MMP2 Cancer Research Results

MMP2, metalloproteinase-2: Click to Expand ⟱
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Matrix metalloproteinase-2 (MMP-2) is an enzyme that plays a significant role in the degradation of extracellular matrix components, which is crucial for various physiological processes, including tissue remodeling, wound healing, and angiogenesis.
Elevated levels of MMP-2 have been associated with poor prognosis in various cancers, including breast, lung, and colorectal cancers.
MMP2 and MMP9: two enzymes are critical to tumor invasion.
Scientific Papers found: Click to Expand⟱
6201- Cuc,    Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities
- Review, Var, NA - Review, AD, NA
*toxicity↑, *antiOx↑, *Inflam↓, *NLRP3↓, *NF-kB↓, *neuroP↑, *memory↑, *GABA↑, *cardioP↑, AntiTum↑, p‑FAK↓, ROS↑, TumMeta↑, TumCP↓, Apoptosis↑, P53↑, P21↑, TumCCA↑, p27/CDKN1B↑, CDK4↓, CDK2↓, cycD1/CCND1↓, cycE/CCNE↓, STAT3↓, ChemoSen↑, MMP2↓, MMP9↓, VEGF↓, TumCMig↓, angioG↓, NOTCH↓, EMT↓, toxicity↑, BioAv↑, EPR↑,
2688- CUR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Var, NA - Review, AD, NA
*ROS↓, *SOD↑, p16↑, JAK2↓, STAT3↓, CXCL12↓, IL6↓, MMP2↓, MMP9↓, TGF-β↓, α-SMA↓, LAMs↓, DNAdam↑, *memory↑, *cognitive↑, *Inflam↓, *antiOx↑, *NO↑, *MDA↓, *ROS↓, DNMT1↓, ROS↑, Casp3↑, Apoptosis↑, miR-21↓, LC3II↓, ChemoSen↑, NF-kB↓, CSCs↓, Nanog↓, OCT4↓, SOX2↓, Synergy↑, Sp1/3/4↓, miR-27a-3p↓, ZBTB10↑, SOX9?, ChemoSen↑, VEGF↓, XIAP↓, Bcl-2↓, cycD1/CCND1↓, BioAv↑, Hif1a↓, EMT↓, BioAv↓, PTEN↑, VEGF↓, Akt↑, EZH2↓, NOTCH1↓, TP53↑, NQO1↑, HO-1↑,
2974- CUR,    Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT15 - in-vitro, CRC, COLO205 - in-vitro, CRC, SW-620 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumCG↓, TumMeta↓, Sp1/3/4↓, HDAC4↓, FAK↓, CD24↓, E-cadherin↑, EMT↓, TumCP↓, NF-kB↓, AP-1↝, STAT3↓, P53?, β-catenin/ZEB1↓, NOTCH1↝, Hif1a↝, PPARα↝, Rho↓, MMP2↓, MMP9↓,
464- CUR,    Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p/STAT3 axis
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, TPC-1
TumCI↓, TumCI↓, MMP2↓, MMP9↓, EMT↓, STAT3↓, miR-301a-3p↓, STAT↓, N-cadherin↓, Vim↓, Fibronectin↓, p‑JAK↓, p‑JAK2↓, p‑JAK3↓, p‑STAT1↓, p‑STAT2↓, E-cadherin↑,
155- CUR,    Osteopontin and MMP9: Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate Cancer Cells
- in-vitro, Pca, PC3
p‑ERK↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, angioS↑,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2/PTGS2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
170- CUR,    Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis
- vitro+vivo, Pca, PC3
TRAILR↑, BAX↑, P21↑, p27/CDKN1B↑, NF-kB↓, cycD1/CCND1↓, VEGF↓, uPA↓, MMP2↓, MMP9↓, Bcl-2↓, Bcl-xL↓,
181- CUR,    The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo
- vitro+vivo, Pca, DU145
MMP2↓, MMP9↓, TumCP↓, TumCI↓,
1418- CUR,    Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
- Review, Arthritis, NA
*COX2/PTGS2↓, *Inflam↓, *5LO↓, *NO↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↑, *IL6↓, *IL8↓, *IL12↓, *MCP1/CCL2↓, *PGE2↓, *MMP2↓, *MMP3↓, *MMP9↓, *NLRP3↓, *ROS↓,
6238- CUSP9,    A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3
- Trial, GBM, NA
toxicity↓, TrxR↓, ROS↓, TumCI↓, TumCMig↓, TumCA↓, MMP2↓, MMP9↓, COX2/PTGS2↓, ALDH↓, TumAuto↑, P-gp/ABCB1↓, eff↑,
6237- CUSP9,    CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide
- in-vitro, GBM, NA
PI3K↓, Akt↓, ROS↑, NF-kB↓, TNF-α↓, TLR2↓, other↓, TrxR↓, STAT3↓, MMPs↓, COX1↓, COX2/PTGS2↓, CA↓, ALDH↓, P-gp/ABCB1↓, HH↓, 5LO↓, mTOR↓, CycD3↓, Proteasome↓, other↓, MMP2↓, MMP9↓, ALDH↓, Copper↓,
6246- Cyc,    Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti-proliferative, anti-invasive and anti-estrogenic potency in human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
HH↓, TumCP↓, TumCCA↓, TumCI↓, NF-kB↓, MMP2↓, MMP9↓, ERα/ESR1↓, cycD1/CCND1↓,
6255- Cyste,    Cysteamine Suppresses Cancer Cell Invasion and Migration in Glioblastoma through Inhibition of Matrix Metalloproteinase Activity
- in-vitro, GBM, NA
MMPs↓, MMP2↓, MMP9↓, MMP14↓, TumCI↓, TumCMig↓, Dose↓,
6676- Deg,    Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry
- Review, Var, NA
TumCP↓, Apoptosis↑, NF-kB↓, Wnt↓, TumCCA↑, TumMeta↑, antiOx↑, Inflam↓, angioG↓, Half-Life↑, MMP2↓, MMP9↓, Casp9↑, Casp3↑, EMT↓, PTEN↑, ChemoSen↑, toxicity↑, *BBB↑,
