chemoP Cancer Research Results

chemoP, ChemoProtective: Click to Expand ⟱
Source:
Type:
Protects normal cells against the effect of Chemo.
Scientific Papers found: Click to Expand⟱
2519- H2,    Hydrogen: an advanced and safest gas option for cancer treatment
- Review, Var, NA
antiOx↑, neuroP↓, BBB↑, toxicity∅, TumCP↓, Apoptosis↓, ROS↑, Hif1a↓, NF-kB↓, P53?, OS↑, chemoP↑,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, Synergy↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
2508- H2,    Molecular hydrogen is a promising therapeutic agent for pulmonary disease
- Review, Var, NA - Review, Sepsis, NA
*ROS↓, eff↝, *Inflam↓, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *MPO↑, *ASK1↓, *NADPH↓, *Sepsis↓, *HMGB1↓, ROS↑, NLRP3↑, GSDMD↑, chemoP↑, eff↑, *antiAll↑,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
- Review, Var, NA
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2900- HNK,    The Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and Chemoresistance
- Review, Var, NA
SIRT3↑, Hif1a↓, ChemoSen↑, chemoP↑,
2889- HNK,  doxoR,    Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice
- in-vivo, Nor, NA
*SIRT3↑, chemoP↑, *cardioP↑, mtDam↑, ROS↑, *ROS↓, *MMP↑,
4636- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/ß-catenin and TGFß signaling
- in-vitro, BC, SUM159 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, BC, BT549
Wnt↓, β-catenin/ZEB1↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, TGF-β↓, CSCs↓, TumCMig↓, chemoP↑,
4634- HT,    Hydroxytyrosol in cancer research: recent and historical insights on discoveries and mechanisms of action
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, chemoP↑,
7568- HYP,  PacT,    Administration with hyperoside sensitizes breast cancer cells to paclitaxel by blocking the TLR4 signaling
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, selectivity↑, chemoP↑, TumCI↓, ChemoSen↑, tumCV↓, Apoptosis↑, Casp3↑, TLR4↓, NF-kB↓,
7643- Ins,  IP6,    Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical stud
- Trial, BC, NA
RBC↑, QoL↑, Synergy↑, Imm↑, ChemoSen↑, chemoP↑, Dose↝,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, Synergy↑,
7673- iod,  Chemo,    Adjuvant Effect of Molecular Iodine in Conventional Chemotherapy for Breast Cancer. Randomized Pilot Study
- Trial, BC, NA
Dose↝, *chemoP↑,
7681- iod,  mCHEMO,    Molecular Iodine Improves the Efficacy and Reduces the Side Effects of Metronomic Cyclophosphamide Treatment against Mammary Cancer Progression
- in-vivo, BC, NA
tumCV↓, Imm↑, chemoP↑, Weight↑, TumCG↓, VEGF↓, survivin↓, ChemoSen↑,
7640- IP6,  Ins,    Effects of Inositol Hexaphosphate and Myo-Inositol Administration in Breast Cancer Patients during Adjuvant Chemotherapy
- Trial, BC, NA
*antiOx↑, QoL↑, RBC↑, HemoG↑, WBC↑, chemoP↑, Dose↝,
7690- IP6,  Ins,    Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application
- Review, Colon, NA
AntiCan↑, Imm↑, antiOx↑, TumCP↓, Diff↑, TumCG↓, Synergy↑, P21↓, p27/CDKN1B↓, pRB↓, TumCCA↑, PI3K↓, Akt↓, PKCδ↓, RAS↓, ERK↓, NF-kB↓, Inflam↓, MMP9↓, IronCh↑, NK cell↑, selectivity↑, ChemoSen↑, chemoP↑, toxicity↓, Remission↑,
7705- IP6,    Inositol hexaphosphate (InsP6) as an effective topical treatment for patients receiving adjuvant chemotherapy after breast surgery
- Human, BC, NA
QoL↑, chemoP↑,
7790- ISL,    Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase
- vitro+vivo, BC, MCF7
CYP19↓, TumCG↓, Weight∅, chemoP↓,
7735- isoFl,    Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy
- Review, Var, NA
Risk↓, ChemoSen↑, chemoP↑, RadioS↑, radioP↑, NF-kB↓, DNMTs↓, TumMeta↓, angioG↓, antiOx↑, BioAv↑, toxicity↓,
7878- isoO,  Cisplatin,    Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway
- in-vivo, Nor, NA
*antiOx↑, *RenoP↑, *chemoP↑, *SIRT1↑, *SIRT6↑, *NRF2↑, *HO-1↑, *NQO1↑, *NOX4↓, *ROS↓, *MPO↓, *MDA↓, *SOD↑, *GSH↑,
7873- isoO,    Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways
- in-vitro, Liver, HepG2 - in-vitro, CRC, HT-29 - in-vitro, Lung, A549
ChemoSen↑, TumCP↓, chemoP↑, *ROS↓, *mtDam↓, *Apoptosis↓, *cardioP↑, *NRF2↑, *TGF-β↑, *p‑JNK↓, *p‑p38↓, *MAPK↝, *Akt↝, *STAT3↝,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
7791- ISQ,    Isoquercitrin: pharmacology, toxicology, and metabolism
- Review, Nor, NA
*BioAv↑, *chemoP↑, *ROS↓, *cardioP↑, *AntiDiabetic↑, *Dose↝, *antiAll↑,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
8249- LCA,    Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells
- in-vitro, NSCLC, NA
tumCV↓, LDH↑, Apoptosis↑, selectivity↑, LC3II↑, TumAuto↑, ER Stress↑, CHOP/DDIT3↑, chemoP↑, RenoP↑, cl‑PARP↑, cl‑Casp7↑, cl‑Casp3↑,
8239- LCA,    Licochalcone A, a licorice flavonoid: antioxidant, cytotoxic, genotoxic, and chemopreventive potential
- Study, Nor, NA
*chemoP↑,
8256- LCA,    Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity without a loss of chemotherapeutic efficacy in mice
- in-vivo, Colon, CT26
TumVol?, TumCP↓, *RenoP↑, *creat↓, BUN↓, hepatoP↑, *ALAT↓, *AST↓, *NO↓, *lipid-P↓, *GSH↑, chemoP↑, Dose↝,
8341- LDN,    Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy
- Review, Var, NA
OGFr↑, TumCP↓, TumCCA↑, Apoptosis↑, toxicity↝, Half-Life↝, *FasL↓, *Fas↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, survivin↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, ChemoSen↑, chemoP↑, Synergy↑, QoL∅,
8338- LDN,    Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway
- vitro+vivo, Cerv, HeLa - in-vitro, Cerv, SiHa
TumCP↓, TumCMig↓, TumCI↓, PI3K↓, p‑Akt↓, mTOR↓, OGFr↑, Dose↝, *toxicity↝, chemoP↑, ChemoSen↑,
8339- LDN,    Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells in vitro and effects indirectly on tumor-associated macrophages in vivo
- in-vivo, Cerv, HeLa
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, TAMS↓, M2 MC↓, IL10↓, OGFr↑, chemoP↑,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8273- LE,    A Systematic Review of the Effect of Licorice on Head and Neck Chemotherapy- and Radiotherapy-Induced Mucositis
- Review, HNSCC, NA
radioP↑, chemoP↑, *Pain↓, *Inflam↓, IL1β↓, PGE2↑, COX2/PTGS2↓, *toxicity↝, *Mucositis↓,
8277- LE,    Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights
- Review, Var, NA
*antiOx↑, *AntiTum↑, HMGB1↓, COX2/PTGS2↓, PGE2↓, TumCP↓, TumCCA↑, Synergy↑, MMP↓, p‑P53↑, BAX↑, cl‑PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, ROS↑, TumAuto↑, MMP9↓, TumMeta↓, PI3K↓, Akt↓, eff↑, *chemoP↑, *NRF2↑, *NF-kB↓,
8278- LE,    Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
- Review, Var, NA
*Ingr↝, *AntiCan↑, *AntiDiabetic↑, *AntiBio↑, *Inflam↓, *antiAll↑, *hepatoP↑, *cough?, *SoreThr?, *toxicity↝, *cardioP↑, *BioAv↝, *PGE2↓, *COX2/PTGS2↓, *AntiAg↑, *ROS↓, *NLRP3↓, *NF-kB↓, *AP-1↓, TumCCA↑, Apoptosis↑, TumMeta↑, *Dose↝, *Dose↝, Ingr↝, TumAuto↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, *cognitive↑, *BloodF↑, ChemoSen↑, ROS↓, *chemoP↑, ROS↑, tumCV↓, MMP↓, *AntiBio↑, *toxicity↝,
