survivin Cancer Research Results

survivin, BIRC5: Click to Expand ⟱
Source:
Type: antiapoptosis protein
Survivin, BIRC5 (Baculoviral IAP Repeat Containing 5) is a potent anti-apoptosis protein that is differentially expressed in cancer and therefore constitutes an important anti-cancer target [49]. Moreover, high expression of survivin plays important role in resistance to chemo- and radiotherapy and has been shown to be related to unfavorable outcome for medulloblastomas.
"Survivin" is a protein that plays a crucial role in regulating cell division and inhibiting apoptosis (programmed cell death). It is part of the inhibitor of apoptosis (IAP) family and is often overexpressed in various types of cancer.
Scientific Papers found: Click to Expand⟱
7058- GamB,  docx,    Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells
- in-vitro, GC, BGC-823
ChemoSen↑, TumCCA↑, survivin↓,
7067- GamB,    Gambogic Acid and Its Role in Chronic Diseases
- Review, Var, NA
*NF-kB↓, PI3K↓, Akt↓, STAT3↓, STAT5↓, IL6↓, COX2/PTGS2↓, iNOS↓, MMPs↓, Src↓, PKA↓, CXCR4↑, VEGF↓, Bcl-2↓, Bcl-xL↓, IAP1↓, Mcl-1↓, survivin↓, cycD1/CCND1↓, HSP90↓, HSP70/HSPA5↓, MAPK↓, HATs↓, HDAC↓, FAK↓, ROS↑, MMP7↓, MMP9↓, α-tubulin↑, cl‑PARP↑, TNF-α↓, BID↑, BAD↑, Cyt‑c↑, Casp3↑, Casp9↑, *AntiArt↑, *antiPs↑,
7086- GAR,    Garcinol: An emerging epigenetic modifier with versatile anticancer properties
- Review, Var, NA
AntiCan↑, TumCG↓, TumMeta↓, toxicity↓, Apoptosis↑, angioG↓, *BioAv↝, HATs↓, p300↓, CBP↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, mTOR↓, DFF45↓, survivin↓, N-cadherin↓, Twist↓, MMP2↓, MMP3↓, MMP9↓, Mcl-1↓, EZH2↓, NOTCH↓, CXCR4↓, PGE2↓, VEGF↓, mPGES-1↓, CycB/CCNB1↓, CDK2↓, CDK4/6↓, iNOS↓, COX2/PTGS2↓, IL1↓, TNF-α↓, PARP↑, Bcl-2↓, CompStab↝,
801- GAR,  Cisplatin,    Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
- in-vivo, HNSCC, NA
Apoptosis↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, VEGF↓, TumCG↓, Ki-67↓, CD31/PECAM-1↓,
823- GAR,    Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, CRC, HCT116
Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,
826- GAR,    Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
- vitro+vivo, HCC, HepG2 - vitro+vivo, Liver, HUH7
STAT3↓, TumCP↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCCA↑, TumVol↓,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1/ATG6↓, *antiAll↑,
6570- Ger,    Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells
- in-vitro, Thyroid, TPC-1
*Inflam↓, AntiCan↑, *neuroP↑, tumCV↓, TumCP↓, ROS↑, Apoptosis?, MMP↓, Bcl-2↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, TNF-α↓, NF-kB↓, IL6↓, survivin↓, BAX↑, Casp3↑, JAK2↓, STAT3↓, ERK↓,
7139- GI,    6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer
- vitro+vivo, Lung, A549 - in-vitro, Melanoma, A375 - in-vitro, GBM, U251
HSP60/HSPD1↓, Apoptosis↑, TumCCA↑, mtDam↑, ERK↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, TumCG↓, TumCP↓, TumCG↓, Bcl-2↓, survivin↓, BAX↑, MMP↓, Dose↝,
7138- GI,    6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, Liver, HepG2 - in-vitro, Lung, A549
TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2/PTGS2↓, IAP1↓, Dose?,
7137- GI,    6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - vitro+vivo, Pca, HMVP2
