect against cognitive impairment?
- in-vivo, AD, NA
*memory↑, *DNAdam↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *BACE↓, *Aβ↓, *BBB↑, *GutMicro↑, *eff↑,
4326- VitB5,    Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease
- in-vivo, HD, NA
*Risk↓, *neuroP↑, *other?, *Ach↑, *other↝, *eff↓, *other↝,
4052- VitB6,    B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study
- Study, AD, NA
*neuroP↑, *other↑, *other↑, *cognitive↑, *eff↝, *Risk↑, *other↑,
1836- VitC,  VitK3,  Chemo,    Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib
- in-vitro, AML, NA
tumCV↓, selectivity↑, Apoptosis↑, eff↑, ChemoSen↑,
3136- VitC,    Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
- in-vitro, Colon, SW48 - in-vitro, Colon, LoVo
ERK↓, p‑PKM2↓, GLUT1↓, Warburg↓, TumCD↑, eff↑, ROS↓, cMyc↓,
3138- VitC,    The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity
- in-vitro, RCC, RCC4 - in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-435 - in-vitro, Ovarian, SKOV3 - in-vitro, Colon, SW48 - in-vitro, GBM, U251
eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,
3139- VitC,    Vitamin C and sodium bicarbonate enhance the antioxidant ability of H9C2 cells and induce HSPs to relieve heat stress
- in-vitro, Nor, H9c2
*Apoptosis∅, *LDH∅, *MDA∅, *SOD↓, eff↝,
3140- VitC,    Vitamin-C-dependent downregulation of the citrate metabolism pathway potentiates pancreatic ductal adenocarcinoma growth arrest
- in-vitro, PC, MIA PaCa-2 - in-vitro, Nor, HEK293
citrate↓, FASN↓, ACLY↓, LDH↓, Glycolysis↓, Warburg↓, PDK1↓, GLUT1↓, LDHA↓, ECAR↓, PDH↑, eff↑,
3141- VitC,    High-dose Vitamin C inhibits PD-L1 expression by activating AMPK in colorectal cancer
- in-vitro, CRC, HCT116
Glycolysis↓, eff↑, PD-L1↓, AMPK↑, HK2↓, NF-kB↓, Warburg↓, tumCV↓, GLUT1↓, PKM2↓, LDHA↓, CD4+↑, CD8+↑,
3143- VitC,  ATO,    Vitamin C enhances the sensitivity of osteosarcoma to arsenic trioxide via inhibiting aerobic glycolysis
- in-vitro, OS, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Glycolysis↓, lactateProd↓, ATP↓, PGK1↓, PGM1↓, LDHA↓,
3148- VitC,    Antioxidants in brain tumors: current therapeutic significance and future prospects
- Review, Var, NA
*antiOx↑, *ROS↓, chemoPv↑, ChemoSen↑, TET2↑, eff↑, OS↑, QoL↑, eff↑,
3153- VitC,    Vitamin C Status and Cognitive Function: A Systematic Review
- Review, AD, NA
cognitive↑, eff↑,
3107- VitC,    Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment
- Review, Var, NA
Risk↓, *ROS↓, ROS↑, VEGF↓, COX2↓, ER Stress↑, IRE1↑, JNK↑, CHOP↑, Hif1a↓, eff↑, Glycolysis↓, MMPs↓, TumMeta↓, YAP/TEAD↓, eff↑, TET1↑,
3114- VitC,    Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
- in-vitro, AML, NA
TET2↑, eff↑, ROS↑, Fenton↑, Hif1a↓,
3117- VitC,    Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
- in-vitro, Nor, mESC
TET1↑, eff↝,
3121- VitC,  immuno,    Ascorbic acid induced TET2 enzyme activation enhances cancer immunotherapy efficacy in renal cell carcinoma
- in-vivo, RCC, A498 - in-vitro, RCC, 786-O
TET2↑, eff↑, eff↑,
3129- VitC,    Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis
- in-vivo, Stroke, NA
*BBB↑, *MMP9↓, *MMPs↓, *MMP2↓, *CLDN1↝, *ZO-1↝, eff↑,
4468- VitC,  SSE,    Selenium modulates cancer cell response to pharmacologic ascorbate
- in-vivo, GBM, U87MG - in-vitro, CRC, HCT116
eff↓, TumCD↑, ChemoSen↑, ROS⇅, DNAdam↑, PARP↑, NAD↓, Glycolysis↓, Fenton↑, lipid-P↑, eff↓, H2O2↑, other↝,
4086- VitD3,    The beneficial role of vitamin D in Alzheimer's disease
- Review, AD, NA
*Mood↑, *cognitive↑, *eff↑,
1739- VitD3,    Effect of Vitamin D3 Supplements on Development of Advanced Cancer
- Trial, Var, NA
AntiCan↑, Dose↝, Risk↓, TumCP↓, Inflam↓, eff∅,

Showing Research Papers: 1351 to 1400 of 1426
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1426

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Fenton↑, 2,   GSH↓, 2,   H2O2↑, 2,   lipid-P↑, 2,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 12,   ROS⇅, 1,   ROS∅, 1,   i-ROS↑, 1,   xCT↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 3,   MMP↓, 6,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMPK↑, 1,   citrate↓, 1,   cMyc↓, 3,   cMyc↑, 1,   ECAR↓, 1,   FASN↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 6,   HK2↓, 2,   lactateProd↓, 3,   LDH↓, 1,   LDHA↓, 3,   NAD↓, 1,   PDH↑, 1,   p‑PDH↓, 1,   PDK1↓, 1,   PDKs↓, 1,   PGK1↓, 1,   PGM1↓, 1,   PKM2↓, 1,   p‑PKM2↓, 1,   SIRT1↑, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 9,   BAD↑, 1,   BAX↑, 6,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Bcl-xL↓, 1,   Casp↑, 3,   Casp3↑, 4,   cl‑Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 2,   GSDME-N↑, 1,   hTERT/TERT↓, 1,   IAP1↓, 1,   IAP2↓, 1,   JNK↑, 1,   MAPK↑, 1,   necrosis↑, 1,   p38↑, 1,   Pyro↑, 1,   survivin↓, 3,   TumCD↑, 2,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↑, 1,   ER Stress↑, 1,   IRE1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 4,   DNMT1↓, 1,   P53↑, 4,   PARP↑, 3,   cl‑PARP↑, 2,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 2,   P21↑, 2,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CTNNB1↓, 1,   EMT↓, 2,   ERK↓, 2,   FOXO1↑, 1,   GSK‐3β↑, 1,   HDAC↓, 1,   HDAC1↓, 1,   PI3K↓, 1,   PI3K↑, 1,   STAT3↓, 1,   p‑STAT3↓, 1,   TumCG↓, 4,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   E-cadherin↑, 1,   Ki-67↓, 1,   MMP2↓, 2,   MMP9↓, 3,   MMPs↓, 1,   N-cadherin↓, 1,   PKCδ↓, 1,   Snail↓, 1,   TET1↑, 2,   TumCI↓, 3,   TumCMig↓, 6,   TumCP↓, 9,   TumMeta↓, 2,   Twist↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Hif1a↓, 2,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2↓, 3,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 3,   NF-kB↓, 5,   NK cell↑, 2,   PD-L1↓, 2,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 7,   ChemoSen↝, 1,   Dose↝, 2,   Dose∅, 1,   eff↓, 9,   eff↑, 34,   eff↝, 6,   eff∅, 1,   RadioS↑, 2,   selectivity↑, 4,   TET2↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   GutMicro↑, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   Ki-67↓, 1,   LDH↓, 1,   PD-L1↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 4,   AntiTum↑, 2,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   OS↑, 2,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity↑, 1,   TumVol↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 166

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 4,   Catalase↑, 4,   Ferroptosis↓, 1,   GPx↑, 5,   GSH↑, 2,   GSR↑, 1,   GSTA1↓, 1,   GSTs↑, 1,   H2O2↓, 2,   HDL↑, 1,   HO-1↑, 3,   lipid-P↓, 5,   MDA↓, 1,   MDA∅, 1,   NADH↓, 1,   NRF2↑, 4,   PARK2↑, 2,   RNS↓, 1,   ROS↓, 8,   ROS⇅, 1,   SOD↓, 1,   SOD↑, 6,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2,   FIS1↓, 1,   MMP↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   GlucoseCon↑, 1,   homoC↓, 1,   LDH∅, 1,   LDL↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   e-Akt↑, 1,   Apoptosis↓, 2,   Apoptosis∅, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Ferroptosis↓, 1,   MAPK↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other?, 1,   other↓, 1,   other↑, 6,   other↝, 3,   tumCV∅, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