8129- LF,    Study on the Therapeutic Benefit on Lactoferrin in Patients with Colorectal Cancer Receiving Chemotherapy
- Trial, CRC, NA
Dose↝, toxicity↓, INF-γ↝, other↑, *ROS↓, Imm↑, WBC↑, Neut↑, T-Cell↑, *antiOx↑, *GSH↑, *chemoP↑, *RenoP↑, *hepatoP↑, BUN↓, creat↓, ALAT↓, AST↓, RBC↑, PC↑, Mucositis↓, *AntiBio↑, *AntiViral↑, *AntiFungal↑, *Inflam↓,
8292- lign,    Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives
- Review, Var, NA
*BioAv↝, chemoPv↑, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, *AntiDiabetic↑, *antiOx↑, *AntiCan↑, *Inflam↓, *cardioP↑, TumCCA↑, PSA↓, miR-106b↓, IGF-1↓, ERK↓, Akt↓, Bcl-2↓, p‑FAK↓, radioP↑, P-gp/ABCB1↓, ChemoSen↑, MMP↓, ROS↑, BioAv↓, *toxicity↓, chemoP↑,
8327- LIN,    Recent updates on bioactive properties of linalool
- Review, Var, NA
*AntiCan↑, *AntiBio↑, *neuroP↑, *Stress↓, *hepatoP↑, *RenoP↑, *ROS↓, ROS↑, *Inflam↓, *toxicity↓, TumCP↓, TumCCA↑, mtDam↑, MMP↓, compI↓, compII↓, ETC↓, ATP↓, angioG↓, ChemoSen↑, *GSH↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ALAT↓, *AST↓, chemoP↑,
8323- LIN,  doxoR,    Efficacy of Combination Therapy with Linalool and Doxorubicin Encapsulated by Liposomes as a Two-in-One Hybrid Carrier System for Epithelial Ovarian Carcinoma
- vitro+vivo, Ovarian, NA
ChemoSen↑, TumCG↓, Ki-67↓, CD31/PECAM-1↓, Casp3↑, *toxicity↓, chemoP↑, *BioAv↓, EPR↑,
8320- LIN,    Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways
- in-vivo, Nor, NA
RenoP↑, Dose↝, *TLR4↓, *MyD88↓, *TRIF↓, *TNF-α↓, *IL1β↓, *IL6↓, *NF-kB↓, *chemoP↑, *Casp3↓, *Casp9↓, *BAX↓, *Bcl-2↑, ChemoSen↑, *cardioP?, *hepatoP↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *ROS↓, *BUN?, *creat↓, *GSH↑, *SOD↑, *Catalase↑, *MDA↓, *NADPH↓, *NRF2↑, *HO-1↑,
8375- LT,    Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches
- Review, Var, NA
TumCP↓, TumCI↓, Apoptosis↑, TumCCA↑, Inflam↓, Ferroptosis↑, Pyro↑, ChemoSen↑, chemoP↑, *BioAv↓, OATPs↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2909- LT,    Revisiting luteolin: An updated review on its anticancer potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, TumCP↓, chemoP↑, MDR1↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
3533- Lyco,  Chemo,    Lycopene and chemotherapy toxicity
- Review, Var, NA
*ROS↓, *antiOx↑, *chemoP↑, *Inflam↓,
3279- Lyco,    The role of lycopene and its derivatives in the regulation of transcription systems: implications for cancer prevention
- Review, Var, NA
chemoP↑,
4781- Lyco,  5-FU,  Chemo,  Cisplatin,    Antioxidant and anti-inflammatory activities of lycopene against 5-fluorouracil-induced cytotoxicity in Caco2 cells
- in-vitro, Colon, Caco-2
chemoP↑, Inflam↓, COX2/PTGS2↓, IL1β↓, IL6↓, TNF-α↓, ROS↑, ChemoSen↑, SOD↓,
4788- Lyco,    Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)
- Review, Var, NA
AntiCan↑, ChemoSen↑, chemoP↑, Dose↝, BioAv↑, BioAv↑, BioAv↓, cardioP↑, AntiDiabetic↑, hepatoP↑, neuroP↑, MAPK↓, MMP2↓, MMP9↓, TIMP1↑, TIMP2↑,
4532- MAG,  Cisplatin,    Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation
- in-vivo, Var, NA
cachexia↓, *IGF-1↑, chemoP↑, *M2 MC↑,
8577- Matr,  Cisplatin,    Meta analysis of compound matrine injection combined with cisplatin chemotherapy for advanced gastric cancer
- Review, GC, NA
ChemoSen↑, QoL↑, chemoP↑,
