PGE2 Cancer Research Results

PGE2, Prostaglandin E2: Click to Expand ⟱
Source:
Type:
Prostaglandin E2 (PGE2) is a lipid compound that plays a significant role in various physiological processes, including inflammation, immune response, and regulation of cell growth. PGE2 is often found at elevated levels in various types of cancer, including colorectal, breast, and lung cancers. It can promote tumor growth by enhancing cell proliferation, inhibiting apoptosis (programmed cell death), and promoting angiogenesis (the formation of new blood vessels).
- PGE2 is a pain-inducing factor. It is able to sensitize primary sensory neurons and leads to central sensitization and also facilitate the release of pain-related neuropeptides
-Upregulated in AD brain; promotes inflammatory cytokine release, increase ROS, may increase Aβ deposition
Scientific Papers found: Click to Expand⟱
3404- TQ,    The Neuroprotective Effects of Thymoquinone: A Review
- Review, Var, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *TNF-α↓, *IL6↓, *IL1β↓, *NF-kB↓, *iNOS↓, *NRF2↑, *neuroP↑, *MMP↑, *ROS↓, *MDA↓, *GSH↑, *Catalase↑, *SOD↑, *IL12↓, *MCP1↓, *IP-10/CXCL-10↓, *PGE2↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
1218- VitC,  ASA,    Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production
- in-vitro, GBM, SK-N-SH
PGE2↓, COX2↓,
1223- VitD3,    Vitamin D3 Treatment Influences PGE2 and TGFβ in Normal and Increased Breast Cancer Risk Women
- Trial, NA, NA
*TGF-β↑, *PGE2↓,
2427- Wog,    Anti-cancer natural products isolated from chinese medicinal herbs
- Review, Var, NA
NO↓, PGE2↓, COX2↓, Ca+2↑, mtDam↑, *toxicity↓, eff↑, eff↓,

Showing Research Papers: 101 to 105 of 105
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 105

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS⇅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↑, 1,   Casp3↑, 1,   Casp7↑, 1,   Casp9↑, 1,   JNK↑, 1,   p27↑, 1,   p38↑, 1,   survivin↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   ERK↓, 1,   GSK‐3β↓, 1,   mTOR↓, 1,   PI3K↓, 1,   PTEN↑, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↓, 1,   MMPs↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   Twist↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   NO↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 2,   p‑NF-kB↑, 1,   PGE2↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↓, 1,   eff↑, 1,   selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoP↑, 1,  
Total Targets: 44

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 2,   GPx↑, 1,   GSH↑, 1,   GSTA1↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Migration(tgid=13) ⓘ

MMP13↓, 1,   TGF-β↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 2,   IP-10/CXCL-10↓, 1,   MCP1↓, 1,   NF-kB↓, 1,   PGE2↓, 3,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 29

Scientific Paper Hit Count for: PGE2, Prostaglandin E2
6 Curcumin
6 Fisetin
6 Lycopene
5 Honokiol
5 Thymoquinone
4 Magnetic Fields
4 Piperine
4 Silymarin (Milk Thistle) silibinin
3 Aspirin
3 Baicalein
3 Berberine
3 Boswellia (frankincense)
3 Chrysin
3 Eugenol
3 Rosmarinic acid
2 1,8-Cineole
2 Artemisinin
2 Betulinic acid
2 Carvacrol
2 Chocolate
2 Diclofenac
2 Echinacea
2 Ferulic acid
2 Propolis -bee glue
2 Piperlongumine
2 Resveratrol
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Apigenin (mainly Parsley)
1 Astaxanthin
1 Baicalin
1 Biochanin A
1 Boron
1 Capsaicin
1 Celecoxib
1 Celastrol
1 Chlorogenic acid
1 Lecithin
1 Docosahexaenoic Acid
1 eicosapentaenoic acid
1 Emodin
1 Shilajit/Fulvic Acid
1 Garcinol
1 Grapeseed extract
1 Proanthocyanidins
1 Luteolin
1 Magnolol
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Sesame seeds and Oil
1 Terpinen-4-ol / Tea Tree Oil
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:248  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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