p38 Cancer Research Results

p38, p38: Click to Expand ⟱
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P38, or p38 MAPK (p38 mitogen-activated protein kinase), is a protein kinase that plays a significant role in cellular responses to stress, inflammation, and apoptosis (programmed cell death). It is part of the MAPK signaling pathway, which is involved in various cellular processes, including cell growth, differentiation, and survival.
It can have both tumor-suppressive and tumor-promoting effects, depending on the type of cancer and the cellular context.

-p38 activation can contribute to tumor progression by influencing inflammatory signaling and cell-cycle regulation.
-Overexpression can correlate with poor prognosis in some studies.
Scientific Papers found: Click to Expand⟱
8175- Las,    Lasiodin Inhibits Proliferation of Human Nasopharyngeal Carcinoma Cells by Simultaneous Modulation of the Apaf-1/Caspase, AKT/MAPK and COX-2/NF-κB Signaling Pathways
- in-vitro, NPC, NA
tumCV↓, TumCMig↓, APAF1↑, Cyt‑c↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, p‑Akt↓, p‑ERK↓, p‑p38↓, p‑JNK↓, COX2/PTGS2↓, NF-kB↓, chemoPv↑,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,
8241- LCA,    Licochalcone A induces apoptotic cell death via JNK/p38 activation in human nasopharyngeal carcinoma cells
- in-vitro, NPC, NA
tumCV↓, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, ERK↑, p38↑, JNK↑, *antiAll↑, *Bacteria↓, *Inflam↓, *antiOx↑, *AntiCan↑,
8231- LCA,    Maintenance of the Expression of c-FLIPL by Hsp70 to Resist Licochalcone A-Induced Anti-Colorectal Cancer Effect through ERK-Mediated Autophagy Induction
- in-vitro, CRC, NA
TumCP↓, Apoptosis↑, HSP70/HSPA5↓, cFLIP↓, ERK↑, p38↑,
8284- LE,    Glycyrrhizic acid from licorice down-regulates inflammatory responses via blocking MAPK and PI3K/Akt-dependent NF-κB signalling pathways in TPA-induced skin inflammation
- in-vivo, Nor, NA
*Ingr↝, *iNOS↓, *COX2/PTGS2↓, *IκB↓, *p65↓, *ERK↓, *p38↓, *MAPK↓, *PI3K↓, *Akt↓, *NF-kB↓,
2923- LT,    Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells
- in-vitro, neuroblastoma, NA
Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,
2911- LT,    Luteolin targets MKK4 to attenuate particulate matter-induced MMP-1 and inflammation in human keratinocytes
- in-vitro, Nor, HaCaT
*MMP1↓, *COX2/PTGS2↓, *IL6↓, *AP-1↓, *NF-kB↓, *ROS↓, *p‑MKK4↑, *p‑JNK↓, *p‑p38↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2917- LT,  Rad,    Luteolin acts as a radiosensitizer in non‑small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade
- in-vitro, Lung, NA
Bcl-2↓, Casp3↑, Casp8↑, Casp9↑, p‑p38↑, ROS↑, RadioS↑,
3267- Lyco,    Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways
- in-vitro, Nor, HUVECs
*VEGF↓, *MMP2↓, *uPA↓, *Rac1↑, *TIMP2↑, *p38↓, *Akt↓, *angioG↓,
3266- Lyco,    Effects of lycopene on number and function of human peripheral blood endothelial progenitor cells cultivated with high glucose
- in-vitro, Nor, NA
*p38↓, *MAPK↓,
4777- Lyco,    Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells
- in-vitro, GC, AGS
*antiOx↑, tumCV↓, DNAdam↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, ROS↓, NF-kB↓, COX2/PTGS2↓, EGFR↓, p38↓,
8521- MAG,    Magnolol induces apoptosis via caspase-independent pathways in non-small cell lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H520 - in-vitro, Lung, NCI-H441
