ATP Cancer Research Results

ATP, Adenosine triphosphate: Click to Expand ⟱
Source:
Type:
Adenosine triphosphate (ATP) is the source of energy for use and storage at the cellular level.
Cellular ATP levels are critical for cell survival, and several reports have shown that reductions in cellular ATP levels can lead to apoptosis and other types of cell death in cancer cells, depending on the level of depletion.
Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors expressed by immune and cancer cells.

Cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the “Warburg effect”, and the remaining 40% is derived from mitochondrial oxidative phosphorylation.
Scientific Papers found: Click to Expand⟱
935- Gallo,    Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
LDH↓, ROS↑, TumCP↓, Glycolysis↓, ATP↓, ER-α36↓, Apoptosis?,
7195- GBE,    Mitochondrial effects of Ginkgo biloba extract
- Review, AD, NA
*ROS↓, *mitResp↑, *AntiAge↑, *ATP↑, *neuroP↑, *ETC↑, *compI↑,
7212- GBE,    The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *mitResp↑, *Casp9↓, *Casp3↓, *Apoptosis↓, *ATP↑, *neuroP↑, *IL1β↓, *IL6↓, *TNF-α↓, *PGE2↓, *memory↑, *cognitive↑, *BloodF↑, *lipid-P↓, *Aβ↓, *MAOA↓, *DA↑, *Dose↝, *toxicity↓,
7282- Gins,    Ginsenoside Rh2 stimulates the production of mitochondrial reactive oxygen species and induces apoptosis of cervical cancer cells by inhibiting mitochondrial electron transfer chain complex
- in-vitro, Cerv, NA
compI↓, compIII↓, ETC↓, ROS↑, Apoptosis↑, tumCV↓, selectivity↑, MMP↓, ATP↓, OXPHOS↓, ECAR↓, Glycolysis↓,
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,
7310- Gos,    Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells
- in-vitro, AML, NA
TumCD↑, MOMP↑, ROS↑, ATP↓, BAX↑, Cyt‑c↑, AIF↑,
845- Gra,    A Review on Annona muricata and Its Anticancer Activity
- Review, NA, NA
GlucoseCon↓, ATP↓, HIF-1↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ERK↓, Akt↓, Apoptosis↑, NF-kB↓, ROS↑, Bax:Bcl2↑, MMP↓, Casp3↑, Casp9↑, p‑JNK↓,
840- Gra,    Evaluation of cytotoxicity of aqueous extract of Graviola leaves on squamous cell carcinoma cell-25 cell lines by 3-(4,5-dimethylthiazol-2-Yl) -2,5-diphenyltetrazolium bromide assay and determination of percentage of cell inhibition at G2M phase of cell cycle by flow cytometry: An in vitro study
- in-vitro, SCC, SCC25
TumCCA↑, ATP↓,
836- Gra,    Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism
- vitro+vivo, PC, NA
Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, TumCCA↑, TumMeta↓, GlucoseCon↓, ATP↓, necrosis↑, Casp∅, p‑FAK↓, MMP9↓, MUC4↓,
7335- Gra,    Effect of Annona muricata (Soursop) on Patients with Cancer: A Systematic Review
- Review, Var, NA
TumCG↓, Casp↑, Inflam↓, toxicity↓, other↑, TumCCA↑, Apoptosis↑, TumAuto↑, ATP↓, AIF↑, MMP↓, MOMP↑, Cyt‑c↑, selectivity↑, hepatoP∅,
1232- Gra,    Graviola: A Systematic Review on Its Anticancer Properties
- Review, NA, NA
EGFR↓, cycD1/CCND1↓, Bcl-2↓, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, BAX↑, Cyt‑c↑, Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ATP↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, eff↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑,
7483- H2,  Cisplatin,    Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism
- in-vivo, Nor, HK-2
RenoP↑, BHB↑, HMGCS2↑, chemoP↑, *IL2↓, *IL6↓, *MCP1/CCL2↓, *TNF-α↓, *KeyT↝, *Inflam↓, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *PGC-1α↑, *BUN↓, *creat↓,
2512- H2,    Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch
- in-vivo, asthmatic, NA
selectivity↑, lactateProd↓, ATP↑, HK2↓, PFK↓, Hif1a↓, PGC-1α↑, Glycolysis↓, OXPHOS↑, Dose↝,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *BP∅, *BBB↑,
7503- H2S,    Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells
- Review, Var, NA
DNArepair↑, CBS↑, 3MST/MPST↑, ETC↑, ATP↑, Glycolysis↑, ACLY↑,
960- HNK,    Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, MDA-MB-231
OCR↑, ECAR↓, GlucoseCon↓, lactateProd↓, ATP↓, Glycolysis↓, Hif1a↓, GLUT1↓, HK2↓, PDK1↓, Apoptosis↑, LDHA↓,
2879- HNK,    Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function
- in-vitro, Lung, H226 - in-vivo, NA, NA
tumCV↓, selectivity↑, TumCP↓, TumCCA↑, Apoptosis↑, mt-ROS↑, Casp3↑, Casp7↑, OCR↓, Cyt‑c↑, ATP↓, mitResp↓, AMP↑, AMPK↑,
2887- HNK,    Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming
- in-vitro, AD, BV2
*Glycolysis↑, *ATP↑, *ROS↓, *MMP↑, *OXPHOS↑, *PPARα↑, *PGC-1α↑,
886- HPT,    Impact of hyper- and hypothermia on cellular and whole-body physiology
- Analysis, NA, NA
MMP↓, OXPHOS↓, ATP↓, ROS↑, Apoptosis↑, Cyt‑c↑,
7775- IBC,    Isobavachalcone Induces Multiple Cell Death in Human Triple-Negative Breast Cancer MDA-MB-231 Cells
- vitro+vivo, BC, MDA-MB-231
TumCP↓, Apoptosis↑, Necroptosis↑, TumAuto↑, Akt↓, BAX↑, cl‑Casp3↑, RIP3↑, p‑RIP3↑, MLKL↑, LC3‑Ⅱ/LC3‑Ⅰ↑, mtDam↑, ATP↓, ROS↑, TumCG↓,
7636- Ins,    Myo-Inositol: Pharmacokinetics, Biological Functions, and Therapeutic Potential in Liver Protection: Insights from Preclinical Models
*glucose↝, *lipid-P↓, *ROS↓, *BioAv↑, *hepatoP↑, *Inflam↓, *MMP↑, *ATP↑, *GutMicro↑, *Dose↝, *Half-Life↝, *BioAv↑, *eff↑, *hepatoP↑, *SOD↑, *Catalase↑, *Casp3↓, *ALAT↓, *AST↓, *AMPK↑, *SREBP1/SREBF1↑, *NA↑,
7744- ISL,    Isoliquiritigenin suppresses fatty acid synthesis and cancer cell migration in anaplastic thyroid carcinoma through AMPK/SREBF1 pathway
- vitro+vivo, Thyroid, NA
AntiTum↑, TumCP↓, TumCMig↓, E-cadherin↑, N-cadherin↓, FASN↓, SREBP1/SREBF1↓, ATP↓, p‑AMPK↑, lipidLev↓, TumCG↓, lipoGen↓,
7755- ISL,    Isoliquiritigenin attenuated cognitive impairment, cerebral tau phosphorylation and oxidative stress in a streptozotocin-induced mouse model of Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *p‑T-cadherin↓, *ROS↓, *ATP↑, *p‑DRP1/DNM1L↝, *MFN1↝, *MFN2↝, *neuroP↑, *cognitive↑, *mTOR↓, *ERK↓, *GSK‐3β↑,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
7816- ISQ,    Isoquercitrin Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Gastric Cancer Cells
- in-vitro, GC, AGS - in-vitro, GC, HGC27
TumCP↑, Bcl-2↓, BAX↑, cl‑Casp3↑, Casp12↑, MMP↓, CRT↑, e-ATP↑, HMGB1↑, HSP70/HSPA5↑, HSP90↑, ER Stress↑,
1070- IVM,    Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation
- vitro+vivo, GBM, NA
TumCG↓, LC3II↑, p62↓, ATP↓, Pyruv↓, GlucoseCon↑, HK2↓, PFK1↓, GLUT4↓, Glycolysis↓, JAK2↓, p‑STAT3↓, p‑STAT5↓,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE/β-secretase↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *eff↑,
2913- LT,    Luteolin induces apoptosis by impairing mitochondrial function and targeting the intrinsic apoptosis pathway in gastric cancer cells
- in-vitro, GC, HGC27 - in-vitro, BC, MCF7 - in-vitro, GC, MKN45
TumCP↓, MMP↓, Apoptosis↑, ROS↑, SOD↓, ATP↓, Bax:Bcl2↑, TumCCA↑,
2542- M-Blu,    In Vitro Methylene Blue and Carboplatin Combination Triggers Ovarian Cancer Cells Death
- in-vitro, Ovarian, OV1369 - in-vitro, Ovarian, OV1946 - in-vitro, Nor, ARPE-19
BioAv↝, TumCP↓, GlutaM↓, Warburg↓, OCR↑, Glycolysis↓, ATP↓, BioAv↝, ROS↑,
2643- MCT,    Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism
- Review, Nor, NA
*Akt↑, *AMPK↓, *TGF-β↓, eff↑, *BioEnh↑, *ATP↑, *PGC-1α↑, *p‑mTOR↑, *SMAD3↓,
1780- MEL,    Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing
- Review, Var, NA
*antiOx↑, *toxicity↓, ChemoSen↑, *eff↑, *mitResp↑, *ATP↑, *ROS↓, *CardioT↓, *GSH↑, *NOS2↓, *lipid-P↓, eff↑, *HO-1↑, *NRF2↑, *NF-kB↑, TumCP↓, eff↑, neuroP↑,
1778- MEL,    Melatonin: a well-documented antioxidant with conditional pro-oxidant actions
