JNK Cancer Research Results

JNK, c-Jun N-terminal kinase (JNK): Click to Expand ⟱
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Type:
JNK acts synergistically with NF-κB, JAK/STAT, and other signaling molecules to exert a survival function. Janus signaling promotes cancer cell survival.
JNK, or c-Jun N-terminal kinase, is a member of the mitogen-activated protein kinase (MAPK) family. It plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis (programmed cell death). JNK is activated in response to various stress signals, such as UV radiation, oxidative stress, and inflammatory cytokines.
JNK activation can promote apoptosis in cancer cells, acting as a tumor suppressor. However, in other contexts, it can promote cell survival and proliferation, contributing to tumor progression.

JNK is often unregulated in cancers, leading to increased cancer cell proliferation, survival, and resistance to apoptosis. This activation is typically associated with poor prognosis and aggressive tumor behavior.
Scientific Papers found: Click to Expand⟱
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
6865- FA,    Ferulic Acid Regulates GSDMD through the ROS/JNK/Bax Mitochondrial Apoptosis Pathway to Induce Pyroptosis in Lung Cancer
- in-vitro, Lung, NA
TumCP↓, MMP↓, LDH↑, Pyro↑, GSDMD↑, ROS↑, JNK↑, BAX↑,
2844- FIS,    Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells
- in-vitro, OS, U2OS
tumCV↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, BAD↑, Bcl-2↓, Bcl-xL↓, PI3K↓, Akt↓, ERK↓, p‑JNK↑, p‑cJun↑, p‑p38↑, ROS↑, MMP↓, mTORC1↓, PTEN↑, p‑GSK‐3β↓, GSK‐3β↑, NF-kB↓, IKKα↑, Cyt‑c↑,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2830- FIS,    Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
- Review, Var, NA
TumCG↓, angioG↓, *ROS↓, TumCMig↓, VEGF↓, MAPK↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, NRF2↑, HO-1↑, ROS↓, Inflam↓, ER Stress↑, ROS↑, TumCP↓, ChemoSen↑, PTEN↑, P53↑, Casp3↑, Casp8↑, Casp9↑, COX2/PTGS2↓, Wnt↓, EGFR↓, Mcl-1↓, survivin↓, IAP1↓, IAP2/BIRC3↓, PGE2↓, β-catenin/ZEB1↓, DR5↑, MMP2↓, MMP9↓, FAK↓, uPA↓, EMT↓, ERK↓, JNK↑, p38↑, PKCδ↓, BioAv↓, BioAv↑, BioAv↑,
5392- FIS,  AsP,    Fisetin topical delivery via ascorbyl palmitate/hyaluronan-enhanced limosomes: a novel paradigm for preventing UVB-induced skin photoaging
- in-vivo, Nor, NA
eff↑, *antiOx↑, *MMP9↓, *TNF-α↓, *NF-kB↓, *SOD↑, *Catalase↑, *AntiAge↑, *Inflam↓, *JNK↓,
6917- FIS,    Dietary flavonoid fisetin regulates aluminium chloride-induced neuronal apoptosis in cortex and hippocampus of mice brain
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, *Dose↝, *Aβ↓, *ASK1↓, *p‑JNK↓, *P53↓, *Cyt‑c↓, *Casp9↓, *Bax:Bcl2↝,
6901- FIS,    Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
- in-vivo, HNSCC, CAL33
TumCG↓, TumCD↑, selectivity↑, TumCCA↑, CDC25↓, CDK1↓, CycB/CCNB1↓, P53↑, DNAdam↑, Apoptosis↑, γH2AX↑, cl‑PARP↑, other↝, JNK↑, PI3K↓, Akt↓, ERK↓, EGFR↓, STAT3↓, TumAuto↑, Dose↝, TumVol↓, Ki-67↓, cl‑Casp3↑, P21↓, p27/CDKN1B↓,
7059- GamB,    Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells
- in-vitro, CRC, HCT15
