ERK Cancer Research Results

ERK, ERK signaling: Click to Expand ⟱
Source:
Type:
MAPK3 (ERK1)
ERK proteins are kinases that activate other proteins by adding a phosphate group. An overactivation of these proteins causes the cell cycle to stop.
The extracellular signal-regulated kinase (ERK) signaling pathway is a crucial component of the mitogen-activated protein kinase (MAPK) signaling cascade, which plays a significant role in regulating various cellular processes, including proliferation, differentiation, and survival. high levels of phosphorylated ERK (p-ERK) in tumor samples may indicate active ERK signaling and could correlate with aggressive tumor behavior

EEk singaling is frequently activated and is often associated with aggressive tumor behavior, treatment resistance, and poor outcomes.
Scientific Papers found: Click to Expand⟱
6017- CGA,    Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
- Review, Var, NA
AntiCan↑, *chemoP↑, TNF-α↓, COX2/PTGS2↓, IL6↓, eff↑, PD-L1↓, *cognitive↓, *Aβ↓, *TAC↑, *SOD↑, *eff↑, *eff↑, ChemoSen↑, tumCV↓, Apoptosis↑, ERK↓, chemoP↑, *GPx↑, *GSTs↑, *GSH↑, *SOD↑, *Catalase↑, *ROS↓, *lipid-P↓, *MDA↓, *Casp3↓, *HO-1↓, cardioP↑, radioP↑,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2/PTGS2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6026- CGA,    Chlorogenic Acid: The Conceivable Chemosensitizer Leading to Cancer Growth Suppression
- Review, Var, NA
ChemoSen↑, AMPK↑, EGFR↓, PI3K↓, mTOR↓, Hif1a↓, VEGF↓, MAPK↓, ERK↓, DNAdam↑, TOP1↓, TOP2↓, Apoptosis↑, *BioAv↝, *Half-Life↓,
7182- CHA,    Chaetocin inhibits IBMX-induced melanogenesis in B16F10 mouse melanoma cells through activation of ERK
- in-vitro, Melanoma, B16-BL6
Mel↓, tyrosinase↓, MITF↓, ERK↑,
6066- CHL,    The chlorophyllin-induced cell cycle arrest and apoptosis in human breast cancer MCF-7 cells is associated with ERK deactivation and Cyclin D1 depletion
- in-vitro, BC, MCF7
ERK↓, Bcl-2↓, Apoptosis↑,
6127- CHr,    Chrysin Inhibits Tumor Promoter-Induced MMP-9 Expression by Blocking AP-1 via Suppression of ERK and JNK Pathways in Gastric Cancer Cells
- in-vitro, GC, AGS
AP-1↓, p‑cJun↓, p‑cFos↓, JNK↓, ERK↓, MMP9↓, TumCI↓,
2590- CHr,    Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway
- in-vitro, GBM, T98G - in-vitro, GBM, U251 - in-vitro, GBM, U87MG
TumCP↓, TumCMig↓, TumCI↓, NRF2↓, HO-1↓, NADPH↓, ERK↓,
2795- CHr,    Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53
- in-vitro, Liver, HepG2
ChemoSen↑, P53↑, ERK↑, BAX↑, DR5↑, Bcl-2↓, Casp8↑, Cyt‑c↑, Casp9↑,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2791- CHr,    Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction
- in-vitro, Ovarian, OV90
TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,
6162- Cin,    Anticancer Potential and Molecular Mechanisms of Cinnamaldehyde and Its Congeners Present in the Cinnamon Plant
