Half-Life Cancer Research Results

Half-Life, Half-Life: Click to Expand ⟱
Source:
Type:
For many drugs, the half-life is the time it takes for half of the drug’s active substance to be eliminated from the bloodstream.
In medicine, knowing a drug’s half-life helps in designing treatment regimens that reduce adverse effects.
Scientific Papers found: Click to Expand⟱
6227- CUR,    Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, JAK↓, STAT3↓, MAPK↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, GSK‐3β↓, cMyc↓, survivin↓, Axin2↑, TumCCA↑, PTEN↑, P53↑, ROS↑, Casp3↑, PARP↑, Ferroptosis↑, angioG↓, TumCI↓, TumMeta↓, BioAv↓, Half-Life↓, ChemoSen↑,
6222- CUR,    Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials
- Review, Var, NA
RadioS↑, ChemoSen↑, MMPs↓, TumMeta↓, TumCI↓, Inflam↓, NF-kB↓, BioAv↓, BioAv↑, MAPK↓, PI3K↓, Akt↓, *ROS↓, *MDA↓, *lipid-P↓, *Half-Life↓, mTOR↓,
6770- CUR,    A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin
- Review, Nor, NA
*AntiBio↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *Half-Life↓,
6591- DAS,    Dasatinib in solid tumors
- Review, Var, NA
Src↓, PDGF↓, ABL1↓, BioAv↝, Half-Life↝, Dose↝, eff↑,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2/PTGS2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, eff↑, eff↑, other↝, RadioS↑, toxicity↓, Dose↝, eff↑, eff↑, eff↑, toxicity↝, eff↓,
6681- DCA,    Dichloroacetate (DCA) in Cancer Care
PDK1↓, Apoptosis↑, ROS↑, lactateProd↓, Dose↝, eff↝, toxicity↓, NP/CIPN↑, Dose↝, *BioAv↑, *Half-Life↓, GSTZ1↝, Glycolysis↓, OXPHOS↑, MPT↑, Cyt‑c↑, AIF↑, Casp↑, CSCs↓, Remission↑, ChemoSen↑, RadioS↑, toxicity↑,
6679- DCA,    GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial
- Trial, Melanoma, NA
PDK1↓, Half-Life↝, eff↑, NP/CIPN↑, Dose↝, Half-Life↝,
1882- DCA,    Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
- Analysis, NA, NA
PDKs↓, PDH↑, lactateProd↓, Half-Life∅,
6676- Deg,    Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry
- Review, Var, NA
TumCP↓, Apoptosis↑, NF-kB↓, Wnt↓, TumCCA↑, TumMeta↑, antiOx↑, Inflam↓, angioG↓, Half-Life↑, MMP2↓, MMP9↓, Casp9↑, Casp3↑, EMT↓, PTEN↑, ChemoSen↑, toxicity↑, *BBB↑,
6670- Deg,    Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats
- in-vivo, Nor, NA
*Half-Life↑, *BioAv↝,
6694- DFC,    Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, angioG↓, ChemoSen↑, RadioS↑, Dose↝, toxicity↝, toxicity↝, BioAv↑, Half-Life↝, lactateProd↓, eff↑, *AntiAg↑,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2/PTGS2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
4913- DSF,    Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
- Review, Var, NA
Apoptosis↑, tumCV↑, eff↑, toxicity↓, antiNeop↑, ChemoSen↑, RadioS↑, OS↑, ROS↑, SOD↓, MMP1↓, eff↑, Half-Life↓,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, eff↑, CSCs↓, Dose↝, Half-Life↑,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
1614- EA,    Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice
- Human, Nor, NA
*BioEnh↝, *Half-Life∅,
6604- Ech,    Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion
- Human, Nor, NA
*BioAv↑, *Half-Life↝, *Dose↝, Dose?,
7222- EGb 761,    Ginkgo biloba extract EGb 761® in the symptomatic treatment of mild-to-moderate dementia: a profile of its use
- Review, AD, NA
*cognitive↑, *toxicity↓, *Dose↝, *BioAv↑, *Half-Life↑, *neuroP↑, *Half-Life↝, *Dose↝, *other↝, *eff↑,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*Dose∅, Half-Life∅, BioAv∅, BBB↑, toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
6782- EGCG,    Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability
- Human, Nor, NA
*Dose↝, BioAv↝, Half-Life↝,
6785- EGCG,    Epigallocatechin-3-gallate at the nanoscale: a new strategy for cancer treatment
- Review, Var, NA
AntiCan↑, BioAv↓, BioAv↑, EPR↑, TumCG↓, *Half-Life↝, BioAv↑, eff↑, eff↑, eff↑, NF-kB↓, ROS↑, ChemoSen↑, *toxicity↝,
6789- EGCG,    Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?
