Synergy Cancer Research Results

Synergy, Synergy: Click to Expand ⟱
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Synergy — Interaction in which two or more agents, treatments, or biological interventions produce a combined effect greater than would be expected from their individual effects. In pharmacology and cancer research, synergy commonly refers to enhanced therapeutic efficacy when a compound is combined with chemotherapy, radiation, targeted therapy, or another bioactive agent.

Typical modulation in cancer: ↑ synergy is generally favorable when it increases tumor-cell killing, suppresses proliferation, enhances apoptosis or ferroptosis, or improves sensitivity to anticancer therapy. Synergy should be distinguished from simple additive effects and ideally supported by quantitative combination analysis such as combination index, Bliss independence, Loewe additivity, or related methods.

Typical modulation in Alzheimer’s disease: Context-dependent. Synergy may describe enhanced neuroprotective, anti-inflammatory, antioxidant, or cognitive effects produced by combinations of compounds or treatments, but it is not a disease-specific molecular pathway.
Scientific Papers found: Click to Expand⟱
6124- CHr,  EGCG,    The anticancer flavonoid chrysin induces the unfolded protein response in hepatoma cells
- in-vitro, HCC, HepG2
TumCG↓, Apoptosis↓, GRP78/BiP↑, eff↑, cl‑Casp7↑, cl‑PARP↑, Synergy↑, UPR↑, ER Stress↑, p‑eIF2α↑, XBP-1↝, Proteasome↓,
2803- CHr,  5-FU,    Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells
- in-vitro, GC, AGS
ChemoSen↑, TumCCA↑, Synergy↑, MDR1↓,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, Synergy↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2/PTGS2↓, NF-kB↓, PDK1 / PDPK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, Synergy↑, Synergy↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, Synergy↑,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2/PTGS2↓, Synergy↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, Synergy↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2789- CHr,    Anticancer Activity of Ether Derivatives of Chrysin
- Review, Var, NA
eff↑, COX2/PTGS2↓, PGE2↓, Synergy↑,
2790- CHr,    Chrysin: Pharmacological and therapeutic properties
- Review, Var, NA
*hepatoP↑, *neuroP↓, *ROS↓, *cardioP↑, *Inflam↓, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, MMP9↓, MMP2↓, TIMP1↑, TIMP2↑, BioAv↑, HK2↓, ROS↑, MMP↓, Casp3↑, ADP:ATP↑, Apoptosis↑, ER Stress↑, UPR↑, GRP78/BiP↝, Synergy↑, Ca+2↑,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, Synergy↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
1576- Citrate,    Targeting citrate as a novel therapeutic strategy in cancer treatment
- Review, Var, NA
TCA↓, T-Cell↝, Glycolysis↓, PKM2↓, PFK2?, SDH↓, PDH↓, β-oxidation↓, CPT1A↓, FASN↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, cl‑PARP↑, Hif1a↓, GLUT1↓, angioG↓, Ca+2↓, ROS↓, eff↓, Dose↓, Synergy↑, Mcl-1↓, HK2↓, IGF-1R↓, PTEN↑, citrate↓, Dose∅, ChemoSen↑, eff↑, eff↑, eff↑,
4770- CoQ10,  VitK2,    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
- in-vitro, BC, MDA-MB-231
other↑, *antiOx↑, Risk↓, other↑, TumMeta↓, ECM/TCF↓, Akt2↓, Ferroptosis↑, Synergy↑,
3994- CoQ10,  Se,    Coenzyme Q10 Supplementation in Aging and Disease
- Review, AD, NA - Review, Park, NA
*AntiAge↑, *cardioP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *QoL↑, *neuroP↑, *Dose↝, *BP↓, *IGF-1↑, *IGFBP1↑, *Synergy↑, *LDL↓, *HDL↑, *Synergy↑, *other↑, *RenoP↑, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *other∅,
1572- Cu,    Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
- Review, NA, NA
eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, Apoptosis↑, selectivity↑, Synergy↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,
6200- Cuc,  GEM,    Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer
- in-vivo, PC, NA
Synergy↑, TumCG↓, Bcl-xL↓, Bcl-2↓, cMyc↓, Casp↑, STAT3↓, JAK2↓,
