TGF-β Cancer Research Results

TGF-β, transforming growth factor-beta: Click to Expand ⟱
Source: HalifaxProj(inhibit) CGL-CS TCGA
Type:
Human malignancies frequently exhibit mutations in the TGF-β pathway, and overactivation of this system is linked to tumor growth by promoting angiogenesis and inhibiting the innate and adaptive antitumor immune responses.
Anti-inflammatory cytokine.
In normal tissues, TGF-β plays an essential role in cell cycle regulation, immune function, and tissue remodeling.
- In early carcinogenesis, TGF-β typically acts as a tumor suppressor by inhibiting cell proliferation and inducing apoptosis.

In advanced cancers, cells frequently become resistant to the growth-inhibitory effects of TGF-β.
- TGF-β then switches roles and promotes tumor progression by stimulating epithelial-to-mesenchymal transition (EMT), cell invasion, metastasis, and immune evasion.

Non-canonical (Smad-independent) pathways, such as MAPK, PI3K/Akt, and Rho signaling, also contribute to TGF-β-mediated responses.

Elevated levels of TGF-β have been detected in many advanced-stage cancers, including breast, lung, colorectal, pancreatic, and prostate cancers.
 - The switch from a tumor-suppressive to a tumor-promoting role is often associated with increased TGF-β production and activation in the tumor microenvironment.

High TGF-β expression or signaling activity is frequently correlated with aggressive disease features, resistance to therapy, increased metastasis, and poorer overall survival in many cancer types.
Scientific Papers found: Click to Expand⟱
4328- VitB5,    Pantethine
- Review, AD, NA
*BBB↝, *LDL↓, *lipid-P↓, *AST↓, *ALAT↓, *TGF-β↓, *adiP↑, *Inflam↓, TumCG↓, FASN↓,
1223- VitD3,    Vitamin D3 Treatment Influences PGE2 and TGFβ in Normal and Increased Breast Cancer Risk Women
- Trial, NA, NA
*TGF-β↑, *PGE2↓,
2276- VitK2,    Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
- in-vivo, Nor, NA
*Albumin↑, *AST↓, *ALAT↓, *Keap1↓, *NRF2↑, *HO-1↑, *COX2↓, *iNOS↓, *TNF-α↓, *TIMP1↓, *TGF-β↓, *ROS↓, *DNAdam↓, *Inflam↓,

Showing Research Papers: 101 to 103 of 103
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 103

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

FASN↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   Keap1↓, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   ALAT↓, 2,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Migration(tgid=13) ⓘ

TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   Inflam↓, 2,   PGE2↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   Albumin↑, 1,   AST↓, 2,  
Total Targets: 21

Scientific Paper Hit Count for: TGF-β, transforming growth factor-beta
10 Curcumin
6 Magnetic Fields
6 Thymoquinone
5 Artemisinin
5 Ellagic acid
5 Quercetin
3 Apigenin (mainly Parsley)
3 Baicalein
3 Radiotherapy/Radiation
3 EGCG (Epigallocatechin Gallate)
3 Emodin
3 Garcinol
3 Propolis -bee glue
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
3 Shikonin
2 Allicin (mainly Garlic)
2 Ashwagandha(Withaferin A)
2 Berberine
2 Piperine
2 HydroxyTyrosol
2 Magnetic Field Rotating
1 1,8-Cineole
1 3-bromopyruvate
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Andrographis
1 Berbamine
1 Betulinic acid
1 Boron
1 Caffeine
1 Celecoxib
1 Copper and Cu NanoParticles
1 Oxaliplatin
1 Date Fruit Extract
1 D-limonene
1 Gemcitabine (Gemzar)
1 Docetaxel
1 Eurycomanone
1 Fisetin
1 Shilajit/Fulvic Acid
1 Cisplatin
1 Paclitaxel
1 Ginkgo biloba
1 Gossypol
1 Hydroxycinnamic-acid
1 Lactoferrin
1 methotrexate
1 Luteolin
1 Bortezomib
1 Magnolol
1 MCToil
1 Metformin
1 Naringin
1 Phenylbutyrate
1 Rosmarinic acid
1 Selenium
1 Salvia miltiorrhiza
1 doxorubicin
1 Ursolic acid
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:304  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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