- Review, Var, NA
BioAv↓, Half-Life↝, Half-Life↝, BioAv↝, *BioAv↑, *BioAv↓, *BioAv↑, *BioAv↑, *Dose↝, *toxicity↝,
2561- EGCG,  ASA,    Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment
- ex-vivo, Nor, NA
AntiAg↑, eff↑, Half-Life↝, other∅,
6575- EU,    Eurycomanone from Eurycoma longifolia Jack upregulates neurotrophin-3 gene expression in retinal Müller cells in vitro
- in-vivo, Nor, NA
*Hypoxia↓, *NTF3/NT-3↑, *other↑, *Half-Life↓,
6581- EU,    Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract
- in-vitro, Colon, Caco-2 - in-vivo, Nor, NA
*Half-Life↓, *BioAv↝,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
2824- FIS,    Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics
- Review, Var, NA
*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
6910- FIS,    Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer
- in-vitro, Lung, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumCI↓, TumAuto↝, ChemoSen↑, RadioS↑, chemoP↑, BioAv↓, Half-Life↓,
6895- FIS,    Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study
- in-vivo, Nor, NA
*neuroP↑, *cardioP↑, *chemoPv↑, *AntiDiabetic↑, *Inflam↓, *ROS↓, *BioAv↓, *BioAv↑, *eff↑, *Half-Life↓,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, eff↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, eff↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
6992- Form,    Formononetin: pharmacological properties and therapeutic potential
- Review, Nor, NA
*BMD↑, *BioAv↑, *Half-Life↝, *BioAv↑,
7026- Fuc,    Fucoidan
- Review, AD, NA
*Inflam↓, *ROS↓, *BioAv↓, *GutMicro↑, *neuroP↑, *glucose↝, *AntiThr↑, *chemoP↑, *Half-Life↝, *BBB∅, *AntiAge↑, Risk↑,
7027- GA,    Pharmacokinetics of gallic acid and its relative bioavailability from tea in healthy humans
- Human, Nor, NA
AntiCan↑, *Inflam↓, *BioAv↑, *Half-Life↓, *eff↝,
7069- GABA,    United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)
- Review, Nor, NA
*toxicity↓, *BP↓, *AntiDiabetic↑, *AntiCan↑, *antiOx↑, *Inflam↓, *AntiBio↑, *other↝, *cognitive↑, *GH↑, *Sleep↑, *BioAv↑, *Half-Life↝, *BBB↓, *eff↑,
7065- GamB,    Gambogic acid: A review of its pharmacological mechanisms against cancer
- Review, Var, NA
AntiTum↑, Apoptosis↑, TumCCA↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, P-gp/ABCB1↓, Shh↓, Pyro↑, Casp3↑, GSDME↑, ChemoSen↑, RadioS↑, BioAv↓, Bcl-2↓, Mcl-1↓, BAX↑, Half-Life↓, ROS↑, miR-21↓, MMP2↓, MMP9↓,
7062- GamB,  Chit,    Modified chitosan derivative micelle system for natural anti-tumor product gambogic acid delivery
- in-vivo, Nor, NA
*Half-Life↑, *toxicity↓,
7087- GAR,    Garcinol as an Epigenetic Modulator: Mechanisms of Anti-Cancer Activity and Therapeutic Potential
- Review, Var, NA
HATs↓, p300↓, CBP↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, Inflam↓, angioG↓, TumCP↓, TumMeta↓, TumCCA↑, EMT↓, CSCs↓, P53↑, TrxR↓, ROS↑, JNK↑, DNAdam↑, mt-Apoptosis↑, ER Stress↑, CHOP/DDIT3↑, DDIT4↑, TRIB3↑, SESN2↑, miR-218↑, eff↑, ChemoSen↑, BioAv↓, Half-Life↓, BioAv↑,
7128- Ge-132,    Pharmacokinetics of germanium after po beta-carboxyethylgermanium sesquioxide in 24 Chinese volunteers
- Trial, Nor, NA
*Half-Life↝,