TumCP↓, DNAdam↑, MMP↓, selectivity↑, BID↑, BAX↑, Cyt‑c↑, AIF↑, Endon↑, cl‑PARP↑, PI3K↓, Akt↓, ERK↓, p38↑, JNK↑,
4527- MAG,    Magnolol inhibits growth and induces apoptosis in esophagus cancer KYSE-150 cell lines via the MAP kinase pathway
- in-vitro, ESCC, TE1 - in-vitro, ESCC, Eca109 - vitro+vivo, SCC, KYSE150
TumCP↓, TumCMig↓, MMP2↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑p38↓, TumCG↓,
8569- Matr,    Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway
- vitro+vivo, Cerv, NA
TumCG↓, Apoptosis↑, TumCI↓, TumCMig↓, MMP2↓, MMP9↓, p38↓, TumCG↓, TumMeta↓,
8576- Matr,    Matrine reduces the proliferation and invasion of colorectal cancer cells via reducing the activity of p38 signaling pathway
- vitro+vivo, CRC, NA
TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑p38↓, TumMeta↓,
8532- Matr,    Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells
- in-vitro, NSCLC, NA
Apoptosis↑, Casp↑, p38↓, ROS↑, eff↓,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8546- Matr,    Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice
- in-vivo, Stroke, NA
*Dose?, *Stroke↓, *BBB↝, *TJ↑, *ZO-1↑, *OCLN↑, *CLDN4↑, *HMGB1↓, *RAGE↓, *JNK↓, *p38↓, *ERK↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *BAX↓, *Bcl-2↑, *Apoptosis↓, *Iron↓, *ACSL4↓, *GPx4↑, *Ferroptosis↓, *neuroP↑, *Inflam↓, *antiOx↑,
8715- MeJa,    Methyl jasmonate decreases membrane fluidity and induces apoptosis via tumor necrosis factor receptor 1 in breast cancer cells
- in-vitro, BC, MDA-MB-453 - in-vitro, BC, MCF-10AT
TumCG↓, TumCCA↑, memfluid↓, TNFR 1↑, MAPK↑, Casp8↑, MMP↓, Apoptosis↑, p38↑, ERK↑, Casp3↑,
6540- MeSal,    Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK
- in-vitro, CRC, HCT116
Apoptosis↑, p38↑, MAPK↑,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, RadioS↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
3477- MF,    Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
- Review, Var, NA
*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,
3469- MF,    Pulsed Electromagnetic Fields (PEMF)—Physiological Response and Its Potential in Trauma Treatment
- Review, Nor, NA
*eff↑, *eff↝, *other↑, Ca+2↑, ROS↑, HSP70/HSPA5↑, *NOTCH↑, *HEY1↑, *p38↑, *MAPK↑,
488- MF,    Repetitive exposure to a 60-Hz time-varying magnetic field induces DNA double-strand breaks and apoptosis in human cells
- in-vitro, Var, HeLa - in-vitro, NA, IMR90
DNAdam↑, p‑γH2AX↑, Chk2↑, p38↑, Apoptosis↑,
194- MF,    Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke
- Review, Stroke, NA
*BAD↓, *BAX↓, *Casp3↓, *Bcl-xL↑, *p‑Akt↑, *MMP9↓, *p‑ERK↑, *HIF-1↓, *ROS↓, *VEGF↑, *Ca+2↓, *SOD↑, *IL2↑, *p38↑, *HSP70/HSPA5↑, *Apoptosis↓, *ROS↓, *NO↓,
204- MFrot,  MF,    Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
- in-vivo, AD, NA
*NF-kB↓, *MAPK↓, *TLR4↓, *memory↑, *cognitive↑, *TGF-β1↑, *ARG1/2↑, *IL4↑, *IL10↑, *IL6↓, *IL1↓, *TNF-α↓, *iNOS↓, *ROS↓, *NO↓, *MyD88↓, *p‑IKKα↓, *p‑IκB↓, *p‑p65↓, *p‑JNK↓, *p‑p38↓, *ERK↓, *neuroP↑, *Aβ↓,
8681- MLT,    Melatonin changes energy metabolism and reduces oncogenic signaling in ovarian cancer cells
- in-vitro, Ovarian, SKOV3
HIF-1↓, G6PD↓, GAPDH↓, PDH↓, CS↓, PFK1↓, LDH↓, PDH↑, lactateProd↓, glut↓, CREB↓, JNK↓, NF-kB↓, p38↓, ERK↓, Akt↓, P70S6K↓, STAT↓, Warburg↓, GlutaM↓,