19- Deg,    Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓, TumCG↓, Apoptosis↑, TumCMig↓, TumCI↓,
8847- DIM,    Studies on the mode of action of synthetic diindolylmethane derivatives against triple negative breast cancer cells
- in-vitro, BC, NA
eff?, MMP2↓, MMP9↓, RAS↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, EGFR↓,
8845- DIM,  I3C,    3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways
- Review, Var, NA
*BioAv↝, *BioAv↓, *BioAv↓, *AntiAg↑, *ROS↓, *AntiThr↑, *Stroke↓, *CYP1A1↑, *CYP1A2↑, *GSTs↑, *NQO1↑, AntiTum↑, AntiCan↑, TumAuto↓, Let-7↑, miR-34a↑, TumCMig↓, Apoptosis↑, MMP↓, mtDam↑, ROS↑, TumCCA↑, other↝, PSA↓, Dose↝, MMP2↓, MMP3↓, MMP9↓, EGFR↓, RAS↓, PI3K↓, Akt↓, mTOR↓, CDK4↓, cycD1/CCND1↓, P21↑, MDM2↓, TumCP↓, NF-kB↓, RANKL↓, PUMA↓, Wnt↓, MTA2↓, EZH2↓, AhR↓, PTEN↑, NOTCH1↓, IRAK1↓, p27/CDKN1B↓, CDKN1C/p57↓, CDC25↓, EGFR↓, Zeb1↓, FOXM1↓, SOX4↓, E-cadherin↑, uPA↓, uPAR↓,
8841- DIM,    3,3'-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis
- in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Casp↑, EMT↓, UPR↓, Ca+2↑, ROS↑, MMP↓, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, IRE1↑, PERK↑, PDI↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Slug↓, Snail↓, chemoPv↑,
6273- DL,    D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways
- in-vitro, Colon, Caco-2 - in-vitro, Nor, HEK293 - in-vitro, Colon, HCT116
ROS↑, antiOx↓, GSH↓, Casp3↑, BAX↑, P53↑, LDH↑, TNF-α↑, IL1β↑, MMP2↓, MMP9↓, Ki-67↓, Bcl-2↓, selectivity↑,
6348- DRE,    New prospects in oncotherapy: bioactive compounds from Taraxacum officinale
- Review, Var, NA
Ingr↝, TumCP↓, toxicity↓, *AntiDiabetic↑, *antiOx↑, *hepatoP↑, *diuretic↑, *Inflam↓, *neuroP↑, *Imm↑, eff↑, Apoptosis↑, tumCV↓, selectivity↑, TumCMig↓, EMT↓, MMP2↓, MMP9↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, JNK↓, ERK↓,
6350- DRE,    Tracking Evidences of Dandelion for the Treatment of Cancer: From Chemical Composition, Bioactivity, Signaling Pathways in Cancer Cells to Perspective Study
- Review, Var, NA
AntiCan↑, *Bacteria↓, *Inflam↓, *antiOx↑, TumCCA↑, Apoptosis↑, MOMP↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, MMP↓, Bcl-2↓, TumCMig↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓, TumAuto↑, mTOR↓, 4E-BP1↓, Glycolysis↓, angioG↓,
6317- DRE,    The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells
- in-vitro, Melanoma, A375
Apoptosis↑, selectivity↑, Casp8↑, mt-ROS↑, eff↑, *toxicity↓, Diff↑, TumCP↓, chemoPv↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *RNS↓, TumCI↓, MMP2↓, MMP9↓, p‑Src↓, p‑FAK↓,
6365- DRE,    AN OVERVIEW OF THERAPEUTIC POTENTIALS OF TARAXACUM OFFICINALE (DANDELION): A TRADITIONALLY VALUABLE HERB WITH A REACH HISTORICAL BACKGROUND
- Review, Var, NA
*Inflam↓, *AntiTum↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *diuretic↑, *RenoP↑, *hepatoP↑, *neuroP↑, AntiTum↑, TNF-α↑, IL1β↑, Apoptosis↑, MMP2↓, MMP9↑, Synergy↑, Diff↑, *ROS↓, *HO-1↑, *NRF2↑, *lipid-P↓,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, Synergy↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
4832- EA,    Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid
- Review, Var, NA
*antiOx↑, *AntiCan↑, TumCMig↓, angioG↓, ChemoSen↑, RadioS↑, *chemoP↑, *BioAv↓, eff↓, selectivity↑, MMP2↓, MMP9↓, VEGF↓, TumCCA↑, Apoptosis↑, ROS↑, BioAv↑,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2/PTGS2↓, Hif1a↓, VEGF↓, VEGFR2/KDR/Flk1↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2/PTGS2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
7220- EGb 761,    Ginkgo Biloba Extract Inhibits Metastasis and ERK/Nuclear Factor kappa B (NF-κB) Signaling Pathway in Gastric Cancer
- vitro+vivo, GC, SGC-7901
TumCP↓, TumCMig↓, TumCI↓, p‑ERK↓, NF-kB↓, MMP2↓, eff↑, TumCG↓, TumMeta↓, Dose↝, TumVol↓,
3233- EGCG,    Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways
- in-vitro, Cerv, HeLa
DNMTs↓, DNMT1↓, DNMT3A↓, HDAC2↓, HDAC3↓, HDAC4↓, EZH2↓, PI3K↓, Wnt↓, MAPK↓, hTERT/TERT↓, MMP2↓, MMP7↓, IL6↓, MDM2↓, MMP-10↓, TP53↑, PTEN↑,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, Var, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
3211- EGCG,    Antioxidation Function of EGCG by Activating Nrf2/HO-1 Pathway in Mice with Coronary Heart Disease
- in-vivo, CardioV, NA
*cardioP↑, *VEGF↓, *MMP2↓, *SOD↑, *ROS↓, *HO-1↑, *NQO1↑, *NRF2↑,
