Bcl-2 Cancer Research Results

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
Source: HalifaxProj (inhibit) CGL-Driver Genes
Type: Antiapoptotic Oncogene
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
Scientific Papers found: Click to Expand⟱
5362- AV,    Anti-cancer effects of aloe-emodin: a systematic review
- Review, Var, NA
AntiCan↑, eff↝, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumCD↑, MMP↓, ROS↑, Apoptosis↑, CDK1↓, CycB/CCNB1↓, Bcl-2↓, PCNA↓, ATP↓, ER Stress↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, MMP2↓, Ca+2↑, DNAdam↑, Akt↓, PKCδ↓, mTORC2↓, GSH↓, ChemoSen↑,
5363- AV,    Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments
- Study, HCC, NA
AKT1↓, EGFR↓, PI3K↓, Bcl-2↓, TumCG↓, Apoptosis↑,
5369- AV,    Assessment of Anticancer Effects of Aloe vera on 3D Liver Tumor Spheroids in a Microfluidic Platform
- in-vitro, Liver, HepG2
tumCV↓, AntiCan↑, P53↑, Bcl-2↓,
5568- B-Gluc,  immuno,    Beta-glucans in oncology: revolutionizing treatment with immune power & tumor targeting
- Review, Var, NA
TNF-α↓, IL6↓, NF-kB↓, PD-L1↓, Imm↑, BAX↑, Bcl-2↓, TumCCA↑, angioG↓, VEGF↓, MMPs↓, OS↑, chemoP↑, eff↑, BioAv↑,
874- B-Gluc,    Potential promising anticancer applications of β-glucans: a review
- Review, NA, NA
AntiCan↑, TumCG↓, BAX↑, Bcl-2↓, IFN-γ↑, PI3K/Akt↑, MAPK↑, NFAT↑, NF-kB↑, ROS↑, NK cell↑, TumCCA↑, ERK↓, Telomerase↓,
2478- Ba,    The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway
- in-vitro, BC, MDA-MB-231
Bcl-2↓, BAX↓, Cyt‑c↑, Casp3↑, Ca+2↓,
2477- Ba,    Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells
- in-vitro, CRC, T24/HTB-9
TumCG↓, TumCCA↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, p‑Akt↓, Bcl-2↓, BAX↑, Bax:Bcl2↑, 12LOX↓,
2600- Ba,    Baicalein Induces Apoptosis and Autophagy via Endoplasmic Reticulum Stress in Hepatocellular Carcinoma Cells
- in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, Bel-7402
ER Stress↑, Bcl-2↓, Ca+2↑, JNK↑, CHOP/DDIT3↑, Casp9↑, Casp3↑, PARP↑, Apoptosis↑, UPR↑,
2597- Ba,    Baicalein – An Intriguing Therapeutic Phytochemical in Pancreatic Cancer
- Review, PC, NA
chemoP↑, ChemoSen↑, 12LOX?, Bcl-2↓, BAX↑, Mcl-1↓, ERK↓, Prx6↑, Dose↝, BioAv↓, eff↑,
2629- Ba,    Baicalein, a Component of Scutellaria baicalensis, Attenuates Kidney Injury Induced by Myocardial Ischemia and Reperfusion
- in-vivo, Nor, NA
*RenoP↑, *Apoptosis↓, *TNF-α↓, *IL1↓, *Bcl-2↑, *BAX↓, *Akt↑,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2/KDR/Flk1↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP/DDIT3↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
5498- Ba,    Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis
- in-vitro, Lung, H460
12LOX↓, Dose↝, TumCCA↑, CDK1↓, CycB/CCNB1↓, Apoptosis↑, Bcl-2↓, P53↑, BAX↑, TumCP↓,
5248- Ba,  BA,  doxoR,    Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, HUVECs
toxicity↝, ChemoSen↑, selectivity↑, Apoptosis↑, necrosis↑, MMP↓, DNAdam↑, cl‑PARP↑, MRP1/ABCC1↓, Bcl-2↓, hepatoP↑, cardioP↑, BioAv↝,
1288- Ba,    The Traditional Chinese Medicine Baicalein Potently Inhibits Gastric Cancer Cells
- in-vitro, GC, SGC-7901
