iNOS Cancer Research Results

iNOS, Inducible nitric oxide synthase: Click to Expand ⟱
Source: HalifaxProj(block)
Type:
An enzyme that produces nitric oxide (NO) in response to inflammatory stimuli.
iNOS can promote tumor growth by enhancing blood flow and nutrient supply to tumors through vasodilation. It may also help cancer cells evade apoptosis (programmed cell death).
Immune Activation: In some contexts, NO produced by iNOS can enhance the immune response against tumors, promoting the activation of immune cells that can target and destroy cancer cells.
Inhibition of Tumor Growth: High levels of NO can induce cytotoxic effects on tumor cells, leading to reduced proliferation and increased apoptosis.
Scientific Papers found: Click to Expand⟱
7896- IVT,  VT,    Molecular targets of vitexin and isovitexin in cancer therapy: a critical review
- Review, Var, NA
chemoPv↑, Dose↝, ACE/ACE1↓, Ca+2↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Stroke↓, Apoptosis↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, TumAuto↑, HSP90↑, ER Stress↑, Hif1a↓, TumMeta↓, angioG↓, Tf↓, MAPK↓, PI3K↓, Akt↓, β-catenin/ZEB1↓, TumCCA↑, FOXO3↓, mTOR↓,
7888- IVT,    Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways
- vitro+vivo, Nor, NA
*Inflam↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Apoptosis↓, *p‑MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *ICAM-1↓, *VCAM-1↓, *MPO↓, *MDA↓, *GSH↑, *SOD↑,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
8255- LCA,    Antitumor and antimetastatic effects of licochalcone A in mouse models
- in-vivo, Colon, NA
COX2/PTGS2↓, iNOS↓, NF-kB↓, AP-1↓, AntiTum↑, β-catenin/ZEB1↓, OS↑, TumMeta↓, MMP9↓,
8290- LE,    Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells
- vitro+vivo, Pca, DU145
*toxicity↝, Apoptosis↑, TumCCA↑, TumCMig↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, COX2/PTGS2↓, VEGF↓, MMP9↓, ICAM-1↓, VCAM-1↓,
8284- LE,    Glycyrrhizic acid from licorice down-regulates inflammatory responses via blocking MAPK and PI3K/Akt-dependent NF-κB signalling pathways in TPA-induced skin inflammation
- in-vivo, Nor, NA
*Ingr↝, *iNOS↓, *COX2/PTGS2↓, *IκB↓, *p65↓, *ERK↓, *p38↓, *MAPK↓, *PI3K↓, *Akt↓, *NF-kB↓,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8379- LT,    Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *ROS↓, *Apoptosis↓, *BioAv↓, *BBB∅, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, *Aβ↓, *memory↑, *neuroG↑, *NRF2↑, *NLRP3↓, *ROS↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↝, GranB/GZMB↝, hepatoP↑, *Learn↑, *TNF-α↓, *IL1β↓, *IL6↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *ER Stress↓, *GRP78/BiP↓, *IRE1↓, *cognitive↑, *BAX↓, *Bcl-2↓, *Casp3↓, *PSD95↑, *SNAP25↑, *JNK↓, *eff↑, *mtDam↓, *MMP↑, *Stroke↓, *TJ↑, *MMP9↓, *BBB∅, *NeuroI↓,
8390- LT,    Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective
- Review, IBD, NA - Review, CRC, NA
*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
8350- Lut,    The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activation
- in-vitro, Nor, NA
*H2O2↓, *NF-kB↓, *iNOS↓, *TNF-α↓, *IL1β↓, *COX2/PTGS2↓, *PI3K↓, *PTEN↓, *NF-kB↓, *Akt↓,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27/CDKN1B↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2/PTGS2↓, lipid-P↓, GSH↑, NRF2↑,
3278- Lyco,    Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells
- in-vitro, Colon, SW480
TNF-α↓, IL1β↓, IL6↓, iNOS↓, COX2/PTGS2↓, PGE2↓, NO↓, NF-kB↓, JNK↓, Inflam↓, MPO↓,
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2/PTGS2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
1089- MAG,    Magnolol potently suppressed lipopolysaccharide-induced iNOS and COX-2 expression via downregulating MAPK and NF-κB signaling pathways
- in-vitro, AML, RAW264.7
p‑IκB↓, NF-kB↓, p‑ERK↓, p‑JNK↓, p‑PI3K↓, p‑Akt↓, iNOS↓, COX2/PTGS2↓,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
9284- Maqui,    Antioxidant and anti-inflammatory effects of extracts from Maqui berry Aristotelia chilensis in human colon cancer cells
- in-vitro, CRC, HT-29 - in-vitro, Colon, Caco-2
COX2/PTGS2↓, NF-kB↓, Inflam↓, chemoP↑, TumCG↓, NO↓, iNOS↓, Dose↝, *lipid-P↓, *cardioP↑,
2253- MF,    Low-frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury
- in-vivo, Nor, NA
*Inflam↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *iNOS↓, *ROS↓, Catalase↑, *SOD↑, *HSP70/HSPA5↑, *neuroP↑, *motorD↑, *antiOx↑,
4116- MF,    Low‑frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury
- in-vivo, Nor, NA
*Inflam↓, *TNF-α↓, *IL1β↓, *iNOS↓, *ROS↓, *Catalase↑, *SOD↑, HSP70/HSPA5↑,
3468- MF,    An integrative review of pulsed electromagnetic field therapy (PEMF) and wound healing
- Review, Nor, NA
*other↑, *necrosis↓, *IL6↑, *TGF-β↑, *iNOS↑, *MMP2↑, *MCP1/CCL2↑, *HO-1↑, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *BioAv↑, eff⇅, DNAdam↑, Apoptosis↑, ROS↑, TumCP↓, *ROS↓, *FGF↑,
204- MFrot,  MF,    Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
- in-vivo, AD, NA
*NF-kB↓, *MAPK↓, *TLR4↓, *memory↑, *cognitive↑, *TGF-β1↑, *ARG1/2↑, *IL4↑, *IL10↑, *IL6↓, *IL1↓, *TNF-α↓, *iNOS↓, *ROS↓, *NO↓, *MyD88↓, *p‑IKKα↓, *p‑IκB↓, *p‑p65↓, *p‑JNK↓, *p‑p38↓, *ERK↓, *neuroP↑, *Aβ↓,
9157- MG, MIC-1,    Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice
- in-vivo, Col, NA
*colonLen↑, *TNF-α↓, *NO↓, *MPO↓, *IL1↓, *IL6↓, *iNOS↓, *CLDN1↑, *ZO-1↑, *GSTP1/GSTπ↑, *NRF2↑, *eff↑,
1777- MLT,    Melatonin as an antioxidant: under promises but over delivers
- Review, Var, NA
*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, Synergy↑,
8675- MLT,    Melatonin combined with antineoplastic drugs or natural products for cancer treatment: An update
- Review, Var, NA
ChemoSen↑, TumCP↓, TumCMig↓, CSCs↓, MDR1↓, chemoP?, IL1β↓, IL6↓, IL8↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, Bcl-2↓, Mcl-1↓, IAP1↓, survivin↓, PCNA↓, Ki-67↓, CC(CDKs/cyclins)↓, TumCMig↓, TumCI↓, Fibronectin↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, Synergy↑, Synergy↑, OCT4↓, Nanog↓, ERCC1↓, P-gp/ABCB1↓, EMT↓, Synergy↑, ChemoSen↑,
8917- MO,    Harnessing Moringa oleifera for Immune Modulation in Cancer: Molecular Mechanisms and Therapeutic Potential
- Review, Var, NA
*Ingr↝, *Inflam↓, *TNF-α↓, *IL1β↓, *iNOS↓, *PGE2↓, *PPARγ↑, pol-TregCell↓, NK cell↑, CD8+↑, CD4+↑, *GutMicro↑, Imm↑, TumCMig↓, TumMeta↓, Synergy↑, *toxicity↓, Apoptosis↑, TumCCA↑,
8875- MOR,    Neuroprotective Effect of Morin Against Chemical-Induced Neurotoxicities and Neurodegenerative Disease Models
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *chemoP↑, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *ROS↓, *MDA↓, *NO↓, *TLR4↓, *NF-kB↓, *ERK↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *Synergy↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
8960- mushLions,    Recent Advances in Erinacine A: Preparation, Biological Activities, and Biosynthetic Pathway
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *NGF↑, *other↝, *antiOx↑, *Inflam↓, *antiCG↑, *Bacteria↓, *hyperG↝, *AntiDiabetic↑, *AntiCan↑, *neuroG↑, *cognitive↑, *Stroke↓, *IL1β↓, *IL6↓, *TNF-α↓, *RNS↓, *iNOS↓, *MAPK↓, *CHOP/DDIT3↓, TumCD↓, ROS↑, TumCP↓, TumCI↓, ROCK1↓, LIMK2↓, Cofilin↓, PI3K↓, mTOR↓, P70S6K↓, TumCMig↓, TumMeta↓, TGF-β↓, MMP9↓, *AntiAge↑, *RIP1↓, *cl‑Casp8↓, *cl‑Casp3↓, *NRF2↑, *HO-1↑, *SOD1↑,
4647- OLEC,    Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer
- Review, Var, NA
*Inflam↓, AntiCan↑, *COX2/PTGS2↓, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓, TumCP↓, *AntiAg↑, mTOR↓, STAT3↓, ERK↓, p‑Akt↓, Bcl-2↓, ROS↑, PSA↓,
8449- OM,    Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties
- in-vitro, BC, MDA-MB-231
antiOx↑, ROS↑, TumCP↓, TumCCA↑, p‑p38↑, P21↑, Ki-67↓, eff↓, Apoptosis↑, Casp3↑, STAT3↑, P53↑, TumCMig↓, TumCI↓, FAK↓, iNOS↓, angioG↓,
8451- Oreg,    A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats
- in-vivo, AD, NA
*Learn↑, *memory↑, *AChE↓, *ROS↓, *COX2/PTGS2↓, *iNOS↓,
9054- PatchO,    Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis
- in-vivo, Col, NA
*TNF-α↓, *IFN-γ↓, *IL1β↓, *IL6↓, *IL17↓, *iNOS↓, *COX2/PTGS2↓, *TJ↑, *ZO-1↑, *CLDN1↑, *OCLN↑, *MUC1↑, *MUC2↑, *Inflam↓, *IBI↑,
2035- PB,    Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease
- in-vitro, Nor, glial - in-vivo, NA, NA
*ROS↓, *Inflam↑, *P21↓, *antiOx↑, *GSH↑, *NF-kB↓, *neuroP↑, *HDAC↓, *iNOS↓, *TNF-α↓, *IL1β↓, *LDL↓, ROS↓,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1/CCL2↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, Synergy↑, Synergy↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
1680- PBG,    Protection against Ultraviolet A-Induced Skin Apoptosis and Carcinogenesis through the Oxidative Stress Reduction Effects of N-(4-bromophenethyl) Caffeamide, a Propolis Derivative
- in-vitro, Nor, HS68
*ROS↓, *NRF2↑, *HO-1↑, *cJun↓, *MMP1↓, *MMP2↓, *p‑cJun↓, *cFos↓, *BAX↓, *Casp3↓, *DNAdam↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *PGE2↓, *NO↓,
1682- PBG,    Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits
- Review, Var, NA
i-LDH↓, Akt↓, MAPK↓, NF-kB↓, IL1β↓, IL6↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, ROS↓, Bcl-2↓, PARP↓, P53↑, BAX↑, Casp3↑, TumCCA↑, Cyt‑c↑, MMP↓, eff↑,
7831- PCA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *neuroP↑, *Aβ↓, *p‑tau↓, *autophagy↓, *GSK‐3β↓, *NeuroI↓, *iNOS↓, *COX2/PTGS2↓, *BDNF↑, *MEF2D↑, *cognitive↑, *memory↑,
5187- PEITC,    Phenethyl Isothiocyanate Inhibits Migration and Invasion of Human Gastric Cancer AGS Cells through Suppressing MAPK and NF-κB Signal Pathways
- in-vitro, GC, AGS
TumMeta↓, ERK↓, MKK7↓, PKCδ↓, Rho↓, uPA↓, MMP2↓, MMP9↓, RAS↓, VEGF↓, FAK↓, iNOS↓, COX2/PTGS2↓, TumCP↓,
4220- PI,    Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination
- in-vivo, AD, NA - in-vivo, MS, NA
*memory↑, *iNOS↓, *NRF2↑, *HO-1↑, *TAC↑, *TNF-α↓, *IL1β↓, *NF-kB↓, *IL10↑, *FOXP3↑, *BDNF↑, other↑,
2971- PL,    Piperlongumine attenuates IL-1β-induced inflammatory response in chondrocytes
- in-vitro, OS, NA
*NO↓, *PGE2↓, *iNOS↓, *COX2/PTGS2↓, *MMP3↑, *MMP13↓, *Inflam↓,
3918- PTS,    Pterostilbene inhibits amyloid-β-induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase-1 inflammasome pathway
- in-vitro, AD, BV2
*IL6↓, *IL1β↓, *TNF-α↓, *NLRP3↓, *Inflam↓, *NO↓, *iNOS↓,
3929- PTS,    New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
- Review, Var, NA - Review, Arthritis, NA
*NRF2↑, *BioAv↑, *ROS↓, *Inflam↓, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *hepatoP↑, *neuroP↑, *iNOS↓, *COX2/PTGS2↓, TumMeta↓, SOD2↓, ROS↑, TumCI↓, TumCG↓, HDAC1↓, PTEN↑, BP↓, *GutMicro↑,
5034- PTS,    Pterostilbene in Cancer Therapy
- Review, Var, NA
BioAv↓, Half-Life↓, iNOS↓, Apoptosis↑, STAT3↓, Akt↓, mTOR↓, NF-kB↓, NRF2↓, ChemoSen↑, BBB↑,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *lipid-P↓, *antiOx↑, *Aβ↓, *Inflam↓, *BBB↝, *NF-kB↓, *iNOS↓, *memory↑, *cognitive↑, *AChE↓, *MMP↑, *ROS↓, *ATP↑, *AMPK↑, *NADPH↓, *p‑tau↓,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
3361- QC,    Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats
- in-vivo, Nor, NA - in-vitro, NA, NA
*BG↓, *ROS↓, *SOD↑, *MDA↓, *ER Stress↓, *iNOS↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *antiOx↓, *Inflam↓, *JAK2↑, *STAT3?,

Showing Research Papers: 101 to 150 of 198
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 198

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 3,   Catalase↓, 1,   Catalase↑, 3,   GPx↑, 1,   GPx4↓, 2,   GSH↓, 9,   GSH↑, 2,   GSTs↑, 1,   H2O2↓, 1,   HO-1↓, 4,   HO-1↑, 6,   HO-2↓, 1,   Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 2,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 2,   MPO↓, 4,   NQO1↑, 1,   NRF2↓, 3,   NRF2↑, 11,   ROS↓, 12,   ROS↑, 50,   ROS⇅, 4,   SOD↑, 6,   SOD2↓, 1,   Thiols↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 3,   compIV↓, 1,   EGF↓, 1,   mitResp↓, 1,   MKK7↓, 2,   mtDam↑, 4,   OCR↓, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 4,   ACSL4↑, 1,   ALAT↓, 1,   ALAT↝, 1,   AMPK↓, 1,   AMPK↑, 3,   p‑AMPK↑, 1,   ATP↓, 3,   ECAR↝, 1,   FASN↓, 1,   GlucoseCon↓, 1,   GlutMet↓, 1,   Glycolysis↓, 5,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   HK2↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   LDL↓, 1,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PFK↓, 1,   PKM2↓, 2,   PLA2↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↑, 40,   BAD↓, 1,   BAD↑, 1,   Bak↓, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 24,   Bax:Bcl2↑, 3,   Bcl-2↓, 30,   Bcl-xL↓, 7,   BID↓, 1,   BID↑, 3,   BIM↑, 1,   BNIP3↑, 1,   Casp↑, 6,   Casp↝, 1,   Casp1↑, 1,   Casp10↑, 1,   Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 31,   cl‑Casp3↑, 3,   Casp7↑, 3,   cl‑Casp7↑, 1,   Casp8↑, 9,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 20,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 18,   Diablo↑, 3,   DR5↑, 6,   Endon↑, 1,   Fap1↓, 1,   Fas↑, 6,   Ferroptosis↑, 2,   GranB/GZMB↝, 1,   IAP1↓, 3,   ICAD↓, 1,   iNOS↓, 55,   iNOS↑, 3,   Mcl-1↓, 7,   MDM2↓, 2,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 2,   p‑p38↑, 1,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↑, 1,   survivin↓, 14,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↓, 2,   XIAP↓, 7,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 28,   Akt↑, 2,   p‑Akt↓, 8,   cMET↓, 2,   EGFR↓, 7,   EGFR↑, 1,   ERK↓, 13,   ERK↑, 1,   p‑ERK↓, 5,   GRB2↓, 1,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IKKα↓, 1,   p‑IκB↓, 1,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 2,   JNK↓, 4,   JNK↑, 4,   p‑JNK↓, 1,   MAPK↓, 7,   MAPK↑, 3,   MEK↓, 1,   MKK4↓, 1,   mTOR↓, 17,   p‑mTOR↓, 2,   P70S6K↓, 3,   PI3K↓, 23,   p‑PI3K↓, 1,   PI3K/Akt↓, 1,   