Bax:Bcl2 Cancer Research Results

Bax:Bcl2, Bax:Bcl2 ratio: Click to Expand ⟱
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Bax and Bcl-2 are the major members of Bcl-2 family that play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction.
Bax/Bcl-2 ratio is typically significantly lower in tumors.
Scientific Papers found: Click to Expand⟱
7612- I3C,    Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells
- in-vitro, Nor, MCF10
selectivity↑, Bax:Bcl2↓, Bcl-xL↓, BAX↑, MMP↓, Cyt‑c↑, TumCD↑,
7679- iod,    Molecular iodine impairs chemoresistance mechanisms, enhances doxorubicin retention and induces downregulation of the CD44+/CD24+ and E-cadherin+/vimentin+ subpopulations in MCF-7 cells resistant to low doses of doxorubicin
- in-vivo, BC, MCF7
AntiTum↑, tumCV↓, Apoptosis↑, Bax:Bcl2↑, Bcl-2↓, MDR1↑, PPARγ↑, CD44↓,
7686- iod,    Molecular Iodine Exhibited Differential Antiproliferative Actions in Progenitor and Stem Populations from Chemoresistant Cancer Cells
- vitro+vivo, BC, MCF7
PPARγ↑, Apoptosis↑, Bax:Bcl2↑, CSCs↓, NRF2↑, tumCV↓, TumCI↓,
7689- iod,    Uptake and antitumoral effects of iodine and 6-iodolactone in differentiated and undifferentiated human prostate cancer cell lines
- in-vitro, Nor, RWPE-1 - in-vitro, Pca, LNCaP - vitro+vivo, Pca, DU145
Bax:Bcl2↑, Casp↑, TumCG↓,
7746- ISL,    Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway
- vitro+vivo, CRC, SW480 - vitro+vivo, CRC, HCT116
AntiCan↑, tumCV↓, Apoptosis↑, TumCCA↑, TumCG↓, PI3K↓, Akt↓, p‑Akt↓, p‑GSK‐3β↓, CDK1↓, NF-kB↓, Bcl-2↓, ERβ/ESR2↑, BAX↑, Bax:Bcl2↑, ROS↑,
7760- ISL,    Pharmacological Potentials and Delivery Strategies of Isoliquiritigenin: Challenges and Advances in Enhancing Bioavailability
- Review, Nor, NA
*BioAv↓, GlucoseCon↓, LDH↓, PDK1 / PDPK1↓, Glycolysis↓, mt-OXPHOS↓, Bax:Bcl2↓, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, Hif1a↓, ROS↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *ROS↓, *NF-kB↓, *NLRP3↓, *Pyro↓, *antiPs↑, *IL6↓, *IL8↓, CompStab↑, BioAv↑, BioAv↑,
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,
7780- ISL,    Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response
- in-vivo, Nor, NA
*hepatoP↑, *ROS↓, *PGC-1α↝, *NRF2↑, *HO-1↑, *NQO1↝, *Keap1↝, *GCLC↝, *GCLM↝, *NLRP3↓, *IL1β↓, *IL6↓, *TNF-α↓, *MIP2↓, *Bax:Bcl2↓, *cl‑Casp3↓, *Inflam↓, *Apoptosis↓,
7865- isoO,    Isoorientin inhibits oxidative stress to ameliorate cognitive dysfunction in type 2 diabetes mice via GSK3β/Nrf2 axis
- in-vivo, Diabetic, NA
*cognitive↑, *PSD95↑, *BDNF↑, *Bax:Bcl2↓, *cl‑Casp3↓, *ROS↓, *mtDam↓, *GSK‐3β↓, *NRF2↑, *HO-1↑, *p‑tau↓, *neuroP↑,
7854- isoO,    Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
- in-vitro, Liver, HepG2
TumCD↑, selectivity↑, *toxicity↓, cl‑PARP↑, DNAdam↑, Bax:Bcl2↑, MMP↓, Cyt‑c↑, Casp3↑, ROS↑, NO↑, p‑Akt↓, FOXO4↑, eff↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
7794- ISQ,    Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↓, Apoptosis↑, TumAuto↑, AMPK↑, TumCG↓, ATG5↑, Beclin-1/ATG6↑, p‑mTOR↓, Casp3↑, cl‑PARP↑, Bax:Bcl2↑, LC3II↑, p62↓,
9231- ITCs,  Cisplatin,  AITC,  BITC,    Isothiocyanates inhibit the cisplatin-induced apoptosis and inflammation in human kidney HEK-293 cells
- in-vitro, Nor, HEK293
*ROS↓, *NO↓, *chemoP↑, *MAPK↓, *Bax:Bcl2↓, *Apoptosis↓, *RenoP↑,
8024- IVM,    Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway
- vitro+vivo, ESCC, KYSE-30 - in-vitro, ESCC, NE3