e-ERK↑, 1,   mTOR↓, 1,   neuroG↑, 2,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Cartilage↑, 2,   CLDN1↝, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   ZO-1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO?, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 5,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 2,   CRP↓, 1,   CTSZ↓, 1,   IL1α↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL6↓, 4,   Imm↑, 1,   Inflam↓, 9,   MCP1↓, 1,   MIP‑1α↓, 1,   NF-kB↓, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,   MAOA↓, 1,   p‑tau↓, 6,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 7,   BACE↓, 1,   NLRP3↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 1,   Dose↓, 1,   Dose↝, 4,   eff↓, 3,   eff↑, 10,   eff↝, 2,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   CRP↓, 1,   GutMicro↑, 3,   IL6↓, 4,   LDH∅, 1,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 3,   cognitive↑, 9,   memory↑, 5,   Mood↑, 1,   motorD↑, 2,   neuroP↑, 6,   Obesity↓, 1,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 3,   Risk↑, 1,   Strength↑, 3,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 125

Scientific Paper Hit Count for: eff, efficacy
69 Silver-NanoParticles
58 Magnetic Fields
49 Curcumin
43 Sulforaphane (mainly Broccoli)
35 Vitamin C (Ascorbic Acid)
32 Thymoquinone
32 Chemotherapy
29 immunotherapy
28 Shikonin
26 chitosan
26 EGCG (Epigallocatechin Gallate)
25 Piperlongumine
24 Artemisinin
24 Quercetin
23 Resveratrol
23 Selenium NanoParticles
23 Selenite (Sodium)
22 Copper and Cu NanoParticles
22 Baicalein
21 Dichloroacetate
20 Radiotherapy/Radiation
20 Ashwagandha(Withaferin A)
20 Berberine
18 Chlorogenic acid
18 Capsaicin
18 Chrysin
18 Magnetic Field Rotating
17 Apigenin (mainly Parsley)
17 Phenylbutyrate
16 Metformin
16 diet FMD Fasting Mimicking Diet
16 Gambogic Acid
16 Bicarbonate(Sodium)
15 Selenium
15 Lycopene
14 Citric Acid
14 Propolis -bee glue
14 Exercise
14 Phenethyl isothiocyanate
13 3-bromopyruvate
13 Caffeic acid
12 Cisplatin
12 Betulinic acid
12 Disulfiram
12 Fisetin
11 Folic Acid, Vit B9
11 Auranofin
11 Melatonin
11 borneol
11 doxorubicin
11 salinomycin
11 Dandelion Root
11 Rosmarinic acid
10 Alpha-Lipoic-Acid
10 Luteolin
10 Atorvastatin
10 Boron
10 Choline
10 Vitamin K2
10 Silymarin (Milk Thistle) silibinin
10 diet Methionine-Restricted Diet
10 Honokiol
10 VitK3,menadione
10 Urolithin
9 Coenzyme Q10
9 Gold NanoParticles
9 SonoDynamic Therapy UltraSound
9 Vitamin D3
9 Ellagic acid
9 Carvacrol
9 Electrical Pulses
9 Eugenol
9 Hydrogen Gas
8 Photodynamic Therapy
8 Hyperthermia
8 Chlorophyllin
8 Docosahexaenoic Acid
8 Plumbagin
8 Parthenolide
7 5-fluorouracil
7 Docetaxel
7 Carnosic acid
7 Piperine
6 Vitamin B12
6 Fenbendazole
6 Allicin (mainly Garlic)
6 Dipyridamole
6 beta-glucans
6 Bifidobacterium
6 Celastrol
6 Diclofenac
6 HydroxyCitric Acid
6 Spermidine
6 Juglone
6 Terpinen-4-ol / Tea Tree Oil
5 1,8-Cineole
5 Astragalus
5 chemodynamic therapy
5 Akkermansia
