P53 Cancer Research Results

P53, P53-Guardian of the Genome: Click to Expand ⟱
Source: TCGA
Type: Proapototic
TP53 is the most commonly mutated gene in human cancer. TP53 is a gene that encodes for the p53 tumor suppressor protein ; TP73 (Chr.1p36.33) and TP63 (Chr.3q28) genes that encode transcription factors p73 and p63, respectively, are TP53 homologous structures.
p53 is a crucial tumor suppressor protein that plays a significant role in regulating the cell cycle, maintaining genomic stability, and preventing tumor formation. It is often referred to as the "guardian of the genome" due to its role in protecting cells from DNA damage and stress.
TP53 gene, which encodes the p53 protein, is one of the most frequently mutated genes in human cancers.
Overexpression of MDM2, an inhibitor of p53, can lead to decreased p53 activity even in the presence of wild-type p53.
In some cancers, particularly those with mutant p53, there may be an overexpression of the p53 protein.
Cancers with overexpression: Breast, lung, colorectal, overian, head and neck, Esophageal, bladder, pancreatic, and liver.
Scientific Papers found: Click to Expand⟱
748- Bor,    A Study on the Anticarcinogenic Effects of Calcium Fructoborate
- in-vitro, BC, MDA-MB-231
p‑ATM↑, p‑P53↑, Casp9↑, PARP↓, VEGF↓, Casp3↑,
749- Bor,    Comparative effects of boric acid and calcium fructoborate on breast cancer cells
P53↓, Bcl-2↓, Casp3↑, Apoptosis↑,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
5694- BRU,    Brusatol overcomes chemoresistance through inhibition of protein translation
- in-vitro, Lung, A549
NRF2↓, P53↓, P21↓,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
5877- CA,    Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells
- in-vitro, CRC, HCT116
tumCV↓, Apoptosis↑, Casp9↑, Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↓, MDM2↓, ROS↑, eff↓, STAT3↓, survivin↓, cycD1/CCND1↓,
5866- CA,    Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells
- in-vitro, CRC, HCT116 - in-vitro, Colon, SW480 - in-vitro, Colon, HT29
tumCV↓, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cycD1/CCND1↓, CycD3↓, ROS↑, eff↓, eff↑,
5833- CAP,    Capsaicin: From Plants to a Cancer-Suppressing Agent
- Review, Var, NA
chemoPv↑, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Ca+2↑, JNK↑, Casp3↑, NADH↓, CDK2↓, CDK4↓, CDK6↓, P53↑,
5861- CAP,    Anticancer Properties of Capsaicin Against Human Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Obesity↓, chemoPv↑, Apoptosis↑, selectivity↑, TRPV1↑, Ca+2↑, mtDam↑, Cyt‑c↑, P53↑, SIRT1↓, TumCCA↑, P21↑, CDK4↓, CDK6↓, cycE/CCNE↓, angioG↓, TumMeta↓,
5849- CAP,    The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review
- Review, Var, NA
TRPV1↑, Ca+2↑, TumCD↑, TumCCA↑, Apoptosis↑, P53↑, Fas↑, PI3K↑, AR↑, STAT3↓, ROS↑, MMP↓, ATP↓, CHOP↑, TumCMig↓, Twist↓, Snail↓, MMP2↓, MMP9↓, E-cadherin↑,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp↓, ChemoSen↑,
5843- CAP,    The Effects of Capsaicin on Gastrointestinal Cancers
- Review, GC, NA
*BioAv↑, ROS↑, Apoptosis↑, Glycolysis↓, HK2↓, MMP9↓, AMPK↑, TumCP↓, Casp3↑, Bcl-2↓, P53↑, BAX↑,
1517- CAP,    Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)
- in-vitro, Bladder, TSGH8301 - in-vitro, CRC, T24/HTB-9
ENOX2↓, TumCCA↑, ERK↓, p‑FAK↓, p‑pax↓, TumCMig↓, EMT↓, SIRT1↓, Dose∅, ROS↑, MMP↓, Bcl-2↓, Bak↑, cl‑PARP↑, Casp3↑, SIRT1↓, ac‑P53↑, BIM↑, p‑RB1↓, cycD1/CCND1↓, Dose∅, β-catenin/ZEB1↓, N-cadherin↓, E-cadherin↑,