TumCP↓, Apoptosis↑, JNK↑, TumCCA↑, cycD1/CCND1↓, P53↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, MMP↓, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓,
2060- GamB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA
TumCP↓, TumAuto↑, eff↑, ROS↑, ER Stress↑, JNK↑,
1958- GamB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA - in-vivo, NA, NA
AntiCan↑, TumCP↓, TumAuto↑, eff↑, JNK↑, ROS↑, ER Stress↑, eff↓, TumCG↓,
1971- GamB,    Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
- in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, MDA-MB-468 - in-vivo, NA, NA
Paraptosis↑, ER Stress↑, MMP↓, eff↓, selectivity↑, p‑ERK↑, p‑JNK↑, eff↓,
7087- GAR,    Garcinol as an Epigenetic Modulator: Mechanisms of Anti-Cancer Activity and Therapeutic Potential
- Review, Var, NA
HATs↓, p300↓, CBP↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, Inflam↓, angioG↓, TumCP↓, TumMeta↓, TumCCA↑, EMT↓, CSCs↓, P53↑, TrxR↓, ROS↑, JNK↑, DNAdam↑, mt-Apoptosis↑, ER Stress↑, CHOP/DDIT3↑, DDIT4↑, TRIB3↑, SESN2↑, miR-218↑, eff↑, ChemoSen↑, BioAv↓, Half-Life↓, BioAv↑,
7207- GBE,    The molecular mechanisms of ginkgo (Ginkgo biloba) activity in signaling pathways: A comprehensive review
- Review, AD, NA
*Inflam↓, *Apoptosis↓, *neuroP↑, *cardioP↑, *hepatoP↑, *AntiViral↑, *Bacteria↓, *RenoP↑, *ROS↓, *NADPH↓, *MAPK↓, *ERK↓, *JNK↓, *AP-1↓, *cAMP↑, *STAT5↓, *AMPK↑,
7103- GEN,    A Comprehensive Review of Genistein's Effects in Preclinical Models of Cervical Cancer
- Review, Cerv, NA
TumCP↓, Apoptosis↑, RadioS↑, ChemoSen↑, *antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, TumCG↓, TumCI↓, TumCCA↑, cl‑PARP↑, selectivity↑, CycB/CCNB1↓, CDK1↓, p‑cDC2↓, p‑ERK↓, p‑p38↑, p‑JNK↑, MMP9↓, TIMP1↑, BioAv↓, BioAv↑, Half-Life↑,
7279- GGB,  Rad,    Radioprotective effect of Ginkgolide B on brain: the mediating role of DCC/MST1 signaling
- in-vivo, Nor, NA
*cognitive↑, *radioP↑, *ROS↓, *p‑Akt↑, *Bcl-2↑, *Mst1↓, *p‑p38↓, *JNK↓, *cl‑Casp3↓, *BAX↓,
7138- GI,    6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, Liver, HepG2 - in-vitro, Lung, A549
TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2/PTGS2↓, IAP1↓, Dose?,
1005- GI,    Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
- vitro+vivo, Nor, HUVECs
*NF-kB↓, *p65↓, *TLR4∅, *angioG↓, *TumCP↓, *VEGF↓, *Inflam↓, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *p‑JNK↓, *HO-1↑,
7247- Gink,    Ginkgetin inhibits growth of breast carcinoma via regulating MAPKs pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT474 - vitro+vivo, BC, MCF7
TumCP↓, Apoptosis↑, TumCG↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, survivin↓, p‑ERK↑, cl‑JNK↑,
845- Gra,    A Review on Annona muricata and Its Anticancer Activity
- Review, NA, NA
GlucoseCon↓, ATP↓, HIF-1↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ERK↓, Akt↓, Apoptosis↑, NF-kB↓, ROS↑, Bax:Bcl2↑, MMP↓, Casp3↑, Casp9↑, p‑JNK↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, eff↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑,