- Review, Var, NA
AntiCan↑, Apoptosis↑, ROS↑, BAX↑, Cyt‑c↑, Fas↑, Casp9↑, E-cadherin↑, Casp7↑, PARP↑, Bak↑, AMPK↑, Ca+2↑, BAD↑, MMP↓, cycA1/CCNA1↓, CycB/CCNB1↓, ERK↓, VEGF↓, TumCP↓, MAPK↓, mTOR↓, PI3K↓, PCNA↓, Bcl-2↓, TumCCA↑, angioG↓, *ROS↓, Inflam↓,
1587- Citrate,    ATP citrate lyase: A central metabolic enzyme in cancer
- Review, NA, NA
ACLY↓, other↓, PFK1↓, ATP↓, PFK2↓, Mcl-1↓, Casp3↑, Casp2↑, Casp9↑, IGF-1R↓, PI3K↓, Akt↓, p‑Akt↓, p‑ERK↓, PTEN↑, Snail↓, E-cadherin↑, ChemoSen↑,
4764- CoQ10,  VitE,    Auxiliary effect of trolox on coenzyme Q10 restricts angiogenesis and proliferation of retinoblastoma cells via the ERK/Akt pathway
- in-vitro, RPE, Y79 - in-vitro, Nor, ARPE-19 - in-vivo, NA, NA
tumCV↓, Apoptosis↑, ROS↑, MMP↓, TumCCA↑, VEGF↓, ERK↓, Akt↓, ChemoSen↑, chemoP↑, toxicity↓, angioG↓,
6181- Cro,    Crocetin: A Systematic Review
- Review, Var, NA - Review, AD, NA
cardioP↑, hepatoP↑, *neuroP↑, AntiCan↑, *AntiDiabetic↑, *memory↑, *BioAv↓, *ROS↓, Apoptosis↑, *lipid-P↓, *SOD↑, SOD↓, ERα/ESR1↓, HDAC2↓, TumCCA↑, Bax:Bcl2↑, IL6↓, IL8↓, Shh↓, COX2/PTGS2↑, *GSK‐3β↓, *ERK↓, *tau↓, *ROS↓, *GSTs↑, *Catalase↑, *SOD↑, *BioAv↑,
6309- Cro,    Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway
- in-vitro, CRC, HCT116
tumCV↓, TumCP↓, Ki-67↓, Apoptosis↓, Inflam↓, ROS↑, MMP↓, JAK2↓, STAT3↓, ERK↓, MIP2↓, IL6↓, MCP1/CCL2↓, IL8↓, IL1β↓, TNF-α↓, SOD↓, Catalase↓, GSH↓, ROS↑, mtDam↑,
6183- Cu,    Copper(II) oxide nanoparticles penetrate into HepG2 cells, exert cytotoxicity via oxidative stress and induce pro-inflammatory response
- in-vitro, Liver, HepG2
ROS↑, MAPK↑, ERK↑, AP-1↑,
6195- Cuc,    Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
- Review, Var, NA
TumCG↓, Apoptosis↑, TumCCA↑, TumMeta↓, angioG↓, chemoPv↑, BioAv↓, Half-Life↝, cycD1/CCND1↓, cycE/CCNE↓, Casp3↑, cl‑PARP↑, JNK↑, Akt↓, ERK↓, survivin↓, XIAP↓, Bcl-2↓, Mcl-1↓, ROS↑, NRF2↓, FAK↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, *NF-kB↓, TLR4↝, NLRP3↑, Pyro↑, GSH↓,
6202- Cuc,    Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms
- Review, Var, NA
*Inflam↓, *antiOx↑, *hepatoP↑, AntiTum↑, AntiCan↑, *chemoPv↑, *AntiDiabetic↑, *Imm↑, Hif1a↓, P-gp/ABCB1↓, mTORC1↓, ERK↓, Akt↓, Casp3↑, Casp7↑, ATP↓, RadioS↑, ChemoSen↑,
2821- CUR,    Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)
- Review, Var, NA
*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP/DDIT3↑,
2979- CUR,  GB,    Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death
- in-vitro, Lung, H157 - in-vitro, Lung, H1299
EGFR↓, Sp1/3/4↓, ERK↓, MEK↓, Akt↓, S6K↓,
4175- CUR,    Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress
- in-vivo, NA, NA
*BDNF↑, *ERK↑,
1980- CUR,  Rad,    Thioredoxin reductase-1 (TxnRd1) mediates curcumin-induced radiosensitization of squamous carcinoma cells