2379- MET,    Down‐regulation of PKM2 enhances anticancer efficiency of THP on bladder cancer
- in-vitro, Bladder, T24/HTB-9 - in-vitro, BC, UMUC3
PKM2↓, p‑STAT3↓, TumCG↓, Synergy↑, chemoP↑, AMPK↑,

Showing Research Papers: 101 to 150 of 228
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 228

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 8,   antiOx⇅, 1,   Bil↝, 1,   Catalase↓, 2,   Catalase↑, 4,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 3,   GSH↓, 15,   GSH↑, 3,   GSH∅, 1,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 1,   i-H2O2↓, 1,   HO-1↓, 3,   HO-1↑, 3,   HO-2↑, 1,   i-Iron↓, 1,   c-Iron↑, 1,   lipid-P↓, 4,   lipid-P↑, 4,   MDA↓, 2,   MDA↑, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↓, 5,   NRF2↑, 6,   Prx6↑, 1,   PrxI↓, 1,   PrxI∅, 1,   PrxII↑, 1,   PrxII∅, 1,   ROS↓, 11,   ROS↑, 76,   ROS⇅, 6,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SOD↓, 3,   SOD↑, 3,   SOD2↓, 2,   Thiols↓, 1,   Trx↓, 1,   TrxR↑, 1,   uricA↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,   compI↓, 2,   compII↓, 1,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 1,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 5,   PGC-1α↑, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   5LO↓, 1,   ACSL4↑, 2,   ALAT↓, 4,   AMP↑, 1,   AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 4,   BHB↑, 1,   FASN↓, 3,   GLO-I↓, 1,   glucoNG↓, 1,   glucose↝, 1,   GlucoseCon↓, 1,   GlucoseCon∅, 1,   GlutMet↓, 1,   Glycolysis↓, 4,   GSK‐3β↓, 3,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 1,   H2S↑, 1,   HK2↓, 2,   HMG-CoA↓, 1,   HMGCS2↑, 1,   lactateProd∅, 1,   LDHA↓, 3,   lipoGen↓, 1,   NAD↑, 1,   NADPH↓, 1,   PCK1↓, 1,   PDK1 / PDPK1↓, 2,   PFK1↓, 1,   PKM2↓, 3,   PPP↓, 1,   SCD1↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 3,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 61,   m-Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 1,   BAD↑, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 29,   Bax:Bcl2↑, 3,   Bcl-2↓, 31,   Bcl-2↑, 1,   Bcl-xL↓, 8,   BIM↓, 1,   BIM↑, 1,   Casp↑, 19,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 30,   cl‑Casp3↑, 3,   proCasp3↑, 1,   Casp7↑, 4,   cl‑Casp7↑, 2,   Casp8↑, 7,   proCasp8↑, 1,   Casp9↓, 2,   Casp9↑, 17,   cl‑Casp9↑, 3,   proCasp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 21,   Cyt‑c↝, 1,   Diablo↑, 2,   DR5↑, 5,   Fas↓, 1,   Fas↑, 5,   FasL↓, 1,   FasL↑, 1,   Ferroptosis↑, 5,   GSDMD↑, 1,   IAP1↓, 4,   IAP2/BIRC3↓, 4,   iNOS↓, 6,   Mcl-1↓, 6,   p‑MDM2↓, 1,   MOMP↑, 1,   p38↓, 1,   p38↑, 6,   p‑p38↓, 3,   p‑p38↑, 2,   Pyro↑, 1,   survivin↓, 15,   TumCD↓, 1,   TumCD↑, 8,   XIAP↓, 7,   YAP/TEAD↓, 1,   YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 37,   Akt↑, 2,   p‑Akt↓, 7,   p‑Akt↑, 1,   cMET↓, 1,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 8,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 21,   p‑ERK↓, 3,   p‑ERK↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   IKKα↓, 1,   IκB↓, 1,   JAK↓, 2,   JAK1↓, 2,   JAK2↓, 1,   JNK↓, 2,   JNK↑, 4,   p‑JNK↓, 1,   p‑JNK↑, 3,   MAPK↓, 13,   MAPK↑, 4,   MEK↓, 2,   MKK4↓, 1,   mTOR↓, 15,   p‑mTOR↓, 1,   mTORC2↓, 1,   p42↓, 1,   p‑p70S6↑, 1,   PI3K↓, 30,   PI3K↑, 2,   p‑PI3K↓, 3,   PKCδ↓, 3,   PTEN↓, 1,   PTEN↑, 4,   Raf↓, 2,   e-Raf↓, 1,   RAS↓, 5,   RAS↑, 1,   Sp1/3/4↓, 1,   p‑Src↓, 1,   STAT↓, 2,   STAT3↓, 17,   