tau Cancer Research Results

tau, tau: Click to Expand ⟱
Source:
Type:
In healthy neurons, tau binds to and stabilizes microtubules, which are essential for maintaining cell structure and facilitating axonal transport.

In AD, tau becomes abnormally hyperphosphorylated. This excessive phosphorylation reduces its affinity for microtubules, leading to destabilization of the cytoskeletal structure.
-Abnormal phosphorylated tau (p-tau) can be detected in cerebrospinal fluid (CSF) and blood plasma.
-Imaging techniques like tau PET scans can visualize tau deposits in the brain.
Natural Products targeting tau
-Curcumin                via GSK-3β inhibition
-Resveratrol             Activates SIRT1
-EGCG                    inhibits Tau, but BBB penetration is questionable
Scientific Papers found: Click to Expand⟱
8734- M-Blu,    From Mitochondrial Function to Neuroprotection – An Emerging Role for Methylene Blue
- Review, AD, NA
*ETC↑, *compIV↑, *ROS↓, *NeuroI↓, *neuroP↑, *Stroke↓, *cognitive↑, *BBB↑, *BloodF↑, *NOS2↓, *lipid-P↓, *Inflam↓, *Synergy↑, *OCR↑, *compIV↑, *ATP↑, *Casp↓, *MMP↑, *tau↓,
8728- M-Blu,    Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue
- Review, AD, NA
*Dose↝, *antiOx↑, *mitResp↑, *neuroP↑, *memory↑, *CellMemb↑, *BBB↑, *other↝, *compV↑, *OCR↑, *ROS↓, *Sepsis↓, *NO↓, *RNS↓, *memory↑, *tau↓, *CX43/GJA1↑, *THBD↑, *CARTPT↑,
8731- M-Blu,    Exploring Methylene Blue and Its Derivatives in Alzheimer's Treatment: A Comprehensive Review of Randomized Control Trials
- Review, AD, NA
*BBB↑, *cognitive↑, *Aβ↓, *memory↑, *antiOx↑, *ROS↓, *Inflam↓, *BrainVol↑, *p‑tau↓, *cellSen↝, *memory↑, *neuroP↑,
2544- M-Blu,    Methylene blue and its importance in medicine
- Review, Nor, NA
*ROS↓, *antiOx↑, *BBB↑, *neuroP↑, *GSR↓, *tau↓,
8493- MAG,    Magnolol upregulates CHRM1 to attenuate Amyloid-β-triggered neuronal injury through regulating the cAMP/PKA/CREB pathway
- in-vitro, AD, SH-SY5Y
*neuroP↑, *Aβ↓, *p‑tau↓, *Apoptosis↓, *CHRM1↑, *cAMP↑, *PKA↑, *CREB↑,
8507- MAG,    Magnolol acts as a neurorestorative agent in an Aβ1‑42‑induced mouse model of Alzheimer's disease
- in-vivo, AD, NA
*Dose?, *cognitive↑, *Aβ↓, *NeuroI↓, *neuroP↑, *tau↓, *GFAP↓, *AIF1/Iba-1↓, *GSK‐3β↑, *SYP↑, *BDNF↑,
8928- MBS,  VT,  IVT,    Neuroprotective activity of mung bean (Vigna radiata) coat extract via AMPK-dependent autophagy in Alzheimer's and Parkinson's models
- in-vitro, AD, NA - in-vitro, Park, NA
*Aβ42↓, *tau↓, *ROS↓, *motorD↑, *Ingr↝, *neuroP↑,
8931- MBS,  VT,  IVT,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer’s Disease
- Review, AD, NA
*Ingr↝, *neuroP↑, *p‑tau↓, *ROS↓, *NeuroI↓, *AChE↓,
7824- MBS,  IVT,  VT,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA - Review, Stroke, NA - Review, Park, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *ROS↓, *Inflam↓, *AChE↓, *BBB↑, *memory↑, *hepatoP↑, *Imm↑, *hyperG↓, *AntiCan↑, *eff↑, *Stroke↓, *BACE/β-secretase↓, *PI3K↓, *Akt↓, *mTOR↓, *Dose↓,
3728- MF,    Long-term exposure to ELF-MF ameliorates cognitive deficits and attenuates tau hyperphosphorylation in 3xTg AD mice
