Bcl-xL Cancer Research Results

Bcl-xL, Bcl-xL: Click to Expand ⟱
Source:
Type: pro-survival proteins
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL.
BCL-XL overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-XL plays essential roles in the maintenance of cancer stem cell phenotype.
Scientific Papers found: Click to Expand⟱
7588- I3C,    Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells
- in-vitro, AML, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, BAX↑, PUMA↑, NOXA↑, APAF1↑, NF-kB↓, IAP1↓, Bcl-xL↓, Bcl-2↓, XIAP↓, Myc↓, ChemoSen↑, Casp9↑, cl‑PARP↑, eff↑,
7772- IBC,    Isobavachalcone inhibits acute myeloid leukemia: Potential role for ROS-dependent mitochondrial apoptosis and differentiation
- vitro+vivo, AML, NA
Apoptosis↑, Diff↑, tumCV↓, TumCP↓, MMP↓, BAX↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, p‑MEK↑, p‑ERK↑, ROS↑, eff↓,
9191- ITCs,  AITC,  BITC,  PEITC,  SFN  Molecular Targets of Isothiocyanates in Cancer: Recent Advances
- Review, Var, NA
Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,
1923- JG,    Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells
- in-vitro, Endo, NA
TumCP↓, TumCCA↑, cycA1/CCNA1↓, ROS↑, P21↑, CDK2↓, CDK1↓, CDC25↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Cyt‑c↑,
8060- KAE,    Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells
- in-vitro, CRC, HT-29
TumCCA↑, DNAdam↑, ChrCon↑, cl‑Casp9↑, cl‑Casp3↑, cl‑Casp7↑, cl‑PARP↑, MPT↑, Cyt‑c↑, Bcl-xL↓, Bak↑, Akt↓, BAD↑, Casp↑, MMP↓,
8151- lamb,    Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid
- in-vitro, BC, MCF7 - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCCA↑, cl‑PARP↑, p‑STAT3↓, NF-kB↓, XIAP?, survivin↓, Bcl-2↓, Bcl-xL↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ac‑p65↑, Obesity↓, miR-134↑,
8150- lamb,    Reactive oxygen species dependent phosphorylation of the liver kinase B1/AMP activated protein kinase/ acetyl-CoA carboxylase signaling is critically involved in apoptotic effect of lambertianic acid in hepatocellular carcinoma cells
- in-vitro, HCC, HepG2 - in-vitro, HCC, SK-HEP-1
lipidLev↓, TumCCA↑, cl‑Casp3↑, cl‑PARP↑, AMPK↑, Akt↓, mTOR↓, Bcl-2↓, Bcl-xL↓, COX2/PTGS2↓, ROS↑, eff↓, p‑STK11/LKB1↑, p‑ACC↑, *Obesity↓, *Stress↓, *antiAll↑, tumCV↓, selectivity↑, TumCP↓, *antiAll↑,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8248- LCA,    Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress
- in-vitro, NSCLC, A549 - in-vitro, Lung, H460
tumCV↓, TumCG↓, TumCCA↑, MDM2↓, CycB/CCNB1↓, cDC2↓, CDC25↓, Casp3↑, PARP↑, ER Stress↑, p‑eIF2α↑, ATF4↑, TumCP↓, selectivity↑, Bcl-xL↓, Bcl-2↓,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8276- LE,  Cisplatin,    Glycyrrhizin enhances the antitumor activity of cisplatin in non‑small cell lung cancer cells by influencing DNA damage and apoptosis
- in-vitro, NSCLC, NA
tumCV↓, ChemoSen↑, Apoptosis↑, TumCCA↑, Bcl-xL↑, cl‑Casp↑, γH2AX↑, P53↑,
8196- LGE,    Lemongrass essential oil and citral inhibit Src/Stat3 activity and suppress the proliferation/survival of small-cell lung cancer cells, alone or in combination with chemotherapeutic agents
- in-vitro, Lung, NA
Bcl-xL↓, Mcl-1↓, TumCP↓, STAT3↑, TumCP?,
