cMyc Cancer Research Results

cMyc, cellular-MYC oncogene: Click to Expand ⟱
Source:
Type: oncogene
The MYC proto-oncogenes are among the most commonly activated proteins in human cancer. The oncogene c-myc, which is frequently over-expressed in cancer cells, is involved in the transactivation of most of the glycolytic enzymes including lactate dehydrogenase A (LDHA) and the glucose transporter GLUT1 [51,52]. Thus, c-myc activation is a likely candidate to promote the enhanced glucose uptake and lactate release in the proliferating cancer cell. The c-Myc oncogene is a ‘master regulator’ of both cellular growth and metabolism in transformed cells.
-C-myc is a common oncogene that enhances aerobic glycolysis in the cancer cells by transcriptionally activating GLUT1, HK2, PKM2 and LDH-A

Inhibitors (downregulate):
Curcumin
Resveratrol: downregulate c-Myc expression.
Epigallocatechin Gallate (EGCG)
Quercetin
Berberine: decrease c-Myc expression and repress its transcriptional activity.
Scientific Papers found: Click to Expand⟱
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, eff↑, survivin↓, XIAP↓, Synergy↑,
8635- MBZ,    The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma
- vitro+vivo, Melanoma, NA
TumCCA↑, cMyc↓, cl‑Casp3↑, cl‑PARP↑, eff↑, TumCP↓, BRAF↓, OS↑, TumCG↓, p‑MEK↓, p‑ERK↓,
8649- MBZ,    Mebendazole induces apoptosis via C-MYC inactivation in malignant ascites cell line (AGP01)
- in-vitro, GC, AGP01
TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, cMyc↓,
6538- MeSal,  ASA,    Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis
- in-vitro, CRC, NA
chemoPv↑, AMPK↑, NRF2↑, miR-34a↑, cMyc↓, tumCV↓, Apoptosis↑, TumCI↓, TumCMig↓, MET↑,
8486- MF,    Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics
- Review, Var, NA
Ca+2↑, TumCG↓, MMP↓, CellMemb↑, SOX2↓, Nanog↓, cMyc↓, CD44↓, CD133↓, P53↑, ROS↑, DNAdam↑, CDK1↓, CycB/CCNB1↓, TumCCA↑, TumCP↓, pH↓, TumCP↓, Telomerase↓, ChemoSen↑, TRPV1↝, Bax:Bcl2↑, Casp3↑, Akt↓, mTOR↓, mitA↑, ROS↓, P-gp/ABCB1↓, MDR1↓, RadioS↑, Apoptosis↑, GSH↓, lipid-P↑, Iron↑, Iron↓, Fenton↑,
3500- MF,    Moderate Static Magnet Fields Suppress Ovarian Cancer Metastasis via ROS-Mediated Oxidative Stress
- in-vitro, Ovarian, SKOV3
ROS↑, CSCs↓, CD44↓, SOX2↓, cMyc↓, TumMeta↓, TumCI↓, TumCMig↓, CD133↓, Nanog↓,
8694- MLT,    Melatonin inhibits glycolysis in hepatocellular carcinoma cells by downregulating mitochondrial respiration and mTORC1 activity
- in-vitro, Liver, NA
mitResp↓, ROS↑, mTORC1↓, cMyc↓, Glycolysis↓, HK2↓, LDHA↓,
1182- MushCha,    Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29 - in-vitro, CRC, SW-620 - in-vitro, CRC, DLD1
Apoptosis↑, TumCG↓, FASN↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, CDK8↓, Ki-67↓,
1269- NCL,    Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway
- in-vitro, Pca, DU145
STAT3↓, TumCG↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cMyc↓, Bcl-xL↓,
5253- NCL,    Niclosamide: Beyond an antihelminthic drug
- Review, Var, NA
