Bcl-xL Cancer Research Results

Bcl-xL, Bcl-xL: Click to Expand ⟱
Source:
Type: pro-survival proteins
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL.
BCL-XL overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-XL plays essential roles in the maintenance of cancer stem cell phenotype.
Scientific Papers found: Click to Expand⟱
2100- TQ,    Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant
- Review, NA, NA
ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,
2102- TQ,    A review on therapeutic potential of Nigella sativa: A miracle herb
- Review, Var, NA
angioG↓, NF-kB↓, PPARγ↓, Bcl-2↓, Bcl-xL↓, MUC4↓, cJun↑, p38↑, P21↑, HDAC↓, *radioP↑, hepatoP↑,
2108- TQ,    Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
- Review, Var, NA
HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, survivin↓, COX2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,
2353- TQ,    The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies
- Review, PC, NA
BioAv↝, BioAv↑, MUC4↓, PKM2↓, eff↑, TumVol↓, HDAC↓, NF-kB↓, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, COX2↓, PGE1↓,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
1838- VitK3,  PDT,    Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways
- in-vitro, Cerv, NA
eff↑, ROS↑, tumCV↓, TumCG↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-xL↑, Cyt‑c↑, Bcl-2↓,

Showing Research Papers: 101 to 106 of 106
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 106

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↓, 1,   ROS↑, 3,   ROS⇅, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 1,   FAO↑, 1,   FASN↓, 1,   HK2↓, 1,   lactateProd↓, 1,   PKM2↓, 2,   PPARγ↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   Bcl-xL↓, 5,   Bcl-xL↑, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   IAP1↓, 2,   IAP2↓, 2,   JNK↑, 1,   p38↑, 1,   survivin↓, 3,  

Transcription & Epigenetics ⓘ

cJun↑, 1,   tumCV↓, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   GADD45A↑, 1,   p16↑, 1,   P53↑, 2,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 2,   P21↓, 1,   P21↑, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   HDAC↓, 4,   STAT3↓, 3,   TumCG↓, 1,  

Migration ⓘ

CD31↓, 1,   Ki-67↓, 1,   MMP9↓, 1,   MUC4↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EGFR↓, 1,   NO↑, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   Inflam↓, 1,   NF-kB↓, 5,   PGE1↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   eff↑, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   Ki-67↓, 1,  

Functional Outcomes ⓘ

hepatoP↑, 1,   neuroP↑, 1,   TumVol↓, 1,  
Total Targets: 65

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 1,   MPO↑, 1,   SOD↑, 2,  

Functional Outcomes ⓘ

chemoP↑, 1,   neuroP↑, 1,   radioP↑, 2,  
Total Targets: 10

Scientific Paper Hit Count for: Bcl-xL, Bcl-xL
14 Thymoquinone
9 Apigenin (mainly Parsley)
6 Curcumin
5 Baicalein
5 Quercetin
4 Alpha-Lipoic-Acid
4 EGCG (Epigallocatechin Gallate)
3 Boswellia (frankincense)
3 Sulforaphane (mainly Broccoli)
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
2 Artemisinin
2 Berbamine
2 Boron
2 Butyrate
2 Capsaicin
2 Ursolic acid
2 Ellagic acid
2 Fisetin
2 Garcinol
2 Luteolin
2 Phenylbutyrate
2 Phenethyl isothiocyanate
2 Plumbagin
2 VitK3,menadione
1 Astragalus
1 Silver-NanoParticles
1 Camptothecin
1 Paclitaxel
1 Cisplatin
1 Berberine
1 Betulinic acid
1 brusatol
1 Chrysin
1 Cinnamon
1 Citric Acid
1 Docetaxel
1 Dichloroacetophenone(2,2-)
1 Evodiamine
1 Emodin
1 Gambogic Acid
1 Honokiol
1 Hyperthermia
1 Juglone
1 Magnolol
1 Magnetic Fields
1 Niclosamide (Niclocide)
1 Radiotherapy/Radiation
1 Piperine
1 Piperlongumine
1 Rosmarinic acid
1 Shikonin
1 Taurine
1 Photodynamic Therapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:28  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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