TumAuto Cancer Research Results

TumAuto, Tumor autophagy: Click to Expand ⟱
Source: HalifaxProj(activate)
Type:
Autophagy genes, including Atg3, Atg5, Atg6, Atg7, Atg10, Atg12, and Atg17.
Tumor autophagy refers to the process by which cancer cells degrade and recycle cellular components through autophagy, a cellular mechanism that helps maintain homeostasis and respond to stress. Autophagy can have dual roles in cancer, acting as both a tumor suppressor and a promoter, depending on the context.
Authophagy is the process used by cancer cells to “self-eat” to survive. Authophagy can be both good and bad. If authophagy is prolonged this will become a lethal process to cancer. On the other hand, for a short while (e.g. during chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive.
For example, Chloroquine is a blocker of autophagy and has been used in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy.
Scientific Papers found: Click to Expand⟱
439- CUR,    Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway
- in-vitro, CRC, LGR5
Apoptosis↑, TumAuto↑, GP1BB↓, COL9A3↓, COMP↓, AGRN↓, ITGB4↓, LAMA5↓, COL2A1↓, ITGB6↓, LGR5↓, TFAP2A↓, ECM/TCF↓,
132- CUR,    Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells
- in-vitro, Pca, PC3
TumCCA↑, ROS↑, TumAuto↑, UPR↑, ER Stress↑, Casp3↑, Casp9↑, Casp12↑, PARP↑, other↝, GRP78/BiP↑, PDI↑, eIF2α↑, other↝,
159- CUR,    Crosstalk from survival to necrotic death coexists in DU-145 cells by curcumin treatment
- in-vitro, Pca, DU145
ROS↑, p‑Jun↑, p‑p38↑, TumAuto↑, Casp8↑, Casp9↑, Akt↓, ERK↓, p38↓,
6221- CUR,    Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer
- Review, Var, NA
NF-kB↓, Imm↑, *TAC↑, *MDA↓, ROS↑, TumAuto↑, TumCCA↑, Keap1↑, ChemoSen↑, ER Stress↑, eff↓, TrxR↓, STAT3↓, *BioAv↓,
2808- CUR,    Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation
- in-vitro, Liver, HUH7
Ferritin↓, IronCh↑, TumAuto↑, Apoptosis↑, eff↝, Dose↝,
6238- CUSP9,    A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3
- Trial, GBM, NA
toxicity↓, TrxR↓, ROS↓, TumCI↓, TumCMig↓, TumCA↓, MMP2↓, MMP9↓, COX2/PTGS2↓, ALDH↓, TumAuto↑, P-gp/ABCB1↓, eff↑,
7444- CYN,    The Sesquiterpene Lactone Cynaropicrin Manifests Strong Cytotoxicity in Glioblastoma Cells U-87 MG by Induction of Oxidative Stress
- in-vitro, GBM, U87MG
TumCG↓, Dose↝, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, TumAuto↑, p‑ERK↓, NF-kB↓, ChemoSen↑, eff↓,
7440- CYN,    Suppression of endoplasmic reticulum stress-dependent autophagy enhances cynaropicrin-induced apoptosis via attenuation of the P62/Keap1/Nrf2 pathways in neuroblastoma
- vitro+vivo, neuroblastoma, NA
AntiTum↑, Apoptosis↑, TumAuto↑, TumCG↓,
7438- CYN,    Cynaropicrin Suppresses Cell Proliferation by Inducing Mitophagy through p38 MAPK-Mediated Mitochondrial ROS Generation in Human Hepatocellular Carcinoma Cells
- in-vitro, HCC, NA
tumCV↓, TumAuto↑, selectivity↑, mt-ROS↑, MMP↓, LC3B↑, Beclin-1/ATG6↓, p62↓, PINK1↑, PARK2↑, eff↓, p‑MAPK↑,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1 / PDPK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2/PTGS2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, Synergy↑, Synergy↑, other↝, RadioS↑, toxicity↓, Dose↝, Synergy↑, Synergy↑, Synergy↑, toxicity↝, eff↓,
1869- DCA,    Dichloroacetate induces autophagy in colorectal cancer cells and tumours
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, Pca, PC3 - in-vitro, CRC, HT-29
LC3II↑, ROS↑, mTOR↓, MCT1↓, NADH:NAD↓, NAD↑, TumAuto↑, lactateProd↓, LDH↑,
4901- DCA,  Sal,    Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
- Review, NSCLC, NA
Glycolysis↓, OXPHOS↑, PDKs↓, ROS↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, RadioS↑, TumAuto↑, mTOR↓, LC3s↓, p62↑, TumCG↓, OS↑, toxicity↝, ChemoSen↑, Synergy↑, Synergy↑, Ferritin↓, CSCs↓, EMT↓, ROS↑, Cyt‑c↑, Casp3↑, ER Stress↑, selectivity↑, Synergy↑, TumCG↓,
