Bcl-xL Cancer Research Results

Bcl-xL, Bcl-xL: Click to Expand ⟱
Source:
Type: pro-survival proteins
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL.
BCL-XL overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-XL plays essential roles in the maintenance of cancer stem cell phenotype.
Scientific Papers found: Click to Expand⟱
78- QC,    Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells
- in-vitro, Pca, PC3
IGF-1↓, IGF-2↓, IGFBP3↑, Bcl-2↓, Bcl-xL↓, Casp3↑, Apoptosis↑, BAX↑, DNAdam↑,
54- QC,    Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways
- in-vitro, BC, MCF7
EMT↓, E-cadherin↑, Vim↓, MMP2↓, NOTCH1↓, PI3K/Akt↓, PI3k/Akt/mTOR↓, p‑Akt↓, EZH2↓, H3K27ac↓, TumCCA↑, CSCs↓, CDK1↓, CycB/CCNB1↓, Bcl-xL↓, Bcl-2↓, Nanog↓, H3↓,
84- QC,    Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression
- in-vitro, Pca, PC3
P21↑, cDC2↓, CDK1↓, CycB/CCNB1↓, Casp3↑, Bcl-2↓, Bcl-xL↓, BAX↑, pRB↓, TumCCA↑, Apoptosis↑,
83- QC,    Quercetin induces p53-independent apoptosis in human prostate cancer cells by modulating Bcl-2-related proteins: a possible mediation by IGFBP-3
- in-vitro, Pca, PC3
Bcl-2↓, Bcl-xL↓, BAX↑, IGFBP3↑,
79- QC,    Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats
- in-vivo, Pca, NA
GSH↑, SOD↑, Catalase↑, GPx↑, GSR↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, lipid-P↓, H2O2↓, Raf↓, p‑MEK↓, Bcl-2↑, Bcl-xL↑, Casp3↑, Casp8↑, Casp9↑,
3061- RES,    The Anticancer Effects of Resveratrol: Modulation of Transcription Factors
- Review, Var, NA
AhR↓, NRF2↑, *NQO1↑, *HO-1↑, *GSH↑, P53↑, Cyt‑c↑, Diablo↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, FOXO↑, p‑PI3K↓, p‑Akt↓, BIM↑, DR4↑, DR5↑, p27↑, cycD1/CCND1↓, SIRT1↑, NF-kB↓, ATF3↑,
882- RES,    Resveratrol: A Double-Edged Sword in Health Benefits
- Review, NA, NA
AntiTum↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↑, NAF1↓, NRF2↑, ROS↑, Apoptosis↑, HDAC↓, TumCCA↑, TumAuto↑, angioG↓, iNOS↓,
881- RES,    Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
- in-vitro, BC, MDA-MB-231 - in-vitro, PC, PANC1 - in-vitro, Pca, DU145
TumCCA↑, cycD1/CCND1↓, Bcl-xL↓, Mcl-1↓, other↓,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
2446- SFN,  CAP,    The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor
- in-vitro, Pca, LNCaP
AR↓, Bcl-xL↓, TumCP↓, Glycolysis↓, HK2↓, PKA↓, Hif1a↓, PSA↓, ECAR↓, BioAv↑, BioAv↓, *toxicity↓,
1469- SFN,    Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, Pca, NA
eff↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, eff↑, eff↑, eff↑, HER2/EBBR2↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, eff↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
2230- SK,    Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,
3950- Taur,    Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes
- Review, Diabetic, NA - Review, Stroke, NA - Review, AD, NA
*Ca+2↝, *neuroP↑, *other↝, *pH↝, *ROS∅, eff↑, *MMP↑, *Apoptosis↓, *other↝, *ER Stress↓, *Bcl-xL↓, *BAX↑, *Cyt‑c↑, *cal2↓, *Casp3↓, *UPR↓, *other↝, *NF-kB↓, *NRF2↑, *GLUT1↑, *GLUT3↑, *memory↑,
2353- TQ,    The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies
- Review, PC, NA
BioAv↝, BioAv↑, MUC4↓, PKM2↓, eff↑, TumVol↓, HDAC↓, NF-kB↓, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, COX2↓, PGE1↓,
2121- TQ,    Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
p‑p38↑, ROS↑, TumCP↓, eff↑, XIAP↓, survivin↓, Bcl-xL↓, Bcl-2↓, Ki-67↓, *Catalase↑, *SOD↑, *GSH↑, hepatoP↑, p‑MAPK↑, JNK↓, eff↓,
2120- TQ,    Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3
- in-vitro, Melanoma, A431
ROS↑, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp7↑, Casp3↑, STAT3↓, cycD1/CCND1↓, survivin↓, eff↓,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2↑, XIAP↓, TNF-α↓, COX2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, BioAv↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,
2085- TQ,    Anticancer Activities of Nigella Sativa (Black Cumin)
- Review, Var, NA
MMP↓, Casp3↑, Casp8↑, Casp9↓, cl‑PARP↑, Cyt‑c↑, Bax:Bcl2↑, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, cJun↑, p38↑, Akt↑, chemoP↑, *radioP↑,
2095- TQ,    Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis
- Review, Var, NA
TumCCA↑, Apoptosis↑, ROS↑, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, cl‑PARP↑, P53↑, P21↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, eff↑,
2100- TQ,    Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant
- Review, NA, NA
ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,
2102- TQ,    A review on therapeutic potential of Nigella sativa: A miracle herb
- Review, Var, NA
angioG↓, NF-kB↓, PPARγ↓, Bcl-2↓, Bcl-xL↓, MUC4↓, cJun↑, p38↑, P21↑, HDAC↓, *radioP↑, hepatoP↑,
2108- TQ,    Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
- Review, Var, NA
HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, survivin↓, COX2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,
4565- TQ,    Thymoquinone in the clinical treatment of cancer: Fact or fiction?
- Review, BC, NA
Dose↝, TumCCA↑, P21↑, cycD1/CCND1↓, TumCI↑, TumMeta↓, Bcl-2↓, Bcl-xL↓, survivin↓, PTEN↑, Akt↓, P53↑, NF-kB↓, cardioP↑, Dose↝,
3414- TQ,    Thymoquinone induces apoptosis through inhibition of JAK2/STAT3 signaling via production of ROS in human renal cancer Caki cells
- in-vitro, RCC, Caki-1
tumCV↓, Apoptosis↑, P53↑, BAX↑, Cyt‑c↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, p‑STAT3↓, p‑JAK2↓, STAT3↓, survivin↓, cycD1/CCND1↓, ROS↑, eff↓,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, BioAv↝, eff↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, eff↑, EMT↓, ROS↑, DNMT1↓, eff↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *eff↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3429- TQ,    Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells
- in-vitro, AML, NA - in-vivo, NA, NA
DNMT1↓, Sp1/3/4↓, NF-kB↓, Apoptosis↑, Casp↑, Bcl-xL↓, COX2↓, iNOS↓, 5LO↓, TNF-α↓, cycD1/CCND1↓, BioAv↝, TumCG↓,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
1838- VitK3,  PDT,    Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways
- in-vitro, Cerv, NA
eff↑, ROS↑, tumCV↓, TumCG↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-xL↑, Cyt‑c↑, Bcl-2↓,