TumCP↓, mtDam↑, Apoptosis↑, ROS↑, NF-kB↓, Bax:Bcl2↑, LDH↝, TumCCA↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, eff↓,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- in-vitro, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
8045- IVM,    Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway
- in-vitro, Cerv, HeLa
tumCV↓, TumCCA↑, DNA-PK↑, ChrMod↝, MMP↓, Bax:Bcl2↑, Cyt‑c↓, Casp9↑, Casp3↑, ROS↑, TumCMig↓,
1927- JG,    Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway
- in-vitro, GC, SGC-7901
Apoptosis↑, ROS↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, Casp3?, Bax:Bcl2↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8259- LCA,    Modulation of bcl-2 and cytotoxicity by licochalcone-A, a novel estrogenic flavonoid
- in-vitro, BC, MCF7 - in-vitro, AML, HL-60
ChemoSen↑, Apoptosis↑, cl‑PARP↑, Bcl-2↓, Bax:Bcl2↑,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
2913- LT,    Luteolin induces apoptosis by impairing mitochondrial function and targeting the intrinsic apoptosis pathway in gastric cancer cells
- in-vitro, GC, HGC27 - in-vitro, BC, MCF7 - in-vitro, GC, MKN45
TumCP↓, MMP↓, Apoptosis↑, ROS↑, SOD↓, ATP↓, Bax:Bcl2↑, TumCCA↑,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE/β-secretase↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *Synergy↑,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
8407- Lyco,    Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines
- in-vitro, Pca, LNCaP
CholSyn↓, HMGCR↓, RAS↓, NF-kB↓, ROS↓, p‑Jun↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, p‑Akt↓, P21↑, p27/CDKN1B↑, P53↑, Bax:Bcl2↑,
4777- Lyco,    Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells
- in-vitro, GC, AGS
*antiOx↑, tumCV↓, DNAdam↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, ROS↓, NF-kB↓, COX2/PTGS2↓, EGFR↓, p38↓,
4779- Lyco,    Lycopene Inhibits Reactive Oxygen Species-Mediated NF-κB Signaling and Induces Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, PANC1
ROS↓, NF-kB↓, tumCV↓, Casp3↑, Apoptosis↑, OCR↓, MMP↓, CIP2A↓, survivin↓, Casp3↑, Bax:Bcl2↑,
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2/PTGS2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
1013- Lyco,    Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells
- in-vitro, GC, AGS
Apoptosis↑, DNAdam↑, Bax:Bcl2↑, ROS↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, APC↑, β-TRCP↑, cMyc↓, cycD1/CCND1↓,
8519- MAG,    Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway
- vitro+vivo, Gall, NA
TumCG?, TumCCA↑, mt-Apoptosis↑, P53↑, P21↑, cycD1/CCND1↓, CDC25↓, CDK2↓, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, cl‑PARP↑,
4533- MAG,    Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways
- in-vitro, GC, SGC-7901
AntiCan↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bax:Bcl2↑, MMP↓, Casp3↑, PI3K↓, Akt↓,
8538- Matr,    Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling
- in-vitro, BC, MDA-MB-231 - ex-vivo, BC, MDA-MB-231
TumCP↓, Synergy↑, Apoptosis?, Bax:Bcl2↑, TumCI↓, MMP9↓, MMP2↓, Akt↓, NF-kB↓, VEGFR1↓, BioAv↝,
8486- MF,    Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics
- Review, Var, NA
Ca+2↑, TumCG↓, MMP↓, CellMemb↑, SOX2↓, Nanog↓, cMyc↓, CD44↓, CD133↓, P53↑, ROS↑, DNAdam↑, CDK1↓, CycB/CCNB1↓, TumCCA↑, TumCP↓, pH↓, TumCP↓, Telomerase↓, ChemoSen↑, TRPV1↝, Bax:Bcl2↑, Casp3↑, Akt↓, mTOR↓, mitA↑, ROS↓, P-gp/ABCB1↓, MDR1↓, RadioS↑, Apoptosis↑, GSH↓, lipid-P↑, Iron↑, Iron↓, Fenton↑,
8685- MLT,    Melatonin acts synergistically with pazopanib against renal cell carcinoma cells through p38 mitogen-activated protein kinase-mediated mitochondrial and autophagic apoptosis
- vitro+vivo, RCC, 786-O
Synergy↑, Casp↑, LC3II↑, TumAuto↑, Apoptosis↑, MAPK↑, TumCG↓, MMP?, Bax:Bcl2↑,
8683- MLT,    Intra-tumor ROS amplification by melatonin interferes in the apoptosis-autophagy-inflammation-EMT collusion in the breast tumor microenvironment
- in-vivo, BC, NA
ROS↑, SIRT1↑, IL6↓, STAT3↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, tumCV↓, JNK↑, P53↑, Bax:Bcl2↑, cl‑Casp3↑, Apoptosis↑, eff∅, TumAuto↑, EMT↓, Half-Life↓, CompStab↓, BioAv↓, Dose↝, TumW↓, TumVol↓, Ki-67↓, PTEN↑,
8905- MOR,    Molecular chemoprevention by morin – A plant flavonoid that targets nuclear factor kappa B in experimental colon cancer
- in-vivo, CRC, NA
NF-kB↓, TNF-α↓, IL6↓, COX2/PTGS2↓, PGE2↓, Bax:Bcl2↑, Dose↝,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, Var, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2/PTGS2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
1128- Myr,    Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer
- vitro+vivo, Ovarian, NA
MAPK↓, ERK↓, PI3K↓, Akt↓, p‑PARP↑, cl‑Casp3↑, Bax:Bcl2↑, TumCMig↓, SMAD3↓,
4225- NarG,    Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury
- in-vivo, AD, NA
*motorD↑, *BDNF↑, *VEGF↑, *Bax:Bcl2↓, *Casp3↓, *Apoptosis↓, *eff↑,
6490- Nimb,    Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer
- in-vitro, Oral, SCC4
PI3K↓, Akt↓, GSK‐3β↑, MMP↓, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, TumAuto↑, Beclin-1/ATG6↓, p62↑, PI3K↓, chemoPv↑,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, ChemoSen↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2/PTGS2↓, eff↑, Bax:Bcl2↑,
9017- Phyco,    Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
eff↑, TumCP↓, Tumccf↓, TumCCA↑, cycE/CCNE↓, CDK2↓, P21↑, Apoptosis↑, γH2AX↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, TumCMig↓, TumCA↑, angioG↓, COX2/PTGS2↓, PGE2↓, MAPK↓, toxicity↓,
9011- Phyco,    Phycocyanin: A Potential Drug for Cancer Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Imm↑, *RenoP↑, *hepatoP↑, Synergy↑, EMT↓, TumCCA↑, P21↑, cycE/CCNE↓, CDK2↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, Bax:Bcl2↑, MMP↓, ROS↑, CD59↑, Fas?, IL1β↓, IL2↓, IFN-γ↓, TNF-α↓, JAK3↓, STAT3↓, IL4↑, COX2/PTGS2↓, PGE2↓, MMP9↓, MMP2↓, MMP9↓, TIMP2↓, Vim↓, COL1↓, E-cadherin↑, MDR1↓, AP-1↓, ChemoSen↑, chemoP↑, RadioS↑, TumAuto↑,
5162- PLB,    Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells
- vitro+vivo, Melanoma, A172
TumCG↓, TumCCA↑, Apoptosis↑, P21↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDC2↓, CDC25↑, Bax:Bcl2↑, Casp9↑, ROS↑, JNK↑, ERK↑, eff↓,
3371- QC,    Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a/β-Catenin and Akt/NF-κB signaling pathways
- in-vitro, GBM, T98G
TIMP2↑, TumCG↓, TumCMig↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, Bax:Bcl2↑, cl‑Casp9↑, cl‑Casp3↑, DNAdam↑, γH2AX↑, MGMT↓, cl‑PARP↑,
98- QC,    Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
- in-vivo, Stroke, NA
*Bcl-2↑, *BAX↓, *Bax:Bcl2↓, *cardioP↑, *Akt↑, *PI3K↑, *LDH↓,
82- QC,  ATG,    Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells
- in-vitro, Pca, LNCaP
AR↓, PI3K/Akt↓, miR-21↓, STAT3↓, BAD↓, PRAS40↓, GSK‐3β↓, PSA↓, NKX3.1↑, Bax:Bcl2↑, miR-19b↓, miR-148a↓, AMPKα↓, TumCP↓, chemoPv↑, TumCMig↓,
