NRF2 Cancer Research Results

NRF2, nuclear factor erythroid 2-related factor 2: Click to Expand ⟱
Source: TCGA
Type: Antiapoptotic
Nrf2 is responsible for regulating an extensive panel of antioxidant enzymes involved in the detoxification and elimination of oxidative stress. Thought of as "Master Regulator" of antioxidant response.
-One way to estimate Nrf2 induction is through the expression of NQO1.
NQO1, the most potent inducer:
SFN 0.2 μM,
quercetin (2.5 μM),
curcumin (2.7 μM),
Silymarin (3.6 μM),
tamoxifen (5.9 μM),
genistein (6.2 μM ),
beta-carotene (7.2μM),
lutein (17 μM),
resveratrol (21 μM),
indol-3-carbinol (50 μM),
chlorophyll (250 μM),
alpha-cryptoxanthin (1.8 mM),
and zeaxanthin (2.2 mM)

1. Raising Nrf2 enhances the cell's antioxidant defenses and ↓ROS. This strategy is used to decrease chemo-radio side effects.
2. Downregulating Nrf2 lowers antioxidant defenses and ↑ROS. In cancer cells this leads to DNA damage, and cell death.
3. However there are some cases where increasing Nrf2 paradoxically causes an increase in ROS (cancer cells). Such as cases of Mitochondial overload, signal crosstalk, reductive stress

-In some cases, Nrf2 is overexpressed in cancer cells, which can lead to the activation of genes involved in cell proliferation, angiogenesis, and metastasis. This can contribute to the development of resistance to chemotherapy and targeted therapies.
-Increased Nrf2 expression: Lung, Breast, Colorectal, Prostrate.
Decreased Nrf2 expression: Skine, Liver, Pancreatic.
-Nrf2 is a cytoprotective transcription factor which demonstrated both a negative effect as well as a positive effect on cancer
- "promotes Nrf2 translocation from the cytoplasm to the nucleus," means facilitates the movement of Nrf2 into the nucleus, thereby enhancing the cell's antioxidant and cytoprotective responses. -Major regulator of Nrf2 activity in cells is the cytosolic inhibitor Keap1.

Nrf2 Inhibitors and Activators
Nrf2 Inhibitors: Brusatol, Luteolin, Trigonelline, VitC, Retinoic acid, Chrysin
Nrf2 Activators: SFN, OPZ EGCG, Resveratrol, DATS, CUR, CDDO, Api
- potent Nrf2 inducers from plants include sulforaphane, curcumin, EGCG, resveratrol, caffeic acid phenethyl ester, wasabi, cafestol and kahweol (coffee), cinnamon, ginger, garlic, lycopene, rosemany

Nrf2 plays dual roles in that it can protect normal tissues against oxidative damage and can act as an oncogenic protein in tumor tissue.
– In healthy tissues, NRF2 activation helps protect cells from oxidative damage and maintains cellular homeostasis.
– In many cancers, constitutive activation of NRF2 (often through mutations in NRF2 itself or loss-of-function mutations in KEAP1) leads to an enhanced antioxidant capacity.
– This upregulation can promote tumor cell survival by enabling cancer cells to thrive under oxidative stress, resist chemotherapeutic agents, and sustain metabolic reprogramming.
– Elevated NRF2 levels have been implicated in promoting tumor growth, metastasis, and resistance to therapy in various malignancies.
– High or sustained NRF2 activity is frequently associated with aggressive tumor phenotypes, poorer prognosis, and decreased overall survival in several cancer types.
– While its activation is essential for protecting normal cells from oxidative stress, aberrant or sustained NRF2 activation in tumor cells can lead to enhanced survival, therapeutic resistance, and tumor progression.