Showing Research Papers: 101 to 132 of 132
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 132

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ATF3↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↓, 1,   GSH↑, 2,   GSR↑, 1,   H2O2↓, 1,   lipid-P↓, 2,   NAF1↓, 1,   NRF2↑, 2,   ROS↑, 15,   ROS⇅, 2,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 1,   MEK↓, 2,   p‑MEK↓, 1,   MMP↓, 6,   Raf↓, 2,   XIAP↓, 8,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↓, 1,   AMPK↑, 1,   cMyc↓, 5,   ECAR↓, 1,   FAO↑, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 2,   lactateProd↓, 2,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 2,   PPARγ↓, 2,   SIRT1↓, 1,   SIRT1↑, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AhR↓, 1,   Akt↓, 8,   Akt↑, 1,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 9,   Bak↑, 2,   BAX↑, 11,   Bax:Bcl2↑, 3,   Bcl-2↓, 23,   Bcl-2↑, 1,   Bcl-xL↓, 29,   Bcl-xL↑, 2,   BIM↓, 1,   BIM↑, 2,   Casp↑, 4,   Casp1↓, 1,   Casp3↑, 15,   cl‑Casp3↑, 2,   Casp7↑, 2,   Casp8↑, 2,   Casp9↓, 1,   Casp9↑, 8,   cl‑Casp9↑, 2,   Cyt‑c↑, 7,   Diablo↑, 1,   DR4↑, 2,   DR5↑, 2,   hTERT/TERT↓, 1,   IAP1↓, 5,   IAP2↓, 4,   IAP2↑, 1,   iNOS↓, 2,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 2,   p‑MAPK↑, 1,   Mcl-1↓, 5,   MDM2↓, 2,   NOXA↑, 1,   p27↑, 2,   p38↑, 2,   p‑p38↓, 1,   p‑p38↑, 2,   survivin↓, 15,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 2,   EZH2↓, 2,   H3↓, 1,   HATs↑, 1,   other↓, 1,   pRB↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↓, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↑, 1,   DNAdam↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   GADD45A↑, 1,   p16↑, 1,   P53↑, 13,   cl‑PARP↑, 7,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK4↓, 2,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 15,   P21↓, 1,   P21↑, 6,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cDC2↓, 1,   CSCs↓, 2,   EMT↓, 7,   ERK↓, 3,   p‑ERK↓, 4,   FOXM1↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   H3K27ac↓, 1,   HDAC↓, 8,   HDAC1↓, 2,   HDAC2↓, 2,   HDAC3↓, 1,   HDAC4↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   IGF-2↓, 1,   IGFBP3↑, 2,   miR-34a↑, 1,   mTOR↓, 4,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   PI3K↓, 6,   p‑PI3K↓, 1,   PTEN↑, 4,   STAT3↓, 8,   p‑STAT3↓, 2,   TumCG↓, 6,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   CD31↓, 2,   E-cadherin↑, 4,   FAK↓, 1,   GIT1↓, 1,   Ki-67↓, 3,   MARK4↓, 1,   MMP2↓, 3,   MMP9↓, 5,   MMPs↓, 2,   MUC4↓, 3,   N-cadherin↓, 2,   PKA↓, 1,   Rac1↓, 1,   TGF-β↓, 1,   TumCI↑, 1,   TumCP↓, 4,   TumMeta↓, 6,   Twist↓, 3,   uPA↓, 1,   Vim↓, 3,   Zeb1↓, 3,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   EGFR↓, 1,   Hif1a↓, 3,   NO↑, 1,   VEGF↓, 7,   VEGFR2/KDR/Flk1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↑, 1,   COX2↓, 8,   CXCR4↓, 3,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL10↓, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 1,   IL6↑, 1,   Inflam↓, 6,   IκB↓, 1,   JAK2↓, 1,   p‑JAK2↓, 1,   MDSCs↓, 1,   NF-kB↓, 13,   p‑p65↓, 2,   PGE1↓, 1,   PGE2↓, 1,   PSA↓, 1,   TLR4↓, 1,   TNF-α↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 3,   ChemoSen↑, 2,   Dose↝, 3,   eff↓, 5,   eff↑, 15,   Half-Life↝, 1,   RadioS↑, 2,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 3,   BRCA1↑, 1,   EGFR↓, 1,   EZH2↓, 2,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   IL6↑, 1,   Ki-67↓, 3,   Maspin↑, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 4,   chemoPv↑, 1,   hepatoP↑, 6,   neuroP↑, 2,   radioP↑, 2,   RenoP↑, 1,   TumVol↓, 2,  
Total Targets: 235