2273- dietMet,    Methionine and cystine double deprivation stress suppresses glioma proliferation via inducing ROS/autophagy
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vivo, NA, NA
ROS↑, GSH↓, TumCP↓, TumAuto↑, LC3II↑,
5189- dietMet,    Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine
- Review, Var, NA
OS↑, mTORC1↓, TumAuto↑,
5069- dietSTF,    The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases
- Review, Var, NA
Risk↓, ChemoSen↑, RadioS↑, *Dose↝, *Dose↝, *Dose↝, *LDL↓, *CRP↓, *TNF-α↓, TumAuto↓, GLUT1↓, GLUT2↓, glucose↓, IGF-1↓, Insulin↓, mTOR↓, mTORC1↓, AMPK↑, Warburg↓, OXPHOS↑, ROS↑, DNAdam↑, JAK1↓, STAT↓, TumCP↓, QoL↑,
5070- dietSTF,    A review of fasting effects on the response of cancer to chemotherapy
- Review, Var, NA
chemoP↑, ChemoSen↑, *DNArepair↑, *Apoptosis↓, *CD8+↑, UPR↑, eff↝, TumAuto↑,
5071- dietSTF,    Unraveling the impact of intermittent fasting in cancer prevention, mitigation, and treatment: A narrative review
- Review, Var, NA - Review, AD, NA
Risk↓, TumCMig↓, IGF-1↓, TumAuto↑, Inflam↓, ChemoSen↑, Apoptosis↑, chemoP↑, *glucose↓, *AntiDiabetic↑, *cardioP↑, *LDL↓, *BP↓, *neuroP↑, *cognitive↑, *memory↑, *OS↑, *QoL↑, Imm↑, TumCG↓, ChemoSideEff↓, QoL↑,
8845- DIM,  I3C,    3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways
- Review, Var, NA
*BioAv↝, *BioAv↓, *BioAv↓, *AntiAg↑, *ROS↓, *AntiThr↑, *Stroke↓, *CYP1A1↑, *CYP1A2↑, *GSTs↑, *NQO1↑, AntiTum↑, AntiCan↑, TumAuto↓, Let-7↑, miR-34a↑, TumCMig↓, Apoptosis↑, MMP↓, mtDam↑, ROS↑, TumCCA↑, other↝, PSA↓, Dose↝, MMP2↓, MMP3↓, MMP9↓, EGFR↓, RAS↓, PI3K↓, Akt↓, mTOR↓, CDK4↓, cycD1/CCND1↓, P21↑, MDM2↓, TumCP↓, NF-kB↓, RANKL↓, PUMA↓, Wnt↓, MTA2↓, EZH2↓, AhR↓, PTEN↑, NOTCH1↓, IRAK1↓, p27/CDKN1B↓, CDKN1C/p57↓, CDC25↓, EGFR↓, Zeb1↓, FOXM1↓, SOX4↓, E-cadherin↑, uPA↓, uPAR↓,
6270- DL,    d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, H1299
TumCG↓, Apoptosis↑, TumAuto↑, Dose?,
6328- DRE,    Hydroalcoholic extract of Taraxacum officinale induces apoptosis and autophagy in 4T1 breast cancer cells
- in-vitro, BC, 4T1
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, DNAdam↑, BAX↑, Bax:Bcl2↑, P53↑, Beclin-1/ATG6↑, ATG7↑, Bcl-2↓, NO↓,
6350- DRE,    Tracking Evidences of Dandelion for the Treatment of Cancer: From Chemical Composition, Bioactivity, Signaling Pathways in Cancer Cells to Perspective Study
- Review, Var, NA
AntiCan↑, *Bacteria↓, *Inflam↓, *antiOx↑, TumCCA↑, Apoptosis↑, MOMP↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, MMP↓, Bcl-2↓, TumCMig↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓, TumAuto↑, mTOR↓, 4E-BP1↓, Glycolysis↓, angioG↓,
6319- DRE,    Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells
- in-vitro, AML, MV411 - in-vitro, AML, HL-60
Apoptosis↑, TumAuto↑, *toxicity↓, selectivity↑, Casp8↑, MMP↓, *Inflam↓, *antiOx↑, *AntiCan↑, DNAdam↑, cl‑Casp3↑, tumCV↓, ROS↑,
6320- DRE,    Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
Apoptosis↑, MMP↓, TumAuto↑, selectivity↑, eff↑, Casp8↑, Casp3↑, cl‑BID↑, mtDam↑, ROS↑,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *Synergy↑, *BioAv↑, Synergy↑, ChemoSen↑, *toxicity↝,
643- EGCG,    New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate
- Analysis, Var, NA
H2O2↑, Fenton↑, PDGFR-BB↑, EGFR↓, VEGFR2/KDR/Flk1↓, IGFR↓, Ca+2↑, NO↑, Sp1/3/4↓, NF-kB↓, AP-1↓, STAT1↓, STAT3↓, FOXO↓, mtDam↑, TumAuto↑,
655- EGCG,    A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells
- in-vitro, HCC, HepG2
AFP↓, TumAuto↑, LC3II↑, TumCG↓, MMP↓,
691- EGCG,    Preclinical Pharmacological Activities of Epigallocatechin-3-gallate in Signaling Pathways: An Update on Cancer
- Review, Var, NA
Apoptosis↑, necrosis↑, TumAuto↑, ERK↓, p38↓, NF-kB↓, VEGF↓,
676- EGCG,  Chemo,    The Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review
- Review, Var, NA
PI3k/Akt/mTOR↓, Apoptosis↑, ROS↑, TumAuto↑,
681- EGCG,    Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models