2012- CAP,    Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways
- NA, OS, MG63
AntiTum↑, Apoptosis↑, TRPV1↑, ROS↑, SOD↓, AMPK↑, P53↑, JNK↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Ca+2↑, MMP↓,
2013- CAP,    Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vivo, NA, NA
TumCP↓, P53↑, P21↑, BAX↑, PSA↓, AR↓, NF-kB↓, Proteasome↓, TumVol↓, eff∅,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
5763- CAPE,    Synthesis and Biological Evaluation of a Caffeic Acid Phenethyl Ester Derivatives as Anti-Hepatocellular Carcinoma Agents via Inhibition of Mitochondrial Respiration and Disruption of Cellular Metabolism
- NA, HCC, NA
*antiOx↑, *neuroP↑, NF-kB↓, TumCG↓, TumMeta↓, MMPs↓, P53↑, ChemoSen↑,
5757- CAPE,    Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application
- Review, Nor, NA
*NF-kB↓, NF-kB↓, P53↑, FOXO↑, Wnt↓, TumCI↓, *HO-1↑, MMP9↓, MMP2↓, COX1↓, COX2↓, 5LO↓,
5898- CAR,    Carvacrol-induced apoptosis via tumor suppressor gene activation and oxidative stress modulation in a rat model of breast cancer
- in-vivo, BC, NA
*lipid-P↓, *MDA↓, *antiOx↑, *Inflam↑, RenoP↑, hepatoP↑, *ALAT↓, AST↓, creat↓, chemoPv↑, Cyt‑c↑, FADD↑, P53↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5938- Cela,    Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application
- Review, Var, NA
AntiCan↑, BioAv↓, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, angioG↓, Inflam↓, antiOx↑, ChemoSen↑, HSP90↓, ROS↑, RadioS↑, P53↑, NLRP3↓,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *eff↑, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6007- CGA,    A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer
- Review, CRC, NA
antiOx↑, TumCCA↑, Apoptosis↑, Wnt↝, PI3K↝, MAPK↝, ROS↓, BioAv↝, P53↑, P21↑, CDK1↑, Ki-67↓, Ca+2↑, p‑Akt↓, mTOR↓, GSH↑, NRF2↑, HO-1↑, COX2↓, TNF-α↓, IL1β↓, IL6↓,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6138- CHr,  Cisplatin,    Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: Probable role of p38MAPK and p53
- in-vivo, Nor, NA
*toxicity↝, eff↑, chemoP↑, *ROS↓, *MAPK↑, *P53↑, GSH↓,
2795- CHr,    Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53
- in-vitro, Liver, HepG2
ChemoSen↑, P53↑, ERK↑, BAX↑, DR5↑, Bcl-2↓, Casp8↑, Cyt‑c↑, Casp9↑,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27↑, P53↑,
6164- Cin,    Advances in pharmacological effects and mechanism of action of cinnamaldehyde
- Review, Var, NA - Review, PSA, NA
*glucose↑, *cardioP↑, *Inflam↓, *lipid-P↓, GutMicro↑, TumCP↓, Apoptosis↑, TumCI↓, TumCMig↓, BAX↑, P53↑, Bcl-2↓, IAP1↓, PI3K↓, Akt↓, *ROS↓, *NRF2↑, *NF-kB↓, NF-kB↑,
6314- Cro,    Crocin promotes ferroptosis in gastric cancer via the Nrf2/GGTLC2 pathway
- in-vitro, GC, NA
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↓, antiOx↓, Ferroptosis↑, NRF2↑, P53↑, TumCCA↑, ChemoSen↑, EMT↓, Hif1a↓, ROS↑,
6308- Cro,    Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage
- vitro+vivo, PC, Bxpc-3
Bcl-2↓, Apoptosis↑, Cyt‑c↑, TumCG↓, radioP↑, TumCCA↑, TumCP↓, DNAdam↑, TBARS↓, P53↑, p38↑, CDK2↓, cMyc↓, *MDA↓, GSH↑,
6176- Cu,    Copper Oxide Nanoparticles Induced Mitochondria Mediated Apoptosis in Human Hepatocarcinoma Cells
- in-vitro, Liver, HepG2
ROS↑, P53↑, MMP↓, Bax:Bcl2↑, Apoptosis↑, *Bacteria↓, MDA↑, GSH↓, eff↓, Casp3↑,
6197- Cuc,    Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH‑SY5Y human neuroblastoma cells
- in-vitro, neuroblastoma, SH-SY5Y
