β-catenin/ZEB1 Cancer Research Results

β-catenin/ZEB1, β-catenin/ZEB1: Click to Expand ⟱
Source: HalifaxProj (inactivate)
Type:
β-catenin and ZEB1 are two important proteins that play significant roles in cancer biology, particularly in the processes of cell adhesion, epithelial-mesenchymal transition (EMT), and tumor progression.
β-catenin is a key component of the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and survival. It also plays a role in cell-cell adhesion by linking cadherins to the actin cytoskeleton.
Role in Cancer: ZEB1 is often upregulated in cancer and is associated with increased invasiveness and metastasis. It can repress epithelial markers (like E-cadherin) and promote mesenchymal markers (like N-cadherin and vimentin), facilitating the transition to a more aggressive cancer phenotype.

(MMP)-2 and MMP-9, which are the down-stream targets of β-catenin and play a crucial role in cancer cell metastasis.
Scientific Papers found: Click to Expand⟱
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, Synergy↑, ChemoSen↑,
2830- FIS,    Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
- Review, Var, NA
TumCG↓, angioG↓, *ROS↓, TumCMig↓, VEGF↓, MAPK↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, NRF2↑, HO-1↑, ROS↓, Inflam↓, ER Stress↑, ROS↑, TumCP↓, ChemoSen↑, PTEN↑, P53↑, Casp3↑, Casp8↑, Casp9↑, COX2/PTGS2↓, Wnt↓, EGFR↓, Mcl-1↓, survivin↓, IAP1↓, IAP2/BIRC3↓, PGE2↓, β-catenin/ZEB1↓, DR5↑, MMP2↓, MMP9↓, FAK↓, uPA↓, EMT↓, ERK↓, JNK↑, p38↑, PKCδ↓, BioAv↓, BioAv↑, BioAv↑,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, Synergy↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, Synergy↑,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
1113- FIS,    Fisetin suppresses migration, invasion and stem-cell-like phenotype of human non-small cell lung carcinoma cells via attenuation of epithelial to mesenchymal transition
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, Vim↓, N-cadherin↓, MMP2↓, CD44↓, CD133↓, β-catenin/ZEB1↓, NF-kB↓, EGFR↓, STAT3↓, CSCs↓,
2313- Flav,    Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism
- Review, Var, NA
Warburg↓, antiOx↑, angioG↓, Glycolysis↓, PKM2↓, PKM2:PKM1↓, β-catenin/ZEB1↓, cMyc↓, HK2↓, Akt↓, mTOR↓, GLUT1↓, Hif1a↓,
7010- Fuc,    Fucoidan enhances the effect of chemotherapeutic drug against drug-resistant lung cancer cells
- in-vitro, Lung, NA
ChemoSen↑, MMP9↓, Apoptosis↑, LC3s↓, Beclin-1/ATG6↓, β-catenin/ZEB1↓, TumCP↓, TumCMig↓, TumMeta↓,
7087- GAR,    Garcinol as an Epigenetic Modulator: Mechanisms of Anti-Cancer Activity and Therapeutic Potential
- Review, Var, NA
HATs↓, p300↓, CBP↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, Inflam↓, angioG↓, TumCP↓, TumMeta↓, TumCCA↑, EMT↓, CSCs↓, P53↑, TrxR↓, ROS↑, JNK↑, DNAdam↑, mt-Apoptosis↑, ER Stress↑, CHOP/DDIT3↑, DDIT4↑, TRIB3↑, SESN2↑, miR-218↑, eff↑, ChemoSen↑, BioAv↓, Half-Life↓, BioAv↑,
7084- GAR,    A unique in vivo pharmacokinetic profile, in vitro metabolic stability and hepatic first-pass metabolism of garcinol, a promising novel anticancer phytoconstituent, by liquid chromatography–mass spectrometry
- in-vivo, Nor, NA
*BioAv↝, *Dose↝, *Inflam↓, *antiOx↑, *chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ERK↓, PI3K↓, Akt↓, NF-kB↓, STAT3↓, TumCP↓, antiNeop↑, ChemoSen↑, chemoP↑,
7092- GAR,    Garcinol and Its Role in Chronic Diseases
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, antiNeop↑, 5LO↓, Synergy↑, HATs↓, p300↓, PCAF↓, miR-200c↑, NOTCH1↓, CSCs↓, COX2/PTGS2↓, cycD1/CCND1↓, VEGF↓, PI3K↓, Akt↓, Wnt↑, β-catenin/ZEB1↓, ROS↑, CHOP/DDIT3↑, Bax:Bcl2↑, Casp8↑, FAK↓, *neuroP↑, PCNA↓, *GSTs↑,
800- GAR,    Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