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
selectivity↑, RadioS↑, TrxR↓, ROS↑, ERK↑, Dose∅, cl‑PARP↑,
473- CUR,    Curcumin inhibits epithelial-mesenchymal transition in oral cancer cells via c-Met blockade
- in-vitro, Oral, HSC4 - in-vitro, Oral, Ca9-22
Vim↓, p‑cMET↓, p‑ERK↓, pro‑MMP9↓, E-cadherin↑,
463- CUR,    Curcumin induces autophagic cell death in human thyroid cancer cells
- in-vitro, Thyroid, K1 - in-vitro, Thyroid, FTC-133 - in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, 8505C
TumAuto↑, LC3II↑, Beclin-1↑, p‑p38↑, p‑JNK↑, p‑ERK↑, p62↓, p‑PDK1↓, p‑Akt↓, p‑p70S6↓, p‑PIK3R1↓, p‑S6↓, p‑4E-BP1↓,
462- CUR,    Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress
- in-vitro, Pca, PC3
Bcl-2↓, MMP↓, cl‑Casp3↑, BAX↑, BIM↑, p‑PARP↑, PUMA↑, p‑P53↑, ROS↑, p‑ERK↑, p‑eIF2α↑, CHOP/DDIT3↑, ATF4↑,
485- CUR,  PDT,    Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin
- in-vitro, Melanoma, NA
NF-kB↓, Casp8↑, Casp9↑, p‑Akt↓, p‑ERK↓,
437- CUR,    Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids
- vitro+vivo, CRC, TCO1 - vitro+vivo, CRC, TCO2
cycD1/CCND1↓, cMyc↓, p‑ERK↓, CD44↓, CD133↓, LGR5↓, TumCCA↑, TumVol↓, CSCs↓,
144- CUR,  Bical,    Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C
- in-vitro, Pca, PC3 - in-vitro, PC, DU145 - in-vitro, PC, LNCaP
p‑ERK↑, p‑JNK↓, MUC1↓, p65↓, AR↓, TumCG↓, MEK↑, SAPK↑,
155- CUR,    Osteopontin and MMP9: Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate Cancer Cells
- in-vitro, Pca, PC3
p‑ERK↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, angioS↑,
159- CUR,    Crosstalk from survival to necrotic death coexists in DU-145 cells by curcumin treatment
- in-vitro, Pca, DU145
ROS↑, p‑Jun↑, p‑p38↑, TumAuto↑, Casp8↑, Casp9↑, Akt↓, ERK↓, p38↓,
6720- CUR,  SFN,  DHCA,    Synergistic Combinations of Curcumin, Sulforaphane, and Dihydrocaffeic Acid against Human Colon Cancer Cells
- in-vitro, Colon, HT29 - in-vitro, Colon, Caco-2 - in-vitro, Nor, FHC
selectivity↑, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, ROS⇅, ERK↑, JNK↑, MAPK↑, P21↑, cycD1/CCND1↓, Cyt‑c↑,
7451- CYN,    Inhibitory effects of cynaropicrin on human melanoma progression by targeting MAPK, NF‐κB, and Nrf‐2 signaling pathways in vitro
- in-vitro, Melanoma, A375
TumCP↓, Casp3↑, Apoptosis↑, TumCMig↓, TumCI↓, ERK↓, NF-kB↓, ROS↓, HO-1↑, NRF2↑, Bcl-2↓, NF-kB↓, other↝,
7444- CYN,    The Sesquiterpene Lactone Cynaropicrin Manifests Strong Cytotoxicity in Glioblastoma Cells U-87 MG by Induction of Oxidative Stress
- in-vitro, GBM, U87MG
TumCG↓, Dose↝, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, TumAuto↑, p‑ERK↓, NF-kB↓, ChemoSen↑, eff↓,
7437- CYN,    Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma
- in-vitro, Mye, AMO1 - in-vivo, Mye, NA - in-vitro, Mye, KMS11 - in-vitro, Mye, JJN3 - in-vitro, Mye, MolP8 - in-vitro, Mye, L363 - in-vitro, Mye, H929