TumCG↓, TumCCA↑, Apoptosis↑, MMP↓, Bcl-2↓, BAX↑,
1533- Ba,    Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation
- in-vitro, BrCC, MCF7 - in-vitro, Nor, MCF10
tumCV↓, i-ROS↑, MMP↓, Bcl-2↓, BAX↑, Cyt‑c↑, Casp9↑, Casp3↑, eff↓, selectivity↑, *toxicity∅, Apoptosis↑, Fenton↑,
1532- Ba,    Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives
- Review, NA, NA
ROS↑, ER Stress↑, Ca+2↑, MMPs↓, Cyt‑c↑, Casp3↑, ROS↑, DR5↑, ROS↑, BAX↑, Bcl-2↓, MMP↓, Casp3↑, Casp9↑, P53↑, p16↑, P21↑, p27↑, HDAC10↑, MDM2↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IκB↓, IκB↑, BAX↑, Bcl-2↓, ROS⇅, BNIP3↑, p38↑, 12LOX↓, Mcl-1↓, Wnt?, GLI2↓, AR↓, eff↑,
1523- Ba,    Baicalein induces human osteosarcoma cell line MG-63 apoptosis via ROS-induced BNIP3 expression
- in-vitro, OS, MG63 - in-vitro, Nor, hFOB1.19
TumCD↑, Apoptosis↑, ROS↑, eff↓, Casp3↑, Bcl-2↓, selectivity↑, Cyt‑c↑, LDH?, BNIP3?, BAX↑,
1521- Ba,    Baicalein induces apoptosis via ROS-dependent activation of caspases in human bladder cancer 5637 cells
- in-vitro, Bladder, 5637
TumCG↓, Apoptosis↑, IAP1↓, IAP2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, MMP↓, Casp8↑, BID↑, ROS?, eff↓, DR4↑, DR5↑, FasL↑, TRAIL↑,
5539- BBM,    Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway
- vitro+vivo, CRC, SW480
tumCV↓, TumCCA↑, MMP↓, P53↑, Casp3↑, Casp9↑, BAX↑, PARP↑, Bcl-2↓, TumVol↑,
5543- BBM,    Enhanced anti-metastatic and anti-tumorigenic efficacy of Berbamine loaded lipid nanoparticles in vivo
- in-vivo, Lung, B16-F10 - vitro+vivo, Lung, A549 - in-vitro, BC, MDA-MB-231
BioAv↓, Half-Life↓, eff↑, TumMeta↓, TumCP↓, TumCG↓, Apoptosis↑, TumCCA↑, MMP2↓, MMP9↓, VEGF↓, Bcl-2↓, eff↑, EPR↑,
5553- BBM,    A review on berbamine–a potential anticancer drug
- Review, Var, NA
P-gp↓, MDR1↓, survivin↓, NF-kB↓, TumCP↓, TumCCA↑, Apoptosis↑, SMAD3↑, P21↑, cycD1/CCND1↓, cMyc↑, Bcl-2↓, Bcl-xL↓, BAX↑, CaMKII ↓, ChemoSen↑, MMP2↓, MMP9↓, TIMP1↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, cl‑PARP↑, IL6↓, ROS↑,
5548- BBR,    Berbamine induces SMMC-7721 cell apoptosis via upregulating p53, downregulating survivin expression and activating mitochondria signaling pathway
- in-vitro, HCC, SMMC-7721 cell
TumCG↓, Apoptosis↑, Cyt‑c↑, BAX↑, P53↑, Bcl-2↓, survivin↓,
1398- BBR,    Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage
- in-vitro, Kidney, NA
TumCP↓, TumCMig↓, ROS↑, Apoptosis↑, BAX↑, BAD↑, Bak↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, E-cadherin↑, TIMP1↑, γH2AX↑, Bcl-2↓, N-cadherin↓, Vim↓, Snail↓, RAD51↓, PCNA↓,
1394- BBR,  DL,    Synergistic Inhibitory Effect of Berberine and d-Limonene on Human Gastric Carcinoma Cell Line MGC803
- in-vitro, GC, MGC803
eff↑, ROS↑, MMP↓, Casp3↑, Bcl-2↓, TumCCA↑,
1393- BBR,  EPI,    Berberine promotes antiproliferative effects of epirubicin in T24 bladder cancer cells by enhancing apoptosis and cell cycle arrest
- in-vitro, Bladder, T24/HTB-9
ChemoSen↑, TumCCA↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, P53↑, P21↑, Bcl-2↓, ROS↑,
1390- BBR,  Rad,    Berberine Inhibited Radioresistant Effects and Enhanced Anti-Tumor Effects in the Irradiated-Human Prostate Cancer Cells