EMT↓, MET↑, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↑, miR-200c↑, Let-7↑, p‑β-catenin/ZEB1↓, NF-kB↓,
7243- Gink,    Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathwa
- vitro+vivo, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumMeta↓, Akt↓, GSK‐3β↓, Snail↓, Wnt↓, β-catenin/ZEB1↓, *toxicity↓,
7246- Gink,    Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma
- in-vitro, GC, DAOY - in-vitro, MB, D283
Wnt↓, tumCV↓, TumCCA↑, Axin2↓, cycD1/CCND1↓, survivin↓, β-catenin/ZEB1↓,
7254- Gink,    Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumMeta↓, Akt↓, GSK‐3β↓, Snail↓, Wnt↓, β-catenin/ZEB1↓, tumCV↓, Dose↝, N-cadherin↓, Vim↓, EMT↓,
7327- GSE,    Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats
- in-vivo, CRC, NA
chemoPv↑, TumCP↓, Apoptosis↑, cycD1/CCND1↓, COX2/PTGS2↓, iNOS↓, survivin↓, β-catenin/ZEB1↓, NF-kB↓, Risk↓,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,
2506- H2,    Molecular hydrogen suppresses activated Wnt/β-catenin signaling
- in-vivo, Arthritis, NA
*Wnt↓, *β-catenin/ZEB1↓, *Dose↝,
2877- HNK,    Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer
- in-vitro, GC, AGS
HDAC3↓, NF-kB↓, CEBPB↓, ER Stress↑, EMT↓, Wnt↓, β-catenin/ZEB1↓,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
1087- HNK,    Honokiol Inhibits Non-Small Cell Lung Cancer Cell Migration by Targeting PGE2-Mediated Activation of β-Catenin Signaling
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, Lung, H226
TumCMig↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, p65↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓,
4688- HNK,    Honokiol Suppresses Renal Cancer Cells’ Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling
- vitro+vivo, RCC, A498
CSCs↓, EMT↓, TumCG↓, PI3K↓, Akt↓, mTOR↓, p‑Akt↓, PTEN↑, Wnt↓, β-catenin/ZEB1↓,
4659- HNK,    Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/β-Catenin Signaling and Apoptosis Induction
- in-vitro, Oral, NA
cl‑Casp3↑, survivin↓, Bcl-2↓, CD44↓, Wnt↓, β-catenin/ZEB1↑, EMT↓, Slug↓, Snail↓, CSCs↓, Apoptosis↑,
4636- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/ß-catenin and TGFß signaling
- in-vitro, BC, SUM159 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, BC, BT549
Wnt↓, β-catenin/ZEB1↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, TGF-β↓, CSCs↓, TumCMig↓, chemoP↑,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
4632- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, SUM159
CSCs↓, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, Wnt↓, p‑LRP6↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, SMAD2↓, SMAD3↓, TGF-β↓,
7582- I3C,    Indole-3-Carbinol Promotes Apoptosis and Inhibits the Metastasis of Esophageal Squamous Cell Carcinoma by Downregulating the Wnt/β-Catenin Signaling Pathway
- vitro+vivo, ESCC, NA
Apoptosis↑, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓,
1278- I3C,    Indole-3-carbinol inhibits prostate cancer cell migration via degradation of beta-catenin
- in-vivo, Pca, DU145
TumCMig↓, β-catenin/ZEB1↓,
7774- IBC,    Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
TumCP↓, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, BAX↑, XIAP↓, survivin↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, GSK‐3β↓,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, Synergy↑,
7701- IP6,    Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway
- vitro+vivo, HCC, Hep3B - NA, NA, MHCC-97H
AntiCan↑, ChemoSen↑, LRP6↓, Wnt↓, β-catenin/ZEB1↓, CCN2/CTGF↓, ABCG1↓, TumCP↓, TumCMig↓,
1088- IP6,    Preventive Inositol Hexaphosphate Extracted from Rice Bran Inhibits Colorectal Cancer through Involvement of Wnt/β-Catenin and COX-2 Pathways
- in-vivo, CRC, NA
AntiTum↑, β-catenin/ZEB1↓, COX2/PTGS2↓,
