| Source: |
| Type: |
| AChE is an enzyme that rapidly hydrolyzes the neurotransmitter acetylcholine into choline and acetate, terminating cholinergic signals. - In some cancers, studies have reported reduced AChE activity, which may contribute to an accumulation of acetylcholine. - Lower levels or loss of AChE expression/activity have been associated with more aggressive tumor behavior and poor prognosis, possibly due to unchecked cholinergic signaling. For AD (Alzheimer's), AChE inhibitors are used, to allow ACh, and ChAT to increase along with acetyl-CoA -Natural AChE inhibitors: Ferulic Acid, Caffeic Acid, Rosmarinic Acid, Sage -AChE inhibitors only temporarily relieve some of the disease’s cognitive symptoms and do not stop the patient’s cognitive loss -adverse effects such as disorientation, falls, dizziness, and fatigue may occur with these medications and should be used only as recommended - Natural AChE inhibitors paper |
| 6923- | Flav, | Flavonoids: an overview |
| - | Review, | Nor, | NA |
| 6981- | Form, | Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | PSA, | NA |
| 7049- | GA, | Pharmacological effects of gallic acid in health and diseases: A mechanistic review |
| - | Review, | Var, | NA |
| 7082- | GABA, | Contributions of Gamma-Aminobutyric Acid (GABA) Produced by Lactic Acid Bacteria on Food Quality and Human Health: Current Applications and Future Prospects |
| - | Review, | AD, | NA |
| 7090- | GAR, | Garcinol |
| - | in-vitro, | Var, | NA |
| 7093- | GAR, | Garcinol |
| - | Review, | AD, | NA |
| 8582- | GBE, | Cro, | Sage, | MO, | A comprehensive systematic review of human trials investigating herbal treatments for Alzheimer’s disease and dementia |
| - | Review, | AD, | NA |
| 3723- | GBE, | Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies |
| - | Review, | AD, | NA |
| 6562- | Ger, | Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 6573- | Ger, | Systematic elucidation of the mechanism of geraniol via network pharmacology |
| - | Study, | Nor, | NA | - | Study, | Var, | NA |
| - | Study, | AD, | NA |
| 2869- | HNK, | Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 4210- | Hup, | A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies–Emphasis on Alzheimer’s Disease Pathogenesis |
| - | Review, | AD, | NA |
| 7479- | Hup, | A phase II trial of huperzine A in mild to moderate Alzheimer disease |
| - | Trial, | AD, | NA |
| 3804- | Hup, | Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials |
| - | Review, | AD, | NA |
| 3803- | Hup, | Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease |
| - | Review, | AD, | NA |
| 3802- | Hup, | New insights into huperzine A for the treatment of Alzheimer's disease |
| - | Review, | AD, | NA |
| 3801- | Hup, | An update on huperzine A as a treatment for Alzheimer's disease |
| - | Review, | AD, | NA |
| 3800- | Hup, | Role of huperzine a in the treatment of Alzheimer's disease |
| - | Review, | AD, | NA |
| 3799- | Hup, | The use of Huperzia species for the treatment of Alzheimer's disease |
| - | Review, | AD, | NA |
| 3805- | Hup, | Isolation, diversity and acetylcholinesterase inhibitory activity of the culturable endophytic fungi harboured in Huperzia serrata from Jinggang Mountain, China |
| - | Analysis, | AD, | NA |
| 7565- | HYP, | Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review |
| - | Review, | AD, | NA |
| 7564- | HYP, | Pharmacological activities and therapeutic potential of Hyperoside in the treatment of Alzheimer's and Parkinson's diseases: A systemic review |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 7879- | isoO, | Isoorientin improves scopolamine-induced cognitive impairments by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling in the hippocampus and frontal cortex |
| - | in-vivo, | AD, | NA |
| 7836- | ISQ, | An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease |
| - | in-vivo, | AD, | NA |
| 7917- | IVT, | A review on the pharmacological effects of vitexin and isovitexin |
| - | Review, | Nor, | NA | - | Review, | AD, | NA |
| 7891- | IVT, | VT, | Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin |
| - | Review, | AD, | NA |
| 7827- | KAE, | MBS, | Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review |
| - | Review, | AD, | NA |
| 8053- | KAE, | Kaempferol as a therapeutic agent in Alzheimer's disease: Evidence from preclinical studies |
| - | Review, | AD, | NA |
| 8234- | LCA, | Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment |
| - | Review, | AD, | NA |
| 8227- | LCA, | Licochalcone A as Novel Multitarget Inhibitors via AChE, BuChE, and Synapsin III for Therapeutic Intervention Against Alzheimer’s Disease: Computer-Aided Drug Design |
| - | Study, | AD, | NA |
| 8140- | LF, | Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival |
| - | in-vitro, | NSCLC, | A549 | - | in-vitro, | NSCLC, | H1299 |
| 7825- | LT, | MBS, | Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review |
| - | Review, | AD, | NA |
| 8382- | LT, | Luteolin as a dietary flavonoid for brain health: modulating neuroinflammation and cognitive decline in neurodegenerative disorders |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 8398- | LT, | Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 2916- | LT, | Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 8421- | Lyco, | Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease |
| - | Review, | AD, | NA |
| 8416- | Lyco, | Lycopene alleviates cognitive dysfunctions in an Alzheimer's disease rat model via suppressing the oxidative and neuroinflammatory signaling |
| - | in-vivo, | AD, | NA |
| 8522- | MAG, | Effects of magnolol on impairment of learning and memory abilities induced by scopolamine in mice |
| - | in-vivo, | AD, | NA |
| 8502- | MAG, | Magnolol as a promising multitarget agent for Alzheimer's disease: Evidence from a systematic evidence synthesis, network pharmacology, and molecular dynamics simulations |
| - | Review, | AD, | NA |
| 5252- | MAG, | Insights on the Multifunctional Activities of Magnolol |
| - | Review, | Var, | NA |
| 8553- | Matr, | Research progress on the pharmacological effects of matrine |
| - | Review, | Nor, | NA |
| 8552- | Matr, | Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways |
| - | Review, | AD, | NA |
| 7824- | MBS, | IVT, | VT, | Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review |
| - | Review, | AD, | NA | - | Review, | Stroke, | NA | - | Review, | Park, | NA |
| 8931- | MBS, | VT, | IVT, | Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer’s Disease |
| - | Review, | AD, | NA |
| - | in-vitro, | AD, | NA |
| 3745- | MFrot, | MF, | The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease |
| - | Review, | AD, | NA |
| 8689- | MLT, | Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies |
| - | Review, | AD, | NA |
| 6042- | MO, | CGA, | Characterization of the Anticholinesterase and Antioxidant Properties of Phytochemicals from Moringa oleifera as a Potential Treatment for Alzheimer’s Disease |
| - | Analysis, | AD, | NA |
| 4226- | MO, | The Oil Formulation Derived from Moringa Oleifera Seeds Ameliorates Behavioral Abnormalities in Water-immersion Restraint Stress Mouse Model |
| - | in-vivo, | AD, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:1329 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid