RadioS Cancer Research Results

RadioS, RadioSensitizer: Click to Expand ⟱
Source:
Type:
A radiosensitizer is an agent that makes cancer cells more sensitive to the damaging effects of radiation therapy. By using a radiosensitizer, clinicians aim to enhance the effectiveness of radiation treatment by either increasing the damage incurred by tumor cells or by interfering with the cancer cells’ repair mechanisms. This can potentially allow for lower doses of radiation, reduced side effects, or improved treatment outcomes.
Pathways that help Radiosensitivity: downregulating HIF-1α, increase SIRT1, Txr

List of Natural Products with radiosensitizing properties:
-Curcumin:modulate NF-κB, STAT3 and has been shown in preclinical studies to enhance the effects of radiation by inhibiting cell survival pathways.
-Resveratrol:
-EGCG:
-Quercetin:
-Genistein:
-Parthenolide:

How radiosensitizers inhibit the thioredoxin (Trx) system in cellular contexts. Notable radiosensitizers, including:
-gold nanoparticles (GNPs),
-gold triethylphosphine cyanide ([Au(SCN) (PEt3)]),
-auranofin, ceria nanoparticles (CONPs),
-curcumin and its derivatives,
-piperlongamide,
-indolequinone derivatives,
-micheliolide,
-motexafin gadolinium, and
-ethane selenide selenidazole derivatives (SeDs)
Scientific Papers found: Click to Expand⟱
6222- CUR,    Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials
- Review, Var, NA
RadioS↑, ChemoSen↑, MMPs↓, TumMeta↓, TumCI↓, Inflam↓, NF-kB↓, BioAv↓, BioAv↑, MAPK↓, PI3K↓, Akt↓, *ROS↓, *MDA↓, *lipid-P↓, *Half-Life↓, mTOR↓,
6218- CUR,    Exploring the Thioredoxin System as a Therapeutic Target in Cancer: Mechanisms and Implications
- Review, Var, NA
NF-kB↓, TrxR↓, ROS↑, TumMeta↓, TumCD↑, RadioS↑, BioAv↝, BioAv↑,
2811- CUR,    Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study
- Human, Pca, NA
*antiOx↑, radioP↑, RadioS∅, *TAC↑, *SOD↓,
1980- CUR,  Rad,    Thioredoxin reductase-1 (TxnRd1) mediates curcumin-induced radiosensitization of squamous carcinoma cells
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
selectivity↑, RadioS↑, TrxR↓, ROS↑, ERK↑, Dose∅, cl‑PARP↑,
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
ChemoSen↑, NF-kB↓, *STAT3↓, *COX2↓, *Akt↓, *NRF2↑, *HO-1↑, *GPx↑, *NADPH↑, *GSH↑, *ROS↓, *p300↓, radioP↑, chemoP↑, RadioS↑,
1488- CUR,    Anti-Cancer and Radio-Sensitizing Effects of Curcumin in Nasopharyngeal Carcinoma
RadioS↑, ChemoSen↑,
1487- CUR,    Relationship and interactions of curcumin with radiation therapy
- Review, Var, NA
RadioS↑, ChemoSen↑, NF-kB↓, radioP↑, BioAv↓, *toxicity↓,
1486- CUR,    Curcumin and lung cancer--a review
- Review, Lung, NA
RadioS↑, ChemoSen↑,
133- CUR,    Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
miR-143↑, PDK1↓, FOXD3↑, TumCP↓, TumCMig↓, *Inflam↓, *antiOx↑, *chemoPv↑, RadioS↑, ChemoSen↑,
14- CUR,    Curcumin, a Dietary Component, Has Anticancer, Chemosensitization, and Radiosensitization Effects by Down-regulating the MDM2 Oncogene through the PI3K/mTOR/ETS2 Pathway
- vitro+vivo, Pca, PC3
PI3K/mTOR/ETS2↓, MDM2↓, P21↑, Apoptosis↑, TumCP↓, eff↑, RadioS↑,
12- CUR,    Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
- in-vitro, MB, DAOY
HH↓, Shh↓, Gli1↓, PTCH1↓, cMyc↓, n-MYC↓, cycD1/CCND1↓, Bcl-2↓, NF-kB↓, Akt↓, β-catenin/ZEB1↓, survivin↓, Apoptosis↑, ChemoSen↑, RadioS↑, eff↑,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, eff↑, eff↑, other↝, RadioS↑, toxicity↓, Dose↝, eff↑, eff↑, eff↑, toxicity↝, eff↓,
