Mcl-1 Cancer Research Results

Mcl-1, myeloid cell leukemia 1: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
A member of the Bcl-2 family of proteins, which play a crucial role in regulating apoptosis, or programmed cell death. In cancer, Mcl-1 is often overexpressed, contributing to the development and progression of various types of tumors.
Mcl-1 is often overexpressed in several cancers, including hematological malignancies (like leukemia and lymphoma) and solid tumors (such as breast, lung, and prostate cancers).
Mcl-1 inhibits apoptosis by binding to pro-apoptotic proteins, preventing them from triggering the cell death pathway.


Scientific Papers found: Click to Expand⟱
2982- RES,    The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1
- in-vitro, Melanoma, MSTO-211H
tumCV↓, Apoptosis↑, Sp1/3/4↓, p27/CDKN1B↓, P21↓, cycD1/CCND1↓, Mcl-1↓, survivin↓,
7378- RS,    Reserpine inhibits DNA repair, cell proliferation, invasion and induces apoptosis in oral carcinogenesis via modulation of TGF-β signaling
- in-vitro, Oral, NA
*antiOx↑, *AntiBio↑, TGF-β↓, p‑SMAD3↓, p‑SMAD2↓, p‑SMAD4↓, SMAD3↓, Snail↓, ERCC1↓, ERCC4/XPF↓, Ku70/XRCC6↓, PCNA↓, cycD1/CCND1↓, Hif1a↓, IL6↓, Mcl-1↓, BAX↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, PARP↑, DNArepair↓, TumCP↓, TumCI↓,
1469- SFN,    Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, Pca, NA
Synergy↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, Synergy↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, Synergy↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
3043- SK,    Shikonin Induces Apoptosis by Inhibiting Phosphorylation of IGF-1 Receptor in Myeloma Cells.
- in-vitro, Melanoma, RPMI-8226
IGF-1↓, Apoptosis↑, TumCCA↑, MMP↓, Casp3↑, P53↑, BAX↑, Mcl-1↓, EGFR↓, Src↑, VEGFR2/KDR/Flk1↓, p‑IGF-1↓, PI3K↓, Akt↓,
5332- TFdiG,    Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2/BIRC3↑, XIAP↓, TNF-α↓, COX2/PTGS2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, CompStab↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,

Showing Research Papers: 101 to 110 of 110
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 110