p‑STAT3↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   ChrMod↑, 1,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 4,   cMyc↑, 1,   DNMT1↓, 1,   DNMT3B↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXO↑, 2,   FOXO1↑, 1,   H3↓, 1,   p‑H3↓, 1,   H4↓, 1,   HATs↑, 2,   HDAC↓, 10,   HDAC2↓, 1,   HDAC3↓, 1,   miR-106b↓, 1,   miR-124-3p↓, 1,   miR-203↑, 1,   miR-34a↑, 1,   Myc↑, 1,   MYCN↓, 1,   OCT4↓, 2,   other?, 1,   other↑, 2,   other↝, 10,   PhotoS↑, 2,   Prot↓, 1,   sonoS↑, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 5,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 7,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   IRE1∅, 1,   NQO2↑, 1,   p‑PERK↑, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3II↑, 5,   LC3s↑, 1,   p62↓, 1,   TumAuto↑, 8,   TumAuto↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↓, 1,   DNAdam↑, 18,   DNArepair↓, 1,   ERCC1↓, 1,   P53?, 1,   P53↓, 1,   P53↑, 21,   p‑P53↑, 2,   PARP↑, 5,   cl‑PARP↓, 1,   cl‑PARP↑, 19,   PCNA↓, 10,   Telomerase↓, 3,   TOP1↓, 2,   TOP2↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 2,   CDK1↑, 1,   CDK2↓, 5,   CDK4↓, 9,   CDK6↓, 2,   CDK6↑, 1,   CHK1↓, 1,   CHK1↑, 1,   Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 17,   cycE/CCNE↓, 4,   E2Fs↓, 1,   GADD34↑, 1,   GADD45A↑, 2,   Ki-67↓, 7,   mitA↑, 1,   P21↓, 1,   P21↑, 14,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 5,   pRB↓, 1,   p‑pRB↓, 2,   RB1↑, 1,   TumCCA↓, 2,   TumCCA↑, 53,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMPs↑, 1,   CD133↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 9,   Diff↑, 2,   FGF↓, 1,   HH↓, 1,   HH↝, 1,   IGF-1↓, 4,   IGFBP3↑, 1,   Ki-67↓, 7,   LRP6↓, 1,   mTORC1↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH1↓, 7,   OGFr↑, 3,   SCF↓, 1,   Shh↓, 1,   TumCG↓, 27,   TumCG↑, 1,   TumCP↓, 51,   TumCP↑, 3,   Wnt↓, 11,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 2,   AXL↓, 2,   BACH1↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 9,   Cav1↓, 1,   Cdc42↓, 1,   Cofilin↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 6,   EMT↓, 12,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 3,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 1,   ITGB1↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 20,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 21,   MMPs↓, 12,   N-cadherin↓, 6,   PDGF↓, 2,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 3,   TGF-β↓, 5,   TGF-β1↓, 1,   TIMP1↑, 5,   TIMP2↑, 2,   TumCI↓, 19,   TumCMig↓, 23,   TumMeta↓, 25,   TumMeta↑, 1,   Twist↓, 3,   Tyro3↓, 1,   uPA↓, 4,   Vim↓, 7,   Vim↑, 1,   Zeb1↓, 2,   β-catenin/ZEB1↓, 13,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32,   angioG↑, 1,   CD31/PECAM-1↓, 3,   HIF-1↓, 3,   Hif1a↓, 21,   LOX1↓, 1,   VCAM-1↓, 2,   VEGF↓, 30,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CellMemb↑, 1,   CLDN1↓, 1,   EPR↑, 2,   GastroP↑, 1,   GLUT1↓, 1,   GLUT2↓, 1,   MMP↓, 30,   NHE1↓, 1,   OATPs↓, 2,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↑, 1,   CD44↓, 2,   CD47↓, 1,   CD8+↑, 3,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 26,   CXCR4↓, 6,   DCells↑, 1,   HCAR2↑, 1,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 2,   IL10↑, 1,   IL12↑, 1,   IL1β↓, 10,   IL2↓, 1,   IL2↑, 4,   IL6↓, 15,   IL8↓, 3,   Imm↑, 16,   Imm↝, 1,   INF-γ↑, 1,   INF-γ↝, 1,   Inflam↓, 19,   Inflam↑, 