STAT3↓, TNF-α↓, NF-kB↓, cycD1/CCND1↓, survivin↓, cMyc↓, IL7↓, RANTES↓, BAX↑, Bcl-2↓, P21↑, p27/CDKN1B↑, SOCS1↑, IRF1↑, eff↑, TumVol↓, TumW↓, toxicity↓,
7245- Gink,    Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
- vitro+vivo, Pca, DU145 - in-vitro, CRC, HCT116 - in-vitro, Nor, MCF10
STAT3↓, cycD1/CCND1↓, survivin↓, Bcl-2↓, Bcl-xL↓, TumCG↓, Dose↝, TumCCA↑, Apoptosis↑, TumVol↓, TumW↓,
7246- Gink,    Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma
- in-vitro, GC, DAOY - in-vitro, MB, D283
Wnt↓, tumCV↓, TumCCA↑, Axin2↓, cycD1/CCND1↓, survivin↓, β-catenin/ZEB1↓,
7247- Gink,    Ginkgetin inhibits growth of breast carcinoma via regulating MAPKs pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT474 - vitro+vivo, BC, MCF7
TumCP↓, Apoptosis↑, TumCG↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, survivin↓, p‑ERK↑, cl‑JNK↑,
7258- Gink,    Ginkgetin inhibits the growth of DU−145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
- vitro+vivo, Pca, DU145 - in-vitro, CRC, HCT116
STAT3↓, survivin↓, TumCCA↑, TumCG↓, Dose↝,
7259- Gink,    Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells
- in-vitro, Pca, PC3
tumCV↓, TumCCA↑, Casp3↑, Bcl-2↓, Bcl-xL↓, survivin↓, cycD1/CCND1↓, cl‑PARP↑,
7260- Gink,    Ginkgetin: A natural biflavone with versatile pharmacological activities
- Review, Var, NA - Review, Stroke, NA - Review, AD, NA
*AntiCan↑, *Inflam↓, *AntiBio↑, *neuroP↑, *TumCCA↑, Apoptosis↑, TumAuto↑, iNOS↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PLA2↓, *neuroP↑, *Stroke↓, *AntiFungal↓, *Bacteria↓, Bcl-xL↓, Bcl-2↓, Casp9↑, Casp3↑, cl‑PARP↑, IL6↓, STAT3↓, JAK1↓, survivin↓, COX2/PTGS2↓, IAP1↓, MMP2↓, MMP9↓, PTEN↑, SHP1↑, Synergy↑, TumVol↓, TumW↓, *toxicity↓, *ROS↓,
7327- GSE,    Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats
- in-vivo, CRC, NA
chemoPv↑, TumCP↓, Apoptosis↑, cycD1/CCND1↓, COX2/PTGS2↓, iNOS↓, survivin↓, β-catenin/ZEB1↓, NF-kB↓, Risk↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
4522- HNK,  MAG,    Honokiol Is More Potent than Magnolol in Reducing Head and Neck Cancer Cell Growth
- in-vitro, HNSCC, FaDu
AntiCan↑, tumCV↓, eff↑, survivin↓, RadioS↑,
4659- HNK,    Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/β-Catenin Signaling and Apoptosis Induction
- in-vitro, Oral, NA
cl‑Casp3↑, survivin↓, Bcl-2↓, CD44↓, Wnt↓, β-catenin/ZEB1↑, EMT↓, Slug↓, Snail↓, CSCs↓, Apoptosis↑,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
7591- I3C,    Indole-3-carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway
- in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, XIAP↓, IAP1↓, survivin↓, Diablo↑, Cyt‑c↑, HTRA2/Omi/PARK13↑, mtDam↑, Fas↑, FasL↑,
7774- IBC,    Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
TumCP↓, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, BAX↑, XIAP↓, survivin↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, GSK‐3β↓,
7681- iod,  mCHEMO,    Molecular Iodine Improves the Efficacy and Reduces the Side Effects of Metronomic Cyclophosphamide Treatment against Mammary Cancer Progression
- in-vivo, BC, NA
tumCV↓, Imm↑, chemoP↑, Weight↑, TumCG↓, VEGF↓, survivin↓, ChemoSen↑,
7747- ISL,    Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells
- in-vitro, Melanoma, SK-MEL-28