7787- ISL,    Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling
- in-vitro, BC, NA
β-catenin/ZEB1↓, ChemoSen↑, CSCs↓, ABCG2↓, Proteasome↓, GRP78/BiP↓, selectivity↑,
7858- isoO,    Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis
- in-vitro, Oral, SCC25
CSCs↓, EMT↓, JAK↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, TCF7/TCF1↓, LEF1↓, ChemoSen↑,
7853- isoO,    Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review
- Review, Var, NA
Apoptosis↑, TumCCA↑, MAPK?, PI3K↓, Akt↓, AMPK?, NF-kB?, Wnt↓, β-catenin/ZEB1↓, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, Casp↑, TumCP↓, TumMeta↓,
7796- ISQ,    Isoquercitrin restrains the proliferation and promotes apoptosis of human osteosarcoma cells by inhibiting the Wnt/β-catenin pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
TumCP↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, Apoptosis↑, TumMeta↓, TumCCA↑, BAX↑, cl‑Casp3↑, Bcl-2↓,
7792- ISQ,    Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/β-catenin signaling pathway
- in-vitro, CRC, SW48 - in-vitro, CRC, DLD1 - in-vitro, CRC, HCT116 - in-vitro, Nor, IEC-18
Wnt↓, TumCG↓, selectivity↑, β-catenin/ZEB1↓, TumCMig↓,
7840- ISQ,    Neuroprotective effects of isoquercitrin in diabetic neuropathy via Wnt/β-catenin signaling pathway inhibition
- in-vivo, Diabetic, NA
*Pain↓, *Wnt↓, *β-catenin/ZEB1↓, *neuroP↑,
7848- ISQ,    Review of anticancer mechanisms of isoquercitin
- Review, Var, NA
BioAv↑, eff↑, *antiOx↓, TumCP↓, *Inflam↓, *AntiDiabetic↑, lipid-P↓, *toxicity↓, *Half-Life↝, *Half-Life↑, *XO↝, *IronCh↝, *VitC↑, *ROS↓, β-catenin/ZEB1↓, Casp3↑, Casp8↑, Casp9↑, MMP↓, p‑ERK↓, p‑cJun↑,
8001- itraC,    Repurposing itraconazole as an anticancer agent
- Review, Var, NA
*AntiFungal↑, AntiCan↑, P-gp/ABCB1↓, HH↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, angioG↓, LymphAG↓, ChemoSen↑, OS↑, Gli1↓, Ki-67↓, CSCs↓,
8009- itraC,    Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways
- vitro+vivo, Melanoma, SK-MEL-28 - vitro+vivo, Melanoma, A375
OS↑, TumCP↓, Ki-67↓, TumCP↓, Gli1↓, GLI2↓, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, AXIN1↑, GLI3↑, AXIN1↑, HH↓, PI3K↓, Akt↓, *toxicity↓,
8037- IVM,    Ivermectin inhibits tumor metastasis by regulating the Wnt/β-catenin/integrin β1/FAK signaling pathway
- in-vitro, Var, NA
Wnt↓, β-catenin/ZEB1↓, ITGB1↓, FAK↓, TumCMig↓, TumMeta↓, GSK‐3β↓, other↝,
8031- IVM,    Antiparasitic agents in oncology: Innovative mechanisms, emerging evidence and clinical potential in cancer treatment
- Review, Nor, NA
*AntiP↑, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, HH↓, Imm↑, CSCs↓, P-gp/ABCB1↓, Chl↓, angioG↓,
8029- IVM,    Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?
- Review, Var, NA
TumCP↓, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓, Akt↓, mTOR↓, BBB∅, ROS↑, MMP↓, Casp3↓, Casp9↑, TumCCA↑, P53↑, cMyc↓, MMP9↓, HSP27↓, ICD↑, Synergy↑, *AntiP↑,
8028- IVM,    Ivermectin as an Alternative Anticancer Agent: A Review of Its Chemical Properties and Therapeutic Potential
- Review, Var, NA
*BioAv↝, Apoptosis↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, TumPF↓, CSCs↓, eff↑, ChemoSen↑, mtDam↑, MMP↓, ATP↓, ROS↑, NF-kB↓, BAX↑, Casp3↑, Casp9↑, ICD↑, Ki-67↓, PSA↓, YAP/TEAD↓,
1167- IVM,    The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer
- vitro+vivo, Var, NA
Wnt↓, TCF↓, TumCP↓, Apoptosis↑, β-catenin/ZEB1↓, cycD1/CCND1↓,
7896- IVT,  VT,    Molecular targets of vitexin and isovitexin in cancer therapy: a critical review
- Review, Var, NA
chemoPv↑, Dose↝, ACE/ACE1↓, Ca+2↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Stroke↓, Apoptosis↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, TumAuto↑, HSP90↑, ER Stress↑, Hif1a↓, TumMeta↓, angioG↓, Tf↓, MAPK↓, PI3K↓, Akt↓, β-catenin/ZEB1↓, TumCCA↑, FOXO3↓, mTOR↓,