1609- CUR,  EA,    Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells
- in-vitro, Cerv, NA
Synergy↑, Dose∅, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑, Dose∅,
1978- CUR,    Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells
- in-vitro, Cerv, HeLa
TrxR1↓, ROS↑, DNA-PK↑, Synergy↑, Trx↓, Trx1↓,
6214- CUR,    Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve
TumCD↓, TumCI↓, *Inflam↓, *antiOx↓, *AntiTum↓, NF-kB↓, COX2/PTGS2↓, Casp9↓, ROS↑, BioAv↑, RadioS↑, ChemoSen↑, Imm↑, PhotoS↑, sonoS↑, 5LO↓, iNOS↓, IL2↓, TNF-α↓, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, Apoptosis↑, ER Stress↑, cycD1/CCND1↓, CDK2↓, CycB/CCNB1↓, TumCCA↑, MMPs↓, *radioP↑, chemoP↑, hepatoP↑, cardioP↑, Synergy↑, PhotoS↑, eff↑, ROS↑, GSH↓,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *BioAv↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2/PTGS2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, Synergy↑,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2/PTGS2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1/CCL2↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *Synergy↑, Synergy↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
129- CUR,    Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation
- vitro+vivo, Pca, LNCaP
JNK↓, H3K4↓, TumCG↓, Apoptosis↑, Synergy↑,
130- CUR,    Maspin Enhances the Anticancer Activity of Curcumin in Hormone-refractory Prostate Cancer Cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
BAD↝, BAX↝, Synergy↑,
12- CUR,    Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
- in-vitro, MB, DAOY
HH↓, Shh↓, Gli1↓, PTCH1↓, cMyc↓, n-MYC↓, cycD1/CCND1↓, Bcl-2↓, NF-kB↓, Akt↓, β-catenin/ZEB1↓, survivin↓, Apoptosis↑, ChemoSen↑, RadioS↑, Synergy↑,
3583- CUR,    Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers
- Review, Arthritis, NA
*TNF-α↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMPs↓, *Synergy↑,
3588- CUR,    The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
- Review, AD, NA
*cognitive↝, *BioAv↑, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↓, *IL6↓, *IL8↓, *IL12↓, *ROS↓, *RNS↓, *antiOx↑, *BBB↑, *BioAv↓, *cognitive↑, *memory↑, *tau↓, *Synergy↑,
3582- CUR,  PI,    Therapeutic and Preventive Effects of Piperine and its Combination with Curcumin as a Bioenhancer Against Aluminum-Induced Damage in the Astrocyte Cells
*Synergy↑, *IL6↓, *TGF-β↓, *BioAv↑,
3579- CUR,  AgNPs,    Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin
- Review, NA, NA
*IronCh↑, *BioAv↑, *antiOx↑, *Inflam↓, *BioAv↑, ROS↑, *neuroP↑, *Synergy↑,
3578- CUR,  SIL,    Curcumin, but not its degradation products, in combination with silibinin is primarily responsible for the inhibition of colon cancer cell proliferation
- in-vitro, CRC, DLD1
Synergy↑, BioAv↓, TumCG↓,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2/PTGS2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *Synergy↑,
4830- CUR,    Curcumin and Its Derivatives Induce Apoptosis in Human Cancer Cells by Mobilizing and Redox Cycling Genomic Copper Ions
- in-vitro, Var, NA
Synergy↑, ROS↑, DNAdam↑, TumCG↓, Apoptosis↑, eff↓, Fenton↑, Synergy↑,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, Synergy↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
6593- DAS,    Dasatinib: a potent SRC inhibitor in clinical development for the treatment of solid tumors
TumCP↓, TumCI↓, TumMeta↓, Synergy↑, Src↓,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1 / PDPK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2/PTGS2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, Synergy↑, Synergy↑, other↝, RadioS↑, toxicity↓, Dose↝, Synergy↑, Synergy↑, Synergy↑, toxicity↝, eff↓,
4901- DCA,  Sal,    Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
- Review, NSCLC, NA