PKA↓, 1,   PKCδ↓, 4,   PTEN↑, 7,   RAS↓, 4,   SHP1↑, 1,   Sp1/3/4↓, 2,   Src↓, 1,   STAT↓, 2,   STAT3↓, 22,   STAT3↑, 1,   p‑STAT3↓, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   CBP↓, 1,   cJun↓, 3,   p‑cJun↓, 1,   cMyc↓, 7,   p‑cMyc↑, 1,   DNMT1↓, 4,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO3↝, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   HDAC↓, 5,   HDAC1↓, 3,   HDAC6↓, 1,   HDAC8↓, 1,   Matr↓, 1,   miR-125b↓, 1,   miR-21↓, 1,   miR-34a↓, 1,   Myc↓, 2,   MYCN↓, 1,   OCT4↓, 3,   other↓, 3,   other↑, 4,   other↝, 1,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 1,   SOX9↓, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 12,   GRP78/BiP↑, 2,   HSP27↓, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 4,   HSP90↑, 1,   HSPs↓, 1,   NQO2↑, 1,   PERK↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 6,   p62↓, 4,   p62↑, 1,   TumAuto↑, 8,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 14,   ERCC1↓, 1,   hTERT/TERT↓, 3,   p16↑, 1,   P53?, 1,   P53↓, 1,   P53↑, 28,   P53↝, 1,   PARP↓, 2,   PARP↑, 6,   cl‑PARP↑, 9,   PARP1↑, 1,   PCNA↓, 7,   SIRT6↑, 1,   Telomerase↓, 4,   TOP1↓, 1,   TOP2↓, 1,   TP53↓, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 1,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 9,   CDK4↓, 9,   CDK4/6↓, 1,   CDK6↓, 6,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 2,   Chk2↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 25,   cycE/CCNE↓, 6,   cycE/CCNE↑, 2,   E2Fs↓, 2,   E2Fs↑, 1,   Ki-67↓, 5,   P21↓, 3,   P21↑, 16,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 2,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA↓, 1,   TumCCA↑, 36,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   CD133↑, 1,   cFos↓, 1,   CSCs↓, 8,   FGF↓, 1,   IGF-1?, 1,   IGF-1↓, 1,   Ki-67↓, 5,   mTORC1↓, 1,   Nanog↓, 2,   NICD↓, 1,   NOTCH↓, 3,   NOTCH1↓, 6,   NOTCH1↑, 1,   p300↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 11,   TumCG↑, 1,   TumCP↓, 27,   Wnt↓, 4,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↓, 1,   AP-1↓, 3,   ASAP2↓, 1,   Ca+2↓, 1,   Ca+2↑, 5,   Ca+2↝, 2,   i-Ca+2?, 1,   cal2↓, 1,   CCN2/CTGF↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 7,   EMT↓, 9,   EpCAM↓, 1,   FAK↓, 4,   p‑FAK↓, 2,   Fibronectin↓, 2,   ITGA5↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   MMP-10↓, 2,   MMP1↓, 1,   MMP2↓, 19,   MMP3↓, 3,   MMP7↓, 8,   MMP9↓, 29,   MMPs↓, 10,   N-cadherin↓, 8,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 1,   ROCK1↑, 1,   Slug↓, 4,   SMAD3↓, 1,   Snail↓, 6,   TET1↑, 1,   TGF-β↓, 4,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↑, 4,   pol-TregCell↓, 1,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 17,   TumCMig↓, 21,   TumMeta↓, 16,   TumMeta↑, 1,   Twist↓, 5,   uPA↓, 4,   Vim↓, 9,   Zeb1↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   angioG↑, 1,   CD31/PECAM-1↓, 2,   Endoglin↑, 1,   eNOS↑, 2,   HIF-1↓, 1,   Hif1a↓, 19,   LOX1↓, 1,   NO↓, 8,   VCAM-1↓, 1,   VEGF↓, 29,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   CLDN2↓, 1,   MMP↓, 19,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 3,   CD8+↑, 1,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 46,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 5,   CXCR4↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 6,   IL1↓, 5,   IL10↓, 7,   IL12↓, 2,   IL1β↓, 12,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 