survivin Cancer Research Results

survivin, BIRC5: Click to Expand ⟱
Source:
Type: antiapoptosis protein
Survivin, BIRC5 (Baculoviral IAP Repeat Containing 5) is a potent anti-apoptosis protein that is differentially expressed in cancer and therefore constitutes an important anti-cancer target [49]. Moreover, high expression of survivin plays important role in resistance to chemo- and radiotherapy and has been shown to be related to unfavorable outcome for medulloblastomas.
"Survivin" is a protein that plays a crucial role in regulating cell division and inhibiting apoptosis (programmed cell death). It is part of the inhibitor of apoptosis (IAP) family and is often overexpressed in various types of cancer.
Scientific Papers found: Click to Expand⟱
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
3486- MF,    Pulsed electromagnetic field potentiates etoposide-induced MCF-7 cell death
- in-vitro, NA, NA
ChemoSen↑, tumCV↓, cl‑PARP↑, Casp7↑, Casp9↑, survivin↓, BAX↑, DNAdam↑, ROS↑, eff↓,
4353- MF,  Chemo,    Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF-7
TumCCA↑, Apoptosis↑, eff↑, TumCCA↑, Casp↝, p‑CDK2↓, cycE/CCNE↓, Fas↑, BAX↑, survivin↓, Mcl-1↓, cl‑PARP↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑,
930- MushShi,    Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation
- in-vitro, Ovarian, NA
p‑STAT3↓, PTPN6↑, cycD1/CCND1↓, Bcl-2↓, Mcl-1↓, survivin↓, VEGF↓,
1797- NarG,    Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway
- in-vitro, BC, MDA-MB-231
TumCG↓, β-catenin/ZEB1↓, AntiTum↑, Apoptosis↑, TumCCA↑, P21↑, survivin↓,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, NA, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
6493- Nimb,    Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment
- in-vivo, CRC, HCT116 - vitro+vivo, CRC, HT29
TumCP↓, Apoptosis↑, NF-kB↓, IKKα↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, cMyc↓, cycD1/CCND1↓, MMP9↓, CXCR4↓, ICAM-1↓, VEGF↓, angioG↓, TumCG↓,
4630- OLE,    Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles
- in-vitro, BC, NA
Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Vim↓, Slug↓, E-cadherin↑, CSCs↓, P21↑, survivin↝, OCT4↑, Nanog↑, SOX4↑,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP↑, AR↓, other?,
4935- PEITC,    Phenethyl Isothiocyanate Suppresses Inhibitor of Apoptosis Family Protein Expression in Prostate Cancer Cells in Culture and In Vivo
- in-vivo, Pca, LNCaP - in-vivo, Pca, PC3
Apoptosis↑, XIAP↓, survivin↓, *BioAv↑, tumCV↓, eff↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
3597- PI,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, AD, NA - Review, Park, NA - Review, Var, NA
*NF-kB↓, *MAPK↓, *AP-1↓, *COX2↓, *NOS2↓, *IL1β↓, *TNF-α↓, *PGE2↓, *STAT3↓, *IL10↑, *IL4↓, *IL5↓, P53↑, MMP9↓, MMP2↓, cMyc↓, VEGF↓, STAT3↓, survivin↓, p65↓,
2940- PL,    Piperlongumine Induces Reactive Oxygen Species (ROS)-dependent Downregulation of Specificity Protein Transcription Factors
- in-vitro, PC, PANC1 - in-vitro, Lung, A549 - in-vitro, Kidney, 786-O - in-vitro, BC, SkBr3
ROS↑, TumCP↓, Apoptosis↑, eff↓, Sp1/3/4↓, cycD1/CCND1↓, survivin↓, cMyc↓, EGFR↓, cMET↓,
2945- PL,    Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells
- in-vitro, CRC, HCT116
ROS↑, SMAD4↑, ChemoSen↑, P53↑, P21↑, BAX↑, Bcl-2↓, survivin↓, TumCMig↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
60- QC,  EGCG,  isoFl,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, pCSCs
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, CSCs↓, Apoptosis↑, TumCMig↓, TumCI↓, CD44↓, CD133↓,
45- QC,    Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1 and Survivin Expression through Wnt/β-Catenin Signaling Pathway
- in-vitro, Colon, CX-1 - in-vitro, Colon, SW480 - in-vitro, Colon, HT-29 - in-vitro, Colon, HCT116
cycD1/CCND1↓, survivin↓, Wnt/(β-catenin)↓, tumCV↓, TumCCA↑, Apoptosis↑,
47- QC,    Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells
- in-vitro, NSCLC, H460 - in-vitro, NSCLC, A549
TRAIL↑, DR5↑, survivin↓,
77- QC,  EGCG,    The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition
- in-vitro, Pca, CD44+ - in-vitro, NA, CD133+ - in-vitro, NA, PC3 - in-vitro, NA, LNCaP
Casp3↑, Casp7↑, Bcl-2↓, survivin↓, XIAP↓, EMT↓, Vim↓, Slug↓, Snail↓, β-catenin/ZEB1↓, LEF1↓, TCF↓, eff↑, CSCs↓, TumCG↓, tumCV↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
3098- RES,    Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers
- Review, Var, NA
NOTCH2↓, Wnt↓, β-catenin/ZEB1↓, p‑SMAD2↓, p‑SMAD3↓, PTCH1↓, Smo↓, Gli1↓, E-cadherin↑, NOTCH⇅, TAC?, NKG2D↑, DR4↑, survivin↓, DR5↑, BAX↑, p27↑, cycD1/CCND1↓, Bcl-2↓, STAT3↓, STAT5↓, JAK↓, DNAdam↑, γH2AX↑,
3061- RES,    The Anticancer Effects of Resveratrol: Modulation of Transcription Factors
- Review, Var, NA
AhR↓, NRF2↑, *NQO1↑, *HO-1↑, *GSH↑, P53↑, Cyt‑c↑, Diablo↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, FOXO↑, p‑PI3K↓, p‑Akt↓, BIM↑, DR4↑, DR5↑, p27↑, cycD1/CCND1↓, SIRT1↑, NF-kB↓, ATF3↑,
2982- RES,    The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1
- in-vitro, Melanoma, MSTO-211H
tumCV↓, Apoptosis↑, Sp1/3/4↓, p27↓, P21↓, cycD1/CCND1↓, Mcl-1↓, survivin↓,
1506- RES,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
DNMTs↓, BRCA1↑, HDAC↓, SIRT1↑, p300↓, survivin↓, HDAC1↓, HDAC3↓, HDAC8↓,
104- RES,  QC,    Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a
- in-vitro, Colon, HT-29
Casp3↑, PARP↑, survivin↓, miR-27a-3p↓, Sp1/3/4↓, ZBTB10↑, ROS⇅, TAC↑, tumCV↓,
4657- RES,    Resveratrol, cancer and cancer stem cells: A review on past to future
- Review, Var, NA
CSCs↓, CD133↓, Shh↓, Twist↓, Snail↓, MMP2↓, MMP9↓, Smad1↓, CD44↓, ALDH1A1↓, OCT4↓, Nanog↓, STAT3↓, survivin↓, cycD1/CCND1↓, COX2↓, cMyc↓,
3037- RosA,    Unraveling rosmarinic acid anticancer mechanisms in oral cancer malignant transformation
- in-vitro, Oral, SCC9 - in-vitro, Oral, HSC3
survivin↓, AntiCan↑, Vim↓, Snail↓, SOX9↓, EMT↓, MMP2↓, MMP9↓, P-gp↓, TumCG↓, ROS↑, MMP↓, GSH↓, P-gp↓, ATP↓,
1747- RosA,    Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review
- Review, BC, MDA-MB-231 - Review, BC, MDA-MB-468
TumCCA↑, TNF-α↑, GADD45A↑, BNIP3↑, survivin↓, Bcl-2↓, BAX↑, HH↓, eff↑, ChemoSen↑, RadioS↑, TumCP↓, TumCMig↓, Apoptosis↑, RenoP↑, CardioT↓,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27↑, CHOP↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
5123- Sal,    Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells
- in-vitro, BC, MCF-7 - in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HEK293
Wnt↓, β-catenin/ZEB1↓, mTORC1↓, GSK‐3β↑, cycD1/CCND1↓, survivin↓, LRP6↓, TumCG↓, Apoptosis↑,
6450- SAO,    Survivin Down-regulation by α-Santalol Is Not Mediated Through PI3K-AKT Pathway in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
survivin↓,
3192- SFN,    Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention
- in-vitro, Pca, PC3
Sp1/3/4↓, selectivity↑, NRF2↑, HDAC↓, DNMTs↓, TumCCA↑, selectivity↑, HO-1↑, NQO1↑, CDK2↓, TumCP↓, BID↑, Smad1↑, Diablo↑, ICAD↑, Cyt‑c↑, IAP1↑, HSP27↑, *Cyt‑c↓, *IAP1↓, *HSP27↓, survivin↓, CDK4↓, VEGF↓, AR↓,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, eff↑, eff↑, eff↑, HER2/EBBR2↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, eff↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, eff↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31↓, Hif1a↓, VEGFR2↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
978- SIL,    A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment
- Review, NA, NA
PI3K↓, Akt↓, NF-kB↓, Wnt/(β-catenin)↓, MAPK↓, TumCP↓, TumCCA↑, Apoptosis↑, p‑EGFR↓, JAK2↓, STAT5↓, cycD1/CCND1↓, hTERT/TERT↓, AP-1↓, MMP9↓, miR-21↓, miR-155↓, Casp9↑, BID↑, ERK↓, Akt2↓, DNMT1↓, P53↑, survivin↓, Casp3↑, ROS↑,
3044- SK,    Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, survivin↓, TumCCA↓, CDK2↓, CDK4↓, XIAP↓, Casp3↑, Casp9↑, cycD1/CCND1↓, cycE/CCNE↓,
1017- SSE,    Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of β-catenin survival axis
- vitro+vivo, CRC, NA
Akt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, survivin↓, Apoptosis↑, ROS↑,
6431- T4O,    Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo
- vitro+vivo, NSCLC, A549
TumCCA↑, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, Bax:Bcl2↑, XIAP↓, survivin↓, Dose↝, Apoptosis↑, tumCV↓, Cyt‑c↑, eff↑, necrosis↑,
5332- TFdiG,    Theaflavin-3,3′-digallate triggers apoptosis in osteosarcoma cells via the caspase pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
tumCV↓, cl‑Casp3↑, cl‑Casp9↑, p‑γH2AX↑, BAX↑, Bak↑, Cyt‑c↑, Mcl-1↓, survivin↓, TumVol↓, Wnt↓, β-catenin/ZEB1↓, Dose↝, ROS↑, eff↓, TumW↓, Ki-67↓,
5334- TFdiG,    Theaflavin inhibits the malignant phenotype of human anaplastic thyroid cancer 8305C cells by regulating lipid metabolism via PI3K/AKT signaling
- in-vitro, Thyroid, 8505C
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, survivin↓, SREBP1↓, toxicity↑,