- vitro+vivo, BC, NA
Casp3↑, Casp8↑, Casp9↑, TumAuto↑, Beclin-1/ATG6↝, ATG5↝, GlucoseCon↓, lactateProd↓, ATP↝, HK2↓, LDHA↓, Hif1a↓, GLUT1↓, TumVol↓, VEGF↓,
5931- EGCG,  BTZ,    EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism
- in-vitro, Pca, PC3
TumAuto↑, CHOP/DDIT3↓, TumCD↓, eff↓,
1322- EMD,    The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers
- Review, Var, NA
Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, Synergy↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,
1323- EMD,    Anticancer action of naturally occurring emodin for the controlling of cervical cancer
- Review, Cerv, NA
TumCCA↑, DNAdam↑, mTOR↓, Casp3↑, Casp8↑, Casp9↑, TGF-β↑, SMAD3↓, p‑SMAD4↓, ROS↑, MMP↓, CXCR4↓, HER2/EBBR2↓, ER Stress↓, TumAuto↑, NOTCH1↓,
975- Est,    Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism
- vitro+vivo, UEC, NA
GLS↑, cMyc↑, GlutMet↑, tumCV↑, TumAuto↓,
6390- Eug,    Molecular mechanisms of eugenol as an antitumour bioactive compound: A comprehensive review
- Review, Var, NA
TumCCA↑, angioG↓, TumMeta↓, tumCV↓, Casp3↑, Casp6↑, DFF45↑, PARP↑, ROS↑, Cyt‑c↑, MPT↑, *ROS↓, NF-kB↓, COX2/PTGS2↓, 5LO↓, EMT↓, Snail↓, E-cadherin↑, Vim↓, PI3K↓, Akt↓, mTORC2↓, TumAuto↑, FOXO3↓, Apoptosis↑, ChemoSen↑, RadioS↑, DNMT1↓, DNMT3A↓,
6391- Eug,  BCP,  5-FU,    Exploring Mechanism of Actions for Eugenol and Beta-Caryophyllene to Combat Colorectal Cancer Chemotherapy Using Network Pharmacology
- in-vitro, CRC, HCT116
Synergy↑, ChemoSen↑, HSP90↓, Dose↝, TumAuto↑, Apoptosis↑, PI3K↓, Akt↓, mTOR↓, JNK↓, p38↓, EMT↓,
6386- Eug,    A comprehensive and systematic review on potential anticancer activities of eugenol: From pre-clinical evidence to molecular mechanisms of action
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, Inflam↝, TumCI↓, TumMeta↓, cycD1/CCND1↓, CycB/CCNB1↓, PCNA↓, NF-kB↓, Bcl-2↓, BAX↑, AIF↑, P21↑, P53↑, ChemoSen↑,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *CompStab↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1 / PDPK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6331- Eug,    Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
- in-vitro, BC, MDA-MB-231
Apoptosis↑, TumAuto↑, TumCP↓, Akt↑, FOXO3↑, P21↑, p27/CDKN1B↑, Casp3↑, Casp9↑, LC3s↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, E2Fs↓, survivin↓, BAX↑, Cyt‑c↑,
6848- EVO,    Evodiamine: A Extremely Potential Drug Development Candidate of Alkaloids from Evodia rutaecarpa
- Review, Nor, NA
AntiTum↑, cardioP↑, Inflam↓, TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, BioAv↓, toxicity↑, NF-kB↓, MAPK↓, NOD1↓, p‑Akt↓, BAX↑, cl‑Casp3↑, γH2AX↑, cl‑PARP↑, ROS↑, BBB↑, neuroP↑, BioAv↑,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, Synergy↑, Synergy↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
6910- FIS,    Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer
- in-vitro, Lung, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumCI↓, TumAuto↝, ChemoSen↑, RadioS↑, chemoP↑, BioAv↓, Half-Life↓,
6901- FIS,    Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
- in-vivo, HNSCC, CAL33
TumCG↓, TumCD↑, selectivity↑, TumCCA↑, CDC25↓, CDK1↓, CycB/CCNB1↓, P53↑, DNAdam↑, Apoptosis↑, γH2AX↑, cl‑PARP↑, other↝, JNK↑, PI3K↓, Akt↓, ERK↓, EGFR↓, STAT3↓, TumAuto↑, Dose↝, TumVol↓, Ki-67↓, cl‑Casp3↑, P21↓, p27/CDKN1B↓,
6898- FIS,    Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
mTOR↓, Akt↓, AMPK↑, TumCG↓, mTORC1↓, mTORC2↓, 4E-BP1↑, LC3II↑, TumAuto↑,
6984- Form,    Formononetin suppresses colitis-associated colon cancer by targeting lipid synthesis and mTORC2/Akt signaling
- in-vitro, Colon, HCT116 - Review, IBD, RAW264.7
*Inflam↓, AntiCan↑, *NF-kB↓, *MAPK↓, *colonLen↑, TumCG↓, Apoptosis↑, LC3II↑, Beclin-1/ATG6↑, cl‑Casp3↑, BAX↑, Bcl-2↓, IGF-1↓, ACLY↓, Acetyl-CoA↓, Fas↓, HSL/LIPE↓, ATGL/PNPLA2↓, FFA/NEFA↓, GSK‐3β↑, p‑mTOR↓, Rictor↓, p‑Akt↓, PDE3B↓, p‑PKA↓, p‑HSL/LIPE↑, TumAuto↑,
