chemoPv Cancer Research Results

chemoPv, ChemoPreventive: Click to Expand ⟱
Source:
Type:
Chemopreventive: An agent that lowers the probability of cancer development or delays progression from premalignant states.
Mechanisms
-Reduce DNA damage / mutagenesis
-Enhance detoxification or repair
-Modulate hormones or inflammation
-Promote differentiation or apoptosis of abnormal cells


Scientific Papers found: Click to Expand⟱
7552- HYP,    Hyperoside exerts potent anticancer activity in skin cancer
- vitro+vivo, Melanoma, NA
AntiCan↑, *Inflam↓, *antiOx↑, PI3K↓, Akt↓, mTOR↓, TumCP↓, Apoptosis↑, TumAuto↑, chemoPv↑,
7601- I3C,    Prevention and treatment of cancer with indole-3-carbinol
- Review, BC, NA
Estro↝, 2/16-OHE1↑, chemoPv↑,
7602- I3C,    Dose-ranging study of indole-3-carbinol for breast cancer prevention
- Trial, BC, NA
toxicity↓, Dose↝, 2/16-OHE1↑, chemoPv↑,
7595- I3C,    Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans
- Human, Nor, NA
*Dose↝, *other↓, *chemoPv↑,
7629- Ins,    Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol
- in-vivo, Lung, NA
AntiCan↑, TumVol↓, PI3K↓, IL6↓, p‑STAT3↓, chemoPv↑,
7648- Ins,    Suppression of lung and liver carcinogenesis in mice by oral administration of myo-inositol
- in-vivo, Liver, NA
AntiCan↑, Dose↝, Risk↓, chemoPv↑,
7656- IP,    Inulin Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Levels to Inhibit Colon Tumorigenesis in Rat Models: A Systematic Review and Meta-Analysis
- Review, CRC, NA
GutMicro↑, chemoPv↑, SCFAs↑,
7718- IP6,    Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes
- in-vitro, Pca, DU145
chemoPv↑, TumCG↓, TumCCA↑, P21↓, p27/CDKN1B↑, CDK2↓, CDK4↓, CDK6↓, cycE/CCNE↓, cycD1/CCND1↓, pRB↑, Apoptosis↑, cl‑PARP↑, Casp3↑,
7720- IP6,    Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention
- Review, Nor, NA
*ROS?, *IronCh↑, *chemoPv↑,
7789- ISL,    Cancer Chemopreventive Activity and Metabolism of Isoliquiritigenin, a Compound Found in Licorice
- Review, Nor, NA
*GSH↑, *GSTs↑, *chemoPv↑,
7733- isoFl,    Soy-derived isoflavones as chemo-preventive agents targeting multiple signalling pathways for cancer prevention and therapy
- Review, Var, NA
chemoPv↑, HOTAIR↓, VEGF↓, CXCL12↓, CXCR4↓, ER-α36↝, Shh↓, miR-155↝, miR-34a↝, miR-10a-5p↝, CSCs↓, EMT↓,
7893- IVT,    Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress
- vitro+vivo, Liver, NA
TumCG↓, Apoptosis↑, BAX↑, cl‑Casp3↑, cl‑PARP↑, Cyt‑c↑, TumAuto↑, LC3II↑, ATG3↑, ATG5↑, Beclin-1/ATG6↑, ER Stress↑, IRE1↑, XBP-1↑, CHOP/DDIT3↑, GRP78/BiP↑, *chemoPv↑,
7896- IVT,  VT,    Molecular targets of vitexin and isovitexin in cancer therapy: a critical review
- Review, Var, NA
chemoPv↑, Dose↝, ACE/ACE1↓, Ca+2↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Stroke↓, Apoptosis↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, TumAuto↑, HSP90↑, ER Stress↑, Hif1a↓, TumMeta↓, angioG↓, Tf↓, MAPK↓, PI3K↓, Akt↓, β-catenin/ZEB1↓, TumCCA↑, FOXO3↓, mTOR↓,
5116- JG,    Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells
- in-vitro, Melanoma, B16-BL6
GSH↓, ROS↑, chemoPv↑,
8098- KAE,    Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7