NRF2 inhibitors: (to decrease antioxidant defenses and increase cell death from ROS).
-Brusatol: most cited natural inhibitors of Nrf2.
-Luteolin: luteolin can reduce Nrf2 activity in specific cancer models and may enhance cell sensitivity to chemotherapy. However, luteolin is also known as an antioxidant, and its influence on Nrf2 can sometimes be context dependent.
-Apigenin: certain studies to down‑regulate Nrf2 in cancer cells: Dose and context dependent .
-Oridonin:
-Wogonin: although its effects might be cell‑ and dose‑specific.
- Withaferin A

Scientific Papers found: Click to Expand⟱
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
1425- Bos,    Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway
- in-vivo, Nor, NA
*ChemoSen↑, *NRF2↑, *HO-1↑, *ROS↓, *lipid-P↓, *DNAdam↓,
5691- BRU,    Brusatol Inhibits Proliferation, Migration, and Invasion of Nonsmall Cell Lung Cancer PC-9 Cells
- in-vitro, Lung, PC9 - in-vitro, Lung, H1975
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EGFR↓, β-catenin/ZEB1↓, Akt↓, STAT3↓, TumMeta↓, ChemoSen↑, NRF2↓, Akt↓, mTOR↓,
5693- BRU,    Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2
- in-vivo, HCC, NA
NRF2↓, eff↑, p‑MAPK↑, p‑Akt↑, p‑ERK↑, p‑JNK↑,
5694- BRU,    Brusatol overcomes chemoresistance through inhibition of protein translation
- in-vitro, Lung, A549
NRF2↓, P53↓, P21↓,
5695- BRU,    Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
- in-vitro, Lung, A549
NRF2↓, ChemoSen↑, Apoptosis↑, TumCP↓, TumCG↓, MRP1↓, GSH↓, cMyc↓,
5696- BRU,    The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer
- in-vitro, CRC, HCT116
NRF2↓, tumCV↓, ChemoSen↑,
5697- BRU,    Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma
- in-vitro, HNSCC, NA
NRF2↓, STAT3↓, proCasp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, Hif1a↓, cMyc↓, JNK↑, MAPK↑, tumCV↓, ROS∅,
5698- BRU,    Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma
- in-vitro, HCC, NA
TumCMig↓, EMT↓, STAT3↓, E-cadherin↑, NRF2↓, ChemoSen↑, RadioS↑, DNAdam↑, TumCMig↓, TumCI↓, toxicity↓,
5699- BRU,  BJ,    Identification of the Brucea javanica Constituent Brusatol as a EGFR-Tyrosine Kinase Inhibitor in a Cell-Free Assay
- in-vitro, Lung, A549
EGFR↓, ChemoSen↑, NRF2↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ROCK1↓, Hif1a↓,
5703- BRU,    Brusatol Enhances the Radiosensitivity of A549 Cells by Promoting ROS Production and Enhancing DNA Damage
- in-vitro, Lung, H1299 - in-vitro, Lung, A549 - in-vitro, Lung, H460
NRF2↓, RadioS↑, DNAdam↑, ROS↑,
5701- BRU,    Brusatol induced ferroptosis in osteosarcoma cells by modulating the Keap1/Nrf2/SLC7A11 signaling pathway
- in-vitro, OS, NA
TumMeta↓, TumCP↓, ROS↑, Ferroptosis↑, NRF2↓, ChemoSen↑,
5700- BRU,    Brusatol modulates the Nrf2/GCLC pathway to enhance ferroptosis in the treatment of oral squamous cell carcinoma
- in-vitro, Oral, CAL27
TumCG↓, Ferroptosis↑, TumCMig↓, NRF2↓, i-GSH↓, Iron↑, ROS↑,
5740- Buty,    A Review of Nutritional Regulation of Intestinal Butyrate Synthesis: Interactions Between Dietary Polysaccharides and Proteins
- Review, RCC, NA
*eff↓, Dose↝, eff↑, HDAC↓, ac‑H3↓, ac‑H4↓, *HCAR2↑, *Inflam↓, *ROS↓, *NRF2↑, *GSH↑, *CLDN1↑, *ZO-1↑, IL1β↓, IL6↓, COX2↓, eff↝, eff↑, other↝,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
4264- CA,    Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2HO-1 Pathway
- in-vivo, NA, NA
*NRF2↑, *HO-1↑, *Trx1↑, *BDNF↑, *5HT↑, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓,
4265- CA,    Potential applications of nanomedicine for treating Parkinson's disease
- Review, Park, NA
*NRF2↑, *ARE↑, *neuroP↑, *motorD↑, *cognitive↑, *SOD↑, *GSR↑, *NGF↑, *BDNF↑,
2394- CAP,    Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction
- in-vitro, Nor, GES-1
*mtDam↓, *NRF2↑, *HO-1↑, *Trx↑, *GSS↑, *NQO1↑, *Keap1↓, *ROS↓, *PKM2↓, *LDHA↓, *Inflam↓,