TumCP↓, Apoptosis↑, EMT↓, β-catenin/ZEB1↓, TumCG↓, toxicity↓, Wnt↓, LRP6↓, Synergy↑, DR5↑, mTORC1↓, pH↓, CSCs↓, IL6↓, JAK1↓, STAT3↓, ChemoSen↑, TumCG↓, tumCV↓, NOTCH↓, NF-kB↓, EGFR↓, ROS↑, RadioS↑, cFos↓, cJun↓, E2Fs↓, cMyc↓, Half-Life↓, BioAv↝,
6775- Neem,  Nimb,    Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment
- Review, Nor, NA
*antiOx↑, P53↑, PTEN↑, NF-kB↓, PI3K↓, Akt↓, Bcl-2↓, VEGF↓, *Inflam↓, *COX2/PTGS2↓, *5LO↝, *Wound Healing↑, *Imm↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, *AntiViral↑, *Bacteria↑, *AntiBio↑, *AntiFungal↑, cMyc↓, BAX↓, IAP1↓, IAP2/BIRC3↓, Bcl-xL↓, survivin↓, XIAP↓, angioG↓,
6493- Nimb,    Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment
- in-vivo, CRC, HCT116 - vitro+vivo, CRC, HT29
TumCP↓, Apoptosis↑, NF-kB↓, IKKα↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, cMyc↓, cycD1/CCND1↓, MMP9↓, CXCR4↓, ICAM-1↓, VEGF↓, angioG↓, TumCG↓,
2421- PB,    Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c‐myc/hexokinase 2 pathway
- in-vitro, HCC, HCCLM3 - in-vivo, NA, NA - in-vitro, HCC, Bel-7402 - in-vitro, HCC, SMMC-7721 cell - in-vitro, Nor, L02
Glycolysis↓, Apoptosis↑, TumCP↓, lactateProd↓, GlucoseCon↓, HK2↓, ChemoSen↑, *toxicity↓, cMyc↓, PFK1↓, LDHA↓, cMyc↓, ChemoSen↑,
4920- PEITC,  Cisplatin,    PEITC restores chemosensitivity in cisplatin-resistant non-small cell lung cancer by targeting c-Myc/miR-424-5p
- vitro+vivo, NSCLC, A549
TumCG↓, ChemoSen↑, cMyc↓, PI3K↓, Akt↓, mTOR↓, BioAv↝, tumCV↓, ChemoSen↑,
4943- PEITC,    Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation
- in-vitro, Ovarian, OVCAR-3
TumCD↑, TumCP↓, Apoptosis↑, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Akt↓, ERK↓, cMyc↓, p38↑, JNK↑, eff↓,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
3597- PI,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, AD, NA - Review, Park, NA - Review, Var, NA
*NF-kB↓, *MAPK↓, *AP-1↓, *COX2/PTGS2↓, *NOS2↓, *IL1β↓, *TNF-α↓, *PGE2↓, *STAT3↓, *IL10↑, *IL4↓, *IL5↓, P53↑, MMP9↓, MMP2↓, cMyc↓, VEGF↓, STAT3↓, survivin↓, p65↓, *antiAll↑,
2940- PL,    Piperlongumine Induces Reactive Oxygen Species (ROS)-dependent Downregulation of Specificity Protein Transcription Factors
- in-vitro, PC, PANC1 - in-vitro, Lung, A549 - in-vitro, Kidney, 786-O - in-vitro, BC, SkBr3
ROS↑, TumCP↓, Apoptosis↑, eff↓, Sp1/3/4↓, cycD1/CCND1↓, survivin↓, cMyc↓, EGFR↓, cMET↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
2950- PL,    Overview of piperlongumine analogues and their therapeutic potential
- Review, Var, NA
AntiAg↑, neuroP↑, Inflam↓, NO↓, PGE2↓, MMP3↓, MMP13↓, TumCMig↓, TumCI↓, p38↑, JNK↑, NF-kB↑, ROS↑, FOXM1↓, TrxR1↓, GSH↓, Trx↓, cMyc↓, Casp3↑, Bcl-2↓, Mcl-1↓, STAT3↓, AR↓, DNAdam↑,
4694- PTS,    Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions
- Review, Var, NA
BioAv↑, AntiCan↑, Casp↑, TumCCA↑, angioG↓, TumMeta↓, MMP9↓, VEGF↓, CSCs↓, CD44↓, cMyc↓, ChemoSen↑, mTOR↓,
2408- PTS,    Pterostilbene suppresses the growth of esophageal squamous cell carcinoma by inhibiting glycolysis and PKM2/STAT3/c-MYC signaling pathway
- in-vitro, ESCC, NA
TumCP↓, TumCMig↓, PKA↓, GlucoseCon↓, lactateProd↓, PKM2↓, STAT3↓, cMyc↓,