81- QC,  EGCG,    Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
- in-vivo, Pca, NA
COMT↓, MRP1/ABCC1↓, Ki-67↓, Bax:Bcl2↑, AR↓, Akt↓, p‑ERK↓, COMT↓, Synergy↑, chemoPv↑, BioAv↑,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp/ABCB1↓, Synergy↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,

Showing Research Papers: 101 to 150 of 169
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 169

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 3,   Catalase↓, 1,   Catalase↑, 1,   Fenton↑, 2,   GPx1↓, 1,   GSH↓, 9,   mt-GSH↓, 1,   GSH/GSSG↓, 1,   GSSG↑, 1,   HO-1↓, 3,   HO-1↑, 2,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 1,   lipid-P↑, 2,   MDA↑, 3,   NRF2↓, 4,   NRF2↑, 4,   NRF2⇅, 1,   p‑NRF2↑, 1,   OSI↑, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 11,   ROS↑, 68,   ROS⇅, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SOD↓, 5,   SOD↑, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC↓, 1,   TBARS↑, 1,   TOS↑, 1,   Trx2↓, 1,   TrxR↓, 1,   TrxR1↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

STEAP3↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 3,   CDC25↑, 1,   HSP60/HSPD1↓, 1,   mitResp↓, 1,   mtDam↑, 8,   OCR↓, 1,   mt-OXPHOS↓, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ALAT↓, 1,   AMPK↑, 6,   ATP↓, 5,   CAIX/CA9↓, 1,   CholSyn↓, 1,   ECAR↝, 1,   FASN↓, 2,   GlucoseCon↓, 4,   Glycolysis↓, 8,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 5,   HK2↓, 4,   lactateProd↓, 1,   LDHA↓, 2,   NADPH↓, 1,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PKM2↓, 2,   PKM2↑, 1,   PPP↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   TS↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 3,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 93,   mt-Apoptosis↑, 4,   BAD↓, 2,   BAD↑, 1,   BAX↑, 21,   Bax:Bcl2↓, 2,   Bax:Bcl2↑, 149,   Bcl-2↓, 25,   Bcl-xL↓, 8,   Casp↑, 12,   Casp12?, 1,   Casp12↑, 3,   Casp3?, 1,   Casp3↓, 2,   Casp3↑, 67,   cl‑Casp3↑, 16,   proCasp3↓, 1,   Casp6↑, 1,   Casp7↑, 5,   cl‑Casp7↑, 2,   Casp8↑, 12,   Casp8∅, 2,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 45,   cl‑Casp9↑, 9,   proCasp9↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 47,   Diablo↑, 2,   DR5↑, 4,   FADD↑, 1,   Fap1↓, 1,   Fas?, 1,   Fas↓, 1,   Fas↑, 5,   FasL↑, 2,   Ferroptosis↑, 1,   IAP1↓, 4,   IAP2/BIRC3↓, 3,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 3,   Mcl-1?, 1,   Mcl-1↓, 1,   MDM2↓, 4,   MDM2↑, 1,   MLKL↑, 1,   Necroptosis↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 5,   p‑p38↑, 2,   PUMA↑, 2,   Pyro↑, 1,   p‑RIP3↑, 1,   survivin↓, 16,   TRAIL↑, 2,   TumCD↑, 3,   XIAP↓, 8,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 36,   Akt↑, 2,   p‑Akt↓, 17,   AMPKα↓, 1,   CIP2A↓, 1,   CK2↓, 4,   p‑cMET↑, 1,   CREB2↓, 1,   EGFR↓, 12,   ERK↓, 11,   ERK↑, 6,   p‑ERK↓, 6,   p‑ERK↑, 1,   p‑ERK⇅, 1,   e-ERK↑, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 5,   IKKα↓, 1,   IκB↓, 1,   JAK↓, 1,   JAK2↓, 2,   JAK3↓, 1,   JNK↑, 4,   p‑JNK↓, 3,   LIMK1↓, 1,   MAPK↓, 5,   MAPK↑, 4,   MEK↓, 4,   MKK4↓, 1,   mTOR↓, 11,   p‑mTOR↓, 6,   p70S6↓, 1,   P70S6K↓, 1,   PI3K↓, 23,   p‑PI3K↓, 2,   PI3K/Akt↓, 3,   PKCδ↓, 2,   PP2A↑, 1,   PRAS40↓, 1,   PRAS40↑, 1,   PTEN↑, 5,   p‑PTEN↓, 1,   Raf↓, 2,   RAS↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 1,   Src↓, 1,   STAT3↓, 17,   p‑STAT3↓, 4,   p‑STAT3↑, 1,   STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   