6681- DCA,    Dichloroacetate (DCA) in Cancer Care
PDK1↓, Apoptosis↑, ROS↑, lactateProd↓, Dose↝, eff↝, toxicity↓, NP/CIPN↑, Dose↝, *BioAv↑, *Half-Life↓, GSTZ1↝, Glycolysis↓, OXPHOS↑, MPT↑, Cyt‑c↑, AIF↑, Casp↑, CSCs↓, Remission↑, ChemoSen↑, RadioS↑, toxicity↑,
4901- DCA,  Sal,    Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
- Review, NSCLC, NA
Glycolysis↓, OXPHOS↑, PDKs↓, ROS↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, RadioS↑, TumAuto↑, mTOR↓, LC3s↓, p62↑, TumCG↓, OS↑, toxicity↝, ChemoSen↑, eff↑, eff↑, Ferritin↓, CSCs↓, EMT↓, ROS↑, Cyt‑c↑, Casp3↑, ER Stress↑, selectivity↑, eff↑, TumCG↓,
5195- DCA,  Rad,    Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells
- in-vitro, BC, 4T1 - in-vitro, BC, EMT6
PDKs↑, ROS↑, p‑PDH↓, ECAR↓, lactateProd↓, selectivity↓, RadioS↑,
1870- DCA,  Rad,    Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation
- in-vitro, Pca, PC3
TumCCA↑, Apoptosis↑, MMP↓, eff↑, RadioS↑,
6694- DFC,    Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent
- Review, Var, NA
COX2↓, PGE2↓, angioG↓, ChemoSen↑, RadioS↑, Dose↝, toxicity↝, toxicity↝, BioAv↑, Half-Life↝, lactateProd↓, eff↑, *AntiAg↑,
1849- dietFMD,    The emerging role of fasting-mimicking diets in cancer treatment
- Review, Var, NA
TumCG↓, toxicity∅, BG↓, IGF-1↓, mTOR↓, M2 MC↓, eff↑, ChemoSen↑, QoL↑, RadioS↑, selectivity↑,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27↑, Insulin↓, IGF-1↓,
2264- dietMet,    Methionine restriction for cancer therapy: From preclinical studies to clinical trials
- Review, Var, NA
TumCP↓, *ROS?, ChemoSen↑, RadioS↑, eff↑, ROS↑, selectivity↑, TS↓, eff↑,
1897- dietMet,    Methionine metabolism in health and cancer: a nexus of diet and precision medicine
- Review, Var, NA
OS↑, TumCG↓, TumCCA↑, ChemoSen↑, RadioS↑,
1896- dietMet,    Dietary methionine links nutrition and metabolism to the efficacy of cancer therapies
- in-vivo, CRC, NA
TumCG↓, *GSH↓, RadioS↑, eff↑,
5188- dietMet,    Dietary methionine links nutrition and metabolism to the efficacy of cancer therapies
- in-vivo, Var, NA
AntiAge↑, MethCyc↓, TumCG↓, ChemoSen↑, RadioS↑, OS↑, GSH↓,
5191- dietMet,    Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade
- in-vitro, Colon, HT29
ChemoSen↑, RadioS↑, Ferroptosis↑, eff↑, eff↑, GSH↓, eff↓,
5069- dietSTF,    The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases
- Review, Var, NA
Risk↓, ChemoSen↑, RadioS↑, *Dose↝, *Dose↝, *Dose↝, *LDL↓, *CRP↓, *TNF-α↓, TumAuto↓, GLUT1↓, GLUT2↓, glucose↓, IGF-1↓, Insulin↓, mTOR↓, mTORC1↓, AMPK↑, Warburg↓, OXPHOS↑, ROS↑, DNAdam↑, JAK1↓, STAT↓, TumCP↓, QoL↑,
1626- dietSTF,  dietFMD,    When less may be more: calorie restriction and response to cancer therapy
- Review, Var, NA
CRM↑, ChemoSen↑, RadioS↑, eff↑, eff↑, IGF-1↓, TumCG↓, AMPK↑, eff↑, ChemoSen↑, RadioS↑, ROS↑, DNAdam↑, eff↑, HO-1↓,
4913- DSF,    Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
- Review, Var, NA
Apoptosis↑, tumCV↑, eff↑, toxicity↓, antiNeop↑, ChemoSen↑, RadioS↑, OS↑, ROS↑, SOD↓, MMP1↓, eff↑, Half-Life↓,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, eff↑, CSCs↓, Dose↝, Half-Life↑,
4915- DSF,  Cu,    Disulfiram: A novel repurposed drug for cancer therapy
- Review, Var, NA
ROS↑, TumCD↑, NF-kB↓, CSCs↓, ChemoSen↑, RadioS↑, eff↑, selectivity↑, Proteasome?,