4686- QC,    Quercetin suppresses endometrial cancer stem cells via ERα-mediated inhibition of STAT3 signaling
- in-vitro, EC, EMN8 - in-vitro, EC, EMN21
CSCs↓, ALDH1A1↓, cMyc↓, Nanog↓, OCT4↓, STAT3↓, JAK2↓, STAT3↓, eff↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27/CDKN1B↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2/PTGS2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
66- QC,    Emerging impact of quercetin in the treatment of prostate cancer
- Review, Pca, NA
CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt/(β-catenin)↓, PSA↓, VEGF↓, PARP↑, Casp3↑, Casp9↑, DR5↑, ROS⇅, Shh↓, P53↑, P21↑, EGFR↓, TumCCA↑, ROS↑, miR-21↓, TumCP↓, selectivity↑, PDGF↓, EGF↓, TNF-α↓, VEGFR2/KDR/Flk1↓, mTOR↓, cMyc↓, MMPs↓, GRP78/BiP↑, CHOP/DDIT3↑,
53- QC,    Quercetin regulates β-catenin signaling and reduces the migration of triple negative breast cancer
- in-vitro, BC, MDA-MB-231 - NA, NA, MDA-MB-468
E-cadherin↑, Vim↓, cycD1/CCND1↓, cMyc↓, EMT↓, TumCG↓, TumCMig↓, β-catenin/ZEB1↓, ChemoSen↑,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4/6↓, E2Fs↓, PCNA↓, cDC2↓, PTEN↑, MSH2↑, P21↑, EP300↑, BRCA1↑, NF2↑, TSC1↑, TGFβR1↑, P53↑, RB1↑, AKT1↓, cMyc↓, CDC7↓, cycF↓, CDC16↓, CUL4B↑, CBP↑, TSC2↑, HER2/EBBR2↓, BCR↓, TumCCA↑, chemoPv↑,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
916- QC,    Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells
- Review, Ovarian, NA
COX2/PTGS2↓, CRP↓, ER Stress↑, Apoptosis↑, GRP78/BiP↑, CHOP/DDIT3↑, p‑STAT3↓, PI3K↓, Akt↓, mTOR↓, cMyc↓, cycD1/CCND1↓, cFLIP↓, IL6↓, IL10↓,
4657- RES,    Resveratrol, cancer and cancer stem cells: A review on past to future
- Review, Var, NA
CSCs↓, CD133↓, Shh↓, Twist↓, Snail↓, MMP2↓, MMP9↓, Smad1↓, CD44↓, ALDH1A1↓, OCT4↓, Nanog↓, STAT3↓, survivin↓, cycD1/CCND1↓, COX2/PTGS2↓, cMyc↓,
4666- RES,    Structural modification of resveratrol analogue exhibits anticancer activity against lung cancer stem cells via suppression of Akt signaling pathway
- in-vitro, Lung, H23 - in-vitro, Lung, H292 - in-vitro, Lung, A549
CSCs↓, eff↑, Akt↓, GSK‐3β↑, SOX2↓, cMyc↓, TumCCA↑, ROS↑, Apoptosis↑,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, Synergy↑, HK2↓, ROS↑, MMP↓,
2472- RES,    Resveratrol Restores Sirtuin 1 (SIRT1) Activity and Pyruvate Dehydrogenase Kinase 1 (PDK1) Expression after Hemorrhagic Injury in a Rat Model
- in-vivo, Nor, NA
*SIRT1↑, *PGC-1α↑, *cMyc↑, *PDK1 / PDPK1↓,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2/PTGS2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2/PTGS2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,
3095- RES,    Resveratrol suppresses migration, invasion and stemness of human breast cancer cells by interfering with tumor-stromal cross-talk
- in-vitro, BC, NA
TumCP↓, TumCMig↓, TumCI↓, cycD1/CCND1↓, cMyc↓, MMP2↓, MMP9↓, SOX2↓, Akt↓, STAT3↓, α-SMA↓,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
1140- SIL,    Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth
- in-vitro, PC, AsPC-1 - in-vivo, PC, NA - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
