RenoP Cancer Research Results

RenoP, K,Renoprotection/Nephroprotective: Click to Expand ⟱
Source:
Type:
Protects kidneys
-Same as nephroprotective
Opposite is : Nephrotoxicity is toxicity in the kidneys
Scientific Papers found: Click to Expand⟱
8434- OM,    Traditional use, phytochemistry, toxicology, and pharmacology of Origanum majorana L
- Review, Var, NA
*Bacteria↓, *AntiFungal↑, *antiOx↑, *AntiP↑, *AntiDiabetic↑, *AntiCan↑, *RenoP↑, *Inflam↓, *Analgesic↑, *antiPy↑, *antiM↑, *Ingr↝, *Ingr↝, *creat↓, *Urea↓, *uricA↓, *BUN↓, *ALAT↓, *AST↓, *ALP↓, *Catalase↑, *SOD↑, *GSTA1↑,
3259- PBG,    Propolis and its therapeutic effects on renal diseases: A review
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *NO↓, *NF-kB↓, TumCP↓, angioG↓, VEGF↓, STAT↓, Hif1a↓, RenoP↑, TLR4↓, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *toxicity∅,
3348- QC,    Quercetin and iron metabolism: What we know and what we need to know
- Review, Var, NA
*IronCh↑, *ROS↓, *AntiAg↑, *Fenton↓, *lipid-P↓, *hepatoP↑, *RenoP↑, HIF-1↑, ROS↑,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2/PTGS2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
3059- RES,    Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury
- in-vivo, Nor, HK-2
*RenoP↑, *Inflam↓, *NRF2↑, *HO-1↑, *SIRT1↑, *ROS↓, AntiAge↑,
1747- RosA,    Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review
- Review, BC, MDA-MB-231 - Review, BC, MDA-MB-468
TumCCA↑, TNF-α↑, GADD45A↑, BNIP3↑, survivin↓, Bcl-2↓, BAX↑, HH↓, Synergy↑, ChemoSen↑, RadioS↑, TumCP↓, TumCMig↓, Apoptosis↑, RenoP↑, CardioT↓,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
4602- SeNPs,  AgNPs,  GoldNP,    Advances in nephroprotection: the therapeutic role of selenium, silver, and gold nanoparticles in renal health
- Review, Var, NA
*ROS↓, *RenoP↑, *Inflam↓,
4450- SeNPs,    Functionalized selenium nanoparticles with nephroprotective activity, the important roles of ROS-mediated signaling pathways
- in-vitro, Kidney, NA
antiOx↑, *ROS↓, RenoP↑,
4445- SeNPs,  DFE,    A comparative study on the hepatoprotective effect of selenium-nanoparticles and dates flesh extract on carbon tetrachloride induced liver damage in albino rats
- in-vivo, LiverDam, NA
*hepatoP↑, *antiOx↑, *AntiCan↑, *BioAv↑, *toxicity↓, *ROS↓, *MDA↓, *ALAT↓, *ALB↑, *GSH↑, *SOD↑, *RenoP↑,
3191- SFN,    Sulforaphane exhibits potent renoprotective effects in preclinical models of kidney diseases: A systematic review and meta-analysis
- Review, Nor, NA
*Prot↝, *RenoP↑, *creat↓,
3313- SIL,    Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *creat↓, *BUN↓, *RenoP↑, *MDA↓, *TNF-α↓, *IL1β↓, *Cyt‑c↓, *Casp3↓, *GSTs↓, *GSH↑, *GPx4↑, *SOD↑, *GSR↓, *Ferroptosis↓,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, Var, NA
*P-gp/ABCB1↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
2415- SK,    Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways
- in-vivo, Arthritis, NA
Apoptosis?, TumAuto↑, ROS↑, ATP↓, Glycolysis↓, PI3K↓, Akt↓, mTOR↓, *Apoptosis↓, *Inflam↓, *TNF-α↓, *IL6↓, *IL8↓, *IL10↓, *IL17↓, *hepatoP↑, *RenoP↑, PKM2↓, GLUT1↓, HK2↓,
2220- SK,    Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *SIRT1↓, *NRF2↑, *HO-1↑, *GSH↑, *TAC↑, *SOD↑, *MDA↓, *NO↓, *iNOS↓, *NHE3↑, *PI3K↑,