- in-vitro, Pca, PC3
RadioS↑, Apoptosis↑, ROS↑, eff↑, BAX↑, Casp3↑, P53↑, p38↑, JNK↑, Bcl-2↓, ERK↓, HO-1↓,
1386- BBR,    Berberine-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, ROS↑, JNK↑, MMP↓, Bcl-2↓, BAX↑, Cyt‑c↑, AIF↝,
1400- BBR,    Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells
- in-vitro, Melanoma, U266
ROS↑, TumCCA↑, Apoptosis↑, miR-21↓, Bcl-2↓, NF-kB↓, Set9↑,
2335- BBR,    Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer
- in-vitro, CRC, HT29 - in-vitro, CRC, HCT116 - in-vivo, NA, NA
PKM2↓, Glycolysis↓, p‑STAT3↓, Bcl-2↓, cycD1/CCND1↓, TumCG↓, Ki-67↓, lactateProd↓, glucose↓,
2670- BBR,    Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases
- Review, Var, NA
*Inflam↓, *antiOx↑, *Ca+2↓, *BioAv↓, *BioAv↑, *BioAv↑, *angioG↑, *MAPK↓, *AMPK↓, *NF-kB↓, VEGF↓, PI3K↓, Akt↓, MMP2↓, Bcl-2↓, ERK↓,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE↓, *memory↑, *BioAv↓,
5634- BCA,    Molecular Mechanisms of Biochanin A in AML Cells: Apoptosis Induction and Pathway-Specific Regulation in U937 and THP-1
- in-vitro, AML, U937 - in-vitro, AML, THP1
Apoptosis↑, Casp7↑, PARP1↑, Bcl-2↓, Myc↓, CHOP/DDIT3↑, P21↑, p62↑, TumCCA↑, TXNIP↑, ROS↑, *antiOx↑, *Inflam↓, *neuroP↑, AntiCan↑, TumCP↓, angioG↓, TumMeta↓, VEGF↓, MMPs↓, tumCV↓, DNAdam↑, CHOP/DDIT3↑, cMyc↓, BioAv↓, Half-Life↓, BioAv↑,
5636- BCA,    Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells
- vitro+vivo, Lung, A549
tumCV↓, TumCCA↑, Apoptosis↑, MMP↓, TumCG↓, P21↑, Casp3↑, Bcl-2↑,
5639- BCA,    Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition
- in-vitro, BC, NA
TumCP↓, ROS↑, Apoptosis↑, Bcl-2↓, p‑PI3K↓, p‑Akt↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, CycD3↓, CycB/CCNB1↓, CDK1↓, CDK2↓, CDK4↓, P21↑, p27↑, P53↑, tumCV↓, PI3K↓, Akt↓,
6513- BCP,    β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products
Apoptosis↑, TumCG↓, TumMeta↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, IAP1↓, IAP2↓, Bcl-2↓, Bcl-xL↓, survivin↓, COX2↓, cycD1/CCND1↓, cMyc↓, TumCI↓, MMP9↓, ICAM-1↓, angioG↓, VEGF↓, NF-kB↓,
6512- BCP,    Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells
- in-vitro, MM, NA
CB2 / CNR2↑, BAX↑, Bcl-2↓, Casp3↑, TumCP↓, Apoptosis↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Inflam↓, chemoPv↑, neuroP↑, *BioAv↝, CB2 / CNR2↑, tumCV↓,
6497- BCP,  Cisplatin,    Beta-Caryophyllene Enhances the Anti-Tumor Activity of Cisplatin in Lung Cancer Cell Lines through Regulating Cell Cycle and Apoptosis Signaling Molecules
- in-vitro, Lung, NA
TumCG↓, TumCP↓, Apoptosis↑, toxicity↓, ChemoSen↑, P21↑, Bcl-xL↑, Bcl-2↓, EMT↓, E-cadherin↑, eff↑, MMP↓,
6499- BCP,    JAK1/STAT3 regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation
- in-vitro, OS, MG63
ROS↑, Apoptosis↑, TumCP↓, BAX↑, Casp3↑, Bcl-2↓, MMP↓, DNAdam↑, TNF-α↓, COX2↓, NF-kB↓, IL6↓, Inflam↓, JAK1↑, STAT3↑,
6501- BCP,    β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study
- in-vitro, Oral, KB
TumCG↓, Apoptosis↑, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, ROS↑, MMP↓, DNAdam↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, PCNA↓, cycD1/CCND1↓, TNF-α↓, COX2↓, iNOS↓, IL6↓, VEGF↓,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
6509- BCP,    β­caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCP↓, Ki-67↓, PCNA↓, P21↓, P53↑, DNAdam↑, TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑, BAX↑, Bcl-2↓, GSH↑, GPx↑, 4-HNE↑, ROS↓, antiOx↑, lipid-P↓,
5591- BetA,    Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment
- Review, BC, NA
BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP/DDIT3↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,
5583- BetA,    Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells
- vitro+vivo, NA, NA
ROS↑, Bcl-2↓, BAX↑, TOP1↝, eff↝, toxicity↓, toxicity↓, selectivity↑,
1305- BetA,    Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells
- in-vitro, UEC, NA
Apoptosis↑, Bcl-2↓, BAX↑,
1285- BetA,    Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells
- in-vitro, Var, NA
Apoptosis↑, Bcl-2↓, cycD1/CCND1↓, BAX↑,
2721- BetA,    Proteomic Investigation into Betulinic Acid-Induced Apoptosis of Human Cervical Cancer HeLa Cells
- in-vitro, Cerv, HeLa
ROS↑, Dose↝, Bcl-2↓, BAX↑, ER Stress↑,

Showing Research Papers: 101 to 150 of 634
Prev Page 3 of 13 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 634

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↑, 1,   Copper↑, 1,   Fenton↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 2,   GSH↑, 1,   HO-1↓, 2,   lipid-P↓, 1,   NRF2↓, 1,   p‑NRF2↓, 1,   Prx6↑, 1,   ROS?, 1,   ROS↓, 1,   ROS↑, 28,   ROS⇅, 1,   i-ROS↑, 2,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   AIF↝, 1,   ATP↓, 2,   CDC25↓, 2,   MEK↓, 1,   MMP↓, 19,   Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   12LOX↓, 3,   AKT1↓, 1,   AMPK↑, 2,   cMyc↓, 4,   cMyc↑, 1,   glucose↓, 1,   Glycolysis↓, 3,   HK2↓, 1,   lactateProd↓, 1,   LDH?, 1,   LDHA↓, 1,   PDK1↓, 1,   PI3K/Akt↑, 1,   PKM2↓, 1,   PPARγ↓, 1,   p‑S6K↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 9,   p‑Akt↓, 5,   Apoptosis↑, 31,   ASK1↑, 1,   BAD↑, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 33,   Bax:Bcl2↑, 2,   Bcl-2↓, 48,   Bcl-2↑, 2,   Bcl-xL↓, 4,   Bcl-xL↑, 1,   BID↑, 1,   Casp↑, 1,   Casp1↑, 1,   Casp3↓, 1,   Casp3↑, 22,   cl‑Casp3↑, 4,   Casp7↑, 2,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 14,   cl‑Casp9↑, 4,   Cyt‑c↑, 13,   DR4↑, 1,   DR5↑, 3,   Fas↑, 1,   FasL↑, 2,   IAP1↓, 3,   IAP2↓, 2,   iNOS↓, 1,   JNK↑, 3,   MAPK↓, 2,   MAPK↑, 2,   Mcl-1↓, 2,   MDM2↓, 2,   MOMP↓, 1,   Myc↓, 1,   necrosis↑, 1,   p27↑, 4,   p38↑, 2,   p‑p38↓, 1,   Set9↑, 1,   survivin↓, 5,   Telomerase↓, 2,   TRAIL↑, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1,   other↓, 1,   tumCV↓, 9,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   ER Stress↑, 5,   GRP78/BiP?, 1,   IRE1↑, 1,   PERK↑, 2,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3?, 1,   BNIP3↑, 2,   LC3A↑, 1,   LC3II↑, 1,   p62↓, 1,   p62↑, 1,   SESN2↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↑, 8,   DNArepair↓, 1,   p16↑, 1,   P53↑, 11,   PARP↑, 2,   cl‑PARP↑, 5,   PARP1↑, 1,   PCNA↓, 4,   RAD51↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK2↓, 2,   CDK4↓, 3,   Cyc↓, 1,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 7,   CycD3↓, 1,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   P21↓, 1,   P21↑, 9,   RB1↑, 1,   TumCCA↑, 23,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CSCs↓, 1,   Diff↓, 1,   EMT↓, 2,   EMT↑, 1,   ERK↓, 6,   p‑ERK↓, 1,   Gli1↓, 1,   GSK‐3β↓, 1,   HDAC10↑, 1,   mTOR↓, 3,   p‑mTOR↓, 3,   p‑mTORC1↓, 1,   mTORC2↓, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH↓, 2,   OCT4↓, 1,   PI3K↓, 8,   p‑PI3K↓, 1,   PTEN↑, 3,   RAS↓, 1,   Shh↓, 1,   Smo↓, 1,   SOX2↓, 2,   STAT3↓, 5,   STAT3↑, 1,   p‑STAT3↓, 1,   TOP1↝, 1,   TOP2↓, 1,   TumCG↓, 12,   Wnt?, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   Ca+2↑, 5,   CAFs/TAFs↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 5,   FAK↓, 2,   GLI2↓, 1,   Ki-67↓, 2,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 11,   MMP3↓, 1,   MMP9↓, 9,   MMPs↓, 4,   N-cadherin↓, 3,   NFAT↑, 1,   PKCδ↓, 1,   Rho↓, 1,   ROCK1↓, 2,   SMAD3↑, 1,   Snail↓, 3,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP1↑, 2,   TIMP2↓, 1,   TIMP2↑, 1,   TumCI↓, 6,   TumCMig↓, 3,   TumCP↓, 12,   TumCP↑, 1,   TumMeta↓, 7,   Twist↓, 1,   TXNIP↑, 1,   uPA↓, 3,   Vim↓, 5,   ZO-1↑, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   EGFR↓, 3,   EPR↑, 2,   Hif1a↓, 4,   VEGF↓, 12,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

P-gp↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 3,   CCR7↓, 1,   CD4+↓, 1,   COX2↓, 6,   CXCR4↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL1β↓, 1,   IL6↓, 8,   Imm↑, 1,   Inflam↓, 5,   IκB↑, 1,   p‑IκB↓, 1,   JAK1↑, 1,   JAK2↓, 1,   MCP1/CCL2↓, 2,   NF-kB↓, 12,   NF-kB↑, 1,   NK cell↑, 1,   PD-L1↓, 2,   PGE2↓, 3,   TNF-α↓, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 3,   BioAv↝, 1,   ChemoSen↑, 12,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 4,   eff↓, 3,   eff↑, 15,   eff↝, 3,   Half-Life↓, 2,   MDR1↓, 1,   MRP1/ABCC1↓, 2,   RadioS↑, 4,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 3,   IL6↓, 8,   Ki-67↓, 2,   LDH?, 1,   Myc↓, 1,   PD-L1↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 5,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 3,   chemoPv↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 1,   Pain↓, 1,   RenoP↑, 1,   toxicity↓, 3,   toxicity↝, 1,   TumVol↑, 1,  
Total Targets: 274

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 1,   Ferroptosis↓, 1,   GPx↑, 2,   lipid-P↓, 2,   NRF2↑, 3,   ROS↓, 3,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↓, 1,   p‑AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Apoptosis↓, 2,   BAX↓, 2,   Bcl-2↑, 1,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   MAPK↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IL1↓, 1,   Inflam↓, 4,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 1,   BioEnh↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 5,   Obesity↓, 1,   RenoP↑, 2,   toxicity↓, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 50

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
36 Curcumin
29 Silver-NanoParticles
28 Thymoquinone
24 Quercetin
16 Apigenin (mainly Parsley)
