| Source: HalifaxProj (block) |
| Type: |
| Tumor Necrosis Factor-alpha (TNF-α) is a cytokine that plays a complex role in cancer biology. It is primarily produced by activated macrophages and is involved in systemic inflammation.
TNF-α is a pro-inflammatory cytokine that can promote inflammation, which is a known factor in cancer development. Overall, the expression of TNF-α in cancers is often linked to inflammation, tumor progression, and the tumor microenvironment. |
| 3854- | CAP, | Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice |
| - | in-vivo, | AD, | NA |
| 5766- | CAPE, | A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model |
| - | in-vivo, | Nor, | NA |
| 5900- | CAR, | TV, | Lights and Shadows of Essential Oil-Derived Compounds: Antimicrobial and Anti-Inflammatory Properties of Eugenol, Thymol, Cinnamaldehyde, and Carvacrol |
| - | Review, | Nor, | NA |
| 5894- | CAR, | Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential |
| - | Review, | Var, | NA |
| 5925- | CAR, | Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review |
| - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | Stroke, | NA |
| 3869- | Carno, | Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation |
| - | Review, | AD, | NA | - | Review, | Stroke, | NA |
| 5922- | Cats, | Uncaria tomentosa acts as a potent TNF-α inhibitor through NF-κB |
| - | in-vitro, | AML, | THP1 |
| 5913- | Cats, | Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection |
| - | Review, | Nor, | NA |
| 5943- | Cela, | Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases |
| - | Review, | Arthritis, | NA | - | Review, | IBD, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 5948- | Cela, | Recent Trends in anti-tumor mechanisms and molecular targets of celastrol |
| 2393- | Cela, | Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect |
| - | in-vivo, | Sepsis, | NA | - | in-vitro, | Nor, | RAW264.7 |
| 2392- | Cela, | The role of natural products targeting macrophage polarization in sepsis-induced lung injury |
| - | Review, | Sepsis, | NA |
| 6018- | CGA, | Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems |
| - | Review, | Var, | NA | - | Review, | RCC, | NA |
| 6017- | CGA, | Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment |
| - | Review, | Var, | NA |
| 6002- | CGA, | Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials |
| - | Review, | Var, | NA | - | Review, | Diabetic, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | Stroke, | NA |
| 6007- | CGA, | A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer |
| - | Review, | CRC, | NA |
| 6010- | CGA, | The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review |
| - | Review, | Nor, | NA |
| 6034- | CGA, | Effect and mechanism of chlorogenic acid on cognitive dysfunction in mice by lipopolysaccharide-induced neuroinflammation |
| - | in-vivo, | AD, | NA |
| 6025- | Chit, | Glycated chitosan as a new non-toxic immunological stimulant |
| - | vitro+vivo, | Var, | HeLa |
| 5988- | Chit, | Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways |
| - | Review, | Var, | NA |
| 6128- | CHr, | Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential |
| - | Review, | Nor, | NA | - | Review, | Var, | NA | - | Review, | AD, | NA |
| 2781- | CHr, | PBG, | Chrysin a promising anticancer agent: recent perspectives |
| - | Review, | Var, | NA |
| 2782- | CHr, | Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives |
| - | Review, | Var, | NA | - | Review, | Stroke, | NA | - | Review, | Park, | NA |
| 2785- | CHr, | Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin |
| - | Review, | Var, | NA |
| 2787- | CHr, | Network pharmacology unveils the intricate molecular landscape of Chrysin in breast cancer therapeutics |
| - | Analysis, | Var, | MCF-7 |
| 2794- | CHr, | An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches |
| - | Review, | Park, | NA | - | Review, | Stroke, | NA |
| 1145- | CHr, | Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways |
| - | in-vitro, | Cerv, | HeLa |
| 4259- | Cin, | The Potential of Cinnamon as Anti-Depressant |
| - | Review, | NA, | NA |
| 6169- | Cin, | Unlocking the Power of Cinnamon: A Detailed Review of Cinnamon Therapeutic Effects in Chronic Disease Management |
| - | Review, | Var, | NA | - | Review, | Diabetic, | NA | - | Review, | AD, | NA | - | Review, | IBD, | NA |
| 1574- | Citrate, | Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Melanoma, | WM983B | - | in-vivo, | NA, | NA |
| 3996- | CoQ10, | Coenzyme Q10 decreases TNF-alpha and IL-2 secretion by human peripheral blood mononuclear cells |
| - | in-vitro, | Nor, | NA |
| 3995- | CoQ10, | Effects of Coenzyme Q10 on TNF-alpha secretion in human and murine monocytic cell lines |
| - | in-vitro, | NA, | NA |
| 3994- | CoQ10, | Se, | Coenzyme Q10 Supplementation in Aging and Disease |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 5780- | CRMs, | HCAs, | RES, | Sper, | ASA | Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential |
| - | Review, | Var, | NA |
| 6309- | Cro, | Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway |
| - | in-vitro, | CRC, | HCT116 |
| 6304- | Cro, | Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ |
| - | in-vitro, | BC, | NA |
| 6301- | Cro, | Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways |
| - | vitro+vivo, | Colon, | HT29 | - | in-vitro, | Colon, | Caco-2 |
| 6300- | Cro, | Interaction of saffron and its constituents with Nrf2 signaling pathway: A review |
| - | Review, | Nor, | NA | - | Review, | Arthritis, | NA |
| - | in-vivo, | Nor, | NA |
| 6294- | Cro, | Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention |
| - | Review, | Var, | NA |
| 3635- | Cro, | A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures |
| - | Review, | NA, | NA |
| 6214- | CUR, | Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve |
| 6215- | CUR, | Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer |
| - | Review, | Var, | NA |
| 6216- | CUR, | Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials |
| - | Review, | Var, | NA |
| 6050- | CUR, | SeNPs, | Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer's disease |
| - | in-vivo, | AD, | NA |
| 2818- | CUR, | Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways |
| - | Review, | AD, | NA |
| 3794- | CUR, | Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities |
| - | Review, | AD, | NA |
| 3795- | CUR, | Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence |
| - | Review, | AD, | NA |
| 3583- | CUR, | Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers |
| - | Review, | Arthritis, | NA |
| 3588- | CUR, | The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies |
| - | Review, | AD, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:309 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid