neuroP Cancer Research Results

neuroP, neuroprotective: Click to Expand ⟱
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Neuroprotective refers to the ability of a substance, intervention, or strategy to preserve the structure and function of nerve cells (neurons) against injury or degeneration.
-While cancer and neurodegenerative processes might seem distinct, there is significant overlap in terms of treatment-related neurotoxicity, shared molecular mechanisms, and the potential for therapies that provide neuroprotection during cancer treatment.
Scientific Papers found: Click to Expand⟱
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
4272- Bor,    Neuroprotective properties of borax against aluminum hydroxide-induced neurotoxicity: Possible role of Nrf-2/BDNF/AChE pathways in fish brain
*NRF2↑, *ROS↓, *antiOx↑, *lipid-P↑, *Inflam↓, *DNAdam↓, *BDNF↑, *neuroP↑, *GSH↑,
3866- Bos,    Mechanistic role of boswellic acids in Alzheimer's disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Ach↑, *NRF2↑, *NF-kB↓, *Aβ↓,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
5744- Buty,  PacT,    Oral sodium butyrate supplementation ameliorates paclitaxel-induced behavioral and intestinal dysfunction
- in-vivo, Var, NA
chemoP↑, neuroP↑, Inflam↓, GutMicro↑, *ROS↓, Dose↝,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
4265- CA,    Potential applications of nanomedicine for treating Parkinson's disease
- Review, Park, NA
*NRF2↑, *ARE↑, *neuroP↑, *motorD↑, *cognitive↑, *SOD↑, *GSR↑, *NGF↑, *BDNF↑,
3784- CA,  CGA,    Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer’s Disease and Some Pro-oxidant Induced Oxidative Stress in Rats’ Brain-In Vitro
- Study, AD, NA
*AChE↓, *BChE↓, *eff↑, *ROS↓, *neuroP↑,
5756- CA,    Experimental Evidence of Caffeic Acid’s Neuroprotective Activity in Alzheimer’s Disease: In Vitro, In Vivo, and Delivery-Based Insights
- vitro+vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *AChE↓, *BChE↓, *cognitive↑, *ROS↓, *Aβ↓, *tau↓, eff↑,
5864- CA,    Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
- vitro+vivo, Stroke, PC12
*neuroP↑, *GSH↑, *HO-1↑, *NQO1↑, *NRF2↑, *ARE↑, *ROS↓, *BBB↑,
5872- CA,    Nrf2/ARE-Mediated Antioxidant Actions of Pro-Electrophilic Drugs
- Review, Nor, NA
*NRF2↑, *GSH↑, *neuroP↑, *Inflam↓, *cardioP↑, *Obesity↓, *angioG↓, chemoP↑, *NF-kB↓,
5860- CAP,    Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *memory↑, *Pain↓, *TRPV1↑, *Aβ↓, *tau↓, *cognitive↑, *Risk↓, *motorD↓, *ROS↓, *TNF-α↓, *IL1β↓, *eff↑, *Risk↓,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5854- CAP,    Pharmacological activity of capsaicin: Mechanisms and controversies (Review)
- Review, Var, NA - Review, AD, NA
Obesity↓, Half-Life↓, antiOx↑, TRPV1↑, STAT3↓, Ca+2↑, ROS↑, MMP↓, *neuroP↑, *tau↓, *Inflam↓, *ROS?,
3854- CAP,    Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
- in-vivo, AD, NA
*Aβ↓, *cognitive↑, *APP↓, *MMP-10↝, *p‑tau↓, *Inflam↓, *neuroP↑, *Risk↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *PPARα↑,
3855- CAP,    Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
- in-vivo, AD, NA
*Risk↓, *Aβ↓, *p‑tau↓, *Inflam↓, *neuroP↑, *cognitive↑, *ADAM10↑, *PPARα↑,
5768- CAPE,    Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*antiOx↑, *Inflam↑, *AntiCan↑, *NRF2↑, *GSK‐3β↑, *Akt↑, *PI3K↑, *ROS↓, *SOD↑, *GSH↑, *MDA↓, *tau↓, *neuroP↑, *memory↑, *AChE↓, *other↝, *lipid-P↓,
5763- CAPE,    Synthesis and Biological Evaluation of a Caffeic Acid Phenethyl Ester Derivatives as Anti-Hepatocellular Carcinoma Agents via Inhibition of Mitochondrial Respiration and Disruption of Cellular Metabolism
- NA, HCC, NA
*antiOx↑, *neuroP↑, NF-kB↓, TumCG↓, TumMeta↓, MMPs↓, P53↑, ChemoSen↑,
5885- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, toxicity↓, *Inflam↓, AntiDiabetic↑, cardioP↑, neuroP↑, selectivity↑, Apoptosis↑, p‑Cofilin↑, F-actin↓, PI3K↓, Akt↓, MEK↓, MAPK↓,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2↓, *Dose↝,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2↓, *MDA↓,
5901- CAR,    Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement
- Review, Stroke, NA
*neuroP↑, *ROS↓, *MDA↓, *4-HNE↓, *SOD↑, *Catalase↑, *GPx↑, *Apoptosis↓, *cl‑Casp3↓, *TRPM7⇅, *BBB↓, *TRPM7↓,
5900- CAR,  TV,    Lights and Shadows of Essential Oil-Derived Compounds: Antimicrobial and Anti-Inflammatory Properties of Eugenol, Thymol, Cinnamaldehyde, and Carvacrol
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *cardioP↑, *neuroP↑, *NADPH↓, *NRF2↑, *HO-1↑, *IL1β↓, *TNF-α↓,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, BioAv↝, BioAv↑,
5927- CAR,    Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *motorD↑, *toxicity↓, *TRPV3↑, *other↓, *antiOx↑, *LDL↓, *COX2↓, *PPARα↑, *NO↓, *AChE↓, *eff↑, *SOD↑, *Catalase↑, *neuroP↑, *BioAv↝, *BBB↑, *BioAv↑,
5926- CAR,    An Updated Review of Research into Carvacrol and Its Biological Activities
- Review, Nor, NA - Review, AD, NA - Review, asthmatic, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *toxicity↓, *Pain↓, *TRPV3↑, *NRF2↑, *Ca+2↑, *ATP↑, *5LO↓, *COX2↓, PGE2↓, *hepatoP↑, *AntiAg↑, *Diar↓, *cardioP↑, *other↝, *chemoPv↑, *cognitive↑, *AChE↓, *GastroP↑, *eff↑, *BChE↓, *CRP↓,
5925- CAR,    Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
3876- Carno,  Ex,    Swimming exercise versus L-carnosine supplementation for Alzheimer’s dementia in rats: implication of circulating and hippocampal FNDC5/irisin
- in-vivo, AD, NA
*cognitive↑, *neuroP↑,
3878- Carno,    Safety and Efficacy Evaluation of Carnosine, An Endogenous Neuroprotective Agent for Ischemic Stroke
- in-vivo, Stroke, NA
*toxicity∅, *antiOx↑, *neuroP↑, *IronCh↑, *ROS↓,
3872- Carno,    Carnosine Protects Macrophages against the Toxicity of Aβ1-42 Oligomers by Decreasing Oxidative Stress
- in-vitro, AD, NA
*antiOx↑, *Inflam↓, *Aβ↓, *neuroP↑, *ROS↓, *NO↓,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *eff↑, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2↓, NF-kB↓,
5952- Cela,    Celastrol attenuates Alzheimer’s disease-mediated learning and memory impairment by inhibiting endoplasmic reticulum stress-induced inflammation and oxidative stress
- in-vivo, AD, NA
*memory↑, *Inflam↓, *ROS↓, *ER Stress↓, *neuroP↑, *Dose↝, *MDA↓, *SOD↑, *Catalase↑, *Aβ↓, BACE↓, LRP1↑, RAGE↓,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
6018- CGA,    Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems
- Review, Var, NA - Review, RCC, NA
*BioAv↓, *Inflam↓, *TNF-α↓, *NO↓, *COX2↓, *PGE2↓, *NF-kB↓, *IL6↓, *IL1β↓, *TLR2↓, *MAPK↓, *NRF2↓, *HO-1↑, *NQO1↑, *cardioP↑, *neuroP↑, *SOD↑, *GSH↑, *ROS↓, *LDH↓, *MDA↓, *cognitive↑, *eff↑,
6016- CGA,    Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
antiOx↑, *Bacteria↓, AntiCan↑, *Inflam↓, *cardioP↑, *AntiDiabetic↑, *GutMicro↑, *eff↑, *eff↑, *ROS↓, *IronCh↑, *neuroP↑, *AChE↓, *BChE↓, *chemoPv↑, *BioAv⇅,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *eff↑, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6008- CGA,    Risk Assessment of Chlorogenic and Isochlorogenic Acids in Coffee By-Products
- Review, Nor, NA
*toxicity↓, *antiOx↑, *Bacteria↓, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *cardioP↑, *BP↓, *other↓, eff↓,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6011- CGA,    Chlorogenic Acid’s Role in Metabolic Health: Mechanisms and Therapeutic Potential
- Review, Nor, NA
*BioAv↓, *antiOx↑, *Inflam↓, *Bacteria↓, *hepatoP↑, *cardioP↑, *neuroP↑, *ROS↓, *NF-kB↓, *NRF2↑, *Obesity↓, *GutMicro↑, *AntiAg↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *OCLN↓, *VEGF↓, BioAv↝,
6038- CGA,    Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices
- in-vivo, AD, NA - in-vivo, Stroke, NA
*eff↑, *other↓, *Risk↓, *cognitive↑, *neuroP↑, *antiOx↑,
6040- CGA,    Protective effect of chlorogenic acid on cognitive impairment in rats with early Alzheimer's disease via Wnt signaling pathway
- in-vivo, AD, NA
*neuroP↑, *Dose↝, *GSK‐3β↓, *tau↓, *β-catenin/ZEB1↑, *Wnt↑, *memory↑, *cognitive↑, *NRF2↑, *ROS↓,
6045- CGA,  SeNPs,    A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice
- in-vivo, AD, NA
*neuroP↑, *BioAv↑, *GutMicro↑, *BBB↑, *Aβ↓, *glucose↝,
6034- CGA,    Effect and mechanism of chlorogenic acid on cognitive dysfunction in mice by lipopolysaccharide-induced neuroinflammation
- in-vivo, AD, NA
*cognitive↑, *TNF-α↓, *antiOx↑, *Inflam↓, *neuroP↑, *BBB↑, *eff↑, *memory↑, *AKT1↓, *MMP9↓, *MAPK↓,
6033- CGA,  CA,    Comparative study on the inhibitory effect of caffeic and chlorogenic acids on key enzymes linked to Alzheimer's disease and some pro-oxidant induced oxidative stress in rats' brain-in vitro
- in-vivo, AD, NA
*AChE↓, *BChE↓, *eff↑, *eff↑, *neuroP↑,
6032- CGA,    Protective Effects of Chlorogenic Acid Against Amyloid-Beta-Induced Oxidative Stress and Ion Transport Dysfunction in SH-SY5Y Cells
- in-vitro, AD, NA
*CRM↑, *neuroP↑, *AChE↓,
6023- CGA,    Pharmacological advances of the chlorogenic acids family: current insights and future research directions
- Review, AD, NA - Review, Park, NA - Review, IBD, NA
*Aβ↓, *neuroP↑, *cardioP↑, *GastroP↑, *RenoP↑, *hepatoP↑, *Obesity↓, *Bacteria↓, *BioAv↑, *BioAv↑, *BioAv↑, *ROS↓, *GutMicro↑, *IBI↑, *MCT1↓, *NF-kB↓, *DNMT1↓,
6001- Chit,    Recent advances in engineering chitosan-based nanoplatforms in biotherapeutic multi-delivery for multi-targeted disease treatments: Promises and outlooks
- Review, Var, HepG2 - Review, AD, NA
TumVol↓, toxicity↓, Half-Life↑, eff↑, selectivity↑, Dose↝, *BDNF↑, *NRF2↑, *ROS↓, *neuroP↑, *memory↑, *cognitive↑, *Obesity↓,