3212- EGCG,    EGCG maintained Nrf2-mediated redox homeostasis and minimized etoposide resistance in lung cancer cells
- in-vitro, Lung, A549 - in-vivo, Lung, NCIH23
NRF2⇅, ChemoSen↑, SOD1↑, SOD1↓, MMP2⇅, MMP9⇅,
2992- EGCG,    Effects of Epigallocatechin-3-Gallate on Matrix Metalloproteinases in Terms of Its Anticancer Activity
- Review, Var, NA
AP-1↓, Sp1/3/4↓, NF-kB↓, ERK↓, P-gp/ABCB1↓, HSP27↓, β-catenin/ZEB1↓, MMPs↓, TNF-α↓, IL1β↓, MMP2↓,
639- EGCG,    Immunomodulatory Effects of Green Tea Catechins and Their Ring Fission Metabolites in a Tumor Microenvironment Perspective
- Review, Var, NA
TIMP3↑, MMP2↓, MMP9↓,
1322- EMD,    The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers
- Review, Var, NA
Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, Synergy↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, Synergy↑, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, Synergy↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?, *antiAll↑,
6823- EMD,    Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
- Review, Var, NA
AntiCan↑, *antiOx↑, *chemoP↑, *Inflam↓, TumCP↓, TumMeta↓, TumCCA↑, MAPK↑, BAX↑, Casp↑, ROS↑, *BioAv↓, other↝, TumCI↓, EMT↓, TumCG↑, Apoptosis↑, TumCP↑, MMP2↓, Casp3↑, ChemoSen↑, PI3K↓, Akt↓, Cyt‑c↑, cl‑PARP↑, MMP↓, Warburg↓, HK2↓, PKM2↓, LDHA↓, mtDam↑, Apoptosis↑, N-cadherin↓, Vim↓, E-cadherin↑, eff↑, eff↑, eff↑, toxicity↝, toxicity↑,
6580- EU,    Eurycomanone Blocks TGF-β1-Induced Epithelial-to-Mesenchymal Transition, Migration, and Invasion Pathways in Human Non-Small Cell Lung Cancer Cells by Targeting Smad and Non-Smad Signaling
- in-vitro, Lung, A549 - in-vitro, Lung, Calu-1
TumCMig↓, MMP2↓, EMT↓, E-cadherin↑, Akt↓, N-cadherin↓, TGF-β↓, Smad1↓,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *CompStab↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1 / PDPK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6338- Eug,    Tumor suppressive roles of eugenol in human lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCMig↓, TumCI↓, Akt↓, MMP2↓, *lipid-P↓, *COX2/PTGS2↓, *ROS↓, PI3K↓,
6325- Eug,    Anticancer Properties of Eugenol: A Review
- Review, Var, NA
*antiOx↑, *AntiCan↑, *Inflam↓, TumCD↑, TumCCA↑, TumCMig↓, TumMeta↓, angioG↓, ChemoSen↑, chemoP↑, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *Bacteria↓, *ROS↓, *IL6↓, *COX2/PTGS2↓, *TNF-α↓, *lipid-P↓, *SOD1↑, *Catalase↑, *GPx1↑, *GSTs↑, ROS↑, MMP↓, Apoptosis↑, COX2/PTGS2↓, TumCCA↑, E2Fs↓, PI3K↓, Akt↓, MMPs↓, CSCs↓, OCT4↓, CD44↓, EpCAM↓, NOTCH1↓, TumVol↓, Casp3↑, P53↑, cl‑PARP↑, MMP2↓, MMP9↓, TIMP1↑, ALDH↓, NF-kB↓, *toxicity↓,
6332- Eug,    Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
TumCP↓, MMP2↓, MMP9↓, TIMP1↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑,
6331- Eug,    Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
- in-vitro, BC, MDA-MB-231
Apoptosis↑, TumAuto↑, TumCP↓, Akt↑, FOXO3↑, P21↑, p27/CDKN1B↑, Casp3↑, Casp9↑, LC3s↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, E2Fs↓, survivin↓, BAX↑, Cyt‑c↑,
6330- Eug,    Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement
- Review, Var, NA
TumCD↑, TumCCA↑, AntiCan↑, Apoptosis↑, angioG↓, TumCI↓, TumMeta↓, ChemoSen↑, ALDH↓, NF-kB↓, IL6↓, IL8↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Snail↓, E-cadherin↑, SOX2↓, ROS↑, PCNA↓, MMP1↓, Cyt‑c↑, LDH↑, CSCs↓, OCT4↓, NOTCH1↓, EpCAM↓, CD44↓, HER2/EBBR2↓, VEGF↓, TIMP2↑, eff↑, Ca+2↑, TumVol↓, DNAdam↑, GSH↓, H2O2↑, lipid-P↑,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
7513- FA,    Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP
- in-vitro, Thyroid, NA
cycD1/CCND1↓, URGCP/URG4↓, CDK4↓, CDK6↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, BAX↑, Casp3↑, Casp9↑, TIMP1↑, TumCI↓, TumCMig↓, TumCCA↑, Apoptosis↑,
7510- FA,    Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability
- in-vitro, Lung, H1299
*antiOx↑, ROS↑, H2O2↑, TumCP↓, TumCMig↓, MMP2↓, MMP9↓,

Showing Research Papers: 101 to 150 of 349
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 349