2,   M2 MC↓, 1,   MDSCs↓, 1,   Neut↑, 2,   NF-kB↓, 45,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 5,   NLRP3↓, 3,   NLRP3↑, 2,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 4,   PD-L1↑, 1,   PGE2↓, 7,   PGE2↑, 1,   PSA↓, 5,   T-Cell↑, 1,   Th1 response↑, 1,   Th2↑, 1,   TLR4↓, 1,   TNF-α↓, 18,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↓, 1,   TrkB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CYP19↓, 1,   ER-α36↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 14,   BioAv↑, 18,   BioAv↝, 4,   chemoR↓, 1,   ChemoSen?, 1,   ChemoSen↑, 106,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 2,   CompStab↓, 2,   CYP1A1↓, 3,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↑, 9,   Dose↝, 43,   Dose∅, 1,   eff↓, 8,   eff↑, 32,   eff⇅, 1,   eff↝, 9,   eff∅, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 6,   MDR1↓, 4,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 6,   P450↓, 3,   RadioS↑, 23,   RadioS↝, 1,   selectivity↑, 38,   Synergy↑, 33,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 4,   ALP↓, 1,   AR↓, 2,   AST↓, 2,   Bil↝, 1,   BUN↓, 3,   CEA↓, 1,   creat↓, 3,   EGFR↓, 8,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   HemoG↑, 1,   HER2/EBBR2↓, 1,   IL6↓, 15,   LDH↑, 1,   e-LDH↑, 1,   Myc↑, 1,   NSE↓, 1,   PC↑, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 5,   RBC↑, 3,   Verbal↑, 1,   WBC↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 23,   AntiCan∅, 1,   AntiDiabetic↑, 1,   antiNeop↑, 1,   AntiTum↑, 12,   Appetite↑, 2,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 2,   cardioP↑, 10,   chemoP?, 1,   chemoP↓, 3,   chemoP↑, 181,   chemoP↝, 1,   chemoP∅, 1,   chemoPv↑, 5,   ChemoSideEff↓, 4,   cognitive↑, 2,   fatigue↓, 1,   fatigue∅, 1,   hepatoP↑, 17,   hepatoP∅, 1,   memory↑, 1,   Mucositis↓, 1,   Nausea↓, 1,   neuroP↓, 1,   neuroP↑, 7,   NP/CIPN↓, 3,   OS↓, 2,   OS↑, 12,   OS⇅, 1,   Pain↓, 7,   PFS↑, 1,   QoL↑, 20,   QoL∅, 2,   radioP↑, 29,   radioP↝, 1,   Remission↑, 1,   RenoP↑, 9,   RenoP∅, 1,   Risk↓, 19,   Risk↑, 2,   Risk⇅, 1,   Sleep↑, 2,   Strength↑, 2,   toxicity↓, 11,   toxicity↑, 1,   toxicity↝, 4,   toxicity∅, 2,   TumVol?, 1,   TumVol↓, 10,   TumVol↑, 1,   TumW↓, 1,   Weight↑, 5,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 4,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 608

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 60,   ARE↑, 1,   Catalase↑, 24,   Copper↓, 1,   Fenton↓, 2,   GPx↑, 23,   GPx1↑, 1,   GPx4↓, 1,   GPx4↑, 1,   GSH↑, 28,   GSR↑, 4,   GSTs↑, 9,   H2O2↓, 1,   HDL↑, 2,   HO-1↓, 2,   HO-1↑, 21,   Iron↓, 2,   Iron↑, 1,   Keap1↓, 2,   Keap1↝, 1,   lipid-P↓, 18,   MDA↓, 18,   MDA↑, 1,   MPO↓, 6,   MPO↑, 2,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 2,   NQO1↑, 3,   NRF2↑, 39,   RNS↓, 3,   ROS↓, 67,   ROS↝, 1,   ROS∅, 2,   mt-ROS?, 1,   SAM-e↑, 1,   selenoP↑, 2,   SOD↑, 34,   SOD1↑, 3,   SOD2↑, 2,   TAC↑, 1,   TBARS↓, 2,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   FIS1↓, 1,   Insulin↓, 1,   Insulin↑, 1,   MFN2↑, 2,   mtDam↓, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   PINK1↑, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 1,   ACC↓, 1,   Acetyl-CoA↓, 1,   adiP↑, 1,   ALAT↓, 9,   AMPK↑, 5,   ATP↑, 4,   ATP↝, 1,   CRM↓, 1,   FABP4↓, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   glucose↓, 4,   glucose↝, 1,   GlucoseCon↑, 1,   GSK‐3β↑, 