Glycolysis↓, OXPHOS↑, PDKs↓, ROS↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, RadioS↑, TumAuto↑, mTOR↓, LC3s↓, p62↑, TumCG↓, OS↑, toxicity↝, ChemoSen↑, Synergy↑, Synergy↑, Ferritin↓, CSCs↓, EMT↓, ROS↑, Cyt‑c↑, Casp3↑, ER Stress↑, selectivity↑, Synergy↑, TumCG↓,
1878- DCA,  5-FU,    Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer
- in-vitro, CRC, LS174T - in-vitro, CRC, LoVo - in-vitro, CRC, SW-620 - in-vitro, CRC, HT-29
tumCV↓, Synergy↑, PDKs↓, lactateProd↓, Glycolysis↓, mitResp↑, TumCCA↑, Bcl-2↓, BAX↑, Casp3↑,
1876- DCA,  Chemo,    In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines
- in-vivo, Lung, H727
Synergy↑, TumCG↓, Glycolysis↓, mitResp↑,
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, Synergy↑, ROS↑, PDK1 / PDPK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
1881- DCA,  Chemo,    Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report
- in-vitro, NA, HT1080 - in-vitro, NA, WI38 - Case Report, Var, NA
Synergy↑, selectivity↑, OS↑,
1884- DCA,  Sal,    Dichloroacetate and Salinomycin Exert a Synergistic Cytotoxic Effect in Colorectal Cancer Cell Lines
- in-vitro, CRC, DLD1 - in-vitro, CRC, HCT116
Synergy↑, pH↓, PDKs↓, Warburg↓,
1873- DCA,    Dual-targeting of aberrant glucose metabolism in glioblastoma
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
PDKs↓, Synergy↑, selectivity↑, MMP↓, ROS↑, Apoptosis↑, Warburg↓, Synergy↑, Dose∅, toxicity∅,
1867- DCA,  Chemo,    Sensitization of breast cancer cells to paclitaxel by dichloroacetate through inhibiting autophagy
- in-vivo, BC, NA - in-vitro, BC, NA
TumCG↓, Synergy↑, OS↑, PDKs↓, PDH↑,
1866- DCA,  MET,  BTZ,    Targeting metabolic pathways alleviates bortezomib-induced neuropathic pain without compromising anticancer efficacy in a sex-specific manner
- in-vivo, NA, NA
Synergy↑, TumCG↓, Hif1a↓, PDH↑, lactateProd↓, TumVol↓, TumW↓, Glycolysis↑, neuroP↑,
1885- DCA,    Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW-620 - in-vitro, CRC, HT-29
SMCT1∅, eff↓, eff↑, Synergy↑, PDKs↓, MMP↓, Glycolysis↓, mitResp↑, ROS↑, eff↑,
6706- DFC,  MET,    Frontiers | Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells
- in-vitro, AML, U937
lactateProd↓, TumCP↓, Synergy↑, Glycolysis↓,
6745- DHA,    Omega-3 fatty acid DHA induces ferroptosis in colorectal cancer patient-derived organoids and drug-tolerant cells
- in-vitro, CRC, HT29
tumCV↓, selectivity↑, Ferroptosis↑, lipid-P↑, mt-ROS↑, ChemoSen↑, *toxicity↓, TumCG↓, Synergy↑, Synergy↑, Dose↝, mtDam↑, *Inflam↓, *chemoP↑, Dose↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
Synergy↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1/ATG6↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1850- dietFMD,    Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression
- in-vivo, CRC, NA
TumCP↑, angioG↓, CD8+↑, GutMicro↑, Synergy↑,
1846- dietFMD,  VitC,    A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer
- Study, Var, NA
TumCG↓, ChemoSen↑, ChemoSideEff↓, ROS↑, Fenton↑, H2O2↑, Synergy↑, HO-1↓, DNAdam↑, Synergy↑,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, Synergy↑, ROS↑, Akt↑, Casp3↑,
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, Synergy↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, Synergy↑,
1810- dietKeto,  Oxy,    The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer
- in-vivo, Var, NA
BG↓, TumCG↓, OS↑, eff↑, Dose∅, KeyT↑, Synergy↑, cachexia↓, ChemoSen↑, *ROS↓, ROS↑, lipid-P↑, selectivity↑, toxicity∅,

Showing Research Papers: 101 to 150 of 348
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 348