8612- MO,  MTX,    Lemon Balm Attenuates Methotrexate-Induced Testicular Damage Through Modulation of Oxidative Stress and p-p38 MAPK Signaling
- in-vivo, Nor, NA
*ROS↓, *Inflam↓, *p‑p38↓,
8867- MOR,  doxoR,    Morin Sensitizes MDA-MB-231 Triple-Negative Breast Cancer Cells to Doxorubicin Cytotoxicity by Suppressing FOXM1 and Attenuating EGFR/STAT3 Signaling Pathways
- in-vitro, BC, MDA-MB-231
ChemoSen↑, EPR↑, DNAdam↑, γH2AX↑, p‑EGFR↓, p‑STAT3↓, TumCCA↑, P21↑, cycD1/CCND1↓, FOXM1↓, tumCV↓, *p38↑,
1170- MushCha,    Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism
- in-vitro, Oral, HSC4
tumCV↓, TumCP↓, TumCCA↑, STAT3↓, Glycolysis↓, MMP↓, TumAuto↑, p38↑, NF-kB↑,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, Var, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2/PTGS2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, Var, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2/PTGS2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp/ABCB1↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
8424- OM,    Origanum majorana Essential Oil Triggers p38 MAPK-Mediated Protective Autophagy, Apoptosis, and Caspase-Dependent Cleavage of P70S6K in Colorectal Cancer Cells
- in-vitro, CRC, HT-29
tumCV?, mTOR↓, P70S6K↓, Casp8↑, Casp9↑, p38↑, MAPK↑,
8449- OM,    Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties
- in-vitro, BC, MDA-MB-231
antiOx↑, ROS↑, TumCP↓, TumCCA↑, p‑p38↑, P21↑, Ki-67↓, eff↓, Apoptosis↑, Casp3↑, STAT3↑, P53↑, TumCMig↓, TumCI↓, FAK↓, iNOS↓, angioG↓,
2078- PB,    Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response
- in-vitro, CRC, HCT116
p38↑, ER Stress↑, Casp3↑, Casp7↑, TumCD↑, Apoptosis↑, TumCP↑, HSP27↓,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP/DDIT3↑, AR↓, other?,
1674- PBG,  SDT,  HPT,    Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells
- in-vitro, PC, PANC1 - in-vitro, Nor, H6c7
tumCV↓, ROS↑, eff↑, Dose∅, selectivity↑, MMP↓, mtDam↑, cl‑PARP↑, p‑ERK↓, p‑JNK↑, p‑p38↑, eff↓, ChemoSen↑,
4943- PEITC,    Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation
- in-vitro, Ovarian, OVCAR-3
TumCD↑, TumCP↓, Apoptosis↑, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Akt↓, ERK↓, cMyc↓, p38↑, JNK↑, eff↓,
9016- Phyco,    Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy
- vitro+vivo, PC, PANC1 - in-vitro, PC, Capan1 - in-vitro, Liver, HepG2 - in-vitro, Lung, H460 - in-vitro, Pca, DU145
TumCP↓, TumCCA↑, Beclin-1/ATG6↑, p38↑, JNK↑, ERK↓, PI3K↓, Akt↓, mTOR↓, selectivity↑, Dose↝, toxicity↓, TumW↓, TumVol↓, TumAuto↑,
1165- PI,    Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells
- in-vitro, GC, TMK-1
p38↓, IL6↓, STAT3↓,
2970- PL,    Piperlongumine induces apoptosis and autophagy in leukemic cells through targeting the PI3K/Akt/mTOR and p38 signaling pathways
- in-vitro, AML, NA
AntiAg↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↓, mTOR↓, p38↑, Casp3↑,
2969- PL,    Piperlongumine induces autophagy by targeting p38 signaling
- in-vitro, OS, U2OS - in-vitro, Cerv, HeLa
p38↑, ROS↑, GPx1∅, SOD∅, Catalase∅,
2949- PL,    Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
selectivity↑, ROS↑, JNK↑, p38↑, GSH↓, eff↓,
2950- PL,    Overview of piperlongumine analogues and their therapeutic potential
- Review, Var, NA