- Review, Var, NA - Review, AD, NA
*ROS↓, *antiOx↓, ROS↑, selectivity↑, Dose↑, *mitResp↑, *ATP↑, *ROS↓, eff↑, ROS↑, Dose↑, *toxicity∅, ROS↑, eff↓, ROS↝, Dose↑, other↑,
995- MEL,    Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma
- vitro+vivo, GBM, NA
LDHA↓, MCT4↓, lactateProd↓, i-pH↓, ROS↑, ATP↓, TumCD↑, TumCCA↑, PDH↓, Glycolysis↓, GlucoseCon↓, TumCG↓,
6419- MEL,    The potential influence of melatonin on mitochondrial quality control: a review
- Review, Nor, NA
*mt-ACC⇅, *PKM1↑, *PKM2↑, *Glycolysis↝, *PDKs↑, *FAO↑, *ETC↑, *OXPHOS↑, *ATP↑, Glycolysis↓, OXPHOS↑, *Ca+2↓, *ROS↓, *antiOx↑, *SOD2↑, *GPx↑, *Catalase↑, *MFN1↑, *MFN2↑, *OPA1↑, *YAP/TEAD↑, *Hippo↑, *SIRT1↑, *PGC-1α↑, *DRP1/DNM1L↓,
5800- MET,    Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
- Review, Var, NA
ChemoSen↑, RadioS↑, Imm↑, *AntiDiabetic↑, *AMPK↑, TumCP↓, hepatoP↑, ATP↓, AMP↑, glucoNG↓, ROS↑, compI↓, DNAdam↑, CSCs↓, NP/CIPN↓, chemoP↑, toxicity↓, Trx↓, eff↑, cycD1/CCND1↓, CDK4↓, CDK6↓, cycE/CCNE↓, CDK2↓,
2457- MET,    Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II
- in-vitro, Lung, Calu-1
HK1↓, HK2↓, GlucoseCon↓, MMP↓, ATP↓,
994- MET,    Tumor metabolism destruction via metformin-based glycolysis inhibition and glucose oxidase-mediated glucose deprivation for enhanced cancer therapy
- in-vitro, Var, NA
Glycolysis↓, HK2↓, ATP↓, AMPK↑, P53↑, Warburg↓, Apoptosis↑,
2242- MF,    Electromagnetic stimulation increases mitochondrial function in osteogenic cells and promotes bone fracture repair
- in-vitro, Nor, NA
*MMP↑, *Diff↑, *OXPHOS↑, *BMD↑, ATP∅,
2247- MF,    Effects of Pulsed Electromagnetic Field Treatment on Skeletal Muscle Tissue Recovery in a Rat Model of Collagenase-Induced Tendinopathy: Results from a Proteome Analysis
- in-vivo, Nor, NA
*Glycolysis↓, *LDHB↑, *NAD↑, *ATP↑, *antiOx↑, *ROS↑, *YAP/TEAD↑, *PGC-1α↑, *TCA↑, *FAO↑, *OXPHOS↑,
3477- MF,    Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
- Review, NA, NA
*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,
538- MF,    The extremely low frequency electromagnetic stimulation selective for cancer cells elicits growth arrest through a metabolic shift
- in-vitro, BC, MDA-MB-231 - in-vitro, Melanoma, MSTO-211H
TumCG↓, Ca+2↑, COX2/PTGS2↓, ATP↑, MMP↑, ROS↑, OXPHOS↑, mitResp↑,
531- MF,    6-mT 0-120-Hz magnetic fields differentially affect cellular ATP levels
- in-vitro, Cerv, HeLa - in-vitro, CRC, HCT116 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, RPE-1 - in-vitro, Nor, GP-293
ATP⇅,
537- MF,  immuno,    Integrating electromagnetic cancer stress with immunotherapy: a therapeutic paradigm
- Review, Var, NA
Apoptosis↑, ROS↑, TumAuto↑, Ca+2↑, ATP↓, eff↑, eff↑,
493- MF,    Extremely low-frequency electromagnetic field induces acetylation of heat shock proteins and enhances protein folding
- in-vitro, NA, HEK293 - in-vitro, Liver, AML12
ATP↑, HSP70/HSPA5↓, HSP90↓,
4355- MF,    Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism
- in-vitro, Nor, C2C12
*mt-OCR↑, *mt-ROS↑, *ECAR↑, *Dose↝, *Ca+2↑, *ATP↑, *other↑, *eff↓, *eff↝,
5241- MF,    A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment
- Review, Var, NA
other↑, BloodF↑, Glycolysis↓, ATP↓, VEGF↓, ROS↑, P-gp/ABCB1↓, Apoptosis↑, selectivity↑, Ca+2↑, Catalase↑,
773- Mg,    Methyl Jasmonate-induced Increase in Intracellular Magnesium Promotes Apoptosis in Breast Cancer Cells
- in-vitro, BC, MCF7
TRPM7↓, ROS↑, ER Stress↑, MAPK↑, ATP↓,
1891- MGO,    Methylglyoxal induces mitochondria-dependent apoptosis in sarcoma
- in-vitro, SCC, NA
NADH↓, MMP↓, Cyt‑c↑, selectivity↑, Apoptosis↑, ROS↑, ATP↓,
2451- PA,    The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors
- Review, Var, NA
HK2↓, ATP↓, ROS↑,