TumAuto↑, ER Stress↑, CHOP/DDIT3↓, chemoPv↑, RadioS↑, Akt↓, PI3K↓, ERK↓, ATG5↑, ATG7↑, Beclin-1/ATG6↑,
8175- Las,    Lasiodin Inhibits Proliferation of Human Nasopharyngeal Carcinoma Cells by Simultaneous Modulation of the Apaf-1/Caspase, AKT/MAPK and COX-2/NF-κB Signaling Pathways
- in-vitro, NPC, NA
tumCV↓, TumCMig↓, APAF1↑, Cyt‑c↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, p‑Akt↓, p‑ERK↓, p‑p38↓, p‑JNK↓, COX2/PTGS2↓, NF-kB↓, chemoPv↑,
8250- LCA,    Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A
- in-vivo, Hepat, NA
chemoPv↑, NQO1↑,
8210- LCA,    Licochalcone A-Induced Human Bladder Cancer T24 Cells Apoptosis Triggered by Mitochondria Dysfunction and Endoplasmic Reticulum Stress
- in-vitro, Bladder, T24/HTB-9
chemoPv↑, TumCP↓, ROS↑, Apoptosis↑, mtDam↑, Casp3↑, cl‑PARP↑, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, Casp12↑, mt-ROS↑, tumCV↓, GSH/GSSG↓, NA↓,
8292- lign,    Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives
- Review, Var, NA
*BioAv↝, chemoPv↑, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, *AntiDiabetic↑, *antiOx↑, *AntiCan↑, *Inflam↓, *cardioP↑, TumCCA↑, PSA↓, miR-106b↓, IGF-1↓, ERK↓, Akt↓, Bcl-2↓, p‑FAK↓, radioP↑, P-gp/ABCB1↓, ChemoSen↑, MMP↓, ROS↑, BioAv↓, *toxicity↓, chemoP↑,
8513- MAG,    Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I
- vitro+vivo, Oral, SCC4 - in-vitro, Tong, SCC9 - in-vitro, SCC, CAL27
TumCG↓, TumMeta↓, *toxicity↓, Ingr?, chemoPv↑, compI↓, mitResp↓, ETC↓, AMPK↑, STAT3↓, ox-PrxI↑, Dose↝, Ki-67↓, STAT3↓, P70S6K↓, HK2↓, survivin↓, BioAv↝, Half-Life↝, ROS↑,
8654- MBZ,  SUL,    Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model
- in-vivo, Colon, HT-29 - in-vitro, Colon, SW48
Synergy↑, COX2/PTGS2↓, angioG↓, VEGFR2/KDR/Flk1↓, Ki-67↓, chemoPv↑,
8741- MeSA,    In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention
- vitro+vivo, Var, NA
Apoptosis↑, eff↑, eff↝, chemoPv↑,
6538- MeSal,  ASA,    Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis
- in-vitro, CRC, NA
chemoPv↑, AMPK↑, NRF2↑, miR-34a↑, cMyc↓, tumCV↓, Apoptosis↑, TumCI↓, TumCMig↓, MET↑,
8618- MO,    Lemon Balm Extracts Prevent Breast Cancer Progression In Vitro and In Ovo on Chorioallantoic Membrane Assay
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, selectivity?, Ingr↝, Dose↝, eff?, angioG↓, chemoPv↑,
8912- MO,    Anticancer effect of Moringa oleifera in oral squamous cell carcinoma: a systematic review
- Review, Oral, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *chemoPv↑, *Ingr↝, *AntiDiabetic↑, *hepatoP↑, *Bacteria↓, *AntiFungal↑, Apoptosis↑, ROS↑, DNAdam↑, Casp3↑, TumCCA↑, ROS↓, chemoP↑,
8874- MOR,    The anticarcinogenic and anticancer effects of the dietary flavonoid, morin: Current status, challenges, and future perspectives
- Review, Var, NA
AntiCan↑, selectivity↑, *ROS↓, *Inflam↓, *p‑Akt↓, *NF-kB↓, ChemoSen↑, chemoPv↑, *toxicity↓, BioAv↑, BioAv↓, MRP1/ABCC1↝, BioAv↑, PCNA↓, hepatoP↑, NF-kB↓, TNF-α↓, IL6↓, PGE2↓, MMP2↓, MMP9↓, Apoptosis↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, FasL↑, FADD↑, ROS↑, MMP↓, BAX↑, Bcl-xL↓, Casp9↑, Casp3↑, EMT↓, Akt↓, Hippo↑,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