3774- H2,    The role of hydrogen in Alzheimer’s disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *memory↑, *Aβ↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *p‑p38↓, *JNK↓, *ROS↓, *cognitive↑, *ER(estro)↑, *BDNF↑,
3766- H2,    The role of hydrogen in Alzheimer′s disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *AMPK↑, *SIRT1↑, *FOXO↑, *mtDam↓, *neuroP↑, *ROS↓, *p38↓, *cognitive↑, *BDNF↑, *memory↑, *lipid-P↓, *IL6↓, *TNF-α↓, *JNK↓, *NF-kB↓, *NLRP3↓,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
7363- HibSad,    Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation
Apoptosis↑, selectivity↑, p‑p38↑, JNK↑, cJun↑, Cyt‑c↑, Fas↑, FasL↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
601- HT,    Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells
- in-vivo, NA, HT-29
TumCG↓, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, JNK↑, TNF-α↓, PPP2R1A↑,
7554- HYP,    Effect of hyperoside on the apoptosis of A549 human non‑small cell lung cancer cells and the underlying mechanism
- in-vitro, NSCLC, A549
tumCV↓, Apoptosis↑, p‑MAPK↑, JNK↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, AIF↑,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7761- ISL,    Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, ROS↑, JNK↑, p38↑, STAT3↑, NF-kB↓, IκB↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, P21↑, p27/CDKN1B↑, CycB/CCNB1↑, CDK1↓, CDK2↓, GRP78/BiP↓, PI3K↓, Akt↓, mTOR↓, eff↑, GLUT4↓, lactateProd↓, OXPHOS↓, Glycolysis↓, BioAv↑, ENO1↓, ALDOA↓, LDHA↓, MCT4↓, RadioS↑, Ferroptosis↑, i-Iron↑, BioAv↑, Half-Life↓,
7856- isoO,    Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways
- in-vitro, Lung, A549
Bacteria↓, Inflam↓, TumCD↑, selectivity↑, Apoptosis↑, MMP↓, BAX↑, cl‑Casp3↑, PARP↓, Bcl-2↓, TumCCA↑, CycB/CCNB1↓, CDK1↓, CDK2↓, NA↑, p27/CDKN1B↑, ROS↑, eff↓, p‑p38↑, p‑JNK↑, ERK↓, STAT3↓, NF-kB↓,
7876- isoO,    Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway
- in-vitro, Nor, NA
*neuroP↑, *ROS↓, *MMP↑, *GCLC↑, *GCLM↑, *HO-1↑, *NQO1↑, *Trx1↑, *NRF2↑, *Keap1↓, *p‑AMPK↑, *p‑ERK↑, *p‑GSK‐3β↑, *p‑JNK↑, *p‑PI3K↑, *p‑Akt↑, *AMPK↑, *Akt↑,
7873- isoO,    Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways
- in-vitro, Liver, HepG2 - in-vitro, CRC, HT-29 - in-vitro, Lung, A549
ChemoSen↑, TumCP↓, chemoP↑, *ROS↓, *mtDam↓, *Apoptosis↓, *cardioP↑, *NRF2↑, *TGF-β↑, *p‑JNK↓, *p‑p38↓, *MAPK↝, *Akt↝, *STAT3↝,
5118- JG,    Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells
- in-vitro, HCC, HepG2
m-ROS↑, DNAdam↑, Apoptosis↑, TumAuto↑, p38↑, MAPK↑, JNK↑, MMP↓, LC3II↑, Beclin-1↑,
2923- LT,    Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells
- in-vitro, NA, NA
Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2911- LT,    Luteolin targets MKK4 to attenuate particulate matter-induced MMP-1 and inflammation in human keratinocytes
- in-vitro, Nor, HaCaT
*MMP1↓, *COX2/PTGS2↓, *IL6↓, *AP-1↓, *NF-kB↓, *ROS↓, *p‑MKK4↑, *p‑JNK↓, *p‑p38↓,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
3278- Lyco,    Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells
- in-vitro, Colon, SW480
TNF-α↓, IL1β↓, IL6↓, iNOS↓, COX2/PTGS2↓, PGE2↓, NO↓, NF-kB↓, JNK↓, Inflam↓, MPO↓,