6972- Form,  PacT,    Formononetin ameliorates the drug resistance of Taxol resistant triple negative breast cancer by inhibiting autophagy
- in-vivo, BC, MDA-MB-231
AntiCan↑, miR-199↓, ChemoSen↑, TumVol↓, Dose↝, TumCG↓, TumCCA↑, Apoptosis↑, TumAuto↓, eff↓,
7041- GA,    Gallic acid suppresses the progression of clear cell renal cell carcinoma through inducing autophagy via the PI3K/Akt/Atg16L1 signaling pathway
- vitro+vivo, RCC, 786-O - in-vitro, RCC, ACHN - in-vitro, Nor, HK-2
selectivity↑, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumVol↓, TumW↓, Ki-67↓, MMP9↓, TumAuto↑, LC3B-II↓, Beclin-1/ATG6↓, p62↑,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
2060- GamB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA
TumCP↓, TumAuto↑, eff↑, ROS↑, ER Stress↑, JNK↑,
1970- GamB,    Gambogic acid-induced autophagy in nonsmall cell lung cancer NCI-H441 cells through a reactive oxygen species pathway
- in-vitro, Lung, NCI-H441
TumCG↓, TumAuto↑, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↑, ROS↑, eff↓,

Showing Research Papers: 101 to 150 of 320
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 320

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   ARE↓, 1,   Catalase↓, 4,   Catalase↑, 5,   DJ-1↓, 1,   Fenton↑, 3,   GPx↓, 1,   GPx4↓, 10,   GPx4↑, 1,   GSH↓, 14,   GSH↑, 2,   GSH/GSSG↓, 1,   GSR↑, 1,   GSTs↑, 2,   H2O2↑, 8,   HNE↑, 1,   HO-1↓, 6,   HO-1↑, 3,   Iron↑, 9,   i-Iron↓, 1,   i-Iron↑, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 2,   lipid-P↑, 7,   MDA↓, 2,   MDA↑, 5,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 9,   NRF2↑, 4,   NRF2↝, 1,   Prx↓, 2,   PrxI↓, 1,   PrxII↓, 1,   ROS↓, 14,   ROS↑, 169,   ROS⇅, 2,   ROS↝, 2,   i-ROS↑, 1,   m-ROS↑, 1,   mt-ROS↑, 4,   SOD?, 1,   SOD↓, 3,   SOD↑, 2,   mt-SOD↑, 1,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   TKT↓, 1,   TrxR↓, 2,   TrxR1↓, 3,   xCT/SLC7A11↓, 4,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 6,   FTH1↓, 1,   IronCh↑, 1,   NCOA4↑, 1,   SFXN2↓, 1,   Tf↓, 1,   Tf↑, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 4,   CDC25↓, 8,   compI↓, 4,   compIII↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   Insulin↓, 1,   mitResp↓, 2,   mitResp↑, 1,   Mortalin↓, 1,   mtDam↑, 27,   OCR↓, 6,   OCR↑, 1,   OXPHOS↓, 6,   OXPHOS↑, 5,   OXPHOS↝, 1,   mt-OXPHOS↓, 1,   PDH↓, 2,   PDH↝, 1,   PINK1↑, 5,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   AApath↓, 1,   ACC↓, 1,   ACC-α↓, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 4,   ACSL4↑, 1,   ALAT↓, 2,   ALDOA↓, 1,   AMP↓, 1,   AMP↑, 1,   AMPK↑, 26,   p‑AMPK↑, 2,   ATGL/PNPLA2↓, 1,   ATP↓, 26,   ATP↝, 1,   CRM↑, 2,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 2,   FFA/NEFA↓, 1,   GAPDH↓, 1,   GLS↑, 1,   glucose↓, 2,   GlucoseCon↓, 4,   GlucoseCon↑, 1,   GlutMet↑, 1,   Glycolysis↓, 25,   Glycolysis↑, 1,   Glycolysis↝, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   Histones↝, 1,   HK1↓, 1,   HK2↓, 15,   HK2↑, 1,   HMG-CoA↓, 3,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 12,   lactateProd↑, 1,   LDHA↓, 4,   LDHA↑, 1,   LDL↓, 1,   lipoGen↓, 2,   MCT4↓, 1,   NAD↑, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 3,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PFK↓, 1,   PFKP↓, 1,   PKM2↓, 10,   PKM2↑, 1,   PLA2↓, 1,   p‑S6↓, 1,   SCP2↓, 1,   SIRT1↓, 5,   SIRT1↑, 4,   SREBP1/SREBF1↓, 2,   TCA↓, 2,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 4,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 183,   mt-Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 1,   BAD↑, 5,   Bak↑, 1,   BAX↓, 1,   BAX↑, 50,   Bax:Bcl2↑, 15,   Bcl-2↓, 57,   Bcl-2↑, 1,   Bcl-xL↓, 12,   Bcl-xL↑, 2,   BID↑, 2,   cl‑BID↑, 1,   BIM↑, 2,   BNIP3?, 1,   BNIP3↝, 2,   Casp↑, 16,   cl‑Casp↑, 1,   Casp1↓, 2,   proCasp1↓, 1,   Casp12↑, 2,   Casp3↓, 2,   Casp3↑, 62,   cl‑Casp3↑, 29,   proCasp3↓, 