6490- Nimb,    Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer
- in-vitro, Oral, SCC4
PI3K↓, Akt↓, GSK‐3β↑, MMP↓, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, TumAuto↑, Beclin-1/ATG6↓, p62↑, PI3K↓, chemoPv↑,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
4970- Nimb,    Insights into Nimbolide molecular crosstalk and its anticancer properties
- Review, Var, NA
chemoPv↑, Apoptosis↑, TumCP↓, TumCD↑, TumMeta↓, angioG↓,
4628- OLE,    Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases
- in-vitro, Var, NA
chemoPv↑, TumCP↓, angioG↓, TumCI↓, TumMeta↓,
5072- PEITC,    Inhibition and Inactivation of Human Cytochrome P450 Isoforms by Phenethyl Isothiocyanate
- in-vitro, Nor, NA
*CYP2E1↓, *chemoPv↑,
4947- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G0/G1   Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
AntiCan↑, chemoPv↑, TumCG↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑,
4964- PEITC,    Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical
- in-vitro, Var, NA
GSH↓, GSTA1↓, chemoPv↑,
4931- PEITC,    Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Risk↓, miR-194↑, TumCI↓, MMP2↓, MMP9↓, BMP2↓, *chemoPv↑,
4934- PEITC,    Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
GSH↓, ROS↑, chemoPv↑, Apoptosis↑, Casp9↑, Casp3↑, eff↓, TumCG↓, TumCCA↑, BAX↑, Nrf1↑, GSH↓, GSSG↓, GSH/GSSG↓,
4937- PEITC,    PEITC: Functional Compound for Primary and Tertiary Chemoprevention of Cancer
- Review, Var, NA
chemoPv↑, tumCV↓, GSH↓, ROS↑, *toxicity↝,
4942- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
chemoPv↑, TumCG↓, TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑,
4969- PSO,    The Coumarin Psoralidin Enhances Anticancer Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
- in-vitro, Cerv, HeLa
AntiCan↑, chemoPv↑, TRAIL↑, selectivity↑, toxicity↓, MMP↓, Apoptosis↑,
44- QC,    Preclinical Colorectal Cancer Chemopreventive Efficacy and p53-Modulating Activity of 3′,4′,5′-Trimethoxyflavonol, a Quercetin Analog
- in-vivo, CRC, HCT116
P53↑, chemoPv↑, TumVol↓, TumCP↓, Apoptosis↑,
95- QC,    Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent
- in-vitro, Pca, PC3
p‑ERK↓, p‑STAT3↓, p‑Akt↓, N-cadherin↓, Vim↓, cycD1/CCND1↓, Snail↓, Slug↓, Twist↓, PCNA↓, EGFR↓, chemoPv↑,
82- QC,  ATG,    Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells
- in-vitro, Pca, LNCaP
AR↓, PI3K/Akt↓, miR-21↓, STAT3↓, BAD↓, PRAS40↓, GSK‐3β↓, PSA↓, NKX3.1↑, Bax:Bcl2↑, miR-19b↓, miR-148a↓, AMPKα↓, TumCP↓, chemoPv↑, TumCMig↓,
81- QC,  EGCG,    Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
- in-vivo, Pca, NA
COMT↓, MRP1/ABCC1↓, Ki-67↓, Bax:Bcl2↑, AR↓, Akt↓, p‑ERK↓, COMT↓, Synergy↑, chemoPv↑, BioAv↑,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4/6↓, E2Fs↓, PCNA↓, cDC2↓, PTEN↑, MSH2↑, P21↑, EP300↑, BRCA1↑, NF2↑, TSC1↑, TGFβR1↑, P53↑, RB1↑, AKT1↓, cMyc↓, CDC7↓, cycF↓, CDC16↓, CUL4B↑, CBP↑, TSC2↑, HER2/EBBR2↓, BCR↓, TumCCA↑, chemoPv↑,
4663- RES,    Exploring resveratrol’s inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models
- Review, Var, NA
*antiOx↑, *Inflam↓, *chemoPv↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, PI3K↓, Akt↓, mTOR↓, GSK‐3β↝, Snail↓, HH↓, p‑GSK‐3β↓, N-cadherin↓, EMT↓, CD133↓, CD44↓, ALDH1A1↓, OCT4↓, SOX4↓, Shh↓, Smo↓, Gli1↓, GLI2↓,