Showing Research Papers: 101 to 150 of 217
Prev Page 3 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 217

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

3MST/MPST↑, 1,   BHB↑, 1,   CBS↑, 1,   CD47↓, 1,   CUL1↝, 1,   CUL5↝, 1,   CX43/GJA1↓, 1,   HLA-I/II↑, 1,   HMGCS2↑, 1,   miR-124-3p↓, 1,   PFS↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ARE↓, 1,   Catalase↑, 1,   compI↓, 2,   HK1↓, 1,   NADH↓, 1,   NRF2↓, 1,   OXPHOS↓, 3,   OXPHOS↑, 3,   ROS↓, 1,   ROS↑, 24,   ROS↝, 1,   mt-ROS↑, 1,   SOD↓, 1,   Trx↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 27,   ATP↑, 4,   ATP⇅, 1,   ATP∅, 1,   e-ATP↑, 1,   compIII↓, 1,   ETC↓, 1,   ETC↑, 1,   mitResp↓, 1,   mitResp↑, 1,   MMP↓, 9,   MMP↑, 1,   mtDam↑, 3,   OCR↓, 1,   OCR↑, 2,   PGC-1α↑, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↑, 1,   AMP↑, 2,   AMPK↑, 2,   p‑AMPK↑, 1,   ECAR↓, 2,   FASN↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 5,   GlucoseCon↑, 1,   GlutaM↓, 1,   Glycolysis↓, 12,   Glycolysis↑, 1,   HK2↓, 9,   lactateProd↓, 3,   LDH↓, 1,   LDHA↓, 5,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   PDH↓, 1,   PDK1↓, 1,   PFK↓, 1,   PFK1↓, 1,   Pyruv↓, 1,   SCD1↓, 1,   SREBP1/SREBF1↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   Apoptosis?, 1,   Apoptosis↑, 17,   BAX↑, 4,   Bax:Bcl2↑, 2,   Bcl-2↓, 3,   Casp↑, 1,   Casp∅, 1,   Casp12↑, 1,   Casp3↑, 3,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp9↑, 2,   Cyt‑c↑, 6,   hTERT/TERT↓, 1,   IAP2/BIRC3↓, 1,   p‑JNK↓, 1,   MAPK↑, 3,   MDM2↓, 1,   MLKL↑, 1,   MOMP↑, 3,   Necroptosis↑, 2,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 2,   survivin↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   other↑, 3,   other↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CRT↑, 1,   ER Stress↑, 3,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   DNArepair↑, 1,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 2,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 2,   ERK↓, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,   p‑STAT5↓, 1,   TRPM7↓, 1,   TumCG↓, 6,  