5011- DSF,  Cu,    Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens
- Review, Var, NA
BioAv↓, eff↓, ChemoSen↑, RadioS↑,
4832- EA,    Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid
*antiOx↑, *AntiCan↑, TumCMig↓, angioG↓, ChemoSen↑, RadioS↑, *chemoP↑, *BioAv↓, eff↓, selectivity↑, MMP2↓, MMP9↓, VEGF↓, TumCCA↑, Apoptosis↑, ROS↑, BioAv↑,
6801- EA,    A radiotherapeutic paradox: ellagic acid sensitizes tumors while attenuating radiation-induced myocardial injury
- vitro+vivo, BC, 4T1
TumCCA↑, CDK4↓, RadioS↑, TumCG↓, *radioP↑, *cardioP↑, *antiOx↑, *ROS↓, Dose↑, selectivity↑, BioAv↓,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
4680- EGCG,    The Potential of Epigallocatechin Gallate in Targeting Cancer Stem Cells: A Comprehensive Review
- Review, Var, NA
CSCs↓, EMT↓, TumMeta↓, RadioS↑, ChemoSen↑, BioAv↓,
3213- EGCG,  Rad,    Epigallocatechin-3-gallate Enhances Radiation Sensitivity in Colorectal Cancer Cells Through Nrf2 Activation and Autophagy
- in-vitro, CRC, HCT116
RadioS↑, TumCP↓, NRF2↑,
5256- EP,    Pulsed electric fields: a sharp sword in the battle against cancers
- Review, Var, NA
BioAv↑, TumCD↑, MMP↓, Apoptosis↑, TumCCA↑, Imm↑, RadioS↑, ChemoSen↑,
6390- Eug,    Molecular mechanisms of eugenol as an antitumour bioactive compound: A comprehensive review
- Review, Var, NA
TumCCA↑, angioG↓, TumMeta↓, tumCV↓, Casp3↑, Casp6↑, DFF45↑, PARP↑, ROS↑, Cyt‑c↑, MPT↑, *ROS↓, NF-kB↓, COX2↓, 5LO↓, EMT↓, Snail↓, E-cadherin↑, Vim↓, PI3K↓, Akt↓, mTORC2↓, TumAuto↑, FOXO3↓, Apoptosis↑, ChemoSen↑, RadioS↑, DNMT1↓, DNMT3A↓,
6333- Eug,  Cisplatin,  Rad,    Eugenol Exerts Apoptotic Effect and Modulates the Sensitivity of HeLa Cells to Cisplatin and Radiation
- in-vitro, Cerv, HeLa
TumCP↓, LDH↝, ChemoSen↑, RadioS↑, Casp3↑, BAX↑, Cyt‑c↑, Casp9↑, Bcl-2↓, COX2↓, IL1β↓, ROS↑, NF-kB↓, COX2↓, TumCCA↓, Thiols↓, GSH↓,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, eff↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
2852- FIS,    A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
- Review, CRC, NA
Risk↓, P53↑, MDM2↓, COX2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,
2841- FIS,    Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer
- in-vitro, Nor, RAW264.7 - in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
*Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, Apoptosis↓, ER Stress↑, Ca+2↑, PERK↑, ATF4↑, CHOP↑, GRP78/BiP↑, tumCV↓, LDH↑, Casp3↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, p‑eIF2α↑, RadioS↑,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,

Showing Research Papers: 101 to 150 of 243
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 243

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-375↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 1,   Ferroptosis↑, 1,   GPx↓, 1,   GSH↓, 5,   GSH↑, 1,   GSTs↝, 1,   GSTZ1↓, 1,   GSTZ1↝, 1,   HO-1↓, 2,   HO-2↓, 1,   lipid-P↓, 1,   lipid-P↑, 1,   NRF2↓, 1,   NRF2↑, 1,   OXPHOS↑, 4,   PYCR1↓, 1,   ROS↓, 3,   ROS↑, 25,   SOD↓, 4,   TBARS↑, 1,   Thiols↓, 1,   TrxR↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 3,   ATP↓, 1,   CDC25↓, 1,   EGF↓, 1,   FGFR1↓, 3,   Insulin↓, 4,   MMP↓, 7,   MPT↑, 2,   mtDam↑, 2,   OCR↑, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 4,   CAIX↓, 1,   cMyc↓, 5,   CRM↑, 1,   ECAR↓, 1,   ECAR↝, 1,   glucose↓, 1,   GlucoseCon↓, 