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 3,   GPx↑, 2,   GSH↑, 4,   GSTs↑, 2,   HO-1↑, 1,   MDA↓, 1,   MPO↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 3,   ROS∅, 1,   SOD↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

NAD↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↑, 1,   Bcl-xL↓, 1,   Casp3↓, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   UPR↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,   cal2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↑, 1,   GLUT3↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   CRP↓, 1,   HMGB1↓, 1,   IL1β↓, 2,   IL6↓, 2,   Inflam↓, 2,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↝, 1,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   chemoPv↑, 1,   memory↑, 2,   neuroP↑, 3,   radioP↑, 3,   toxicity↓, 1,  
Total Targets: 52

Scientific Paper Hit Count for: Bcl-xL, Bcl-xL
14 Thymoquinone
9 Apigenin (mainly Parsley)
6 Curcumin
5 Baicalein
5 Quercetin
4 Alpha-Lipoic-Acid
4 EGCG (Epigallocatechin Gallate)
3 Boswellia (frankincense)
3 Fisetin
3 Gambogic Acid
3 Ginkgetin
3 Nimbolide
3 Sulforaphane (mainly Broccoli)
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
2 Artemisinin
2 Cisplatin
2 Berbamine
2 Beta-Caryophyllene
2 Boron
2 Butyrate
2 Carnosic acid
2 Capsaicin
2 chaetocin
2 Cucurbitacin
2 Docetaxel
2 Ursolic acid
2 Ellagic acid
2 Garcinol
2 Luteolin
2 Phenylbutyrate
2 Phenethyl isothiocyanate
2 Plumbagin
2 VitK3,menadione
1 Astragalus
1 Silver-NanoParticles
1 Camptothecin
1 Anethole/trans-Anethole
1 Paclitaxel/Taxol
1 Berberine
1 Betulinic acid
1 brusatol
1 Carvacrol
1 Sorafenib (brand name Nexavar)
1 Cat’s Claw
1 Chrysin
1 Cinnamon
1 Citric Acid
1 Gemcitabine (Gemzar)
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 D-limonene
1 Emodin
1 Eurycomanone
1 Eugenol
1 Evodiamine
1 Formononetin
1 Isoliquiritigenin
1 Ginger/6-Shogaol/Gingerol
1 Honokiol
1 Hyperthermia
1 Juglone
1 Magnolol
1 Magnetic Fields
1 Niclosamide (Niclocide)
1 Neem
1 Radiotherapy/Radiation
1 Piperine
1 Piperlongumine
1 Rosmarinic acid
1 Shikonin
1 Taurine
1 Photodynamic Therapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:28  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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