AntiAg↑, neuroP↑, Inflam↓, NO↓, PGE2↓, MMP3↓, MMP13↓, TumCMig↓, TumCI↓, p38↑, JNK↑, NF-kB↑, ROS↑, FOXM1↓, TrxR1↓, GSH↓, Trx↓, cMyc↓, Casp3↑, Bcl-2↓, Mcl-1↓, STAT3↓, AR↓, DNAdam↑,
1940- PL,    Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
ROS↑, GSH↓, p38↑, JNK↑, IKKα↑, NF-kB↓, eff↓,
1946- PL,  PI,    Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling
- in-vitro, Liver, NA
eff↑, toxicity↓, TrxR↓, ROS↑, MMP↓, p38↑, Akt↓, mTOR↓,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,

Showing Research Papers: 101 to 150 of 201
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 201

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ARE↑, 1,   Catalase↓, 3,   Catalase∅, 1,   Fenton↑, 1,   GPx↓, 2,   GPx↑, 1,   GPx1∅, 1,   GPx4↓, 2,   GSH↓, 14,   GSH↑, 4,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 4,   HO-1↑, 7,   Iron↑, 2,   i-Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 3,   MDA↓, 1,   MPO↓, 1,   NADH↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 6,   NRF2↑, 7,   NRF2↝, 1,   ROS↓, 12,   ROS↑, 89,   ROS⇅, 4,   i-ROS↓, 1,   i-ROS↑, 1,   m-ROS↑, 1,   mt-ROS↑, 1,   SOD↓, 5,   SOD↑, 2,   SOD∅, 1,   SOD2↓, 1,   TBARS↓, 1,   Trx↓, 1,   Trx↑, 1,   TrxR↓, 1,   TrxR↑, 1,   TrxR1↓, 2,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR↓, 1,   CDC2↓, 4,   CDC25↓, 4,   compI↓, 1,   compIII↓, 1,   CS↓, 1,   EGF↓, 2,   ETC↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKP5↑, 1,   mtDam↑, 2,   OCR↓, 1,   OXPHOS↓, 1,   PDH↓, 1,   PDH↑, 1,   PGC-1α↑, 1,   PHB↓, 1,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ACC↑, 1,   ALDOA↓, 1,   AMPK↓, 1,   AMPK↑, 5,   ATP↓, 6,   ATP↑, 1,   ENO1↓, 1,   FASN↓, 1,   G6PD↓, 1,   GAPDH↓, 1,   GLO-I↓, 1,   glucose↓, 2,   GlucoseCon↓, 3,   glut↓, 1,   GlutaM↓, 1,   Glycolysis↓, 7,   GSK‐3β↓, 3,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   HK2↓, 1,   lactateProd↓, 5,   lactateProd↑, 1,   LDHA↓, 2,   MCT4↓, 1,   NADPH↑, 2,   NADPH↝, 1,   PCK1↓, 2,   PDK1 / PDPK1↓, 1,   p‑PDK1 / PDPK1↓, 1,   PFK1↓, 1,   PKM2↓, 3,   p‑S6↓, 1,   SCD1↓, 1,   SIRT1↓, 2,   SIRT1↑, 3,   TCA↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 6,   APAF1↑, 2,   Apoptosis↓, 2,   Apoptosis↑, 78,   mt-Apoptosis↑, 1,   ASC↓, 1,   ASK1↑, 2,   BAD↑, 3,   Bak↑, 2,   BAX↓, 1,   BAX↑, 52,   Bax:Bcl2↑, 9,   Bcl-2↓, 57,   Bcl-2↑, 3,   Bcl-xL↓, 9,   BID↓, 1,   BID↑, 3,   p‑BID↓, 1,   BIM↑, 3,   BNIP3↑, 1,   Casp↑, 15,   Casp1↓, 1,   Casp12↑, 3,   Casp3↓, 2,   Casp3↑, 53,   cl‑Casp3↑, 12,   cl‑Casp3⇅, 1,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 25,   Casp9↓, 1,   Casp9↑, 40,   cl‑Casp9↑, 4,   cFLIP↓, 3,   Cyt‑c↑, 41,   Cyt‑c↝, 1,   Diablo↑, 4,   DR5↑, 11,   Endon↑, 2,   FADD↑, 2,   Fas↑, 11,   FasL↑, 7,   Ferroptosis↑, 3,   GRP58↓, 1,   HEY1↓, 1,   IAP1↓, 4,   IAP2/BIRC3↓, 4,   ICAD↓, 1,   iNOS↓, 5,   Mcl-1↓, 11,   p‑Mcl-1↓, 1,   MDM2↓, 1,   MDM2↑, 1,   p‑MDM2↓, 1,   Necroptosis↑, 3,   necrosis↑, 1,   p38↓, 33,   p38↑, 89,   p‑p38↓, 14,   p‑p38↑, 27,   p‑p38↝, 1,   PUMA↑, 1,   RIP3↓, 1,   RIP3↑, 1,   survivin↓, 24,   TNFR 1↑, 1,   TRAIL↑, 3,   TRAILR↑, 1,   TumCD↑, 10,   XIAP↓, 12,   XIAP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 46,   Akt↑, 1,   p‑Akt↓, 16,   p‑Akt↑, 2,   AKT1↓, 1,   AMPKα↑, 1,   CK2↓, 1,   cMET↓, 3,   CREB↓, 1,   p‑CREB↓, 1,   cSrc↓, 1,   EGFR↓, 12,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 