15 Baicalein
15 EGCG (Epigallocatechin Gallate)
13 Allicin (mainly Garlic)
13 Betulinic acid
12 Fisetin
12 Shikonin
11 Sulforaphane (mainly Broccoli)
11 Berberine
11 Emodin
11 Silymarin (Milk Thistle) silibinin
10 Resveratrol
10 Gambogic Acid
10 Garcinol
9 Cisplatin
9 Eugenol
9 Honokiol
9 Luteolin
8 Capsaicin
8 Lycopene
7 Magnetic Fields
7 Ashwagandha(Withaferin A)
7 D-limonene
7 Radiotherapy/Radiation
7 Beta-Caryophyllene
7 Carvacrol
7 Graviola
7 Nimbolide
7 Piperlongumine
6 Boron
6 Cinnamon
6 Ursolic acid
6 Dandelion Root
6 Formononetin
6 Ginkgetin
6 Magnolol
5 5-fluorouracil
5 Astragalus
5 Artemisinin
5 Paclitaxel/Taxol
5 Astaxanthin
5 Boswellia (frankincense)
5 Carnosic acid
5 Phenethyl isothiocyanate
5 Rosmarinic acid
5 Urolithin
4 Photodynamic Therapy
4 Alpha-Lipoic-Acid
4 Metformin
4 Melatonin
4 Aloe anthraquinones
4 Biochanin A
4 Bufalin/Huachansu
4 α-Bisabolol / Chamomile oil
4 Crocetin
4 Ellagic acid
4 Eurycomanone
4 Ferulic acid
4 Geraniol
4 Ginkgolide B
4 Juglone
4 Propolis -bee glue
3 3-bromopyruvate
3 Gemcitabine (Gemzar)
3 immunotherapy
3 doxorubicin
3 Berbamine
3 Chemotherapy
3 Caffeic acid
3 Chlorogenic acid
3 chaetocin
3 chitosan
3 Chlorophyllin
3 Chrysin
3 Evodiamine
3 Gallic acid
3 Ginkgolic acids
3 Ginger/6-Shogaol/Gingerol
3 Laetrile B17 Amygdalin
3 Oleuropein
3 Phenylbutyrate
3 Selenite (Sodium)
3 VitK3,menadione
2 tamoxifen
2 Ajoene (compound of Garlic)
2 DTS(dibenzyl trisulphide) from Anamu
2 Andrographis
2 beta-glucans
2 Baicalin
2 Brucea javanica
2 brusatol
2 Bromelain
2 borneol
2 Genistein (soy isoflavone)
2 Butyrate
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Citric Acid
2 Carvone
2 Cucurbitacin
2 Docetaxel
2 Electrical Pulses
2 HydroxyTyrosol
2 Propyl gallate
2 salinomycin
2 Selenium
2 Taurine
2 Vitamin K2
1 Coenzyme Q10
1 Acoschimperoside P, 2’-acetate
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 alpha Linolenic acid
1 Anethole/trans-Anethole
1 Angelica archangelica / Garden Angelica
1 Aspirin
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 epirubicin
1 selenomethionine
1 Zinc
1 Celastrol
1 Prebiotic
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Hydroxycinnamic-acid
1 Copper and Cu NanoParticles
1 Oxaliplatin
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Dichloroacetate
1 Deguelin
1 Date Fruit Extract
1 Fenbendazole
1 Isoliquiritigenin
1 carboplatin
1 olaparib/LYNPARZA
1 Galloflavin
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Hydrogen Gas
1 HydroxyCitric Acid
1 Hyperthermia
1 Huperzine A/Huperzia serrata
1 Licorice
1 Methylene blue
1 Magnetic Field Rotating
1 Methylglyoxal
1 Mushroom Shiitake, AHCC
1 Naringin
1 Neem
1 Oleocanthal
1 Orlistat
1 sericin
1 Physalin F & B
1 Piperine
1 Plumbagin
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 isoflavones
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 Selenium NanoParticles
1 Auranofin
1 Salvia miltiorrhiza
1 Spermidine
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Tomatine
1 Vitamin D3
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:27  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page