1,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp6↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 1,   Casp8↑, 14,   cl‑Casp8↑, 2,   proCasp8↑, 2,   Casp9↑, 33,   cl‑Casp9↑, 7,   proCasp9↑, 1,   CellShr↑, 1,   cFLIP↓, 3,   Cyt‑c↑, 41,   DR5↑, 9,   Endon↑, 1,   FADD↑, 3,   Fap1↓, 1,   Fas?, 1,   Fas↓, 2,   Fas↑, 13,   FasL↑, 8,   Ferroptosis↓, 1,   Ferroptosis↑, 20,   GRP58↓, 1,   IAP1↓, 4,   ICD↑, 2,   iNOS↓, 5,   iNOS↑, 1,   Mcl-1↓, 4,   MDM2↓, 8,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↑, 5,   Necroptosis↑, 4,   necrosis↑, 8,   NOXA↑, 1,   oncosis↑, 2,   P2X7↓, 1,   p38↓, 4,   p38↑, 11,   p‑p38↑, 3,   Paraptosis↑, 2,   PUMA↓, 1,   PUMA↑, 2,   Pyro↑, 2,   RIP3↓, 1,   RIP3↑, 2,   p‑RIP3↑, 2,   survivin↓, 20,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAIL⇅, 1,   TRAILR↑, 2,   TumCD↓, 1,   TumCD↑, 18,   XIAP↓, 7,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 87,   Akt↑, 4,   p‑Akt↓, 21,   p‑Akt↑, 1,   AKT1↓, 3,   AMPKα↑, 3,   BCAP↓, 1,   CaMKII ↓, 1,   Cavin3↓, 1,   CIP2A↓, 2,   cMET↓, 1,   p‑cMET↑, 1,   EGFR↓, 13,   ERK↓, 17,   ERK↑, 3,   ERK↝, 2,   p‑ERK↓, 6,   p‑ERK↑, 3,   FOXD3↑, 1,   GNAI1↓, 1,   HER2/EBBR2↓, 6,   Hippo↓, 1,   IGFR↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB↑, 1,   JAK↓, 2,   JAK1↓, 2,   JAK2↓, 2,   JAK3↓, 1,   JNK↓, 3,   JNK↑, 18,   p‑JNK↑, 2,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 14,   MAPK↑, 11,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 3,   MEK↑, 1,   MKK4↓, 1,   mTOR↓, 75,   mTOR↑, 7,   mTOR∅, 1,   p‑mTOR↓, 13,   p‑mTOR↑, 1,   mTORC2↓, 2,   p‑p70S6↓, 2,   P70S6K↓, 6,   P70S6K↑, 1,   p‑P70S6K↓, 1,   p‑P70S6K↑, 1,   PDE3B↓, 1,   PDGFR-BB↑, 1,   PDGFRB↓, 1,   PI3K↓, 64,   PI3K↑, 1,   p‑PI3K↓, 3,   PI3k/Akt/mTOR↓, 2,   PIK3CA↑, 1,   p‑PIK3R1↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 3,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 7,   Raf↓, 1,   RAS↓, 5,   Rictor↓, 1,   RIP1↓, 2,   SHP1↑, 1,   Sp1/3/4↓, 7,   Src↓, 1,   STAT↓, 2,   STAT3↓, 19,   STAT3↑, 3,   STAT3↝, 2,   p‑STAT3↓, 1,   STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 7,   cJun↓, 1,   cJun↑, 2,   cMyc↓, 10,   cMyc↑, 2,   p‑cMyc↑, 1,   COMP↓, 1,   CREBBP↓, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 1,   EZH2↓, 2,   FOXM1↓, 1,   FOXO↓, 1,   FOXO1↓, 1,   FOXO1↑, 3,   FOXO3↓, 2,   FOXO3↑, 3,   FOXO3↝, 1,   FOXO4↑, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 8,   HDAC∅, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 2,   HES1↓, 1,   HMTs↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-140↑, 1,   miR-155↓, 1,   miR-182-5p↓, 1,   miR-199↓, 1,   miR-200c↑, 1,   miR-21↓, 4,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-29b↓, 1,   miR-340↓, 1,   miR-34a↑, 2,   miR-375↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   miR-486↑, 1,   miR-592↑, 1,   MTA2↓, 1,   Myc↓, 2,   OCT4↓, 4,   other?, 1,   other↓, 5,   other↑, 4,   other↝, 17,   SOX2↓, 1,   SOX4↓, 2,   SUV39H↓, 1,   TFAP2A↓, 1,   TFE3↑, 2,   tumCV?, 1,   tumCV↓, 41,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 19,   CHOP/DDIT3↝, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 6,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 50,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 9,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 10,   HSP90↑, 1,   HSPs↑, 1,   IRE1↓, 1,   IRE1↑, 2,   p‑IRE1↑, 1,   PDI↑, 2,   PERK↑, 7,   Proteasome↓, 1,   UPR↑, 6,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