2,   GLUT2↓, 1,   Glycolysis↓, 5,   HMG-CoA↓, 1,   lactateProd↓, 6,   LDH↓, 1,   LDH↑, 1,   LDH↝, 1,   lipoGen↓, 1,   MethCyc↓, 1,   p‑PDH↓, 1,   PDK1?, 2,   PDK1↓, 3,   PDKs↓, 1,   PDKs↑, 1,   PI3K/mTOR/ETS2↓, 1,   PKM2↓, 1,   polyA↓, 1,   SIRT1↓, 1,   TS↓, 2,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 11,   Akt↑, 1,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 16,   Bak↑, 2,   BAX↓, 1,   BAX↑, 4,   Bax:Bcl2↑, 3,   Bcl-2↓, 6,   Bcl-xL↓, 2,   BID↑, 1,   BIM↑, 1,   Casp↑, 4,   Casp3↑, 10,   cl‑Casp3↑, 2,   Casp6↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 6,   cl‑Casp9↑, 2,   CK2↓, 1,   Cyt‑c↑, 9,   Diablo↑, 3,   DR5↑, 1,   Fas↑, 2,   Ferroptosis↑, 1,   iNOS↓, 1,   JNK↑, 2,   MAPK↓, 4,   Mcl-1↓, 2,   MDM2↓, 3,   Myc↓, 1,   Myc↑, 1,   NOXA↑, 2,   p27↑, 3,   Proteasome?, 1,   PUMA↑, 2,   survivin↓, 3,   Telomerase↓, 1,   TRAIL↑, 1,   TumCD↑, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

FOXD3↑, 1,   p70S6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 3,   miR-143↑, 1,   other↝, 2,   tumCV↓, 3,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 4,   HSF1↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   IRE1↑, 3,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,   LC3II↑, 1,   LC3s↓, 1,   p62↑, 2,   TumAuto↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 8,   DNMT1↓, 1,   DNMT3A↓, 1,   P53↑, 7,   PARP↑, 2,   cl‑PARP↑, 4,   PCNA↓, 1,   SIRT6↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 6,   CDK4↓, 7,   cycD1/CCND1↓, 6,   cycE/CCNE↓, 5,   P21↑, 8,   p‑RB1↓, 2,   TumCCA↓, 1,   TumCCA↑, 17,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CDK8↓, 2,   cFos↓, 3,   CSCs↓, 7,   EMT↓, 10,   ERK↓, 1,   ERK↑, 2,   p‑ERK↓, 1,   FGF↓, 1,   FGFR2↓, 1,   FOXO↑, 1,   FOXO3↓, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1↓, 4,   IGF-1↑, 1,   miR-34a↑, 1,   mTOR↓, 9,   mTORC1↓, 3,   mTORC2↓, 2,   n-MYC↓, 1,   NOTCH↓, 2,   P90RSK↓, 1,   PI3K↓, 8,   PTCH1↓, 1,   PTEN↑, 2,   Shh↓, 2,   STAT↓, 1,   STAT3↓, 2,   p‑STAT3↓, 3,   STAT6↓, 1,   TCF-4↓, 2,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 11,   tyrosinase↓, 1,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AP-1↓, 2,   Ca+2↑, 2,   Ca+2↝, 1,   E-cadherin↓, 1,   E-cadherin↑, 3,   p‑FAK↓, 1,   Ki-67↓, 1,   MMP1↓, 1,   MMP2↓, 6,   MMP7↓, 2,   MMP9↓, 7,   MMPs↓, 1,   N-cadherin↓, 1,   NEDD9↓, 1,   PDGF↓, 1,   PKCδ↓, 1,   SMAD3↓, 2,   Snail↓, 3,   TGF-β↓, 4,   TIMP1↑, 1,   TumCA↓, 1,   TumCI↓, 6,   TumCMig↓, 6,   TumCMig↑, 1,   TumCP↓, 12,   TumMeta↓, 7,   Twist↓, 3,   uPA↓, 3,   Vim↓, 4,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   ATF4↑, 4,   EGFR↓, 3,   Endoglin↑, 1,   Hif1a↓, 2,   NO↑, 1,   VEGF↓, 5,   VEGFR2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   NHE1↓, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2↓, 12,   COX2↑, 1,   IL1β↓, 1,   IL6↓, 2,   Imm↑, 3,   Inflam↓, 4,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   M2 MC↓, 1,   NF-kB↓, 18,   p‑NF-kB↓, 1,   PD-L1↓, 1,   PD-L1↑, 1,   PGE2↓, 3,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 7,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 7,   BioAv↝, 2,   ChemoSen↓, 1,   ChemoSen↑, 32,   Dose↑, 2,   Dose↝, 8,   Dose∅, 2,   eff↓, 5,   eff↑, 44,   eff↝, 2,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 2,   P450↝, 1,   RadioS↑, 51,   RadioS∅, 1,   selectivity↓, 1,   