TumCG↓, Glycolysis↓, cMyc↓, STAT3↓, TumCP↓, Weight∅, Strength↑, DNAdam↑, Casp3↑, Casp9↑, GLUT1↓, HK2↓, LDHA↓, GlucoseCon↓, lactateProd↓, PPP↓, Ki-67↓, p‑STAT3↓, cachexia↓,
2234- SK,    Shikonin Suppresses Cell Tumorigenesis in Gastric Cancer Associated with the Inhibition of c-Myc and Yap-1
- in-vitro, GC, NA
TumCP↓, TumCI↓, TumCMig↓, cMyc↓, YAP/TEAD↓,
5331- TFdiG,    Anti-Cancer Properties of Theaflavins
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑Akt↓, p‑mTOR↓, PI3K↓, cMyc↓, P53↑, ROS↑, NF-kB↓, MMP9↓, MMP2↓, TumVol↓, PSA↓, TumCCA↑, VEGF↓, Hif1a↓, CDK2↓, CDK4↓, GSH↓, Dose↑, BioAv↓, BioAv↓, BioAv↑,
2095- TQ,    Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis
- Review, Var, NA
TumCCA↑, Apoptosis↑, ROS↑, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, cl‑PARP↑, P53↑, P21↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, MMP9↓, VEGF↓, ChemoSen↑,
2097- TQ,    Crude extract of Nigella sativa inhibits proliferation and induces apoptosis in human cervical carcinoma HeLa cells
- in-vitro, Cerv, HeLa
Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8↑, cl‑PARP↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, P53↑, P21↑, TumCP↓, Apoptosis↓, selectivity↑,

Showing Research Papers: 101 to 150 of 166
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 166

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   Catalase↓, 1,   Catalase↑, 1,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 4,   GSH↓, 11,   GSH↑, 5,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 3,   HO-1↑, 6,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 1,   lipid-P↓, 2,   lipid-P↑, 3,   MDA↓, 1,   MDA↑, 1,   MPO↓, 1,   NQO1↑, 1,   Nrf1↓, 1,   NRF2↓, 8,   NRF2↑, 8,   p‑NRF2↓, 1,   Prx4↑, 1,   PYCR1↓, 1,   ROS↓, 13,   ROS↑, 73,   ROS⇅, 3,   ROS↝, 2,   ROS∅, 1,   i-ROS↑, 2,   mt-ROS↑, 1,   SOD↓, 5,   SOD↑, 5,   SOD1↑, 1,   SOD2↑, 1,   TBARS↓, 1,   Trx↓, 1,   TrxR↓, 3,   TrxR1↓, 2,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   Bfl-1↓, 1,   CDC16↓, 1,   CDC2↓, 1,   CDC2↑, 1,   CDC25↓, 3,   EGF↓, 2,   mitResp↓, 2,   mtDam↑, 4,   OCR↓, 2,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   PDH↓, 2,   PDH↑, 1,   PGC-1α↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 3,   ACC↓, 1,   ACC↑, 1,   ACLY↓, 1,   ALAT↓, 2,   AMPK↑, 9,   ATP↓, 6,   mt-ATP↓, 1,   CAIX/CA9↓, 1,   ECAR↓, 3,   ECAR↝, 1,   FASN↓, 2,   G6PD↓, 1,   GAPDH↓, 1,   GLS↓, 3,   GLS↑, 1,   GlucoseCon↓, 11,   GlucoseCon↑, 1,   glut↓, 1,   GlutaM↓, 1,   GlutMet↑, 1,   Glycolysis↓, 30,   Glycolysis↑, 1,   GSK‐3β↓, 7,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 5,   HK2↓, 18,   HK2↑, 1,   lactateProd↓, 12,   lactateProd↑, 1,   LDHA↓, 12,   LDHA↑, 1,   NADPH↓, 1,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 4,   p‑PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFK↓, 2,   PFK1↓, 1,   PKM2↓, 10,   p‑PKM2↓, 1,   PKM2:PKM1↓, 2,   PPP↓, 2,   Pyruv↑, 1,   SIRT1↓, 3,   SIRT1↑, 3,   SIRT2↓, 2,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 65,   ASK1↑, 1,   BAD↑, 2,   Bak↑, 3,   BAX↓, 5,   BAX↑, 36,   Bax:Bcl2↑, 15,   Bcl-2↓, 50,   Bcl-2↑, 3,   