2217- SK,    Shikonin Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis to Attenuate Renal Ischemia/Reperfusion Injury by Activating the Sirt1/Nrf2/HO-1 Pathway
- in-vivo, Nor, NA - in-vitro, Nor, HK-2
*ER Stress↓, *SIRT1↑, *NRF2↑, *HO-1↑, *eff↓, *RenoP↑, *GRP78/BiP↓, *CHOP/DDIT3↓, *Casp12↓, *BAX↓, *cl‑Casp3↓,
5094- SSE,  Matr,    Sodium Selenite Prevents Matrine-Induced Nephrotoxicity by Suppressing Ferroptosis via the GSH-GPX4 Antioxidant System
- vitro+vivo, Nor, NRK52E
*GPx4↑, *xCT/SLC7A11↑, *GSH↑, *RenoP↝, *Ferroptosis↓,
2113- TQ,    Potential role of Nigella sativa (NS) in abating oxidative stress-induced toxicity in rats: a possible protection mechanism
- in-vivo, Nor, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *SOD↑, *GSH↑, *ROS↓, *lipid-P↓, ALAT↓, creat↓,
2118- TQ,  Rad,    In vivo radioprotective effects of Nigella sativa L oil and reduced glutathione against irradiation-induced oxidative injury and number of peripheral blood lymphocytes in rats
- in-vivo, Nor, NA
*ROS↓, RenoP↑, hepatoP↑,
2119- TQ,    Dual properties of Nigella Sativa: anti-oxidant and pro-oxidant
- Review, Var, NA
*ROS↓, ROS↑, chemoP↑, RenoP↑, hepatoP↑, NLRP3↓, neuroP↑, NF-kB↓, P21↑, HDAC↓, Apoptosis↑, TumCP↓, GSH↓, GADD45A↑, GSK‐3β↑,
2122- TQ,    Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
- Review, Var, NA
ChemoSen↓, *ROS↓, *GSH↑, RenoP↑, hepatoP↑, COX2/PTGS2↓, NF-kB↓, chemoPv↑, neuroP↑, TumCCA↑, P21↑, p27/CDKN1B↑, ROS↑, DNAdam↑, MUC4↓,
2126- TQ,    Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway
- Review, Nor, NA
*antiOx↑, *Bacteria↓, *RenoP↑, *hepatoP↑, *neuroP↑, *Inflam↓, *Keap1↓, *NRF2↑, *other↝,
2133- TQ,  CUR,  Cisplatin,    Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signalling
- in-vitro, Nor, HEK293 - in-vivo, NA, NA
*creat↓, *TNF-α↓, *IL6↓, *MRP↓, *GFR↑, *mt-ATPase↑, *p‑Akt↑, *NRF2↑, *HO-1↑, *Casp3↓, *NF-kB↓, *RenoP↑,
2111- TQ,  MTX,    Effect of Nigella sativa (black seeds) against methotrexate-induced nephrotoxicity in mice
- in-vivo, Nor, NA
*RenoP↑, *GSH↑,
3407- TQ,    Thymoquinone and its pharmacological perspective: A review
- Review, Var, NA
*antiOx↑, *ROS↓, *GSTs↑, *GSR↑, *GSH↑, *RenoP↑, *IL1β↓, *TNF-α↓, *MMP13↓, *COX2/PTGS2↓, *PGE2↓, *radioP↑, Twist↓, EMT↓, NF-kB↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, DNMT1↓, HDAC↓,
3400- TQ,  Chemo,    Thymoquinone Ameliorates Carfilzomib-Induced Renal Impairment by Modulating Oxidative Stress Markers, Inflammatory/Apoptotic Mediators, and Augmenting Nrf2 in Rats
- in-vitro, Nor, NA
*GSH↑, *SOD↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *Casp3↓, *Catalase↑, *NRF2↑, *RenoP↑,
3398- TQ,  5-FU,    Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo
- in-vivo, Nor, NA
*RenoP↑, *TAC↑, *ROS↓, *lipid-P↓, *p38↓, *MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *MDA↓, *GPx↑, *GSR↑, *Catalase↑, *BUN↓, *LDH↓, *IL1β↓,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27/CDKN1B↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, Synergy↑, DNAdam↑, *iNOS↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2/PTGS2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *BioAv↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑, *chemoP↑,
7887- VT,  IVT,    Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,

Showing Research Papers: 101 to 134 of 134
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 134

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 2,   Catalase↑, 2,   GSH↓, 4,   GSH↑, 1,   GSR↑, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 1,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 2,   ROS↓, 5,   ROS↑, 23,   i-ROS↑, 1,   mt-ROS↑, 1,   SOD↓, 2,   SOD↑, 2,   TAC↓, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 4,   compI↓, 1,   compII↓, 1,   ETC↓, 1,   mitResp↓, 1,   mtDam↑, 1,   mt-OXPHOS↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 3,   ATP↓, 2,   BHB↑, 1,   GlucoseCon↓, 2,   Glycolysis↓, 4,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   HK2↓, 3,   HMGCS2↑, 1,   lactateProd↓, 1,   LDHA↓, 1,   LDL↓, 1,   NADPH↑, 1,   PCK1↓, 1,   PDK1 / PDPK1↓, 2,   PKM2↓, 1,   SCD1↓, 1,   SIRT1↑, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 1,   Apoptosis?, 2,   Apoptosis↑, 21,   BAD↑, 1,   Bak↓, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 15,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 3,   Bcl-2↓, 15,   Bcl-xL↓, 4,   BID↑, 1,   BNIP3↑, 2,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 10,   cl‑Casp3↑, 3,   cl‑Casp7↑, 1,   Casp8↑, 7,   Casp9↑, 7,   cl‑Casp9↑, 4,   cFLIP↓, 1,   Cyt‑c↑, 12,   Diablo↑, 1,   DR5↑, 4,   FADD↑, 1,   Fas↑, 4,   FasL↑, 1,   HEY1↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 2,   iNOS↓, 2,   Mcl-1↓, 2,   MDM2↓, 1,   p38↑, 1,   p‑p38↓, 1,   PUMA↑, 1,   survivin↓, 3,   TumCD↑, 2,   XIAP↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 18,   Akt↑, 1,   p‑Akt↓, 3,   cMET↓, 1,   p‑cMET↑, 1,   EGFR↓, 3,   EGFR↑, 1,   ERK↓, 7,   p‑ERK↓, 1,   HER2/EBBR2↓, 2,   JAK1↓, 1,   JNK↑, 1,   LIMK1↓, 1,   MAPK↓, 5,   MAPK↑, 2,   mTOR↓, 6,   mTOR↑, 1,   mTORC2↓, 2,   P70S6K↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 10,   p‑PI3K↓, 2,   PKCδ↓, 1,   PTEN↑, 1,   RAS↓, 2,   RAS↑, 1,   SHP1↑, 1,   STAT↓, 1,   STAT3↓, 6,   p‑STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 2,   cMyc↓, 5,   DNMT1↓, 3,   DNMT3A↓, 1,   EZH2↓, 1,   FOXO3↑, 1,   H3↑, 1,   p‑H3↓, 1,   HDAC↓, 5,   HDAC1↓, 1,   HDAC4↓, 1,   miR-124-3p↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   MYCN↓, 1,   OCT4↓, 1,   other↓, 1,   other↑, 1,   SOX2↓, 1,   tumCV?, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 2,   HSP90↓, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↑, 2,   LC3II↑, 3,   LC3s↑, 1,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   DNAdam↑, 7,   hTERT/TERT↓, 2,   P53↑, 10,   PARP↑, 4,   cl‑PARP↑, 4,   PARP1↑, 1,   PCNA↓, 4,   TOP1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 3,   CDK4↓, 6,   CDK6↑, 1,   CHK1↓, 1,   CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 7,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   GADD45A↑, 2,   Ki-67↓, 4,   P21↓, 1,   P21↑, 8,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 3,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↑, 20,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 1,   CSCs?, 1,   CSCs↓, 2,   Diff↑, 2,   FGF↓, 1,   HH↓, 1,   Ki-67↓, 