3056- RES,    Less is more for cancer chemoprevention: evidence of a non-linear dose response for the protective effects of resveratrol in humans and mice
- in-vivo, Nor, NA
*AMPK↑, *P21↑, *Dose↓, *chemoPv↑,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *chemoPv↑, ChemoSen↑, BioAv↑, Half-Life↝, COX2/PTGS2↓, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, P21↑, MMP9↓, NF-kB↓, Telomerase↓, PSA↓, MAPK↑, P53↑,
3071- RES,    Resveratrol and Its Anticancer Effects
- Review, Var, NA
chemoPv↑, SIRT1↑, Hif1a↓, VEGF↓, STAT3↓, NF-kB↓, COX2/PTGS2↓, PI3K↓, mTOR↓, NRF2↑, NLRP3↓, H2O2↑, ROS↑, P53↑, PUMA↑, BAX↑,
1511- RES,  Chemo,    Combination therapy in combating cancer
- Review, Var, NA
eff↑, *NRF2↑, *GSH↑, *ROS↓, chemoPv↑, ChemoSideEff↓,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,

Showing Research Papers: 101 to 150 of 172
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 172

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↓, 1,   Catalase↑, 2,   Fenton↑, 1,   GCLM↑, 1,   GPx↓, 1,   GSH↓, 8,   GSH↑, 3,   GSH/GSSG↓, 2,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 2,   H2O2↓, 1,   H2O2↑, 1,   HO-1↑, 2,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↑, 1,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 4,   Nrf1↑, 2,   NRF2↓, 4,   NRF2↑, 4,   Prx↓, 2,   ox-PrxI↑, 1,   RNS↑, 1,   ROS↓, 7,   ROS↑, 42,   ROS⇅, 2,   mt-ROS↑, 3,   selenoP↑, 1,   SOD↓, 2,   SOD↑, 2,   SOD2↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Mets↑, 1,   Tf↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR↓, 1,   CDC16↓, 1,   CDC25↓, 1,   compI↓, 2,   ETC↓, 1,   mitResp↓, 2,   mitResp↑, 1,   mtDam↑, 4,   OCR↓, 1,   OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMPK↑, 10,   ATP↓, 2,   FASN↓, 2,   glucose↓, 1,   Glycolysis↓, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 4,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   HK2↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   NADPH↑, 2,   PDK1 / PDPK1↓, 1,   PKM2↓, 1,   SCFAs↑, 1,   SIRT1↓, 2,   SIRT1↑, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 3,   Apoptosis↓, 1,   Apoptosis↑, 63,   BAD↓, 1,   Bak↑, 1,   BAX↑, 18,   Bax:Bcl2↑, 10,   Bcl-2↓, 20,   Bcl-xL↓, 3,   BID↑, 3,   cl‑BID↑, 1,   Casp↑, 5,   cl‑Casp↑, 1,   Casp12↑, 2,   Casp3↑, 30,   cl‑Casp3↑, 4,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 9,   cl‑Casp8↑, 1,   Casp9↑, 17,   cl‑Casp9↑, 3,   cFLIP↓, 1,   Cyt‑c↑, 23,   Diablo↑, 1,   DR5↑, 5,   FADD↑, 3,   Fap1↓, 1,   Fas↑, 1,   FasL↑, 3,   IAP1↓, 1,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 4,   Mcl-1↓, 6,   Mcl-1↑, 1,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p38↑, 3,   p‑p38↓, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 9,   TRAIL↑, 1,   TumCD↑, 4,   XIAP↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 30,   Akt↑, 1,   p‑Akt↓, 7,   AKT1↓, 1,   AMPKα↓, 1,   CDC7↓, 1,   CK2↓, 3,   cMET↓, 1,   EGFR↓, 8,   ERK↓, 7,   p‑ERK↓, 5,   FOXD3↑, 1,   HER2/EBBR2↓, 3,   Hippo↑, 1,   Hippo↝, 1,   IGF-2R↑, 1,   IKKα↓, 3,   IκB↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 3,   JNK↓, 1,   JNK↑, 7,   p‑JNK↓, 2,   MAPK↓, 6,   MAPK↑, 1,   mTOR↓, 12,   P70S6K↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 23,   PI3K/Akt↓, 2,   PRAS40↓, 1,   PTEN↑, 6,   RAS↓, 2,   Sp1/3/4↓, 4,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 16,   p‑STAT3↓, 4,   p‑STAT3↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