8071- KAE,    Cellular reprogramming and signaling control by kaempferol in colorectal cancer
- Review, CRC, NA
*toxicity↓, Risk↓, MMPs↓, VEGF↓, VEGFR1↓, Wnt↓, β-catenin/ZEB1↑, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, *BioAv↓, TumCCA↑, Apoptosis↑, Hif1a↓, ROS↑, TumCMig↓, TumMeta↓, PKM2↓, Glycolysis↓, DNAdam↑, HO-1↑, Ferroptosis↑, eff↑, Dose↝, BioAv↑,
8070- KAE,    Kaempferol: Paving the path for advanced treatments in aging-related diseases
- Review, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *NF-kB↓, *Akt↝, *β-catenin/ZEB1↝, *Aβ↓, *BDNF↑, Apoptosis↑, TumCCA↑, EMT↓, PI3K↓,

Showing Research Papers: 101 to 150 of 256
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 256

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↓, 2,   Catalase↑, 1,   ENOX2↓, 1,   GPx↓, 1,   GPx↑, 4,   GPx4↓, 6,   GPx4↝, 1,   GSH↓, 13,   GSH↑, 3,   GSH∅, 1,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 1,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   HO-1↓, 3,   HO-1↑, 9,   HO-2↑, 1,   Iron↑, 2,   c-Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 6,   lipid-P↑, 5,   MDA↓, 2,   MDA↑, 2,   MPO↓, 1,   NADH↓, 2,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 5,   NRF2↑, 9,   NRF2↝, 1,   p‑NRF2↓, 1,   PAO↑, 1,   Prx4↑, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 13,   ROS↑, 74,   ROS⇅, 4,   ROS↝, 2,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 3,   SOD↑, 4,   SOD2↓, 2,   TAC?, 1,   TrxR↓, 3,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 5,   CDC2↑, 1,   CDC25↓, 3,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   compV↓, 2,   EGF↓, 1,   ETC↓, 3,   ETC↑, 1,   Insulin↓, 1,   mitResp↓, 3,   mtDam↑, 5,   OCR↓, 4,   OXPHOS↓, 3,   OXPHOS↑, 1,   PDH↝, 1,   SIRT3↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 1,   ACLY↓, 1,   ACSL4↑, 2,   ALAT↓, 2,   ALAT↝, 1,   AMACR↓, 1,   AMPK?, 1,   AMPK↓, 1,   AMPK↑, 19,   ATP↓, 4,   CAIX/CA9↓, 1,   ECAR↓, 1,   FAO↓, 1,   FASN↓, 4,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↝, 1,   GlucoseCon↓, 2,   GlucoseCon∅, 1,   Glycolysis↓, 15,   GSK‐3β↓, 16,   GSK‐3β↑, 9,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 9,   HK1↓, 1,   HK2↓, 8,   HMG-CoA↓, 1,   lactateProd↓, 3,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 6,   lipoGen↓, 1,   MCT4↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PDK1 / PDPK1↓, 4,   p‑PDK1 / PDPK1↓, 1,   PKM2↓, 5,   PKM2↑, 1,   PKM2:PKM1↓, 2,   SCD1↓, 1,   SIRT1↓, 7,   SIRT1↑, 4,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   SSAT↑, 1,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 86,   Apoptosis↝, 1,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASK1↑, 2,   aSmase↝, 1,   BAD↑, 2,   Bak↑, 4,   BAX↓, 2,   BAX↑, 38,   BAX↝, 1,   Bax:Bcl2↑, 12,   Bcl-2↓, 44,   Bcl-2↑, 4,   Bcl-2↝, 1,   Bcl-xL↓, 6,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 3,   BIM↓, 1,   BIM↑, 5,   Casp↓, 1,   Casp↑, 15,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 48,   Casp3↝, 1,   cl‑Casp3↑, 13,   proCasp3↓, 1,   Casp7↑, 8,   cl‑Casp7↑, 1,   Casp8↑, 14,   cl‑Casp8↑, 2,   Casp9↑, 30,   cl‑Casp9↑, 5,   CellShr↑, 1,   cFLIP↓, 3,   CSR1↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 34,   Cyt‑c↝, 1,   Diablo↑, 5,   DR5↑, 17,   FADD↑, 1,   Fas↓, 1,   Fas↑, 11,   FasL↑, 2,   Ferroptosis↑, 9,   HEY1↓, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   ICD↑, 2,   iNOS↓, 8,   JWA↑, 1,   Mcl-1↓, 15,   Mcl-1↑, 1,   MDM2↓, 4,   p‑MDM2↓, 1,   MOMP↑, 2,   Necroptosis↑, 1,   p38↓, 1,   p38↑, 10,   p‑p38↑, 2,   PUMA↑, 1,   PUMA⇅, 1,   Pyro↑, 1,   survivin↓, 