- in-vivo, AD, NA
*cognitive↑, *neuroP↑, *Apoptosis↓, *ROS↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓,
4096- MF,    Extremely Low‐Frequency and Low‐Intensity Electromagnetic Field Technology (ELF‐EMF) Sculpts Microtubules
- in-vitro, AD, NA
*p‑tau↓, *neuroP↑, *Dose↝,
8471- Mg,    Magnesium protects cognitive functions and synaptic plasticity in streptozotocin-induced sporadic Alzheimer's model
- in-vivo, AD, NA
*Learn?, *memory?, *p‑tau↓, *GSK‐3β↑, *Akt↑, *PI3K↑, *cognitive↑,
9077- MGF,    Long-Term Mangiferin Extract Treatment Improves Central Pathology and Cognitive Deficits in APP/PS1 Mice
- in-vivo, AD, NA
*Dose↝, *p‑tau↓, *Inflam↓, *memory↑,
9078- MGF,    Mangiferin Alleviates Formaldehyde-Induced Tau Hyperphosphorylation and Cognitive Impairment in Mice via the PI3K/AKT/GSK3β Pathway: Insights From Network Pharmacology and Experimental Validation
- in-vivo, AD, NA
*memory↑, *cognitive↑, *Apoptosis↓, *p‑tau↓, *PI3K↑, *Akt↑, *GSK‐3β↓,
9085- MGF,    The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment
- vitro+vivo, AD, HT22
*p‑tau↓, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *GSK‐3β↓, *CaMKII ↓, *Ca+2↓, *ROS↓, *mtDam↓, *Dose↝, *Learn↑, *memory↑, *neuroP↑, *cognitive↑,
8657- MLT,    Melatonin in Alzheimer's Disease: Literature Review and Therapeutic Trials
- Review, AD, NA
*toxicity↓, *Sleep↑, *antiOx↑, *AntiMyl↑, *p‑tau↓, *Aβ↓, *TC↓, *neuroP↑, *ROS↓, *BBB↑, *Learn↑, *memory↑, *Synergy↑, *Dose↝,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
3834- MO,    Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer's Disease-Like Pathology and Cognitive Impairments
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *Aβ↓, *BACE/β-secretase↓, *cal2↓, *p‑tau↓, *ROS↓, *SOD↑, *MDA↓, *cognitive↑, *memory↑,
8915- MO,    Therapeutic Potential of Moringa oleifera in Alzheimer’s Disease: A Review of Neuroprotective Mechanisms
- Review, AD, NA
*Ingr↝, *antiOx↑, *Inflam↓, *NRF2↑, *ARE↑, *AChE↓, *Aβ42↓, *cognitive↑, *BACE/β-secretase↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *Learn↑, *memory↑, *ATP↑, *SOD↑, *Catalase↑, *p‑tau↓,
8916- MO,  AgNPs,  M-Blu,    Synergistic Neuroprotection in Tauopathic Mice via Green-Synthesized Silver Nanoparticles Co-delivering Methylene Blue and Moringa oleifera
- in-vivo, AD, NA
*Dose↝, *GSK‐3β↓, *motorD↑, *cognitive↑, *TNF-α↓, *IL6↓, *LC3B↑, *SOD↑, *neuroP↑, *p‑tau↓, *p‑Akt↑,
8873- MOR,  Zeo,    Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlCl3-Induced Alzheimer's Disease in Rats: Neuroprotective Effect of Morin Hydrate, Zeolite Clinoptilolite, and Physical Plus Mental Activities
- in-vivo, AD, NA
*neuroP↑, *p‑tau↓, *antiOx↑, *Ferroptosis↓, *NRF2↑, *Learn↑, *memory↑, *AChE↓, *HO-1?, *SOD↑, *TAC↑, *GPx4↑, *Synergy↑, *TLR4↓, *BAX↓, *Bcl-2↑, *BDNF↑, *Wnt↑, *β-catenin/ZEB1↑, *APP↓, *BACE/β-secretase↓,
8870- MOR,    Morin reverses neuropathological and cognitive impairments in APPswe/PS1dE9 mice by targeting multiple pathogenic mechanisms
- in-vivo, AD, NA