tumCV↓, cMyc↓, STAT3↓, Akt↓, ERK↓, TumCCA↑, DNAdam↑, PARP1↑, AIF↑, TumCG↓,
1443- Deg,    Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, BT549
EGFR↓, Akt↓, p‑ERK↓, NF-kB↓, p‑STAT3↓, survivin↓, Myc↓, TumCG↓, cMET↓,
1446- Deg,    Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells
- in-vitro, BC, 4T1
cMET↓, p‑ERK↓, p‑Akt↓, TumCMig↓, TumCG↓, Weight∅, *toxicity∅, Hif1a↓, TumMeta↓,
1109- DHA,    DHA inhibits Gremlin-1-induced epithelial-to-mesenchymal transition via ERK suppression in human breast cancer cells
- in-vitro, BC, NA
GREM1↓, TumCMig↓, p‑ERK↓, EMT↓,
6736- Dipy,    Nucleoside Transport Inhibition by Dipyridamole Prevents Angiogenesis Impairment by Homocysteine and Adenosine
*other↝, *p‑MEK↑, *ERK↑, *angioG↑,
6343- DRE,    Dandelion root extract affects ESCC progression via regulating multiple signal pathways
- vitro+vivo, ESCC, NA
*Inflam↓, TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↓, TumCG↓, PI3K↓, p‑Akt↓, RAS↓, Raf↓, p‑ERK↓, Bcl-2↓, BAX↑,
6348- DRE,    New prospects in oncotherapy: bioactive compounds from Taraxacum officinale
- Review, Var, NA
Dose↝, TumCP↓, toxicity↓, *AntiDiabetic↑, *antiOx↑, *hepatoP↑, *diuretic↑, *Inflam↓, *neuroP↑, *Imm↑, eff↑, Apoptosis↑, tumCV↓, selectivity↑, TumCMig↓, EMT↓, MMP2↓, MMP9↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, JNK↓, ERK↓,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
7220- EGb 761,    Ginkgo Biloba Extract Inhibits Metastasis and ERK/Nuclear Factor kappa B (NF-κB) Signaling Pathway in Gastric Cancer
- vitro+vivo, GC, SGC-7901
TumCP↓, TumCMig↓, TumCI↓, p‑ERK↓, NF-kB↓, MMP2↓, eff↑, TumCG↓, TumMeta↓, Dose↝, TumVol↓,
1303- EGCG,    (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation
- in-vitro, EC, NA
TumCP↓, ER-α36↓, cycD1/CCND1↓, ERK↑, Jun↓, BAX↑, Bcl-2↓, cl‑Casp3↑, ROS↑, p38↑,
670- EGCG,    Epigallocatechin-3-gallate and its nanoformulation in cervical cancer therapy: the role of genes, MicroRNA and DNA methylation patterns
- Review, NA, NA
TumCCA↑, P53↑, ERK↓, EGFR↓, p‑ERK↑, VEGF↓, Hif1a↓, miR-203↓, miR-210↑,
649- EGCG,  CUR,  PI,    Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
*BioEnh↑, EGFR↓, HER2/EBBR2↓, IGF-1↓, MAPK↓, ERK↓, RAS↓, Raf↓, NF-kB↓, p‑pRB↓, TumCCA↑, Glycolysis↓, Warburg↓, HK2↓, Pyruv↓,
692- EGCG,    EGCG: The antioxidant powerhouse in lung cancer management and chemotherapy enhancement
- Review, NA, NA
ROS↑, Apoptosis↑, DNAdam↑, CTR1↑, JWA↑, β-catenin/ZEB1↓, P53↑, Vim↓, VEGF↓, p‑Akt↓, Hif1a↓, COX2/PTGS2↓, ERK↓, NF-kB↓, Akt↓, Bcl-xL↓, miR-210↓,
691- EGCG,    Preclinical Pharmacological Activities of Epigallocatechin-3-gallate in Signaling Pathways: An Update on Cancer
- Review, NA, NA
Apoptosis↑, necrosis↑, TumAuto↑, ERK↓, p38↓, NF-kB↓, VEGF↓,