*Inflam↓, *AntiViral↑, *AntiTum↑, *antiOx↑, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Cyt‑c↑, cycD1/CCND1↓, cycD1/CCND1↓, survivin↓, ROS↓, eff↓, p‑mTOR↓, p‑STAT3↓, p‑MAPK↓,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
8006- JG,  VitC,    Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
TumCP↓, ROS↑, antiOx⇅, Bcl-2↓, survivin↓, BAX↑, Trx2↓, Synergy↑,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8151- lamb,    Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid
- in-vitro, BC, MCF7 - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCCA↑, cl‑PARP↑, p‑STAT3↓, NF-kB↓, XIAP?, survivin↓, Bcl-2↓, Bcl-xL↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ac‑p65↑, Obesity↓, miR-134↑,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,
8244- LCA,    Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest
- in-vitro, Liver, HepG2
TumCP↓, ROS↑, TumCCA↑, Apoptosis↑, survivin↓, CycB/CCNB1↓, CDK1↓, WEE1↑, P21↑, cycD1/CCND1↑, JNK↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, Casp3↑, Casp8↑, Casp10↑, Fas↑, BAD↑, BAX↑, PUMA↑, PKCδ↓, P70S6K↓, Akt↓,
8253- LCA,    Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma
- in-vitro, SCC, HSC4
*AntiTum↑, *angioG↓, *AntiP↑, *antiOx↑, *Bacteria↓, *Inflam↓, tumCV↓, Sp1/3/4↓, p27/CDKN1B↑, P21↑, cycD1/CCND1↓, Mcl-1↓, survivin↓, Apoptosis↑,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8341- LDN,    Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy
- Review, Var, NA
OGFr↑, TumCP↓, TumCCA↑, Apoptosis↑, toxicity↝, Half-Life↝, *FasL↓, *Fas↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, survivin↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, ChemoSen↑, chemoP↑, Synergy↑, QoL∅,
8337- LDN,    Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis by increasing M1-type macrophages and activating the Bax/Bcl-2/caspase-3/PARP pathway
- in-vitro, CRC, NA
OGFr↑, BAX↑, Casp9↑, Casp3↑, PARP↑, Bcl-2↓, survivin↓, Ki-67↓, Apoptosis↑,
8288- LE,    18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration
- vitro+vivo, CRC, NA
TumCP↓, survivin↓, cl‑PARP↑, TumCMig↓, Wound Healing↓, TumCI↓, MMPs↓, p‑PI3K↓, p‑Akt↓, p‑STAT↓,
8282- LE,    Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis
- in-vitro, GC, MGC803 - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
Ingr↝, TumCP↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, BAX↑, PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, Bcl-2↓, survivin↓, p65↓, p‑PI3K↓, p‑Akt↓,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
2924- LT,    Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1
- in-vitro, GC, NA - in-vivo, NA, NA
p‑STAT3↓, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, HSP90↓,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
4779- Lyco,    Lycopene Inhibits Reactive Oxygen Species-Mediated NF-κB Signaling and Induces Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, PANC1
ROS↓, NF-kB↓, tumCV↓, Casp3↑, Apoptosis↑, OCR↓, MMP↓, CIP2A↓, survivin↓, Casp3↑, Bax:Bcl2↑,
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2/PTGS2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
8513- MAG,    Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I
- vitro+vivo, Oral, SCC4 - in-vitro, Tong, SCC9 - in-vitro, SCC, CAL27