2392- Cela,    The role of natural products targeting macrophage polarization in sepsis-induced lung injury
- Review, Sepsis, NA
TNF-α↓, IL1β↓, IL6↓, Warburg↓, PKM2↓, NRF2↑, HO-1↑, NF-kB↓, iNOS↓, M1↓,
2590- CHr,    Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway
- in-vitro, GBM, T98G - in-vitro, GBM, U251 - in-vitro, GBM, U87MG
TumCP↓, TumCMig↓, TumCI↓, NRF2↓, HO-1↓, NADPH↓, ERK↓,
2591- CHr,  doxoR,    Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway
- in-vitro, HCC, Bel-7402
NRF2↓, ChemoSen↑, HO-1↓,
2807- CHr,    Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats
- in-vivo, Nor, NA
*antiOx↑, Inflam↓, *cardioP↑, *GSH↑, *SOD↑, *Catalase↑, *GAPDH↑, *BAX↓, *Bcl-2↑, *PARP↓, *Cyt‑c↓, *Casp3↓, *NOX4↓, *NRF2↑, *HO-1↑, *HSP70/HSPA5↑,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, eff↑, eff↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, eff↑,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
1410- CUR,    Curcumin induces ferroptosis and apoptosis in osteosarcoma cells by regulating Nrf2/GPX4 signaling pathway
- vitro+vivo, OS, MG63
tumCV↓, Apoptosis↑, TumCG↓, NRF2↓, GPx4↓, HO-1↓, xCT↓, ROS↑, MDA↑, GSH↓,
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
ChemoSen↑, NF-kB↓, *STAT3↓, *COX2↓, *Akt↓, *NRF2↑, *HO-1↑, *GPx↑, *NADPH↑, *GSH↑, *ROS↓, *p300↓, radioP↑, chemoP↑, RadioS↑,
1510- CUR,  Chemo,    Combination therapy in combating cancer
- Review, NA, NA
*NRF2↑, *GSH↑, *ROS↓, ChemoSideEff↓, eff↑, OS↓, chemoP↑,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
13- CUR,    Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
- Review, BC, NA
P53↑, DR5↑, JNK↑, NRF2↑, PPARγ↑, HER2/EBBR2↓, IR↓, ER(estro)↓, Fas↑, PDGF↓, TGF-β↓, FGF↓, EGFR↓, JAK↓, PAK↓, MAPK↓, ATPase↓, COX2↓, MMPs↓, IL1↓, IL2↓, IL5↓, IL6↓, IL8↓, IL12↓, IL18↓, NF-kB↓, NOTCH1↓, STAT1↓, STAT4↓, STAT5↓, STAT3↓,
405- CUR,  5-FU,    Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis
- vitro+vivo, CRC, HCT116
Apoptosis↑, TumCMig↓, NRF2↑, ROS↑, MET↑, miR-34a↑,
410- CUR,    Nrf2 depletion enhanced curcumin therapy effect in gastric cancer by inducing the excessive accumulation of ROS
- vitro+vivo, GC, AGS - vitro+vivo, GC, HGC27
ROS↑, NRF2↑,
414- CUR,    Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, GSH↓, HO-1↑, NRF2↑, GPx↓, ROS↑, Iron↑, GPx4↓, HSP70/HSPA5↑, ATFs↑, CHOP↑, MDA↑, FTL↑, FTH1↑, BACH1↑, REL↑, USF1↑, NFE2L2↑,
2819- CUR,  Chemo,    Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
- Review, Var, NA
*hepatoP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *ROS↓, *ALAT↓, *AST↓, *MDA↓, *NRF2↑, *COX2↑, *NF-kB↓, *ICAM-1↓, *MCP1↓, *HO-1↑, CXCc↓,
2821- CUR,    Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)
- Review, Var, NA
*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP↑,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,
4831- CUR,    The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity
- in-vitro, NA, NA
*NRF2↑, *P53↓, *NF-kB↓, ROS↑, Inflam↓, ChemoSen↑,
4881- CUR,  SFN,  RES,  EGCG,  Lyco  An update of Nrf2 activators and inhibitors in cancer prevention/promotion
- Review, Var, NA
*NRF2↑, *antiOx↑,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
3581- CUR,    Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer's Disease
- NA, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *NRF2↑, *NF-kB↓, *cognitive↑, *ROS↓, *MDA↓, *SOD↑, *Catalase↑, *INF-γ↓, *IL4↓, *memory↑, *TNF-α↓, *IL1β↓,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
4333- Cyste,    Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcription
- vitro+vivo, AD, NA
*NRF2↑, *ARE↑, *neuroP↑, *BDNF↑, *GSH↑,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, NA, NA
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
5007- DSF,  Cu,    Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma
- vitro+vivo, Oral, NA
AntiTum↑, TumCP↓, Ferroptosis↑, Iron↑, lipid-P↑, NRF2↓, HO-1↓,