APA↑, 1,   ATG13↑, 2,   ATG16L1↑, 1,   ATG3↑, 5,   ATG5↑, 17,   ATG5↝, 1,   ATG7↑, 7,   autoF↓, 2,   autolysosome↑, 1,   AVOs↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 49,   Beclin-1/ATG6↝, 1,   p‑Beclin-1/ATG6↑, 2,   CTSB↓, 2,   CTSD↓, 1,   CTSL↓, 1,   CTSL↑, 1,   CTSS↓, 1,   CTSZ↓, 1,   LAMP1?, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 14,   LC3A↑, 1,   LC3B↑, 5,   LC3B-II↓, 1,   LC3B-II↑, 11,   LC3I↓, 1,   LC3I↑, 2,   LC3II↑, 41,   LC3s↓, 1,   LC3s↑, 3,   LC3s↝, 1,   lysoM↓, 1,   LysoPr↑, 1,   lysosome↓, 3,   MitoP↑, 3,   p62↓, 28,   p62↑, 11,   PARK2↑, 4,   RUBCN↓, 1,   TFEB↑, 1,   TumAuto?, 1,   TumAuto↓, 16,   TumAuto↑, 299,   TumAuto⇅, 2,   TumAuto↝, 3,   mt-TumAuto↑, 2,   ULK1/ATG1↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↝, 1,   DFF45↑, 1,   DNAdam↑, 31,   DNAdam⇅, 1,   DNArepair↓, 1,   DNArepair↑, 1,   ERCC3↑, 1,   m-FAM72A↓, 1,   HR↓, 1,   hTERT/TERT↓, 4,   p16↑, 2,   P53↓, 3,   P53↑, 45,   p‑P53↑, 4,   PARP↓, 1,   PARP↑, 10,   p‑PARP↑, 1,   cl‑PARP↑, 34,   cl‑PARP↝, 1,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 5,   RAD51↓, 1,   Telomerase↓, 4,   TP53↓, 1,   TP53↑, 1,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↑, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 5,   CDK1↑, 1,   CDK2↓, 6,   CDK2↑, 2,   CDK4↓, 6,   CDK4↑, 1,   CDK4/6↓, 1,   CDK6↓, 4,   CDK6↑, 1,   CDK7↓, 1,   CDKN1C/p57↓, 1,   p‑CHK1↑, 2,   p‑Chk2↑, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 9,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 18,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 4,   cycE1↓, 1,   E2Fs↓, 2,   Ki-67↓, 11,   MAD↓, 1,   mitA↓, 1,   mitA↑, 1,   P21↓, 2,   P21↑, 21,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 8,   RB1↑, 1,   TumCCA↓, 3,   TumCCA↑, 96,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   4E-BP1↑, 1,   p‑4E-BP1↓, 3,   ALDH↓, 2,   ALDH1A1↓, 1,   BMI1↓, 3,   BMP2↓, 1,   BMP7/OP1↓, 1,   CD133↓, 2,   CD24↓, 1,   cFos↓, 1,   cMYB↓, 1,   CSCs↓, 24,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 2,   EIF4E↓, 1,   Gli1↓, 2,   HH↓, 5,   HMGCR↓, 2,   IGF-1↓, 3,   JAG1↓, 1,   p‑Jun↑, 1,   Ki-67↓, 11,   Let-7↑, 1,   LGR5↓, 1,   mTORC1↓, 9,   Nanog↓, 4,   NICD↓, 1,   NOTCH↓, 6,   NOTCH↑, 1,   NOTCH1↓, 6,   NOTCH1↑, 1,   NOTCH3↓, 1,   Piezo1↑, 1,   PTCH1↓, 1,   Shh↓, 2,   Smo↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 60,   TumCG↑, 1,   TumCG⇅, 1,   TumCP?, 1,   TumCP↓, 106,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt↓, 23,   Wnt/(β-catenin)↓, 4,   Wnt/(β-catenin)↑, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AGRN↓, 1,   annexin II↓, 1,   AP-1↓, 2,   AP-1↑, 1,   ASAP2↓, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 19,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 1,   Chl↑, 1,   COL1↓, 2,   COL2A1↓, 1,   COL4A3↓, 1,   COL9A3↓, 1,   E-cadherin↑, 14,   EMT↓, 30,   EMT↑, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 5,   FAK↑, 1,   Fibronectin↓, 1,   GLI2↓, 1,   GP1BB↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 1,   ITGB6↓, 2,   LAMA5↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP15↓, 1,   MMP16↓, 1,   MMP2↓, 27,   MMP3↓, 5,   MMP9↓, 34,   MMP9:TIMP1↓, 1,   MMPs↓, 7,   MTA1↓, 1,   N-cadherin↓, 7,   NCAM↑, 1,   PAK1↓, 3,   PAK1↑, 1,   RECK↑, 1,   Rho↓, 1,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 4,   Smad1↓, 1,   SMAD3↓, 1,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 9,   STAC2↓, 1,   TET1↑, 2,   TGF-β↓, 6,   TGF-β↑, 2,   TIMP1↓, 1,   TIMP1↑, 5,   TIMP2↓, 3,   TIMP2↑, 4,   TSC1↑, 1,   TumCA↓, 2,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 49,   TumCMig↓, 42,   TumMeta↓, 37,   TumMeta↑, 1,   Twist↓, 3,   uPA↓, 6,   uPAR↓, 1,   Vim↓, 14,   Zeb1↓, 3,   ZEB2↓, 1,   α-SMA↓, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 19,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 50,   angioG↑, 2,   CD31/PECAM-1↓, 2,   ECM/TCF↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 1,   HIF-1↓, 3,   Hif1a↓, 21,   Hif1a↑, 2,   NO↓, 2,   NO↑, 3,   TYMP/ECGF1↓, 1,   VCAM-1↓, 1,   VEGF↓, 30,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   BBB∅, 1,   CLDN1↓, 1,   CX43/GJA1↓, 1,   EPR↑, 2,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 72,   MMP↑, 1,   MPT↑, 5,   TRPM7↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 6,   CD59↑, 