27,   ERK↑, 18,   p‑ERK↓, 19,   p‑ERK↑, 2,   p‑ERK⇅, 1,   p‑ERK↝, 1,   e-ERK↑, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 7,   HGF/c-Met↓, 1,   HRAS↓, 1,   IKKα↓, 3,   IKKα↑, 2,   IKKα↝, 1,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 2,   JAK1↓, 2,   JAK2↓, 4,   JNK↓, 10,   JNK↑, 31,   p‑JNK↓, 5,   p‑JNK↑, 11,   p‑JNK↝, 1,   MAP2K1/MEK1↓, 1,   MAPK↓, 11,   MAPK↑, 28,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 2,   MEK↓, 2,   MKK4↓, 1,   mTOR↓, 24,   mTOR↝, 1,   p‑mTOR↓, 3,   mTORC2↓, 1,   NRAS↓, 2,   p42↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 4,   PDGFR-BB↓, 1,   PI3K↓, 33,   PI3K↑, 2,   p‑PI3K↓, 2,   p‑PIK3R1↓, 1,   PKCδ↓, 4,   p‑PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 5,   Raf↓, 5,   e-Raf↓, 1,   RAS↓, 5,   RET↓, 1,   RIP1↓, 2,   RIP1↑, 1,   p‑RSK↓, 1,   Sp1/3/4↓, 3,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 26,   STAT3↑, 3,   p‑STAT3↓, 5,   p‑STAT5↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 2,   cJun↓, 4,   cJun↑, 8,   p‑cJun↑, 1,   cMyc↓, 10,   cMyc↑, 1,   DNMT1↓, 2,   EZH2↓, 1,   FOXM1↓, 3,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 4,   H3↓, 1,   H3↑, 1,   p‑H3↓, 1,   H4↓, 1,   H4↑, 1,   HDAC↓, 7,   HDAC1↓, 2,   HDAC10↑, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   miR-124-3p↓, 1,   miR-21↑, 1,   Myc↓, 2,   MYCN↓, 1,   OCT4↓, 4,   other?, 1,   other↑, 2,   other↝, 2,   SOX2↓, 5,   SOX9↓, 1,   SOX9↑, 1,   tumCV?, 1,   tumCV↓, 19,  

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑ATF6↑, 1,   CHOP/DDIT3↑, 13,   eIF2α↓, 2,   eIF2α↑, 3,   p‑eIF2α↑, 4,   ER Stress↓, 1,   ER Stress↑, 16,   GRP78/BiP↓, 2,   GRP78/BiP↑, 4,   GRP94↑, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 1,   HSP90↓, 5,   HSPs↓, 1,   HSPs↑, 1,   PERK↑, 3,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   ATG7↑, 1,   Beclin-1/ATG6↑, 11,   LC3B-II↑, 2,   LC3II↓, 1,   LC3II↑, 6,   LC3s↑, 1,   p62↓, 2,   p62↑, 1,   TumAuto↑, 16,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑BRCA1↑, 1,   DNAdam↑, 21,   DNArepair↓, 2,   hTERT/TERT↓, 1,   p16↑, 2,   P53↑, 30,   P53∅, 1,   p‑P53↑, 1,   PARP↓, 2,   PARP↑, 7,   cl‑PARP↓, 1,   cl‑PARP↑, 27,   cl‑PARP1↑, 1,   PCNA↓, 8,   Telomerase↓, 2,   TOP1↓, 3,   TOP2↓, 2,   UHRF1↓, 1,   γH2AX↑, 4,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 10,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 12,   CDK2↑, 1,   CDK4↓, 14,   p‑CDK4↓, 1,   CDK6↓, 4,   CDK6↑, 2,   CHK1↓, 2,   CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 2,   p‑Chk2↓, 1,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 21,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 4,   E2Fs↓, 1,   Ki-67↓, 9,   P21↓, 1,   P21↑, 26,   p27/CDKN1B↑, 9,   p‑pRB↓, 1,   p‑RB1↓, 2,   TumCCA↓, 1,   TumCCA↑, 53,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 2,   ALDH1A1↓, 1,   BMP2↓, 1,   CD133↓, 2,   CD24↓, 1,   CD34↓, 2,   cFos↓, 2,   cFos↑, 1,   CSCs↓, 12,   EP4/PTGER4↑, 1,   FGF↓, 1,   Gli↓, 1,   HH↓, 1,   IGF-1↓, 3,   IGFBP3↑, 2,   Jun↓, 3,   p‑Jun↑, 1,   Ki-67↓, 9,   mTORC1↓, 2,   Nanog↓, 4,   NOTCH↓, 4,   NOTCH1↓, 2,   NOTCH2↑, 1,   SCF↓, 1,   Shh↓, 1,   TumCG?, 1,   TumCG↓, 24,   TumCG↑, 1,   TumCP↓, 44,   TumCP↑, 2,   Wnt?, 1,   Wnt↓, 9,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 8,   ATPase↓, 1,   AXL↓, 