ChrMod↝, 1,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 15,   DNMTs↓, 1,   FOXM1↓, 1,   FOXO3↓, 1,   FOXO3↑, 3,   FOXO4↑, 2,   HATs↓, 2,   HDAC↓, 7,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   HES1↓, 1,   miR-148a↓, 1,   miR-19b↓, 1,   miR-200c↑, 1,   miR-21↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   Myc↓, 1,   n-MYC↓, 2,   NDRG1↑, 1,   OCT4↓, 2,   other↑, 1,   other↝, 3,   PCAF↓, 1,   SOX2↓, 3,   SOX4↓, 1,   tumCV?, 1,   tumCV↓, 25,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↓, 1,   ER Stress↑, 8,   ERStress↑, 1,   HSP90↓, 2,   HSPs↓, 1,   HTRA↓, 1,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 5,   ATG7↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 8,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 7,   LC3s↑, 1,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 3,   p62↑, 5,   PARK2↑, 1,   RUBCN↓, 1,   TumAuto↑, 15,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNA-PK↑, 1,   DNAdam↓, 2,   DNAdam↑, 22,   mt-DNAdam↑, 1,   hTERT/TERT↓, 4,   MGMT↓, 1,   NKX3.1↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 29,   P53∅, 1,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 3,   p‑PARP↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 37,   cl‑PARP1↑, 2,   PCNA↓, 6,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 8,   TOP2↓, 1,   TP53↑, 1,   γH2AX↑, 4,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK2↓, 11,   CDK4↓, 14,   CDK4↑, 1,   CDK6↓, 5,   CDK6↑, 1,   CDK8↓, 1,   Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 5,   cycD1/CCND1↓, 30,   CycD3↓, 1,   cycE/CCNE↓, 8,   Ki-67↓, 10,   mitA↑, 1,   p19↑, 1,   P21↓, 1,   P21↑, 35,   p27/CDKN1B↑, 15,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA?, 2,   TumCCA↓, 2,   TumCCA↑, 67,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   BMP2↓, 1,   CD133↓, 3,   cFos↓, 2,   cMYB↓, 1,   CSCs↓, 13,   Diff↓, 1,   Diff↑, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 1,   HH↓, 3,   HMGCR↓, 1,   IGF-1↓, 3,   IGFBP3↑, 1,   p‑Jun↓, 1,   Ki-67↓, 10,   p‑mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 2,   NOTCH↓, 4,   NOTCH1↓, 1,   NOTCH1↑, 1,   NOTCH2↓, 1,   p300↓, 1,   SCF↓, 1,   Shh↓, 2,   TumCG?, 1,   TumCG↓, 32,   TumCP↓, 41,   TumCP↑, 1,   TumCP∅, 1,   Wnt↓, 3,   Wnt↑, 1,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   APC↑, 1,   Ca+2↑, 10,   Ca+2↝, 1,   i-Ca+2?, 1,   cal2↑, 2,   Cav1↓, 1,   COL1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 8,   EMT↓, 17,   EMT↝, 1,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 2,   p‑FAK↑, 1,   Fibronectin↓, 1,   ITGB4↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP16↓, 1,   MMP2↓, 21,   MMP3↓, 3,   MMP7↓, 2,   MMP9↓, 24,   MMPs↓, 5,   MUC4↓, 1,   N-cadherin↓, 3,   NCAM↓, 1,   SMAD3↓, 2,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 3,   TIMP1↑, 1,   TIMP2↓, 2,   TIMP2↑, 2,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCA↑, 1,   TumCI↓, 14,   TumCMig↓, 19,   TumCMig↑, 1,   TumMeta↓, 11,   Twist↓, 2,   uPA↓, 2,   Vim↓, 3,   β-catenin/ZEB1↓, 13,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 22,   angioG↑, 1,   Endoglin↑, 1,   HIF-1↓, 2,   Hif1a↓, 13,   NO↓, 1,   NO↑, 1,   VEGF↓, 26,   VEGF↑, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1,   CellMemb↑, 1,   CLDN1↑, 1,   EPR↑, 1,   GLUT1↓, 5,   GLUT4↓, 2,   IBI↑, 1,   MMP?, 1,   MMP↓, 55,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,   OCLN↑, 1,   TJ↑, 1,   