4,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↑, 3,   Shh↓, 1,   TumCG↓, 4,   TumCP↓, 18,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   Ca+2↑, 6,   E-cadherin↓, 1,   E-cadherin↑, 3,   EMT↓, 8,   EMT↑, 1,   FAK↓, 2,   Fibronectin↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 7,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 8,   MMP9↑, 1,   MMPs↓, 5,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 2,   PDGF↓, 1,   Rho↓, 3,   ROCK1↓, 1,   Slug↓, 2,   Smad1↑, 1,   Snail↓, 2,   TET1↑, 3,   TGF-β↓, 1,   TIMP2↓, 1,   TIMP2↑, 1,   TumCI↓, 7,   TumCMig↓, 7,   TumMeta↓, 5,   Twist↓, 5,   uPA↓, 4,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 12,   HIF-1↑, 1,   Hif1a↓, 8,   TBXAS1/TxAS↓, 1,   VEGF↓, 12,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   GLUT1↓, 1,   MMP↓, 11,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD44↓, 1,   CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 9,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   DR4↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 1,   IL10↓, 1,   IL1β↓, 4,   IL1β↑, 1,   IL6↓, 5,   IL8↓, 1,   Imm↑, 2,   INF-γ↝, 1,   Inflam↓, 4,   MCP1/CCL2↓, 2,   Neut↑, 1,   NF-kB↓, 21,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 1,   PD-1↓, 1,   PD-L1↓, 3,   PGE2↓, 5,   PSA↓, 1,   T-Cell↑, 1,   TLR4↓, 3,   TNF-α↓, 6,   TNF-α↑, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER-α36↓, 1,   PPARα↓, 1,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 4,   BioAv↑, 4,   BioAv↝, 1,   CBR1↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 17,   ChemoSen∅, 1,   CompStab↑, 1,   Dose↑, 1,   Dose↝, 13,   eff?, 1,   eff↑, 9,   eff↝, 2,   Half-Life↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 2,   RadioS↑, 4,   selectivity↑, 7,   Synergy↑, 18,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AST↓, 2,   BRCA1↑, 1,   BUN↓, 3,   CEA↓, 1,   creat↓, 4,   E6↓, 1,   E7↓, 1,   EGFR↓, 3,   EGFR↑, 1,   EZH2↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 2,   IL6↓, 5,   LDH↓, 2,   LDH↑, 1,   Maspin↑, 1,   PC↑, 1,   PD-L1↓, 3,   PSA↓, 1,   RBC↑, 1,   Urea↓, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 7,   AntiTum↑, 6,   cardioP↑, 4,   CardioT↓, 1,   chemoP↑, 16,   chemoPv↑, 3,   GFR↑, 1,   hepatoP↑, 9,   hepatoP∅, 1,   Mucositis↓, 2,   neuroP↑, 7,   NP/CIPN↓, 1,   NP/CIPN↑, 1,   Pain↓, 1,   PFS↑, 1,   QoL↑, 3,   radioP↑, 3,   RenoP↓, 1,   RenoP↑, 33,   RenoP∅, 1,   Risk↓, 1,   toxicity↓, 3,   toxicity↝, 2,   TumVol?, 1,   TumVol↓, 1,   TumW↓, 1,   Weight?, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 380

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 50,   ARE↑, 1,   Bil↓, 1,   Bil↑, 1,   Catalase↑, 30,   Copper↓, 1,   Fenton↓, 3,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 1,   GPx↑, 16,   GPx4↑, 3,   GSH↑, 39,   GSR↓, 1,   GSR↑, 5,   GSTs↓, 1,   GSTs↑, 8,   H2O2↓, 2,   HDL↑, 3,   HO-1↓, 1,   HO-1↑, 27,   HO-1⇅, 1,   Iron↓, 2,   Iron∅, 1,   Keap1↓, 3,   Keap1↑, 1,   lipid-P↓, 28,   MDA↓, 35,   MPO↓, 5,   NADH↓, 1,   NOX4↓, 2,   NQO1↑, 4,   NQO1↝, 1,   NRF2↓, 2,   NRF2↑, 37,   Prx↑, 1,   RNS↓, 1,   ROS↓, 80,   ROS⇅, 1,   ROS∅, 1,   SOD?, 1,   SOD↑, 39,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 