7103- GEN,    A Comprehensive Review of Genistein's Effects in Preclinical Models of Cervical Cancer
- Review, Cerv, NA
TumCP↓, Apoptosis↑, RadioS↑, ChemoSen↑, *antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, TumCG↓, TumCI↓, TumCCA↑, cl‑PARP↑, selectivity↑, CycB/CCNB1↓, CDK1↓, p‑cDC2↓, p‑ERK↓, p‑p38↑, p‑JNK↑, MMP9↓, TIMP1↑, BioAv↓, BioAv↑, Half-Life↑,
7123- GEO2,    Kinetics of germanium dioxide in rats
- in-vivo, Nor, NA
*Half-Life↝,
6572- Ger,    Pharmacokinetics of Geraniol and Its Metabolites in Mice After Oral Administration
- in-vivo, Nor, NA
BioAv↝, BBB↑, BioAv↝, Half-Life↝,
7135- GI,    Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans
- Trial, Nor, NA
*Dose↝, *Half-Life↝, *antiOx↑, *Inflam↓, *AntiTum↑, *Half-Life↓,
7280- Gins,    Pharmacokinetics of ginsenoside Rb1 and its metabolite compound K after oral administration of Korean Red Ginseng extract
- Trial, Nor, NA
*BioAv↑, *Half-Life↝, *eff↝,
7314- Gos,    The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro
- in-vitro, Melanoma, A375
Dose↝, ROS↑, selectivity↑, Half-Life↓, MMP↓, BioAv↑,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, eff↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
7523- HCA,    Inhibition of ATP Citrate Lyase by Hydroxycitrate-Loaded Exosomes Suppresses the Survival of Lung Adenocarcinoma Cells
- in-vitro, Lung, NA
ACLY↓, BioAv↓, Dose↝, TumCP↓, FASN↓, IDH1↓, Apoptosis↑, ROS↑, Half-Life↝,

Showing Research Papers: 101 to 150 of 241
Prev Page 3 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 241

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

DDIT4↑, 1,   miR-375↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Ferroptosis↑, 1,   GSTZ1↓, 1,   GSTZ1↝, 1,   NRF2↑, 1,   OXPHOS↑, 2,   ROS↓, 1,   ROS↑, 16,   mt-ROS↑, 1,   SOD↓, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ABL1↓, 1,   AIF↑, 1,   ATP↓, 1,   CDC2↓, 1,   CDC25↓, 1,   MMP↓, 7,   MPT↑, 1,   mtDam↑, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMPK↑, 1,   cMyc↓, 1,   FASN↓, 1,   GlutMet↓, 1,   Glycolysis↓, 2,   HMG-CoA↓, 1,   IDH1↓, 1,   lactateProd↓, 4,   lipoGen↓, 1,   PCK1↓, 1,   PDH↑, 1,   PDK1↓, 4,   PDKs↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 9,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 14,   mt-Apoptosis↑, 1,   BAD↑, 1,   Bak↑, 2,   BAX↑, 7,   Bcl-2↓, 8,   Bcl-xL↓, 3,   Casp↑, 5,   Casp1↑, 1,   Casp3↑, 10,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 5,   CBP↓, 1,   Chk2↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 5,   Diablo↑, 2,   DR5↑, 2,   Fas↑, 1,   Ferroptosis↑, 1,   GSDME↑, 1,   HGF/c-Met↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 1,   JNK↑, 3,   p‑JNK↑, 1,   MAPK↓, 7,   Mcl-1↓, 1,   Myc↑, 1,   p27/CDKN1B↑, 2,   p‑p38↓, 1,   p‑p38↑, 1,   Pyro↑, 1,   survivin↓, 3,   Telomerase↓, 2,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   H3↓, 1,   p‑H3↓, 1,   HATs↓, 1,   miR-21↓, 1,   miR-218↑, 1,   other↝, 2,   other∅, 1,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   eIF2α↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   IRE1↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3s↑, 