TumCG↓, TumMeta↓, *toxicity↓, Ingr?, chemoPv↑, compI↓, mitResp↓, ETC↓, AMPK↑, STAT3↓, ox-PrxI↑, Dose↝, Ki-67↓, STAT3↓, P70S6K↓, HK2↓, survivin↓, BioAv↝, Half-Life↝, ROS↑,
8506- MAG,    Magnolia officinalis Lignans induce apoptosis and epigenetic reprogramming via the miR-148a-3p/DNMT-1/UTF-1 axis in pancreatic cancer cells
- in-vitro, PC, Panc02 - in-vitro, PC, MIA PaCa-2
*Inflam↓, *antiOx↑, Ingr↝, tumCV↓, Apoptosis↑, ROS↑, MMP↓, Casp↑, selectivity↑, DNMT1↓, JAK2↓, STAT3↓, miR-148a↑, UTF1↑, IL6↓, survivin↓,
8572- Matr,    Matrine induces mitochondrial apoptosis in cisplatin-resistant non-small cell lung cancer cells via suppression of β-catenin/survivin signaling
- in-vitro, Lung, A549 - in-vitro, Lung, H460
Dose?, β-catenin/ZEB1↓, survivin↓, MMP↓, Casp9↑, Casp3↑,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, eff↑, survivin↓, XIAP↓, Synergy↑,

Showing Research Papers: 101 to 150 of 241
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 241

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 1,   antiOx⇅, 1,   Catalase↓, 1,   Copper↑, 1,   Fenton↑, 1,   frataxin↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 14,   GSH↑, 2,   GSTs↑, 2,   HO-1↓, 5,   HO-1↑, 9,   HO-2↓, 1,   lipid-P↓, 3,   lipid-P↑, 3,   MDA↑, 2,   MPO↓, 1,   NQO1↑, 3,   NRF2↓, 7,   NRF2↑, 13,   Prx4↑, 1,   ox-PrxI↑, 1,   ROS↓, 9,   ROS↑, 97,   ROS⇅, 5,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   mt-ROS↑, 3,   SOD↓, 2,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 1,   TAC?, 1,   TAC↑, 1,   Thiols↓, 1,   Trx2↓, 1,   TrxR↓, 3,   TrxR1↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 7,   CDC25↓, 11,   compI↓, 1,   compIII↓, 1,   ETC↓, 1,   HSP60/HSPD1↓, 3,   HTRA2/Omi/PARK13↑, 1,   MCU↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↑, 5,   OCR↓, 4,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   PDH↑, 2,   PDH↝, 1,   PHB↑, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↑, 2,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 10,   ATP↓, 11,   ECAR↝, 1,   FASN↓, 1,   FBI-1↓, 1,   GLO-I↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 11,   GSK‐3β↓, 10,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 4,   HK2↓, 7,   HMG-CoA↓, 1,   lactateProd↓, 3,   LDHA↓, 1,   lipoGen↓, 1,   NADPH↓, 1,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   PKM2↓, 2,   PLA2↓, 1,   SIRT1↓, 4,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 6,   Apoptosis?, 1,   Apoptosis↓, 4,   Apoptosis↑, 116,   mt-Apoptosis↑, 2,   ASK1↑, 1,   BAD↓, 2,   BAD↑, 5,   Bak↑, 5,   BAX↓, 1,   BAX↑, 70,   BAX⇅, 1,   Bax:Bcl2↑, 16,   Bcl-2↓, 115,   Bcl-2↑, 4,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 57,   Bcl-xL↝, 1,   BID↓, 3,   BID↑, 6,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 4,   BNIP3↑, 1,   Casp↑, 22,   Casp↝, 2,   cl‑Casp↑, 1,   Casp10↑, 3,   Casp3?, 1,   Casp3↓, 2,   Casp3↑, 90,   cl‑Casp3↑, 14,   cl‑Casp3⇅, 1,   proCasp3↑, 2,   pro‑Casp3↝, 1,   Casp7?, 1,   Casp7↑, 17,   cl‑Casp7↑, 3,   Casp8↑, 24,   cl‑Casp8↑, 5,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 56,   cl‑Casp9↑, 8,   proCasp9↑, 1,   cFLIP↓, 5,   Cyt‑c↓, 1,   Cyt‑c↑, 50,   Cyt‑c↝, 1,   cl‑Cyt‑c↑, 1,   Diablo↑, 11,   DR5↓, 1,   DR5↑, 21,   FADD↑, 4,   Fas↓, 1,   Fas↑, 13,   FasL↑, 7,   Ferroptosis↑, 4,   IAP1↓, 21,   IAP1↑, 1,   IAP2/BIRC3↓, 