TumCCA↑, Apoptosis↑, p‑JAK3↓, p‑STAT3↓, P53↑, P21↑,
6201- Cuc,    Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities
- Review, Var, NA - Review, AD, NA
*toxicity↑, *antiOx↑, *Inflam↓, *NLRP3↓, *NF-kB↓, *neuroP↑, *memory↑, *GABA↑, *cardioP↑, AntiTum↑, p‑FAK↓, ROS↑, TumMeta↑, TumCP↓, Apoptosis↑, P53↑, P21↑, TumCCA↑, p27↑, CDK4↓, CDK2↓, cycD1/CCND1↓, cycE/CCNE↓, STAT3↓, ChemoSen↑, MMP2↓, MMP9↓, VEGF↓, TumCMig↓, angioG↓, NOTCH↓, EMT↓, toxicity↑, BioAv↑, EPR↑,
6227- CUR,    Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, JAK↓, STAT3↓, MAPK↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, GSK‐3β↓, cMyc↓, survivin↓, Axin2↑, TumCCA↑, PTEN↑, P53↑, ROS↑, Casp3↑, PARP↑, Ferroptosis↑, angioG↓, TumCI↓, TumMeta↓, BioAv↓, Half-Life↓, ChemoSen↑,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *eff↑, eff↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
6212- CUR,  Rad,    Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers
- Review, Var, NA
RadioS↑, *radioP↑, EGFR↓, TGF-β↓, ROS↑, P53↑, PI3K↓, NF-kB↓, COX2↓, EMT↓, Hif1a↓, HSP90↓, mTOR↓, *Catalase↑, *SOD↑, *MDA↑, *Wound Healing↑, *hepatoP↑, *NF-kB↓, *ROS↓,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1↓, Beclin-1↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
6050- CUR,  SeNPs,    Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *AChE↓, *Aβ↓, *P53↓, *tau↓, *NRF2↓, *TNF-α↓, *NO↑, *Catalase↑, *antiOx↑, *Inflam↓,
4831- CUR,    The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity
- in-vitro, NA, NA
*NRF2↑, *P53↓, *NF-kB↓, ROS↑, Inflam↓, ChemoSen↑,
2308- CUR,    Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells
- in-vitro, Liver, HepG2
GlucoseCon↓, lactateProd↓, ECAR↓, NO↓, ROS↑, HK2↓, PFK1↓, GAPDH↓, PKM2↓, LDHA↓, FASN↓, GLUT1↓, MCT1↓, MCT4↓, HCAR1↓, SDH↑, ChemoSen↑, ROS↑, BioAv↑, P53↑, NF-kB↓, pH↑,
2974- CUR,    Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT15 - in-vitro, CRC, COLO205 - in-vitro, CRC, SW-620 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumCG↓, TumMeta↓, Sp1/3/4↓, HDAC4↓, FAK↓, CD24↓, E-cadherin↑, EMT↓, TumCP↓, NF-kB↓, AP-1↝, STAT3↓, P53?, β-catenin/ZEB1↓, NOTCH1↝, Hif1a↝, PPARα↝, Rho↓, MMP2↓, MMP9↓,
1609- CUR,  EA,    Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells
- in-vitro, Cerv, NA
eff↑, Dose∅, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑, Dose∅,
462- CUR,    Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress
- in-vitro, Pca, PC3
Bcl-2↓, MMP↓, cl‑Casp3↑, BAX↑, BIM↑, p‑PARP↑, PUMA↑, p‑P53↑, ROS↑, p‑ERK↑, p‑eIF2α↑, CHOP↑, ATF4↑,
477- CUR,    Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells
- in-vitro, Cerv, SiHa
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, CycB/CCNB1↓, CDC25↓, ROS↑, p62↑, LC3‑Ⅱ/LC3‑Ⅰ↑, cl‑Casp3↑, cl‑PARP↑, P53↑, P21↑,
457- CUR,    Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
TumCP↓, Apoptosis↑, TumAuto↑, P53↑, PI3K↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, Bcl-xL↓, LC3I↓, BAX↑, Beclin-1↑, cl‑Casp3↑, cl‑PARP↑, LC3II↑, ATG3↑, ATG5↑,
424- CUR,    Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Src↓, p‑STAT1↓, p‑Akt↓, p‑p44↓, p‑p42↓, RAS↓, Raf↓, Vim↓, β-catenin/ZEB1↓, P53↓, Bcl-2↓, Mcl-1↓, PIAS-3↑, SOCS-3↑, SOCS1↑, ROS↑, NF-kB↓, PAO↑, SSAT↑, P21↑, Bak↑,
454- CUR,    Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway
- in-vitro, GC, MGC803
TumCMig↓, TumCP↓, ROS↑, mtDam↑, DNAdam↑, Apoptosis↑, ATR↑, P21↑, p‑P53↑, GADD45A↑, p‑γH2AX↑,