2,   Ca+2↓, 2,   Ca+2↑, 17,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↓, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 1,   COL1↓, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 10,   EMMPRIN↓, 1,   EMT↓, 16,   F-actin↓, 1,   FAK↓, 11,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   LAMs↓, 2,   MALAT1↓, 1,   MET↓, 4,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP1:TIMP1↑, 1,   MMP13↓, 2,   MMP2↓, 28,   MMP3↓, 2,   MMP7↓, 5,   MMP9↓, 37,   MMPs↓, 10,   MUC4↓, 2,   N-cadherin↓, 8,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 3,   ROCK1↑, 1,   Slug↓, 5,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 1,   p‑SMAD3↓, 2,   Snail?, 1,   Snail↓, 6,   TET1↓, 1,   TGF-β↓, 6,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↑, 3,   TIMP3↑, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI↓, 24,   TumCMig↓, 24,   TumMeta↓, 21,   Twist↓, 10,   Tyro3↓, 1,   uPA↓, 12,   uPAR↓, 2,   Vim↓, 7,   Vim↑, 1,   Zeb1↓, 6,   ZEB2↓, 2,   α-SMA↓, 1,   β-catenin/ZEB1↓, 13,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   angioG↑, 1,   CD31/PECAM-1↓, 2,   EGR1↑, 1,   eNOS↓, 2,   HIF-1↓, 1,   Hif1a↓, 11,   NO↓, 2,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 35,   VEGFR2/KDR/Flk1↓, 7,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   EPR↑, 2,   GLUT1↓, 3,   GLUT4↓, 2,   memfluid↓, 1,   MMP↓, 41,   MPT↑, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   CB2 / CNR2↑, 1,   CD25+↑, 1,   CD4+↑, 1,   CD44↓, 5,   CD47↓, 1,   CD8+↑, 2,   p‑cDC2↓, 1,   COX2/PTGS2↓, 27,   CXCL1↓, 1,   CXCR4↓, 5,   FOXP3↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL10↓, 2,   IL12↓, 2,   IL1β↓, 7,   IL2↑, 2,   IL4↓, 1,   IL6↓, 13,   IL8↓, 2,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 11,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB?, 1,   NF-kB↓, 44,   NF-kB↑, 4,   NF-kB↝, 2,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 1,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 4,   RAGE↓, 1,   SOCS1↑, 1,   T-Cell↑, 1,   TLR4↓, 1,   TNF-α↓, 11,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH∅, 1,   e-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 2,   ERβ/ESR2↑, 1,   PPARγ↓, 1,   PPARγ↑, 4,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   BioAv↓, 6,   BioAv↑, 15,   BioAv↝, 2,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 36,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 1,   Dose↝, 18,   Dose∅, 1,   eff↓, 21,   eff↑, 22,   eff↝, 5,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 1,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 6,   P-gp/ABCB1↑, 1,   P450↓, 1,   RadioS↑, 10,   selectivity?, 1,   selectivity↑, 19,   selectivity↝, 1,   Synergy↑, 26,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   AR↓, 5,   BMD↑, 1,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 3,   E7↓, 3,   EGFR↓, 12,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 3,   HER2/EBBR2↓, 7,   hTERT/TERT↓, 1,   IL6↓, 13,   KRAS↓, 1,   LDH↓, 1,   LDH↑, 1,   Myc↓, 2,   NSE↓, 1,   PD-L1↓, 1,   RAGE↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 8,   AntiTum↓, 1,   AntiTum↑, 5,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 14,   chemoPv↑, 5,   ChemoSideEff↓, 1,   hepatoP↑, 8,   neuroP↑, 2,   NP/CIPN↓, 1,   Obesity↓, 1,   OS↑, 3,   Pain↓, 1,   PFS↑, 1,   QoL↑, 1,   radioP↑, 4,   RenoP↑, 3,   Risk↓, 4,   toxicity↓, 4,   toxicity↝, 3,   toxicity∅, 2,   TumVol↓, 7,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 1,  