Bcl-xL↓, 22,   BID↑, 1,   BIM↓, 1,   BIM↑, 2,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 9,   Casp10↑, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 4,   Casp3↑, 47,   cl‑Casp3↑, 8,   proCasp3↓, 1,   proCasp3↑, 1,   Casp7↑, 12,   cl‑Casp7↑, 1,   Casp8↑, 10,   cl‑Casp8↑, 3,   Casp9↑, 30,   cl‑Casp9↑, 4,   cFLIP↓, 4,   Cyt‑c↑, 21,   Diablo↑, 4,   DIDO1/DIO-1↑, 1,   DR5↓, 1,   DR5↑, 10,   FADD↑, 1,   Fas↑, 5,   FasL↑, 1,   Ferroptosis↑, 3,   GSDME-N↑, 1,   IAP1↓, 7,   IAP2/BIRC3↓, 6,   ICD↑, 1,   iNOS↓, 5,   Mcl-1?, 1,   Mcl-1↓, 8,   Mcl-1↑, 1,   MDM2↓, 7,   NAIP↓, 1,   necrosis↑, 1,   NOXA↑, 3,   oncosis↑, 1,   p38↑, 9,   p‑p38↓, 1,   p‑p38↑, 1,   PUMA↑, 5,   Pyro↑, 1,   survivin↓, 43,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↑, 3,   XIAP?, 1,   XIAP↓, 17,   YAP/TEAD↓, 4,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 49,   Akt↑, 4,   p‑Akt↓, 9,   p‑Akt↑, 1,   AKT1↓, 3,   Akt2↓, 1,   BRAF↓, 1,   CaMKII ↓, 3,   CDC7↓, 1,   CK2↓, 2,   cMET↓, 3,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 17,   ERK↓, 19,   ERK↑, 3,   p‑ERK↓, 6,   FGFR1↓, 4,   FGFR2↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   IKKα↓, 6,   IKKα↑, 1,   p‑IKKα↓, 1,   JAK↓, 4,   JAK1↓, 4,   JAK2↓, 8,   JNK↓, 1,   JNK↑, 8,   p‑JNK↓, 1,   MAPK↓, 9,   MAPK↑, 2,   p‑MAPK↑, 1,   MEK↓, 1,   p‑MEK↓, 2,   mTOR↓, 29,   p‑mTOR↓, 6,   mTORC2↓, 1,   p70S6↓, 1,   P90RSK↓, 1,   PI3K↓, 38,   PI3K↑, 1,   PKA↓, 1,   PKCδ↓, 5,   PTEN↑, 14,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 6,   Sp1/3/4↓, 6,   Sp1/3/4↑, 1,   STAT↓, 2,   STAT3↓, 45,   p‑STAT3↓, 9,   STAT6↓, 2,   STK11/LKB1↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 3,   ATF4↝, 1,   BRD4↓, 1,   CBP↑, 1,   cJun↓, 4,   cJun↑, 2,   cMyc↓, 158,   cMyc↑, 4,   cMyc↝, 1,   p‑cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 3,   EZH2↓, 1,   FOXM1↓, 2,   FOXO1↑, 1,   FOXO3↑, 2,   p‑FOXO3↓, 1,   H3↑, 1,   ac‑H3↑, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   HES1↓, 1,   IRF1↑, 1,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-130a↓, 1,   miR-134↑, 1,   miR-192-5p↑, 1,   miR-195↑, 1,   miR-199↑, 1,   miR-200b↑, 1,   miR-206↑, 1,   miR-21↓, 2,   miR-21↑, 2,   miR-221↑, 1,   miR-222↑, 1,   miR-27a-3p↓, 2,   miR-326-5p↑, 1,   miR-339-5p↝, 1,   miR-34a↑, 5,   miR-34b-5p↑, 2,   miR-384↑, 1,   miR-99↑, 1,   Myc↓, 3,   n-MYC↓, 1,   OCT4↓, 10,   other↓, 1,   other↑, 2,   other↝, 3,   SOX2↓, 8,   SOX4↓, 1,   SOX4↑, 1,   tumCV?, 1,   tumCV↓, 16,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 11,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 15,   GRP78/BiP↑, 7,   HSP27↓, 3,   HSP70/HSPA5↓, 4,   HSP90↓, 3,   IRE1↑, 1,   PERK↑, 3,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 2,   LC3II↓, 1,   LC3II↑, 4,   p62↓, 1,   p62↑, 2,   TumAuto↓, 1,   TumAuto↑, 11,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↑, 1,   CUL4B↑, 1,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 20,   mt-DNAdam↑, 1,   HR↓, 1,   hTERT/TERT↓, 4,   MSH2↑, 1,   p16↑, 2,   P53↓, 1,   P53↑, 41,   p‑P53↓, 1,   p‑P53↑, 3,   PARP↓, 2,   PARP↑, 7,   cl‑PARP↑, 28,   proPARP↓, 1,   PARP1↓, 1,   PARP1↑, 4,   cl‑PARP1↑, 1,   PCNA↓, 19,   RAD51↓, 1,   SIRT6↑, 1,   Telomerase↓, 7,   TOP1↓, 2,   TOP2↓, 5,   TP53↑, 2,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