Showing Research Papers: 101 to 150 of 374
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 374

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↑, 1,   ENOX2↓, 1,   Fenton↑, 1,   Ferroptosis↑, 3,   GPx4↓, 1,   GSH↓, 5,   GSH↑, 2,   HO-1↑, 4,   Iron↑, 1,   lipid-P↑, 1,   MDA↑, 2,   NADH↓, 2,   NRF2↓, 2,   NRF2↑, 6,   OXPHOS↓, 1,   PAO↑, 1,   Prx↓, 1,   ROS↓, 1,   ROS↑, 28,   SOD↓, 1,   TBARS↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   BOK↑, 1,   CDC25↓, 1,   ETC↓, 1,   mitResp↓, 1,   MMP↓, 10,   mtDam↑, 3,   p‑p42↓, 1,   Raf↓, 1,   SDH↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 7,   cMyc↓, 4,   ECAR↓, 1,   FASN↓, 2,   G6PD↓, 1,   GAPDH↓, 1,   GLS↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 4,   HK2↓, 3,   lactateProd↓, 1,   lactateProd↑, 1,   LDHA↓, 2,   MCT4↓, 1,   PDK1↓, 2,   PFK1↓, 1,   PKM2↓, 2,   PPARα↝, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 1,   SREBP2↓, 1,   SSAT↑, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 9,   Akt↑, 1,   p‑Akt↓, 4,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 28,   BAD↓, 1,   Bak↑, 2,   BAX↑, 15,   Bax:Bcl2↑, 4,   Bcl-2↓, 17,   Bcl-xL↓, 3,   BID↑, 1,   BIM↑, 2,   Casp↑, 3,   Casp3↑, 14,   cl‑Casp3↑, 4,   Casp7↑, 2,   Casp8↑, 3,   Casp9↑, 8,   Cyt‑c↑, 7,   DR5↑, 1,   FADD↑, 3,   Fap1↓, 1,   Fas↑, 4,   FasL↑, 1,   Ferroptosis↑, 3,   IAP1↓, 1,   iNOS↓, 2,   JNK↑, 5,   MAPK↓, 1,   MAPK↑, 2,   MAPK↝, 1,   Mcl-1↓, 2,   MCT1↓, 2,   MDM2↓, 2,   NAIP↓, 1,   p27↑, 2,   p38↑, 2,   Proteasome↓, 1,   PUMA↑, 1,   survivin↓, 5,   TRAIL↑, 1,   TRPV1↑, 4,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 2,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   other↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 2,   HSP90↓, 3,  

Autophagy & Lysosomes ⓘ

ATG3↑, 1,   ATG5↑, 2,   Beclin-1↓, 1,   Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3I↓, 1,   LC3II↑, 3,   p62↓, 1,   p62↑, 2,   TumAuto↑, 4,  