Showing Research Papers: 101 to 150 of 171
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 171

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↑, 1,   CYP1A1↓, 1,   CYP1A1↑, 2,   CYP2E1↑, 1,   GPx↑, 1,   GSH↓, 7,   GSH↑, 2,   GSTs↑, 1,   HO-1↑, 6,   lipid-P↓, 3,   lipid-P↑, 1,   MDA↑, 2,   MPO↓, 1,   NQO1↑, 2,   NRF2↑, 6,   mt-OXPHOS↓, 1,   Prx4↑, 1,   ROS↓, 1,   ROS↑, 19,   ROS⇅, 1,   ROS↝, 1,   mt-ROS↑, 1,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 1,   TAC?, 1,   TAC↑, 1,   TrxR↓, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 4,   MEK↓, 1,   MMP↓, 8,   OCR↓, 1,   Raf↓, 1,   e-Raf↓, 1,   XIAP↓, 10,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   cMyc↓, 14,   CYP3A4↓, 1,   GLO-I↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 5,   HK2↓, 4,   lactateProd↓, 1,   SIRT1↑, 2,   SREBP1↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

AhR↓, 1,   Akt↓, 10,   Akt↑, 1,   p‑Akt↓, 3,   APAF1↑, 1,   Apoptosis↓, 2,   Apoptosis↑, 22,   ASK1↑, 1,   Bak↑, 1,   BAX↑, 17,   Bax:Bcl2↑, 2,   Bcl-2↓, 20,   Bcl-2↑, 1,   Bcl-xL↓, 6,   BID↑, 3,   BIM↓, 1,   BIM↑, 2,   Casp↑, 2,   Casp↝, 1,   cl‑Casp↑, 1,   Casp10↑, 1,   Casp3↑, 20,   cl‑Casp3↑, 1,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 5,   cl‑Casp8↑, 1,   pro‑Casp8↑, 1,   Casp9↑, 13,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 10,   Cyt‑c↝, 1,   Diablo↑, 3,   DR4↑, 5,   DR5↓, 1,   DR5↑, 6,   FADD↑, 2,   Fas↑, 5,   FasL↑, 2,   hTERT/TERT↓, 1,   IAP1↑, 1,   ICAD↑, 1,   iNOS↓, 3,   JNK↑, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 3,   MAPK↑, 1,   Mcl-1↓, 10,   MDM2↓, 1,   MOMP↑, 1,   Myc↓, 1,   necrosis↑, 2,   p27↓, 1,   p27↑, 5,   p38↓, 1,   p38↑, 1,   p‑p38↓, 1,   p‑p38↑, 2,   PUMA↑, 1,   survivin↓, 49,   survivin↝, 1,   Telomerase↓, 2,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   SOX9↓, 1,   Sp1/3/4↓, 8,  

Transcription & Epigenetics ⓘ

HATs↓, 1,   HATs↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   other?, 1,   other↓, 1,   other↝, 1,   p‑pRB↓, 1,   tumCV↓, 11,  

Protein Folding & ER Stress ⓘ

CHOP↑, 5,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 2,   GRP78/BiP↓, 1,   HSP27↓, 1,   HSP27↑, 2,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

BNIP3↑, 1,   LC3II↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   DFF45↑, 1,   DNAdam↑, 4,   DNArepair↓, 1,   DNMT1↓, 1,   DNMTs↓, 2,   GADD45A↑, 1,   P53↑, 15,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 9,   PCNA↓, 5,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 4,   CDK2↓, 4,   p‑CDK2↓, 1,   CDK4↓, 6,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 5,   cycD1/CCND1↓, 21,   cycE/CCNE↓, 5,   P21↓, 1,   P21↑, 10,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 19,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   CD133↓, 2,   CD44↓, 3,   cFos↓, 1,   cMET↓, 2,   CSCs↓, 8,   EMT↓, 9,   ERK↓, 5,   ERK↑, 1,   p‑ERK↓, 2,   FOXM1↓, 1,   FOXO↑, 1,   p‑FOXO3↓, 1,   Gli1↓, 3,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   HDAC↓, 5,   HDAC1↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   LRP6↓, 1,   mTOR↓, 7,   p‑mTOR↓, 2,   mTORC1↓, 1,   Nanog↓, 2,   Nanog↑, 1,   NOTCH⇅, 1,   NOTCH1↓, 2,   NOTCH2↓, 1,   OCT4↓, 2,   OCT4↑, 1,   p300↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 8,   p‑PI3K↓, 1,   PTCH1↓, 2,   PTEN↑, 3,   PTPN6↑, 1,   RAS↓, 2,   Shh↓, 2,   Smo↓, 3,   SOX2↓, 1,   STAT1↓, 1,   STAT3↓, 12,   p‑STAT3↓, 1,   STAT5↓, 2,   STAT6↓, 1,   TCF↓, 1,   TOP2↓, 1,   TumCG↓, 9,   Wnt↓, 9,   Wnt/(β-catenin)↓, 2,  

Migration ⓘ

5LO↓, 1,   Akt2↓, 1,   AntiAg↑, 1,   AP-1↓, 3,   Ca+2↑, 1,   Ca+2↝, 1,   CD31↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 6,   FAK↓, 1,   GLI2↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   Ki-67↓, 2,   LEF1↓, 3,   miR-155↓, 1,   MMP2↓, 10,   MMP7↓, 3,   MMP9↓, 14,   MMPs↓, 5,   N-cadherin↓, 3,   RAGE↓, 1,   Slug↓, 5,   Smad1↓, 1,   Smad1↑, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   SMAD4↑, 1,   Snail↓, 9,   SOX4↑, 2,   TGF-β↓, 2,   TIMP1↑, 2,   TIMP2↑, 3,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 10,   TumCMig↓, 9,   TumCP↓, 16,   TumMeta↓, 10,   TumMeta↑, 1,   Twist↓, 4,   uPA↓, 2,   VCAM-1↓, 2,   Vim↓, 7,   Zeb1↓, 2,   β-catenin/ZEB1↓, 14,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 13,   ATF4↑, 1,   ATF4↝, 1,   EGFR↓, 8,   p‑EGFR↓, 1,   Hif1a↓, 8,   LOX1↓, 1,   VEGF↓, 14,   VEGFR2↓, 1,   ZBTB10↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↓, 1,   P-gp↓, 5,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 11,   CXCR2↓, 2,   CXCR4↓, 8,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   IKKα↓, 5,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL1β↓, 3,   IL2↑, 1,   IL6↓, 5,   IL8↓, 2,   Inflam↓, 6,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 3,   MDSCs↓, 1,   NF-kB↓, 15,   p50↓, 1,   p65↓, 1,   PGE2↓, 1,   PSA↓, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 3,   CDK6↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 3,   BioEnh?, 1,   BioEnh↑, 1,   ChemoSen↑, 10,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose↓, 1,   Dose↝, 7,   eff↓, 4,   eff↑, 15,   eff↝, 1,   Half-Life↝, 2,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   P450↓, 2,   RadioS↑, 3,   selectivity↑, 6,  