1,   IL4↓, 2,   IL6↓, 22,   IL8↓, 7,   Imm↑, 3,   Inflam↓, 15,   LRIG1↑, 1,   M1↓, 1,   MCP1/CCL2↓, 1,   mPGES-1↓, 1,   NAF1↓, 1,   NF-kB↓, 43,   NF-kB↑, 5,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 3,   p65↓, 3,   PD-L1↓, 2,   PGE2↓, 8,   PSA↓, 2,   RAGE↓, 1,   TLR4↓, 4,   TNF-α↓, 24,   TNF-α↑, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 2,   PPARα↓, 1,   PPARγ↑, 2,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 5,   BioAv↑, 2,   BioAv↝, 2,   BioEnh↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 20,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1B1↑, 1,   Dose↑, 2,   Dose↝, 8,   Dose∅, 7,   eff↓, 2,   eff↑, 19,   eff⇅, 1,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   P-gp/ABCB1⇅, 1,   P450↓, 2,   RadioS↑, 7,   selectivity↑, 9,   Synergy↑, 22,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALAT↝, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 2,   AST↝, 1,   BP↓, 1,   BRCA1↓, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 7,   EGFR↑, 1,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 3,   IL6↓, 22,   LDH↓, 4,   i-LDH↓, 1,   Myc↓, 2,   PD-L1↓, 2,   PSA↓, 2,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 13,   antiNeop↑, 1,   AntiTum↑, 4,   cardioP↑, 3,   chemoP?, 1,   chemoP↑, 9,   chemoPv↑, 6,   ChemoSideEff↓, 1,   cognitive?, 1,   cognitive↑, 1,   hepatoP↑, 4,   neuroP↑, 2,   OS↑, 2,   RenoP↑, 3,   Risk↓, 4,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  
Total Targets: 523

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

3-NT↓, 1,   antiOx↓, 4,   antiOx↑, 62,   ARE↑, 2,   Bil↑, 2,   Catalase↑, 35,   Copper↓, 1,   Fenton↓, 3,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 23,   GSH↑, 44,   GSR↓, 2,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 8,   H2O2↓, 3,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 40,   HO-1⇅, 1,   hyperG↝, 1,   Iron↓, 1,   Keap1↓, 5,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 35,   MDA↓, 44,   MPO↓, 10,   NOX↓, 1,   NOX1↓, 1,   NOX2↓, 1,   NOX4↓, 3,   NQO1↑, 9,   NRF2↓, 1,   NRF2↑, 56,   Prx↑, 2,   RNS↓, 5,   ROS↓, 106,   ROS↑, 2,   ROS⇅, 1,   SOD↓, 1,   SOD↑, 58,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 6,   TBARS↓, 5,   Trx↑, 2,   Trx1↑, 1,   TrxR↑, 2,   uricA↓, 2,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   Insulin↑, 1,   mtDam↓, 2,   mtDam↑, 1,   PGC-1α↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 3,   ACC↑, 1,   adiP↑, 1,   ALAT↓, 11,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 6,   p‑AMPK↑, 1,   ATP↓, 1,   ATP↑, 5,   cAMP↑, 2,   CRM↑, 1,   FABP4↓, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↑, 2,   GSK‐3β↓, 5,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 1,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 3,   NADPH↑, 1,   PKM2↓, 1,   SIRT1↓, 1,   SIRT1↑, 7,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   APAF1↓, 1,   Apoptosis↓, 18,   BAX↓, 12,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 6,   Casp1↓, 3,   Casp3↓, 15,   Casp3↑, 1,   Casp3∅, 2,   cl‑Casp3↓, 2,   Casp6↓, 1,   Casp8↓, 1,   cl‑Casp8↓, 1,   Casp9↓, 8,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 4,   Cyt‑c∅, 2,   Fas↓, 3,   Ferroptosis↓, 1,   iNOS↓, 138,   iNOS↑, 6,   necrosis↓, 2,   p38↓, 7,   p38↑, 1,   p‑p38↓, 3,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   Akt↑, 7,   AMPKα↑, 1,   CREB↑, 1,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 