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CBR1↓, 1,   KAI1/CD82↑, 1,   miR-375↑, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ATF3↑, 1,   Catalase↓, 3,   Catalase↑, 2,   compI↓, 1,   CYP1A1↑, 1,   Fenton↑, 5,   Ferroptosis↓, 1,   Ferroptosis↑, 12,   frataxin↑, 1,   GPx↓, 3,   GPx↑, 2,   GPx4↓, 3,   GPx4↑, 1,   GSH↓, 18,   GSH↑, 1,   GSH↝, 1,   GSR↑, 1,   GSSG↑, 1,   GSTP1/GSTπ↓, 2,   GSTs↓, 1,   GSTZ1↓, 1,   H2O2↑, 5,   HO-1↓, 3,   HO-1↑, 9,   hyperG↓, 1,   Iron↑, 5,   i-Iron↑, 1,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 10,   MDA↓, 1,   MDA↑, 4,   Mets↑, 1,   MFN2↑, 1,   NQO1↑, 3,   NRF2↓, 10,   NRF2↑, 13,   OXPHOS↓, 6,   OXPHOS↑, 3,   OXPHOS↝, 1,   PARK2↑, 1,   PrxI↓, 1,   PYCR1↓, 1,   ROS?, 2,   ROS↓, 17,   ROS↑, 159,   ROS⇅, 3,   i-ROS↑, 1,   mt-ROS↑, 3,   SIRT3↓, 1,   SIRT3↑, 2,   SOD↓, 4,   SOD↑, 3,   Trx↓, 3,   Trx1↓, 1,   TrxR↓, 3,   TrxR1?, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 4,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   KLF5↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   AIF↑, 2,   ATP↓, 13,   ATP↑, 1,   mt-ATP↓, 1,   BCR-ABL↓, 1,   CDC2↓, 2,   CDC25↓, 1,   EGF↓, 2,   ETC↑, 1,   ETC↝, 1,   FGFR1↓, 1,   Insulin↓, 1,   MEK↓, 4,   mitResp↓, 1,   mitResp↑, 3,   MMP↓, 50,   MMP↑, 2,   Mortalin↓, 1,   MPT↑, 3,   mtDam↑, 8,   OCR↓, 1,   OCR↑, 2,   PINK1↑, 1,   Raf↓, 2,   c-Raf↓, 1,   SDH↓, 1,   XIAP↓, 10,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 2,   ACLY↓, 4,   p‑ACLY↓, 1,   ACSL4↑, 2,   adiP↑, 1,   ALAT↓, 4,   AMP↑, 1,   AMPK↑, 15,   ATG7↑, 2,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 2,   cMyc↓, 20,   CPT1A↓, 1,   CYP3A4↓, 1,   ECAR↓, 1,   FASN↓, 4,   FASN↑, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 5,   GlucoseCon↑, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 30,   Glycolysis↑, 1,   Histones↝, 1,   HK2↓, 13,   HMG-CoA↓, 9,   KeyT↑, 1,   lactateProd↓, 10,   lactateProd↑, 1,   LDH↓, 8,   p‑LDH↓, 1,   LDHA↓, 5,   LDL↓, 3,   lipoGen↓, 1,   NADH:NAD↓, 1,   NADPH↓, 4,   NADPH↑, 2,   PDH↓, 1,   PDH↑, 5,   p‑PDH↑, 1,   PDHB↓, 1,   PDK1 / PDPK1↓, 7,   PDK3↑, 1,   PDKs↓, 9,   PFK↓, 2,   PFK2?, 1,   PI3K/Akt↓, 1,   PKM2↓, 10,   POLD1↓, 1,   PPARα↓, 2,   PPARγ↓, 1,   PPARγ↑, 3,   p‑S6K↓, 1,   SIRT1↓, 3,   SIRT1↑, 4,   SIRT2↓, 1,   SREBP2↓, 2,   TCA↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 8,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 100,   ASK1↑, 1,   BAD↑, 4,   BAD↝, 1,   Bak↑, 4,   BAX↓, 3,   BAX↑, 53,   BAX↝, 2,   Bax:Bcl2↑, 12,   Bcl-2↓, 58,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 13,   Bcl-xL↑, 1,   BID↑, 1,   BIM↑, 6,   Casp↑, 18,   Casp1↑, 1,   Casp12?, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 70,   cl‑Casp3↑, 7,   cl‑Casp3⇅, 1,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp7↑, 4,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 7,   cl‑Casp8↑, 2,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 37,   cl‑Casp9↑, 5,   proCasp9↑, 1,   cFLIP↓, 2,   Chk2↓, 1,   CK2↓, 4,   Cupro↑, 1,   Cyt‑c↑, 33,   Diablo↑, 4,   DR4↑, 2,   DR5↑, 11,   FADD↑, 2,   Fas↑, 9,   FasL↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 12,   GSDME-N↑, 1,   HEY1↓, 1,   hTERT/TERT↓, 9,   IAP1↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 5,   iNOS↑, 2,   JNK↓, 2,   JNK↑, 8,   p‑JNK↓, 3,   p‑JNK↑, 1,   MAPK↓, 7,   MAPK↑, 4,   MAPK↝, 1,   Mcl-1↓, 15,   Mcl-1↑, 1,   MDM2↓, 3,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↑, 1,   Myc↓, 4,   Myc↑, 1,   Necroptosis↑, 3,   necrosis↑, 2,   NOXA↑, 1,   p27/CDKN1B↑, 7,   p38↓, 1,   p38↑, 5,   p‑p38↓, 1,   p‑p38↑, 2,   Paraptosis↑, 2,   Proteasome?, 1,   Proteasome↓, 3,   PUMA↑, 2,   Pyro↑, 2,   survivin↓, 19,   Telomerase↓, 6,   TRAIL↑, 1,   TRPV1↑, 1,   TumCD↓, 1,   TumCD↑, 16,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 51,   Akt↑, 10,   p‑Akt↓, 13,   Akt2↓, 1,   AMPKα↑, 1,   cSrc↓, 1,   EF-1α↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 5,   miR-25-5p↓, 1,   p70S6↓, 1,   SOX9?, 1,   Sp1/3/4↓, 7,   TRPV2↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↝, 1,   cJun↓, 7,   cJun↑, 3,   EZH2↓, 2,   H3↑, 2,   ac‑H3↑, 3,   H3K4↓, 1,   H4↑, 1,   ac‑H4↑, 3,   HATs↓, 2,   HATs↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   other↓, 5,   other↑, 7,   other↝, 10,   PhotoS↑, 3,   p‑pRB↓, 1,   sonoS↑, 2,   tumCV↓, 26,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 7,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 