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 10,   Catalase↓, 8,   Catalase↑, 2,   Copper↓, 1,   Copper↑, 1,   ENOX2↓, 1,   frataxin↑, 1,   GPx↓, 3,   GPx↑, 2,   GPx4↓, 4,   GSH↓, 21,   GSH↑, 4,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 2,   GSTs↑, 2,   H2O2↓, 2,   H2O2↑, 6,   HO-1↓, 11,   HO-1↑, 10,   HO-2↓, 1,   Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 10,   MDA↓, 4,   MDA↑, 2,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 2,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 11,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   ROS?, 2,   ROS↓, 23,   ROS↑, 150,   ROS⇅, 6,   ROS↝, 2,   i-ROS↑, 2,   mt-ROS↑, 2,   SOD↓, 11,   SOD↑, 3,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 3,   SOD2↑, 2,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 5,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   Tf↓, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   CDC2↓, 8,   CDC25↓, 9,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 4,   ETC↓, 2,   mitResp↓, 1,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 7,   OCR↓, 4,   OCR↑, 1,   mt-OXPHOS↓, 1,   PDH↝, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 4,   ACC↑, 2,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 19,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 11,   CAIX/CA9↑, 1,   ECAR↓, 3,   ECAR↝, 1,   FABP4↑, 1,   FASN↓, 4,   GLO-I↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 6,   GlutMet↓, 2,   Glycolysis↓, 18,   GSK‐3β↓, 10,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 4,   HK1↓, 1,   HK2↓, 8,   lactateProd↓, 9,   LDHA↓, 6,   LDL↓, 2,   NADPH↓, 3,   NADPH↑, 2,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 1,   PIP3↑, 1,   PKM2↓, 8,   PKM2↑, 1,   PLA2↓, 1,   p‑S6↓, 1,   SIRT1↓, 7,   SIRT1↑, 7,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 9,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 123,   Apoptosis↝, 1,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 4,   BAD↑, 7,   Bak↑, 7,   BAX↓, 2,   BAX↑, 80,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 20,   Bcl-2↓, 92,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 25,   Bcl-xL↝, 1,   BID↓, 2,   BID↑, 2,   BIM↑, 4,   BNIP3↑, 2,   Casp↑, 23,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 2,   Casp2↑, 1,   Casp3↓, 4,   Casp3↑, 100,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↑, 15,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 28,   Casp8∅, 1,   cl‑Casp8↑, 4,   Casp9↓, 1,   Casp9↑, 65,   cl‑Casp9↑, 9,   proCasp9↓, 1,   CellShr↑, 2,   cFLIP↓, 5,   Cyt‑c↓, 1,   Cyt‑c↑, 62,   Cyt‑c↝, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 12,   DR5↑, 21,   Endon↑, 2,   FADD↑, 3,   Fas?, 1,   Fas↓, 1,   Fas↑, 20,   FasL↓, 1,   FasL↑, 7,   FasL⇅, 1,   Ferroptosis↑, 5,   GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 8,   IAP2/BIRC3↓, 1,   iNOS↓, 14,   Mcl-1?, 1,   Mcl-1↓, 21,   MDM2↓, 9,   MDM2↑, 1,   p‑MDM2↓, 2,   MOMP↑, 3,   Necroptosis↑, 1,   NOXA↑, 3,   oncosis↑, 1,   p38↓, 9,   p38↑, 8,   p‑p38↓, 5,   p‑p38↑, 3,   p‑p38↝, 1,   PUMA↓, 1,   PUMA↑, 5,   Pyro↑, 2,   survivin↓, 40,   TNFR 1↑, 3,   TRAIL↑, 3,   TRAILR↑, 3,   TumCD↑, 9,   XIAP↓, 22,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 115,   Akt↑, 3,   Akt↝, 1,   p‑Akt↓, 38,   AKT1↓, 1,   CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 2,   cSrc↓, 1,   EGFR↓, 28,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 3,   ERK↓, 42,   ERK↑, 6,   ERK↝, 2,   p‑ERK↓, 20,   p‑ERK↝, 1,   FGFR1↓, 3,   FGFR2↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 12,   HGF/c-Met↓, 3,   Hippo↑, 1,   IGF-1R↓, 4,   IGFR↓, 2,   IKKα↓, 9,   IKKα↝, 1,   p‑IKKα↓, 2,   p‑IκB↓, 3,   JAK↓, 6,   p‑JAK↓, 1,   JAK1↓, 3,   JAK1↑, 1,   p‑JAK1↓, 1,   JAK2↓, 14,   p‑JAK2↓, 2,   JAK3↓, 1,   p‑JAK3↓, 1,   JNK↓, 7,   JNK↑, 10,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 2,   p‑JNK↝, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 31,   MAPK↑, 10,   MAPK↝, 1,   p‑MAPK↓, 2,   MARK4↓, 1,   MEK↓, 8,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 60,   mTOR↝, 2,   p‑mTOR↓, 10,   mTORC2↓, 2,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 2,   p‑P70S6K↓, 1,   P90RSK↓, 2,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 94,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 7,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 2,   PKA↓, 1,   PKCδ↓, 11,   PTEN↓, 1,   PTEN↑, 24,   PTEN↝, 1,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 12,   RCC1↓, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 9,   p‑Src↓, 2,   STAT↓, 4,   p‑STAT2↓, 1,   STAT3↓, 71,   STAT3↑, 2,   p‑STAT3↓, 9,   p‑STAT3↑, 4,   STAT4↓, 2,   