selectivity↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AR↓, 1,   AST↓, 2,   BG↓, 2,   EGFR↓, 3,   Ferritin↓, 1,   IL6↓, 2,   Ki-67↓, 1,   LDH↓, 1,   LDH↑, 1,   LDH↝, 1,   Myc↓, 1,   Myc↑, 1,   PD-L1↓, 1,   PD-L1↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 2,   antiNeop↑, 1,   AntiTum↑, 1,   chemoP↑, 2,   ChemoSideEff↓, 2,   fatigue↓, 1,   NP/CIPN↑, 1,   OS↑, 4,   QoL↑, 2,   QoL∅, 1,   radioP↑, 3,   Remission↑, 1,   Risk↓, 2,   toxicity↓, 3,   toxicity↑, 1,   toxicity↝, 6,   toxicity∅, 1,   TumVol↓, 1,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 311

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 5,   GPx↑, 1,   GSH↓, 1,   GSH↑, 4,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 1,   NRF2↓, 1,   NRF2↑, 2,   OXPHOS↑, 1,   ROS?, 1,   ROS↓, 5,   SOD↓, 1,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑cMyc↑, 1,   GlucoseCon↑, 1,   LDL↓, 1,   NADPH↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   p300↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   CRP↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 5,   TNF-α↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 1,   Dose↝, 3,   Half-Life↓, 2,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 2,   chemoP↑, 1,   chemoPv↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   radioP↑, 1,   toxicity↓, 1,   toxicity∅, 4,  
Total Targets: 45

Scientific Paper Hit Count for: RadioS, RadioSensitizer
58 Radiotherapy/Radiation
18 Curcumin
10 Silver-NanoParticles
8 Betulinic acid
8 Propolis -bee glue
8 Resveratrol
7 Baicalein
6 Berberine
6 salinomycin
6 diet Methionine-Restricted Diet
6 Ellagic acid
5 Chemotherapy
5 Copper and Cu NanoParticles
5 Dichloroacetate
5 Disulfiram
5 Fisetin
5 Thymoquinone
4 Atorvastatin
4 Cisplatin
4 Chrysin
4 Honokiol
4 Magnetic Fields
4 Phenylbutyrate
4 Sulforaphane (mainly Broccoli)
4 Selenium NanoParticles
4 Selenite (Sodium)
3 Hyperthermia
3 Selenium
3 Apigenin (mainly Parsley)
3 Ashwagandha(Withaferin A)
3 brusatol
3 Crocetin
3 Eugenol
3 diet FMD Fasting Mimicking Diet
3 Gold NanoParticles
3 Luteolin
3 Oxygen, Hyperbaric
3 Piperlongumine
3 Parthenolide
3 Sulfasalazine
2 3-bromopyruvate
2 Auranofin
2 Allicin (mainly Garlic)
2 Anti-oxidants
2 Astaxanthin
2 Beta-Caryophyllene
2 Brucea javanica
2 Caffeic acid
2 Capsaicin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 chemodynamic therapy
2 Celastrol
2 diet Short Term Fasting
2 EGCG (Epigallocatechin Gallate)
2 Ferulic acid
2 Gambogic Acid
2 Niclosamide (Niclocide)
2 Oleuropein
2 Quercetin
2 Rosmarinic acid
2 Silymarin (Milk Thistle) silibinin
2 Vitamin D3
1 2-DeoxyGlucose
1 Astragalus
1 Alpha-Lipoic-Acid
1 Vitamin A, Retinoic Acid
1 Vitamin C (Ascorbic Acid)
1 Artemisinin
1 Aspirin
1 Baicalin
1 Berbamine
1 Biochanin A
1 Bromelain
1 borneol
1 Boron
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Zinc
1 Carvacrol
1 Thymol-Thymus vulgaris
1 carboplatin
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Coenzyme Q10
1 Cucurbitacin
1 Diclofenac
1 immunotherapy
1 Electrical Pulses
1 Hydroxycinnamic-acid
1 Magnolol
1 Lycopene
1 Melatonin
1 Metformin
1 HydroxyTyrosol
1 Piperine
1 Psoralidin
1 Oxaliplatin
1 Shikonin
1 Urolithin
1 Vitamin K2
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1107  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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