32,   GRP78/BiP↓, 1,   GRP78/BiP↑, 9,   GRP78/BiP↝, 1,   GRP94↑, 1,   HSP27↓, 3,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 4,   HSP72↑, 1,   HSP90↓, 7,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 3,   PERK↑, 3,   UPR↑, 8,   XBP-1↓, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 2,   autoF↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   p‑Beclin-1/ATG6↑, 1,   BNIP3↑, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 7,   LC3s↓, 1,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 4,   p62↑, 6,   SESN2↑, 1,   TumAuto↑, 24,   TumAuto⇅, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   CHK1↓, 2,   DNA-PK↑, 2,   DNAdam↑, 36,   DNArepair↓, 1,   DNArepair↑, 1,   DNMT1↓, 7,   DNMT3A↓, 2,   DNMTs↓, 5,   m-FAM72A↓, 1,   GADD45A↑, 1,   MGMT↓, 1,   p16↑, 1,   P53↓, 2,   P53↑, 30,   p‑P53↑, 2,   PARP↑, 9,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 30,   cl‑PARP↝, 1,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 11,   SIRT6↓, 1,   TP53↓, 2,   TP53↑, 3,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK2↓, 20,   CDK4↓, 25,   CDK4↑, 3,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   CycB/CCNB1↓, 9,   cycD1/CCND1↓, 37,   CycD3↓, 3,   cycE/CCNE↓, 13,   cycE1↓, 1,   E2Fs↓, 2,   mitA↑, 1,   P21?, 2,   P21↓, 1,   P21↑, 20,   RB1↑, 1,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 4,   TumCCA↑, 69,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   ALDH1A1↓, 1,   CD133↓, 3,   CD133↑, 1,   CD24↓, 1,   CD44↓, 6,   cFos↓, 7,   cMYB↓, 2,   CSCs↓, 31,   CSCsMark↓, 1,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   Diff↓, 3,   Diff↑, 3,   EMT↓, 41,   EMT↑, 2,   ERK↓, 11,   ERK↑, 4,   ERK↝, 1,   p‑ERK↓, 10,   FGF↓, 1,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 7,   FOXO4↓, 1,   FOXO4↑, 1,   Gli↓, 1,   Gli1↓, 3,   GSK‐3β↓, 4,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   HDAC↓, 18,   HDAC1↓, 2,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC8↓, 1,   HH↓, 5,   HMGCR↓, 1,   HMGCR↑, 1,   HMGCR⇅, 1,   HMTs↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGFBP1↑, 2,   IGFBP3↑, 1,   KLF4↓, 1,   Let-7↑, 2,   LRP6↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   mTOR↓, 33,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   mTORC1↓, 4,   p‑mTORC1↓, 1,   mTORC2↓, 1,   n-MYC↓, 2,   Nanog↓, 7,   Nestin↓, 3,   NOTCH↓, 5,   NOTCH↑, 1,   NOTCH1↓, 6,   NOTCH1↑, 4,   NOTCH3↓, 3,   OCT4↓, 5,   P70S6K↓, 2,   p‑P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 39,   PI3K↑, 4,   p‑PI3K↓, 2,   PTCH1↓, 2,   PTCH2↓, 1,   PTEN↑, 10,   RAS↓, 5,   SAL↑, 1,   Shh↓, 3,   SHP1↑, 1,   Smo↓, 1,   SOX2↓, 4,   Src↓, 1,   STAT↓, 2,   STAT3↓, 37,   STAT3↝, 1,   p‑STAT3↓, 6,   p‑STAT3↑, 4,   STAT4↓, 1,   STAT5↓, 1,   STAT6↓, 2,   TCF↓, 1,   TCF↑, 1,   TCF-4↓, 1,   TOP1↓, 5,   TOP2↓, 2,   TOP2↑, 1,   TRPM7↓, 1,   TumCG↓, 60,   TumCG↑, 2,   tyrosinase↓, 1,   Wnt↓, 16,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 4,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 5,   AXL↓, 1,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 11,   CAFs/TAFs↓, 1,   cal2↑, 1,   CD11b↑, 1,   CDKN1C/p57↑, 1,   CLDN1↓, 3,   CLDN2↓, 1,   CLDN2↑, 1,   CXCL12↓, 2,   E-cadherin↓, 4,   E-cadherin↑, 21,   ER-α36↓, 2,   FAK↓, 3,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 5,   GLI2↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   ITGB4↓, 1,   Ki-67↓, 15,   Ki-67↑, 1,   KLF2↓, 1,   KRAS↓, 2,   L-sel↑, 1,   LAMs↓, 2,   MALAT1↓, 2,   MET↓, 1,   miR-200b↑, 1,   miR-29b↓, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP13↓, 1,   MMP15↓, 1,   MMP2↓, 35,   MMP2↑, 1,   MMP3↓, 1,   MMP7↓, 5,   MMP9↓, 41,   MMP9↑, 2,   MMPs↓, 17,   MUC1↑, 1,   MUC4↓, 1,   N-cadherin↓, 13,   PAK1↓, 1,   PDGF↓, 2,   PKA↓, 1,   PKA↑, 1,   PKCδ↓, 4,   RECK↑, 1,   Rho↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   ROCK1↓, 2,   Slug↓, 9,   Smad1↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 