32,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 5,   XIAP↓, 14,   XIAP↝, 1,   YAP/TEAD↓, 5,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 82,   Akt↝, 1,   p‑Akt↓, 17,   AKT1↓, 1,   AMPKα↑, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   p‑cMET↑, 1,   CREB↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 21,   EGFR↑, 1,   EGFR↝, 1,   EphB4↓, 1,   ERK↓, 25,   ERK↑, 5,   p‑ERK↓, 7,   FGFR1↓, 1,   FLT4↓, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 4,   IGFR↓, 1,   p‑IGFR↓, 1,   IKKα↓, 7,   JAK↓, 6,   JAK1↓, 3,   JAK2↓, 4,   JNK↓, 4,   JNK↑, 10,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 16,   MAPK↑, 9,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 3,   Mst1↑, 1,   mTOR↓, 51,   mTOR↝, 1,   p‑mTOR↓, 4,   mTORC2↓, 1,   NRAS↓, 1,   p‑p42↓, 1,   p‑p42↑, 1,   p‑p70S6↓, 1,   P70S6K↓, 3,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 62,   PI3K↝, 1,   p‑PI3K↓, 3,   PIAS-3↑, 1,   PKCδ↓, 4,   PKCδ↑, 1,   PP2A↑, 2,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 13,   PTEN↝, 1,   Raf↓, 3,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 6,   Sp1/3/4↓, 8,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 49,   p‑STAT3↓, 3,   STAT5↓, 1,   STAT6↓, 2,   p‑STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 1,   ATF4↑, 5,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 6,   cJun↑, 1,   p‑cJun↑, 1,   cMyc↓, 41,   DNMT1↓, 8,   DNMT3A↓, 2,   DNMTs↓, 4,   FOXM1↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO4↑, 1,   H3↓, 1,   H3↑, 2,   ac‑H3↑, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 3,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 3,   HDAC3↓, 2,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-130a↓, 2,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-200b↑, 1,   miR-200c↑, 2,   miR-205↑, 1,   miR-21↓, 6,   miR-210↓, 1,   miR-218↑, 1,   miR-22↑, 1,   miR-224↓, 2,   miR-29b↓, 1,   miR-340↓, 2,   miR-34a↑, 5,   miR-384↑, 1,   miR-422a↑, 2,   miR-592↑, 1,   miR-99↑, 1,   Myc↓, 3,   MYCN↓, 1,   n-MYC↓, 2,   NDRG1↑, 1,   OCT4↓, 9,   other↓, 2,   other↑, 2,   other↝, 3,   PCAF↓, 1,   Shc↓, 1,   SOX2↓, 7,   SOX4↓, 3,   SOX4↑, 1,   SPP1↓, 1,   TCF-4↓, 2,   tumCV?, 1,   tumCV↓, 20,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 13,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 3,   ER Stress↑, 23,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 5,   Hsc70↓, 1,   HSF1↓, 1,   HSP27↓, 4,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP90↓, 6,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 5,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 3,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 7,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 10,   LC3s↓, 1,   p62↓, 3,   p62↑, 2,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 17,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   DFF45↑, 1,   DNA-PK↓, 1,   DNAdam↓, 1,   DNAdam↑, 19,   DNArepair↓, 2,   ERCC3↑, 1,   hTERT/TERT↓, 3,   p16↑, 2,   P53?, 1,   P53↓, 3,   P53↑, 31,   P53↝, 1,   ac‑P53↑, 1,   PARP↑, 6,   cl‑PARP↑, 26,   proPARP↓, 1,   PARP1↓, 1,   PARP1↑, 2,   cl‑PARP1↑, 1,   PCNA↓, 12,   PCNA↑, 1,   SIRT6↓, 1,   Telomerase↓, 8,   TOP1↓, 4,   TOP2↓, 5,   TOP2↑, 1,   TP53↑, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 3,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK1↑, 1,   CDK2↓, 11,   CDK2↑, 1,   CDK4↓, 19,   CDK4↑, 1,   CDK6↓, 9,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   Chk2↓, 2,   Cyc↓, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 58,   cycD1/CCND1↝, 1,   CycD3↓, 1,   cycE/CCNE↓, 9,   E2Fs↓, 4,   Ki-67↓, 11,   MAD↓, 1,   P21?, 1,   P21↑, 28,   P21↝, 1,   p27/CDKN1B↑, 10,   pRB↑, 1,   p‑pRB↓, 2,   RB1↑, 1,   p‑RB1↓, 6,   