1,   COX2/PTGS2↓, 25,   COX2/PTGS2↑, 1,   CXCL6/GCP-2↓, 1,   CXCR4↓, 3,   DR4↑, 4,   FOXP3↑, 2,   Gal1↑, 1,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   Igs↑, 1,   IL1↓, 4,   IL10↓, 3,   IL17↓, 1,   IL1β↓, 6,   IL1β↑, 1,   IL2↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 13,   IL8↓, 3,   Imm↑, 14,   Imm↝, 3,   Inflam↓, 20,   Inflam↝, 1,   IRAK1↓, 1,   LRIG1↑, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 3,   MCT1↓, 1,   MIP2↓, 1,   MyD88↑, 1,   NAF1↓, 1,   NF-kB↓, 51,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 2,   NLRP3↑, 2,   NOD1↓, 1,   p65↓, 1,   PD-1↓, 1,   PD-L1↓, 4,   PGE2↓, 7,   PSA↓, 1,   RAGE↓, 2,   T-Cell↑, 1,   TCF↓, 1,   TCF↝, 1,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 5,   TLR4↑, 1,   TNF-α↓, 11,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   e-pH↑, 2,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AR↓, 4,   CYP19↓, 1,   ER-α36↓, 1,   Estro↝, 1,   PPARγ↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 2,   BioAv↓, 22,   BioAv↑, 19,   BioAv↝, 5,   BioEnh↑, 2,   CBR1↓, 1,   ChemoSen↓, 4,   ChemoSen↑, 77,   CompStab?, 1,   CompStab↓, 1,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 32,   Dose∅, 7,   eff↓, 46,   eff↑, 57,   eff↝, 5,   eff∅, 1,   GSTZ1↓, 1,   Half-Life↓, 6,   Half-Life↝, 3,   MDR1↓, 7,   P-gp/ABCB1↓, 12,   P-gp/ABCB1↝, 1,   P450↓, 1,   RadioS↑, 27,   selectivity↓, 1,   selectivity↑, 37,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 57,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 4,   AST↓, 2,   BRCA1↓, 1,   BRCA1↝, 1,   CA19-9↓, 1,   CEA↓, 1,   EGFR↓, 13,   EZH2↓, 2,   Ferritin↓, 6,   FOXM1↓, 1,   HER2/EBBR2↓, 6,   hTERT/TERT↓, 4,   IL6↓, 13,   LDH↓, 8,   LDH↑, 2,   p‑LDH↓, 1,   Myc↓, 2,   PD-L1↓, 4,   PSA↓, 1,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 33,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↑, 14,   cachexia↓, 1,   cardioP↑, 4,   CardioT↑, 1,   chemoP↑, 11,   chemoPv↑, 8,   ChemoSideEff↓, 4,   cognitive↑, 1,   fatigue↓, 2,   hepatoP↓, 1,   hepatoP↑, 1,   hepatoP∅, 1,   Mucositis↓, 1,   neuroP↑, 2,   OS↑, 9,   OS∅, 1,   PFS∅, 1,   QoL↑, 4,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 3,   Risk↓, 9,   Sleep↑, 1,   toxicity↓, 15,   toxicity↑, 3,   toxicity↝, 9,   toxicity∅, 3,   TumVol↓, 21,   TumW↓, 13,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 1,   Bacteria↓, 2,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 7,  
Total Targets: 896

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 27,   ARE↑, 1,   Catalase↑, 9,   GPx↑, 7,   GPx1↑, 2,   GPx4↑, 2,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 3,   HO-1?, 1,   HO-1↑, 4,   i-Iron↓, 1,   lipid-P↓, 8,   MDA↓, 5,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 11,   ROS↓, 29,   ROS↑, 1,   SOD↑, 10,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↑, 1,   mtDam↓, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 1,   glucose↓, 2,   glucose↝, 1,   H2S↑, 1,   LDL↓, 3,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 2,   Casp3↓, 4,   Casp9↓, 2,   Cyt‑c↓, 1,   Ferroptosis↓, 1,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↑, 1,   CREB↑, 1,   MAPK↓, 3,   mTOR↓, 1,   mTOR↑, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 1,   PI3K↑, 2,   STAT↓, 1,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   HOTAIR↑, 1,   other↑, 2,   other↝, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNArepair↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Cartilage↑, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↑, 1,   MUC5AC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 5,   CXCR4↓, 1,   IL10↓, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL6↓, 8,   IL8↓, 2,   Imm↑, 2,   Imm↝, 1,   Inflam↓, 31,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 10,   NF-kB↑, 1,   NLRP3↓, 3,   NLRP3↑, 2,   PGE2↓, 2,   TNF-α↓, 10,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 