8183- LGE,    Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
TumCG↓, selectivity↑, MMP↓, ROS↑, GSH↓, eff↓, p‑P53↑, BAX↑, Bcl-2↓, Bcl-xL↓, cl‑Casp3↑,
8330- LIN,    SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death
- in-vitro, GBM, U87MG
tumCV↓, OCR↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, Casp3↑, Casp9↑, Apoptosis↑, SOD↓, SIRT3↓, mt-ROS↑,
8321- LIN,  doxoR,    Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells
- in-vitro, BC, MCF7
ChemoSen↑, EPR↑, Bcl-xL↓, P-gp/ABCB1↓, TumCCA⇅, tumCV↓, Apoptosis↑,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
2924- LT,    Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1
- in-vitro, GC, NA - in-vivo, NA, NA
p‑STAT3↓, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, HSP90↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
4519- MAG,    Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiAg↑, *BBB↑, *BioAv↓, BAD↑, Casp3↑, Casp6↑, Casp9↑, JNK↑, Bcl-xL↓, PTEN↑, Akt↓, NF-kB↓, MMP7↓, MMP9↓, uPA↓, Hif1a↓, VEGF↓, FOXO3↓, Ca+2↑, TumCCA↑, ROS↑, Cyt‑c↑,
8628- MBZ,    Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H460
TumCP↓, TumCMig↓, Apoptosis↑, ROS↑, p‑JAK2↓, p‑STAT3↓, eff↓, TumCG?, Bcl-xL↓, EMT↓, Snail↓, Twist↓,
194- MF,    Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke
- Review, Stroke, NA
*BAD↓, *BAX↓, *Casp3↓, *Bcl-xL↑, *p‑Akt↑, *MMP9↓, *p‑ERK↑, *HIF-1↓, *ROS↓, *VEGF↑, *Ca+2↓, *SOD↑, *IL2↑, *p38↑, *HSP70/HSPA5↑, *Apoptosis↓, *ROS↓, *NO↓,
9154- MG, MIC-1,    Moringin, an isothiocyanate modulates multiple cellular signalling molecules in breast cancer cells
- in-vitro, BC, NA
Ingr↝, *TumCG↓, Cyt‑c↑, P53↑, cl‑Casp7↑, survivin↓, Bcl-2↓, Bcl-xL↓, MMP↓, ROS↑, PHB↑,
9074- MGF,    Mangiferin prevents the growth of gastric carcinoma by blocking the PI3K-Akt signalling pathway
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
TumCP↓, Dose?, Bcl-2↓, Bcl-xL↓, Mcl-1↓, BAX↑, BAD?, cl‑Casp3↑, cl‑Casp9↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, toxicity↓,
9073- MGF,    Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase
- in-vitro, MM, NA
TumVol↓, Apoptosis↑, Casp3↑, MMP↓, NF-kB↓, IκB↑, XIAP↓, survivin↓, Bcl-xL↓,
9079- MGF,    Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model
- in-vivo, Melanoma, NA
TumMeta↓, TumCG↓, NF-kB↓, IKKα↓, MMPs↓, Casp3↑, PARP1↑, PUMA↑, P53↑, survivin↓, Bcl-xL↓, NIK↓,
8661- MLT,    Melatonin effect on breast and ovarian cancers by targeting the PI3K/Akt/mTOR pathway
- in-vitro, BC, NA - in-vitro, Ovarian, NA
PTEN↓, PI3K↓, Akt↓, mTOR↓, mTORC1↓, MDM2↓, BAD↑, Bcl-xL↑, P53↓, TumAuto↑, ULK1/ATG1↑, p‑Beclin-1/ATG6↑,
8897- MOR,    Morin promotes prostate cancer cells chemosensitivity to paclitaxel through miR-155/GATA3 axis
- vitro+vivo, Pca, DU145 - in-vitro, Pca, PC3
tumCV↓, GATA3↑, ChemoSen↑, Dose↝, miR-155↓, MMP?, Casp3↑, Casp9↑, P21↑, BAD↑, Bcl-xL↓, STAT3↓,
8898- MOR,    Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells
- in-vitro, Cerv, HeLa
TumCP↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, WEE1↑, CDK1↓, CDC25↓, survivin↓, CycB/CCNB1↓, Chk2↓, BAX↑, BAD↑, Cyt‑c↑, APAF1↑, Casp9↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, FasL↑, FADD↑, Casp10↑, PARP↑, PI3K↑, Akt↑, mTOR↑, p70S6↑, Diablo↑, Bcl-2↓, Bcl-xL↓, AMPK↓, IAP1↓, NF-kB↓, ROS↑,