680- EGCG,    Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
- Review, NA, NA
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27/CDKN1B↑, P21↑,
682- EGCG,    Suppressive Effects of EGCG on Cervical Cancer
- Review, NA, NA
E7↓, E6↓, PI3K/Akt↓, P53↑, p27/CDKN1B↑, P21↑, CDK2↓, mTOR↓, HIF-1↓, IGF-1↓, EGFR↓, ERK↓, VEGF↓,
2992- EGCG,    Effects of Epigallocatechin-3-Gallate on Matrix Metalloproteinases in Terms of Its Anticancer Activity
- Review, Var, NA
AP-1↓, Sp1/3/4↓, NF-kB↓, ERK↓, P-gp/ABCB1↓, HSP27↓, β-catenin/ZEB1↓, MMPs↓, TNF-α↓, IL1β↓, MMP2↓,

Showing Research Papers: 101 to 150 of 374
Prev Page 3 of 8 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 374

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

Mel↓, 1,   MITF↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   Catalase↓, 1,   Fenton↑, 1,   GSH↓, 3,   HO-1↓, 3,   HO-1↑, 2,   HO-2↓, 1,   Iron↑, 1,   lipid-P↑, 1,   NRF2↓, 3,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 17,   ROS⇅, 1,   SOD↓, 2,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 2,   MEK↓, 1,   MEK↑, 1,   MMP↓, 8,   MMP↑, 1,   mtDam↑, 2,   Raf↓, 2,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   ALAT↓, 1,   AMPK↑, 2,   cMyc↓, 3,   ECAR↝, 1,   GlucoseCon↓, 1,   Glycolysis↓, 3,   HK2↓, 2,   lactateProd↓, 1,   LDH↓, 1,   LDL↓, 1,   NADPH↓, 1,   PDK1?, 2,   PDK1↓, 1,   p‑PDK1↓, 1,   PFK1↓, 1,   PFK2↓, 1,   PI3K/Akt↓, 1,   p‑PIK3R1↓, 1,   PPARα↓, 1,   Pyruv↓, 1,   p‑S6↓, 1,   S6K↓, 1,   SIRT1↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 13,   Akt↑, 1,   p‑Akt↓, 7,   p‑Akt↑, 1,   Apoptosis↓, 2,   Apoptosis↑, 14,   BAD↑, 1,   Bak↑, 1,   BAX↑, 7,   Bax:Bcl2↑, 2,   Bcl-2↓, 10,   Bcl-xL↓, 3,   BIM↑, 1,   Casp↑, 1,   Casp2↑, 1,   Casp3↑, 6,   cl‑Casp3↑, 2,   Casp7↑, 2,   Casp8↑, 3,   Casp9↑, 6,   Cyt‑c↑, 7,   Diablo↑, 1,   DR5↑, 1,   Fas↑, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 1,   iNOS↓, 2,   JNK↓, 2,   JNK↑, 4,   p‑JNK↓, 1,   p‑JNK↑, 2,   JWA↑, 1,   MAPK↓, 4,   MAPK↑, 4,   Mcl-1↓, 4,   MDM2↓, 1,   Myc↓, 2,   necrosis↑, 1,   NOXA↑, 1,   p27/CDKN1B↑, 2,   p38↓, 2,   p38↑, 2,   p‑p38↑, 2,   PUMA↑, 2,   Pyro↑, 1,   survivin↓, 3,   Telomerase↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   Sp1/3/4↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↓, 1,   other↓, 1,   other↝, 1,   p‑pRB↓, 1,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 2,   p‑eIF2α↑, 2,   ER Stress↑, 2,   GRP78/BiP↑, 1,   HSP27↓, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 5,   P53↑, 6,   p‑P53↑, 1,   PARP↑, 3,   p‑PARP↑, 1,   cl‑PARP↑, 3,   PARP1↑, 1,   PCNA↓, 3,   SAPK↑, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 6,   cycE/CCNE↓, 2,   P21↑, 5,   p‑RB1↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   CD133↓, 1,   CD44↓, 2,   CDK8↓, 1,   p‑cFos↓, 1,   cMET↓, 2,   p‑cMET↓, 1,   CSCs↓, 2,   EMT↓, 