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   frataxin↑, 1,   GSH↓, 5,   GSR↑, 1,   GSTs↓, 1,   HO-1↓, 3,   HO-1↑, 4,   HO-2↓, 1,   Keap1↓, 1,   lipid-P↓, 2,   lipid-P↑, 5,   NQO1↑, 1,   NRF2↓, 4,   NRF2↑, 5,   PAO↑, 1,   Prx6↑, 1,   ROS↓, 3,   ROS↑, 51,   ROS⇅, 3,   i-ROS↓, 1,   SOD↓, 2,   Trx↓, 1,   ox-Trx1↑, 1,   TrxR↓, 1,   TrxR1↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 4,   CDC25↓, 2,   EGF↓, 1,   MCU↓, 1,   mitResp↓, 2,   mtDam↑, 3,   OCR↓, 1,   OXPHOS↓, 2,   mt-OXPHOS↓, 2,   PDH↓, 3,   PDH↑, 1,   PINK1↑, 1,   SDH↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   12LOX↓, 2,   5LO↓, 1,   ACC↑, 3,   ACLY↓, 2,   ALAT↓, 2,   AMACR↓, 1,   AMPK?, 1,   AMPK↑, 7,   ATP↓, 6,   citrate↓, 1,   CPT1A↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FASN↑, 2,   FBPase↑, 2,   GAPDH↓, 2,   GLO-I↓, 1,   glucoNG↑, 2,   GlucoseCon↓, 4,   GlutaM↓, 1,   Glycolysis↓, 8,   GSK‐3β↓, 3,   GSK‐3β↑, 3,   HK2↓, 5,   lactateProd↓, 2,   LDHA↓, 3,   LDL↓, 1,   NADPH↓, 1,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PFK↓, 1,   PFK1↓, 2,   PFK2?, 1,   PFK2↓, 2,   PKM2↓, 2,   Pyruv↑, 1,   SIRT1↓, 1,   SIRT1↑, 1,   SSAT↑, 1,   TCA↓, 3,   TCA↑, 2,   β-oxidation↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 2,   Apoptosis↓, 2,   Apoptosis↑, 36,   aSmase↝, 1,   BAD?, 1,   BAD↓, 2,   BAD↑, 5,   Bak↑, 5,   BAX↑, 39,   BAX⇅, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 63,   Bcl-2↑, 1,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 33,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 7,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 7,   BNIP3↑, 1,   BOK↑, 2,   Casp↑, 4,   Casp↝, 1,   cl‑Casp12↑, 1,   Casp2↑, 4,   Casp3↓, 1,   Casp3↑, 57,   cl‑Casp3↑, 8,   Casp7↑, 5,   cl‑Casp7↑, 1,   Casp8↑, 13,   cl‑Casp8↑, 3,   proCasp8↑, 2,   pro‑Casp8↑, 1,   Casp9↑, 37,   cl‑Casp9↑, 6,   cFLIP↓, 2,   CSR1↑, 1,   Cyt‑c↑, 28,   Diablo↑, 6,   DR5↑, 13,   FADD↑, 5,   Fas↓, 1,   Fas↑, 12,   FasL↑, 5,   Ferroptosis↑, 1,   GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 4,   IAP2/BIRC3↓, 2,   IAP2/BIRC3↑, 1,   iNOS↓, 7,   Mcl-1?, 1,   Mcl-1↓, 106,   Mcl-1↑, 2,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 3,   MDM2↑, 1,   MOMP↓, 1,   NAIP↓, 2,   NOXA↑, 3,   p38↓, 3,   p38↑, 8,   p‑p38↓, 1,   p‑p38↑, 1,   PUMA↑, 4,   Pyro↑, 2,   survivin↓, 36,   TRAIL↑, 3,   TumCD↓, 1,   TumCD↑, 5,   XIAP↓, 19,   XIAP↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 38,   Akt↑, 4,   p‑Akt↓, 12,   AKT1↓, 1,   Akt2↓, 1,   CK2↓, 2,   cMET↓, 1,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 12,   EphB4↓, 1,   ERK↓, 11,   p‑ERK↓, 5,   p‑ERK↑, 1,   FLT4↓, 1,   HER2/EBBR2↓, 3,   IGF-1R↓, 4,   IKKα↓, 3,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 2,   JAK1↓, 2,   JAK2↓, 7,   JNK↓, 3,   JNK↑, 10,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK?, 1,   MAPK↓, 7,   MAPK↑, 4,   p‑MAPK↑, 1,   MEK↓, 3,   p‑MEK↑, 1,   mTOR↓, 19,   p‑mTOR↓, 5,   p‑p42↓, 1,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 27,   p‑PI3K↓, 2,   PI3K/Akt↓, 1,   PIAS-3↑, 2,   PKA↓, 1,   PKCδ↓, 3,   PTEN↓, 1,   PTEN↑, 8,   PTPN6↑, 1,   Raf↓, 1,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 2,   RTK-RAS↓, 1,   SHP1↑, 2,   Sp1/3/4↓, 4,   Src↓, 4,   Src↑, 1,   STAT↓, 1,   STAT3↓, 25,   STAT3↑, 1,   p‑STAT3↓, 4,   STAT5↓, 1,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 4,   CBP↓, 1,   cJun↓, 3,   cJun↑, 1,   cMyc↓, 10,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 1,   EZH2↓, 2,   FOXM1↓, 2,   FOXO↑, 2,   FOXO3↑, 3,   H3↑, 2,   H4↑, 1,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 5,   HDAC1↓, 1,   HDAC10↑, 1,   HDAC4↓, 1,   HES1↓, 1,   miR-200c↑, 1,   miR-205↑, 1,   miR-21↓, 2,   miR-29b↓, 1,   miR-34a↑, 2,   miR-34b-5p↑, 1,   miR-384↑, 1,   Myc↓, 3,   OCT4↓, 3,   other↓, 2,   other↝, 2,   SOX2↓, 1,   SOX4↓, 1,   SPP1↓, 1,   SUV39H↓, 1,   TCF-4↓, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 5,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 11,   GRP78/BiP↑, 4,   Hsc70↓, 1,   HSF1↓, 1,   HSP27↓, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 6,   IRE1↑, 2,   PERK↑, 2,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 2,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 3,   p62↓, 1,   PARK2↑, 1,   TumAuto↑, 