1,   SESN2↑, 1,   TumAuto↑, 1,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   CHK1↑, 1,   DNAdam↑, 3,   DNArepair↓, 1,   DNMTs↓, 2,   P53↑, 7,   PARP↓, 1,   PARP↑, 2,   cl‑PARP↑, 7,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 3,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   P21↓, 1,   P21↑, 2,   TumCCA↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Axin2↑, 1,   p‑cDC2↓, 1,   cFos↓, 1,   CSCs↓, 4,   EMT↓, 5,   ERK↓, 1,   p‑ERK↓, 2,   FGF↓, 1,   FOXO↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   HDAC↓, 2,   HDAC1↓, 1,   IGF-1↓, 1,   mTOR↓, 6,   mTOR⇅, 1,   mTORC1↓, 2,   mTORC2↓, 1,   NOTCH↓, 1,   p300↓, 1,   PI3K↓, 8,   PTEN↑, 6,   RAS↓, 1,   Shh↓, 1,   Src↓, 1,   STAT3↓, 3,   p‑STAT3↑, 1,   TumCG↓, 5,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 2,   E-cadherin↑, 3,   Ki-67↓, 2,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 4,   MMP7↓, 1,   MMP9↓, 7,   MMPs↓, 6,   N-cadherin↓, 1,   PDGF↓, 1,   Rho↓, 1,   Slug↓, 1,   Snail↓, 1,   TIMP1↑, 3,   TIMP2↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TumCI↓, 9,   TumCMig↓, 5,   TumCP↓, 11,   TumMeta↓, 5,   TumMeta↑, 1,   uPA↓, 4,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   ATF4↑, 2,   EGFR↓, 1,   EPR↑, 1,   Hif1a↓, 5,   NO↑, 1,   VEGF↓, 5,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   COX2/PTGS2↑, 1,   Imm↑, 1,   Inflam↓, 4,   JAK↓, 1,   JAK1↓, 1,   NF-kB↓, 13,   PD-L1↑, 1,   PGE2↓, 3,   TLR4↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 10,   BioAv↝, 6,   BioAv∅, 1,   ChemoSen↑, 16,   Dose?, 1,   Dose↝, 12,   Dose∅, 1,   eff↓, 5,   eff↑, 27,   eff↝, 2,   Half-Life↓, 9,   Half-Life↑, 3,   Half-Life↝, 13,   Half-Life∅, 2,   RadioS↑, 10,   selectivity↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

E6↓, 1,   E7↓, 1,   EGFR↓, 1,   Ki-67↓, 2,   Myc↑, 1,   PD-L1↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   antiNeop↑, 1,   AntiTum↑, 2,   chemoP↑, 5,   chemoPv↑, 1,   fatigue↓, 1,   hepatoP↑, 1,   neuroP↑, 1,   NP/CIPN↑, 2,   OS↑, 1,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 1,   Risk↑, 1,   toxicity↓, 3,   toxicity↑, 2,   toxicity↝, 3,   toxicity∅, 1,   TumVol↓, 3,   TumW↓, 2,  
Total Targets: 249

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 6,   ARE↑, 1,   Bil↑, 1,   Catalase↑, 2,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 3,   lipid-P↓, 3,   MDA↓, 2,   NQO1↑, 1,   NRF2↑, 4,   RNS↓, 2,   ROS↓, 10,   SOD↓, 1,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑cMyc↑, 1,   glucose↝, 1,   LDH↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bax:Bcl2↓, 1,   cl‑Casp8↑, 1,   iNOS↓, 2,   JNK↓, 1,   p‑MAPK↓, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 1,   other↑, 1,   other↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   GH↑, 1,   IGF-1R↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↓, 1,   MMP2↓, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hypoxia↓, 1,   PDGFR-BB↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   BBB∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   ICAM-1↓, 1,   IL1β↓, 1,   IL6↓, 3,   IL8↓, 2,   Inflam↓, 13,   JAK↓, 1,   