Securin↓, 2,   TAp63α↑, 1,   TumCCA↓, 3,   TumCCA↑, 76,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 4,   ALDH1A1↓, 5,   AXIN1↓, 1,   AXIN1↑, 2,   Axin2↓, 1,   Axin2↑, 1,   CD133↓, 14,   CD24↓, 3,   CD34↓, 1,   CDX2↓, 1,   CEBPB↓, 1,   cFos↓, 6,   cFos↑, 1,   CLOCK↓, 1,   cMYB↓, 1,   CSCs↓, 49,   CSCs↑, 1,   Diff↑, 3,   EP2↓, 1,   EP4/PTGER4↓, 1,   FBXW7↝, 1,   Gli↓, 2,   Gli1↓, 9,   HH↓, 10,   HMGCR↓, 1,   IGF-1↓, 3,   IGFBP1↑, 1,   IGFBP3↑, 1,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 11,   Let-7↑, 2,   LRP6↓, 6,   p‑LRP6↓, 2,   mTORC1↓, 5,   Nanog↓, 9,   Nestin↓, 3,   NKD2↑, 2,   NOTCH↓, 17,   NOTCH⇅, 1,   NOTCH1↓, 8,   NOTCH1↝, 1,   NOTCH2↓, 2,   NOTCH3↓, 3,   p300↓, 3,   Piezo1↑, 1,   PTCH1↓, 3,   Shh↓, 8,   Smo↓, 5,   STAT1↓, 1,   p‑STAT1↓, 1,   TOPflash↓, 2,   TumCG↓, 40,   TumCP?, 1,   TumCP↓, 76,   TumCP↑, 1,   Wnt↓, 123,   Wnt↑, 1,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AGRN↓, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 12,   AP-1↝, 2,   APC↑, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 11,   Ca+2↝, 1,   cal2↑, 2,   Cal9↑, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 1,   Chl↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 9,   E-cadherin↑, 45,   EMT↓, 70,   F-actin↓, 1,   FAK↓, 7,   p‑FAK↓, 1,   fascin↓, 2,   Fibronectin↓, 3,   GLI2↓, 3,   GLI3↑, 1,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB4↓, 1,   KRAS↓, 1,   LEF1↓, 5,   MALAT1↓, 4,   MET↓, 2,   MET↑, 1,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP14↓, 1,   MMP15↓, 1,   MMP16↓, 2,   MMP2↓, 45,   MMP2↑, 1,   MMP2↝, 1,   MMP3↓, 3,   MMP7↓, 10,   MMP9↓, 49,   MMPs↓, 18,   N-cadherin↓, 29,   N-cadherin↑, 1,   NCAM↓, 1,   NM23↑, 1,   p‑p44↓, 1,   p‑p44↑, 1,   p‑pax↓, 1,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 20,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 3,   SMAD3↓, 2,   p‑SMAD3↓, 2,   Snail↓, 36,   TET1↑, 2,   TGF-β↓, 10,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 2,   TIMP2↑, 2,   TRIB3↑, 2,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 2,   TumCI↓, 56,   TumCMig↓, 59,   TumCMig↑, 1,   TumMeta↓, 39,   TumMeta↑, 3,   TumPF↓, 1,   Twist↓, 13,   Tyro3↓, 1,   uPA↓, 14,   uPAR↓, 1,   UroPA↓, 1,   Vim↓, 47,   Vim↑, 2,   vinculin↓, 1,   Zeb1↓, 15,   ZEB2↑, 1,   β-catenin/ZEB1↓, 235,   β-catenin/ZEB1↑, 6,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↓, 2,   p‑β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 36,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 1,   ECM/TCF↓, 1,   HIF-1↓, 2,   Hif1a↓, 25,   Hif1a↝, 1,   LOX1↓, 1,   LymphAG↓, 1,   NO↓, 1,   NO↑, 1,   NO↝, 1,   VCAM-1↓, 2,   VEGF↓, 47,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   BBB↓, 1,   BBB↑, 1,   BBB∅, 1,   CLDN1↓, 5,   CLDN1↑, 1,   CLDN2↓, 1,   CTR1↑, 1,   GLUT1↓, 8,   MMP↓, 35,   MPT↑, 3,   NHE1↓, 1,   ZO-1↓, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CD44↓, 19,   CD44↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 47,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR2↓, 2,   CXCR4↓, 12,   DR4↑, 6,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 3,   IL12↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 7,   IL2↓, 1,   IL2↑, 6,   IL4↓, 1,   IL4↑, 1,   IL6↓, 19,   IL6↝, 1,   IL8↓, 3,   Imm↑, 11,   Imm↝, 1,   Inflam↓, 16,   LIF↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   MDSCs↓, 1,   MIP-1β↑, 1,   MIP2↓, 1,   NF-kB?, 2,   NF-kB↓, 79,   NF-kB↑, 1,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 1,   NLRP3↑, 1,   p50↓, 2,   p65↓, 4,   p65↑, 1,   p‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 4,   PGE2↓, 14,   PSA↓, 3,   PSA↝, 1,   RAGE↓, 1,   SOCS-3↑, 1,   SOCS1↑, 1,   TCF↓, 10,   TCF↑, 1,   TCF7/TCF1↓, 