DNA Damage & Repair ⓘ

p‑ATM↑, 1,   ATR↑, 1,   DNAdam↑, 5,   DNMTs↓, 1,   GADD45A↑, 1,   P53?, 1,   P53↓, 4,   P53↑, 37,   p‑P53↑, 4,   ac‑P53↑, 1,   PARP↓, 1,   PARP↑, 2,   p‑PARP↑, 1,   cl‑PARP↑, 8,   PCNA↓, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↑, 1,   CDK2↓, 5,   CDK4↓, 6,   CDK4↑, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 7,   CycD3↓, 1,   cycE/CCNE↓, 3,   cycE1↓, 1,   P21↓, 2,   P21↑, 13,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 17,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   Axin2↑, 1,   CD133↑, 1,   CD24↓, 1,   CD44↓, 1,   cFos↓, 1,   CSCs↓, 3,   EMT↓, 7,   EMT↝, 1,   ERK↓, 2,   ERK↑, 2,   p‑ERK↑, 1,   FOXO↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   HDAC4↓, 1,   HDAC8↓, 1,   mTOR↓, 7,   p‑mTOR↓, 1,   Nanog↓, 1,   NOTCH↓, 2,   NOTCH1↝, 1,   OCT4↓, 1,   PI3K↓, 7,   PI3K↑, 1,   PI3K↝, 1,   PIAS-3↑, 1,   PTEN↑, 1,   RAS↓, 1,   SCF↓, 1,   SOX2↓, 1,   Src↓, 1,   STAT↓, 1,   p‑STAT1↓, 1,   STAT3↓, 9,   p‑STAT3↓, 1,   TumCG↓, 6,   Wnt↓, 3,   Wnt↝, 1,  

Migration ⓘ

5LO↓, 2,   AP-1↓, 1,   AP-1↝, 1,   Ca+2↑, 7,   i-Ca+2?, 1,   E-cadherin↑, 6,   FAK↓, 1,   p‑FAK↓, 2,   Ki-67↓, 2,   MMP2↓, 5,   MMP9↓, 9,   MMPs↓, 2,   N-cadherin↓, 3,   p‑p44↓, 1,   p‑pax↓, 1,   PKCδ↓, 1,   Rho↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP2↑, 1,   TIMP3↑, 1,   TSP-1↑, 1,   TumCI↓, 10,   TumCMig↓, 11,   TumCP↓, 15,   TumMeta↓, 12,   TumMeta↑, 2,   Twist↓, 1,   Vim↓, 2,   ZEB2↓, 1,   β-catenin/ZEB1↓, 7,  

Angiogenesis & Vasculature ⓘ

angioG↓, 9,   angioG↑, 1,   ATF4↑, 1,   EGFR↓, 2,   EPR↑, 1,   Hif1a↓, 5,   Hif1a↑, 1,   Hif1a↝, 1,   NO↓, 1,   VEGF↓, 9,  

Barriers & Transport ⓘ

GLUT1↓, 2,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 7,   CXCR4↓, 1,   HCAR1↓, 1,   IL1↓, 2,   IL10↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL2↓, 2,   IL4↓, 1,   IL6↓, 4,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 3,   JAK↓, 2,   p‑JAK3↓, 1,   MCP1↓, 1,   NF-kB↓, 12,   NF-kB↑, 1,   NK cell↑, 1,   PSA↓, 1,   SOCS-3↑, 1,   SOCS1↑, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Cellular Microenvironment ⓘ

pH↑, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   AR↑, 1,   CDK6↓, 2,   CDK6↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 1,   ChemoSen↑, 16,   Dose↝, 1,   Dose∅, 5,   eff↓, 5,   eff↑, 13,   eff↝, 1,   eff∅, 1,   Half-Life↓, 1,   RadioS↑, 2,   selectivity↑, 5,  

Clinical Biomarkers ⓘ

AFP↓, 1,   AR↓, 1,   AR↑, 1,   AST↓, 1,   creat↓, 1,   EGFR↓, 2,   GutMicro↑, 2,   IL6↓, 4,   Ki-67↓, 2,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 3,   chemoP↑, 1,   chemoPv↑, 7,   hepatoP↑, 2,   NDRG1↑, 1,   OS↑, 2,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↑, 1,   TumVol↓, 1,  
Total Targets: 304

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 7,   Catalase↑, 7,   GPx↑, 5,   GSH↑, 3,   GSR↑, 2,   GSTs↑, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 4,   Keap1↓, 1,   lipid-P↓, 4,   MDA↓, 5,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 7,   ROS↓, 10,   SOD↑, 6,   SOD1↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP∅, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   AMPK↑, 2,   glucose↓, 2,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 1,   GLUT2↑, 2,   HMG-CoA↓, 1,   LDH↓, 2,   NADPH↑, 1,   PPARα↝, 1,  