9,   IAP2/BIRC3↑, 1,   ICAD↓, 2,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 12,   Mcl-1?, 1,   Mcl-1↓, 33,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 12,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   necrosis↑, 2,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 5,   p38↑, 15,   p‑p38↓, 2,   p‑p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 6,   Pyro↑, 1,   survivin↓, 238,   survivin↑, 1,   survivin↝, 2,   TNFR 1↑, 2,   TRAIL↑, 3,   TRAILR↑, 2,   TumCD↑, 1,   XIAP?, 1,   XIAP↓, 63,   XIAP↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 63,   Akt↑, 6,   p‑Akt↓, 14,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 1,   CaMKII ↓, 1,   CIP2A↓, 2,   CK2↓, 2,   cMET↓, 5,   p‑cMET↑, 1,   p‑CREB↑, 1,   cSrc↓, 3,   EF-1α↓, 1,   EGFR↓, 19,   p‑EGFR↓, 1,   ERK↓, 21,   ERK↑, 3,   p‑ERK↓, 6,   p‑ERK↑, 3,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   IGFR↓, 1,   IKKα↓, 12,   IκB↓, 2,   IκB↑, 1,   JAK↓, 4,   JAK1↓, 5,   JAK2↓, 17,   p‑JAK2↓, 1,   JNK↓, 6,   JNK↑, 14,   p‑JNK↓, 1,   p‑JNK↑, 1,   cl‑JNK↑, 1,   MAPK↓, 12,   MAPK↑, 6,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 1,   mTOR↓, 39,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 5,   mTORC2↓, 1,   NIK↓, 1,   p70S6↑, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   PI3K↓, 42,   PI3K↑, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 2,   PIAS-3↑, 1,   PKA↓, 1,   PKCδ↓, 8,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 17,   PTPN6↑, 1,   Raf↓, 2,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 5,   RIP1↓, 1,   p‑RSK↑, 1,   SHP1↑, 3,   Sp1/3/4↓, 16,   Src↓, 3,   c-Src↓, 1,   STAT↓, 3,   p‑STAT↓, 1,   STAT3↓, 61,   p‑STAT3↓, 12,   p‑STAT3↑, 1,   STAT5↓, 3,   STAT6↓, 1,   STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 1,   ATF4↑, 2,   ATF4↝, 1,   CBP↓, 1,   cJun↑, 2,   cMyc↓, 42,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 5,   DNMTs↓, 7,   EZH2↓, 2,   FOXM1↓, 4,   FOXO↑, 4,   FOXO1↑, 2,   FOXO3↑, 4,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↑, 1,   H3↑, 1,   p‑H3↓, 2,   ac‑H3↑, 2,   H4↑, 2,   ac‑H4↑, 1,   HATs↓, 4,   HATs↑, 2,   HDAC↓, 18,   HDAC1↓, 4,   HDAC2↓, 1,   HDAC3↓, 3,   HDAC6↓, 2,   HDAC8↓, 2,   HES1↓, 2,   IRF1↑, 1,   miR-134↑, 1,   miR-148a↑, 1,   miR-155↓, 1,   miR-200b↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   miR-34a↑, 1,   miR-34b-5p↑, 1,   miR-375↑, 1,   miR-384↑, 1,   miR-409-3p↑, 1,   Myc↓, 5,   n-MYC↓, 1,   OCT4↓, 11,   OCT4↑, 1,   other?, 1,   other↓, 2,   other↑, 1,   other↝, 5,   SOX2↓, 3,   SOX4↓, 1,   SOX4↑, 2,   SOX9↓, 2,   tumCV↓, 39,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 13,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 13,   GRP78/BiP↓, 1,   GRP78/BiP↑, 4,   HSP27↓, 1,   HSP27↑, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 9,   HTRA↓, 2,   IRE1↑, 1,   PERK↑, 4,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 3,   LC3II↑, 5,   LC3s↑, 2,   p62↓, 3,   p62↑, 1,   RUBCN↓, 1,   TumAuto↑, 19,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 22,   DNArepair↓, 1,   ERCC1↓, 2,   HR↓, 1,   hTERT/TERT↓, 4,   MGMT↓, 1,   p16↑, 4,   P53↓, 1,   P53↑, 58,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 4,   p53 Wildtype↓, 1,   PARP↑, 12,   cl‑PARP↑, 61,   PARP1↓, 1,   PARP1↑, 1,   PCNA↓, 17,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 8,   TOP1↓, 1,   TOP2↓, 3,   UHRF1↓, 1,   γH2AX↑, 6,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1?, 1,   CDK1↓, 9,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 17,   CDK2↑, 2,   p‑CDK2↓, 1,   CDK4↓, 17,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 10,   CDK6↑, 1,   CDK8↓, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 16,   cycD1/CCND1↓, 83,   cycD1/CCND1↑, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 13,   cycE1↓, 1,   E2Fs↓, 5,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 19,   MAD↓, 1,   mitA↑, 2,   P21?, 1,   P21↓, 4,   P21↑, 44,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 19,   PLK1↓, 1,   pRB↑, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 4,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 82,   WEE1↑, 4,   β-Tubulin↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 1,   ALDH1A1↓, 3,   Axin2↓, 1,   Axin2↑, 1,   CD133↓, 5,   CD34↓, 1,   cFos↓, 2,   CSCs↓, 22,   Diff↑, 1,   Gli↓, 1,   Gli1↓, 6,   HH↓, 4,   IGF-1↓, 1,   IGFBP3↑, 1,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 19,   Let-7↑, 1,   LRP6↓, 1,   mTORC1↓, 3,   Nanog↓, 9,   Nanog↑, 1,   Nestin↓, 1,   NICD↓, 1,   NOTCH↓, 9,   NOTCH↑, 1,   NOTCH⇅, 1,   NOTCH1↓, 7,   NOTCH2↓, 1,   NOTCH3↓, 1,   OGFr↑, 2,   p300↓, 2,   PTCH1↓, 5,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 4,   STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TumCG↓, 50,   TumCG↑, 1,   TumCP↓, 74,   Wnt↓, 19,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 9,   Ca+2↓, 3,   Ca+2↑, 9,   Ca+2↝, 2,   CAFs/TAFs↓, 1,   cal2↓, 1,   Cav1↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   COL1↓, 1,   COL3A1↓, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 15,   EM↑, 1,   EMT↓, 32,   EMT↑, 1,   EpCAM↓, 1,   FAK↓, 10,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 2,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB3↓, 1,   ITGB6↓, 1,   LEF1↓, 3,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP16↓, 1,   MMP2↓, 40,   MMP3↓, 4,   MMP7↓, 7,   MMP9↓, 55,   MMPs↓, 17,   MUC4↓, 3,   N-cadherin↓, 11,   NCAM↑, 1,   pax↓, 1,   PDGF↓, 2,   Rac1↓, 2,   RECK↑, 1,   Rho↓, 3,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 12,   Smad1↓, 1,   Smad1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD3↓, 1,   SMAD4↑, 1,   Snail↓, 22,   TET1↓, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TIMP1↑, 6,   TIMP2↑, 9,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 39,   TumCI↑, 1,   TumCMig↓, 30,   TumMeta↓, 37,   TumMeta↑, 3,   Twist↓, 14,   uPA↓, 9,   uPAR↓, 1,   Vim↓, 19,   Zeb1↓, 8,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 29,   β-catenin/ZEB1↑, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 54,   angioG↑, 1,   CD31/PECAM-1↓, 3,   Endoglin↑, 1,   HIF-1↓, 3,   Hif1a↓, 26,   LOX1↓, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 3,   VEGF↓, 71,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GLUT1↓, 4,   GLUT4↓, 1,   MMP↓, 48,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 8,   COX1↓, 1,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR2↓, 2,   CXCR4↓, 16,   CXCR4↑, 1,   DR4↑, 7,   FOXP3↑, 1,   ICAM-1↓, 8,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 