8874- MOR,    The anticarcinogenic and anticancer effects of the dietary flavonoid, morin: Current status, challenges, and future perspectives
- Review, Var, NA
AntiCan↑, selectivity↑, *ROS↓, *Inflam↓, *p‑Akt↓, *NF-kB↓, ChemoSen↑, chemoPv↑, *toxicity↓, BioAv↑, BioAv↓, MRP1/ABCC1↝, BioAv↑, PCNA↓, hepatoP↑, NF-kB↓, TNF-α↓, IL6↓, PGE2↓, MMP2↓, MMP9↓, Apoptosis↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, FasL↑, FADD↑, ROS↑, MMP↓, BAX↑, Bcl-xL↓, Casp9↑, Casp3↑, EMT↓, Akt↓, Hippo↑,
8886- MOR,  doxoR,    Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1/AMPK/mTORC1 signaling pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
DNAdam↑, DNArepair↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CycB/CCNB1↓, PARP↓, Bcl-xL↓, p‑AMPK↑, p‑STK11/LKB1↑, p‑mTOR↓, p‑Akt↓, p‑GSK‐3β↓, tumCV↓,
8860- MOR,    Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis
- in-vitro, Cerv, HeLa - in-vitro, Nor, H4 - in-vitro, Lung, A549
NF-kB↓, IκB↓, survivin↓, Bcl-xL↓, cycD1/CCND1↓, COX2/PTGS2↓, MMP9↓, Akt↓, ChemoSen↑, Synergy↑,
8859- MOR,    Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
- in-vitro, Melanoma, U266 - in-vitro, BC, MCF7 - in-vitro, SCC, SCC4 - in-vitro, BC, MCF-10AT
STAT3↓, Src↓, JAK1↓, JAK2↓, PIAS-3↑, ChemoSen↑, SHP1↑, XIAP↓, cFLIP↓, Mcl-1↓, survivin↓, Bcl-2↓, Bcl-xL↓, IAP2/BIRC3↓, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, selectivity↑,
8774- MSM,    Methylsulfonylmethane Induces G1 Arrest and Mitochondrial Apoptosis in YD-38 Gingival Cancer Cells
- in-vitro, Oral, YD-38
P21↑, p27/CDKN1B↑, cycD1/CCND1↓, CDK4↓, Apoptosis↑, BAX↑, Bcl-2↓, Bcl-xL↓, Cyt‑c↑, TumCCA↑,
8968- mushLions,    Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells
- in-vitro, lymphoma, U937
Ingr?, Apoptosis↑, TumCP↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, XIAP↓, IAP1↓, Cyt‑c↑, MMP↓, cl‑PARP↑,
8951- mushLions,    Apoptotic mechanisms of gastric cancer cells induced by isolated erinacine S through epigenetic histone H3 methylation of FasL and TRAIL
- vitro+vivo, GC, NA
Apoptosis↑, ROS↑, selectivity↑, TumCG↓, FasL↑, TRAIL↑, PCNA↓, cycD1/CCND1↓, Casp3↑, Casp9↑, Casp8↑, Bcl-2↓, Bcl-xL↓, TumCCA↑, tumCV↓, TumVol↓, TumW↓,
8952- mushLions,    Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation
- vitro+vivo, CRC, DLD1
TNFR 1↑, Fas↑, FasL↑, Casp↑, Bcl-2↓, Bcl-xL↓, tumCV↓, selectivity↑, MMP2↓, MMP9↓, Apoptosis↑, Dose↝,
1269- NCL,    Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway
- in-vitro, Pca, DU145
STAT3↓, TumCG↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cMyc↓, Bcl-xL↓,
6775- Neem,  Nimb,    Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment
- Review, Nor, NA
*antiOx↑, P53↑, PTEN↑, NF-kB↓, PI3K↓, Akt↓, Bcl-2↓, VEGF↓, *Inflam↓, *COX2/PTGS2↓, *5LO↝, *Wound Healing↑, *Imm↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, *AntiViral↑, *Bacteria↑, *AntiBio↑, *AntiFungal↑, cMyc↓, BAX↓, IAP1↓, IAP2/BIRC3↓, Bcl-xL↓, survivin↓, XIAP↓, angioG↓,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
6493- Nimb,    Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment
- in-vivo, CRC, HCT116 - vitro+vivo, CRC, HT29
TumCP↓, Apoptosis↑, NF-kB↓, IKKα↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, cMyc↓, cycD1/CCND1↓, MMP9↓, CXCR4↓, ICAM-1↓, VEGF↓, angioG↓, TumCG↓,
2064- PB,  Rad,    Phenylbutyrate Attenuates the Expression of Bcl-XL, DNA-PK, Caveolin-1, and VEGF in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
Bcl-xL↓, Cav1↓, VEGF↓, RadioS↑, chemoP↑, HDAC↓, *toxicity↓, Diff↑, Prot↓,
2045- PB,    Phenylbutyrate—a pan-HDAC inhibitor—suppresses proliferation of glioblastoma LN-229 cell line
- in-vitro, GBM, LN229 - in-vitro, GBM, LN-18
HDAC↓, TumCG↓, TumCCA↑, P21↑, Bcl-2↓, Bcl-xL↓, BioAv↑,
4923- PEITC,    Quantitative chemical proteomics reveals that phenethyl isothiocyanate covalently targets BID to promote apoptosis
- Study, Var, NA
cl‑BID↑, Apoptosis↑, Bcl-xL↓, Casp8↑, Cyt‑c↑,
5185- PEITC,  SFN,    Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells
- in-vitro, Pca, PC3
NF-kB↓, p65↓, VEGF↓, cycD1/CCND1↓, Bcl-xL↓, IKKα↓,
5208- PI,    Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
- in-vitro, GC, SNU16 - in-vitro, Nor, GES-1
TumCP↓, Apoptosis↑, BAX↑, BAD↑, Cyt‑c↑, cl‑PARP↑, cl‑Casp3↑, Bcl-2↓, Bcl-xL↓, p‑PI3K↓, p‑Akt↓, Ki-67↓, toxicity↓, RadioS↑,
1947- PL,    Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer
- in-vitro, GC, SGC-7901 - in-vitro, GC, NA
TrxR1↓, ROS↑, ER Stress↑, mtDam↑, selectivity↑, NO↑, TumCCA↑, mt-ROS↑, Casp9↑, Bcl-2↓, Bcl-xL↓, cl‑PARP↑, eff↓, lipid-P↑,
5160- PLB,  VitK3,    Plumbagin, Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization
- in-vitro, Melanoma, U266
STAT3↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-xL↓, VEGF↓, Casp3↑, cl‑PARP↑, TumCCA↑, ChemoSen↑,
5161- PLB,    Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
- in-vitro, SCC, SCC25
TumCCA↑, Apoptosis↑, TumAuto↑, Bcl-2↓, Bcl-xL↓, BAX↑, PI3K↓, Akt↓, mTOR↓, GSK‐3β↓, MAPK↓, ROS↑, eff↓, CDC2↓, CycB/CCNB1↓, P21↑, p27/CDKN1B↑, P53↑, Casp9↑, Casp3↑,
78- QC,    Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells
- in-vitro, Pca, PC3
IGF-1↓, IGF-2↓, IGFBP3↑, Bcl-2↓, Bcl-xL↓, Casp3↑, Apoptosis↑, BAX↑, DNAdam↑,
54- QC,    Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways
- in-vitro, BC, MCF7
EMT↓, E-cadherin↑, Vim↓, MMP2↓, NOTCH1↓, PI3K/Akt↓, PI3k/Akt/mTOR↓, p‑Akt↓, EZH2↓, H3K27ac↓, TumCCA↑, CSCs↓, CDK1↓, CycB/CCNB1↓, Bcl-xL↓, Bcl-2↓, Nanog↓, H3↓,

Showing Research Papers: 101 to 150 of 180
Prev Page 3 of 4 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 180

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 2,   Catalase↑, 1,   Copper↑, 1,   frataxin↑, 1,   GPx↓, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 9,   GSH↑, 2,   GSR↑, 1,   H2O2↓, 1,   H2O2↑, 1,   i-H2O2↑, 1,   HO-1↓, 4,   HO-1↑, 1,   HO-2↓, 1,   lipid-P↓, 2,   lipid-P↑, 4,   MDA↑, 2,   NRF2↓, 4,   NRF2↑, 5,   NRF2↝, 1,   ROS?, 1,   ROS↓, 3,   ROS↑, 73,   ROS⇅, 2,   ROS↝, 1,   ROS∅, 1,   mt-ROS↑, 3,   SAM-e↝, 1,   SOD↓, 5,   SOD↑, 1,   TAC↓, 1,   Trx↑, 1,   ox-Trx1↑, 1,   TrxR↓, 1,   TrxR↑, 1,   TrxR1↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Bfl-1↓, 1,   CDC2↓, 2,   CDC25↓, 7,   compI↓, 1,   compIII↓, 1,   EGF↓, 1,   ETC↓, 2,   mtDam↑, 7,   OCR↓, 2,   PHB↑, 1,   PINK1↑, 1,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ACC↑, 1,   p‑ACC↑, 1,   ACLY↓, 1,   ALAT↓, 1,   AMPK↓, 2,   AMPK↑, 7,   p‑AMPK↑, 2,   ATP↓, 3,   ECAR↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FAO↑, 1,   FASN↓, 2,   FASN↑, 1,   FBPase↑, 1,   glucoNG↑, 1,   GlucoseCon↓, 3,   GlutMet↓, 1,   Glycolysis↓, 6,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   HK2↓, 4,   lactateProd↓, 3,   LDHA↓, 1,   LDL↓, 2,   lipidLev↓, 1,   NAD↝, 1,   NADPH↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   PFK1↓, 1,   PFK2↓, 1,   PKM2↓, 3,   PLA2↓, 1,   p‑S6↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   TCA↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 6,   Apoptosis↓, 4,   Apoptosis↑, 71,   Apoptosis↝, 1,   mt-Apoptosis↑, 1,   ASC↑, 1,   BAD?, 1,   BAD↓, 1,   BAD↑, 15,   Bak↑, 13,   BAX↓, 2,   BAX↑, 66,   BAX↝, 1,   BAX∅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 7,   Bcl-2↓, 117,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↓, 166,   Bcl-xL↑, 8,   Bcl-xL↝, 2,   Bcl-xL∅, 1,   BID↓, 1,   BID↑, 6,   cl‑BID↑, 2,   BIM↓, 1,   BIM↑, 7,   BNIP3↑, 1,   Casp↑, 19,   cl‑Casp↑, 2,   Casp1↓, 1,   Casp10↑, 1,   Casp2↑, 2,   Casp3↓, 1,   Casp3↑, 72,   Casp3↝, 1,   cl‑Casp3↑, 16,   proCasp3↑, 1,   pro‑Casp3↝, 1,   Casp6↑, 3,   Casp7↑, 4,   cl‑Casp7↑, 2,   Casp8↑, 17,   cl‑Casp8↑, 4,   proCasp8↑, 1,   Casp9↓, 1,   Casp9↑, 48,   cl‑Casp9↑, 9,   cFLIP↓, 3,   Cyt‑c↓, 1,   Cyt‑c↑, 42,   Cyt‑c↝, 1,   Diablo↑, 4,   DR5↑, 10,   FADD↑, 3,   Fas↑, 8,   FasL↑, 5,   IAP1↓, 19,   IAP2/BIRC3↓, 9,   IAP2/BIRC3↑, 1,   iNOS↓, 6,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 32,   cl‑Mcl-1↑, 1,   MDM2↓, 11,   MOMP↑, 1,   necrosis↑, 1,   NOXA↑, 6,   p38↓, 1,   p38↑, 4,   p‑p38↓, 1,   p‑p38↑, 3,   PUMA↑, 6,   survivin↓, 57,   survivin↝, 1,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↑, 5,   XIAP?, 1,   XIAP↓, 30,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 43,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 14,   BRAF↝, 1,   CaMKII ↓, 1,   p‑cMET↑, 1,   cSrc↓, 4,   EGFR↓, 7,   EGFR↝, 1,   ERK↓, 12,   ERK↑, 1,   p‑ERK↓, 7,   p‑ERK↑, 2,   HCAR2↑, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   Hippo↑, 1,   IGF-1R↓, 2,   IKKα↓, 6,   IKKα↑, 1,   p‑IKKα↓, 3,   IκB↓, 2,   IκB↑, 1,   JAK↓, 2,   JAK1↓, 4,   JAK2↓, 9,   p‑JAK2↓, 3,   JNK↓, 1,   JNK↑, 9,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAP2K1/MEK1↓, 1,   MAPK↓, 11,   MAPK↑, 1,   MAPK↝, 1,   p‑MAPK↑, 1,   MARK4↓, 1,   MEK↓, 2,   p‑MEK↓, 3,   p‑MEK↑, 1,   mTOR↓, 20,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 5,   NIK↓, 1,   p70S6↑, 1,   P70S6K↓, 2,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 28,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 2,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 1,   PIAS-3↑, 1,   PKA↓, 2,   PKCδ↓, 3,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 13,   PTEN↝, 2,   Raf↓, 3,   RAS↓, 2,   RTK-RAS↓, 1,   SHP1↓, 1,   SHP1↑, 4,   Sp1/3/4↓, 3,   Src↓, 2,   STAT↓, 2,   STAT3↓, 35,   STAT3↑, 2,   p‑STAT3↓, 10,   STAT5↓, 2,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 2,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2,   ATF4↑, 5,   cJun↓, 1,   cJun↑, 2,   p‑cJun↑, 1,   cMyc↓, 21,   cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 3,   EZH2↓, 2,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↓, 1,   FOXO3↓, 2,   FOXO3↑, 2,   GATA3↑, 1,   H3↓, 2,   ac‑H3↑, 1,   H3K27ac↓, 1,   ac‑H4∅, 1,   HATs↓, 1,   HATs↑, 1,   HDAC↓, 17,   HDAC1↓, 4,   HDAC10↓, 1,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC4↓, 1,   HES1↓, 1,   miR-134↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-200b↑, 1,   miR-205↑, 1,   miR-21↓, 2,   miR-210↓, 1,   miR-34a↑, 2,   miR-34b-5p↑, 1,   miR-384↑, 1,   Myc↓, 2,   OCT4↓, 1,   other↓, 3,   other↝, 1,   Prot↓, 1,   SOX2↓, 1,   SUV39H↓, 1,   TCF-4↓, 1,   tumCV↓, 22,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 4,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 10,   GRP78/BiP↑, 3,   HSF1↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   IRE1↑, 2,   PERK↑, 2,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 2,   ATG5↑, 3,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   p‑Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 1,   LC3I↓, 1,   LC3II↑, 4,   p62↓, 2,   p62↑, 1,   PARK2↑, 1,   RUBCN↓, 1,   TumAuto↑, 14,   ULK1/ATG1↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   DNAdam↓, 1,   DNAdam↑, 15,   DNArepair↓, 1,   hTERT/TERT↓, 3,   MGMT↓, 1,   p16↑, 1,   P53↓, 2,   P53↑, 49,   P53↝, 1,   p‑P53↓, 1,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 9,   cl‑PARP↑, 47,   PARP1↑, 1,   PCNA↓, 8,   SIRT6↑, 1,   Telomerase↓, 4,   TOP1↓, 4,   TOP2↓, 2,   TRF2↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 10,   CDK2↓, 8,   CDK4↓, 12,   CDK6↓, 5,   CDK8↓, 1,   Chk2↓, 1,   ChrCon↑, 1,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 15,   cycD1/CCND1↓, 57,   cycD1/CCND1↝, 1,   CycD3↓, 1,   cycE/CCNE↓, 4,   cycE1↓, 1,   GADD45A↑, 1,   Ki-67↓, 7,   P21↓, 4,   P21↑, 35,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 14,   pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↓, 2,   TumCCA↑, 72,   TumCCA⇅, 1,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   BMI1↓, 1,   CD24↓, 1,   cFos↓, 2,   CSCs↓, 5,   Diff↑, 2,   Gli1↓, 2,   HH↓, 2,   IGF-1↓, 4,   IGF-2↓, 1,   IGFBP3↑, 2,   Ki-67↓, 7,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 2,   NOTCH↓, 5,   NOTCH1↓, 1,   NOTCH1↑, 1,   NOTCH2↑, 1,   PTCH1↓, 1,   Shh↓, 2,   Smo↓, 1,   TumCG?, 1,   TumCG↓, 38,   TumCP?, 1,   TumCP↓, 49,   Wnt↓, 5,   Wnt/(β-catenin)↓, 3,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 4,   AP-1↝, 1,   AXL↓, 1,   Ca+2↑, 8,   Ca+2↝, 3,   CAFs/TAFs↓, 1,   cal2↑, 1,   Cav1↓, 1,   E-cadherin↑, 12,   EMT↓, 18,   EMT↑, 1,   FAK↓, 6,   p‑FAK↓, 1,   Fibronectin↓, 1,   GIT1↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   LRP1↓, 1,   MMP-10↓, 2,   MMP1↓, 2,   MMP13↓, 1,   MMP16↓, 1,   MMP2↓, 26,   MMP2↝, 1,   MMP3↓, 3,   MMP7↓, 3,   MMP9↓, 36,   MMPs↓, 14,   MTA1↓, 1,   MUC4↓, 3,   N-cadherin↓, 5,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 3,   Slug↓, 2,   SMAD3↓, 1,   SMAD3↑, 1,   Snail↓, 8,   TET1↑, 1,   TGF-β↓, 4,   TIMP1↓, 1,   TIMP1↑, 2,   TIMP2↓, 2,   TSC1↑, 1,   TumCI?, 1,   TumCI↓, 13,   TumCI↑, 1,   TumCMig↓, 11,   TumMeta↓, 17,   TumMeta↑, 2,   Twist↓, 9,   Tyro3↓, 1,   uPA↓, 8,   Vim↓, 12,   Zeb1↓, 6,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 29,   angioG↑, 1,   CD31/PECAM-1↓, 5,   Endoglin↑, 1,   HIF-1↓, 1,   Hif1a↓, 20,   Hif1a↑, 1,   NO↑, 2,   VEGF↓, 43,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   CTR1↑, 1,   EPR↑, 1,   GLUT1↓, 2,   MMP?, 1,   MMP↓, 40,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,   SLC12A5↝, 1,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   cDC2↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 30,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCR2↓, 1,   CXCR4↓, 7,   CXCR4↑, 1,   DR4↑, 3,   HCAR2↑, 1,   ICAM-1↓, 6,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 2,   IL1α↓, 1,   IL1β↓, 4,   IL2↓, 1,   IL2↑, 1,   IL6↓, 16,   IL6↑, 1,   IL6↝, 1,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 12,   MCP1/CCL2↓, 1,   MDSCs↓, 1,   NAF1↓, 1,   NF-kB↓, 65,   NF-kB↝, 1,   p‑NF-kB↓, 1,   NLRP3↓, 1,   NLRP3↑, 1,   p50↓, 1,   p65↓, 4,   p‑p65↓, 2,   ac‑p65↓, 1,   ac‑p65↑, 2,   PD-L1↓, 5,   PGE1↓, 1,   PGE2↓, 8,   PSA↓, 3,   PSA↝, 1,   TLR4↓, 3,   TNF-α↓, 14,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3,   TRAF1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 5,   AR↝, 1,   PPARα↓, 1,   PPARγ↓, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 9,   BioAv↑, 12,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 41,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 1,   CYP1A2↓, 1,   CYP3A4↓, 1,   Dose?, 3,   Dose↑, 1,   Dose↝, 12,   Dose∅, 1,   eff↓, 25,   eff↑, 22,   Half-Life↓, 2,   Half-Life↝, 2,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 6,   P450↓, 2,   RadioS↑, 10,   selectivity↑, 23,   selectivity↝, 1,   Synergy↑, 28,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 1,   ALP↓, 1,   AR↓, 5,   AR↝, 1,   ascitic↓, 1,   BRAF↝, 1,   BRCA1↑, 1,   EGFR↓, 7,   EGFR↝, 1,   EZH2↓, 2,   FOXM1↓, 2,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 3,   IL6↓, 16,   IL6↑, 1,   IL6↝, 1,   LDH↓, 1,   Maspin↑, 1,   Myc↓, 2,   PD-L1↓, 5,   PSA↓, 3,   PSA↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 8,   AntiTum↑, 6,   cardioP↑, 3,   chemoP↑, 8,   chemoPv↑, 4,   hepatoP↑, 8,   neuroP↑, 3,   Obesity↓, 1,   OS↑, 1,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 1,   toxicity↓, 6,   toxicity↝, 1,   TumVol↓, 14,   TumW↓, 7,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 1,  
Total Targets: 645

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 12,   Catalase↑, 8,   Fenton↓, 1,   GPx↑, 4,   GSH↑, 5,   GSR↑, 1,   GSTs↑, 3,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 2,   MPO↓, 1,   MPO↑, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 4,   RNS↓, 3,   ROS↓, 17,   ROS∅, 1,   SOD↓, 1,   SOD↑, 8,   SOD1↑, 1,   SOD2↑, 1,   TBARS↓, 1,   VitE↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↝, 1,   ALAT↓, 1,   AMPK↑, 1,   NAD↑, 1,   NADPH↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAD↓, 1,   BAX↓, 1,   BAX↑, 1,   Bcl-2↑, 1,   Bcl-xL↓, 1,   Bcl-xL↑, 2,   Casp3↓, 3,   Casp9↓, 1,   Cyt‑c↑, 1,   iNOS↓, 2,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑Akt↓, 1,   p‑Akt↑, 1,   p‑ERK↑, 1,   IGF-1R↓, 1,   JAK↓, 1,   JAK2↑, 1,   PDGFR-BB↓, 1,   PI3K↑, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 2,   other↝, 3,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP70/HSPA5↑, 1,   UPR↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↝, 1,   cal2↓, 1,   MMP2↓, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