12,   SOX4↓, 1,   STAC2↓, 1,   TET1↑, 4,   TGF-β↓, 11,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↑, 4,   Treg lymp↓, 2,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 41,   TumCMig↓, 31,   TumCMig↑, 1,   TumCP↓, 48,   TumCP↑, 2,   TumMeta↓, 33,   TumMeta↑, 2,   Twist↓, 7,   uPA↓, 9,   uPAR↓, 1,   Vim?, 1,   Vim↓, 18,   Zeb1↓, 10,   Zeb1↑, 1,   ZEB2↓, 2,   ZO-1↑, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 22,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 50,   angioG↑, 1,   ATF4↓, 1,   ATF4↑, 6,   ECM/TCF↓, 1,   EGFR↓, 17,   eNOS↓, 2,   eNOS↑, 1,   EPR↓, 1,   EPR↑, 1,   HIF-1↓, 4,   Hif1a↓, 31,   Hif1a↑, 1,   miR-126↑, 1,   NO↓, 4,   NO↑, 2,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 52,   VEGFR2/KDR/Flk1↓, 7,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   CellMemb↑, 1,   GLUT1↓, 6,   GLUT1↑, 1,   GLUT3↑, 1,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↝, 1,   SMCT1∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 37,   COX2/PTGS2↑, 3,   CRP↓, 2,   CXCR4↓, 9,   FOXP3↓, 1,   HCAR2↑, 1,   HMGB1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 3,   IKKα↓, 3,   IL1↓, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 1,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 9,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL6↓, 19,   IL8↓, 5,   Imm↑, 11,   INF-γ↑, 1,   Inflam↓, 15,   IκB↑, 1,   JAK↓, 3,   JAK1↓, 1,   JAK2↓, 7,   M2 MC↓, 2,   MCP1/CCL2↓, 3,   MIP2↓, 1,   NF-kB↓, 53,   NF-kB↑, 4,   NF-kB↝, 1,   NK cell↑, 4,   p65↓, 4,   PD-1↓, 3,   PD-L1↓, 5,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 15,   PSA↓, 4,   PSA∅, 1,   T-Cell↑, 1,   T-Cell↝, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 2,   TNF-α↓, 13,   TNF-α↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2,   pH↑, 1,   e-pH↑, 4,   i-pH↓, 1,   TIM-3↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,   PP2A↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 9,   CDK6↓, 8,   CDK6↑, 3,   COMT↓, 2,   CYP19↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   GR↑, 1,   RANKL↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 17,   BioAv↑, 30,   BioAv↝, 10,   BioEnh↑, 1,   chemoR↓, 1,   ChemoSen↓, 3,   ChemoSen↑, 116,   ChemoSen⇅, 2,   CYP1A2↓, 1,   CYP2C9↓, 1,   DDS↑, 1,   Dose?, 1,   Dose↓, 5,   Dose↑, 7,   Dose↝, 35,   Dose∅, 15,   eff↓, 30,   eff↑, 83,   eff↝, 5,   eff∅, 1,   Half-Life↓, 7,   Half-Life↑, 4,   Half-Life↝, 5,   Half-Life∅, 1,   MDR1↓, 4,   MRP1/ABCC1↓, 1,   P450↓, 1,   RadioS↑, 42,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 64,   Synergy↑, 369,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 4,   ALP↓, 2,   AR↓, 9,   ascitic↓, 1,   AST↓, 2,   BG↓, 3,   BRCA1↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 17,   ERα/ESR1↓, 1,   EZH2↓, 2,   Ferritin↓, 2,   FOXM1↓, 2,   GutMicro↑, 5,   HER2/EBBR2↓, 5,   hTERT/TERT↓, 9,   IL6↓, 19,   Ki-67↓, 15,   Ki-67↑, 1,   KRAS↓, 2,   LDH↓, 8,   p‑LDH↓, 1,   Myc↓, 4,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PSA↓, 4,   PSA∅, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 3,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 27,   AntiCan∅, 1,   antiNeop↑, 1,   AntiTum↓, 2,   AntiTum↑, 14,   cachexia↓, 1,   cardioP↑, 5,   CardioT↓, 1,   chemoP↑, 14,   chemoPv↑, 7,   ChemoSideEff↓, 10,   fatigue↓, 2,   hepatoP↓, 1,   hepatoP↑, 5,   memory↑, 1,   NDRG1↑, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   OS↑, 26,   PDE4↓, 1,   Pin1↓, 1,   QoL↑, 3,   radioP↑, 5,   Remission↑, 2,   RenoP↑, 3,   Risk↓, 18,   Risk↑, 2,   Risk∅, 1,   toxicity↓, 14,   toxicity↑, 2,   toxicity↝, 6,   toxicity∅, 5,   TumVol↓, 13,   TumW↓, 7,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   CD8+↑, 5,   Sepsis↓, 2,  
Total Targets: 810

