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| Brain-Derived Neurotrophic Factor (BDNF) is a key neurotrophin (a type of growth factor) involved in brain health, and its role in Alzheimer’s Disease (AD) has been extensively studied. -AD patients often have lower BDNF levels in key brain regions, such as the hippocampus and cortex. -This reduction correlates with cognitive decline and brain atrophy. -BDNF normally protects neurons from Aβ toxicity -Exercise and cognitive training have been shown to boost BDNF levels and may slow cognitive decline. - natural compounds (like curcumin or flavonoids) may also upregulate BDNF. |
| 4232- | Lut, | Luteolin Treatment Ameliorates Brain Development and Behavioral Performance in a Mouse Model of CDKL5 Deficiency Disorder |
| - | in-vivo, | NA, | NA |
| 4231- | Lut, | Luteolin and its antidepressant properties: From mechanism of action to potential therapeutic application |
| - | Review, | AD, | NA |
| 4192- | Lut, | Zeax, | Lutein and Zeaxanthin Supplementation Improves Dynamic Visual and Cognitive Performance in Children: A Randomized, Double-Blind, Parallel, Placebo-Controlled Study |
| - | Trial, | NA, | NA |
| 4230- | Lyco, | Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway |
| - | in-vivo, | AD, | NA |
| 4227- | Lyco, | Lycopene Alleviates Depression-Like Behavior in Chronic Social Defeat Stress-Induced Mice by Promoting Synaptic Plasticity via the BDNF-TrkB Pathway |
| - | in-vivo, | NA, | NA |
| 4229- | Lyco, | Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in β-amyloid induced Alzheimer׳s disease |
| - | in-vivo, | AD, | NA |
| 4228- | Lyco, | A review for the pharmacological effect of lycopene in central nervous system disorders |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 4780- | Lyco, | Potential inhibitory effect of lycopene on prostate cancer |
| - | Review, | Pca, | NA |
| 4784- | Lyco, | Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives |
| - | Review, | Diabetic, | NA | - | Review, | CardioV, | NA |
| 5252- | MAG, | Insights on the Multifunctional Activities of Magnolol |
| - | Review, | Var, | NA |
| 4148- | MF, | Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke Patients |
| - | Human, | Stroke, | NA |
| 4147- | MF, | PEMFs Restore Mitochondrial and CREB/BDNF Signaling in Oxidatively Stressed PC12 Cells Targeting Neurodegeneration |
| - | in-vitro, | AD, | PC12 |
| - | in-vivo, | AD, | NA |
| 4150- | MF, | Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice |
| - | in-vitro, | NA, | NA |
| 4149- | MF, | Pulsed Electro-Magnetic Field (PEMF) Effect on Bone Healing in Animal Models: A Review of Its Efficacy Related to Different Type of Damage |
| - | Review, | NA, | NA |
| 4118- | MF, | Effects of transcranial magnetic stimulation on neurobiological changes in Alzheimer's disease |
| - | Review, | AD, | NA |
| 4119- | MF, | Therapeutic potential and mechanisms of repetitive transcranial magnetic stimulation in Alzheimer’s disease: a literature review |
| - | Review, | AD, | NA |
| 3737- | MF, | The Effect of Time-Dependence of 10 Hz Electromagnetic Field on Spatial Learning and Memory in Rats |
| - | in-vivo, | AD, | NA |
| 3745- | MFrot, | MF, | The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease |
| - | Review, | AD, | NA |
| 4169- | Mg, | Effects of Elevation of Brain Magnesium on Fear Conditioning, Fear Extinction, and Synaptic Plasticity in the Infralimbic Prefrontal Cortex and Lateral Amygdala |
| - | in-vivo, | NA, | NA |
| 4168- | Mg, | Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway |
| - | in-vivo, | NA, | NA |
| 4226- | Moringa, | The Oil Formulation Derived from Moringa Oleifera Seeds Ameliorates Behavioral Abnormalities in Water-immersion Restraint Stress Mouse Model |
| - | in-vivo, | NA, | NA |
| 3848- | MSM, | Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway |
| - | in-vitro, | AD, | NA |
| 3814- | mushLions, | Lion's Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model |
| - | in-vitro, | AD, | NA |
| 4160- | NAD, | The biochemical pathways of central nervous system neural degeneration in niacin deficiency |
| - | Review, | NA, | NA |
| 4223- | NarG, | Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia–Reperfusion Model of Rats |
| - | in-vivo, | Stroke, | NA |
| 4224- | NarG, | The Effect of Naringin on Cognitive-Behavioral Functions, CREB/BDNF Signaling, Cholinergic Activity, and Neuronal Density in the Hippocampus of an MSG-Induced Obesity Rat Model |
| - | in-vivo, | Obesity, | NA | - | NA, | AD, | NA |
| 4225- | NarG, | Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury |
| - | in-vivo, | NA, | NA |
| 4156- | PB, | The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain |
| - | in-vivo, | AD, | NA |
| 4218- | PBG, | The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells |
| - | in-vitro, | Nor, | SH-SY5Y | - | in-vitro, | AD, | NA |
| 4219- | PBG, | Propolis Increases Brain Derived Neurotrophic Factor Expression in the Prefrontal Cortex of Rat Stress Model |
| - | in-vivo, | AD, | NA |
| 4220- | PI, | Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination |
| - | in-vivo, | AD, | NA | - | in-vivo, | MS, | NA |
| 4221- | PI, | Piperine-like alkamides from Piper nigrum induce BDNF promoter and promote neurite outgrowth in Neuro-2a cells |
| - | in-vitro, | NA, | NA |
| 4222- | PI, | Potential of piperine for neuroprotection in sepsis-associated encephalopathy |
| - | in-vivo, | Sepsis, | NA |
| 4170- | ProBio, | PB, | Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine |
| - | in-vivo, | NA, | NA |
| 3922- | PTS, | Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway |
| - | in-vivo, | AD, | NA |
| 4162- | QC, | Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway |
| - | in-vivo, | Stroke, | NA |
| 4296- | QC, | A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders |
| - | Review, | AD, | NA |
| 4153- | RES, | Effect of oral resveratrol on the BDNF gene expression in the hippocampus of the rat brain |
| - | in-vivo, | AD, | NA |
| 4154- | RES, | Resveratrol improves postnatal hippocampal neurogenesis and brain derived neurotrophic factor in prenatally stressed rats |
| - | in-vivo, | AD, | NA |
| 3798- | RES, | Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure |
| - | in-vivo, | NA, | NA |
| 4286- | RES, | Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease |
| - | Review, | AD, | NA |
| 4217- | Sage, | RosA, | Aroma, | Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 4214- | Se, | Selenium ameliorates cognitive impairment through activating BDNF/TrkB pathway |
| - | in-vivo, | NA, | NA |
| 4189- | Sesame, | Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways |
| - | in-vivo, | AD, | NA |
| 4190- | Sesame, | Sesame Seeds: A Nutrient-Rich Superfood |
| - | Review, | NA, | NA |
| 4200- | SFN, | Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription |
| - | in-vitro, | NA, | NA |
| 4202- | SFN, | Regulation of BDNF transcription by Nrf2 and MeCP2 ameliorates MPTP-induced neurotoxicity |
| - | Review, | Park, | NA |
| 4201- | SFN, | Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents |
| - | in-vivo, | NA, | NA |
| 4199- | SFN, | Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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