Cell Death ⓘ

Casp↓, 1,   Casp3↓, 1,   Casp3∅, 1,   Casp9↓, 1,   Cyt‑c∅, 1,   Fas↓, 1,   HGF/c-Met↑, 1,   iNOS↓, 3,   JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,  

DNA Damage & Repair ⓘ

P53↓, 2,   P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,  

Migration ⓘ

Ca+2↓, 1,   TRPC1↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   NO↑, 1,  

Barriers & Transport ⓘ

GLUT3↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 5,   CRP↓, 1,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 10,   Inflam↑, 1,   NF-kB↓, 10,   PGE2↓, 1,   TLR4↓, 3,   TNF-α↓, 4,  

Synaptic & Neurotransmission ⓘ

AChE↓, 3,   GABA↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 2,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   eff↑, 3,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 1,   BMD↑, 1,   BP↓, 1,   CRP↓, 1,   GutMicro↑, 1,   IL6↓, 2,   LDH↓, 2,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 3,   cognitive↓, 1,   cognitive↑, 1,   hepatoP↑, 3,   memory↑, 2,   neuroP↑, 7,   Obesity↓, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 97

Scientific Paper Hit Count for: P53, P53-Guardian of the Genome
29 Silver-NanoParticles
20 Thymoquinone
18 Curcumin
17 Quercetin
15 Apigenin (mainly Parsley)
11 Fisetin
10 EGCG (Epigallocatechin Gallate)
10 Resveratrol
9 Magnetic Fields
9 Propolis -bee glue
9 Capsaicin
9 Phenethyl isothiocyanate
8 Lycopene
8 Shikonin
7 Silymarin (Milk Thistle) silibinin
7 Allicin (mainly Garlic)
7 Ashwagandha(Withaferin A)
7 Baicalein
7 Berberine
7 Urolithin
6 Alpha-Lipoic-Acid
6 Radiotherapy/Radiation
6 Eugenol
5 Cisplatin
5 Ellagic acid
5 Ursolic acid
5 Emodin
5 Sulforaphane (mainly Broccoli)
4 Bromelain
4 Chrysin
4 Selenium NanoParticles
4 Dandelion Root
4 Luteolin
4 salinomycin
3 Metformin
3 Boron
3 Chlorogenic acid
3 D-limonene
3 Ferulic acid
3 Gambogic Acid
3 Magnolol
3 Magnetic Field Rotating
3 Aflavin-3,3′-digallate
2 Gemcitabine (Gemzar)
2 Anethole/trans-Anethole
2 Artemisinin
2 Astaxanthin
2 Berbamine
2 Betulinic acid
2 Brucea javanica
2 brusatol
2 Carnosic acid
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Carvacrol
2 Celastrol
2 Crocetin
2 Cucurbitacin
2 Docetaxel
2 Dichloroacetate
2 Fenbendazole
2 Gallic acid
2 Graviola
2 Honokiol
2 HydroxyTyrosol
2 Juglone
2 Oleuropein
2 Piperine
2 Piperlongumine
2 Parthenolide
2 Pterostilbene
2 Selenite (Sodium)
2 Vitamin C (Ascorbic Acid)
2 VitK3,menadione
1 Astragalus
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Camptothecin
1 tamoxifen
1 alpha Linolenic acid
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 Aloe anthraquinones
1 epirubicin
1 Biochanin A
1 borneol
1 Boswellia (frankincense)
1 Bruteridin(bergamot juice)
1 Caffeic acid
1 Cinnamon
1 Copper and Cu NanoParticles
1 Date Fruit Extract
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Vitamin A, Retinoic Acid
1 Genistein (soy isoflavone)
1 Exercise
1 Paclitaxel
1 carboplatin
1 Garcinol
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Melatonin
1 Mushroom Lion’s Mane
1 Naringin
1 Niclosamide (Niclocide)
1 Nimbolide
1 Oxygen, Hyperbaric
1 Phenylbutyrate
1 Propyl gallate
1 Plumbagin
1 Psoralidin
1 Rosmarinic acid
1 Selenium
1 irinotecan
1 doxorubicin
1 Oxaliplatin
1 Vitamin K2
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:236  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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