BRD4↓, 1,   CDK1↓, 7,   CDK2↓, 17,   CDK2↑, 1,   CDK4↓, 25,   CDK4/6↓, 2,   CDK6↓, 12,   CDK8↓, 3,   CHK1↓, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   p‑Chk2↑, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 12,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 67,   CycD3↓, 1,   cycE/CCNE↓, 9,   cycE/CCNE↑, 2,   cycE1↓, 1,   cycF↓, 1,   E2Fs↓, 3,   Ki-67↓, 8,   mitA↑, 1,   P21?, 1,   P21↓, 2,   P21↑, 29,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 14,   pRB↑, 1,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   TumCCA↓, 1,   TumCCA↑, 68,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   ALDH1A1↓, 5,   Axin2↑, 1,   CD133↓, 8,   CD133↑, 1,   CD24↓, 1,   cFos↓, 5,   CSCs↓, 23,   CSCs↑, 1,   EP300↑, 1,   FGF↓, 2,   Gli↓, 2,   Gli1↓, 4,   HH↓, 2,   IGF-1↓, 2,   IGFBP3↑, 1,   Ki-67↓, 8,   Let-7↑, 2,   LGR5↓, 1,   LRP6↓, 1,   mTORC1↓, 6,   Nanog↓, 12,   Nestin↓, 2,   NF2↑, 1,   NICD↓, 1,   NOTCH↓, 8,   NOTCH↑, 1,   NOTCH1↓, 4,   NOTCH1↑, 2,   NOTCH3↓, 1,   PTCH1↓, 3,   PTCH2↓, 1,   SFRP5↑, 1,   Shh↓, 8,   Smo↓, 3,   STAT1↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG↓, 39,   TumCP↓, 54,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt↓, 21,   Wnt/(β-catenin)↓, 5,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 4,   APC↑, 1,   Ca+2↑, 10,   Ca+2↝, 2,   Cav1↑, 2,   Cdc42↑, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 7,   E-cadherin↑, 22,   EMT↓, 31,   EMT↝, 1,   FAK↓, 2,   p‑FAK↓, 2,   Fibronectin↓, 2,   GLI2↓, 2,   ITGB1↑, 1,   KRAS↓, 1,   LEF1↓, 2,   MALAT1↓, 1,   MET↓, 1,   MET↑, 1,   MMP13↓, 1,   MMP16↓, 1,   MMP2↓, 33,   MMP3↓, 2,   MMP7↓, 6,   MMP9↓, 42,   MMP9↑, 1,   MMPs↓, 15,   N-cadherin↓, 15,   NCAM↑, 1,   PDGF↓, 3,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 8,   Smad1↓, 1,   SMAD3↓, 1,   SMAD3↑, 1,   Snail↓, 14,   TET1↑, 1,   TGF-β↓, 8,   TIMP1↓, 2,   TIMP1↑, 3,   TIMP2↓, 2,   TIMP2↑, 4,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↑, 1,   TumCI↓, 26,   TumCMig↓, 26,   TumCMig↑, 1,   TumMeta↓, 22,   TumMeta↑, 2,   Twist↓, 11,   TXNIP↑, 1,   uPA↓, 10,   uPAR↓, 1,   UroPA↓, 1,   Vim↓, 23,   Zeb1↓, 6,   α-SMA↓, 1,   β-catenin/ZEB1↓, 40,   β-catenin/ZEB1↑, 1,   p‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 35,   angioG↑, 1,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   HIF-1↓, 1,   Hif1a↓, 26,   Hif1a↑, 1,   LOX1↓, 1,   NO↓, 3,   NO↑, 1,   TXA2↓, 1,   VCAM-1↓, 1,   VEGF↓, 48,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 10,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   BBB∅, 1,   CellMemb↑, 1,   CLDN2↓, 1,   GLUT1↓, 10,   GLUT1↑, 1,   GLUT3↓, 1,   KCNH2/hERG↓, 1,   MMP↓, 21,   MPT↑, 1,   NHE1↓, 1,   SLC12A5↓, 1,   TRPV1↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 10,   cDC2↓, 1,   COX1↓, 3,   COX2/PTGS2↓, 35,   COX2/PTGS2↑, 1,   CXCL12↓, 1,   CXCR4↓, 11,   DR4↑, 1,   