4228- Lyco,    A review for the pharmacological effect of lycopene in central nervous system disorders
- Review, AD, NA - Review, Park, NA
*cognitive↑, *memory↑, *Inflam↓, *Apoptosis↓, *ROS↓, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *MDA↓, *GPx↑,
4780- Lyco,    Potential inhibitory effect of lycopene on prostate cancer
- Review, Pca, NA
TumCP↓, TumCCA↑, Apoptosis↑, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *Ca+2↝, *antiOx↑, *AntiCan↑, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *TNF-α↓, NF-kB↓, DNAdam↓, PSA↓, P53↓, cycD1/CCND1↓, NRF2↓, Akt2↓, PPARγ↓,
1089- MAG,    Magnolol potently suppressed lipopolysaccharide-induced iNOS and COX-2 expression via downregulating MAPK and NF-κB signaling pathways
- in-vitro, AML, RAW264.7
p‑IκB↓, NF-kB↓, p‑ERK↓, p‑JNK↓, p‑PI3K↓, p‑Akt↓, iNOS↓, COX2/PTGS2↓,
4519- MAG,    Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiAg↑, *BBB↑, *BioAv↓, BAD↑, Casp3↑, Casp6↑, Casp9↑, JNK↑, Bcl-xL↓, PTEN↑, Akt↓, NF-kB↓, MMP7↓, MMP9↓, uPA↓, Hif1a↓, VEGF↓, FOXO3↓, Ca+2↑, TumCCA↑, ROS↑, Cyt‑c↑,
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
486- MF,    mTOR Activation by PI3K/Akt and ERK Signaling in Short ELF-EMF Exposed Human Keratinocytes
- in-vitro, Nor, HaCaT
*mTOR↑, *PI3K↑, *Akt↑, *p‑ERK↑, *other↑, *p‑JNK↑, *p‑P70S6K↑,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, eff↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
218- MFrot,  MF,    Extremely low frequency magnetic fields inhibit adipogenesis of human mesenchymal stem cells
- in-vitro, Nor, NA
*PPARγ↓, *p‑JNK↑, *Wnt↑, *ALP∅, *COL1∅, *RUNX2∅, *OCN∅, *FABP4↓, *p‑JNK↑, *Diff↓,
204- MFrot,  MF,    Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
- in-vivo, AD, NA
*NF-kB↓, *MAPK↓, *TLR4↓, *memory↑, *cognitive↑, *TGF-β1↑, *ARG1/2↑, *IL4↑, *IL10↑, *IL6↓, *IL1↓, *TNF-α↓, *iNOS↓, *ROS↓, *NO↓, *MyD88↓, *p‑IKKα↓, *p‑IκB↓, *p‑p65↓, *p‑JNK↓, *p‑p38↓, *ERK↓, *neuroP↑, *Aβ↓,
1271- NCL,    Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics
- vitro+vivo, Ovarian, SKOV3
Wnt/(β-catenin)↓, mTOR↓, STAT3↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, MEK↓, ERK↓, mitResp↓, Glycolysis↓, ROS↑, JNK↑,

Showing Research Papers: 101 to 150 of 203
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 203

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CD47↓, 1,   DDIT4↑, 1,   miR-124-3p↓, 1,   NA↑, 1,   PFS↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx⇅, 1,   Catalase↓, 1,   CYP1A1↓, 2,   Ferroptosis↑, 1,   GPx↓, 1,   GSH↓, 2,   GSR↓, 1,   GSTs↓, 1,   H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 1,   i-Iron↑, 1,   MPO↓, 1,   NQO1↓, 1,   NRF2↓, 3,   NRF2↑, 3,   OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 18,   m-ROS↑, 1,   SIRT3↑, 2,   SOD↓, 1,   SOD2↓, 1,   TrxR↓, 1,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 1,   CDC2↓, 1,   CDC25↓, 1,   MEK↓, 1,   mitResp↓, 1,   MMP↓, 11,   PGC-1α↑, 1,   c-Raf↓, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALDOA↓, 1,   AMPK↑, 2,   ATG7↑, 1,   CAIX↑, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   ENO1↓, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 