5 Bevacizumab (brand Avastin)
5 Gemcitabine (Gemzar)
5 Aspirin
5 Ascorbyl Palmitate
5 Astaxanthin
5 Berbamine
5 beta-carotene(VitA)
5 Bortezomib
5 Boswellia (frankincense)
5 Thymol-Thymus vulgaris
5 Centella asiatica / Gotu kola → asiaticoside
5 diet Plant based
5 Echinacea
5 MCToil
5 Magnolol
5 Moringa oleifera
5 Nimbolide
4 2-DeoxyGlucose
4 cetuximab
4 almonertinib
4 Andrographis
4 α-Bisabolol / Chamomile oil
4 Butyrate
4 capecitabine
4 Cat’s Claw
4 Cannabidiol
4 CUSP9
4 erastin
4 diet Short Term Fasting
4 Propyl gallate
4 Pterostilbene
4 Sulfasalazine
4 Whole Body Vibration
3 Anthocyanins
3 Zinc
3 Anti-oxidants
3 Aloe anthraquinones
3 D-limonene
3 Biochanin A
3 Beta-Caryophyllene
3 bempedoic acid
3 Lutein
3 Zeaxanthin
3 Bufalin/Huachansu
3 temozolomide
3 hydroxychloroquine
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Calorie Restriction Mimetics
3 Cysteamine
3 Ginseng
3 Lecithin
3 nicotinamide adenine dinucleotide
3 Naringin
3 Radio Frequency
3 Taurine
3 Vitamin B1/Thiamine
2 5-Aminolevulinic acid
2 Glucose
2 Anethole/trans-Anethole
2 Vitamin A, Retinoic Acid
2 Aromatherapy
2 Sorafenib (brand name Nexavar)
2 Trastuzumab
2 Arsenic trioxide
2 Baicalin
2 brusatol
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Rutin
2 Caffeine
2 Calcium
2 carboplatin
2 Celecoxib
2 Cinnamon
2 Hydroxycinnamic-acid
2 Crocetin
2 Cucurbitacin
2 Cyclopamine
2 Dichloroacetophenone(2,2-)
2 Dasatinib/Phyrago
2 Deguelin
2 Date Fruit Extract
2 Oxygen, Hyperbaric
2 Emodin
2 ferumoxytol
2 Kaempferol
2 Genistein (soy isoflavone)
2 γ-linolenic acid (Borage Oil)
2 Orlistat
2 Potassium
2 Methylene blue
2 metronomic chemo
2 Methylsulfonylmethane
2 Mushroom Lion’s Mane
2 Niclosamide (Niclocide)
2 Phosphatidylserine
2 Aflavin-3,3′-digallate
2 tetrathiomolybdate
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 Trichostatin A
1 wortmannin
1 Resiquimod
1 EMF
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Amodiaquine
1 DTS(dibenzyl trisulphide) from Anamu
1 Fennel Oil/Foeniculum vulgare
1 Huperzine A/Huperzia serrata
1 probiotics
1 Brucea javanica
1 Bacopa monnieri
1 Bromelain
1 Bruteridin(bergamot juice)
1 urea
1 Carnosine
1 Cannabichromene
1 Beta‐Lapachone
1 Carica papaya leaf extract
1 Camptothecin
1 irinotecan
1 Carvone
1 Black phosphorus
1 gefitinib, erlotinib
1 eicosapentaenoic acid
1 Dihydrocaffeic Acid
1 diet Fermented Foods
1 diet Ketogenic
1 Mistletoe
1 Lemongrass Extract/Citral
1 PXD, phenoxodiol
1 Eurycomanone
1 Ferulic acid
1 Vitamin E
1 flavonoids
1 Flickering Light Stimulation
1 verapamil
1 Garcinol
1 Geraniol
1 tamoxifen
1 HydroxyTyrosol
1 itraconazole
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Linalool
1 Matrine
1 Methyl Jasmonate
1 methotrexate
1 Magnesium
1 Methylglyoxal
1 Mushroom Reishi
1 Myricetin
1 No Product/Mechanism Only
1 Oleocanthal
1 Peppermint
1 sericin
1 Paclitaxel
1 Psoralidin
1 enzalutamide
1 Oxaliplatin
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 acetaminophen
1 Formononetin
1 acetazolamide
1 Iron
1 Squalene
1 Glutathione
1 statins
1 Sutherlandioside D
1 triptolide
1 Tumor Treating Fields
1 Turmerones
1 Ursolic acid
1 Vitamin B3,Niacin
1 Vitamin B5,Pantothenic Acid
1 Vitamin B6,pyridoxine
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:961  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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