Total Targets: 655

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 30,   ARE↑, 2,   Bil↑, 1,   Catalase↑, 15,   Fenton↓, 1,   GCLC↑, 2,   GCLM↑, 1,   GPx↑, 8,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 13,   GSR↑, 2,   GSSG↓, 1,   GSTs↑, 4,   HDL↑, 1,   HO-1↑, 10,   Iron↓, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 15,   MDA↓, 15,   MPO↓, 4,   NQO1↑, 3,   NRF2?, 1,   NRF2↑, 17,   Prx↑, 1,   RNS↓, 1,   ROS↓, 41,   ROS↑, 1,   ROS∅, 1,   SOD↑, 20,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 2,   TBARS↓, 2,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   IronCh↑, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   mtDam↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 2,   ACSL4↓, 1,   ALAT↓, 6,   AMP↓, 1,   AMPK↑, 4,   ATP↑, 2,   glucose↑, 1,   glucose↝, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   H2S↑, 1,   LDL↓, 3,   lipidLev↓, 1,   NADPH↓, 1,   NADPH↑, 3,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

APAF1↓, 1,   Apoptosis↓, 5,   BAD↓, 1,   BAX↓, 4,   Bax:Bcl2↑, 1,   Bcl-2↑, 3,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 5,   cl‑Casp3↓, 1,   Casp9↓, 3,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   HEY1↑, 1,   iNOS↓, 11,   necrosis↓, 1,   p38↓, 21,   p38↑, 7,   p‑p38↓, 14,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 6,   Akt↝, 1,   p‑Akt↓, 1,   p‑Akt↑, 2,   Akt2↓, 1,   EGFR↓, 1,   ERK↓, 5,   ERK↑, 3,   p‑ERK↓, 6,   p‑ERK↑, 1,   IKKα↓, 1,   p‑IKKα↓, 2,   IκB↓, 1,   p‑IκB↓, 1,   JAK2↑, 1,   JNK↓, 11,   p‑JNK↓, 9,   MAPK↓, 11,   MAPK↑, 4,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MKK4↑, 1,   Mst1↓, 1,   mTOR↓, 1,   PI3K↓, 2,   PI3K↑, 4,   PKCδ↑, 1,   PTEN↓, 1,   STAT3↑, 1,   STAT3↝, 1,   STAT4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   p‑cJun↓, 2,   FOXO↑, 1,   FOXO3↑, 1,   other↑, 3,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 2,   γH2AX↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

NOTCH↑, 1,   STAT1↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 2,   ARG1/2↑, 1,   Ca+2↓, 2,   Ca+2↑, 2,   FAK↑, 1,   heparanase↑, 1,   MLC2/MYL9↝, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 2,   Rac1↑, 1,   TGF-β↓, 1,   TGF-β↑, 2,   TGF-β1↑, 1,   TIMP2↑, 1,   uPA↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   E-sel↓, 1,   eNOS↑, 1,   HIF-1↓, 1,   NO↓, 6,   NO↑, 1,   VCAM-1↓, 3,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 4,   BBB↝, 1,   CLDN4↑, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT4↑, 1,   IBI↑, 1,   MMP↓, 1,   MMP↑, 3,   MUC5AC↓, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 2,   TRPA1↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 14,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL10↑, 3,   IL17↓, 1,   IL1β↓, 15,   IL2↑, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 17,   IL8↓, 3,   Imm↑, 1,   Inflam↓, 34,   LPS↓, 1,   MyD88↓, 1,   NF-kB↓, 27,   p‑NF-kB↓, 1,   NLRP3↓, 6,   p‑p50↓, 1,   p65↓, 1,   p‑p65↓, 2,   PGE2↓, 5,   PGE2↑, 1,   RAGE↓, 2,   Th1 response↓, 2,   Th17↓, 1,   Th2↑, 2,   TLR4↓, 2,   TNF-α↓, 23,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   ADAM10↑, 1,   