ICAM-1↓, 4,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 6,   IL12↓, 2,   IL1β↓, 7,   IL2↓, 1,   IL2↑, 3,   IL4↑, 1,   IL6↓, 23,   IL7↓, 1,   IL8↓, 5,   IL8↑, 1,   Imm↑, 1,   Inflam↓, 10,   MCP1/CCL2↓, 1,   MDSCs↓, 1,   MIP2↓, 1,   NF-kB↓, 57,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 2,   p50↓, 1,   p65↓, 4,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-L1↓, 3,   PGE2↓, 8,   PSA↓, 5,   RAGE↓, 1,   RANTES↓, 1,   SOCS1↑, 1,   TCF↓, 5,   TCF7/TCF1↓, 1,   TLR4↓, 1,   TNF-α↓, 13,   TNF-α↑, 1,   TRAF1↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 8,   ER(estro)↓, 1,   PPARγ↓, 2,   PPARγ↑, 2,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 16,   BioAv↑, 12,   BioAv↝, 3,   BioEnh?, 1,   BioEnh↑, 4,   CBR1↓, 1,   ChemoSen↓, 2,   ChemoSen↑, 45,   ChemoSen⇅, 1,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 1,   Dose↑, 3,   Dose↝, 6,   Dose∅, 1,   eff↓, 12,   eff↑, 26,   eff↝, 2,   GSTA1↑, 1,   Half-Life↓, 8,   Half-Life↑, 1,   Half-Life↝, 4,   MDR1↓, 6,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 7,   P450↓, 3,   RadioS↑, 19,   selectivity↑, 22,   Synergy↑, 38,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 8,   AST↓, 2,   BRAF↓, 1,   BRCA1↑, 1,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 17,   EZH2↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 23,   KRAS↓, 1,   LDH↓, 4,   LDH↑, 1,   Myc↓, 3,   PD-L1↓, 3,   PSA↓, 5,   RAGE↓, 1,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 13,   cachexia↓, 1,   cardioP↑, 4,   chemoP↑, 5,   chemoPv↑, 4,   ChemoSideEff↓, 2,   hepatoP↑, 3,   neuroP↑, 2,   Obesity↓, 1,   OS↑, 5,   radioP↑, 2,   RenoP↑, 2,   Risk↓, 1,   Strength↑, 1,   TGFβR1↑, 1,   toxicity↓, 5,   toxicity∅, 1,   TumVol↓, 4,   TumW↓, 4,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  
Total Targets: 678

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 2,   antiOx↑, 18,   Catalase↑, 8,   GPx↑, 6,   GSH↑, 12,   GSTs↑, 1,   H2O2↓, 1,   HO-1?, 1,   HO-1↑, 7,   lipid-P↓, 8,   MDA↓, 10,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 11,   ROS↓, 21,   ROS↑, 1,   SOD↑, 11,   Trx1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↝, 1,   ALAT↓, 4,   AMPK↑, 4,   p‑AMPK↑, 1,   ATP↑, 1,   FASN↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 2,   LDHA↑, 1,   NAD↑, 1,   PDK1 / PDPK1↓, 1,   SIRT1↑, 4,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↑, 3,   Casp↓, 1,   Casp3↓, 4,   Casp9↓, 2,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   GSDMD↓, 1,   iNOS↓, 3,   iNOS↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   ERK↑, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   PI3K↓, 1,   STAT3↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 2,   cMyc↑, 1,   p‑cMyc↑, 1,   HDAC2↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Ca+2↓, 1,   LRP1↑, 1,   MMP13↓, 1,   MMP9↓, 2,   MUC1↑, 1,   TGF-β↓, 2,   TumCI↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   eNOS↓, 1,   eNOS↑, 1,   Hif1a↓, 2,   NO↓, 2,   NO↑, 1,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 1,   