CBP↑, 1,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 4,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO3↓, 1,   FOXO3↑, 3,   HDAC↓, 7,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   HDAC8↓, 2,   HOTAIR↓, 1,   miR-106b↓, 2,   miR-10a-5p↝, 1,   miR-143↑, 1,   miR-148a↓, 1,   miR-155↝, 1,   miR-194↑, 1,   miR-19b↓, 2,   miR-200b↑, 2,   miR-21↓, 3,   miR-27a-3p↓, 1,   miR-29b↓, 1,   miR-34a↑, 3,   miR-34a↝, 1,   MYCN↓, 1,   OCT4↓, 1,   other↓, 2,   other↑, 1,   other↝, 2,   SOX4↓, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 3,   ER Stress↑, 10,   GRP78/BiP↑, 3,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 2,   NQO2↑, 1,   PDI↑, 1,   PERK↑, 1,   UPR↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 5,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   LC3II↑, 4,   p62↑, 2,   TumAuto↑, 9,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   CUL4B↑, 1,   DNAdam↑, 7,   DNArepair↓, 1,   hTERT/TERT↓, 2,   MSH2↑, 1,   NKX3.1↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 17,   p53 Wildtype↓, 2,   PARP↑, 1,   cl‑PARP↑, 14,   PCNA↓, 7,   Telomerase↓, 3,   TOP1↓, 2,   TOP2↓, 1,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 7,   CDK4↓, 8,   CDK4/6↓, 1,   CDK6↓, 5,   cellSen↑, 1,   Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 18,   CycD3↓, 1,   cycE/CCNE↓, 5,   cycF↓, 1,   E2Fs↓, 1,   Ki-67↓, 5,   P21↓, 2,   P21↑, 10,   p27/CDKN1B↑, 4,   pRB↑, 1,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA↑, 38,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   BMP2↓, 1,   CD133↓, 1,   CSCs↓, 6,   Diff↑, 2,   EP300↑, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 4,   HH↓, 3,   IGF-1↓, 4,   IGF-1↑, 1,   IGFBP1↑, 1,   IGFBP3↑, 1,   Ki-67↓, 5,   Let-7↑, 1,   mTORC1↓, 1,   NF2↑, 1,   NOTCH↓, 2,   NOTCH3↓, 1,   PTCH1↓, 2,   SCF↓, 2,   Shh↓, 3,   Smo↓, 2,   TumCG↓, 23,   TumCP↓, 35,   TumCP↑, 1,   Wnt↓, 11,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 3,   Ca+2↓, 1,   Ca+2↑, 11,   i-Ca+2?, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   E-cadherin↑, 6,   EMT↓, 13,   FAK↓, 4,   p‑FAK↓, 2,   GLI2↓, 2,   ITGB4↓, 1,   MET↑, 1,   MMP1↓, 2,   MMP2↓, 16,   MMP7↓, 1,   MMP9↓, 20,   MMPs↓, 7,   MUC4↓, 3,   N-cadherin↓, 7,   PDGF↓, 3,   Rac1↓, 1,   Rho↝, 1,   Slug↓, 2,   Snail↓, 4,   TIMP1↑, 2,   TIMP2↑, 3,   TSC1↑, 1,   TumCA↓, 1,   TumCI↓, 18,   TumCMig↓, 16,   TumMeta↓, 18,   TumMeta↑, 2,   Twist↓, 3,   uPA↓, 6,   Vim↓, 4,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 19,   p‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 29,   CD31/PECAM-1↓, 1,   HIF-1↓, 1,   Hif1a↓, 16,   Hif1a↑, 1,   NO↝, 1,   PGI2↓, 1,   VEGF↓, 20,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 2,   GLUT1↓, 3,   GLUT4↓, 1,   MMP↓, 23,   MMP↑, 2,   MPT↑, 3,   