1,   Trx1↑, 1,   UCPs↑, 1,   uricA↓, 5,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   MFN2↑, 2,   mtDam↓, 2,   PGC-1α↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   ALAT↓, 19,   ALAT∅, 1,   AMPK↑, 4,   p‑AMPK↑, 1,   ATP↑, 5,   Buty↑, 1,   cAMP↑, 1,   CRM↑, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↑, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 1,   HMG-CoA↓, 1,   KeyT↝, 1,   LDL↓, 6,   lipidLev↓, 2,   NADPH↓, 4,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 7,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 16,   ASC↓, 2,   BAX↓, 8,   Bax:Bcl2↓, 1,   Bcl-2↑, 7,   Casp1↓, 2,   Casp12↓, 3,   Casp3?, 1,   Casp3↓, 15,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 5,   Casp9∅, 1,   Cyt‑c↓, 3,   Cyt‑c∅, 1,   Fas↓, 2,   Ferroptosis↓, 7,   GranB/GZMB↓, 1,   iNOS↓, 13,   iNOS↑, 2,   p38↓, 4,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 5,   p‑Akt↑, 2,   ERK↓, 4,   ERK↑, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↑, 1,   JAK2↓, 1,   JNK↓, 4,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 8,   MAPK↑, 1,   p‑MAPK↓, 1,   mTOR↓, 3,   mTOR↑, 1,   PI3K↓, 4,   PI3K↑, 4,   PKCδ?, 1,   STAT3↓, 2,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF2↑, 1,   ATF4↓, 1,   cMyc↓, 1,   DNMT1↓, 2,   DNMTs↓, 1,   FOXO3↑, 1,   KLF4↑, 1,   other↓, 1,   other↑, 4,   other↝, 2,   other∅, 1,   Prot↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 3,   GRP78/BiP↑, 1,   GRP94↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   MitoP↓, 1,   p62↓, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   DNArepair↑, 1,   p16↓, 1,   P53↓, 2,   PARP∅, 1,   PARP1↓, 1,   PCNA↓, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HH↓, 1,   IGF-1↑, 1,   IGFBP1↑, 1,   neuroG↑, 1,   TumCP↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 2,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2↓, 1,   Ca+2↝, 2,   Cartilage↑, 2,   COL1↓, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MMP13↓, 2,   MMP9↓, 1,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TGF-β1↓, 1,   TumCI↓, 1,   TXNIP↓, 1,   α-SMA↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

eNOS↑, 1,   Hif1a↓, 1,   NO↓, 9,   VCAM-1↓, 4,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   BBB↝, 1,   GastroP↑, 4,   GLUT2↑, 1,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   IBI↑, 4,   MMP↑, 6,   NHE3↑, 1,   TJ↑, 1,   TRPV1↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 21,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 3,   IL1↓, 2,   IL10↓, 6,   IL10↑, 3,   IL12↓, 1,   IL17↓, 1,   IL18↓, 2,   IL1β↓, 23,   IL2↓, 2,   IL4↓, 3,   IL5↓, 1,   IL6↓, 26,   IL6↑, 2,   IL8↓, 6,   Imm↑, 5,   Inflam↓, 56,   Inflam↑, 1,   IRF3↓, 2,   LPS↓, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   MyD88↓, 4,   NeuroI↓, 1,   NF-kB↓, 27,   NLRP3↓, 7,   PGE2↓, 5,   RAGE↓, 2,   RANTES↓, 1,   TLR2↓, 3,   TLR4↓, 9,   TNF-α↓, 38,   TRIF↓, 2,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 7,   BChE↓, 3,   BDNF↑, 3,   ChAT↑, 1,   GABA↑, 1,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 1,   Aβ↓, 10,   BACE/β-secretase↓, 4,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 2,   ACE2↓, 1,   GLP-1R↑, 1,   