4,   GABA↑, 1,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 14,   BioAv↑, 10,   BioAv↝, 5,   CompStab↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   Dose⇅, 2,   Dose↝, 10,   eff↑, 1,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 2,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BloodF↑, 1,   BP↓, 1,   BUN↓, 1,   colonLen↑, 1,   creat↓, 1,   CRP↓, 2,   IL6↓, 8,   LDH↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 2,   AntiArt↑, 4,   AntiCan↓, 1,   AntiCan↑, 9,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 8,   AntiTum↑, 4,   cardioP↑, 17,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 6,   cough?, 1,   hepatoP↑, 11,   memory↑, 4,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 21,   Obesity↓, 2,   OS↑, 1,   Pain↓, 1,   QoL↑, 1,   RenoP↑, 4,   Risk↓, 1,   SoreThr?, 1,   Stroke↓, 6,   Stroke↝, 1,   toxicity?, 1,   toxicity↓, 11,   toxicity↑, 2,   toxicity↝, 11,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiP↑, 6,   AntiViral↑, 6,   Bacteria↓, 8,   Diar↓, 1,   GutMicro↑, 4,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 178

Scientific Paper Hit Count for: TumAuto, Tumor autophagy
15 Curcumin
13 Silver-NanoParticles
11 Artemisinin
9 salinomycin
7 Apigenin (mainly Parsley)
7 EGCG (Epigallocatechin Gallate)
7 Gambogic Acid
7 Ivermectin
6 Magnetic Fields
6 Baicalein
6 Kaempferol
5 Celastrol
5 Eugenol
5 Spermidine
5 itraconazole
5 Licochalcone A
5 Luteolin
5 Matrine
5 Melatonin
5 Shikonin
5 Selenite (Sodium)
4 Radiotherapy/Radiation
4 Allicin (mainly Garlic)
4 Berberine
4 Capsaicin
4 Dandelion Root
4 hydroxychloroquine
4 Ginkgetin
4 Hyperoside
4 Juglone
4 Phenethyl isothiocyanate
4 Urolithin
4 Vitamin K2
3 Astragalus
3 Atorvastatin
3 Betulinic acid
3 Cynaropicrin
3 Dichloroacetate
3 diet Short Term Fasting
3 Fisetin
3 Hibiscus sabdariffa
3 Isoliquiritigenin
3 Sulforaphane (mainly Broccoli)
3 Isovitexin
3 Licorice
3 Quercetin
2 2-DeoxyGlucose
2 3-bromopyruvate
2 Photodynamic Therapy
2 Metformin
2 Ashwagandha(Withaferin A)
2 Boron
2 Centella asiatica / Gotu kola → asiaticoside
2 Chrysin
2 Cranberry
2 Resveratrol
2 diet Methionine-Restricted Diet
2 Chemotherapy
2 Emodin
2 Formononetin
2 Paclitaxel/Taxol
2 Cisplatin
2 Gossypol/AT-101
2 Graviola
2 HydroxyCitric Acid
2 Honokiol
2 isoquercitrin
2 Methyl Jasmonate
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Phenylbutyrate
2 Propolis -bee glue
2 Phycocyanin
2 Psoralidin
2 Silymarin (Milk Thistle) silibinin
2 Ursolic acid
1 cetuximab
1 5-Aminolevulinic acid
1 entinostat
1 wortmannin
1 Allyl isothiocyanate
1 Alpha-Lipoic-Acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Bufalin/Huachansu
1 Benzyl isothiocyanate
1 borneol
1 Beetroot
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Celecoxib
1 chaetocin
1 chitosan
1 Citric Acid
1 Coenzyme Q10
1 Copper and Cu NanoParticles
1 Cucurbitacin
1 CUSP9
1 Diindolylmethane
1 Indole-3-carbinol
1 D-limonene
1 Ellagic acid
1 Bortezomib
1 Estrogen
1 Beta-Caryophyllene
1 5-fluorouracil
1 Evodiamine
1 Ferulic acid
1 Gallic acid
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Hydrogen Gas
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 Gemcitabine (Gemzar)
1 Helleborus niger extracts – Christmas Rose
1 Isobavachalcone
1 isoorientin
1 Isothiocyanates
1 Vitexin
1 Magnolol
1 mebendazole
1 immunotherapy
1 Magnetic Field Rotating
1 Magnesium
1 Morin
1 doxorubicin
1 Mushroom Chaga, Inonotus obliquus
1 Myricetin
1 Bicarbonate(Sodium)
1 Naringin
1 Patchouli Oil (Pogostemon cablin)
1 Propyl gallate
1 Piperine
1 Plumbagin
1 Parthenolide
1 Pterostilbene
1 α-Santalol/Sandalwood oil
1 Sesamin
1 Spirulina(Arthrospira/Limnospira)
1 VitK3,menadione
1 Vitamin C (Ascorbic Acid)
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:321  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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