STAT5↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 4,   CBP↓, 1,   cJun↓, 8,   cJun↑, 1,   cMyc↓, 29,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 4,   DNMT3A↓, 2,   DNMTs↓, 7,   EZH2↓, 7,   FOXM1↓, 4,   FOXO↑, 4,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 8,   FOXO3↝, 1,   FOXO4↓, 2,   FOXO4↑, 1,   H3↓, 2,   H3↑, 1,   ac‑H3↓, 1,   ac‑H3↑, 2,   H3K27ac↓, 1,   H4↓, 1,   ac‑H4↓, 1,   ac‑H4↑, 2,   HATs↓, 5,   HATs↑, 1,   HDAC↓, 17,   HDAC1↓, 4,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 4,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 3,   HOXB-AS1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   METTL7A↑, 1,   miR-106b↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-126↓, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 3,   miR-155↑, 1,   miR-17↓, 1,   miR-182-5p↓, 1,   miR-194↑, 1,   miR-195↑, 1,   miR-200b↑, 2,   miR-200c↓, 1,   miR-203↑, 1,   miR-21↓, 8,   miR-21↑, 2,   miR-210↑, 1,   miR-22↑, 1,   miR-221↓, 1,   miR-224↓, 2,   miR-25-5p↑, 1,   miR-27a-3p↓, 1,   miR-27a-3p↑, 1,   miR-29b↑, 1,   miR-301a-3p↓, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 4,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 2,   miR-592↑, 1,   MTA2↓, 1,   Myc↓, 4,   n-MYC↓, 2,   NDRG1↑, 1,   OCT4↓, 13,   other↓, 4,   other↑, 1,   other↝, 5,   other∅, 1,   PAX2↓, 1,   PhotoS↑, 1,   RASSF1A↑, 1,   SOX2↓, 9,   SOX4↓, 2,   SOX9?, 1,   SOX9↓, 1,   SOX9↑, 1,   TCF-4↓, 1,   tumCV↓, 35,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 16,   eIF2α↓, 1,   p‑eIF2α↑, 3,   ER Stress↓, 1,   ER Stress↑, 25,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 9,   GRP78/BiP↝, 1,   HSF1↓, 1,   HSP27↓, 5,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↝, 1,   HSP90↓, 6,   HSPs↓, 1,   IRE1↑, 4,   PDI↑, 1,   PERK↑, 4,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↓, 1,   UPR↑, 5,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 9,   CTSB↓, 2,   CTSD↓, 2,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3A↑, 1,   LC3B↓, 1,   LC3B-II↑, 4,   LC3II↓, 2,   LC3II↑, 8,   LC3s↑, 1,   p62↓, 6,   TumAuto↓, 1,   TumAuto↑, 27,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 42,   DNArepair↓, 4,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC3↑, 1,   HR↓, 1,   hTERT/TERT↓, 11,   MGMT↓, 1,   p16↑, 5,   P53?, 2,   P53↓, 2,   P53↑, 57,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 2,   PARP↑, 19,   cl‑PARP↑, 41,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 26,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 13,   TOP1↓, 5,   TOP2↓, 4,   TOP2↑, 2,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 7,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 12,   CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 35,   CDK2↑, 2,   CDK4↓, 43,   CDK4↑, 1,   CDK4/6↓, 2,   CDK6↓, 18,   CDK6↑, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 3,   p‑CHK1↑, 2,   Chk2↓, 2,   p‑Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 2,   Cyc↝, 1,   cycA1/CCNA1↓, 9,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 16,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 67,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 1,   CycD3↓, 2,   cycE/CCNE↓, 18,   cycE1↓, 1,   E2Fs↓, 6,   GADD45A↓, 1,   Ki-67↓, 17,   MAD↓, 1,   P21↓, 3,   P21↑, 43,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 24,   pRB↑, 1,   p‑pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   Securin↓, 2,   TumCCA?, 1,   TumCCA↓, 8,   TumCCA↑, 118,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH↓, 6,   ALDH1A1↓, 2,   BMP2↓, 2,   BMPs↑, 1,   CD133↓, 8,   CD24↓, 3,   CD34↓, 1,   cFos↓, 7,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 34,   Diff↓, 2,   Diff↑, 2,   EIF4E↓, 1,   FGF↓, 3,   FGF↑, 1,   Gli↓, 2,   Gli1↓, 7,   HH↓, 7,   IGF-1↓, 6,   IGF-2↓, 1,   IGFBP3↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Ki-67↓, 17,   Let-7↑, 4,   LRP6↓, 1,   p‑LRP6↓, 1,   mTORC1↓, 3,   p‑mTORC1↓, 1,   Nanog↓, 9,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 18,   NOTCH1↓, 14,   NOTCH1↑, 1,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH3↓, 1,   p300↓, 2,   Piezo1↑, 1,   PTCH1↓, 2,   Shh↓, 8,   Smo↓, 3,   p‑STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG↓, 51,   TumCG↑, 3,   TumCP?, 1,   TumCP↓, 98,   TumCP↑, 4,   tyrosinase↓, 1,   URGCP/URG4↓, 1,   Wnt↓, 38,   Wnt/(β-catenin)↓, 5,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 11,   AP-1↝, 2,   ATPase↓, 1,   AXL↓, 2,   CA↓, 2,   Ca+2↑, 30,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal9↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 2,   Cdc42↑, 1,   p‑Cofilin↑, 2,   COL1↓, 3,   COL1A1↓, 1,   COL3A1↓, 2,   DLC1↑, 1,   E-cadherin↓, 14,   E-cadherin↑, 70,   EMT↓, 98,   EMT↑, 3,   EpCAM↓, 3,   F-actin↓, 3,   FAK↓, 15,   FAK↑, 1,   p‑FAK↓, 3,   Fibronectin↓, 10,   GIT1↓, 1,   GLI2↓, 2,   IQGAP3↓, 1,   ITGA1∅, 1,   ITGA5↓, 1,   ITGA5∅, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB1∅, 1,   ITGB3↓, 1,   ITGB3∅, 1,   ITGB4∅, 1,   KRAS↓, 1,   LAMs↓, 1,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 3,   MMP1↓, 10,   MMP13↓, 5,   MMP14↓, 1,   MMP16↓, 3,   MMP2?, 2,   MMP2↓, 322,   MMP2↑, 3,   MMP2⇅, 1,   MMP2↝, 2,   MMP2∅, 1,   proMMP2↓, 1,   MMP3↓, 11,   MMP7↓, 15,   MMP7∅, 1,   MMP9?, 2,   MMP9↓, 263,   MMP9↑, 3,   MMP9⇅, 1,   MMP9↝, 1,   MMP9∅, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 29,   MTA1↓, 2,   N-cadherin↓, 48,   NCAM↓, 1,   NCAM↑, 1,   PAK1↓, 2,   pax↓, 1,   PDGF↓, 7,   Rac1↓, 3,   RECK↑, 1,   Rho↓, 6,   Rho↑, 1,   ROCK1↓, 4,   ROCK1↑, 2,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 20,   Smad1↓, 2,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 3,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↓, 2,   Snail?, 1,   Snail↓, 40,   Snail↑, 1,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 18,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 5,   TIMP1↑, 21,   TIMP2↓, 7,   TIMP2↑, 18,   TIMP3↑, 2,   TSP-1↑, 4,   TumCA↓, 5,   TumCA↑, 1,   TumCI↓, 123,   TumCI↑, 2,   TumCMig↓, 118,   TumCMig↑, 1,   TumMeta↓, 69,   TumMeta↑, 7,   TumPF↓, 1,   Twist↓, 26,   Twist↑, 1,   Tyro3↓, 1,   uPA↓, 34,   uPAR↓, 6,   Vim?, 1,   Vim↓, 53,   Vim↑, 1,   Zeb1↓, 18,   ZEB2↓, 1,   ZEB2↑, 1,   α-SMA↓, 5,   α-SMA↑, 1,   β-catenin/ZEB1↓, 44,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 74,   angioG↑, 1,   angioS↑, 1,   CD31/PECAM-1↓, 2,   ECM/TCF↓, 1,   Endoglin↑, 1,   eNOS↓, 2,   HIF-1↓, 7,   Hif1a↓, 50,   Hif1a↑, 1,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 8,   NO↑, 1,   PHDs↓, 1,   TXA2↓, 1,   VCAM-1↓, 3,   VEGF↓, 115,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 5,   VEGFR2/KDR/Flk1↓, 16,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↓, 3,   CLDN2↓, 1,   EPR↑, 5,   GLUT1↓, 7,   GLUT1↑, 1,   GLUT3↑, 1,   MMP↓, 76,   MMP↑, 1,   MMP∅, 1,   MPT↑, 4,   NHE1↓, 2,   TRPM7↓, 3,   TRPV1↑, 3,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 14,   CD59↑, 1,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2↓, 79,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 13,   DR4↑, 8,   FOXP3↓, 2,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 6,   IFN-γ↓, 5,   IFN-γ↑, 2,   Igs↑, 1,   IL1↓, 6,   IL1↑, 1,   IL10↓, 7,   IL10↑, 2,   IL12↓, 3,   IL12↑, 1,   IL18↓, 2,   IL1α↓, 2,   IL1β↓, 18,   IL1β↑, 2,   IL2↓, 3,   IL2↑, 4,   IL4↑, 2,   IL6↓, 47,   IL6↑, 1,   IL6↝, 1,   IL8↓, 12,   IL8↑, 1,   Imm↑, 2,   Imm↝, 3,   Inflam↓, 19,   IRAK1↓, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 6,   MCT1↓, 1,   MIP-1β↑, 1,   MIP2↓, 2,   mPGES-1↓, 2,   NF-kB?, 1,   NF-kB↓, 128,   NF-kB↑, 3,   NF-kB↝, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 3,   p50↓, 3,   p65↓, 13,   p‑p65↓, 4,   PD-1↓, 3,   PD-L1↓, 8,   PD-L1↑, 1,   PGE2↓, 24,   PSA↓, 4,   PSA↝, 1,   RAGE↓, 2,   SOCS-3↓, 1,   T-Cell↑, 1,   TCF↑, 1,   Th1 response↑, 3,   Th17↑, 1,   TLR2↓, 2,   TLR4↓, 4,   TNF-α↓, 34,   TNF-α↑, 6,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,   WFDC10A↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 1,   AR↓, 9,   AR↑, 1,   AR↝, 1,   ER-α36↓, 3,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   PPARα↓, 2,   PPARα↑, 2,   PPARα↝, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 8,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B10↓, 1,   BioAv↓, 32,   BioAv↑, 30,   BioAv↝, 9,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 100,   ChemoSen∅, 1,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↓, 2,   Dose↑, 6,   Dose↝, 29,   Dose∅, 8,   eff?, 1,   eff↓, 13,   eff↑, 41,   eff⇅, 1,   eff↝, 11,   GSTA1↑, 2,   Half-Life↓, 8,   Half-Life↑, 2,   Half-Life↝, 4,   Half-Life∅, 1,   MDR1↓, 5,   MRP1/ABCC1↓, 3,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 