1,   LDH↑, 1,   LDHA↓, 2,   MCT4↓, 1,   PPARγ↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 14,   p‑Akt↓, 2,   Apoptosis↑, 20,   mt-Apoptosis↑, 1,   BAD↑, 2,   BAX↑, 9,   Bax:Bcl2↑, 1,   Bcl-2↓, 8,   Bcl-2↑, 1,   Bcl-xL↓, 5,   Casp↑, 2,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 13,   cl‑Casp3↑, 5,   Casp6↑, 1,   Casp8↑, 6,   cl‑Casp8↑, 2,   Casp9↑, 12,   cl‑Casp9↑, 2,   CBP↓, 1,   Cyt‑c↑, 9,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 6,   Fas↑, 4,   FasL↑, 3,   Ferroptosis↑, 1,   GSDMD↑, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 2,   iNOS↓, 3,   JNK↓, 2,   JNK↑, 23,   p‑JNK↓, 2,   p‑JNK↑, 5,   cl‑JNK↑, 1,   MAPK↓, 4,   MAPK↑, 4,   p‑MAPK↑, 1,   Mcl-1↓, 2,   Mcl-1↑, 1,   MDM2↓, 1,   p‑MDM2↓, 1,   NICD↓, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 6,   p38↑, 7,   p‑p38↑, 5,   Paraptosis↑, 1,   PPP2R1A↑, 1,   Pyro↑, 1,   survivin↓, 6,   Telomerase↓, 1,   TumCD↑, 3,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   EF-1α↓, 1,   p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   cJun↑, 3,   p‑cJun↑, 1,   EZH2↓, 1,   H3↓, 1,   H3↑, 1,   H4↓, 1,   H4↑, 1,   HATs↓, 1,   HATs↑, 1,   miR-218↑, 1,   other↑, 1,   other↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑ATF6↑, 1,   CHOP/DDIT3↑, 4,   cl‑CHOP/DDIT3↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 12,   GRP78/BiP↓, 1,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSPs↑, 1,   IRE1↑, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1↑, 2,   LC3B-II↑, 1,   LC3II↑, 4,   SESN2↑, 1,   TumAuto↑, 8,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↓, 1,   DNAdam↑, 5,   DNArepair↑, 1,   P53↓, 1,   P53↑, 10,   PARP↓, 1,   PARP↑, 1,   cl‑PARP↑, 9,   PCNA↓, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK2↓, 7,   CDK4↓, 6,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 7,   cycE/CCNE↓, 2,   P21?, 1,   P21↓, 1,   P21↑, 6,   p‑RB1↓, 1,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CD34↓, 1,   p‑cDC2↓, 1,   cFos↓, 1,   cFos↑, 1,   CSCs↓, 2,   EMT↓, 6,   ERK↓, 8,   ERK↑, 2,   p‑ERK↓, 2,   p‑ERK↑, 2,   FOXO3↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   HDAC↓, 2,   IGF-1↓, 1,   IGF-1R↓, 1,   mTOR↓, 5,   mTORC1↓, 3,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 3,   NOTCH3↓, 1,   OCT4↓, 1,   p300↓, 1,   PI3K↓, 12,   p‑PI3K↓, 2,   PTEN↓, 1,   PTEN↑, 4,   RAS↓, 1,   SOX2↓, 1,   p‑Src↓, 1,   STAT3↓, 8,   STAT3↑, 1,   p‑STAT3↓, 1,   p‑STAT6↓, 1,   TAZ↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 7,   TumCG↑, 1,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   Akt2↓, 1,   AXL↓, 1,   Ca+2↑, 4,   CCN2/CTGF↓, 1,   CD31/PECAM-1↓, 1,   Cdc42↓, 1,   CEA↓, 1,   CLDN1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 3,   ER-α36↓, 1,   FAK↓, 3,   ITGB1↓, 1,   Ki-67↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 7,   MMP7↓, 1,   MMP9↓, 10,   MMPs↓, 1,   N-cadherin↓, 3,   PDGF↓, 1,   PKCδ↓, 2,   Rac1↓, 1,   RAGE↓, 1,   Rho↓, 1,   Snail↓, 1,   SOX4↓, 1,   TIMP1↑, 2,   TIMP2↑, 2,   Treg lymp↓, 1,   TRIB3↑, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 15,   TumMeta↓, 5,   