HIF-1↓, 1,   NO↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT1↑, 1,   GLUT3↑, 1,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 4,   FOXP3↑, 1,   HMGB1↓, 2,   IL10↑, 1,   IL1β↓, 3,   IL2↑, 1,   IL4↑, 1,   IL6↓, 4,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 13,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 7,   NLRP3↓, 1,   PGE2↓, 2,   TNF-α↓, 3,   Treg lymp↝, 1,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 2,   BioAv↝, 2,   BioAv∅, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 2,   Dose∅, 1,   eff↑, 3,   GSTA1↑, 1,   Half-Life↝, 2,   Half-Life∅, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 2,   BP↓, 1,   BUN↓, 1,   CRP↓, 1,   IL6↓, 4,   LDH↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 5,   AntiArt↑, 2,   AntiCan↑, 4,   antiD↓, 1,   AntiDiabetic↑, 2,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 1,   chemoPv↑, 1,   hepatoP↓, 1,   hepatoP↑, 2,   memory↑, 2,   neuroP?, 1,   neuroP↑, 8,   Obesity↓, 2,   OS↑, 1,   radioP↑, 3,   RenoP↑, 1,   Stress↓, 1,   Stroke↓, 2,   toxicity↓, 5,   toxicity∅, 2,   Weight↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↓, 1,   AntiFungal↑, 1,   AntiViral↑, 2,   Bacteria↓, 3,   Bacteria↑, 1,   Sepsis↓, 1,  
Total Targets: 161

Scientific Paper Hit Count for: Bcl-xL, Bcl-xL
14 Thymoquinone
9 Apigenin (mainly Parsley)
6 Curcumin
6 Gossypol/AT-101
6 Morin
5 Baicalein
5 Quercetin
4 Alpha-Lipoic-Acid
4 EGCG (Epigallocatechin Gallate)
4 Sulforaphane (mainly Broccoli)
3 Cisplatin
3 Benzyl isothiocyanate
3 Boswellia (frankincense)
3 Fisetin
3 Gambogic Acid
3 Ginkgetin
3 Indole-3-carbinol
3 Phenethyl isothiocyanate
3 lambertianic acid
3 Luteolin
3 Mangiferin
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Nimbolide
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
2 Silver-NanoParticles
2 Paclitaxel/Taxol
2 Artemisinin
2 Berbamine
2 Beta-Caryophyllene
2 Boron
2 Butyrate
2 Carnosic acid
2 Capsaicin
2 chaetocin
2 Cucurbitacin
2 Docetaxel
2 Ursolic acid
2 Ellagic acid
2 Garcinol
2 Honokiol
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Linalool
2 doxorubicin
2 Phenylbutyrate
2 Plumbagin
2 VitK3,menadione
1 Astragalus
1 Camptothecin
1 Anethole/trans-Anethole
1 Berberine
1 Betulinic acid
1 brusatol
1 Black turtle bean
1 Carvacrol
1 Sorafenib (brand name Nexavar)
1 Cat’s Claw
1 Chrysin
1 Cinnamon
1 Citric Acid
1 Cranberry
1 Gemcitabine (Gemzar)
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 D-limonene
1 Emodin
1 Eurycomanone
1 Eugenol
1 Evodiamine
1 Formononetin
1 Isoliquiritigenin
1 Ginger/6-Shogaol/Gingerol
1 carboplatin
1 Chemotherapy
1 Hydrogen Gas
1 Hibiscus sabdariffa
1 Hyperthermia
1 Hyperoside
1 Isobavachalcone
1 Isothiocyanates
1 Allyl isothiocyanate
1 Juglone
1 Kaempferol
1 Licorice
1 Magnolol
1 mebendazole
1 Magnetic Fields
1 Moringin
1 Melatonin
1 Methylsulfonylmethane
1 Niclosamide (Niclocide)
1 Neem
1 Radiotherapy/Radiation
1 Piperine
1 Piperlongumine
1 Rosmarinic acid
1 Shikonin
1 Taurine
1 Photodynamic Therapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:28  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page