19,   P450↓, 2,   RadioS↑, 35,   selectivity?, 1,   selectivity↑, 47,   Synergy?, 1,   Synergy↑, 68,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 6,   ALP↓, 2,   AR↓, 9,   AR↑, 1,   AR↝, 1,   ascitic↓, 1,   AST↓, 4,   BRCA1↓, 2,   BRCA1↑, 1,   CEA↓, 1,   CRP↓, 4,   E6↓, 2,   E7↓, 2,   EGFR↓, 28,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 3,   ERα/ESR1↓, 1,   EZH2↓, 7,   Ferritin↓, 1,   FOXM1↓, 4,   HER2/EBBR2↓, 12,   hTERT/TERT↓, 11,   IL6↓, 47,   IL6↑, 1,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 3,   LDH↑, 4,   Myc↓, 4,   NSE↓, 1,   PD-L1↓, 8,   PD-L1↑, 1,   PSA↓, 4,   PSA↝, 1,   RAGE↓, 2,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 33,   antiD↑, 1,   AntiDiabetic↑, 2,   antiNeop↑, 2,   AntiTum↑, 17,   cachexia↓, 3,   cardioP↑, 9,   chemoP?, 1,   chemoP↑, 20,   chemoPv↑, 14,   ChemoSideEff↓, 4,   cognitive↑, 2,   fatigue↓, 1,   hepatoP↑, 6,   neuroP↑, 5,   OS↑, 5,   Pain↓, 1,   Pin1↓, 1,   radioP↑, 6,   RenoP↑, 6,   Risk↓, 6,   toxicity↓, 8,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 12,   TumVol∅, 1,   TumW↓, 3,   TumW∅, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 1,   GutMicro↑, 2,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 6,  
Total Targets: 1004

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 4,   antiOx↑, 60,   Catalase↑, 20,   Copper↓, 1,   GPx↑, 17,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 21,   GSR↓, 1,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 10,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 2,   HO-1↑, 10,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 16,   MDA↓, 14,   MPO↓, 1,   NADH↓, 1,   NQO1↑, 3,   Nrf1↑, 1,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 23,   NRF2∅, 1,   Prx↑, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 71,   ROS∅, 1,   SOD↑, 27,   SOD1↑, 3,   SOD2↑, 3,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↓, 1,   ALAT↓, 8,   AMPK↓, 1,   AMPK↑, 1,   DGAT1↓, 1,   FABP4↓, 1,   FASN↓, 3,   GSK‐3β↓, 2,   LDL↓, 2,   SIRT1↑, 2,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

BAX↓, 4,   Casp3?, 1,   Casp3↓, 6,   Casp3↑, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   Ferroptosis↓, 1,   iNOS↓, 8,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 3,   p‑Akt↓, 1,   p‑Akt↑, 1,   CREB↑, 2,   ERK↓, 1,   ERK↑, 2,   IGF-1R↓, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 1,   p‑LIMK1↑, 1,   MAPK↓, 6,   MAPK↑, 1,   mTOR↑, 3,   PDGFR-BB↓, 1,   PI3K↑, 3,   PKCδ↑, 1,   PTEN↑, 1,   STAT3↓, 3,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   cJun↓, 2,   p‑cJun↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   HDAC3↓, 1,   HOTAIR↑, 1,   other↓, 3,   other↑, 2,   other↝, 3,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   p16↓, 1,   P53↓, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   E2Fs↑, 2,   Ki-67↓, 2,   P21↓, 1,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↓, 1,   FGF↑, 2,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 7,   AP-1↓, 3,   Ca+2?, 1,   Ca+2↓, 2,   Ca+2↝, 1,   p‑Cofilin↑, 1,   COL1↓, 1,   COL1↑, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   EMT↑, 1,   Fibronectin↓, 1,   LAMs↑, 1,   p‑MLC2/MYL9↑, 1,   MMP1↓, 1,   MMP2↓, 14,   MMP2↑, 6,   MMP3↓, 1,   MMP9↓, 7,   MMP9↑, 2,   MMPs↓, 1,   MYPT1 / PPP1R12A↑, 1,   p‑MYPT1 / PPP1R12A↑, 1,   PAI-1/SERPINE1↓, 1,   Rac1↑, 1,   Rho↓, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Smad1↑, 1,   Smad7↑, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 2,   TIMP1↑, 1,   TIMP2↑, 2,   TregCell↑, 1,   TumMeta↓, 1,   uPA↓, 1,   Vim↓, 1,   α-SMA↓, 4,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 3,   CD31/PECAM-1↓, 1,   eNOS↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 8,   NO↑, 2,   VCAM-1↓, 1,   VEGF↓, 4,   VEGF↑, 3,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 8,   CLDN1↝, 1,   CLDN5↓, 1,   GastroP↑, 2,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 1,   MMP↑, 4,   OCLN↓, 1,   TRPM7↓, 1,   ZO-1↓, 1,   ZO-1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 21,   Eos↓, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 1,   IL1↓, 3,   IL10↓, 1,   IL10↑, 4,   IL12↓, 2,   IL17↓, 2,   IL1β↓, 12,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 19,   IL6↑, 1,   IL8↓, 5,   Imm↑, 11,   Inflam↓, 62,   Inflam↑, 1,   MCP1/CCL2↓, 3,   