TumMeta↑, 1,   Twist↓, 1,   Tyro3↓, 1,   uPA↓, 4,   Vim↓, 2,   Vim↑, 1,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 3,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   ATF4↑, 1,   EGFR↓, 3,   EGFR↑, 1,   HIF-1↓, 1,   Hif1a↓, 5,   NO↓, 2,   NO↑, 1,   VEGF↓, 8,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 2,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   CD4+↑, 1,   COX2/PTGS2↓, 8,   CXCR4↓, 1,   FOXP3↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IKKα↓, 2,   IKKα↑, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 3,   IL8↓, 2,   Inflam↓, 4,   IκB↑, 1,   p‑IκB↓, 1,   JAK2↓, 1,   NF-kB↓, 20,   p‑NF-kB↑, 1,   NK cell↑, 2,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 1,   PGE2↓, 4,   PSA↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TNF-α↓, 2,   TNF-α↑, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 2,   CDK6↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 7,   BioAv↝, 1,   ChemoSen↓, 1,   ChemoSen↑, 12,   CYP1A2↓, 1,   Dose?, 1,   Dose↝, 5,   Dose∅, 1,   eff↓, 6,   eff↑, 15,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 2,   MDR1↓, 1,   P450↓, 1,   RadioS↑, 7,   selectivity↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   BRCA1↑, 1,   CEA↓, 1,   EGFR↓, 3,   EGFR↑, 1,   EZH2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 3,   Ki-67↓, 1,   LDH↑, 1,   NSE↓, 1,   PSA↓, 1,   RAGE↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   cachexia↓, 1,   chemoP↑, 4,   chemoPv↑, 1,   ChemoSideEff↓, 1,   NP/CIPN↓, 1,   OS↑, 2,   QoL↑, 1,   radioP↑, 2,   TumVol↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   CD8+↑, 2,  
Total Targets: 366

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

compII↑, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 10,   ARE↑, 1,   Bil↑, 1,   Catalase↑, 7,   Fenton↓, 1,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 4,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 3,   GSR↑, 1,   GSTA1↑, 1,   GSTs↑, 1,   HO-1↑, 5,   Keap1↓, 1,   lipid-P↓, 4,   MDA↓, 3,   MPO↓, 1,   NQO1↑, 2,   NRF2↑, 8,   ROS↓, 15,   SOD↑, 6,   SOD1↑, 1,   Trx1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   compIII↑, 1,   p‑MKK4↑, 1,   MMP↑, 2,   mtDam↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 4,   p‑AMPK↑, 1,   cAMP↑, 1,   p‑cMyc↑, 1,   FABP4↓, 1,   LDL↓, 1,   NADPH↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↑, 3,   Akt↝, 1,   p‑Akt↑, 2,   Apoptosis↓, 3,   ASK1↓, 1,   BAX↓, 1,   Bax:Bcl2↝, 1,   Bcl-2↑, 1,   Casp12↓, 1,   Casp3↓, 1,   cl‑Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 2,   JNK↓, 8,   p‑JNK↓, 6,   p‑JNK↑, 4,   MAPK↓, 2,   MAPK↝, 1,   p‑MAPK↓, 1,   p38↓, 3,   p‑p38↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