BChE↓, 2,   BDNF↑, 3,   ChAT↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 8,   BACE/β-secretase↓, 3,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↑, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 4,   BioAv↝, 5,   BioEnh↑, 1,   Dose?, 1,   Dose↑, 1,   Dose↝, 6,   eff↓, 1,   eff↑, 4,   eff↝, 1,   GSTA1↑, 3,   Half-Life↓, 1,   Half-Life↝, 6,   P450↑, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 1,   AST↓, 6,   BG↓, 1,   Bil↑, 1,   BMD↑, 1,   BP↓, 1,   BUN↓, 1,   creat↓, 2,   CRP↓, 1,   EGFR↓, 1,   hs-CRP↓, 1,   IL6↓, 17,   LDH↓, 4,   RAGE↓, 2,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 2,   antiAll↑, 10,   AntiArt↑, 3,   AntiCan↑, 5,   AntiDiabetic↑, 2,   antiPs↑, 1,   cardioP↑, 15,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 12,   hepatoP↑, 14,   memory↑, 9,   motorD↓, 1,   motorD↑, 1,   neuroP↑, 25,   Obesity↓, 2,   Pain↓, 1,   radioP↑, 6,   RenoP↑, 3,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 2,   toxicity?, 1,   toxicity↓, 6,   toxicity↝, 2,   toxicity∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   AntiP↑, 1,   AntiViral↑, 5,   Bacteria↓, 6,   GutMicro↑, 8,   Inf↓, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 6,  
Total Targets: 299

Scientific Paper Hit Count for: p38, p38
10 Thymoquinone
8 Allicin (mainly Garlic)
8 Fisetin
8 Quercetin
6 Sulforaphane (mainly Broccoli)
6 Magnetic Fields
6 Piperlongumine
6 Silymarin (Milk Thistle) silibinin
6 Shikonin
5 Berberine
5 Resveratrol
5 Matrine
4 Silver-NanoParticles
4 Radiotherapy/Radiation
4 Artemisinin
4 Curcumin
4 Hydrogen Gas
4 Luteolin
4 Vitamin K2
3 Apigenin (mainly Parsley)
3 Betulinic acid
3 Chrysin
3 Hibiscus sabdariffa
3 Juglone
3 Licochalcone A
3 Lycopene
2 1,8-Cineole
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Beta-Caryophyllene
2 Boswellia (frankincense)
2 Caffeic acid
2 Carnosic acid
2 Carvacrol
2 Crocetin
2 Ginger/6-Shogaol/Gingerol
2 EGCG (Epigallocatechin Gallate)
2 5-fluorouracil
2 doxorubicin
2 Genistein (soy isoflavone)
2 Isoliquiritigenin
2 isoorientin
2 Phenethyl isothiocyanate
2 Kaempferol
2 Magnolol
2 Marjoram (Origanum majorana)
2 Phenylbutyrate
2 Piperine
2 Vitamin C (Ascorbic Acid)
1 Photodynamic Therapy
1 Camptothecin
1 alpha Linolenic acid
1 Ascorbyl Palmitate
1 Trastuzumab
1 Black Rice, Oryza sativa
1 α-Bisabolol / Chamomile oil
1 Capsaicin
1 Chlorogenic acid
1 Carvone
1 Diindolylmethane
1 D-limonene
1 Disulfiram
1 Eurycomanone
1 Eugenol
1 Evodiamine
1 Ferulic acid
1 Formononetin
1 Flaxseed/Linseed
1 Gambogic Acid
1 Ginkgo biloba
1 Ginkgolide B
1 Grapeseed extract
1 Hyperoside
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Lasiodin
1 Licorice
1 Methyl Jasmonate
1 Methyl salicylate / Sweet Birch oil
1 Magnetic Field Rotating
1 Melatonin
1 Lemon Balm/Melissa officinalis
1 methotrexate
1 Morin
1 Mushroom Chaga, Inonotus obliquus
1 Myricetin
1 Naringin
1 Propolis -bee glue
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Phycocyanin
1 raloxifen
1 tamoxifen
1 Rosmarinic acid
1 Rutin
1 buckwheat sprouts
1 Sanguinarine
1 Selenium
1 Oxygen, Hyperbaric
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Urolithin
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:235  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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