7,   ERK↑, 3,   p‑ERK↓, 3,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   p‑IKKα↓, 1,   IκB?, 1,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 1,   p‑JAK1↓, 1,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 9,   JNK↑, 2,   p‑JNK↓, 4,   MAPK?, 1,   MAPK↓, 16,   MAPK↑, 3,   p‑MAPK?, 1,   p‑MAPK↓, 2,   MEK↓, 1,   mTOR↑, 1,   PDGFR-BB↓, 1,   PI3K↓, 6,   PI3K↑, 3,   PKA↑, 1,   PKCδ?, 1,   PKCδ↓, 1,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 1,   RIP1↓, 1,   Sp1/3/4↑, 1,   STAT↓, 2,   STAT3?, 1,   STAT3↓, 1,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 2,   cJun↓, 3,   p‑cJun↓, 1,   cMyc↓, 1,   HDAC↓, 2,   HDAC↑, 1,   MEF2D↑, 1,   miR-34a↓, 1,   OCT4↓, 1,   other↓, 2,   other↑, 2,   other↝, 4,   SOX9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   ER Stress↓, 5,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 7,   HSPs↑, 1,   IRE1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↓, 1,   Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 4,   PARP∅, 1,   cl‑PARP↓, 1,   Telomerase↓, 2,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   P21↓, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   cFos↓, 1,   Diff↝, 1,   EP2↓, 1,   FGF↑, 1,   neuroG↑, 2,   p‑STAT1↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 4,   AP-1↓, 3,   ARG1/2↑, 2,   Ca+2↓, 5,   Ca+2↝, 1,   Cartilage↑, 4,   COL1↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 4,   MMP2↑, 1,   MMP3↓, 1,   MMP3↑, 1,   MMP9↓, 6,   MMPs↓, 3,   MMPs↑, 1,   MUC1↑, 2,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 3,   TGF-β↑, 2,   TGF-β1↓, 1,   TGF-β1↑, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TumCI↓, 1,   TXNIP↓, 2,   uPA↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   eNOS↓, 1,   p‑eNOS↑, 1,   Hif1a↓, 4,   NO↓, 42,   NO↑, 1,   VCAM-1↓, 6,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↑, 15,   BBB↝, 2,   BBB∅, 2,   CLDN1↑, 3,   CLDN3↑, 1,   GastroP↑, 2,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 3,   memfluid↑, 1,   MMP↑, 10,   MMP∅, 1,   MUC2↑, 1,   NHE3↑, 1,   OATPs↓, 1,   OCLN↑, 2,   TJ↑, 2,   VGSC↓, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 3,   CD19↑, 1,   CD4+↑, 2,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 92,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 5,   IFN-γ↓, 8,   IL1↓, 6,   IL10↓, 5,   IL10↑, 6,   IL12↓, 4,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 62,   IL1β↑, 1,   IL2↓, 7,   IL4↓, 3,   IL4↑, 2,   IL6↓, 70,   IL6↑, 2,   IL8↓, 7,   Imm↓, 1,   Imm↑, 1,   Imm↝, 1,   INF-γ↓, 2,   Inflam↓, 97,   Inflam↑, 2,   IP-10/CXCL-10↓, 2,   IRF3↓, 2,   LTA/TNF-β↓, 1,   MCP1/CCL2↓, 5,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 1,   MyD88↓, 3,   NeuroI↓, 5,   NF-kB↓, 78,   NF-kB↑, 1,   p‑NF-kB↓, 2,   NK cell↑, 1,   NLRP3↓, 15,   p65↓, 2,   p‑p65↓, 1,   PGE1↓, 1,   PGE2↓, 28,   PGE2↑, 1,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 3,   TLR4↓, 15,   TNF-α↓, 89,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 2,   Ach↑, 3,   AChE↓, 20,   AChE↑, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 7,   BDNF∅, 2,   BrainVol↑, 1,   ChAT↑, 4,   GABA↑, 1,   MAOA↓, 3,   MAOB↓, 2,   NGF↑, 2,   PSD95↑, 1,   SNAP25↑, 1,   TPH1↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 3,   Aβ↓, 26,   BACE/β-secretase↓, 10,   tau↓, 5,   p‑tau↓, 5,   XO↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1,   GR↑, 1,   PPARα↑, 3,   PPARγ↓, 1,   PPARγ↑, 6,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 22,   BioAv↑, 24,   BioAv↝, 10,   BioEnh↑, 3,   ChemoSen↑, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP2E1↓, 1,   Dose↑, 2,   Dose↝, 14,   eff↓, 1,   eff↑, 12,   eff↝, 1,   GSTP1/GSTπ↑, 1,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 7,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 11,   ALB↑, 1,   AST↓, 12,   BG↓, 1,   Bil↑, 2,   BMD↑, 1,   BP↓, 4,   colonLen↑, 1,   creat↓, 3,   CRP↓, 3,   EGFR↓, 1,   IL6↓, 70,   IL6↑, 2,   LDH↓, 6,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll?, 1,   antiAll↑, 4,   AntiArt↑, 2,   AntiCan↑, 7,   antiCG↑, 1,   AntiDiabetic↑, 4,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP↑, 24,   chemoP↑, 4,   chemoPv↑, 1,   cognitive↑, 32,   cognitive↝, 1,   hepatoP↓, 2,   hepatoP↑, 25,   Learn↑, 2,   memory↑, 33,   motorD↑, 4,   neuroP↑, 73,   NP/CIPN↓, 1,   Obesity↓, 4,   Pain↓, 8,   radioP↑, 6,   RenoP↑, 12,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 6,   toxicity↓, 10,   toxicity↑, 1,   toxicity↝, 4,   toxicity∅, 2,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiViral↑, 2,   Bacteria↓, 7,   Diar↓, 2,   GutMicro↑, 14,   Inf↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 446

Scientific Paper Hit Count for: iNOS, Inducible nitric oxide synthase
11 Silymarin (Milk Thistle) silibinin
9 Quercetin
7 Curcumin
7 Thymoquinone
6 Magnetic Fields
5 Baicalein
5 Propolis -bee glue
4 Alpha-Lipoic-Acid
4 Beta-Caryophyllene
4 Ferulic acid
4 isoorientin
4 Luteolin
4 Lycopene
4 Resveratrol
4 Sulforaphane (mainly Broccoli)
3 α-Bisabolol / Chamomile oil
3 Cichoric acid / Chicoric acid
3 Fisetin
3 Licorice
3 Pterostilbene
3 Rutin
2 Silver-NanoParticles
2 Allicin (mainly Garlic)
2 Artemisinin
2 Benzyl isothiocyanate
2 Phenethyl isothiocyanate
2 Boron
2 buckwheat sprouts
2 Caffeic acid
2 Carnosic acid
2 Capsaicin
2 Chrysin
2 Echinacea
2 Crocetin
2 EGCG (Epigallocatechin Gallate)
2 Eugenol
2 Gambogic Acid
2 Ginkgo biloba
2 Ginger/6-Shogaol/Gingerol
2 Isovitexin
2 Kaempferol
2 Magnolol
2 Melatonin
2 Mung Bean Sprouts
2 Rosmarinic acid
2 Shikonin
2 Aflavin-3,3′-digallate
2 Vitamin K2
1 Anthocyanins
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Apigenin (mainly Parsley)
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Cisplatin
1 Biochanin A
1 xanthohumol
1 Allyl isothiocyanate
1 Bromelain
1 Boswellia (frankincense)
1 Beetroot
1 Black Rice, Oryza sativa
1 Bruteridin(bergamot juice)
1 Carvacrol
1 Celastrol
1 Chlorogenic acid
1 Chocolate
1 Lecithin
1 Dichloroacetate
1 Diindolylmethane
1 Indole-3-carbinol
1 D-limonene
1 Dandelion Root
1 Ellagic acid
1 Emodin
1 Formononetin
1 Gamma-aminobutyric acid
1 Garcinol
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgetin
1 Grapeseed extract
1 Siegesbeckia glabrescens
1 Hops (Humulus lupulus)
1 Hyperoside
1 Vitexin
1 Licochalcone A
1 Lutein
1 MBE, Maqui berry
1 Magnetic Field Rotating
1 Moringin
1 Moringa oleifera
1 Morin
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Oleocanthal
1 Marjoram (Origanum majorana)
1 Oregano
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Protocatechuic acid
1 Piperine
1 Piperlongumine
1 Sinapic acid
1 acetaminophen
1 Taurine
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:159  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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