3,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   ATM↑, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DNA-PK↓, 1,   DNAdam↓, 1,   DNAdam↑, 8,   mt-DNAdam↑, 1,   DNArepair↓, 1,   ERCC1↓, 2,   ERCC4/XPF↓, 1,   hTERT/TERT↓, 2,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 3,   P53?, 1,   P53↓, 2,   P53↑, 21,   PARP↓, 1,   PARP↑, 8,   PARP↝, 1,   cl‑PARP↑, 29,   PARP1↓, 1,   PCNA↓, 5,   SIRT6↑, 1,   Telomerase↓, 4,   TOP1↓, 3,   TOP2↓, 1,   TP53↑, 1,   UHRF1↓, 1,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 4,   CDK2↓, 14,   p‑CDK2↓, 1,   CDK4↓, 14,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 9,   CDK8↓, 1,   CHK1↓, 1,   Chk2↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 7,   cycD1/CCND1↓, 29,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 10,   cycE1↓, 1,   E2Fs↓, 1,   Ki-67↓, 8,   mitA↑, 1,   P21?, 1,   P21↓, 2,   P21↑, 12,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 8,   pRB↑, 1,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA↑, 37,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 2,   CD133↓, 1,   cFos↓, 3,   CSCs↓, 7,   Diff↑, 1,   FBXW7↝, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1↓, 2,   p‑IGF-1↓, 1,   IGFBP1↑, 1,   Ki-67↓, 8,   mTORC1↓, 1,   Nanog↓, 4,   Nestin↓, 1,   NOTCH↓, 7,   NOTCH1↓, 2,   NOTCH1↑, 1,   NOTCH3↓, 1,   p300↓, 1,   Shh↓, 1,   p‑STAT1↓, 1,   TumCG↓, 17,   TumCP?, 1,   TumCP↓, 29,   tyrosinase↓, 1,   Wnt?, 1,   Wnt↓, 13,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 6,   AXL↓, 1,   BACH1↓, 1,   Ca+2↓, 3,   Ca+2↑, 6,   Ca+2↝, 1,   CAFs/TAFs↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 8,   EM↑, 1,   EMT↓, 18,   FAK↓, 6,   p‑FAK↓, 1,   Fibronectin↓, 4,   GLI2↓, 1,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   LAMs↓, 1,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP16↓, 1,   MMP2↓, 22,   MMP3↓, 5,   MMP7↓, 6,   MMP9↓, 29,   MMP9↑, 1,   MMPs↓, 11,   MUC4↓, 1,   N-cadherin↓, 10,   NM23↑, 1,   p‑p44↓, 2,   PDGF↓, 1,   Rac1↓, 1,   Slug↓, 6,   p‑SMAD2↓, 1,   SMAD3↓, 2,   p‑SMAD3↓, 1,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 11,   TET1↑, 1,   TGF-β↓, 5,   TIMP1↑, 1,   TIMP2↑, 3,   TumCA↑, 1,   TumCI↓, 12,   TumCMig↓, 10,   TumMeta↓, 16,   Twist↓, 10,   uPA↓, 7,   Vim↓, 12,   Zeb1↓, 5,   ZEB2↓, 1,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 14,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 30,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 2,   Hif1a↓, 20,   NO↓, 2,   VCAM-1↓, 1,   VEGF↓, 31,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   GLUT1↓, 3,   MMP↓, 20,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 22,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR2↓, 1,   CXCR4↓, 7,   CXCR4↑, 1,   DR4↑, 3,   ICAM-1↓, 1,   IL1↓, 2,   IL10↓, 2,   IL12↓, 1,   IL1β↓, 4,   IL2↑, 1,   IL4↓, 1,   IL6↓, 9,   IL8↓, 1,   Inflam↓, 8,   M2 MC↓, 1,   mPGES-1↓, 1,   NF-kB?, 1,   NF-kB↓, 32,   NF-kB↑, 2,   NLRP3↑, 1,   p65↓, 4,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 9,   SOCS-3↑, 1,   SOCS1↑, 1,   T-Cell↝, 1,   TCF↑, 1,   TLR4↓, 1,   TLR4↝, 1,   TNF-α↓, 8,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   PLC↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,   ER-α36↓, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 9,   BioAv↑, 6,   BioAv↝, 1,   ChemoSen↑, 35,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1B1↑, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 1,   Dose↝, 12,   Dose∅, 2,   eff↓, 9,   eff↑, 27,   Half-Life↓, 3,   Half-Life↝, 3,   MDR1↓, 1,   NAT↓, 1,   P-gp/ABCB1↓, 5,   RadioS↑, 9,   selectivity?, 1,   selectivity↑, 12,   Synergy↑, 29,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 2,   AR↓, 5,   AST↓, 1,   p‑BRCA1↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 12,   EZH2↓, 2,   FOXM1↓, 2,   HEC1↓, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 2,   IL6↓, 9,   LDH↓, 3,   Myc↓, 3,   NOS2↓, 1,   PD-L1↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 3,   cardioP↑, 1,   chemoP?, 1,   chemoP↑, 4,   chemoPv↑, 6,   hepatoP↑, 1,   IMPDH1↓, 1,   IMPDH2↓, 1,   neuroP↑, 2,   NP/CIPN↓, 1,   ORR↑, 1,   OS↑, 1,   radioP↑, 2,   RenoP↑, 2,   toxicity↓, 5,   toxicity↝, 3,   toxicity∅, 1,   TumVol↓, 6,   TumW↓, 4,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 581