2,   TNF-α↓, 11,   TNF-α↑, 3,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,   pH↓, 1,   PLC↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AR↓, 10,   AR↝, 1,   ER-α36↓, 1,   Estro↝, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 4,   BioAv↓, 14,   BioAv↑, 13,   BioAv↝, 6,   BioEnh?, 1,   BioEnh↑, 3,   ChemoSen↑, 76,   ChemoSen⇅, 1,   ChemoSen∅, 1,   CompStab↓, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1B1↑, 1,   Dose?, 1,   Dose↑, 3,   Dose↝, 17,   Dose∅, 4,   eff↓, 9,   eff↑, 27,   eff↝, 6,   GSTA1↑, 1,   Half-Life↓, 7,   Half-Life↝, 2,   MDR1↓, 5,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 13,   P450↓, 2,   P450↝, 1,   RadioS↑, 26,   selectivity↑, 27,   selectivity↝, 1,   Synergy↑, 43,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT↝, 1,   ALB↑, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 10,   AR↝, 1,   ascitic↓, 1,   AST?, 1,   AST↓, 1,   AST↝, 1,   CEA↓, 2,   DBIL↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 21,   EGFR↑, 1,   EGFR↝, 1,   Ferritin↓, 1,   FOXM1↓, 1,   HEC1↓, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 3,   IBIL↓, 1,   IL6↓, 19,   IL6↝, 1,   KRAS↓, 1,   LDH↓, 3,   Myc↓, 3,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 4,   PSA↓, 3,   PSA↝, 1,   RAGE↓, 1,   TBIL↓, 1,   TP53↑, 1,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 23,   antiD↑, 1,   antiNeop↑, 3,   AntiTum↑, 7,   cachexia↓, 2,   cardioP↑, 4,   chemoP↑, 14,   chemoPv↑, 14,   ChemoSideEff↓, 4,   fatigue↓, 1,   FTO↑, 1,   hepatoP↑, 3,   IMPDH1↓, 1,   IMPDH2↓, 1,   Mucositis↓, 1,   neuroP↑, 3,   NKG2D↑, 1,   Obesity↓, 1,   OS↑, 7,   QoL↑, 5,   radioP↑, 4,   RenoP↑, 2,   Risk↓, 8,   Sleep↑, 1,   Symptoms∅, 1,   toxicity↓, 7,   toxicity↑, 1,   toxicity↝, 2,   TumVol↓, 7,   TumVol∅, 1,   TumW↓, 5,   TumW∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 874

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 1,   antiOx↑, 29,   Catalase↑, 9,   Fenton↓, 1,   GPx↑, 6,   GPx4↑, 2,   GSH↑, 7,   GSTs↑, 4,   H2O2↑, 1,   HDL↓, 1,   HO-1?, 1,   HO-1↑, 10,   i-Iron↓, 1,   lipid-P↓, 7,   MDA↓, 7,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NRF2↑, 18,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 30,   ROS↑, 2,   mt-ROS↓, 1,   SOD↑, 11,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 2,   TBARS↓, 1,   Trx1↑, 1,   VitC↑, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   ALAT↓, 3,   AMPK↑, 2,   ATP↑, 1,   cytoP450↓, 1,   FABP4↓, 1,   FASN↓, 1,   GSK‐3β↓, 5,   LDL↓, 1,   NADPH↓, 1,   SIRT1↑, 1,   SIRT1↝, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 3,   Bcl-xL↑, 1,   Casp3?, 1,   Casp3↓, 4,   Casp9↓, 2,   Ferroptosis↓, 2,   iNOS↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   Akt↝, 1,   p‑Akt↓, 1,   p‑Akt↑, 2,   p‑CREB↑, 2,   ERK↓, 1,   ERK↑, 2,   JAK2↑, 1,   JNK↓, 1,   MAPK↓, 4,   MAPK↑, 1,   mTOR↓, 1,   mTOR↑, 1,   PI3K↑, 2,   PKCδ↓, 1,   STAT↓, 1,   STAT3↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HOTAIR↑, 1,   miR-34b-5p↓, 1,   other↝, 1,   RUNX2↑, 1,   TCF-4↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↑, 1,   Diff↑, 2,   FGF↑, 1,   Ki-67↑, 1,   TumCP↓, 1,   Wnt↓, 2,   Wnt↑, 5,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2?, 1,   Ca+2↓, 1,   Ca+2↑, 3,   Ca+2↝, 1,   E-cadherin↑, 1,   EMT↓, 1,   FAK↑, 1,   LAMs↑, 1,   LRP1↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 3,   MUC1↑, 1,   OPN↑, 1,   Smad1↑, 1,   Smad7↑, 1,   STAC2↑, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↑, 10,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 5,   GLUT4↓, 1,   IBI↑, 2,   MMP↑, 1,   MUC19↓, 1,   MUC2↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 6,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 