TRPV1↑, 1,   TRPV1↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD44↓, 6,   CD59↑, 1,   cDC2↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 21,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   DR4↑, 2,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL10↑, 1,   IL1β↓, 5,   IL2↓, 1,   IL2↑, 2,   IL4↑, 1,   IL6↓, 7,   IL8↓, 2,   IL8↑, 1,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 7,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   NF-kB↓, 42,   NF-kB↑, 1,   p‑NF-kB↓, 1,   NK cell↑, 1,   p65↓, 1,   p‑p65↓, 1,   PD-L1↓, 3,   PGE2↓, 7,   PSA↓, 2,   TNF-α↓, 9,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,   COMT↓, 2,   ER-α36↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   ERβ/ESR2↑, 1,   PPARα↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 6,   BioAv↑, 9,   BioAv↝, 2,   BioEnh↑, 3,   CBR1↓, 1,   chemoR↓, 1,   ChemoSen↑, 34,   CompStab↓, 1,   CompStab↑, 1,   CYP1A1↑, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 1,   Dose↝, 8,   Dose∅, 5,   eff↓, 23,   eff↑, 24,   eff↝, 6,   eff∅, 2,   Half-Life↓, 3,   Half-Life↝, 1,   MDR1↓, 4,   MDR1↑, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   RadioS↑, 13,   selectivity↑, 29,   Synergy↑, 31,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 2,   AR↓, 5,   AST↓, 1,   EGFR↓, 12,   ERα/ESR1↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 5,   hTERT/TERT↓, 4,   IL6↓, 7,   LDH↓, 3,   LDH↑, 1,   LDH↝, 1,   Myc↓, 1,   PD-L1↓, 3,   PSA↓, 2,   TP53↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 13,   antiNeop↑, 3,   AntiTum↑, 4,   cardioP↑, 1,   chemoP↑, 5,   chemoPv↑, 9,   ChemoSideEff↓, 4,   hepatoP↑, 4,   memory↑, 1,   OS↑, 2,   Pain↓, 1,   radioP↑, 1,   Risk↓, 1,   toxicity↓, 2,   toxicity↝, 2,   TumVol↓, 6,   TumVol↑, 1,   TumW↓, 5,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 536

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 17,   i-antiOx↑, 1,   Catalase↑, 5,   GCLC↝, 1,   GCLM↝, 1,   GPx↑, 3,   GPx4↑, 1,   GSH↑, 6,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 3,   H2O2↑, 1,   HO-1↑, 10,   Iron↓, 1,   i-Iron↓, 1,   Keap1↝, 1,   lipid-P↓, 5,   MDA↓, 11,   NOX↓, 1,   NQO1↑, 1,   NQO1↝, 1,   NRF2↑, 11,   p‑NRF2↑, 1,   ROS↓, 23,   ROS↑, 2,   SOD↑, 11,   TAC↑, 1,   Trx1↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 1,   ATP↑, 2,   glucose↓, 1,   GSK‐3β↓, 3,   p‑GSK‐3β↑, 1,   LDL↓, 2,   lipidLev↓, 1,   NADPH↓, 1,   PLA2↓, 1,   SCFAs↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 6,   mt-Apoptosis↓, 1,   ASK1↓, 1,   BAX↓, 1,   Bax:Bcl2↓, 14,   Bax:Bcl2↑, 3,   Bax:Bcl2↝, 1,   Bcl-2↑, 3,   Casp↓, 1,   Casp3↓, 4,   Casp3↑, 2,   Casp3∅, 1,   cl‑Casp3↓, 5,   cl‑Casp3↑, 1,   proCasp3↓, 1,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↓, 2,   Casp9↑, 2,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c∅, 1,   Fas↑, 2,   Ferroptosis↓, 1,   p‑p38↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 4,   Akt2↓, 1,   CREB↑, 1,   ERK↓, 2,   IKKα↓, 1,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 2,   mTOR↑, 1,   PI3K↑, 4,   PKCδ↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 1,   P53↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycE/CCNE↑, 1,   P21↓, 1,   P21↑, 2,   TumCCA↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 1,   LAMs↑, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MUC1↑, 1,   Smad1↑, 1,   TGF-β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   