Showing Research Papers: 101 to 150 of 518
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 518

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   HO-1↑, 2,   NADH↓, 1,   NRF2↑, 1,   Prx↓, 1,   PrxII↓, 1,   ROS↑, 9,  

Mitochondria & Bioenergetics ⓘ

ETC↓, 1,   MEK↓, 1,   mitResp↓, 1,   MMP↓, 5,   MPT↑, 1,   mtDam↑, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   cMyc↓, 1,   Glycolysis↓, 3,   PIK3CA↓, 1,   SIRT1↓, 1,   TCA↓, 1,  

Cell Death ⓘ

Akt↓, 4,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 8,   BAD↑, 1,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp↑, 3,   Casp3↑, 3,   Casp8↑, 1,   Casp9↑, 3,   Cyt‑c↑, 4,   Fas↑, 1,   FasL↑, 2,   JNK↑, 4,   MAPK↓, 3,   MAPK↑, 1,   p38↑, 1,   TRPV1↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,   HSP90↓, 2,  

Autophagy & Lysosomes ⓘ

BNIP3↝, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 3,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   Cyc↓, 1,   cycD1/CCND1↓, 3,   P21↑, 3,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   CSCs↓, 1,   EMT↝, 1,   ERK↓, 3,   Gli1↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   IGF-1↓, 1,   mTOR↓, 2,   Nanog↓, 1,   NOTCH↓, 2,   OCT4↓, 1,   PI3K↓, 5,   Smo↓, 1,   SOX2↓, 1,   STAT3↓, 2,   TOP1↓, 1,   TOP2↓, 1,   TRPM7↓, 2,   TumCG↓, 4,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