*neuroP↑, *Learn↑, *memory↑, *Aβ↓, *APP↝, *ADAM10↑, *BACE/β-secretase↓, *PSEN1/PS1↓, *p‑tau↓, *CDK5↓, *cognitive↑,
8869- MOR,    Morin attenuates tau hyperphosphorylation by inhibiting GSK3β
- vitro+vivo, AD, NA
*GSK‐3β↓, *p‑tau↓, *neuroP↑, *Aβ↓,
3848- MSM,    Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
- in-vitro, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *ER(estro)↑, *NRF2↑, *HO-1↑, *Trx1↑, *TXNIP↓, *MDA↓, *NOX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *BDNF↑, *AChE↓, *p‑tau↓, *Aβ↓,
8959- mushLions,  BM,  L-THE,    Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
- Review, AD, NA
*Synergy↑, *neuroP↑, *INF-γ↑, *BDNF↑, *Synergy↑, *Synergy↑, *BBB↑, *Ki-67↑, *p‑CREB↑, *tau↓, *GSK‐3β↓, *Wnt↑, *β-catenin/ZEB1↑, *memory↑, *Sleep↑, *p‑NF-kB↓, *ROS↓, *Stress↓,
3812- mushLions,    Structural characterization of polysaccharide purified from Hericium erinaceus fermented mycelium and its pharmacological basis for application in Alzheimer's disease: Oxidative stress related calcium homeostasis
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *p‑tau↓, *ROS↓, *NRF2↓, *Ca+2↝,
3810- mushLions,    Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *p‑tau↓, *APP↓, *Aβ↓, *ROS↓, *Inflam↓, *NLRP3↓,
4036- NAD,  VitB3,    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
- in-vivo, AD, NA
*Inflam↓, *p‑tau↓, *DNAdam↓, *memory↑, *motorD↑, *cognitive↑, *BBB↑, IL1β↓, *TNF-α↓, *MCP1/CCL2↓, *RANTES↓, *ROS↓, *SIRT3↑, *SIRT6↑,
2033- PB,    Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model
- in-vivo, AD, NA
*p‑tau↓, *GSK‐3β↓, *ac‑Histones↑, *neuroP↑,
7831- PCA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *neuroP↑, *Aβ↓, *p‑tau↓, *autophagy↓, *GSK‐3β↓, *NeuroI↓, *iNOS↓, *COX2/PTGS2↓, *BDNF↑, *MEF2D↑, *cognitive↑, *memory↑,
3598- PI,    Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer's disease
- in-vivo, AD, NA
*ROS↓, *Inflam↓, *cognitive↑, *Aβ↓, *tau↓,
3919- PTS,    Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *SIRT1∅, *PPARα↑, *SOD2↑, *JNK↓, *p‑tau↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *lipid-P↓, *antiOx↑, *Aβ↓, *Inflam↓, *BBB↝, *NF-kB↓, *iNOS↓, *memory↑, *cognitive↑, *AChE↓, *MMP↑, *ROS↓, *ATP↑, *AMPK↑, *NADPH↓, *p‑tau↓,
7826- QC,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA - Review, Stroke, NA - Review, Park, NA
*Stroke↓, *Inflam↓, *AGEs↓, *cognitive↑, *memory↑, *Dose↝, *neuroP↑, *p‑tau↓, *GSK‐3β↓, *CDK5↓,
4297- QC,    Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway
- in-vitro, AD, SH-SY5Y
*AMPK↑, *IRE1↓, *p‑PERK↓, *p‑tau↓, *cognitive↑, *antiOx↑, *ER Stress↓, *Inflam↓, *neuroP↑, *TXNIP↓, *NLRP3↓,
6051- RES,  SeNPs,  Chit,    Resveratrol-loaded selenium/chitosan nano-flowers alleviate glucolipid metabolism disorder-associated cognitive impairment in Alzheimer's disease
- in-vivo, AD, NA
*Inflam↓, *ROS↓, *GutMicro↑, *lipid-P↓, *Aβ↓, *tau↓, *cognitive↑,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2/PTGS2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE/β-secretase↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,
4285- RES,    Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy
- in-vivo, AD, NA
*tau↓, *cognitive↑, *Inflam↓,
4289- RES,    Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells
- in-vitro, AD, NA
*antiOx↑, *p‑tau↓, *GSK‐3β↓, *CaMKII ↓, *PP2A↑, *neuroP↑,
4288- RES,    Trans-resveratrol Inhibits Tau Phosphorylation in the Brains of Control and Cadmium Chloride-Treated Rats by Activating PP2A and PI3K/Akt Induced-Inhibition of GSK3β
- in-vivo, AD, NA
*memory↑, *GSH↑, *ROS↓, *MDA↓, *p‑tau↓, *PI3K↑, *Akt↑, *AMPK↑, *PP2A↑, *GSK‐3β↓,
4287- RES,    Resveratrol targeting tau proteins, amyloid-beta aggregations, and their adverse effects: An updated review
- Review, AD, NA
*p‑tau↓,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE/β-secretase↓,
3011- RosA,    Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition
- in-vitro, GBM, SH-SY5Y - in-vitro, Lung, A549 - in-vitro, Nor, HEK293 - in-vitro, Nor, MCF10
MARK4↓, p‑tau↓, selectivity↑, *toxicity∅,
3937- RT,    Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease
- in-vivo, AD, NA
*p‑tau↓, *Inflam↓, *NF-kB↓, *cognitive↑, *Aβ↓, *memory↑, *neuroP↑, *BioAv↓, *BBB↑,
4114- SAMe,    S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research
- Review, AD, NA
*Mood↑, *BBB↑, *5HT↑, *p‑tau↓, *Aβ↓, *other↑,
6060- SeNPs,    Multifunctional Selenium Quantum Dots for the Treatment of Alzheimer's Disease by Reducing Aβ-Neurotoxicity and Oxidative Stress and Alleviate Neuroinflammation
- Study, AD, NA
*BBB↑, *ROS↓, *Aβ↓, *p‑tau↓, *neuroP↑,
6058- SeNPs,  RES,  QC,  CAR,    Engineered nanoplatforms for brain-targeted co-delivery of phytochemicals in Alzheimer's disease: Rational design, blood-brain barrier penetration, and multi-target therapeutic synergy
- Review, AD, NA
*DDS↑, *cognitive↑, *Aβ↓, *tau↓, *Inflam↓, *antiOx↑, *CompStab↑, *CompStab↑, *neuroP↑, *BioAv↑, *AChE↓,
6048- SeNPs,    Unravelling the in vitro and in vivo potential of selenium nanoparticles in Alzheimer's disease: A bioanalytical review
- Review, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *Aβ↓, *tau↓, *neuroP↑, *cognitive↑,
3664- SFN,    Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*CHIP↑, *HSP70/HSPA5↑, *Aβ↓, *tau↓,

Showing Research Papers: 101 to 150 of 177
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 177

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Iron↝, 1,   NOX↓, 1,   NOX4↓, 1,   NRF2↓, 1,   ROS↓, 3,   ROS↑, 6,   SOD↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MFN2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,   GSK‐3β↑, 1,   SIRT1↓, 1,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 5,   BAX↓, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 3,   cl‑Casp3⇅, 1,   Casp9↑, 4,   Cyt‑c↑, 3,   Ferroptosis↑, 1,   Mcl-1↓, 1,   MDM2↓, 1,   Necroptosis↑, 1,   p38↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   EGFR↓, 2,   ERK↓, 2,   HER2/EBBR2↓, 1,   MAPK↓, 1,   MAPK↝, 1,   MARK4↓, 1,   mTOR↝, 1,   PI3K↓, 1,   PKCδ↓, 2,   RAS↓, 1,   STAT3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   HDAC2↓, 1,   miR-25-5p↓, 1,   other↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↓, 1,   P53↑, 1,   PARP↑, 2,   cl‑PARP↑, 2,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   mitA↑, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Shh↓, 1,   TumCP↓, 4,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   BACH1↓, 1,   Ca+2↑, 1,   EMT↓, 2,   KRAS↓, 1,   LAMs↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Smad1↓, 1,   TGF-β↓, 2,   TumCI↓, 2,   TumCMig↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   Hif1a↓, 2,   VEGF↓, 5,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   MMP↓, 2,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   COX2/PTGS2↑, 1,   IFN-γ↑, 1,   IL12↑, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 1,   NF-kB↓, 3,   PD-1↓, 1,   PGE2↓, 1,   TNF-α↓, 3,  

Protein Aggregation(tgid=19) ⓘ

p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ERα/ESR1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 5,   Dose↝, 1,   eff↑, 2,   Half-Life↓, 1,   P-gp/ABCB1↓, 2,   selectivity↑, 3,   Synergy↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 2,   ERα/ESR1↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 1,   KRAS↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   cardioP↑, 2,   hepatoP↑, 1,   memory↑, 1,   NP/CIPN↓, 1,   Obesity↓, 1,  
Total Targets: 119

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 4,   antiOx↑, 57,   ARE↑, 1,   Catalase↓, 1,   Catalase↑, 17,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 15,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 25,   GSR↓, 1,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 3,   H2O2↓, 1,   HDL↑, 1,   HNE↓, 1,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 19,   HO-2↓, 1,   hyperG↓, 1,   Iron↝, 1,   Keap1↝, 1,   lipid-P↓, 24,   MDA↓, 19,   MDA↑, 2,   MPO↓, 3,   NOX↓, 1,   NQO1↑, 5,   Nrf1↑, 2,   NRF2↓, 2,   NRF2↑, 31,   RNS↓, 2,   ROS?, 1,   ROS↓, 93,   mt-ROS?, 1,   mt-ROS↓, 1,   SOD↓, 1,   SOD↑, 30,   mt-SOD↑, 1,   SOD2↑, 1,   TAC↑, 7,   TBARS↓, 2,   Thiols↑, 1,   Trx1↑, 1,   TrxR↑, 1,   VitC↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   IronCh↑, 3,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIV↑, 2,   compV↑, 1,   ETC↑, 1,   FIS1↓, 1,   Insulin↑, 1,   mitResp↑, 1,   mtDam↓, 3,   OCR↑, 2,   PDH↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 4,   PGC-1α↝, 1,   SIRT3↑, 3,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↓, 1,   Acetyl-CoA↓, 1,   Acetyl-CoA↑, 1,   ALAT↓, 2,   AMPK↑, 10,   ATP↑, 10,   cAMP↑, 2,   FAO↑, 1,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↑, 3,   Glycolysis↑, 1,   GSK‐3β↓, 33,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 2,   ac‑Histones↑, 1,   HK1↑, 1,   LDL↓, 7,   NAD↑, 1,   NADPH↓, 2,   NADPH↑, 1,   PDKs↓, 1,   SIRT1↓, 1,   SIRT1↑, 6,   SIRT1∅, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 12,   BAX↓, 5,   BAX↑, 2,   Bax:Bcl2↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 7,   Casp↓, 1,   Casp1↓, 1,   Casp3↓, 9,   Casp3↑, 1,   cl‑Casp3↓, 1,   Casp9↑, 1,   Ferroptosis↓, 3,   iNOS↓, 10,   necrosis↓, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 