PTEN Cancer Research Results

PTEN, phosphatase and tensin homolog; phosphatase and tensin homolog pseudogene 1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
PTEN (Phosphatase and Tensin Homolog) is a crucial tumor suppressor gene that plays a significant role in regulating cell growth, proliferation, and survival. It encodes a protein that functions as a phosphatase, which means it removes phosphate groups from specific molecules, thereby regulating various signaling pathways, particularly the PI3K/AKT pathway.
PTEN is mutated, deleted, or otherwise inactivated. This loss of function can lead to increased cell proliferation and survival, contributing to tumorigenesis. PTEN mutations are commonly found in various cancers, including:
Prostate cancer
Breast cancer
Endometrial cancer
Glioblastoma
Scientific Papers found: Click to Expand⟱
4862- Uro,    Neuroprotective effect of Urolithin A via downregulating VDAC1-mediated autophagy in Alzheimer's disease
- in-vivo, AD, NA - in-vitro, Nor, PC12
*cognitive↑, *p‑PI3K↓, *p‑Akt↓, *AMPK↑, *VDAC1↓, *neuroP↑, *PARK2↑, *PTEN↑, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p62↓, *Aβ↓, *Apoptosis↓,

Showing Research Papers: 101 to 101 of 101
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 101

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

PARK2↑, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑PI3K↓, 1,   PTEN↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   neuroP↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: PTEN, phosphatase and tensin homolog; phosphatase and tensin homolog pseudogene 1
9 Thymoquinone
8 Curcumin
7 Baicalein
6 Resveratrol
5 Fisetin
5 Quercetin
4 Boron
4 Citric Acid
4 EGCG (Epigallocatechin Gallate)
3 Honokiol
3 Pterostilbene
3 Shikonin
2 5-fluorouracil
2 Alpha-Lipoic-Acid
2 Berberine
2 Ellagic acid
2 Gambogic Acid
2 Ginkgetin
2 Magnolol
2 Nimbolide
2 doxorubicin
1 Coenzyme Q10
1 Silver-NanoParticles
1 Atorvastatin
1 Boswellia (frankincense)
1 Carnosic acid
1 Capsaicin
1 Chrysin
1 Crocetin
1 Ursolic acid
1 Deguelin
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 diet Methionine-Restricted Diet
1 Ferulic acid
1 Formononetin
1 Gallic acid
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Hydrogen Gas
1 Luteolin
1 Melatonin
1 Magnetic Fields
1 Neem
1 Propolis -bee glue
1 Piperine
1 Piperlongumine
1 Parthenolide
1 Gold NanoParticles
1 Rosmarinic acid
1 Silymarin (Milk Thistle) silibinin
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:267  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page