Clinical Biomarkers ⓘ

AR↓, 3,   BRCA1↑, 1,   EGFR↓, 8,   p‑EGFR↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 5,   Ki-67↓, 2,   Myc↓, 1,   PSA↓, 1,   RAGE↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiTum↑, 2,   cardioP↑, 2,   CardioT↓, 1,   chemoP↑, 5,   chemoPv↑, 2,   hepatoP↑, 3,   neuroP↑, 1,   NKG2D↑, 1,   radioP↑, 2,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity↑, 1,   TumVol↓, 2,   TumW↓, 2,  
Total Targets: 365

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 4,   GPx1↑, 1,   GSH↑, 3,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 3,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 3,   ROS↓, 5,   ROS↑, 1,   SOD1↑, 1,   SOD2↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↓, 1,  

Core Metabolism/Glycolysis ⓘ

FASN↓, 1,  

Cell Death ⓘ

Cyt‑c↓, 1,   IAP1↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Protein Folding & ER Stress ⓘ

HSP27↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,  

Migration ⓘ

AntiAg↑, 2,   AP-1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 2,   IL4↓, 1,   IL5↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 2,   Dose↝, 3,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

IL6↓, 2,   NOS2↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   hepatoP↑, 2,   neuroP↑, 1,   radioP↑, 1,   toxicity↓, 2,   toxicity↝, 1,  
Total Targets: 50

Scientific Paper Hit Count for: survivin, BIRC5
19 Thymoquinone
8 Resveratrol
7 Curcumin
7 EGCG (Epigallocatechin Gallate)
7 Quercetin
6 Silymarin (Milk Thistle) silibinin
4 Artemisinin
4 Ashwagandha(Withaferin A)
4 Baicalein
4 Boswellia (frankincense)
4 Sulforaphane (mainly Broccoli)
4 Fisetin
4 Honokiol
4 Piperlongumine
3 Apigenin (mainly Parsley)
3 Berbamine
3 Berberine
3 Beta-Caryophyllene
3 Betulinic acid
3 Capsaicin
3 Deguelin
3 Eugenol
3 Gambogic Acid
3 Garcinol
3 Nimbolide
2 1,8-Cineole
2 5-fluorouracil
2 Silver-NanoParticles
2 Alpha-Lipoic-Acid
2 Cisplatin
2 immunotherapy
2 Docetaxel
2 Carnosic acid
2 Chemotherapy
2 Cucurbitacin
2 Ellagic acid
2 Geraniol
2 Luteolin
2 Lycopene
2 Magnetic Fields
2 Naringin
2 Phenethyl isothiocyanate
2 Rosmarinic acid
2 salinomycin
2 Aflavin-3,3′-digallate
1 Coenzyme Q10
1 Andrographis
1 Gemcitabine (Gemzar)
1 chitosan
1 Bufalin/Huachansu
1 brusatol
1 Bruteridin(bergamot juice)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Propolis -bee glue
1 Celastrol
1 Chlorophyllin
1 Chrysin
1 Cinnamon
1 Citric Acid
1 Radiotherapy/Radiation
1 Dichloroacetate
1 Dandelion Root
1 Genistein (soy isoflavone)
1 Butyrate
1 Emodin
1 Eurycomanone
1 Fucoidan
1 Fennel Oil/Foeniculum vulgare
1 doxorubicin
1 Magnolol
1 HydroxyTyrosol
1 Mushroom Shiitake, AHCC
1 Oleuropein
1 Phenylbutyrate
1 Piperine
1 isoflavones
1 α-Santalol/Sandalwood oil
1 Shikonin
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Ursolic acid
1 Urolithin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:299  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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