5,   IL10↓, 3,   IL12↓, 2,   IL1β↓, 6,   IL2↑, 2,   IL6↓, 23,   IL7↓, 1,   IL8↓, 4,   Imm↑, 3,   Imm↝, 1,   Inflam↓, 17,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 87,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 2,   NLRP3↑, 1,   p50↓, 1,   p65↓, 6,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 8,   PSA↓, 3,   RAGE↓, 1,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 1,   TCF↓, 2,   TLR4↝, 1,   TNF-α↓, 17,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   e-pH↑, 1,   i-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 9,   ER-α36↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 14,   BioAv↑, 19,   BioAv↝, 7,   BioEnh?, 1,   BioEnh↑, 2,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 71,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP1B1↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 3,   Dose↓, 1,   Dose↝, 29,   Dose∅, 2,   eff↓, 24,   eff↑, 34,   eff↝, 4,   GSTP1/GSTπ↓, 1,   GSTZ1↓, 1,   Half-Life↓, 6,   Half-Life↝, 7,   MDR1↓, 5,   MRP↓, 1,   MRP1/ABCC1↓, 1,   NAT↓, 1,   P-gp/ABCB1↓, 14,   P450↓, 2,   RadioS↑, 17,   selectivity?, 1,   selectivity↑, 32,   Synergy↑, 38,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AR↓, 9,   ascitic↓, 1,   BG↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   EGFR↓, 19,   p‑EGFR↓, 1,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 4,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 23,   LDH↓, 1,   Myc↓, 5,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 3,   PSADT↑, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 17,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↑, 3,   cachexia↓, 1,   cardioP↑, 3,   CardioT↓, 1,   chemoP?, 1,   chemoP↑, 13,   chemoPv↑, 11,   ChemoSideEff↓, 1,   fatigue↓, 1,   hepatoP↑, 6,   neuroP↑, 2,   NKG2D↑, 1,   Obesity↓, 1,   OS↑, 1,   QoL∅, 1,   radioP↑, 2,   RenoP↑, 3,   Risk↓, 5,   TGFβR1↓, 1,   toxicity↓, 10,   toxicity↑, 1,   toxicity↝, 3,   TumVol↓, 20,   TumW↓, 10,   Weight↑, 1,   Weight∅, 2,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 4,  
Total Targets: 776

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 1,   antiOx↑, 24,   ARE↑, 1,   Catalase↑, 9,   GPx↑, 8,   GPx1↑, 1,   GSH↑, 7,   GSTs↑, 4,   HO-1?, 1,   HO-1↑, 4,   lipid-P↓, 8,   MDA↓, 4,   MPO↑, 1,   NQO1↑, 2,   NRF2?, 1,   NRF2↑, 8,   ROS↓, 26,   ROS↑, 1,   ROS∅, 3,   SOD↑, 11,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   5LO↝, 1,   ALAT↓, 2,   AMPK↑, 1,   FASN↓, 1,   glucose↝, 1,   GSK‐3β↓, 1,   NAD↑, 1,   NADPH↑, 3,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Cyt‑c↓, 1,   Fas↓, 1,   FasL↓, 1,   IAP1↓, 1,   iNOS↓, 3,   p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑Akt↑, 1,   JAK2↑, 1,   p‑JNK↓, 1,   MAPK↓, 2,   mTOR↑, 1,   PI3K↑, 1,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HOTAIR↑, 1,   other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP27↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 1,   MMP13↓, 1,   MMP3↓, 1,   TGF-β↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   NO↓, 4,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MUC5AC↓, 1,   TRPA1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 8,   HMGB1↓, 1,   IL1↓, 1,   IL10↑, 1,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 