NR1H4↑, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 16,   BioAv↑, 18,   BioAv↝, 5,   ChemoSen↑, 2,   Dose↝, 14,   eff↓, 1,   eff↑, 11,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 5,   MRP↓, 1,   P-gp/ABCB1↓, 2,   selectivity↑, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 19,   ALAT∅, 1,   ALB↑, 1,   ALB↝, 1,   ALP↓, 5,   AST↓, 19,   AST∅, 1,   BG↓, 2,   Bil↓, 1,   Bil↑, 1,   BloodF↑, 2,   BMD↑, 2,   BP↓, 4,   BUN?, 1,   BUN↓, 10,   CCr / CrCl↓, 1,   CCr / CrCl∅, 1,   creat↓, 20,   CRP↓, 1,   IL6↓, 26,   IL6↑, 2,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 4,   NOS2↓, 1,   RAGE↓, 2,   Urea↓, 5,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 2,   antiAll↑, 2,   AntiArt↑, 3,   AntiCan↑, 8,   antiD↓, 1,   AntiDiabetic↑, 11,   antiM↑, 1,   antiPs↑, 2,   antiPy↑, 1,   AntiTum↑, 3,   cardioP?, 2,   cardioP↑, 30,   cardioP⇅, 1,   chemoP↑, 11,   chemoPv↑, 1,   cognitive↑, 9,   diuretic↑, 3,   GFR↓, 1,   GFR↑, 1,   GFR∅, 1,   hepatoP↑, 48,   memory?, 1,   memory↑, 7,   motorD↑, 1,   Mucositis↓, 1,   neuroP?, 1,   neuroP↑, 33,   Obesity↓, 8,   OS↑, 2,   Pain↓, 2,   QoL↑, 2,   radioP↑, 5,   RenoP↓, 2,   RenoP↑, 96,   RenoP↝, 2,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 6,   toxicity↓, 14,   toxicity↝, 2,   toxicity∅, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↑, 4,   AntiP↑, 1,   AntiViral↑, 4,   Bacteria↓, 11,   GutMicro↑, 7,   Sepsis↓, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 361

Scientific Paper Hit Count for: RenoP, K,Renoprotection/Nephroprotective
14 Thymoquinone
12 Cisplatin
5 Baicalein
5 Hydrogen Gas
5 Lycopene
4 Berberine
4 Chrysin
3 Silver-NanoParticles
3 Ashwagandha(Withaferin A)
3 Melatonin
3 Boron
3 Capsaicin
3 Licochalcone A
3 Morin
3 Selenium NanoParticles
3 Shikonin
2 Allicin (mainly Garlic)
2 Alpha-Lipoic-Acid
2 Curcumin
2 EGCG (Epigallocatechin Gallate)
2 Betulinic acid
2 Carvacrol
2 Chlorogenic acid
2 Dandelion Root
2 Ferulic acid
2 Fisetin
2 Grapeseed extract
2 Hibiscus sabdariffa
2 Hyperoside
2 Isoliquiritigenin
2 Isovitexin
2 Linalool
2 Luteolin
2 Chemotherapy
2 Moringa oleifera
2 5-fluorouracil
2 Marjoram (Origanum majorana)
2 Resveratrol
2 Rutin
2 Silymarin (Milk Thistle) silibinin
1 Annona atemoya Seed Extract
1 Astragalus
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Apigenin (mainly Parsley)
1 doxorubicin
1 Ascorbyl Palmitate
1 Huperzine A/Huperzia serrata
1 α-Bisabolol / Chamomile oil
1 Black Seed Oil/Nigella sativa
1 Lecithin
1 Coenzyme Q10
1 Selenium
1 Crocetin
1 Cucurbitacin
1 D-limonene
1 Echinacea
1 Emodin
1 Fucoidan
1 Ginkgo biloba
1 Germanium inorganic
1 Honokiol
1 phytic acid, Inositol hexakisphosphate
1 isoorientin
1 Kaempferol
1 Licorice
1 Lactoferrin/Talactoferrin
1 Lemongrass Extract/Citral
1 Magnesium
1 Bicarbonate(Sodium)
1 Propolis -bee glue
1 Quercetin
1 Rosmarinic acid
1 buckwheat sprouts
1 Gold NanoParticles
1 Date Fruit Extract
1 Sulforaphane (mainly Broccoli)
1 Selenite (Sodium)
1 Matrine
1 Radiotherapy/Radiation
1 methotrexate
1 Thymol-Thymus vulgaris
1 Urolithin
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1175  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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