| Source: |
| Type: type of cell death |
| Type of programmed cell death dependent on iron. Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides to lethal levels. It is distinct from other forms of cell death, such as apoptosis, necrosis, and autophagy. The process of ferroptosis is heavily dependent on iron metabolism and reactive oxygen species (ROS). The accumulation of lipid peroxides is a hallmark of ferroptosis. This can occur when the antioxidant defenses, such as glutathione and selenoproteins, are overwhelmed or inhibited. Many cancer cells upregulate GPX4 to evade ferroptosis, making it a potential target for therapy. It has been described that GPX4, xCT and ACSL-4 are the main targets in the regulation of ferroptosis. |
| 2956- | PL, | Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis |
| - | in-vitro, | PC, | NA |
| 2958- | PL, | Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity |
| - | in-vitro, | Oral, | HSC3 |
| 2954- | PL, | The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy |
| - | Review, | Var, | NA |
| 4965- | PSO, | Cisplatin, | The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis |
| - | vitro+vivo, | GC, | HGC27 | - | vitro+vivo, | GC, | MKN45 |
| 5026- | QC, | Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes |
| - | in-vitro, | GC, | NA |
| 1489- | RES, | Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer |
| - | Review, | Var, | NA |
| 3023- | RosA, | Rosmarinic acid alleviates septic acute respiratory distress syndrome in mice by suppressing the bronchial epithelial RAS-mediated ferroptosis |
| - | in-vivo, | Sepsis, | NA |
| 3024- | RosA, | rmMANF prevents sepsis-associated lung injury via inhibiting endoplasmic reticulum stress-induced ferroptosis in mice |
| - | in-vivo, | Sepsis, | NA |
| 3039- | RosA, | Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs |
| - | in-vivo, | Nor, | NA | - | in-vivo, | Stroke, | NA |
| 4911- | Sal, | MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells |
| - | in-vitro, | Var, | DU145 |
| 5000- | Sal, | Salinomycin kills cancer stem cells by sequestering iron in lysosomes |
| - | vitro+vivo, | BC, | NA |
| 4904- | Sal, | CUR, | Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition |
| 5139- | SAS, | Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis |
| - | in-vitro, | OS, | MG63 | - | in-vitro, | OS, | U2OS |
| 5044- | SAS, | xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma |
| - | in-vitro, | Var, | NA |
| 5039- | SAS, | Regulatory network of ferroptosis and autophagy by targeting oxidative stress defense using sulfasalazine in triple-negative breast cancer |
| - | vitro+vivo, | BC, | NA |
| 4712- | Se, | Selenium and selenoproteins: key regulators of ferroptosis and therapeutic targets in cancer |
| - | Review, | Var, | NA |
| 1483- | SFN, | Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment |
| - | in-vitro, | OS, | 143B | - | in-vitro, | Nor, | HEK293 | - | in-vivo, | OS, | NA |
| - | in-vitro, | CRC, | HCT116 |
| 3313- | SIL, | Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats |
| - | in-vivo, | NA, | NA |
| 2201- | SK, | Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice |
| - | in-vitro, | PSA, | HaCaT | - | in-vivo, | NA, | NA |
| 2200- | SK, | Shikonin inhibits the growth of anaplastic thyroid carcinoma cells by promoting ferroptosis and inhibiting glycolysis |
| - | in-vitro, | Thyroid, | CAL-62 | - | in-vitro, | Thyroid, | 8505C |
| 2199- | SK, | Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis |
| - | in-vitro, | GC, | NA |
| 2198- | SK, | Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis |
| - | in-vitro, | OS, | MG63 | - | in-vitro, | OS, | 143B |
| 2195- | SK, | Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis |
| - | in-vitro, | OS, | NA |
| 2203- | SK, | Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation |
| - | in-vitro, | Lung, | NA |
| 2202- | SK, | Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification |
| - | in-vitro, | Var, | NA |
| 1284- | SK, | Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy |
| - | in-vitro, | Melanoma, | RPMI-8226 | - | in-vitro, | Melanoma, | U266 |
| 1068- | SM, | Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | MDA-MB-231 | - | in-vivo, | BC, | NA | - | Human, | BC, | NA |
| 4892- | Sper, | erastin, | Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer |
| - | in-vitro, | Pca, | PC3 | - | in-vivo, | Pca, | NA |
| 1002- | SSE, | Osi, | Adag, | Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference |
| - | in-vitro, | Lung, | H1975 | - | in-vitro, | Lung, | H385 |
| 4727- | SSE, | Selenium inhibits ferroptosis in ulcerative colitis through the induction of Nrf2/Gpx4 |
| - | in-vivo, | Col, | NA |
| 4723- | SSE, | Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4 |
| - | in-vitro, | CRC, | HCT116 |
| 4732- | SSE, | Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway |
| - | in-vivo, | Autism, | NA |
| 4718- | SSE, | High-Dose Selenium Induces Ferroptotic Cell Death in Ovarian Cancer |
| - | in-vitro, | Ovarian, | NA |
| 5091- | SSE, | Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite |
| - | in-vitro, | GBM, | U87MG | - | in-vitro, | Cerv, | HeLa | - | in-vitro, | BC, | MCF7 | - | in-vitro, | Pca, | PC3 | - | in-vitro, | CRC, | HT-29 | - | in-vitro, | Nor, | SVGp12 |
| 5088- | SSE, | Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | GBM, | U87MG | - | in-vitro, | Pca, | PC3 | - | in-vitro, | Cerv, | HeLa | - | in-vitro, | GBM, | A172 |
| 5333- | TFdiG, | Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts |
| - | vitro+vivo, | OS, | MG63 |
| 4869- | Uro, | Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges |
| - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | Stroke, | NA |
| 1216- | VitC, | Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer |
| - | in-vitro, | Laryn, | FaDu | - | in-vitro, | SCC, | SCC-154 |
| 1221- | Z, | Unexpected zinc dependency of ferroptosis: what is in a name? |
| - | Analysis, | Nor, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:114 State#:% Dir#:%
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