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 2,   diuretic↑, 2,   Stroke↓, 1,   TRPA1↑, 1,   UFR↑, 1,   UR↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 5,   antiOx↑, 53,   Catalase↑, 21,   Copper↓, 1,   Fenton↓, 1,   Ferroptosis↓, 2,   GPx↑, 17,   GSH↑, 23,   GSR↑, 3,   GSSG↓, 1,   GSSG∅, 1,   GSTA1↑, 1,   GSTs↑, 7,   H2O2↑, 1,   H2O2∅, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 16,   Iron↓, 1,   Keap1↓, 3,   Keap1↝, 1,   lipid-P↓, 20,   MDA↓, 14,   MDA↑, 1,   MPO↓, 3,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 31,   PARK2↑, 1,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 62,   ROS↝, 1,   mt-ROS?, 1,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 31,   SOD2↑, 1,   TAC↑, 4,   TBARS↓, 1,   Trx↑, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↓, 1,   ATP↑, 5,   ATP↝, 1,   DRP1/DNM1L↓, 1,   FIS1↓, 2,   Insulin↑, 1,   MMP↑, 3,   mtDam↓, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ALAT↓, 7,   AMPK↓, 1,   AMPK↑, 6,   p‑cMyc↑, 1,   CREB↑, 1,   CYP3A2↓, 1,   cytoP450↓, 1,   FASN↓, 1,   glucose↓, 5,   GlucoseCon↑, 2,   GLUT2↑, 1,   H2S↑, 1,   LDH↓, 2,   LDL↓, 5,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   PONs↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,   p‑PPARγ↓, 1,   SIRT1↑, 6,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 2,   BAX↑, 1,   Bax:Bcl2↓, 2,   Bcl-2↓, 2,   Casp3?, 1,   Casp3↓, 5,   Casp3↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 2,   Casp9↑, 1,   Cyt‑c↓, 3,   Ferroptosis↓, 2,   GADD34↓, 1,   iNOS↓, 9,   JNK↓, 2,   MAPK↓, 6,   MAPK↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 1,   TRPV3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   AntiThr↑, 2,   other↓, 3,   other↑, 10,   other↝, 4,   other∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 3,   GRP78/BiP↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3II↓, 1,   LC3II↑, 1,   MitoP↑, 2,   p62↓, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   GADD45A↑, 1,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   Diff↝, 1,   ERK↓, 2,   ERK↑, 2,   GSK‐3β↓, 5,   HDAC↓, 1,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↓, 2,   mTOR↑, 1,   neuroG↑, 1,   PI3K↓, 5,   PI3K↑, 1,   PTEN↓, 1,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 1,   TumCG∅, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AntiAg↑, 7,   AP-1↓, 3,   Ca+2?, 1,   Ca+2↑, 1,   Ca+2↝, 3,   Cartilage↑, 2,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 3,   PKCδ?, 1,   PKCδ↓, 2,   PKCδ↑, 2,   RAGE↓, 1,   serineP↓, 1,   TGF-β↓, 2,   VCAM-1↓, 4,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 2,   ATF4↓, 1,   eNOS↓, 1,   EPR↑, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO?, 1,   NO↓, 9,   NO↑, 1,   TXA2↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 12,   GastroP↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 15,   COX2/PTGS2↑, 1,   CRP↓, 6,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 3,   IL10↓, 3,   IL10↑, 1,   IL12↓, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 16,   IL2↓, 2,   IL33↓, 1,   IL4↓, 1,   IL6↓, 28,   IL8↓, 3,   Imm↓, 1,   Imm↑, 5,   Inflam↓, 74,   Inflam↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 1,   MCP1/CCL2↝, 1,   MUC2↓, 1,   MyD88↓, 1,   NF-kB↓, 25,   PGE2↓, 7,   PSA↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TLR4↑, 1,   TNF-α↓, 33,   TNF-α↑, 1,   VitD↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   AChE↓, 8,   BChE↓, 2,   BDNF↓, 1,   BDNF↑, 5,   GABA↑, 2,   MAOA↓, 1,   NGF↑, 1,   tau↓, 5,   p‑tau↓, 6,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   Aβ↓, 14,   BACE/β-secretase↓, 5,   NLRP3↓, 7,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 23,   BioAv↑, 40,   BioAv⇅, 2,   BioAv↝, 11,   BioEnh↑, 3,   Dose↑, 4,   Dose↝, 16,   eff↓, 1,   eff↑, 13,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 7,   MRP1/ABCC1↓, 1,   P450↓, 2,   selectivity↑, 2,   Synergy↑, 59,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALP↓, 2,   AST↓, 10,   BloodF↑, 2,   BMD↑, 2,   BMPs↑, 1,   BP↓, 6,   BP↝, 1,   Calcium↑, 1,   creat↓, 1,   CRP↓, 6,   GutMicro↑, 