15,   p‑Akt↓, 2,   p‑Akt↑, 3,   CaMKII ↓, 2,   CREB↓, 1,   CREB↑, 5,   p‑CREB↑, 4,   DYRK1A↓, 2,   ERK↓, 2,   ERK↑, 2,   p‑ERK↓, 1,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 6,   MAPK↑, 1,   mTOR↓, 6,   mTOR↑, 2,   p‑mTOR↓, 1,   PI3K↓, 4,   PI3K↑, 12,   PKA↑, 3,   PKCδ↑, 2,   PP2A↑, 8,   PTEN↓, 2,   PTP1B↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   DNMT1↓, 1,   HDAC?, 1,   HDAC↓, 1,   HDAC2↓, 1,   MEF2D↑, 1,   other↓, 1,   other↑, 6,   other↝, 12,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   ER Stress↓, 3,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 3,   HSP90↓, 1,   HSPs↝, 1,   IRE1↓, 1,   p‑PERK↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   autophagy↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   CTSZ↓, 1,   CTSZ↝, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 2,   lysosome↑, 1,   MitoP↑, 3,   p62↓, 1,   p62↑, 2,   PARK2↑, 1,   TFEB↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   P53↓, 2,   PARP1↓, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 6,   cellSen↝, 1,   Ki-67↓, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CHIP↑, 2,   Ki-67↓, 1,   Ki-67↑, 1,   mTORC1↓, 1,   neuroG↑, 3,   Wnt↑, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 10,   Ca+2↝, 1,   cal2↓, 1,   Cartilage↑, 1,   LRP1↑, 1,   MMP-10↝, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 1,   N-cadherin↑, 1,   ROCK1↓, 1,   TXNIP↓, 3,   β-catenin/ZEB1↑, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   CD31/PECAM-1↑, 1,   Hif1a↓, 1,   Hif1a↑, 2,   NO↓, 7,   NO↑, 1,   VCAM-1↓, 2,   VEGF↑, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 30,   BBB↝, 1,   BBB∅, 1,   CellMemb↑, 1,   CX43/GJA1↑, 1,   GLUT3↑, 2,   GLUT4↑, 2,   MMP↑, 8,   THBD↑, 1,   TRPA1↑, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 11,   COX2/PTGS2↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 2,   IL10↑, 3,   IL12↓, 2,   IL17↓, 2,   IL18↓, 1,   IL1α↓, 1,   IL1β↓, 22,   IL1β↑, 1,   IL2↓, 2,   IL22↓, 1,   IL23↓, 1,   IL33↓, 1,   IL4↓, 1,   IL4↑, 3,   IL6↓, 26,   IL8↓, 2,   Imm↑, 1,   INF-γ↑, 1,   Inflam?, 1,   Inflam↓, 84,   Inflam↑, 1,   IRF3↓, 1,   LPS↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 6,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 9,   NF-kB↓, 29,   p‑NF-kB↓, 3,   NLRP3↓, 10,   p‑p65↓, 1,   PGE2↓, 1,   RANTES↓, 1,   TLR2↓, 1,   TLR3↓, 1,   TLR4↓, 4,   TNF-α↓, 37,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 5,   Ach↑, 13,   AChE↓, 37,   ADAM10↑, 4,   BChE↓, 7,   BDNF↓, 1,   BDNF↑, 20,   BrainVol↑, 1,   CARTPT↑, 1,   ChAT↑, 6,   CHRM1↑, 1,   GABA↑, 1,   MAOA↓, 3,   MAOB↓, 4,   NGF↑, 2,   PSD95↑, 2,   RELN↑, 1,   SNAP25↑, 1,   SYP↑, 1,   TrkB↓, 1,   TrkB↑, 2,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 15,   APP↝, 1,   Aβ↓, 100,   Aβ42↓, 5,   BACE/β-secretase↓, 31,   IDE↑, 1,   PSEN1/PS1↓, 2,   tau?, 1,   tau↓, 69,   p‑tau↓, 106,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AKR1C3/17β-HSD5/PGF Synthase↑, 1,   ER(estro)↑, 1,   PPARα↑, 4,   PPARγ↓, 2,   