Migration(tgid=13) ⓘ

Ca+2↑, 5,   E-cadherin↑, 1,   ER-α36↓, 1,   FAK↓, 1,   p‑FAK↓, 1,   MALAT1↓, 1,   MMP9↓, 1,   MUC4↓, 1,   N-cadherin↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   TumCA↓, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 10,   TumCP↑, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   EGFR↓, 1,   HIF-1↓, 1,   Hif1a↓, 5,   NO↑, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 4,   GLUT4↓, 5,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   HMGB1↑, 1,   ICAM-1↓, 1,   IL6↓, 1,   Imm↑, 2,   Inflam↓, 2,   JAK↓, 1,   JAK2↓, 1,   NF-kB↓, 4,   NK cell↑, 1,   TLR4↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

i-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   CDK6↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 2,   ChemoSen↑, 3,   Dose↑, 3,   Dose↝, 4,   eff↓, 2,   eff↑, 10,   RadioS↑, 2,   selectivity↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   EGFR↓, 1,   EZH2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   chemoP↑, 3,   hepatoP↑, 1,   hepatoP∅, 1,   neuroP↑, 1,   NP/CIPN↓, 2,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 3,   TumVol↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 2,  
Total Targets: 198

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

compII↑, 1,   DA↑, 1,   NA↑, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 8,   ARE↑, 1,   Catalase↑, 5,   compI↑, 1,   GPx↑, 3,   GSH↑, 1,   HO-1↑, 4,   lipid-P↓, 4,   MDA↓, 2,   MFN1↑, 1,   MFN1↝, 1,   MFN2↑, 2,   MFN2↝, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 5,   OPA1↑, 1,   OXPHOS↑, 4,   ROS↓, 14,   ROS↑, 2,   mt-ROS↑, 1,   SOD↑, 4,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 16,   compIII↑, 1,   DRP1/DNM1L↓, 1,   p‑DRP1/DNM1L↝, 1,   ETC↑, 2,   mitResp↑, 4,   MMP↑, 5,   mtDam↓, 1,   mt-OCR↑, 1,   PGC-1α↑, 5,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

mt-ACC⇅, 1,   ALAT↓, 2,   AMPK↓, 1,   AMPK↑, 3,   BUN↓, 1,   CREB↑, 1,   ECAR↑, 1,   FAO↑, 2,   glucose↝, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   Glycolysis↝, 1,   KeyT↝, 1,   LDHB↑, 1,   LDL↓, 1,   NAD↑, 1,   NADPH↑, 1,   PDKs↑, 1,   PKM1↑, 1,   PKM2↑, 1,   PPARα↑, 1,   PPARγ↑, 1,   SIRT1↑, 1,   SREBP1/SREBF1↑, 1,   TCA↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   Apoptosis↓, 1,   Bax:Bcl2↓, 1,   Casp12↓, 1,   Casp3↓, 3,   Casp9↓, 1,   Casp9↑, 1,   GranB/GZMB↓, 1,   Hippo↑, 1,   p‑JNK↓, 1,   MAPK↓, 1,   p38↓, 1,   YAP/TEAD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   ERK↓, 1,   FOXO3↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   mTOR↓, 2,   p‑mTOR↑, 1,   PI3K↑, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