3,   ERK↓, 23,   ERK↑, 6,   p‑ERK↓, 12,   p‑ERK↑, 6,   GREM1↓, 1,   HDAC↓, 1,   HDAC2↓, 1,   IGF-1↓, 2,   IGF-1R↓, 1,   Jun↓, 1,   p‑Jun↑, 1,   LGR5↓, 1,   mTOR↓, 5,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↑, 1,   OCT4↓, 1,   PI3K↓, 6,   PI3K↑, 1,   PTEN↑, 2,   RAS↓, 2,   Shh↓, 1,   SOX2↓, 1,   STAT3↓, 5,   p‑STAT3↓, 2,   TOP1↓, 2,   TOP2↓, 1,   TumCG↓, 9,   tyrosinase↓, 1,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AP-1↑, 1,   Ca+2↑, 3,   Ca+2↝, 1,   CLDN1↓, 1,   E-cadherin↑, 4,   ER-α36↓, 1,   FAK↓, 1,   p‑FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 2,   miR-203↓, 1,   MMP-10↓, 1,   MMP2↓, 6,   MMP9↓, 6,   pro‑MMP9↓, 1,   MMPs↓, 1,   MUC1↓, 1,   PKCδ↓, 1,   Slug↓, 1,   SMAD3↓, 1,   Snail↓, 3,   TET1↑, 1,   TGF-β↓, 1,   TumCI↓, 6,   TumCMig↓, 8,   TumCP↓, 11,   TumMeta↓, 3,   Twist↓, 2,   Vim↓, 3,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   angioS↑, 1,   ATF4↑, 1,   EGFR↓, 8,   Endoglin↑, 1,   HIF-1↓, 1,   Hif1a↓, 7,   miR-210↓, 1,   miR-210↑, 1,   VEGF↓, 11,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CTR1↑, 1,   NHE1↓, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 3,   COX2/PTGS2↑, 2,   IL10↓, 1,   IL1β↓, 3,   IL6↓, 4,   IL8↓, 2,   Inflam↓, 3,   JAK↓, 1,   JAK2↓, 1,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 12,   p65↓, 1,   PD-L1↓, 2,   PGE2↓, 1,   TLR4↓, 1,   TLR4↝, 1,   TNF-α↓, 4,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 2,   ERα/ESR1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 7,   Dose↝, 4,   Dose∅, 2,   eff↓, 1,   eff↑, 7,   Half-Life↝, 1,   RadioS↑, 4,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 8,   ERα/ESR1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 4,   Ki-67↓, 2,   LDH↓, 1,   Myc↓, 2,   PD-L1↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 2,   cardioP↑, 3,   chemoP↑, 3,   chemoPv↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 2,   TumVol↓, 2,   Weight∅, 1,  
Total Targets: 286

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

diuretic↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↑, 3,   GPx↑, 2,   GSH↑, 2,   GSTs↑, 2,   HDL↑, 1,   HO-1↓, 2,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 2,   NRF2↑, 2,   ROS↓, 6,   SOD↑, 5,   SOD1↑, 1,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

p‑MEK↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↝, 1,   GLUT2↑, 1,   HMG-CoA↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 2,   Casp9↓, 1,   Fas↓, 1,   HGF/c-Met↑, 1,   iNOS↓, 2,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   ERK↑, 2,   p‑ERK↑, 1,   GSK‐3β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1β↓, 1,   Imm↑, 2,   Inflam↓, 5,   NF-kB↓, 3,   TLR4↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 2,   BioEnh↑, 1,   eff↑, 2,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 3,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↓, 1,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 3,   RenoP↑, 1,   toxicity∅, 1,  