NO↓, 1,   VCAM-1↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   IBI↑, 1,   MMP↓, 2,   MMP↑, 3,   MMP∅, 1,   OCLN↝, 1,   TJ↑, 1,   TRPC1↓, 1,   ZO-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 4,   IL33↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 7,   IL8↓, 2,   Imm↑, 1,   Imm⇅, 1,   Inflam↓, 17,   MIP‑1α/CCL3↓, 1,   MIP2↓, 1,   NeuroI↓, 1,   NF-kB↓, 9,   NK cell↑, 1,   NLRP3↓, 2,   p65↓, 1,   PGE2↓, 1,   RAGE↓, 1,   TLR4↓, 1,   TNF-α↓, 9,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BDNF↑, 6,   GABA↑, 1,   PSD95↑, 3,   SYP↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 6,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↝, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 5,   BioAv↝, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↑, 3,   Half-Life↓, 1,   Half-Life∅, 1,   selectivity↑, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   AST↓, 3,   BloodF↑, 1,   BMD↑, 1,   BP↓, 1,   BP↝, 1,   CRP↓, 2,   hs-CRP↓, 1,   IL6↓, 7,   LDH↓, 3,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 3,   AntiArt↑, 3,   AntiCan↑, 2,   AntiDiabetic↑, 7,   antiPs↑, 1,   cardioP↑, 9,   CardioT↓, 1,   chemoP↑, 3,   chemoPv↑, 1,   cognitive↑, 6,   hepatoP↑, 9,   Learn↑, 1,   memory↑, 5,   motorD↑, 1,   Mucositis↓, 1,   neuroP↑, 15,   Obesity↓, 1,   radioP↑, 3,   RenoP↑, 7,   Stroke↓, 1,   toxicity↓, 9,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   AntiViral↑, 3,   Bacteria↓, 2,   GutMicro↑, 3,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 4,  
Total Targets: 215

Scientific Paper Hit Count for: Bax:Bcl2, Bax:Bcl2 ratio
9 Thymoquinone
7 Apigenin (mainly Parsley)
6 Baicalein
6 Berberine
6 Emodin
6 Lycopene
6 Sulforaphane (mainly Broccoli)
5 Quercetin
4 Isoliquiritigenin
4 Luteolin
3 Cisplatin
3 EGCG (Epigallocatechin Gallate)
3 Curcumin
3 Caffeic acid
3 Carvacrol
3 Crocetin
3 Ellagic acid
3 Formononetin
3 Garcinol
3 iodine
3 isoorientin
3 Ivermectin
3 Melatonin
2 Silver-NanoParticles
2 Arctigenin
2 Docetaxel
2 Berbamine
2 Beta-Caryophyllene
2 Propolis -bee glue
2 Chlorogenic acid
2 Coenzyme Q10
2 D-limonene
2 Dandelion Root
2 Gambogic Acid
2 Graviola
2 HydroxyTyrosol
2 Licochalcone A
2 Magnolol
2 Myricetin
2 Phycocyanin
1 2-DeoxyGlucose
1 Astragalus
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Andrographis
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Paclitaxel/Taxol
1 Betulinic acid
1 borneol
1 Boswellia (frankincense)
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Centella asiatica / Gotu kola → asiaticoside
1 Chrysin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Copper and Cu NanoParticles
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 Diclofenac
1 Radiotherapy/Radiation
1 Ginkgo biloba-EGb 761
1 Ferulic acid
1 Fenbendazole
1 Fisetin
1 Flaxseed/Linseed
1 Fucoidan
1 Gallic acid
1 Ginkgolic acids
1 Ginkgo biloba
1 Ginkgetin
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Huperzine A/Huperzia serrata
1 Hyperoside
1 Indole-3-carbinol
1 isoquercitrin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Juglone
1 Kaempferol
1 Matrine
1 Magnetic Fields
1 Morin
1 Naringin
1 Nimbolide
1 Plumbagin
1 Rosmarinic acid
1 salinomycin
1 Terpinen-4-ol / Tea Tree Oil
1 doxorubicin
1 Thymol-Thymus vulgaris
1 Vitamin D3
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:352  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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