5LO↓, 1,   Ca+2↑, 1,   p‑Cofilin↑, 1,   E-cadherin↑, 1,   F-actin↓, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 3,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↓, 1,   RAGE↓, 1,   TRIB3↑, 1,   TumCI↓, 3,   TumCMig↓, 5,   TumCP↓, 3,   TumMeta↓, 3,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 1,   HIF-1↓, 1,   Hif1a↓, 3,   VEGF↓, 5,   VEGFR2↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CXCR4↓, 3,   IL1↓, 1,   IL2↓, 1,   IL4↓, 1,   IL6↓, 3,   Imm↝, 1,   Inflam↓, 3,   NF-kB↓, 5,   PGE2↓, 1,   PSA↓, 1,   TNF-α↓, 2,  

Protein Aggregation ⓘ

BACE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 3,   ChemoSen↑, 4,   Dose↝, 3,   eff↓, 1,   eff↑, 5,   eff↝, 1,   Half-Life↓, 1,   Half-Life↑, 1,   RadioS↑, 2,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AR↓, 1,   EGFR↓, 1,   GutMicro↑, 1,   IL6↓, 3,   PSA↓, 1,   RAGE↓, 1,   TRIB3↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiDiabetic↑, 1,   AntiTum↑, 2,   cardioP↑, 1,   CardioT↑, 1,   chemoP↑, 3,   hepatoP↓, 1,   neuroP↑, 3,   Obesity↓, 2,   OS↑, 1,   radioP↑, 1,   Risk↓, 1,   toxicity↓, 2,   toxicity↑, 1,   TumVol↓, 2,  
Total Targets: 152

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

4-HNE↓, 1,   antiOx↑, 20,   ARE↑, 2,   Catalase↑, 10,   Ferroptosis↓, 1,   GPx↑, 7,   GPx4↑, 1,   GSH↑, 10,   GSR↑, 2,   HDL↑, 1,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 7,   Keap1↓, 1,   lipid-P↓, 4,   lipid-P↑, 1,   MDA↓, 10,   NOX4↓, 1,   NQO1↑, 2,   NRF2↓, 1,   NRF2↑, 19,   ROS?, 1,   ROS↓, 29,   SAM-e↑, 1,   SOD↑, 15,   SOD1↑, 1,   TAC↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   ATP↝, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   ALAT↓, 1,   AMPK↑, 1,   CRM↑, 1,   glucose↓, 1,   glucose↝, 2,   GLUT2↑, 1,   HMG-CoA↓, 1,   LDH↓, 3,   LDH↑, 1,   LDL↓, 1,   NAD↝, 1,   NADPH↓, 1,   PPARα↑, 3,   PPARα↝, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 2,   Apoptosis↓, 1,   Casp↓, 1,   Casp3↓, 2,   cl‑Casp3↓, 1,   Casp9↓, 2,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   HGF/c-Met↑, 1,   iNOS↓, 1,   JNK↓, 1,   MAPK↓, 5,   MCT1↓, 1,   necrosis↓, 1,   TRPV1↑, 2,  

Kinase & Signal Transduction ⓘ

TRPV3↑, 2,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↓, 3,   other↑, 4,   other↝, 4,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNMT1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Choline↑, 1,   p‑ERK↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   PI3K↓, 1,   PI3K↑, 2,   TRPM7↓, 3,   TRPM7⇅, 1,   Wnt↑, 1,  