Showing Research Papers: 101 to 150 of 443
Prev Page 3 of 9 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 443

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 2,   Ferroptosis↑, 4,   GPx↓, 1,   GPx4↓, 2,   GSH↓, 6,   i-GSH↓, 1,   GSTs↑, 1,   HO-1↓, 5,   HO-1↑, 3,   Iron↑, 5,   lipid-P↑, 4,   MDA↑, 3,   NFE2L2↑, 1,   NRF2↓, 20,   NRF2↑, 5,   NRF2↝, 1,   ROS↓, 1,   ROS↑, 19,   ROS↝, 1,   ROS∅, 1,   SOD↑, 1,   xCT↓, 1,  

Metal & Cofactor Biology ⓘ

FTH1↑, 1,   FTL↑, 1,  

Mitochondria & Bioenergetics ⓘ

mt-ATP↓, 1,   MMP↓, 1,   MMP↑, 1,   mtDam↑, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 1,   cMyc↓, 3,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 2,   IR↓, 1,   lactateProd↓, 1,   LDH↓, 1,   LDL↓, 1,   NADPH↓, 1,   PDK1↓, 2,   PDK3↑, 1,   PKM2↓, 1,   PPARα↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 9,   Akt↝, 1,   p‑Akt↓, 1,   p‑Akt↑, 1,   Apoptosis↑, 9,   Apoptosis↝, 1,   BAX↑, 1,   BAX↝, 1,   Bcl-2↓, 1,   Bcl-2↝, 1,   Bcl-xL↓, 2,   Bcl-xL↝, 1,   Casp↑, 3,   Casp3↑, 3,   Casp3↝, 1,   proCasp3↑, 1,   Casp9↑, 2,   Cyt‑c↑, 4,   Cyt‑c↝, 1,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 4,   hTERT/TERT↓, 2,   iNOS↓, 2,   JNK↑, 3,   JNK↝, 1,   p‑JNK↑, 2,   MAPK↓, 2,   MAPK↑, 1,   p‑MAPK↑, 1,   Mcl-1↓, 1,   survivin↓, 2,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   PAK↓, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↓, 1,   ac‑H4↓, 1,   other↑, 1,   other↝, 1,   tumCV↓, 3,   USF1↑, 1,  