8,   IL4↓, 1,   IL5↓, 1,   IL6↓, 9,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 26,   Inflam↑, 1,   NF-kB↓, 10,   PGE2↓, 4,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 10,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,   tau↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 6,   BioAv↝, 6,   CompStab↑, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 1,   GSTA1↑, 1,   Half-Life↝, 5,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   CRP↓, 1,   IL6↓, 9,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   antiAll↑, 8,   AntiArt↑, 4,   AntiCan↑, 5,   AntiDiabetic↑, 2,   antiPs↑, 1,   AntiTum↑, 3,   cardioP↑, 7,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 7,   memory↑, 1,   neuroP↑, 17,   Obesity↓, 2,   Pain↓, 1,   radioP↑, 3,   Stroke↓, 1,   toxicity↓, 11,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiP↑, 2,   AntiViral↑, 6,   Bacteria↓, 5,   Bacteria↑, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 151

Scientific Paper Hit Count for: survivin, BIRC5
19 Thymoquinone
8 Resveratrol
7 Curcumin
7 EGCG (Epigallocatechin Gallate)
7 Quercetin
6 Sulforaphane (mainly Broccoli)
6 Gambogic Acid
6 Ginkgetin
6 Silymarin (Milk Thistle) silibinin
5 Matrine
4 Artemisinin
4 Ashwagandha(Withaferin A)
4 Baicalein
4 Boswellia (frankincense)
4 Fisetin
4 Garcinol
4 Honokiol
4 Licochalcone A
4 Nimbolide
4 Marjoram (Origanum majorana)
4 Piperlongumine
3 Cisplatin
3 Apigenin (mainly Parsley)
3 Docetaxel
3 Berbamine
3 Berberine
3 Beta-Caryophyllene
3 Betulinic acid
3 Benzyl isothiocyanate
3 Phenethyl isothiocyanate
3 Capsaicin
3 Deguelin
3 Eugenol
3 Ginger/6-Shogaol/Gingerol
3 Magnolol
3 Luteolin
3 Magnetic Fields
3 Morin
2 1,8-Cineole
2 5-fluorouracil
2 Silver-NanoParticles
2 Allyl isothiocyanate
2 Alpha-Lipoic-Acid
2 immunotherapy
2 Carnosic acid
2 Chemotherapy
2 Cucurbitacin
2 Dichloroacetate
2 Ellagic acid
2 Emodin
2 Fucoidan
2 doxorubicin
2 Geraniol
2 Isoliquiritigenin
2 lambertianic acid
2 low dose naltrexone
2 Licorice
2 Lycopene
2 Mangiferin
2 Naringin
2 Terpinen-4-ol / Tea Tree Oil
2 Rosmarinic acid
2 salinomycin
2 Aflavin-3,3′-digallate
1 Coenzyme Q10
1 Açaí, Euterpe oleracea
1 Andrographis
1 Gemcitabine (Gemzar)
1 chitosan
1 Bufalin/Huachansu
1 Isothiocyanates
1 brusatol
1 Bruteridin(bergamot juice)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Propolis -bee glue
1 Celastrol
1 chaetocin
1 Chlorophyllin
1 Chrysin
1 Cinnamon
1 Citric Acid
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Radiotherapy/Radiation
1 Cynaropicrin
1 Dandelion Root
1 Butyrate
1 Genistein (soy isoflavone)
1 Eurycomanone
1 Fennel Oil/Foeniculum vulgare
1 Flaxseed/Linseed
1 Grapeseed extract
1 HydroxyTyrosol
1 Indole-3-carbinol
1 Isobavachalcone
1 iodine
1 MCT, metronomic chemo
1 Juglone
1 Vitamin C (Ascorbic Acid)
1 Kaempferol
1 Methyl Jasmonate
1 Moringin
1 Melatonin
1 Mushroom Shiitake, AHCC
1 Neem
1 Oleuropein
1 Phenylbutyrate
1 Purple Corn / Purple Maize
1 Piperine
1 isoflavones
1 α-Santalol/Sandalwood oil
1 Sesamin
1 Shikonin
1 Selenite (Sodium)
1 Ursolic acid
1 Urolithin
1 Zerumbone
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:299  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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