N-cadherin Cancer Research Results

N-cadherin, N-cadherin: Click to Expand ⟱
Source:
Type:
Also known as Cadherin2 (CDH2).
N-cadherin is a type of cell adhesion molecule that plays a crucial role in the development and maintenance of tissue structure. In the context of cancer, N-cadherin has been implicated in the progression and metastasis of various types of tumors.
N-cadherin expression is increased in various types of cancer.
Normally, N-cadherin is expressed in mesenchymal cells, such as fibroblasts and smooth muscle cells. However, in cancer cells, N-cadherin expression is often upregulated, which can contribute to the epithelial-to-mesenchymal transition (EMT). EMT is a process by which epithelial cells acquire a more mesenchymal phenotype, which is characterized by increased motility, invasiveness, and resistance to apoptosis.
The expression of N-cadherin in cancer cells is closely associated with tumorigenesis and metastasis. Additionally, the soluble N-cadherin level in the serum of cancer patients is much higher than that in the serum of healthy patients, revealing a positive relation with poor prognosis.
Scientific Papers found: Click to Expand⟱
1820- VitK3,    Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,

Showing Research Papers: 101 to 101 of 101
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 101

Pathway results for Effect on Cancer / Diseased Cells:


Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   p300↓, 1,   TOPflash↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   Vim↓, 1,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: N-cadherin, N-cadherin
8 Curcumin
6 Resveratrol
5 Berberine
5 Luteolin
5 Quercetin
4 Fisetin
4 Honokiol
4 Thymoquinone
3 Artemisinin
3 Baicalein
3 Urolithin
2 Astragalus
2 Ashwagandha(Withaferin A)
2 Betulinic acid
2 Chlorogenic acid
2 Grapeseed extract
2 Juglone
2 Piperlongumine
2 Rosmarinic acid
2 Sulforaphane (mainly Broccoli)
2 Silymarin (Milk Thistle) silibinin
2 Ursolic acid
1 Allicin (mainly Garlic)
1 Cisplatin
1 Apigenin (mainly Parsley)
1 Astaxanthin
1 Baicalin
1 Biochanin A
1 Butyrate
1 Capsaicin
1 Carvacrol
1 Cannabidiol
1 Chrysin
1 Crocetin
1 Oxaliplatin
1 Cyclopamine
1 Emodin
1 Eurycomanone
1 Eugenol
1 Ginger/6-Shogaol/Gingerol
1 Proanthocyanidins
1 HydroxyTyrosol
1 Laetrile B17 Amygdalin
1 Lycopene
1 Magnolol
1 Oroxylin A
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Piperine
1 Rutin
1 salinomycin
1 Shikonin
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:355  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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