PPARγ↑, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 14,   BioAv↑, 24,   BioAv↝, 6,   ChemoSen↑, 1,   CompStab↑, 2,   DDS↑, 1,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose↝, 25,   eff↓, 1,   eff↑, 11,   Half-Life↑, 1,   Half-Life↝, 1,   P450↑, 1,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALB↑, 1,   anemia↓, 1,   AST↓, 2,   BloodF↑, 2,   BP↓, 1,   CRP↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   Hcy/homoC↓, 1,   HemoG↑, 2,   IL6↓, 26,   IRes↓, 1,   NOS2↓, 1,   RBC↑, 1,   TC↓, 2,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 3,   AntiCan↑, 7,   AntiDiabetic↑, 4,   AntiMyl↑, 1,   antiPs↑, 1,   ANXi↓, 1,   cardioP↑, 10,   chemoP↑, 1,   cognitive↑, 93,   cognitive↝, 1,   diuretic↑, 1,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 7,   Learn?, 1,   Learn↑, 7,   memory?, 1,   memory↑, 83,   Mood↑, 3,   motorD↓, 1,   motorD↑, 7,   neuroP↑, 110,   Obesity↓, 4,   OS↑, 4,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 7,   Sleep↑, 4,   Strength↑, 5,   Stress↓, 1,   Stroke↓, 5,   toxicity↓, 9,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 3,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiViral↑, 4,   Bacteria↓, 4,   GutMicro↑, 13,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 390

Scientific Paper Hit Count for: tau, tau
9 Curcumin
9 Resveratrol
9 Urolithin
7 Mung Bean Sprouts
7 EGCG (Epigallocatechin Gallate)
6 Cinnamon
6 Emodin
5 Berberine
5 Selenium NanoParticles
5 Shilajit/Fulvic Acid
5 Ginseng
5 Luteolin
5 Methylene blue
5 Quercetin
4 Caffeic acid
4 Capsaicin
4 Hydrogen Gas
4 isoorientin
4 Vitamin B1/Thiamine
3 Bacopa monnieri
3 Folic Acid, Vit B9
3 Ferulic acid
3 Rosmarinic acid
3 Sulforaphane (mainly Broccoli)
3 Vitexin
3 Isovitexin
3 Mangiferin
3 Moringa oleifera
3 Morin
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Thymoquinone
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Chlorogenic acid
2 Crocetin
2 Lactoferrin/Talactoferrin
2 Lycopene
2 Magnolol
2 Magnetic Fields
2 Melatonin
2 Vitamin B3,Niacin
2 Vitamin K2
1 1,8-Cineole
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Aromatherapy
1 Beta-Caryophyllene
1 xanthohumol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Calorie Restriction Mimetics
1 Phosphatidylserine
1 Fisetin
1 Flickering Light Stimulation
1 Formononetin
1 Ginkgo biloba
1 hydrogen sulfide
1 Hydroxycinnamic-acid
1 Honokiol
1 Hyperoside
1 Isobavachalcone
1 isoquercitrin
1 Isothiocyanates
1 Potassium
1 Kaempferol
1 Licochalcone A
1 Vitamin E
1 Magnesium
1 Silver-NanoParticles
1 Zeolite
1 Methylsulfonylmethane
1 L-Theanine
1 nicotinamide adenine dinucleotide
1 Phenylbutyrate
1 Protocatechuic acid
1 Piperine
1 Pterostilbene
1 chitosan
1 Rutin
1 S-adenosyl-L-methionine
1 Carvacrol
1 Shankhpushpi
1 Silymarin (Milk Thistle) silibinin
1 Ursolic acid
1 Vitamin A, Retinoic Acid
1 Vitamin B12
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 probiotics
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1231  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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