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 9,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 2,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 1,   Keap1↝, 1,   MDA↓, 1,   NRF2↑, 2,   Prx↑, 1,   ROS↓, 9,   mt-ROS?, 1,   SOD↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   ATP↑, 1,   glucose↓, 1,   LDHA↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Casp3?, 1,   Casp3↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

PI3K↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP1↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   MMP9↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   COX2/PTGS2↑, 1,   IL18↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 6,   Inflam↑, 1,   pol-M2 MC↑, 1,   NF-kB↓, 4,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 2,   BioAv↝, 3,   Half-Life↝, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 2,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiArt↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 2,   antiPs↑, 2,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 4,   memory↑, 1,   neuroP↑, 8,   Obesity↓, 1,   Stroke↓, 1,   toxicity↓, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiP↑, 1,   AntiViral↑, 2,   Bacteria↓, 2,   GutMicro↑, 1,  
Total Targets: 81

Scientific Paper Hit Count for: Mcl-1, myeloid cell leukemia 1
7 Gossypol/AT-101
6 Citric Acid
6 Fisetin
4 Curcumin
3 Artemisinin
3 Baicalein
3 Chemotherapy
3 Emodin
3 Gambogic Acid
3 Garcinol
3 Luteolin
3 Phenethyl isothiocyanate
3 Quercetin
3 Silymarin (Milk Thistle) silibinin
2 3-bromopyruvate
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Cisplatin
2 chaetocin
2 Chrysin
2 Formononetin
2 Hibiscus sabdariffa
2 Honokiol
2 Morin
2 Nimbolide
2 Resveratrol
2 Thymoquinone
1 Silver-NanoParticles
1 Allyl isothiocyanate
1 Sorafenib (brand name Nexavar)
1 Ashwagandha(Withaferin A)
1 Berberine
1 Betulinic acid
1 Bufalin/Huachansu
1 Cat’s Claw
1 Celastrol
1 immunotherapy
1 Cucurbitacin
1 Docetaxel
1 methylseleninic acid
1 CUSP9
1 Electrical Pulses
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Ferulic acid
1 Fucoidan
1 Galloflavin
1 Paclitaxel/Taxol
1 carboplatin
1 HydroxyTyrosol
1 Isobavachalcone
1 isoorientin
1 Isovitexin
1 Kaempferol
1 Licochalcone A
1 Lemongrass Extract/Citral
1 Methylene blue
1 Photodynamic Therapy
1 Magnolol
1 Magnetic Fields
1 Mangiferin
1 Melatonin
1 Mushroom Shiitake, AHCC
1 Naringin
1 Oleuropein
1 Patchouli Oil (Pogostemon cablin)
1 Piperlongumine
1 Rauwolfia serpentina/Indian Snakeroot
1 Sulforaphane (mainly Broccoli)
1 Shikonin
1 Aflavin-3,3′-digallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:182  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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