TRPV1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CD44↓, 1,   cDC2↓, 1,   COX2/PTGS2↓, 24,   CXCL12↓, 1,   CXCR2↓, 2,   CXCR4↓, 5,   DR4↑, 3,   HMGB1↓, 1,   ICAM-1↓, 1,   IL10↓, 1,   IL10↑, 1,   IL1α↓, 1,   IL1β↓, 3,   IL6↓, 6,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 11,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 30,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NLRP3↓, 1,   NLRP3↑, 1,   p‑p65↓, 1,   PD-L1↓, 1,   PGE2↓, 8,   PSA↓, 7,   RAGE↓, 1,   TCF↓, 1,   TLR4↝, 1,   TNF-α↓, 6,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PRNP↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 3,   ACE/ACE1↓, 1,   AR↓, 7,   AR↝, 2,   AR-V7?, 1,   COMT↓, 2,   CYP19?, 1,   ER-α36↝, 1,   ER(estro)↓, 1,   Estro↝, 1,   PPARα↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 8,   BioAv↑, 12,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 35,   ChemoSen∅, 1,   CompStab↓, 2,   CompStab↑, 1,   CYP1A1↓, 3,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP1B1↓, 1,   CYP3A4↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 17,   eff?, 1,   eff↓, 5,   eff↑, 14,   eff↝, 4,   GSTA1↓, 1,   Half-Life↓, 1,   Half-Life↝, 3,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 3,   P-gp/ABCB1⇅, 1,   P450↓, 1,   RadioS↑, 12,   selectivity?, 1,   selectivity↑, 22,   Synergy↑, 15,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 7,   AR↝, 2,   ascitic↓, 1,   AST↓, 1,   BRCA1↑, 1,   creat↓, 1,   EGFR↓, 8,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 2,   IL6↓, 6,   LDH↓, 1,   PD-L1↓, 1,   PSA↓, 7,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 24,   AntiDiabetic↑, 1,   antiNeop↑, 1,   AntiTum↑, 5,   cardioP↑, 2,   chemoP↑, 6,   chemoPv↑, 138,   chemoPv⇅, 1,   ChemoSideEff↓, 1,   hepatoP↑, 4,   mal↓, 1,   memory↑, 1,   Nausea↓, 1,   neuroP↑, 5,   OS↑, 1,   Pain↓, 1,   QoL↑, 2,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 10,   TGFβR1↑, 1,   toxicity↓, 6,   toxicity↝, 3,   TumVol↓, 4,   TumW↓, 1,   Vomit↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 1,  
Total Targets: 477

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 27,   Catalase↓, 1,   Catalase↑, 3,   GPx↓, 1,   GPx↑, 3,   GSH↑, 9,   GSTs↑, 3,   HO-1↑, 2,   lipid-P↓, 5,   MDA↓, 3,   NQO1↑, 2,   NRF2↑, 7,   RNS↓, 2,   ROS?, 2,   ROS↓, 30,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 4,   TrxR↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 5,   ALAT↓, 1,   AMPK↑, 2,   ATP↑, 1,   ATP↝, 1,   glucose↓, 1,   LDL↓, 1,   lipidLev↓, 1,   NAD↝, 1,   NADPH↑, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 1,   Casp3∅, 1,   Casp9↓, 1,   Cyt‑c∅, 1,   iNOS↓, 3,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↓, 1,   p‑CREB↑, 1,   ERK↑, 1,   JNK↓, 1,   MAPK↓, 2,   MAPK↑, 1,   PKCδ↓, 1,   RAS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 2,   other↝, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 6,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 2,   EMT↓, 1,   MMP9↓, 1,   serineP↓, 1,   TGF-β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   MMP∅, 2,   TRPV1↑, 1,   TRPV3↑, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 9,   IL18↓, 