MMP↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 10,   IL10↓, 1,   IL10↑, 3,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 6,   IL4↓, 1,   IL5↓, 1,   IL6↓, 7,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 25,   Inflam↑, 2,   IRF3↓, 1,   MCP1/CCL2↓, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 7,   PGE2↓, 3,   RAGE↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 9,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 5,   BDNF↑, 1,   GABA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 5,   tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↝, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 5,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↑, 1,   GSTA1↑, 1,   Half-Life↑, 1,   Half-Life↝, 1,   P450↓, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 1,   AST↓, 4,   BMD↑, 2,   BP↓, 2,   CRP↓, 3,   IL6↓, 7,   LDH↓, 3,   NOS2↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 4,   AntiArt↑, 2,   AntiCan↓, 1,   AntiCan↑, 2,   AntiDiabetic↑, 4,   cardioP↑, 12,   cognitive↑, 5,   diuretic↑, 1,   hepatoP↑, 15,   memory↑, 6,   motorD↑, 1,   neuroP↑, 22,   Obesity↓, 2,   Pain↓, 1,   RenoP↑, 4,   Stroke↓, 2,   toxicity↓, 4,   toxicity∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiP↑, 1,   AntiViral↑, 3,   Bacteria↓, 1,   Bacteria↑, 1,   GutMicro↑, 1,  
Total Targets: 176

Scientific Paper Hit Count for: cMyc, cellular-MYC oncogene
12 Curcumin
10 Quercetin
9 Thymoquinone
8 Resveratrol
6 Baicalein
5 Luteolin
4 Artemisinin
4 Berbamine
4 Berberine
4 Lycopene
4 Piperlongumine
4 Silymarin (Milk Thistle) silibinin
3 Ashwagandha(Withaferin A)
3 EGCG (Epigallocatechin Gallate)
3 lambertianic acid
2 Apigenin (mainly Parsley)
2 Aspirin
2 Betulinic acid
2 Boswellia (frankincense)
2 brusatol
2 Chrysin
2 Ellagic acid
2 Sulforaphane (mainly Broccoli)
2 Emodin
2 Ferulic acid
2 Fisetin
2 Gambogic Acid
2 mebendazole
2 Magnetic Fields
2 Niclosamide (Niclocide)
2 Nimbolide
2 Phenethyl isothiocyanate
2 Piperine
2 Pterostilbene
2 Ursolic acid
2 Urolithin
2 Vitamin K2
1 3-bromopyruvate
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Astaxanthin
1 Biochanin A
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 Boron
1 Chemotherapy
1 Caffeic acid
1 Metformin
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Propolis -bee glue
1 Crocetin
1 Cucurbitacin
1 Gemcitabine (Gemzar)
1 Cynaropicrin
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Genistein (soy isoflavone)
1 Estrogen
1 Evodiamine
1 flavonoids
1 Galloflavin
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Honokiol
1 Indole-3-carbinol
1 Isobavachalcone
1 phytic acid, Inositol hexakisphosphate
1 Inositol
1 Ivermectin
1 Kaempferol
1 Licorice
1 Magnolol
1 Matrine
1 Methyl salicylate / Sweet Birch oil
1 Melatonin
1 Mushroom Chaga, Inonotus obliquus
1 Neem
1 Phenylbutyrate
1 Cisplatin
1 salinomycin
1 Shikonin
1 Aflavin-3,3′-digallate
1 triptolide
1 Vitamin C (Ascorbic Acid)
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:35  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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