MCP1/CCL2↑, 1,   NeuroI↓, 1,   NF-kB↓, 29,   NK cell↑, 1,   NLRP3↓, 2,   PGE2↓, 8,   PGE2↑, 1,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 2,   TLR4↓, 2,   TNF-α↓, 21,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 7,   AChE↑, 1,   BChE↓, 1,   BDNF↑, 4,   GABA↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 9,   BACE/β-secretase↓, 2,   tau↓, 2,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   Estro↓, 1,   PPARγ↓, 2,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 24,   BioAv↑, 24,   BioAv↝, 14,   BioEnh↑, 2,   CompStab↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose↑, 1,   Dose↝, 7,   eff↓, 1,   eff↑, 8,   Half-Life↓, 1,   Half-Life↝, 6,   Half-Life∅, 1,   P450↓, 3,   P450↑, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8,   ALP↓, 3,   AST↓, 11,   BMD↑, 1,   BP↓, 2,   BUN↓, 1,   creat↓, 1,   CRP↓, 1,   IL6↓, 19,   IL6↑, 1,   LDH↓, 2,   LDH↑, 1,   NOS2↓, 2,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   antiAll↑, 11,   AntiArt↑, 6,   AntiCan↓, 1,   AntiCan↑, 12,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 14,   AntiTum↓, 1,   AntiTum↑, 4,   cardioP↑, 28,   chemoP↑, 4,   chemoPv↑, 2,   cognitive↑, 7,   diuretic↑, 3,   hepatoP↓, 1,   hepatoP↑, 21,   Learn↑, 1,   memory↑, 11,   motorD↑, 3,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 44,   Obesity↓, 5,   Pain↓, 4,   radioP↑, 1,   RenoP↑, 3,   Stroke↓, 5,   toxicity↓, 21,   toxicity↑, 1,   toxicity↝, 5,   toxicity∅, 4,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↓, 1,   AntiFungal↑, 1,   AntiViral↑, 5,   Bacteria↓, 17,   Diar↓, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 3,  
Total Targets: 321

Scientific Paper Hit Count for: MMP2, metalloproteinase-2
14 Fisetin
14 Quercetin
10 Baicalein
10 Berberine
10 Matrine
10 Sulforaphane (mainly Broccoli)
8 Curcumin
8 Luteolin
8 Resveratrol
7 EGCG (Epigallocatechin Gallate)
6 Apigenin (mainly Parsley)
6 Magnetic Fields
6 Eugenol
6 Garcinol
6 Kaempferol
6 Lycopene
6 Rosmarinic acid
5 Artemisinin
5 Betulinic acid
5 Caffeic acid
5 Propolis -bee glue
5 Capsaicin
5 Dandelion Root
5 Ellagic acid
5 Thymoquinone
4 Carvacrol
4 Chrysin
4 Formononetin
4 Magnolol
4 Piperine
4 Silymarin (Milk Thistle) silibinin
3 Silver-NanoParticles
3 Ashwagandha(Withaferin A)
3 Boswellia (frankincense)
3 Hydroxycinnamic-acid
3 Diindolylmethane
3 Emodin
3 Ferulic acid
3 Fucoidan
3 Gambogic Acid
3 Honokiol
3 Naringin
3 Nimbolide
3 Phenethyl isothiocyanate
3 Pterostilbene
3 Selenite (Sodium)
3 Urolithin
3 Vitamin C (Ascorbic Acid)
2 Alpha-Lipoic-Acid
2 alpha Linolenic acid
2 Andrographis
2 Radiotherapy/Radiation
2 Astaxanthin
2 Baicalin
2 Berbamine
2 Brucea javanica
2 Boron
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Cinnamon
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 CUSP9
2 Deguelin
2 Indole-3-carbinol
2 Ginkgetin
2 Grapeseed extract
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 Hyperoside
2 mebendazole
2 Melatonin
2 Morin
2 Mushroom Chaga, Inonotus obliquus
2 Marjoram (Origanum majorana)
2 Phycocyanin
2 Shikonin
1 1,8-Cineole
1 Astragalus
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Cisplatin
1 Aspirin
1 Aloe anthraquinones
1 Biochanin A
1 Beta-Caryophyllene
1 Chemotherapy
1 brusatol
1 Bacopa monnieri
1 Black Rice, Oryza sativa
1 Carnosic acid
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 chitosan
1 Selenium NanoParticles
1 Zinc
1 Coenzyme Q10
1 Cucurbitacin
1 Ursolic acid
1 Cyclopamine
1 Cysteamine
1 D-limonene
1 Ginkgo biloba-EGb 761
1 Eurycomanone
1 Sorafenib (brand name Nexavar)
1 Flaxseed/Linseed
1 5-fluorouracil
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Proanthocyanidins
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 phytic acid, Inositol hexakisphosphate
1 Isoliquiritigenin
1 isoorientin
1 Ivermectin
1 Juglone
1 Lactobacillus
1 gefitinib, erlotinib
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 tamoxifen
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 Oleuropein
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Propyl gallate
1 temozolomide
1 Piperlongumine
1 Polyphenols
1 Parthenolide
1 Spirulina(Arthrospira/Limnospira)
1 Aflavin-3,3′-digallate
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:201  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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