NF-kB↓, 2,   NTF3/NT-3↑, 1,   PGE2↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   ChAT↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 17,   BioAv↝, 4,   BioEnh↑, 1,   BioEnh↝, 1,   Dose↝, 8,   Dose∅, 1,   eff↑, 4,   eff↝, 2,   Half-Life↓, 9,   Half-Life↑, 3,   Half-Life↝, 13,   Half-Life∅, 2,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Bil↑, 1,   BMD↑, 1,   BP↓, 1,   GutMicro↑, 3,   IL6↓, 3,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 3,   AntiTum↑, 1,   cardioP↑, 3,   chemoP↑, 3,   chemoPv↑, 1,   cognitive↑, 3,   hepatoP↓, 1,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 8,   radioP↑, 2,   RenoP↑, 2,   Sleep↑, 1,   toxicity↓, 4,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 2,  
Total Targets: 109

Scientific Paper Hit Count for: Half-Life, Half-Life
9 Curcumin
7 chitosan
7 Resveratrol
6 Boron
6 Chlorogenic acid
6 EGCG (Epigallocatechin Gallate)
6 Silymarin (Milk Thistle) silibinin
5 Auranofin
5 Artemisinin
5 Capsaicin
5 Fisetin
5 Pterostilbene
4 Alpha-Lipoic-Acid
4 Apigenin (mainly Parsley)
4 Aspirin
4 Berberine
4 Cucurbitacin
4 Dichloroacetate
4 Honokiol
4 HydroxyTyrosol
4 Isoliquiritigenin
4 Sulforaphane (mainly Broccoli)
4 Shikonin
4 Selenite (Sodium)
3 Allicin (mainly Garlic)
3 Ashwagandha(Withaferin A)
3 Baicalein
3 Betulinic acid
3 Chrysin
3 Quercetin
3 Propolis -bee glue
3 Piperlongumine
3 Urolithin
2 1,8-Cineole
2 borneol
2 Boswellia (frankincense)
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Ferulic acid
2 Deguelin
2 Disulfiram
2 Ellagic acid
2 Eurycomanone
2 Formononetin
2 Gambogic Acid
2 Huperzine A/Huperzia serrata
2 Isovitexin
2 Luteolin
2 Lycopene
2 Metformin
2 Phenethyl isothiocyanate
2 Rosmarinic acid
2 Thymoquinone
1 2-DeoxyGlucose
1 5-Hydroxytryptophan
1 Anthocyanins
1 Astragalus
1 Silver-NanoParticles
1 Acetyl-l-carnitine
1 Astaxanthin
1 Arsenic trioxide
1 Atorvastatin
1 Baicalin
1 Berbamine
1 Biochanin A
1 Bevacizumab (brand Avastin)
1 Chemotherapy
1 Bicalutamide
1 Bromelain
1 Vitamin D3
1 urea
1 Carvacrol
1 Catechins
1 Cannabichromene
1 Centella asiatica / Gotu kola → asiaticoside
1 cetuximab
1 Chocolate
1 Rutin
1 Crocetin
1 Caffeic acid
1 Dasatinib/Phyrago
1 Diclofenac
1 Dandelion Root
1 Copper and Cu NanoParticles
1 Echinacea
1 Ginkgo biloba-EGb 761
1 Eugenol
1 Fucoidan
1 Gallic acid
1 Gamma-aminobutyric acid
1 Garcinol
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Genistein (soy isoflavone)
1 Germanium inorganic
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 Gossypol/AT-101
1 Hydrogen Gas
1 HydroxyCitric Acid
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 High-Ozonide Oil
1 Hyperoside
1 Inositol
1 isoorientin
1 isoquercitrin
1 itraconazole
1 Vitexin
1 Juglone
1 Methylene blue
1 Methyl salicylate / Sweet Birch oil
1 Methylsulfonylmethane
1 Naringin
1 Niclosamide (Niclocide)
1 Oleuropein
1 Phenylbutyrate
1 Phosphatidylserine
1 immunotherapy
1 Rauwolfia serpentina/Indian Snakeroot
1 SonoDynamic Therapy UltraSound
1 Radiotherapy/Radiation
1 Thyme
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1109  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page