Protein Folding & ER Stress ⓘ

ATF6↑, 1,   ATFs↑, 1,   CHOP↑, 2,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   PERK↑, 1,   UPR↑, 2,   XBP-1↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 5,   P53↓, 1,   P53↑, 3,   P53↝, 1,   PARP↑, 1,   cl‑PARP↑, 3,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 2,   Cyc↝, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycD1/CCND1↝, 1,   P21↓, 1,   P21↑, 2,   P21↝, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 4,   ERK↓, 3,   p‑ERK↑, 2,   FGF↓, 1,   HDAC↓, 2,   HDAC8↓, 1,   IGF-1↓, 1,   Let-7↑, 1,   miR-34a↑, 1,   mTOR↓, 6,   mTOR↝, 1,   NOTCH1↓, 1,   NOTCH1↑, 3,   PI3K↓, 3,   PI3K↑, 1,   PI3K↝, 1,   PTEN↝, 1,   SCF↓, 1,   SHP1↑, 1,   STAT1↓, 1,   STAT3↓, 8,   p‑STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 1,   TOP1↓, 2,   TumCG↓, 4,   Wnt↓, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↝, 1,   ATPase↓, 1,   BACH1↑, 1,   Ca+2↑, 2,   CLDN1↓, 1,   E-cadherin↑, 3,   p‑FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   MET↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 2,   MMP2↝, 1,   MMP9↓, 3,   MMP9↑, 1,   MMPs↓, 1,   N-cadherin↓, 1,   PDGF↓, 1,   Rho↓, 1,   ROCK1↓, 2,   Slug↓, 1,   Snail↓, 1,   TET1↑, 2,   TGF-β↓, 1,   TumCI↓, 4,   TumCMig↓, 7,   TumCP↓, 7,   TumMeta↓, 5,   TumMeta↑, 1,   Twist↓, 2,   uPA↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   ATF4↑, 1,   EGFR↓, 4,   EGFR↝, 1,   Hif1a↓, 5,   REL↑, 1,   VEGF↓, 6,   VEGF↝, 1,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   COX2↑, 1,   COX2↝, 1,   CXCc↓, 1,   CXCR4↓, 2,   IL1↓, 2,   IL10↓, 1,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 5,   IL2↓, 2,   IL2↑, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 6,   IL6↝, 1,   IL8↓, 1,   Inflam↓, 3,   JAK↓, 1,   M1↓, 1,   NF-kB↓, 8,   NF-kB↝, 1,   PD-L1↓, 1,   PGE2↓, 1,   PSA↝, 1,   TLR4↓, 1,   TNF-α↓, 4,   TNF-α↝, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   AR↝, 1,   ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 3,   ChemoSen↑, 11,   Dose↝, 1,   eff↑, 11,   eff↝, 2,   Half-Life↓, 1,   MRP1↓, 1,   RadioS↑, 4,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 2,   AR↝, 1,   EGFR↓, 4,   EGFR↝, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 6,   IL6↝, 1,   Ki-67↓, 1,   LDH↓, 1,   PD-L1↓, 1,   PSA↝, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 1,   ChemoSideEff↓, 1,   neuroP↑, 1,   OS↓, 1,   OS↑, 1,   radioP↑, 2,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 1,  
Total Targets: 256

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 9,   ARE↑, 2,   Catalase↑, 8,   GPx↑, 6,   GSH↑, 14,   GSR↓, 1,   GSR↑, 1,   GSS↑, 1,   GSTs↑, 2,   H2O2↓, 1,   HO-1↑, 14,   HO-2↓, 1,   Keap1↓, 1,   lipid-P↓, 5,   MDA↓, 7,   MPO↓, 1,   NOX4↓, 1,   NQO1↑, 3,   NRF2↑, 24,   ROS↓, 22,   mt-ROS↓, 1,   SOD↑, 12,   TBARS↓, 1,   Trx↑, 1,   Trx1↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↑, 1,   IronCh↑, 2,  

Mitochondria & Bioenergetics ⓘ

AIF↓, 1,   ATP↑, 1,   mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   AMPK↑, 1,   FGF21↑, 1,   GAPDH↑, 1,   GlucoseCon↑, 1,   Glycolysis↑, 1,   H2S↑, 1,   HK2↑, 1,   LDH↓, 1,   LDH↑, 1,   LDHA↓, 1,   LDL↓, 2,   lipidLev↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PFK↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PPARα↑, 1,   PPARγ↑, 1,   SIRT1↑, 2,  

Cell Death ⓘ

Akt↓, 2,   Akt↑, 2,   Apoptosis↓, 2,   BAX↓, 1,   Bcl-2↑, 2,   Casp3↓, 2,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 4,   JNK↓, 1,   MAPK↓, 1,  

Kinase & Signal Transduction ⓘ

HCAR2↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNArepair↑, 1,   P53↓, 1,   PARP↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Choline↑, 1,   GSK‐3β↓, 4,   HDAC↓, 1,   IGF-1↓, 1,   mTOR↓, 2,   p300↓, 1,   PI3K↓, 1,   PI3K↑, 2,   STAT↓, 1,   STAT3↓, 1,  

Migration ⓘ

5LO↓, 1,   CDK5↓, 2,   CLDN1↑, 1,   TXNIP↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,   NO↓, 3,  

Barriers & Transport ⓘ

BBB↑, 4,   GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 7,   COX2↑, 1,   CRP↓, 1,   HCAR2↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL10↑, 1,   IL12↓, 1,   IL17↓, 2,   IL1β↓, 6,   IL2↓, 2,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 4,   Imm↑, 1,   INF-γ↓, 2,   Inflam↓, 13,   MCP1↓, 2,   NF-kB↓, 7,   NF-kB↑, 2,   PGE2↓, 2,   TNF-α↓, 9,  

Synaptic & Neurotransmission ⓘ

5HT↑, 2,   AChE↓, 5,   BDNF↑, 5,   ChAT↑, 1,   NGF↑, 1,   tau↓, 1,   p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 3,   BACE↓, 1,   NLRP3↓, 2,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 1,   Half-Life↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   AST↓, 3,   CRP↓, 1,   Ferritin↑, 1,   GutMicro↑, 2,   IL6↓, 4,   LDH↓, 1,   LDH↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cardioP↑, 3,   cognitive↓, 1,   cognitive↑, 8,   hepatoP↑, 4,   memory↑, 5,   motorD↑, 1,   neuroP↑, 13,   OS↑, 2,   RenoP↑, 1,   toxicity↓, 1,  
Total Targets: 150

Scientific Paper Hit Count for: NRF2, nuclear factor erythroid 2-related factor 2
38 Sulforaphane (mainly Broccoli)
23 Thymoquinone
22 Quercetin
19 Curcumin
18 Resveratrol
16 EGCG (Epigallocatechin Gallate)
16 Lycopene
15 Shikonin
14 Luteolin
14 brusatol
13 Silymarin (Milk Thistle) silibinin
12 Alpha-Lipoic-Acid
12 Baicalein
11 Ashwagandha(Withaferin A)
11 Fisetin
10 doxorubicin
10 Apigenin (mainly Parsley)
10 Chemotherapy
9 Silver-NanoParticles
9 Selenite (Sodium)
9 Artemisinin
9 Selenium
9 Chrysin
8 Vitamin C (Ascorbic Acid)
8 Boron
8 Propolis -bee glue
8 Hydrogen Gas
8 Pterostilbene
8 Rosmarinic acid
7 Piperlongumine
6 Allicin (mainly Garlic)
6 Radiotherapy/Radiation
6 Berberine
6 Honokiol
5 Betulinic acid
5 Boswellia (frankincense)
4 Phenethyl isothiocyanate
4 Urolithin
3 Cisplatin
3 Astaxanthin
3 Berbamine
3 5-fluorouracil
3 Brucea javanica
3 Carnosic acid
3 Disulfiram
3 Copper and Cu NanoParticles
3 Magnetic Fields
3 Parthenolide
3 Selenium NanoParticles
2 Auranofin
2 Ferulic acid
2 HydroxyTyrosol
2 Methylsulfonylmethane
2 xanthohumol
2 salinomycin
2 Taurine
1 Andrographis
1 Docetaxel
1 Baicalin
1 Lapatinib
1 Biochanin A
1 Butyrate
1 Capsaicin
1 Celastrol
1 Ursolic acid
1 Cysteamine
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 Ellagic acid
1 Emodin
1 Shilajit/Fulvic Acid
1 Ginkgo biloba
1 Ginseng
1 HydroxyCitric Acid
1 Hydroxycinnamic-acid
1 Juglone
1 Magnolol
1 Melatonin
1 Metformin
1 Mushroom Lion’s Mane
1 Myricetin
1 Oleuropein
1 Propyl gallate
1 Piperine
1 Plumbagin
1 Sulfasalazine
1 Oxygen, Hyperbaric
1 irinotecan
1 acetazolamide
1 Salvia miltiorrhiza
1 Spermidine
1 erastin
1 triptolide
1 Vitamin B1/Thiamine
1 Vitamin D3
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:226  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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