1,   H2S↑, 1,   KeyT↝, 1,   LDL↓, 4,   NAD↝, 1,   NADPH↓, 4,   NADPH↑, 1,   PLA2↓, 1,   SIRT1↑, 4,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 10,   ASK1↓, 1,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp12↓, 1,   Casp3↓, 12,   cl‑Casp8↑, 1,   Casp9↓, 5,   Cyt‑c↓, 1,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   iNOS↓, 8,   necrosis↓, 1,   p38↓, 2,   p‑p38↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 5,   Akt↝, 1,   AMPKα↑, 1,   ERK↓, 2,   IGF-1R↓, 1,   IKKα↑, 1,   IκB?, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 1,   p‑JNK↓, 2,   MAPK↓, 2,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 3,   p‑mTOR↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 2,   PI3K↑, 2,   PKCδ?, 1,   PKCδ↓, 1,   PTEN↓, 1,   STAT3↓, 1,   STAT3↑, 1,   STAT3↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF2↑, 1,   ATF4↓, 1,   FOXO3↑, 1,   HDAC↑, 1,   miR-34a↓, 1,   other?, 2,   other↓, 5,   other↑, 10,   other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   p‑eIF2α↓, 1,   ER Stress↓, 3,   GRP78/BiP↓, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   MitoP↓, 1,   p62↑, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   DNArepair↑, 1,   P53↓, 3,   P53↑, 1,   PARP1↓, 1,   PCNA↑, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,   GADD45A↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CEBPA↓, 1,   EP2↓, 1,   HH↓, 1,   IGF-1↑, 1,   mTORC1↓, 1,   neuroG↑, 1,   p300↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 5,   AP-1↓, 3,   Ca+2↓, 1,   Ca+2↝, 2,   Cartilage↑, 1,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMPs↓, 1,   p‑Rac1↓, 1,   serineP↓, 1,   TGF-β↓, 1,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   uPA↑, 1,   Vim↓, 1,   α-SMA↓, 1,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↑, 1,   NO↓, 5,   VCAM-1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   BBB∅, 1,   GastroP↑, 1,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   IBI↑, 1,   memfluid↑, 1,   MMP↑, 5,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 15,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 2,   IFN-γ↓, 2,   IL10↓, 4,   IL10↑, 5,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 13,   IL2↓, 1,   IL4↓, 3,   IL4↑, 2,   IL6↓, 23,   IL8↓, 2,   Imm↑, 6,   Imm↝, 1,   Inflam↓, 64,   LPS↓, 2,   M2 MC↑, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 3,   MyD88↓, 1,   NF-kB↓, 20,   NLRP3↓, 4,   PGE2↓, 7,   TLR4↓, 3,   TNF-α↓, 27,   Treg lymp↝, 1,   TRIF↓, 1,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 4,   BChE↓, 2,   BDNF↑, 2,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 1,   TrkB↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 2,   BACE/β-secretase↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   BNP↓, 1,   NR1H4↑, 1,   PPARγ↓, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 19,   BioAv↑, 21,   BioAv↝, 14,   BioEnh↑, 2,   ChemoSen↑, 1,   CYP3A2↓, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 2,   Dose↝, 14,   eff↑, 9,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 8,   P-gp/ABCB1↓, 2,   selectivity↑, 3,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9,   ALB↝, 1,   ALP↓, 3,   AST↓, 12,   BloodF↑, 1,   BMD↑, 3,   BP↓, 4,   BUN?, 1,   BUN↓, 4,   Calcium↑, 1,   creat↓, 9,   hs-CRP↓, 1,   IL6↓, 23,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 4,   Mag↑, 1,   NOS2↓, 