1,   IL1β↓, 3,   IL2↑, 1,   IL4↑, 1,   IL6↓, 3,   IL8↓, 1,   Imm↑, 5,   Inflam↓, 34,   Inflam↑, 1,   NF-kB↓, 10,   PGE2↓, 1,   TNF-α↓, 7,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 2,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↓, 1,   PPARα↑, 1,   p‑PPARγ↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 10,   BioAv⇅, 2,   BioAv↝, 10,   CompStab↝, 1,   CYP2E1↓, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 7,   eff↑, 9,   GSTA1↑, 1,   Half-Life?, 1,   Half-Life↓, 1,   Half-Life↝, 4,   selectivity↑, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   BMD↑, 1,   BP↓, 2,   Calcium↑, 1,   CRP↓, 1,   hs-CRP↓, 1,   IL6↓, 3,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 3,   AntiCan↓, 1,   AntiCan↑, 3,   AntiDiabetic↓, 1,   AntiDiabetic↑, 10,   cardioP↑, 8,   cardioP⇅, 1,   chemoP↑, 2,   chemoPv↑, 34,   ChemoSideEff↓, 1,   cognitive↑, 3,   hepatoP↑, 10,   memory↑, 4,   neuroP↑, 11,   Obesity↓, 2,   OS↑, 1,   Pain↓, 3,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 2,   Stroke↓, 1,   toxicity↓, 8,   toxicity↝, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   Bacteria↓, 6,   Diar↓, 1,   GutMicro↑, 1,   GutMicro∅, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 153

Scientific Paper Hit Count for: chemoPv, ChemoPreventive
8 Curcumin
7 Phenethyl isothiocyanate
6 Chemotherapy
6 Capsaicin
6 Chrysin
6 Resveratrol
6 Quercetin
6 Sulforaphane (mainly Broccoli)
4 Apigenin (mainly Parsley)
4 Diindolylmethane
4 Indole-3-carbinol
4 D-limonene
4 Fisetin
4 Nimbolide
4 Thymoquinone
3 EGCG (Epigallocatechin Gallate)
3 Betulinic acid
3 Chlorophyllin
3 Chocolate
3 α-Santalol/Sandalwood oil
2 Astaxanthin
2 Arctigenin
2 Biochanin A
2 Carvacrol
2 Celecoxib
2 Cucurbitacin
2 methylseleninic acid
2 Genistein (soy isoflavone)
2 Eugenol
2 Formononetin
2 Grapeseed extract
2 Hibiscus sabdariffa
2 Inositol
2 phytic acid, Inositol hexakisphosphate
2 Isovitexin
2 Vitexin
2 Licochalcone A
1 Annona atemoya Seed Extract
1 Silver-NanoParticles
1 probiotics
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Luteolin
1 Ashwagandha(Withaferin A)
1 Berberine
1 Beta-Caryophyllene
1 Boron
1 Boswellia (frankincense)
1 Bruteridin(bergamot juice)
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Calcium
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Chlorogenic acid
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Crocetin
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Deguelin
1 Diclofenac
1 Dandelion Root
1 Ginkgo biloba-EGb 761
1 5-fluorouracil
1 Garcinol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Honokiol
1 Hops (Humulus lupulus)
1 Hyperoside
1 Inulin Prebiotic
1 Isoliquiritigenin
1 isoflavones
1 Juglone
1 Kaempferol
1 Lasiodin
1 SDG/lignans
1 Magnolol
1 mebendazole
1 Sulindac
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Morin
1 Oleuropein
1 Psoralidin
1 Rutin
1 buckwheat sprouts
1 Selenium
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Selenite (Sodium)
1 Sutherlandioside D
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1417  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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