11,   Hcy/homoC↝, 1,   hs-CRP↓, 1,   IL6↓, 28,   LDH↓, 2,   Mag↑, 1,   MUC19↓, 1,   PSA↓, 1,   RAGE↓, 1,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 4,   AntiArt↑, 2,   AntiCan↑, 5,   AntiDiabetic↑, 11,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP↓, 1,   cardioP↑, 24,   CardioT↓, 1,   chemoP↑, 9,   chemoPv↑, 4,   ChemoSideEff↓, 1,   cognitive↑, 20,   cognitive↝, 1,   hepatoP↑, 17,   memory↑, 16,   Mood↑, 1,   motorD↑, 3,   neuroP↓, 1,   neuroP↑, 45,   Obesity↓, 4,   Pain↓, 3,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 8,   Risk↓, 4,   Strength↑, 1,   toxicity↓, 21,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 6,   toxicity∅, 5,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 2,   AntiViral↑, 4,   Bacteria↓, 11,   Diar↓, 1,   IRF3↓, 1,  
Total Targets: 319

Scientific Paper Hit Count for: Synergy, Synergy
22 Curcumin
13 Vitamin C (Ascorbic Acid)
13 Quercetin
12 Sulforaphane (mainly Broccoli)
12 Chrysin
12 Dichloroacetate
10 Metformin
10 EGCG (Epigallocatechin Gallate)
9 Resveratrol
8 Silver-NanoParticles
8 Ashwagandha(Withaferin A)
8 Lycopene
8 Fisetin
7 Chemotherapy
7 Artemisinin
7 Atorvastatin
7 Berberine
6 Magnetic Fields
6 Vitamin K2
6 Silymarin (Milk Thistle) silibinin
6 Bicarbonate(Sodium)
6 Thymoquinone
5 Radiotherapy/Radiation
5 Hyperthermia
5 Apigenin (mainly Parsley)
5 Melatonin
5 Dipyridamole
5 immunotherapy
5 diet FMD Fasting Mimicking Diet
5 Formononetin
5 Gambogic Acid
5 Rosmarinic acid
4 3-bromopyruvate
4 Alpha-Lipoic-Acid
4 Gemcitabine (Gemzar)
4 Propolis -bee glue
4 Capsaicin
4 Carvacrol
4 salinomycin
4 Dandelion Root
4 Disulfiram
4 Fenbendazole
4 Phenethyl isothiocyanate
4 Piperlongumine
4 Urolithin
4 VitK3,menadione
3 1,8-Cineole
3 Auranofin
3 Photodynamic Therapy
3 Astaxanthin
3 beta-carotene(VitA)
3 borneol
3 Caffeic acid
3 Carnosic acid
3 chitosan
3 Copper and Cu NanoParticles
3 Piperine
3 diet Methionine-Restricted Diet
3 Emodin
3 Hydrogen Gas
3 Selenium NanoParticles
2 2-DeoxyGlucose
2 cetuximab
2 Vitamin B12
2 Folic Acid, Vit B9
2 chemodynamic therapy
2 Allicin (mainly Garlic)
2 Andrographis
2 Aspirin
2 Baicalein
2 Biochanin A
2 Betulinic acid
2 Lutein
2 Zeaxanthin
2 Thymol-Thymus vulgaris
2 Sorafenib (brand name Nexavar)
2 Chlorogenic acid
2 5-fluorouracil
2 Citric Acid
2 Coenzyme Q10
2 Ellagic acid
2 Bortezomib
2 Docosahexaenoic Acid
2 Vitamin A, Retinoic Acid
2 erastin
2 Exercise
2 Ferulic acid
2 ferumoxytol
2 Fucoidan
2 Gallic acid
2 Cisplatin
2 doxorubicin
2 Genistein (soy isoflavone)
2 HydroxyCitric Acid
2 Spermidine
2 Honokiol
2 Lecithin
2 Niclosamide (Niclocide)
2 Selenite (Sodium)
2 Terpinen-4-ol / Tea Tree Oil
2 Vitamin D3
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 EMF
1 SonoDynamic Therapy UltraSound
1 Trichostatin A
1 Anti-oxidants
1 5-Aminolevulinic acid
1 almonertinib
1 D-limonene
1 Huperzine A/Huperzia serrata
1 Bufalin/Huachansu
1 Bifidobacterium
1 Boron
1 Boswellia (frankincense)
1 Butyrate
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Beta‐Lapachone
1 Chlorophyllin
1 Rutin
1 Cinnamon
1 Hydroxycinnamic-acid
1 Selenium
1 Cucurbitacin
1 Dasatinib/Phyrago
1 Diclofenac
1 diet Ketogenic
1 Oxygen, Hyperbaric
1 Mistletoe/Viscum album Extracts
1 Echinacea
1 Electrical Pulses
1 Eugenol
1 temozolomide
1 Geldanamycin
1 Radicicol/monorden
1 Arsenic trioxide
1 olaparib/LYNPARZA
1 verapamil
1 hydroxychloroquine
1 Calorie Restriction Mimetics
1 Juglone
1 Linalool
1 Luteolin
1 Matrine
1 methotrexate
1 Magnetic Field Rotating
1 Magnesium
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Naringin
1 Phenylbutyrate
1 Paclitaxel/Taxol
1 Phosphatidylserine
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 Sulfasalazine
1 acetaminophen
1 acetazolamide
1 Shikonin
1 statins
1 triptolide
1 Turmerones
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1849  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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