Iron Cancer Research Results

Iron, Iron: Click to Expand ⟱
Source:
Type:
Iron is an essential nutrient that is crucial for various cellular processes, including DNA synthesis, cell proliferation, and oxygen transport.
Cancer cells often have increased iron requirements due to their rapid growth and proliferation. Some tumors can acquire iron through various mechanisms, including upregulating iron transport proteins. This can support their growth and survival.
Excess iron can lead to the production of reactive oxygen species (ROS) through Fenton reactions, which can cause oxidative damage to DNA, proteins, and lipids. This oxidative stress can contribute to cancer development and progression.
Scientific Papers found: Click to Expand⟱
5088- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, BC, MCF7 - in-vitro, GBM, U87MG - in-vitro, Pca, PC3 - in-vitro, Cerv, HeLa - in-vitro, GBM, A172
Ferroptosis↑, ROS↑, Iron↑, xCT/SLC7A11↓, GSH↓, GPx4↓, lipid-P↑, TumCP↓, selectivity↑,
4723- SSE,    Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4
- in-vitro, CRC, HCT116
TumCP↓, Iron↑, MDA↑, ROS↑, MMP↓, NRF2↓, GPx4↓, Ferroptosis↑,
5333- TFdiG,    Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts
- vitro+vivo, OS, MG63
tumCV↓, TumCP↓, TumCCA↑, Iron↑, ROS↑, GSH↓, Fenton↑, Ferroptosis↑, Apoptosis↑, MAPK↑, ERK↑, JNK↑, p38↑, TumCG↓, Dose↝, FTH1↓, GPx4↓,
1216- VitC,    Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer
- in-vitro, Laryn, FaDu - in-vitro, SCC, SCC-154
Iron↝, ROS↑, tumCV↓, Ki-67↓, TumCCA↑, Ferroptosis↑, GSH↓, ROS↑, MDA↑, STAT3↓, GPx4↓, p‑STAT3↓,

Showing Research Papers: 101 to 104 of 104
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 104

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 2,   Fenton↑, 11,   GPx↓, 3,   GPx4↓, 46,   GPx4↑, 1,   GSH↓, 32,   GSH↑, 1,   GSH↝, 1,   i-GSH↓, 1,   GSH/GSSG↓, 4,   GSR↓, 1,   H2O2↑, 3,   HO-1↓, 4,   HO-1↑, 9,   Iron↓, 9,   Iron↑, 56,   Iron↝, 4,   Iron∅, 1,   i-Iron↓, 2,   i-Iron↑, 11,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↑, 34,   MDA↑, 25,   i-MDA↑, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NOX4↑, 1,   NRF2↓, 14,   NRF2↑, 8,   RNS↑, 1,   ROS↓, 6,   ROS↑, 72,   SOD↓, 4,   T-SOD↓, 1,   xCT/SLC7A11↓, 10,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 5,   Ferritin↑, 1,   FPN↝, 1,   FTH1↓, 4,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 1,   IronCh∅, 1,   LIP↑, 1,   Mets↑, 1,   NCOA4↑, 3,   NCOA4↝, 1,   SFXN2↓, 1,   Tf↓, 1,   Tf↑, 1,   TfR1/CD71↓, 2,   TfR1/CD71↑, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   mtDam↑, 8,   OXPHOS↓, 3,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 3,   ALDOA↓, 1,   AMPK↑, 6,   p‑AMPK↑, 1,   ATP↓, 4,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 6,   GSK‐3β↓, 1,   HK2↓, 2,   lactateProd↓, 4,   lactateProd↑, 1,   LDHA↓, 3,   MCT4↓, 1,   PDK1 / PDPK1↓, 1,   PFKP↓, 1,   PKM2↓, 2,   PKM2↑, 1,   Pyruv↓, 1,   SCD1↓, 1,   SLC1A5↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Apoptosis↑, 22,   BAX↑, 6,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   BIM↑, 1,   Casp↑, 2,   Casp3↑, 3,   cl‑Casp3↑, 2,   Casp8↑, 2,   Casp9↑, 1,   Cyt‑c↑, 4,   DR5↑, 3,   Fas↑, 1,   Ferroptosis↓, 2,   Ferroptosis↑, 61,   GranB/GZMB↝, 1,   MOMP↑, 1,   necrosis↑, 1,   p38↑, 3,   Perforin↝, 1,   Pyro↑, 2,   TumCD↑, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 13,   p‑Akt↓, 1,   CaMKII ↓, 1,   cMET↓, 1,   ERK↓, 1,   ERK↑, 2,   p‑ERK↑, 1,   IκB↑, 1,   JAK↓, 2,   JAK2↓, 1,   JNK↑, 4,   p‑JNK↑, 1,   MAPK↓, 2,   MAPK↑, 2,   p‑MAPK↑, 1,   MARK4↓, 1,   mTOR↓, 11,   mTOR↑, 2,   p‑mTOR↓, 1,   p‑p70S6↓, 1,   P70S6K↑, 1,   PI3K↓, 6,   p‑PI3K↑, 1,   p‑PI3k/Akt/mTOR↓, 1,   PTEN↑, 1,   RET↓, 1,   STAT3↓, 7,   STAT3↑, 1,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   ATFs↑, 1,   cMyc↓, 1,   DLEU1↓, 1,   DNMTs↓, 1,   HDAC↓, 1,   HDAC2↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-155↓, 1,   miR-182-5p↓, 1,   miR-592↑, 1,   OCT4↓, 1,   other↓, 2,   other↝, 2,   SOX2↓, 2,   SOX4↓, 2,   tumCV↓, 7,   tumCV↑, 1,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 5,   eIF2α↓, 1,   ER Stress↑, 7,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   autolysosome↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 1,   LC3II↑, 1,   LC3s↑, 1,   p62↓, 2,   p62↑, 1,   p‑p62↑, 1,   TumAuto↑, 11,   mt-TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   P53↓, 1,   P53↑, 7,   PARP↑, 1,   cl‑PARP↑, 1,   cl‑PARP↝, 1,   SIRT6↓, 1,   Telomerase↓, 1,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK2↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 3,   mitA↑, 1,   P21↓, 1,   P21↑, 2,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 1,   p‑pRB↓, 1,   TumCCA↑, 17,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   CD133↓, 1,   CSCs↓, 6,   CSCsMark↓, 1,   Diff↑, 1,   FOSL1↑, 1,   GDF15↓, 1,   Gli1↓, 1,   IGF-1↓, 1,   Ki-67↓, 3,   Nanog↓, 3,   NOTCH1↓, 2,   Piezo1↑, 2,   TumCG↓, 18,   TumCP↓, 27,   Wnt↓, 7,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   ATPase↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 2,   E-cadherin↑, 2,   EMT↓, 5,   MMP2↓, 3,   MMP9↓, 5,   MMPs↓, 1,   MUC1-C↓, 1,   N-cadherin↓, 2,   Sharpin↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β1↓, 1,   THBS1↓, 1,   TIMP2↓, 1,   TumCI↓, 6,   TumCMig↓, 7,   TumMeta↓, 3,   uPA↓, 1,   Vim↓, 3,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   EGR1↓, 1,   Hif1a↓, 5,   Hif1a↑, 1,   NO↓, 1,   REL↑, 1,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,   EPR↑, 1,   GLUT1↓, 3,   GLUT4↓, 1,   MMP↓, 12,   MPT↑, 1,   SLC12A5↓, 1,   TRPV1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   CD8+↑, 1,   COX2/PTGS2↓, 1,   CXCR4↓, 1,   DR4↑, 1,   HMGB1↓, 1,   IL12↑, 1,   IL2↑, 1,   Imm↑, 5,   Imm↝, 1,   Inflam↓, 2,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   MCT1↓, 1,   NF-kB↓, 5,   NF-kB↑, 1,   NK cell↑, 1,   PD-L1↓, 2,   SOCS-3↑, 1,   TLR1↑, 1,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↝, 1,   i-pH↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 22,   Dose?, 1,   Dose↝, 4,   eff↓, 12,   eff↑, 11,   eff↝, 2,   Half-Life↓, 1,   MDR1↓, 3,   P-gp/ABCB1↓, 2,   RadioS↑, 3,   selectivity↑, 11,   Synergy↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

AR↝, 1,   BMD↑, 1,   E6↓, 1,   E7↓, 1,   Ferritin↓, 5,   Ferritin↑, 1,   LDH↓, 1,   PD-L1↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 11,   antiCG↓, 1,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 2,   chemoP↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 1,   QoL↑, 2,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 5,   TumW↓, 5,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 1,  
Total Targets: 337