1,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 1,   TMAO↓, 1,   Urea↓, 2,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll↑, 8,   AntiArt↑, 1,   AntiCan↑, 10,   AntiDiabetic↓, 1,   AntiDiabetic↑, 11,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP?, 2,   cardioP↑, 25,   chemoP↑, 46,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↓, 1,   cognitive↑, 11,   cough?, 1,   hepatoP↓, 1,   hepatoP↑, 25,   memory↑, 5,   motorD↑, 1,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 28,   Obesity↓, 8,   OS↑, 4,   Pain↓, 4,   QoL↑, 1,   radioP↑, 8,   RenoP↑, 15,   Risk↓, 1,   SoreThr?, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 5,   toxicity↓, 24,   toxicity↑, 1,   toxicity↝, 9,   toxicity∅, 1,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↑, 3,   AntiViral↑, 5,   Bacteria↓, 8,   Diar↓, 1,   GutMicro↑, 9,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 2,   Ingr↝, 2,  
Total Targets: 360

Scientific Paper Hit Count for: chemoP, ChemoProtective
21 Chemotherapy
14 Cisplatin
11 Silymarin (Milk Thistle) silibinin
10 Hydrogen Gas
9 Selenium
8 doxorubicin
8 Selenite (Sodium)
7 Curcumin
7 Thymoquinone
6 Melatonin
5 Allicin (mainly Garlic)
5 Anti-oxidants
5 Radiotherapy/Radiation
5 phytic acid, Inositol hexakisphosphate
4 Astragalus
4 Quercetin
4 Fucoidan
4 Honokiol
4 Inositol
4 Licorice
4 Luteolin
4 Lycopene
4 Morin
3 Ashwagandha(Withaferin A)
3 Astaxanthin
3 Paclitaxel/Taxol
3 Coenzyme Q10
3 EGCG (Epigallocatechin Gallate)
3 diet Short Term Fasting
3 Dandelion Root
3 HydroxyTyrosol
3 isoorientin
3 Licochalcone A
3 low dose naltrexone
3 Linalool
3 Magnetic Fields
3 Urolithin
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 beta-glucans
2 Brucea javanica
2 brusatol
2 Boron
2 Butyrate
2 Propolis -bee glue
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Chrysin
2 Garcinol
2 Docosahexaenoic Acid
2 Ellagic acid
2 Fisetin
2 Flaxseed/Linseed
2 Shilajit/Fulvic Acid
2 iodine
2 5-fluorouracil
2 Metformin
2 Oleuropein
2 Rosmarinic acid
2 Rutin
2 Selenium NanoParticles
1 Silver-NanoParticles
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Anethole/trans-Anethole
1 Atorvastatin
1 immunotherapy
1 Baicalein
1 Berberine
1 Gold NanoParticles
1 Beta-Caryophyllene
1 Betulinic acid
1 Bromelain
1 α-Bisabolol / Chamomile oil
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Cat’s Claw
1 Chlorogenic acid
1 Chlorophyllin
1 Chocolate
1 Vitamin E
1 Calorie Restriction Mimetics
1 HydroxyCitric Acid
1 Crocetin
1 diet Plant based
1 Diindolylmethane
1 Indole-3-carbinol
1 Lemongrass Extract/Citral
1 Disulfiram
1 Copper and Cu NanoParticles
1 Echinacea
1 Docetaxel
1 Emodin
1 Eugenol
1 Exercise
1 Formononetin
1 carboplatin
1 Gallic acid
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Hyperoside
1 MCT, metronomic chemo
1 Isoliquiritigenin
1 isoflavones
1 isoquercitrin
1 Kaempferol
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Magnolol
1 Matrine
1 Magnetic Field Rotating
1 Moringa oleifera
1 Methylsulfonylmethane
1 Naringin
1 Aidi injection
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Piperine
1 Psoralidin
1 benzo(a)pyrene
1 buckwheat sprouts
1 irinotecan
1 Sulforaphane (mainly Broccoli)
1 Shikonin
1 Squalene
1 Vitexin
1 Isovitexin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1171  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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