OCN∅, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↓, 1,   ERK↓, 2,   ERK↑, 1,   p‑ERK↑, 2,   FOXO↑, 1,   FOXO3↑, 1,   p‑GSK‐3β↑, 1,   Mst1↓, 1,   mTOR↓, 1,   mTOR↑, 1,   p‑P70S6K↑, 1,   PI3K↑, 2,   p‑PI3K↑, 1,   RUNX2∅, 1,   STAT3↝, 1,   STAT5↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 2,   APP↓, 1,   ARG1/2↑, 1,   Ca+2↓, 1,   Ca+2↝, 1,   COL1∅, 1,   E-sel↓, 1,   MMP1↓, 1,   MMP9↓, 1,   TGF-β↑, 2,   TGF-β1↑, 1,   TumCP↓, 1,   VCAM-1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   ATF4↓, 1,   NO↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   IBI↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 1,   p‑IKKα↓, 1,   IL1↓, 2,   IL10↑, 3,   IL1β↓, 3,   IL4↓, 1,   IL4↑, 1,   IL6↓, 6,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 14,   p‑IκB↓, 1,   LPS↓, 1,   MyD88↓, 1,   NF-kB↓, 8,   p65↓, 1,   p‑p65↓, 1,   PGE2↓, 1,   TLR4↓, 1,   TLR4∅, 1,   TNF-α↓, 7,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 5,   ChAT↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 5,   BACE/β-secretase↓, 1,   NLRP3↓, 4,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 1,   Dose↝, 4,   eff↑, 2,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP∅, 1,   AST↓, 1,   Bil↑, 1,   creat↓, 1,   GutMicro↑, 2,   IL6↓, 6,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   antiPs↑, 1,   cardioP↑, 3,   cognitive↑, 7,   hepatoP↑, 4,   memory↑, 5,   neuroP↑, 12,   Obesity↓, 1,   radioP↑, 2,   RenoP↑, 3,   toxicity?, 1,   toxicity↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 3,   Sepsis↓, 1,  
Total Targets: 176

Scientific Paper Hit Count for: JNK, c-Jun N-terminal kinase (JNK)
9 Berberine
9 Curcumin
7 Fisetin
7 Silymarin (Milk Thistle) silibinin
6 Apigenin (mainly Parsley)
6 Shikonin
6 Thymoquinone
5 Silver-NanoParticles
5 Allicin (mainly Garlic)
5 Capsaicin
5 Luteolin
5 Rosmarinic acid
4 Alpha-Lipoic-Acid
4 Baicalein
4 Chlorogenic acid
4 Chrysin
4 Copper and Cu NanoParticles
4 Disulfiram
4 Gambogic Acid
4 Magnetic Fields
4 Piperlongumine
3 Radiotherapy/Radiation
3 Artemisinin
3 Betulinic acid
3 Carvacrol
3 chaetocin
3 EGCG (Epigallocatechin Gallate)
3 Hydrogen Gas
3 isoorientin
3 Lycopene
3 Propolis -bee glue
3 Phenethyl isothiocyanate
3 Quercetin
2 Astragalus
2 Vitamin C (Ascorbic Acid)
2 Cisplatin
2 Ashwagandha(Withaferin A)
2 Beta-Caryophyllene
2 Boswellia (frankincense)
2 brusatol
2 Thymol-Thymus vulgaris
2 Celastrol
2 Ursolic acid
2 Ferulic acid
2 Ginger/6-Shogaol/Gingerol
2 Hibiscus sabdariffa
2 Magnolol
2 Magnetic Field Rotating
2 Phenylbutyrate
2 Plumbagin
2 Resveratrol
2 Vitamin K2
1 1,8-Cineole
1 Camptothecin
1 Anethole/trans-Anethole
1 Berbamine
1 Bromelain
1 Bruteridin(bergamot juice)
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 Crocetin
1 Cucurbitacin
1 Bicalutamide
1 Sulforaphane (mainly Broccoli)
1 Dihydrocaffeic Acid
1 Cynaropicrin
1 Dandelion Root
1 Emodin
1 Eugenol
1 5-fluorouracil
1 Evodiamine
1 Ascorbyl Palmitate
1 Garcinol
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Ginkgolide B
1 Ginkgetin
1 Graviola
1 Honokiol
1 HydroxyTyrosol
1 Hyperoside
1 Indole-3-carbinol
1 Isoliquiritigenin
1 Juglone
1 Melatonin
1 Niclosamide (Niclocide)
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Parthenolide
1 Pterostilbene
1 Kaempferol
1 Perilla
1 salinomycin
1 Gemcitabine (Gemzar)
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:168  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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