Migration ⓘ

5LO↓, 3,   AntiAg↑, 4,   APP↓, 1,   Ca+2↓, 1,   Ca+2↑, 2,   Ca+2↝, 1,   MMP-10↝, 1,   MMP9↓, 2,   PKCδ↑, 1,   serineP↓, 1,   TRPC1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,   NO↓, 4,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↓, 2,   BBB↑, 7,   GastroP↑, 2,   IBI↑, 1,   OCLN↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 11,   CRP↓, 3,   CXCR4↓, 1,   IFN-γ↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 7,   IL6↓, 7,   Imm↑, 2,   Inflam↓, 28,   Inflam↑, 1,   NF-kB↓, 9,   NF-kB↑, 2,   PGE2↓, 3,   TLR2↓, 1,   TLR4↓, 4,   TNF-α↓, 13,   VitD↑, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 12,   ADAM10↑, 1,   BChE↓, 5,   BDNF↑, 5,   GABA↝, 1,   NGF↑, 1,   tau↓, 5,   p‑tau↓, 2,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 13,   NLRP3↓, 2,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 4,   BioAv↑, 9,   BioAv⇅, 1,   BioAv↝, 3,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 6,   eff↑, 15,   eff↝, 1,   Half-Life↓, 2,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 2,   BMD↑, 1,   BMPs↑, 1,   BP↓, 2,   Calcium↑, 1,   CRP↓, 3,   GutMicro↑, 5,   hs-CRP↓, 1,   IL6↓, 7,   LDH↓, 3,   LDH↑, 1,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 3,   AntiDiabetic↑, 6,   cardioP↑, 15,   chemoP↑, 1,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↓, 1,   cognitive↑, 17,   hepatoP↑, 9,   memory↑, 11,   motorD↓, 1,   motorD↑, 3,   neuroP↑, 48,   Obesity↓, 6,   OS↑, 1,   Pain↓, 4,   RenoP↑, 3,   Risk↓, 6,   toxicity↓, 5,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 7,   Diar↓, 1,   Sepsis↓, 1,  
Total Targets: 188

Scientific Paper Hit Count for: neuroP, neuroprotective
21 Thymoquinone
20 Alpha-Lipoic-Acid
19 Resveratrol
18 Magnetic Fields
18 Quercetin
16 Silymarin (Milk Thistle) silibinin
15 Urolithin
14 Chlorogenic acid
14 Hydrogen Gas
12 Curcumin
12 Rosmarinic acid
11 Baicalein
11 Lycopene
10 Ashwagandha(Withaferin A)
10 Carvacrol
9 Berberine
9 Bacopa monnieri
9 Ferulic acid
9 Honokiol
8 Moringa oleifera
8 Sulforaphane (mainly Broccoli)
7 Allicin (mainly Garlic)
7 Chrysin
7 Piperine
7 Huperzine A/Huperzia serrata
7 Taurine
6 Apigenin (mainly Parsley)
6 Selenium NanoParticles
6 EGCG (Epigallocatechin Gallate)
6 Fisetin
6 Ginseng
6 Mushroom Lion’s Mane
6 Phenylbutyrate
6 Silicic Acid
5 Astaxanthin
5 Vitamin C (Ascorbic Acid)
5 Capsaicin
5 Crocetin
5 Luteolin
5 Piperlongumine
5 Shankhpushpi
5 Shikonin
5 Vitamin E
5 Vitamin B5,Pantothenic Acid
4 Boron
4 Boswellia (frankincense)
4 Carnosic acid
4 Carnosine
4 Propolis -bee glue
4 Folic Acid, Vit B9
4 Shilajit/Fulvic Acid
4 Magnetic Field Rotating
4 Pterostilbene
4 Vitamin B12
3 Anthocyanins
3 Artemisinin
3 Biochanin A
3 Betulinic acid
3 Vitamin B6,pyridoxine
3 Caffeic acid
3 Exercise
3 Celastrol
3 Coenzyme Q10
3 Cysteamine
3 diet Short Term Fasting
3 Methylene blue
3 Magnolol
3 Melatonin
3 nicotinamide adenine dinucleotide
3 Rutin
3 Selenite (Sodium)
3 Ursolic acid
2 Baicalin
2 beta-carotene(VitA)
2 borneol
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Chlorophyllin
2 Calorie Restriction Mimetics
2 Spermidine
2 Metformin
2 Ellagic acid
2 Emodin
2 Ginkgo biloba
2 EMF
2 Naringin
2 Phosphatidylserine
2 Chemotherapy
2 Vitamin D3
2 Vitamin K2
1 Astragalus
1 alpha Linolenic acid
1 Aluminum
1 doxorubicin
1 Butyrate
1 Paclitaxel
1 chitosan
1 Choline
1 Cinnamon
1 Selenium
1 Hydroxycinnamic-acid
1 Aspirin -acetylsalicylic acid
1 Silver-NanoParticles
1 Dichloroacetate
1 Bortezomib
1 diet Methionine-Restricted Diet
1 diet FMD Fasting Mimicking Diet
1 MCToil
1 Methylsulfonylmethane
1 Psoralidin
1 Salvia officinalis
1 Aromatherapy
1 Sesame seeds and Oil
1 Anti-oxidants
1 Aflavin-3,3′-digallate
1 Vitamin A, Retinoic Acid
1 Vitamin B1/Thiamine
1 Vitamin B3,Niacin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1105  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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