APP↓, 2,   Ca+2↓, 1,   Ca+2↑, 2,   FAK↑, 1,   SMAD3↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   ATF4↓, 1,   NO↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   IBI↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   IFN-γ↓, 1,   IL10↑, 1,   IL1β↓, 4,   IL2↓, 1,   IL33↓, 1,   IL4↓, 1,   IL6↓, 4,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 6,   LPS↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 2,   NF-kB↑, 1,   PGE2↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 2,   MAOA↓, 1,   tau↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 4,   BACE/β-secretase↓, 3,   NLRP3↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 2,   BioEnh↑, 1,   Dose↝, 5,   eff↓, 1,   eff↑, 4,   eff↝, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BloodF↑, 2,   BMD↑, 1,   BP∅, 1,   creat↓, 2,   GutMicro↑, 2,   IL6↓, 4,   NOS2↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 1,   antiPs↑, 1,   cardioP↑, 1,   CardioT↓, 1,   cognitive↑, 5,   hepatoP↑, 4,   memory↑, 4,   neuroP↑, 7,   Obesity↓, 1,   RenoP↑, 1,   toxicity↓, 3,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Sepsis↓, 1,  
Total Targets: 168

Scientific Paper Hit Count for: ATP, Adenosine triphosphate
11 3-bromopyruvate
9 Magnetic Fields
9 Vitamin C (Ascorbic Acid)
6 Berberine
6 Citric Acid
6 Resveratrol
6 Shikonin
5 Silver-NanoParticles
5 Alpha-Lipoic-Acid
5 Graviola
5 Quercetin
5 salinomycin
4 Ashwagandha(Withaferin A)
4 Capsaicin
4 Curcumin
4 EGCG (Epigallocatechin Gallate)
4 Emodin
4 Hydrogen Gas
4 Melatonin
4 Urolithin
3 2-DeoxyGlucose
3 Apigenin (mainly Parsley)
3 Propolis -bee glue
3 immunotherapy
3 Crocetin
3 Copper and Cu NanoParticles
3 diet FMD Fasting Mimicking Diet
3 Honokiol
3 Isoliquiritigenin
3 Luteolin
3 Metformin
3 Rosmarinic acid
3 Sulforaphane (mainly Broccoli)
3 Silymarin (Milk Thistle) silibinin
3 Ursolic acid
2 Radiotherapy/Radiation
2 Allicin (mainly Garlic)
2 DTS(dibenzyl trisulphide) from Anamu
2 chaetocin
2 Chrysin
2 Cucurbitacin
2 Diclofenac
2 Docosahexaenoic Acid
2 Chemotherapy
2 Ginkgo biloba-EGb 761
2 Formononetin
2 Galloflavin
2 Ginkgo biloba
2 Gossypol/AT-101
2 Pachymic acid
2 Phenethyl isothiocyanate
2 Thymoquinone
2 Vitamin B5,Pantothenic Acid
2 Vitamin K2
1 Sorafenib (brand name Nexavar)
1 cetuximab
1 Anthocyanins
1 Auranofin
1 Acetyl-l-carnitine
1 Andrographis
1 doxorubicin
1 Artemisinin
1 Aloe anthraquinones
1 Betulinic acid
1 Boron
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Carvacrol
1 Cannabidiol
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Cichoric acid / Chicoric acid
1 Dichloroacetate
1 Disulfiram
1 Electrical Pulses
1 Ferulic acid
1 Ginseng
1 Cisplatin
1 hydrogen sulfide
1 Hyperthermia
1 Isobavachalcone
1 Inositol
1 isoquercitrin
1 Ivermectin
1 Methylene blue
1 MCToil
1 Magnesium
1 Methylglyoxal
1 Pterostilbene
1 Radio Frequency
1 EMF
1 SonoDynamic Therapy UltraSound
1 triptolide
1 Vitamin B1/Thiamine
1 Vitamin B12
1 Folic Acid, Vit B9
1 Vitamin B2,Riboflavin
1 Arsenic trioxide
1 probiotics
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:21  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page