1,   IL10↑, 3,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 8,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 7,   IL8↓, 1,   Imm↑, 4,   INF-γ↑, 1,   Inflam?, 1,   Inflam↓, 35,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   NeuroI↓, 1,   NF-kB↓, 10,   p‑NF-kB↓, 1,   NLRP3↓, 2,   PGE2↓, 3,   RAGE↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 11,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 1,   AChE↓, 6,   BDNF↑, 6,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 7,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 2,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 14,   BioAv↑, 10,   BioAv↝, 9,   ChemoSen↑, 1,   CompStab↑, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 8,   eff↑, 4,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 5,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   ALP↑, 1,   AST↓, 4,   BMD↑, 3,   CRP↓, 1,   IL6↓, 7,   IRes↑, 1,   LDH↓, 1,   LDH↑, 1,   OCN↑, 1,   RAGE↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 4,   AntiArt↑, 3,   AntiCan↑, 3,   AntiDiabetic↑, 7,   AntiTum↑, 2,   cardioP?, 1,   cardioP↑, 4,   chemoP↑, 1,   chemoPv↑, 5,   cognitive↑, 5,   diuretic↑, 1,   hepatoP↑, 12,   Learn↑, 1,   memory↑, 11,   motorD↑, 1,   neuroP↑, 23,   Obesity↓, 2,   OS↑, 1,   Pain↓, 2,   radioP↑, 2,   RenoP↑, 3,   Sleep↑, 1,   Stress↓, 1,   Stroke↓, 1,   toxicity↓, 14,   toxicity∅, 2,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 2,   AntiP↑, 2,   AntiViral↑, 4,   Bacteria↓, 7,   Diar↓, 1,   GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 264

Scientific Paper Hit Count for: β-catenin/ZEB1, β-catenin/ZEB1
21 Curcumin
11 EGCG (Epigallocatechin Gallate)
10 Quercetin
9 Matrine
9 Resveratrol
7 Apigenin (mainly Parsley)
7 Fisetin
7 Honokiol
6 Luteolin
6 Sulforaphane (mainly Broccoli)
6 salinomycin
5 Astragalus
5 Berberine
5 Ivermectin
5 Lycopene
5 Magnetic Fields
4 Ashwagandha(Withaferin A)
4 Garcinol
4 isoquercitrin
4 Kaempferol
4 Thymoquinone
3 Allicin (mainly Garlic)
3 Boswellia (frankincense)
3 5-fluorouracil
3 Ginkgetin
3 HydroxyTyrosol
3 phytic acid, Inositol hexakisphosphate
3 Naringin
3 Nimbolide
3 Piperine
2 Cisplatin
2 Isovitexin
2 Artemisinin
2 Baicalein
2 Caffeic acid
2 Propolis -bee glue
2 Capsaicin
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Ursolic acid
2 Dandelion Root
2 Echinacea
2 Hydrogen Gas
2 Indole-3-carbinol
2 isoorientin
2 itraconazole
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Magnolol
2 Melatonin
2 Morin
2 Niclosamide (Niclocide)
2 Piperlongumine
2 Pterostilbene
2 α-Santalol/Sandalwood oil
2 Silymarin (Milk Thistle) silibinin
1 1,8-Cineole
1 3-bromopyruvate
1 Alpha-Lipoic-Acid
1 Anethole/trans-Anethole
1 Chemotherapy
1 Baicalin
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Bufalin/Huachansu
1 Brutieridin–Melitidin Mixture
1 Bromelain
1 Boron
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Coenzyme Q10
1 Crocetin
1 Cyclopamine
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Diindolylmethane
1 Dipyridamole
1 Ellagic acid
1 Gemcitabine (Gemzar)
1 Emodin
1 Ferulic acid
1 flavonoids
1 Fucoidan
1 Grapeseed extract
1 Isobavachalcone
1 Inositol
1 Isoliquiritigenin
1 Vitexin
1 lambertianic acid
1 methylseleninic acid
1 Magnetic Field Rotating
1 Zeolite
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Bacopa monnieri
1 L-Theanine
1 Orlistat
1 Phycocyanin
1 isoflavones
1 Rutin
1 buckwheat sprouts
1 Shikonin
1 Salvia miltiorrhiza
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Urolithin
1 VitK3,menadione
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:342  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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