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 8,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 3,   Copper↓, 2,   Fenton↓, 2,   GPx↓, 1,   GPx↑, 7,   GPx4↓, 2,   GPx4↑, 4,   GSH↓, 2,   GSH↑, 6,   GSR↑, 1,   HDL↓, 1,   HO-1↓, 2,   HO-1↑, 2,   HO-1↝, 1,   Iron↓, 15,   Iron↑, 2,   Iron↝, 2,   Iron∅, 1,   i-Iron↓, 3,   i-Iron↑, 1,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↓, 7,   MDA↑, 2,   NOX↓, 1,   NRF2↓, 2,   NRF2↑, 9,   ROS↓, 21,   ROS↑, 2,   i-ROS↑, 1,   SOD↓, 2,   SOD↑, 7,   TAC↑, 1,   TBARS↓, 1,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   FTH1↓, 1,   FTL↓, 1,   IronCh↑, 4,   NCOA4↝, 1,   TfR1/CD71↓, 2,   TfR1/CD71↑, 1,   Zn2+↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 3,   ALAT↑, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 7,   BAX↓, 2,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↓, 3,   Casp3↑, 1,   Ferroptosis↓, 7,   Ferroptosis↑, 1,   iNOS↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   CREB↑, 1,   ERK↓, 1,   ERK↑, 1,   JNK↓, 2,   MAPK↓, 1,   PKA↑, 1,   PKCδ?, 1,   PTEN↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 2,   other↑, 3,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   GRP78/BiP↓, 1,   IRE1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,   Zn2+↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   Ca+2↝, 1,   MMP9↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   BBB↝, 1,   BBB∅, 2,   CLDN4↑, 1,   MMP↑, 1,   OCLN↑, 1,   TJ↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   HMGB1↓, 1,   IL17↓, 1,   IL1β↓, 3,   IL6↓, 4,   Inflam↓, 10,   NeuroI↓, 1,   NF-kB↓, 1,   NLRP3↓, 1,   RAGE↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   ADAM10↑, 1,   BDNF↑, 2,   PSD95↑, 3,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   Aβ42↓, 2,   BACE/β-secretase↝, 1,   tau↓, 1,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 2,   ChemoSen↑, 1,   Dose?, 2,   Dose↝, 1,   eff↑, 4,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↑, 1,   anemia↓, 1,   AST↑, 1,   Bil↓, 1,   BUN↓, 1,   creat↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   IL6↓, 4,   IRes↓, 1,   LDH↑, 1,   RAGE↓, 1,   RBC↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   cardioP↑, 2,   cardioP∅, 1,   CardioT↓, 1,   chemoP↑, 2,   cognitive↑, 4,   hepatoP↓, 2,   hepatoP↑, 1,   Learn↑, 1,   memory↑, 1,   motorD↑, 1,   neuroP↑, 7,   OS↑, 1,   RenoP↑, 2,   Stroke↓, 3,   toxicity↓, 5,   toxicity↝, 2,   toxicity∅, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 161

Scientific Paper Hit Count for: Iron, Iron
9 Artemisinin
6 Lactoferrin/Talactoferrin
6 Shikonin
5 Curcumin
5 Cisplatin
5 Matrine
4 Vitamin C (Ascorbic Acid)
4 Luteolin
4 salinomycin
4 Selenite (Sodium)
3 doxorubicin
3 phytic acid, Inositol hexakisphosphate
3 Isoliquiritigenin
3 Magnetic Fields
2 Disulfiram
2 Copper and Cu NanoParticles
2 ferumoxytol
2 Huperzine A/Huperzia serrata
2 Kaempferol
2 Licochalcone A
2 Mung Bean Sprouts
2 Myricetin
2 Quercetin
2 Rosmarinic acid
2 Sulforaphane (mainly Broccoli)
1 Astragalus
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Andrographis
1 Ashwagandha(Withaferin A)
1 Boswellia (frankincense)
1 brusatol
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Carvacrol
1 Choline
1 Citric Acid
1 diet FMD Fasting Mimicking Diet
1 Diindolylmethane
1 EGCG (Epigallocatechin Gallate)
1 Fucoidan
1 Gallic acid
1 Ginkgo biloba
1 Ginkgetin
1 HydroxyCitric Acid
1 Honokiol
1 HydroxyTyrosol
1 Hyperoside
1 Isobavachalcone
1 isoorientin
1 Juglone
1 Metformin
1 Magnetic Field Rotating
1 Melatonin
1 magnetic nanoparticles
1 immunotherapy
1 Morin
1 Phenethyl isothiocyanate
1 Sulfasalazine
1 Spermidine
1 erastin
1 Aflavin-3,3′-digallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:160  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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