Total Targets: 62

Scientific Paper Hit Count for: ERK, ERK signaling
16 Berberine
16 Curcumin
15 Fisetin
14 Quercetin
13 Sulforaphane (mainly Broccoli)
12 Silymarin (Milk Thistle) silibinin
11 Shikonin
10 EGCG (Epigallocatechin Gallate)
10 Magnetic Fields
9 Apigenin (mainly Parsley)
9 Thymoquinone
8 Baicalein
7 Artemisinin
7 Caffeic acid
7 Formononetin
6 Luteolin
6 Propolis -bee glue
6 Honokiol
6 Isobavachalcone
6 Lycopene
5 Alpha-Lipoic-Acid
5 Radiotherapy/Radiation
5 Chrysin
5 Piperine
5 Resveratrol
4 Silver-NanoParticles
4 Allicin (mainly Garlic)
4 Astaxanthin
4 Carvacrol
4 Emodin
4 Fucoidan
4 Garcinol
4 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
4 isoorientin
4 Rosmarinic acid
4 Vitamin K2
3 Cisplatin
3 Berbamine
3 Boswellia (frankincense)
3 Chlorogenic acid
3 Cynaropicrin
3 Ferulic acid
3 Hyperoside
3 Inositol
3 Phenethyl isothiocyanate
3 Piperlongumine
3 Ursolic acid
3 Vitamin C (Ascorbic Acid)
2 Andrographis
2 Ashwagandha(Withaferin A)
2 beta-glucans
2 Beta-Caryophyllene
2 Betulinic acid
2 Bromelain
2 Boron
2 Zinc
2 Capsaicin
2 Thymol-Thymus vulgaris
2 chaetocin
2 Crocetin
2 Cucurbitacin
2 Deguelin
2 Dandelion Root
2 Paclitaxel/Taxol
2 Gambogic Acid
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Ginkgetin
2 isoquercitrin
2 Kaempferol
2 Magnetic Field Rotating
2 Myricetin
2 Nimbolide
2 Phenylbutyrate
2 Pterostilbene
2 Sanguinarine
2 Salvia miltiorrhiza
2 Urolithin
2 Vitexin
1 1,8-Cineole
1 Camptothecin
1 alpha Linolenic acid
1 Anethole/trans-Anethole
1 Ascorbyl Palmitate
1 Trastuzumab
1 Baicalin
1 Biochanin A
1 Bacopa monnieri
1 brusatol
1 α-Bisabolol / Chamomile oil
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorophyllin
1 Cinnamon
1 Citric Acid
1 Coenzyme Q10
1 Vitamin E
1 Copper and Cu NanoParticles
1 gefitinib, erlotinib
1 Photodynamic Therapy
1 Bicalutamide
1 Dihydrocaffeic Acid
1 Docosahexaenoic Acid
1 Dipyridamole
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 eicosapentaenoic acid
1 Evodiamine
1 flavonoids
1 Metformin
1 5-fluorouracil
1 Gallic acid
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Ginseng
1 Graviola
1 Grapeseed extract
1 Hydrogen Gas
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 Huperzine A/Huperzia serrata
1 Isoliquiritigenin
1 Morin
1 Mung Bean Sprouts
1 Magnolol
1 Methyl salicylate / Sweet Birch oil
1 Naringin
1 Niclosamide (Niclocide)
1 Oleocanthal
1 Oxygen, Hyperbaric
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Plumbagin
1 Salvia officinalis
1 Aromatherapy
1 Aflavin-3,3′-digallate
1 Tomatine
1 Turmerones
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:105  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page